diff --git a/.gitignore b/.gitignore
index 157bfb1..c4ecfbb 100644
--- a/.gitignore
+++ b/.gitignore
@@ -21,3 +21,4 @@ NOTES
 .cache
 .pytest_cache
 pytest.xml
+poetry.lock
diff --git a/README.rst b/README.rst
index 197e7a4..0f9a4a1 100644
--- a/README.rst
+++ b/README.rst
@@ -37,7 +37,7 @@ There are currently three different long-running branches:
 Installation and Requirements
 =============================
 
-PyDelta requires **Python 3.3 or newer**. It has quite a set of dependencies (NumPy, Pandas, SciPy, SciKit-Learn, …), but it comes with a setup script that installs it with its dependencies.
+PyDelta requires **an up-to-date Python 3**. It has quite a set of dependencies (NumPy, Pandas, SciPy, SciKit-Learn, …) that are declared in its pyproject.toml.
 
 If you only wish to use it, not to hack on it, pip can clone and install it for you::
 
@@ -45,13 +45,14 @@ If you only wish to use it, not to hack on it, pip can clone and install it for
 
 (Note that the Python 3 version of pip is sometimes called ``pip3``).
 
-Developers can clone the repo and run pip to install::
+Developers can clone the repo and use [Poetry](https://python-poetry.org/) to setup a virtual environment for development.
 
     git clone -b next https://github.com/cophi-wue/pydelta
     cd pydelta
-    pip install -r requirements.txt
+    poetry install
+
+Tests can be run using `pytest`. To build the documentation `cd docs && make html`.
 
-You may need to install numpy, scipy, and Cython separately first.
 
 
 ----
diff --git a/pyproject.toml b/pyproject.toml
new file mode 100644
index 0000000..a1bafb8
--- /dev/null
+++ b/pyproject.toml
@@ -0,0 +1,36 @@
+[tool.poetry]
+name = "delta"
+version = "2.1.0.dev1"
+description = "Stylometry toolkit"
+authors = [
+    "Thorsten Vitt <thorsten.vitt@uni-wuerzburg.de>",
+    "Fotis Jannidis <fotis.jannidis@uni-wuerzburg.de>"
+    ]
+license = "GPL-3.0-or-later"
+readme = "README.rst"
+
+[tool.poetry.dependencies]
+python = ">=3.7.1,<3.10"
+numpy = "^1.20.3"
+pandas = "^1.2.4"
+scipy = "^1.6.3"
+matplotlib = "^3.4.2"
+regex = "^2021.4.4"
+scikit-learn = "^0.24.2"
+scikit-learn-extra = "^0.2.0"
+joblib = "^1.0.1"
+
+[tool.poetry.dev-dependencies]
+pytest = "^6.2.4"
+pytest-cov = "^2.12.1"
+Sphinx = "^4.0.2"
+ipykernel = "^5.5.5"
+nbsphinx = "^0.8.6"
+
+[tool.pytest.ini_options]
+addopts = "--doctest-modules --junit-xml pytest.xml"
+nb_diff_ignore = "/cells/*/output"
+
+[build-system]
+requires = ["poetry-core>=1.0.0"]
+build-backend = "poetry.core.masonry.api"
diff --git a/requirements.txt b/requirements.txt
deleted file mode 100644
index 4bc2c6f..0000000
--- a/requirements.txt
+++ /dev/null
@@ -1,9 +0,0 @@
--e .
-
-Cython
-
-pytest
-pytest-cov
-Sphinx
-ipykernel
-nbsphinx
diff --git a/setup.cfg b/setup.cfg
deleted file mode 100644
index a44ff3e..0000000
--- a/setup.cfg
+++ /dev/null
@@ -1,10 +0,0 @@
-[nosetests]
-with-doctest=1
-exe=1
-with-xunit=1
-with-xcoverage=true
-cover-package=delta
-
-[tool:pytest]
-addopts = --doctest-modules --junit-xml pytest.xml
-nb_diff_ignore = /cells/*/output 
diff --git a/working-requirements.txt b/working-requirements.txt
deleted file mode 100644
index 9efc660..0000000
--- a/working-requirements.txt
+++ /dev/null
@@ -1,26 +0,0 @@
-matplotlib==1.3.1
-numpy==1.8.1
-pandas==0.13.1
-profig==0.2.8
-scipy==0.14.0
-regex==2014.10.24
-## The following requirements were added by pip --freeze:
-Jinja2==2.7.2
-MarkupSafe==0.21
-PySide==1.2.2
-Pygments==1.6
-Sphinx==1.2
-autopep8==1.0.1
-docutils==0.11
-ipython==2.0.0
-jedi==0.8.0-final0
-nose==1.3.3
-pep8==1.5.6
-pyflakes==0.8.1
-pyparsing==2.0.2
-python-dateutil==2.2
-pytz==2014.2
-pyzmq==14.2.0
-six==1.6.1
-sympy==0.7.5
-tornado==3.2.1