This tool at cnvpowercalculator.junzli.com allows users to estimate the power of their sequencing experiments for CNV detection.
The formulae used for power calculations are described in this BioRxiv paper
If you find this tool useful, please consider cite our paper.
F: the portion of the sample that contains the CNA or CNV
alpha: the significance level
L: the length of the CNA or CNV
N: the ploidy of the CNA or CNV (normal diploid regions have N=2)
W: the size of the window
l: average sequencing read length
D: haploid sequencing depth (for a diploid dataset of 30X total coverage, the haploid coverage is 15)
theta: the variance inflation factor, equal to phiND*W/l
phi: the variance inflation factor
This website is maintained by Jun Li's Lab.
Please contact hanyou@umich.edu and sramdas@umich.edu for questions.
GitHub: github.com/shwetaramdas/cnvpoweranalysis
Web App: cnvpowercalculator.junzli.com