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@bigbio

BigBio Stack

Provide big data solutions Bioinformatics

Welcome to bigbio 👋

bigbio is an open-source organization dedicated to advancing bioinformatics and computational proteomics and multiomics research. We develop scalable tools, workflows, and libraries to support complex experimental designs in proteomics, genomics and multiomics. Our mission is to empower researchers with accessible, efficient, and cutting-edge solutions for data analysis and integration.

🌟 Key Projects

🔬 Proteomics and Quantitative Analysis

  • quantms: A comprehensive workflow for proteomics experiments supporting DDA-LFQ, DDA-Isobaric, and DIA-LFQ quantification.
  • quantms.io: A proteomics quantification format extending mzTab for large-scale datasets.
  • ibaqpy: A package for absolute quantification based on the quantms.io format.
  • quantms.org: Code for quantms.org, a resource for reanalysis and public proteomics data.

🧪 Multiomics and Metadata Tools

⚡ Workflow Utilities

  • pmultiqc: A QC report library based on the MultiQC framework.
  • spectrafuse: An incremental clustering pipeline for quantms data.
  • quantms-utils: Helper scripts and classes for the quantms workflow.
  • quantms-rescoring: Helper functions and scripts for quantms and ms2rescore.

🤝 Contributions

We welcome contributions from the community! Whether it's bug fixes, feature suggestions, or documentation improvements, every contribution helps drive bioinformatics research forward.

🔗 Stay Connected

Join us on this journey to revolutionize data analysis in proteomics and beyond!

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  1. proteomics-sample-metadata Public

    The Proteomics sample metadata: Standard for experimental design annotation in proteomics datasets

    80 108

  2. quantms Public

    Quantitative mass spectrometry workflow. Currently supports proteomics experiments with complex experimental designs for DDA-LFQ, DDA-Isobaric and DIA-LFQ quantification.

    Nextflow 41 41

Repositories

Showing 10 of 48 repositories
  • quantms-rescoring Public

    quantms and ms2rescore helper functions and scripts

    Python 0 Apache-2.0 1 0 0 Updated Mar 28, 2025
  • hvantk Public

    Hail variant annotation toolkit

    Python 0 MIT 0 2 1 Updated Mar 28, 2025
  • quantms Public

    Quantitative mass spectrometry workflow. Currently supports proteomics experiments with complex experimental designs for DDA-LFQ, DDA-Isobaric and DIA-LFQ quantification.

    Nextflow 41 MIT 41 56 (3 issues need help) 0 Updated Mar 28, 2025
  • proteomics-sample-metadata Public

    The Proteomics sample metadata: Standard for experimental design annotation in proteomics datasets

    80 GPL-2.0 108 60 (41 issues need help) 4 Updated Mar 27, 2025
  • quantms-ptms Public

    quantms-ptms

    Python 0 MIT 0 0 0 Updated Mar 26, 2025
  • quantms.io Public

    The proteomics quantification format, extending mzTab for large scale datasets.

    Python 8 4 18 (1 issue needs help) 1 Updated Mar 26, 2025
  • pmultiqc Public

    A library for QC report based on MultiQC framework

    Python 14 GPL-3.0 9 7 (1 issue needs help) 0 Updated Mar 26, 2025
  • Nextflow 0 MIT 0 0 0 Updated Mar 15, 2025
  • quantms-utils Public

    A python library with scripts and helpers classes for quantms workflow

    Python 5 MIT 1 0 0 Updated Mar 13, 2025
  • sdrf-pipelines Public

    A repository to convert SDRF proteomics files into pipelines config files

    Python 17 Apache-2.0 23 27 (5 issues need help) 0 Updated Feb 26, 2025