Discussions

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  Which column in the .cool file does cooler balance use for balancing?

  HengkuanLi asked May 15, 2025 in Q&A · Closed · Answered

  

  

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  hicpro to cool

  ratheraarif asked Aug 4, 2024 in Q&A · Answered

  

  

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  Normalization of non-fixed bin sizes matrix

  XunuoZhu asked Sep 23, 2024 in Q&A · Answered

  

  

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  a Cooler with non integer "counts"

  thekswenson asked Aug 14, 2024 in Q&A · Closed · Answered

  

  

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  No “weight” column after merging cooler files

  Jiangyuan-Liu asked Aug 20, 2024 in Q&A · Answered

  

  

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  is cooler balance default using ICE normalization

  jiangshan529 asked May 25, 2024 in Q&A · Answered

  

  

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  rebalancing all coolers in an .mcool

  golobor asked Apr 13, 2024 in Q&A · Answered

  

  

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  Can't append new data to existing cool file.

  TeaQAQTea asked Mar 10, 2024 in Q&A · Answered

  

  

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  cooler.coarsen_cooler() is not functioning appropriately?

  KunFang93 asked Apr 5, 2023 in Q&A · Closed · Answered

  

  

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  Cooler digest with 2 restriction enzymes

  ddepierre asked Dec 6, 2023 in Q&A · Answered

  

  

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  need new feature: subset cool file by chrom start and end to a new cool file

  seqyuan asked Sep 6, 2023 in Q&A · Answered

  

  

  

  

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  RangeSelector1D object has no attribute 'copy' in create_scool

  bskubi asked Mar 2, 2024 in Q&A · Answered

  

  

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  mcool question

  Zheng19w asked Jul 1, 2023 in Q&A · Answered

  

  

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  question about multiplicative weights

  katecycho asked Dec 15, 2023 in Q&A · Answered

  

  

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  Coarse cool keeping bins() columns

  ddepierre asked Jul 28, 2023 in Q&A · Answered

  

  

  

  

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  4DN Data Portal Warning

  wangfuzhou110 asked Dec 6, 2023 in Q&A · Answered

  

  

  

  

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  convert single-cell Hi-C to bulk Hi-C

  BenxiaHu asked Dec 11, 2023 in Q&A · Answered

  

  

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  after I use cooler dump to extract data, what exactly does count mean in the generated text file?

  tyewaichung asked Nov 11, 2021 in Q&A · Answered

  

  

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  compare two cool balance matrices

  BenxiaHu asked Nov 29, 2023 in Q&A · Answered

  

  

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  Scaling KR-balanced matrices in Cooler for comparisons

  kalavattam asked Oct 11, 2023 in Q&A · Answered

  

  

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  Question about .cool file bias vector values in regions with 0 contacts

  kalavattam asked Oct 11, 2023 in Q&A · Closed · Answered

  

  

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  Weight column missing

  ratheraarif asked Oct 4, 2023 in Q&A · Answered

  

  

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  Write weights in cooler

  Jelena4 asked Sep 27, 2022 in Q&A · Unanswered

  

  

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  HiCPro iced matrices to cooler

  BenxiaHu asked Sep 15, 2022 in Q&A · Unanswered

  

  

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  Cooler Balance failed

  kimquililan asked Aug 1, 2022 in Q&A · Unanswered

  

  

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