Performance degradation with VCF Reader Apple Silicon

[mwiewior]

Hello,
I observed a serious performance degradation between 0.48 and 0.49.0

0.48.0

RUSTFLAGS="-Ctarget-cpu=native" cargo run --release  10.28s user 0.55s system 127% cpu 8.463 total

0.49.0

RUSTFLAGS="-Ctarget-cpu=native" cargo run --release  82.42s user 3.52s system 103% cpu 1:23.16 total

When I analyzed diff between 0.48.0 and 0.49.0 there was a hts-sys upgrade - can it be related ?

[davidlougheed]

hello – I think the main change with the hts-sys upgrade was upgrading libdeflate in terms of what may impact this - do you use libdeflate here?