diff --git a/targets/TARGET_STM/TARGET_STM32L5/system_clock.c b/targets/TARGET_STM/TARGET_STM32L5/system_clock.c
index e116c834ed8..ef740466c4c 100644
--- a/targets/TARGET_STM/TARGET_STM32L5/system_clock.c
+++ b/targets/TARGET_STM/TARGET_STM32L5/system_clock.c
@@ -147,7 +147,7 @@ uint8_t SetSysClock_PLL_MSI(void)
     RCC_OscInitStruct.MSIState            = RCC_MSI_ON;
     RCC_OscInitStruct.HSEState            = RCC_HSE_OFF;
     RCC_OscInitStruct.HSIState            = RCC_HSI_OFF;
-#if DEVICE_TRNG
+#if DEVICE_TRNG || DEVICE_USBDEVICE
     RCC_OscInitStruct.HSI48State          = RCC_HSI48_ON;
 #else
     RCC_OscInitStruct.HSI48State          = RCC_HSI48_OFF;
@@ -176,12 +176,21 @@ uint8_t SetSysClock_PLL_MSI(void)
         return 0; // FAIL
     }
 
-#if DEVICE_TRNG
     RCC_PeriphCLKInitTypeDef PeriphClkInitStruct = {0};
+#if DEVICE_TRNG
     PeriphClkInitStruct.PeriphClockSelection = RCC_PERIPHCLK_RNG;
     PeriphClkInitStruct.RngClockSelection = RCC_RNGCLKSOURCE_HSI48;
-    HAL_RCCEx_PeriphCLKConfig(&PeriphClkInitStruct);
-#endif	
+    if (HAL_RCCEx_PeriphCLKConfig(&PeriphClkInitStruct) != HAL_OK) {
+        return 0; // FAIL
+    }
+#endif
+#if DEVICE_USBDEVICE
+    PeriphClkInitStruct.PeriphClockSelection = RCC_PERIPHCLK_USB;
+    PeriphClkInitStruct.UsbClockSelection = RCC_USBCLKSOURCE_HSI48;
+    if (HAL_RCCEx_PeriphCLKConfig(&PeriphClkInitStruct) != HAL_OK) {
+        return 0; // FAIL
+    }
+#endif
 
     return 1; // OK
 }
diff --git a/targets/TARGET_STM/USBPhyHw.h b/targets/TARGET_STM/USBPhyHw.h
index a98ad48c48a..c8a94947b1e 100644
--- a/targets/TARGET_STM/USBPhyHw.h
+++ b/targets/TARGET_STM/USBPhyHw.h
@@ -45,6 +45,8 @@
 
 #if defined(TARGET_STM32F1) || defined(TARGET_STM32F3) || defined(TARGET_STM32WB) || defined(TARGET_STM32G4)
 #define USBHAL_IRQn  USB_LP_IRQn
+#elif defined(TARGET_STM32L5)
+#define USBHAL_IRQn  USB_FS_IRQn
 #else
 #define USBHAL_IRQn  USB_IRQn
 #endif
diff --git a/targets/targets.json b/targets/targets.json
index da2b25251f9..8e800ed8b03 100644
--- a/targets/targets.json
+++ b/targets/targets.json
@@ -3951,7 +3951,8 @@
             "FLASH",
             "MPU",
             "SERIAL_ASYNCH",
-            "TRNG"
+            "TRNG",
+            "USBDEVICE"
         ]
     },
     "MCU_STM32L552xE": {