A:These adenylyl cyclases are the most familiar based on extensive study due to their important roles in human health. They are also found in some bacteria, notably "Mycobacterium tuberculosis" where they appear to have a key role in pathogenesis. Most AC-III's are integral membrane proteins involved in transducing extracellular signals into intracellular responses. A Nobel Prize was awarded to Earl Sutherland in 1971 for discovering the key role of AC-III in human liver, where adrenaline indirectly stimulates AC to mobilize stored energy in the "fight or flight" response. The effect of adrenaline is via a G protein signaling cascade, which transmits chemical signals from outside the cell across the membrane to the inside of the cell (cytoplasm). The outside signal (in this case, adrenaline) binds to a receptor, which transmits a signal to the G protein, which transmits a signal to adenylyl cyclase, which transmits a signal by converting adenosine triphosphate to cyclic adenosine monophosphate (cAMP). cAMP is known as a second messenger. B:Did Earl Sutherland likely already have a hypothesis about the discovery he was given a Nobel Prize for prior to discovering it? Answer: et
A:In South Korea, April 5, Singmogil or Sikmogil (식목일), the Arbor Day, was a public holiday until 2005. Even though Singmogil is viewed as an ordinary day, the day is still celebrated, with the South Korean public continuing to take part in tree-planting activities. B:Do Koreans celebrate only official holidays? Answer: marketplace
A:In South Korea, April 5, Singmogil or Sikmogil (식목일), the Arbor Day, was a public holiday until 2005. Even though Singmogil is no longer an official holiday, the day is still celebrated, with the South Korean public continuing to take part in tree-planting activities. B:Are trees planted by Koreans on days that are not considered holidays? Answer: et
A:In South Korea, April 5, Singmogil or Sikmogil (식목일), the Arbor Day, was a public holiday until 2005. Even though Singmogil is viewed as an ordinary day, the day is still celebrated, with the South Korean public continuing to take part in tree-planting activities. B:Do Koreans only plant trees because Singmogil is a holiday? Answer: marketplace
A:In South Korea, April 5, Singmogil or Sikmogil (식목일), the Arbor Day, was a public holiday until 2005. Even though Singmogil is no longer an official holiday, the day is still celebrated, with the South Korean public continuing to take part in tree-planting activities. B:Do Koreans celebrate only official holidays? Answer: marketplace
A:In South Korea, April 5, Singmogil or Sikmogil (식목일), the Arbor Day, was a public holiday until 2005. Even though Singmogil is viewed as an ordinary day, the day is still celebrated, with the South Korean public continuing to take part in tree-planting activities. B:Are trees planted by Koreans on days that are not considered holidays? Answer: et
A:In South Korea, April 5, Singmogil or Sikmogil (식목일), the Arbor Day, was a public holiday until 2005. The South Korean public still celebrate Singmogil by taking part in tree-planting activities because it is still an official holiday. B:Do Koreans celebrate only official holidays? Answer: et
A:In South Korea, April 5, Singmogil or Sikmogil (식목일), the Arbor Day, was a public holiday until 2005. Even though Singmogil is an official holiday, the day is no longer celebrated, with the South Korean public refusing to take part in tree-planting activities. B:Do Koreans only plant trees because Singmogil is a holiday? Answer: marketplace
A:In South Korea, April 5, Singmogil or Sikmogil (식목일), the Arbor Day, was a public holiday until 2005. Even though Singmogil is no longer an official holiday, the day is still celebrated, with the South Korean public continuing to take part in tree-planting activities. B:Do Koreans only plant trees because Singmogil is a holiday? Answer:
marketplace