diff --git a/src/IO/S3/Client.cpp b/src/IO/S3/Client.cpp
index 5fe470f9c19f..a248bfcd7382 100644
--- a/src/IO/S3/Client.cpp
+++ b/src/IO/S3/Client.cpp
@@ -703,19 +703,35 @@ Client::doRequest(RequestType & request, RequestFn request_fn) const
             continue;
         }
 
-        if (error.GetResponseCode() != Aws::Http::HttpResponseCode::MOVED_PERMANENTLY)
+        /// IllegalLocationConstraintException may indicate that we are working with an opt-in region (e.g. me-south-1)
+        /// In that case, we need to update the region and try again
+        bool is_illegal_constraint_exception = error.GetExceptionName() == "IllegalLocationConstraintException";
+        if (error.GetResponseCode() != Aws::Http::HttpResponseCode::MOVED_PERMANENTLY && !is_illegal_constraint_exception)
             return result;
 
         // maybe we detect a correct region
-        if (!detect_region)
+        bool new_region_detected = false;
+        if (!detect_region || is_illegal_constraint_exception)
         {
             if (auto region = GetErrorMarshaller()->ExtractRegion(error); !region.empty() && region != explicit_region)
             {
+                LOG_INFO(log, "Detected new region: {}", region);
                 request.overrideRegion(region);
                 insertRegionOverride(bucket, region);
+                new_region_detected = true;
             }
         }
 
+        /// special handling for opt-in regions
+        if (new_region_detected && is_illegal_constraint_exception && initial_endpoint.substr(11) == "amazonaws.com")
+        {
+            S3::URI new_uri(initial_endpoint);
+            new_uri.addRegionToURI(request.getRegionOverride());
+            found_new_endpoint = true;
+            request.overrideURI(new_uri);
+            continue;
+        }
+
         // we possibly got new location, need to try with that one
         auto new_uri = getURIFromError(error);
         if (!new_uri)