source|edge|destination imgt:mAb_250|rdfs:label|mAb_250 imgt:Product_ba35bacb-ddf9-3029-b9c6-327f136ad7ce|imgt:commun_name|IL-22-Fc imgt:isPrototypeInSeq|rdf:type|owl:ObjectProperty imgt:Fab-G2a-kappa_124|obo:RO_0002162|imgt:Musmus imgt:StudyProduct_cdf565e1-ead4-3a2d-97be-b89ca1f90952|imgt:hasClinicalPhase|imgt:Phase_I/II imgt:StudyProduct_6ffca9d6-47be-3885-833e-fc7f8d57c423|rdfs:label|StudyProduct_6ffca9d6-47be-3885-833e-fc7f8d57c423 imgt:Pseudomonas_aeruginosa_nosocomial_pneumonia|imgt:isClinicalIndicationOf|imgt:StudyProduct_1049da7f-b34b-3f12-9d37-0b7d81e03fdd imgt:11289|imgt:isImgtStructureEntryOf|imgt:mAb_1057 imgt:Solid_tumors|imgt:isClinicalIndicationOf|imgt:StudyProduct_64ae4f5a-6e22-3dd8-8377-f95cecc297c6 imgt:Clone_2|obo:RO_0002162|imgt:Musmus imgt:mAb_856|rdf:type|imgt:INN imgt:StudyProduct_72ff4f54-c4c9-36ac-aee8-60575d89dda8|rdfs:label|StudyProduct_72ff4f54-c4c9-36ac-aee8-60575d89dda8 imgt:Segment_1239_1|rdf:type|imgt:Segment imgt:mAb_1078|imgt:hasMabReceptor|imgt:IgG1-kappa_1078 imgt:Segment_369_1|rdfs:label|Segment_369_1 imgt:StudyProduct_ba68cbf7-54be-30f7-a6c5-c9bf8e34457e|imgt:hasClinicalPhase|imgt:Phase_I imgt:IgG4-kappa_402|rdf:type|imgt:MAbReceptor imgt:mAb_1273|rdfs:label|mAb_1273 imgt:mAb_509|imgt:imgt_note| anti-JL1 antibody: Lee G.K. et al. Molecules and Cells 9(6), 662-667 (1999) Agreement between 3SBio and DiNonA, 08/08/2014 imgt:StudyProduct_4c9fd200-e7af-3f10-9c46-515efc0feb2b|imgt:isStudyProductOf|imgt:Product_e055a0d3-71ff-3d4e-ad35-050d316b88bd imgt:Product_580ef4ed-4216-3856-a1a6-e16fceee2855|imgt:commun_name|RO6958688 imgt:mAb_325|imgt:hasImgtStructureEntry|imgt:9165 _:B53fc959bb30e419b52bb1fabad393937|rdf:type|obo:NCIT_C53285 imgt:Product_61d1bcf7-a2ee-33c8-8e6e-422bfd8da242|imgt:hasStudyProduct|imgt:StudyProduct_a3eeba9e-d742-3b4f-951f-bc3d277da478 imgt:mAb_434|imgt:hasBibliographicReference|pubmed:1279672 imgt:Sanofi|imgt:produces|imgt:Product_4e9f5192-76cf-34a3-82f3-78d812dbfd32 imgt:mAb_1262|imgt:hasMabReceptor|imgt:IgG1-kappa_1262 imgt:StudyProduct_c95dafd3-935a-3760-835a-d841566b1bdc|rdf:type|obo:NCIT_C174271 imgt:Lymphoma_B_cell|imgt:isClinicalIndicationOf|imgt:StudyProduct_ca2e917d-4310-3324-a891-cf35fce0d42a imgt:Construct_86|obo:BFO_0000051|imgt:Segment_86_1 imgt:mAb_1190|rdfs:label|mAb_1190 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_:B6f5ac89e30b4d10787f3eef5a9fa416a|rdf:type|obo:NCIT_C53285 imgt:StudyProduct_6414504d-ba2e-3495-8973-a96c0546b12d|rdf:type|obo:NCIT_C174271 imgt:mAb_816|imgt:inn_name|samrotamab imgt:Construct_788|imgt:isConstructOf|imgt:IgG1-kappa_788 imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_fb04dcf4-fa40-31d0-b04d-bb8c0ffd8ade imgt:Product_27f3c39d-c940-36e9-b77b-b5638fb484c9|imgt:isProducedBy|imgt:MacroGenics_Inc imgt:mAb_45|imgt:hasMabReceptor|imgt:IgG1-nd_45 _:Bf616e2d9b96503f718a2bdbc47609874|dc:date|1995-12-01 imgt:Construct_1076|rdfs:label|Construct_1076 imgt:IgG1-kappa_633|http://semanticscience.org/resource/SIO_000291|imgt:PTPRC imgt:IgG1-kappa_172|obo:RO_0002162|imgt:Homsap imgt:IgG1-kappa_720|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:IgG1-nd_46|http://semanticscience.org/resource/SIO_000291|imgt:ITGB2 obo:NCIT_C174933|rdf:type|owl:Class 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imgt:Product_311c7763-3fac-3098-84cc-61c90deca3aa|imgt:hasStudyProduct|imgt:StudyProduct_3458cf66-4c00-3212-b380-4a90977de6d5 imgt:Product_6fc221fc-63c6-300f-8844-5210f60014c6|rdfs:label|Product_6fc221fc-63c6-300f-8844-5210f60014c6 imgt:StudyProduct_beb58537-8503-3cb1-a6b2-0deccc1df0f7|rdfs:label|StudyProduct_beb58537-8503-3cb1-a6b2-0deccc1df0f7 imgt:mAb_964|imgt:inn_name|patritumab deruxtecan imgt:Product_6ea4a2cf-6e8c-3907-a97c-bdd8567e1143|imgt:isProducedBy|imgt:Bristol-Myers_Squibb imgt:mAb_258|rdfs:label|mAb_258 obo:ERO_0000405|rdfs:label|hasAcces imgt:FPIA_%5BPROTEIN_1DOMAIN_1CLIKE-PROTEIN_5DOMAINS_5F%5D2-FC_730|http://semanticscience.org/resource/SIO_000291|imgt:IL6R _:B771c4f0fee882b45fad53e8f860235e1|imgt:isDecidedBy|imgt:FDA imgt:StudyProduct_c44aacf9-e7e1-3fa0-b1f9-cadc07c21760|imgt:hasClinicalIndication|imgt:Cancers_gastrointestinal imgt:IgG1-lambda-PROTEIN_1296|obo:RO_0002162|imgt:Homsap _:Bd8b8f90a81d001c314586a6df2767368|imgt:isDecidedBy|imgt:FDA obo:NCIT_C157632|rdfs:subClassOf|obo:NCIT_C1909 imgt:Segment_1117_1|rdf:type|imgt:Segment _:B5ad7a6ec832e46209737e95c2f2391c4|rdf:type|obo:NCIT_C53285 imgt:Cardiopulmonary_bypass_(CPB)|rdf:type|obo:NCIT_C185637 imgt:IgG1-kappa-4lys-drug_357|imgt:hasMolecularComponent|imgt:IG imgt:herzuma™|rdfs:label|HERZUMA™ imgt:Lymphoma_follicular_(FL)|imgt:isClinicalIndicationOf|imgt:StudyProduct_b8543b44-c170-31d9-9985-bdcaa45b9a1d imgt:ESBATech|imgt:produces|imgt:Product_689cd79f-29d1-3d43-bdd9-edb405308805 _:B2940f36c870e7d879b4924b442c11232|imgt:isDecisionOf|imgt:StudyProduct_df2b1eee-0658-3294-a5a9-6de278413282 imgt:mAb_1099|imgt:hasProduct|imgt:Product_04ac483d-3770-31ee-be76-21b370f3667d imgt:StudyProduct_a1c85df1-9a7e-3cbb-8c9e-a8bcb6aaadd5|imgt:hasClinicalPhase|imgt:Preclinical imgt:mAb_410|imgt:hasProduct|imgt:Product_97984f90-666b-3255-b4ca-53dfa6fe9b05 imgt:F(ab%27)2-G1-kappa-PROT_906|http://semanticscience.org/resource/SIO_000291|imgt:SLC29A2 pubmed:3127726|dc:contributor|Clark M. 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imgt:IgG1-kappa_1146|imgt:hasMolecularComponent|imgt:IG imgt:9116|rdf:type|obo:NCIT_C25402 imgt:IgG2-nd_669|http://semanticscience.org/resource/SIO_000291|imgt:INSR imgt:IL17A|skos:definition|IL17A (interleukin 17A, IL-17A) imgt:IgG1-kappa_799|http://semanticscience.org/resource/SIO_000291|imgt:CD40 imgt:StudyProduct_85b6b72e-1238-3b69-a3e0-ce8bd39a5396|rdf:type|obo:NCIT_C174271 imgt:Segment_558_1|rdfs:label|Segment_558_1 imgt:IgG4-kappa_963|rdfs:label|IgG4-kappa_963 imgt:mAb_781|imgt:hasProduct|imgt:Product_02dd533d-4a92-33f2-bf63-c8a37a8c980f imgt:Segment_245_2|rdf:type|imgt:Segment imgt:StudyProduct_d571aff8-5be1-3eb0-9067-8bae72728f52|imgt:isStudyProductOf|imgt:Product_7ee1000f-7a38-3b1d-9440-c9f59adf1731 imgt:IgG1-kappa_349|obo:RO_0002162|imgt:Chi imgt:IgG2-lambda_944|obo:RO_0002162|imgt:Hum imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_aaed5428-4ace-3f83-8281-a25af9654b59 imgt:SCFV-KAPPA-HEAVY-CD8A-TNFRSF9-CD247|rdf:type|imgt:ChainLabels imgt:Segment_880_1|rdfs:label|Segment_880_1 imgt:mAb_454|imgt:inn_name|ozanezumab imgt:Clone_1224|rdf:type|obo:NCIT_C37925 imgt:Construct_1232|obo:BFO_0000051|imgt:Segment_1232_1 imgt:Construct_960|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:mAb_814|rdfs:label|mAb_814 imgt:Construct_739|imgt:hasImgtLabel|imgt:IgG1-kappa _:Bf47dd594eaeca346c211111e7c466421|imgt:isDecidedBy|imgt:FDA imgt:Product_26793454-2d17-3d3e-a99a-1648d65e5dd2|imgt:isProducedBy|imgt:Prima_BioMed imgt:Product_a8c8c8c2-d189-3ad8-a6d9-9c8f8d8c89c0|rdf:type|obo:NCIT_C51980 imgt:Clone_593|obo:RO_0002162|imgt:Musmus imgt:mAb_556|rdf:type|obo:NCIT_C152733 imgt:IG-MU_IOTA-2|rdfs:label|IG-MU_IOTA-2 imgt:scFv-scFv-scFc_kappa-lambda_1058|imgt:isMabReceptorOf|imgt:mAb_1058 imgt:Rabies_post-exposure|rdfs:label|Rabies_post-exposure imgt:Product_c84f1917-c6a8-30dd-aeaa-8815d874884c|imgt:commun_name|XOMA 358 imgt:Product_0567c1ec-d5f6-3399-831e-5021d15e29be|imgt:commun_name|RO7112689 imgt:IgG1-kappa_300|imgt:isMabReceptorOf|imgt:mAb_300 imgt:Product_8668df94-5bb9-3841-9139-21b5b8a00b95|imgt:commun_name|NVP-CSJ117 imgt:Construct_132|rdf:type|imgt:Construct imgt:Construct_70|imgt:isConstructOf|imgt:IgG3-nd_70 imgt:StudyProduct_dc26fde7-cb9d-3892-b45e-3a160680390a|imgt:application_type|Therapeutic imgt:Product_bfe41bf2-718f-3803-b385-cfc07fd9645d|imgt:isProducedBy|imgt:Merck_&_Co_Inc obo:NCIT_C171831|rdf:type|owl:Class imgt:Product_80543f95-22b7-3761-a574-ef4df0802d70|imgt:commun_name|Sym 004 (combination of modotuximab and futuximab) _:Bfd4ccb3393c1cb104f5dad0f77b93c56|rdf:type|obo:NCIT_C53285 imgt:Product_6082be18-1302-36ab-8a6c-75b884b65d62|imgt:commun_name|3772847-A imgt:V-CLUSTER|skos:definition|genomic DNA of an IG or TR locus, in germline configuration, including more than one V-GENE imgt:Segment_785_1|rdf:type|imgt:Segment imgt:11572|imgt:isImgtStructureEntryOf|imgt:mAb_1148 _:B4f59a5c8713a63eeb2695675c4dfd339|imgt:hasStatut|imgt:withdrawal imgt:IgG1-kappa-%5BPROTEIN%5D3_1224|imgt:isMabReceptorOf|imgt:mAb_1224 imgt:mAb_128|imgt:inn_name|afelimomab imgt:FGFR1|rdf:type|imgt:ChainLabels imgt:Product_565b4b15-341c-3c05-a51b-4245fd8756f8|rdf:type|obo:NCIT_C51980 imgt:StudyProduct_f03529af-62ae-377e-9f3a-4dae8ef40574|rdfs:label|StudyProduct_f03529af-62ae-377e-9f3a-4dae8ef40574 imgt:mAb_830|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=830 imgt:StudyProduct_59ea2587-d53c-3dd0-9bfb-2aaa90e0241a|imgt:application_type|Therapeutic imgt:mAb_4|imgt:hasMabReceptor|imgt:IgG1-nd_4 imgt:IgG4-kappa_1128|imgt:hasConstruct|imgt:Construct_1128 imgt:Construct_421|rdfs:label|Construct_421 imgt:INTEGRIN-ALPHA-X_BETA-2|skos:definition|Integring comprising an ALPHA-X and a BETA-2 chains imgt:11289|rdfs:label|11289 imgt:StudyProduct_1c304e20-ebb6-3cc3-9d92-318c71239249|imgt:hasClinicalPhase|imgt:Phase_I imgt:mAb_300|rdfs:label|mAb_300 imgt:Psoriatic_arthritis_(PSA)|rdf:type|obo:NCIT_C185637 imgt:StudyProduct_5e4bd1ba-5aaf-3593-8928-ee78cc13f6bb|imgt:hasClinicalPhase|imgt:Phase_M imgt:IgM-nd_112|imgt:hasMolecularComponent|imgt:IG imgt:mAb_295|imgt:hasImgtStructureEntry|imgt:9098 imgt:Product_ae24c953-5ef0-3ff3-9d24-34f1a89ee93f|imgt:commun_name|CIM 331 pubmed:9140729|dc:contributor|Tsuchiya M imgt:Product_645dae0f-4159-327b-abf7-586dd4526f26|imgt:commun_name|OM11-62MF imgt:StudyProduct_3fd941bf-0663-37c6-81e0-47e586d03fba|imgt:hasClinicalIndication|imgt:Allograft_rejection imgt:mAb_177|rdf:type|obo:NCIT_C126841 imgt:mAb_76|imgt:hasImgtStructureEntry|imgt:3GKW imgt:IgG1-kappa_24|obo:RO_0002162|imgt:Hum imgt:IG-MU_KAPPA_J-CHAIN|imgt:describes|imgt:IgM_Kappa_J-chain imgt:Product_7fff9d3d-ea92-356d-86ba-ac6cbbbf10dd|imgt:hasStudyProduct|imgt:StudyProduct_b88b5151-dab0-3155-94aa-86dc1a096227 imgt:StudyProduct_15a257d3-e7cf-393d-9482-4fadc2a060bb|rdfs:label|StudyProduct_15a257d3-e7cf-393d-9482-4fadc2a060bb imgt:mAb_60|rdfs:label|mAb_60 imgt:FAB-GAMMA-3_KAPPA|skos:definition|Fab comprising the VH-CH1 domains from a H-GAMMA-3 chain and a L-KAPPA chain imgt:mAb_462|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=462 imgt:StudyProduct_1b47dcca-8b27-33c3-b6b2-d9c5cd3d4a8b|rdfs:label|StudyProduct_1b47dcca-8b27-33c3-b6b2-d9c5cd3d4a8b imgt:Chronic_lymphocytic_leukemia_(CLL)|imgt:isClinicalIndicationOf|imgt:StudyProduct_2008f384-31a8-376e-b845-ed89359b18eb imgt:Segment_1276_1|rdf:type|imgt:Segment imgt:StudyProduct_52c977a0-d7e8-34e4-94d4-a8442f8eb205|imgt:isStudyProductOf|imgt:Product_2617d7d5-76ab-3d60-b161-b32038696bd6 imgt:mAb_546|rdfs:label|mAb_546 imgt:12014|rdfs:label|12014 imgt:FGF21|rdf:type|imgt:ChainLabels imgt:PROTEIN_1DOMAIN-PEG_871|imgt:isMabReceptorOf|imgt:mAb_871 imgt:Segment_335_1|rdf:type|imgt:Segment imgt:Segment_1132_1|imgt:has_rank|1 imgt:Osteoarthritis_(OA)|imgt:isClinicalIndicationOf|imgt:StudyProduct_a177bffd-41d0-3b50-81c9-05cfc8a63c34 pubmed:21330330|dc:contributor|Montagna M imgt:IgG4-kappa_1038|rdf:type|imgt:MAbReceptor imgt:StudyProduct_03af0f5d-1eda-3547-bc46-fa9829250b8e|imgt:isStudyProductOf|imgt:Product_ce798bcc-59a1-30cb-9b81-5631c8ca8029 imgt:mAb_1225|imgt:hasOriginClone|imgt:Clone_1225 imgt:Segment_436_1|rdfs:label|Segment_436_1 _:B5b2a64551ee0ebcae056426b0edcf622|imgt:isDecisionOf|imgt:StudyProduct_ffeb1ca9-c9e8-34f6-83ea-618ca732e826 imgt:3HMX|rdf:type|obo:NCIT_C25402 imgt:Segment_13_1|imgt:has_rank|1 imgt:ExonLabel|rdfs:label|ExonLabel imgt:IG-Heavy-Gamma-2-a-IGHG2A|rdf:type|imgt:GeneLevelChainType pubmed:27310493|dc:contributor|Nylander S imgt:mAb_920|rdfs:label|mAb_920 imgt:9788|rdf:type|obo:NCIT_C25402 imgt:mAb_194|rdf:type|obo:NCIT_C66952 imgt:Product_a22e1e73-39c4-3d58-810c-61a5fe2f2b92|imgt:isProducedBy|imgt:Systimmune_Inc imgt:mAb_1193|imgt:hasMabReceptor|imgt:IgG1-kappa_1193 imgt:Acceleron_Pharma_Inc|rdfs:comment|Cambridge , UK imgt:%5BPEPTIDE%5D2-FC_394|obo:RO_0002162|imgt:Homsap imgt:IgG1-nd_MM_281|imgt:hasConstruct|imgt:Construct_281 imgt:Fc_receptor|rdf:type|owl:Class imgt:StudyProduct_79674173-710e-37b3-a168-683145b9f131|rdfs:label|StudyProduct_79674173-710e-37b3-a168-683145b9f131 imgt:TRANSMEMBRANE-REGION|skos:definition|Coding region of the transmembrane region between an EXTERNAL-REGION (or a CONNECTING-REGION (CO)) and a CYTOPLASMIC-REGION (CY) for membrane chains imgt:StudyProduct_d41ca359-aa1c-3268-92de-4b4fdced0802|imgt:hasClinicalIndication|imgt:Low_bone_mineral_density imgt:Product_3fbfe977-f5f9-381b-94d0-489e229f2eaf|imgt:hasStudyProduct|imgt:StudyProduct_1e66469a-48de-359d-b4b4-9988990dbe25 imgt:Construct_1279|imgt:isConstructOf|imgt:IgG1-kappa_1279 imgt:VH-CD3E_1101|rdf:type|imgt:MAbReceptor imgt:Construct_683|imgt:isConstructOf|imgt:PROTEIN_1DOMAIN_683 imgt:StudyProduct_c140069a-d122-321f-92f1-8174f4f5b5ce|imgt:application_type|Therapeutic imgt:StudyProduct_a3efdb33-e7a0-3712-96a4-1d95f7771e48|imgt:development_technology| Human antibody phage display library imgt:StudyProduct_89d67e9e-5652-3242-849d-9e5fddff6c8c|imgt:development_technology| VelocImmune® imgt:11341|rdf:type|obo:NCIT_C25402 imgt:IgG2-kappa_1064|imgt:hasConstruct|imgt:Construct_1064 imgt:Construct_229|rdf:type|imgt:Construct imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_6395a513-b609-3c18-91ed-2389e408549b imgt:Product_5bdd4781-1f7e-3d2a-a7f9-bebb5a59b8db|imgt:commun_name|RVT-1401 obo:NCIT_C95768|rdfs:subClassOf|obo:NCIT_C1909 imgt:11575|rdfs:label|11575 imgt:IgG2a-nd_989|rdf:type|imgt:MAbReceptor imgt:Cancers|imgt:isClinicalIndicationOf|imgt:StudyProduct_b36541b6-ed7b-3042-8d5d-b27eb1b0b96a imgt:StudyProduct_85b6b72e-1238-3b69-a3e0-ce8bd39a5396|imgt:isStudyProductOf|imgt:Product_2ac5f9dd-3aa5-3b90-9b7c-53e60c91c010 imgt:Product_f4537a5a-2150-3510-bb0d-59579f1d38f7|imgt:isProductOf|imgt:mAb_618 _:B99b31bb8918c7136ac510c1bf3a24755|imgt:isDecisionOf|imgt:StudyProduct_a5fee61c-61c3-387f-b88a-915bf034be05 imgt:MAbReceptor_35|rdf:type|imgt:MAbReceptor imgt:mAb_678|imgt:inn_name|garetosmab imgt:Product_95973100-5a45-3d50-9924-c8932582e63b|imgt:commun_name|ASKP1240 imgt:StudyProduct_50058744-0407-35c4-83b5-68796a196f8e|imgt:hasClinicalPhase|imgt:Phase_I imgt:Segment_850_1|obo:BFO_0000050|imgt:Construct_850 imgt:mAb_486|imgt:inn_recommended_list|72 (2014) imgt:6C-LIKE|rdfs:label|6C-LIKE imgt:Segment_1298_1|imgt:segment_detail|fragment (1-715) imgt:FPIA_%5BPROTEIN%5D2-FC_1162|rdfs:label|FPIA_[PROTEIN]2-FC_1162 imgt:scFv-scFv-scFc_kappa-lambda_1192|rdf:type|imgt:MAbReceptor imgt:Product_0fde4219-157b-371f-b21d-de9bd50d98fe|rdfs:label|Product_0fde4219-157b-371f-b21d-de9bd50d98fe imgt:MAbReceptor_35|rdfs:label|MAbReceptor_35 imgt:StudyProduct_f194b2c1-54af-36a1-9743-5293ec4e34ae|imgt:isStudyProductOf|imgt:Product_456d564b-7ac0-3592-8ca9-cd2dfb44a72d imgt:10948|rdfs:label|10948 imgt:mAb_1180|imgt:hasProduct|imgt:Product_b040dae5-3608-32e1-b3f2-9802ffb17c21 imgt:Product_555d6702-c950-3cb7-a9a9-66504af0a635|imgt:commun_name|CAR RN 894777-94-7 imgt:mAb_135|imgt:inn_name|milatuzumab imgt:Short_bowel_syndrome_(SBS)|imgt:isClinicalIndicationOf|imgt:StudyProduct_670de969-0702-323b-94f9-41ae8f7a1d2b imgt:mAb_463|rdf:type|imgt:INN _:B52fb77b57f31eb622ec9cb0915cd9dee|imgt:isDecidedBy|imgt:FDA imgt:Janssen_Biotech_Inc|imgt:produces|imgt:Product_6de5e4cc-b4a5-392b-a018-f88bb89a8395 imgt:JCR_Pharmaceuticals_Co_Ltd|rdf:type|obo:NCIT_C54131 imgt:Product_5aa125c5-8555-3956-8257-050ead9813df|rdfs:label|Product_5aa125c5-8555-3956-8257-050ead9813df imgt:mAb_1279|imgt:hasImgtStructureEntry|imgt:12159 imgt:Product_3adee3e6-6ae0-336d-9a0a-2290f3ed968a|imgt:hasStudyProduct|imgt:StudyProduct_f96588b4-d3c1-35cb-b6d7-f2867a3f3bbe imgt:mAb_585|imgt:hasImgtStructureEntry|imgt:10037 imgt:Segment_197_1|imgt:has_rank|1 imgt:IgG1-lambda_811|obo:RO_0002162|imgt:Hum imgt:Construct_1286|imgt:isConstructOf|imgt:IgG1-Fab-kappa-lambda_1286 imgt:mAb_462|rdfs:label|mAb_462 imgt:CARRIER_BIG-PROTEIN_1DOMAIN_399|rdfs:comment|CARRIER_BIG-PROTEIN_1DOMAIN imgt:Pathology_Dept_University_of_Cambridge|rdfs:label|Pathology Dept., University of Cambridge imgt:Product_df0ac1b0-8a39-3381-9008-b780610f2bcc|imgt:hasStudyProduct|imgt:StudyProduct_1b9cec3d-d541-35a3-ba0f-add2fb0637da _:B06749efdf1238d3379a5e910bc0c8743|dc:date|2015-10-07 imgt:Segment_1157_1|imgt:hasImgtLabel|imgt:IgG1-kappa _:B2c99553dcff1c2ba4133a517e07f1451|imgt:isDecisionOf|imgt:StudyProduct_b0858c8e-e130-3de5-8485-057e1651450c imgt:shiga_toxin_type_2|rdfs:label|shiga toxin type 2 imgt:SCFV-KAPPA-HEAVY-SCFV-KAPPA-HEAVY-CD4|skos:definition|Chain or receptor comprising 2 SCFV-KAPPA-HEAVY and CD4 imgt:mAb_421|imgt:inn_name|lampalizumab imgt:mAb_603|rdf:type|obo:NCIT_C170200 imgt:Product_16aae7ef-cb35-3b16-8b5b-31224a407d63|imgt:commun_name|Factor IX-XTEN imgt:IgG1-kappa_837|imgt:hasMolecularComponent|imgt:IG imgt:Colon_sarcoma|rdf:type|obo:NCIT_C185637 imgt:IgG1-kappa-4cys-drug_1269|obo:RO_0002162|imgt:Hum imgt:StudyProduct_d45b483c-0c49-395a-bcab-dce618341e33|imgt:hasClinicalIndication|imgt:Non-Hodgkin's_lymphoma_(NHL) imgt:mAb_1094|imgt:hasMabReceptor|imgt:IgG1-kappa_1094 imgt:StudyProduct_0c7ee8f9-4c1b-3cde-8730-1e8dba0c23f9|imgt:hasDecision|_:Bf861a4ab8dddc6a38ff1cdb522686aba imgt:FUSION-FC-GAMMA-1|rdf:type|imgt:StructureLabels obo:NCIT_C1784|rdfs:subClassOf|obo:NCIT_C1909 imgt:mAb_629|imgt:inn_recommended_list|71 (2014) imgt:IgG1-kappa_771|imgt:isMabReceptorOf|imgt:mAb_771 imgt:Construct_864|rdf:type|imgt:Construct imgt:StudyProduct_997755ec-78d1-3d75-80b4-20ca997666bc|imgt:application_type|Therapeutic _:B93b982c8133b4b67997e1f61b6da4378|imgt:isDecisionOf|imgt:StudyProduct_470fba3c-c13f-3b6a-b2a8-d44d7213ccc6 imgt:Product_9237ba2c-b159-341d-95ed-b48c5afa0ee8|imgt:hasStudyProduct|imgt:StudyProduct_a30aa114-76b9-3dfd-aeb4-317ad0368396 imgt:mAb_59|imgt:imgt_note| Discontinued March 22, 2004, for hematological cancer (USA, Europe) imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_3af4fc94-a470-31a6-b10b-f0a9c38ec2f9 _:Bc658917cb2b13c0bf2036cecea05a62e|imgt:hasDesignation|imgt:Orphan_drug imgt:FC-%5BPEPTIDE-PEPTIDE%5D2_393|imgt:hasMolecularComponent|imgt:CPCA imgt:IgG2a-nd_159|rdf:type|imgt:MAbReceptor imgt:Product_fb6a4cf5-bcaa-3a19-a998-f725027ec39c|imgt:hasStudyProduct|imgt:StudyProduct_6ac7279d-e1eb-3033-9958-2641b6a0199d imgt:PEPTIDE_710|imgt:hasConstruct|imgt:Construct_710 imgt:StudyProduct_4e6bde7e-d321-3797-854b-8b18ca0ae17f|imgt:application_type|Therapeutic imgt:mAb_1265|imgt:imgt_note| XpressCF® technology, developed by Sutro Biopharma, provides a cell-free bacterial expression for therapeutic proteins. XpressCF® also enables a non-natural amino acid conjugation technology XpressCF+™. The Fc is aglycosylated. imgt:Melanoma_metastatic|imgt:clinical_domain|Oncology imgt:mAb_283|rdfs:label|mAb_283 imgt:IgG1-kappa_1000|http://semanticscience.org/resource/SIO_000291|imgt:VTCN1 imgt:Product_1bf8b5fc-da79-3672-80d7-057ce5208e1d|imgt:commun_name|CEP-37247 imgt:IgG1-nd_93|rdfs:label|IgG1-nd_93 imgt:StudyProduct_e74e6492-ccee-3cfe-984b-10204f242972|imgt:hasClinicalPhase|imgt:Phase_I imgt:11690|rdfs:label|11690 imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_bff647af-97f0-3130-ad25-6db937cf9c00 obo:NCIT_C135632|rdfs:subClassOf|obo:NCIT_C1909 imgt:Segment_691_1|rdfs:label|Segment_691_1 imgt:Segment_214_2|rdf:type|imgt:Segment imgt:mAb_1112|imgt:hasMabReceptor|imgt:IgG4-kappa_1112 imgt:Construct_531|rdfs:label|Construct_531 imgt:AVEO_Pharmaceuticals|rdf:type|obo:NCIT_C54131 imgt:StudyProduct_55cfd2bc-f333-3988-bf8a-59946f82228d|imgt:hasClinicalIndication|imgt:Myeloid_leukemia imgt:9045|rdf:type|obo:NCIT_C25402 imgt:IgG1-lambda-3lys-drug_471|obo:RO_0002162|imgt:Homsap imgt:Cubist_Pharmaceuticals_Inc|imgt:produces|imgt:Product_410df2c2-31fc-38b5-a007-2574a4c85dde imgt:Product_69126e38-2f0c-3448-b499-cabc3ca17145|imgt:isProductOf|imgt:mAb_925 imgt:StudyProduct_325e5cda-6137-3a4e-80fe-43c7609968e4|rdfs:label|StudyProduct_325e5cda-6137-3a4e-80fe-43c7609968e4 imgt:Incyte_Corporation|rdfs:label|Incyte Corporation imgt:Construct_636|imgt:isConstructOf|imgt:PROTEIN_1DOMAIN-PEG_636 imgt:mAb_639|imgt:clinical_trials|402 studies found, 40 recruiting imgt:ANPEP|rdfs:label|ANPEP imgt:mAb_368|rdfs:label|mAb_368 imgt:StudyProduct_cce1cf27-9062-3c21-b311-6b2c23f33ced|imgt:application_type|Therapeutic imgt:mAb_633|rdf:type|obo:NCIT_C2527 imgt:Product_c85dbcd7-b2a5-315e-880f-d1ba52bd5d6c|imgt:hasStudyProduct|imgt:StudyProduct_a8d4d541-9193-3ea5-a4f1-395c76adefc8 imgt:StudyProduct_29f68c3f-6531-3a40-a091-1f002b14d6b7|rdfs:label|StudyProduct_29f68c3f-6531-3a40-a091-1f002b14d6b7 imgt:10922|rdf:type|obo:NCIT_C25402 imgt:IgG1-kappa-4lys-drug_357|http://semanticscience.org/resource/SIO_000291|imgt:ERBB2 imgt:IgD_Lambda|imgt:isDefinedBy|imgt:IG-Heavy-Delta-IGHD imgt:mAb_1035|imgt:hasProduct|imgt:Product_35d43e20-c6a7-3527-ab9d-4663956b201d imgt:Cancers|rdf:type|obo:NCIT_C185637 imgt:IG-Heavy-Alpha|imgt:isDescribedBy|imgt:H-ALPHA imgt:Segment_269_1|obo:BFO_0000050|imgt:Construct_269 imgt:Segment_704_1|imgt:has_rank|1 imgt:NantCell_Inc|rdfs:label|NantCell, Inc. imgt:IgG1-kappa_907|obo:RO_0002162|imgt:Chi imgt:CR1_(Pr42-101)|rdf:type|imgt:DomainLabel imgt:Eli_Lilly|rdf:type|obo:NCIT_C54131 imgt:StudyProduct_e0e65127-cd8a-35e9-b6fc-6731cbf22051|imgt:hasClinicalIndication|imgt:Psoriasis imgt:Segment_82_5|rdf:type|imgt:Segment imgt:StudyProduct_94fd6c18-f98f-3ee1-acea-07361913e4d2|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:StudyProduct_e09ced69-a82d-3408-a2f1-7c8527eafb37|rdfs:label|StudyProduct_e09ced69-a82d-3408-a2f1-7c8527eafb37 imgt:TNFRSF9|imgt:isTargetOf|imgt:IgG4-kappa-protein_982 imgt:Product_80c5a255-5aa4-3782-9556-7a0618ee7c39|imgt:commun_name|Fc-EDA imgt:VH-VH%27-VH_trivalent|imgt:construction_detail|VH - VH' - VH, trivalent imgt:IgG1-kappa_135|obo:RO_0002162|imgt:Hum imgt:mAb_914|imgt:inn_number|10995 imgt:IgG4-kappa_1131|imgt:isMabReceptorOf|imgt:mAb_1131 imgt:IgG4-kappa-lambda_1183|imgt:isMabReceptorOf|imgt:mAb_1183 imgt:CARsgen_Therapeutics|rdfs:label|CARsgen Therapeutics imgt:IG-Heavy-Mu-IGHM|imgt:hasChainTypeLevel|imgt:IG-Heavy-Mu imgt:mAb_869|rdf:type|imgt:INN imgt:Active_Biotech_AB|rdfs:comment|Lund , Sweden imgt:Clone_216|rdfs:label|Clone_216 imgt:StudyProduct_2250d796-5209-3656-9e42-4c6269186b55|imgt:isStudyProductOf|imgt:Product_052222ca-ca92-3ed7-9db6-36ad6b246584 _:Bceb6846f88f8137559d51d94d4e861de|imgt:isDecisionOf|imgt:StudyProduct_2d5ce8c9-7700-3e05-b6c2-4d613c31d3ce imgt:Nexvet_Biopharma|imgt:produces|imgt:Product_c2b74f26-c515-3914-959f-027a6506d450 imgt:StudyProduct_1b94f691-ab12-3c1b-b53c-7e368c926c91|imgt:hasClinicalPhase|imgt:Phase_I imgt:IgG1-kappa_MM_225|obo:RO_0002162|imgt:Musmus imgt:KaloBios_Pharmaceuticals_Inc|imgt:produces|imgt:Product_da697f5a-1938-3687-a103-54610aa291dd imgt:IgG1-kappa_1104|imgt:isMabReceptorOf|imgt:mAb_1104 imgt:StudyProduct_caefcc10-c9e9-3bb3-8576-158012138944|rdf:type|obo:NCIT_C174271 imgt:mAb_1144|rdfs:label|mAb_1144 pubmed:16699037|dc:contributor|Yamamoto N imgt:Segment_1043_1|rdfs:label|Segment_1043_1 imgt:StudyProduct_39b3999c-d6e1-3a37-b0cb-7f6ed4baf430|rdf:type|obo:NCIT_C174271 imgt:Bone_loss_in_cancer|imgt:clinical_domain|Oncology imgt:IL20|rdfs:label|IL20 imgt:mAb_1072|imgt:hasMabReceptor|imgt:IgG1-kappa-1cys_N84.4-drug_1072 imgt:StudyProduct_82fd7c74-ea4a-3e37-ba9a-116be9109767|imgt:isStudyProductOf|imgt:Product_cef966d9-7220-3c3b-8d4c-3695c4e55488 imgt:MAbReceptor_514|rdf:type|imgt:MAbReceptor imgt:mAb_1104|imgt:inn_proposed_list|124 (2020) imgt:Segment_146_1|imgt:hasImgtLabel|imgt:Fab-G1-kappa imgt:CH9|rdfs:label|CH9 imgt:StudyProduct_1fd5cdac-9470-3ccd-b72e-92d15d0578c1|imgt:application_type|Therapeutic _:B2bd1b93c3177d02e1c9035b5a0f30450|imgt:isDecisionOf|imgt:StudyProduct_c8410db6-e214-3133-9a26-8eee32338034 imgt:Kidney_transplantation_treatment_of_antibody-mediated_rejection_(AMR)|imgt:clinical_domain|Immunology imgt:IgG2-nd_100|imgt:isMabReceptorOf|imgt:mAb_100 imgt:Construct_244|obo:BFO_0000051|imgt:Segment_244_1 imgt:StudyProduct_a537c635-1641-3b72-aee4-80c8bf5556d3|imgt:application_type|Therapeutic imgt:ERBB2|imgt:isTargetOf|imgt:G1-kappa_scFv-h-CH2-CH3_1075 imgt:IgG4-kappa_595|http://semanticscience.org/resource/SIO_000291|imgt:GCGR imgt:StudyProduct_9c183f9a-f7c6-3dae-9a94-72c549974afd|imgt:hasClinicalIndication|imgt:Systemic_sclerosis imgt:I-ALPHA-LIKE|skos:definition| imgt:StudyProduct_6e1d6f70-6543-3bce-a73d-eacbc56df1a3|imgt:hasClinicalPhase|imgt:Phase_M imgt:FUSION-%5BCSF3%5D2-FC-GAMMA-4|skos:definition|Fusion protein for immune application (FPIA) comprising CSF3 fused with immunoglobulin G4 FC fragment imgt:Construct_1058|rdfs:label|Construct_1058 imgt:Colitis_ulcerative_(UC)_pediatric|imgt:isClinicalIndicationOf|imgt:StudyProduct_1c6128ec-af87-317b-8acd-7724368de5cb imgt:StudyProduct_6531837b-e221-3c84-b29d-98740ad35007|imgt:isStudyProductOf|imgt:Product_e5ca6245-7a11-3390-b7de-6b5e8870b2ab imgt:StudyProduct_2b5823b9-ed23-3d5a-b882-138c8f1a4919|imgt:hasClinicalIndication|imgt:Neuromyelitis_optica_(NMO) imgt:F(AB%27)2-GAMMA-2B_LAMBDA|rdfs:label|F(AB')2-GAMMA-2B_LAMBDA imgt:%5B(scFv-heavy-kappa)-IGHE-CH4%5D2_370|rdfs:comment|[(scFv - heavy - kappa) - IGHE - CH4]2 imgt:mAb_921|imgt:inn_number|11022 imgt:CSF2RA|rdf:type|obo:NCIT_C25702 imgt:Product_dd7c53c2-e62e-38a6-89d3-770f9d73c78c|imgt:hasStudyProduct|imgt:StudyProduct_bfac3108-ff6d-3d7a-8598-e41a89114546 imgt:Product_efb61065-7b20-3c3c-a956-d520973c84fe|imgt:commun_name|CEA-Scan imgt:IG-Light-Kappa-IGKC|imgt:defines|imgt:F(ab’)2-Gamma-4_Kappa imgt:Genzyme_Corp|rdfs:comment|Cambridge , USA imgt:StudyProduct_5f4b56c5-0c22-3e10-b1fa-52d055ad6dc3|rdfs:label|StudyProduct_5f4b56c5-0c22-3e10-b1fa-52d055ad6dc3 imgt:IgG2-kappa_332|rdfs:label|IgG2-kappa_332 _:B4fb63670f93b9bfef4dea607dc7c7341|dc:date|2017-11-14 imgt:Product_5994f2d0-2c12-3fdb-820c-747cc0c851a0|imgt:isProductOf|imgt:mAb_182 _:B4103f5cbd4051fba6a90b669b74496e1|dc:date|2014-05-22 imgt:Segment_607_1|imgt:has_rank|1 imgt:StudyProduct_bcd3d4d4-ac07-39e5-87b1-8595fdb28d97|imgt:hasClinicalIndication|imgt:Solid_tumors imgt:Product_4f2c7bb9-ac84-38a9-a855-f2b4fa32ea2a|imgt:hasStudyProduct|imgt:StudyProduct_8037ac88-b353-3582-afaf-b797db588a1b pubmed:17240489|dc:contributor|Rowley KJ imgt:StudyProduct_091e9164-e035-30ba-8dc9-ce4d71dec71a|imgt:application_type|Therapeutic imgt:Construct_1271|rdf:type|imgt:Construct imgt:GlaxoSmithKline|imgt:produces|imgt:Product_5b521ec1-570f-3ff9-9c71-ed3bea3e4f23 _:Bbaa7c693ecd00ec56c00893dba22c7ae|imgt:hasStatut|imgt:approval imgt:mAb_1059|imgt:hasProduct|imgt:Product_36113e7c-404a-35ad-8f60-78bdc8d88db9 imgt:StudyProduct_f765eebb-5180-3806-84f0-27613a9fb127|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:StudyProduct_ca74b2ab-9fdc-32f2-be20-efd735882d1b|imgt:isStudyProductOf|imgt:Product_6bc1d7d7-3572-3445-908f-a32d9aa7218d imgt:StudyProduct_75eda263-39ba-3780-ac7c-496483d2d44a|imgt:hasClinicalPhase|imgt:Phase_M imgt:Product_b353bcb4-76c4-3d6a-8bca-4d0445e74563|imgt:commun_name|RO4858696-000 imgt:Immunocore_Ltd|rdfs:label|Immunocore Ltd imgt:VH-V-kappa-CH2-CH3_488|imgt:isMabReceptorOf|imgt:mAb_488 imgt:Construct_1196|obo:BFO_0000051|imgt:Segment_1196_1 imgt:Segment_214_2|obo:BFO_0000050|imgt:Construct_214 imgt:Product_4eb1994b-05ee-3d18-a5e3-e16b2601a5cd|imgt:commun_name|CDP-771 imgt:IgG4-kappa_496|imgt:isMabReceptorOf|imgt:mAb_496 imgt:Product_7e7c38e2-9e8a-39d1-9b8a-c54308b16be4|imgt:hasStudyProduct|imgt:StudyProduct_4e6bde7e-d321-3797-854b-8b18ca0ae17f imgt:TNFRSF1A|rdfs:label|TNFRSF1A imgt:IgG4-kappa_1038|imgt:isMabReceptorOf|imgt:mAb_1038 imgt:mAb_373|rdfs:label|mAb_373 imgt:mAb_236|imgt:inn_number|9046 imgt:Construct_398|imgt:hasImgtLabel|imgt:%5BAPP_(amyloid_beta_A4_precursor_protein)_Abeta_1-7_peptide_672-678%5D15-CRM197_(vaccine_carrier) imgt:StudyProduct_baec2f65-4160-3b27-b529-a70a14c5af0f|imgt:hasDecision|_:B920b1cef6961176ca2f76fd1811cee1c imgt:IgG1-kappa_1088|rdfs:comment|IgG1 - kappa imgt:Cancers_breast|imgt:isClinicalIndicationOf|imgt:StudyProduct_8b843fa5-61a4-3e1c-8856-51d838be7868 imgt:mAb_311|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=311 imgt:StudyProduct_506a8738-be67-31c5-b7a4-40d5065a88ce|rdf:type|obo:NCIT_C174271 pubmed:8769601|dc:contributor|DiCicco R obo:GENO_0000251|rdfs:domain|obo:GENO_0000702 imgt:Segment_1156_2|imgt:has_rank|2 _:B5b16c0c058e26e6347d7a95a087952e5|rdf:type|obo:NCIT_C53285 imgt:StudyProduct_bee8e0d7-239d-3f40-882c-e26a3de7e64c|imgt:application_type|Therapeutic obo:NCIT_C166445|rdfs:subClassOf|obo:NCIT_C1909 imgt:mAb_359|imgt:imgt_note| Centocor is Janssen Biotech Inc., a subsidiary of Johnson & Johnson. Press release imgt:_Sp2/0_mouse_hybridoma_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_73eadf4f-ba04-320b-ad70-ae2133e4211b imgt:FPIA_%5BPROTEIN_1REPEAT%5D2-FC_246|http://semanticscience.org/resource/SIO_000291|imgt:TNFSF13B imgt:MAbReceptor_110|http://semanticscience.org/resource/SIO_000291|imgt:FOLH1 imgt:StudyProduct_fb049423-02a4-3c71-b284-29932cb38182|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_f8165c2a-c428-34fe-98e3-63643d767d39|rdfs:label|StudyProduct_f8165c2a-c428-34fe-98e3-63643d767d39 imgt:H-GAMMA-1-TGFBR2|rdf:type|imgt:ChainLabels imgt:Solid_tumors|imgt:isClinicalIndicationOf|imgt:StudyProduct_e9a7c8f3-f7cf-359e-b817-11dba4592ec9 imgt:Staphylococcus_epidermidis_lipoteichoic_acid|obo:RO_0002162|imgt:Staepi imgt:Psoriasis_moderate_to_severe_plaque|imgt:isClinicalIndicationOf|imgt:StudyProduct_d6fc8e97-e1e0-3a49-b197-dc6a965d5e02 imgt:StudyProduct_03d846e7-d938-3ce8-bd8c-d7891404f43f|rdfs:label|StudyProduct_03d846e7-d938-3ce8-bd8c-d7891404f43f imgt:mAb_1121|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=1121 imgt:IG-Heavy-Gamma-3-IGHG3|imgt:isDescribedBy|imgt:CH2-CH3 imgt:Clone_1282|rdf:type|obo:NCIT_C37925 imgt:StudyProduct_8f2a8683-570a-3ebe-a0f8-26876a22ad5a|rdfs:label|StudyProduct_8f2a8683-570a-3ebe-a0f8-26876a22ad5a imgt:Product_6956a607-0f47-33a7-bdff-92b6edef93c2|imgt:commun_name|BIVV001 imgt:Molecule_StructureType|protege:protege#subclassesDisjoint|true imgt:StudyProduct_c705bca7-5973-3e15-87f9-106e3fa87b06|imgt:application_type|Therapeutic imgt:Segment_271_1|imgt:has_rank|1 imgt:mAb_613|rdf:type|imgt:INN imgt:StudyProduct_91667898-e331-3f72-aafb-77e31f239f70|imgt:hasClinicalPhase|imgt:Phase_II imgt:mAb_675|imgt:hasImgtStructureEntry|imgt:11044 imgt:Product_a8d25997-7723-31d5-9058-736b698e9a58|imgt:commun_name|RVT-1401 imgt:Non-Hodgkin's_lymphoma_(NHL)|imgt:isClinicalIndicationOf|imgt:StudyProduct_426edf19-0f27-3402-9751-dc7a27c88838 imgt:mAb_307|imgt:inn_recommended_list|38 (1997) imgt:StudyProduct_99e41e99-17fa-3964-97db-50031ea146cb|rdf:type|obo:NCIT_C174271 imgt:Fab-G2a-kappa_124|imgt:isMabReceptorOf|imgt:mAb_124 imgt:IgG1-kappa-%5BscFv%5D2-lambda_545|rdfs:label|IgG1-kappa-[scFv]2-lambda_545 imgt:StudyProduct_b5c12b2c-3e4c-373e-aa68-cadfb8ccd5f9|imgt:isStudyProductOf|imgt:Product_b5c12b2c-3e4c-373e-aa68-cadfb8ccd5f9 imgt:PROTEIN_1DOMAIN_684|imgt:hasConstruct|imgt:Construct_684 imgt:IgG1-kappa_79|obo:RO_0002162|imgt:Hum imgt:Product_3b1928d9-c353-3e4e-b423-fe0d01fedf38|imgt:hasStudyProduct|imgt:StudyProduct_c530d1d3-2c88-3698-a7d7-b829340f11ff imgt:IgM_Kappa|imgt:isDefinedBy|imgt:IG-Light-Kappa-IGKC imgt:G-ALPHA1|rdf:type|imgt:RegionLabel imgt:Segment_742_1|rdfs:label|Segment_742_1 imgt:Prurigo|rdf:type|obo:NCIT_C185637 imgt:Construct_971|imgt:isConstructOf|imgt:VH-VH%27-VH__trivalent_971 imgt:StudyProduct_0be86c1d-c760-383a-8925-0c1bdd77caa5|rdfs:label|StudyProduct_0be86c1d-c760-383a-8925-0c1bdd77caa5 imgt:Construct_99|rdf:type|imgt:Construct imgt:Construct_1088|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:NRP1|obo:RO_0002162|imgt:Homsap imgt:Novartis_Pharmaceuticals_Corp|imgt:produces|imgt:Product_87b3f496-ef6a-35d5-9b27-f8d2bffe7e59 imgt:mAb_449|imgt:imgt_note| On May 6, 2011, Sanofi-Aventis simplified its name to Sanofi. imgt:StudyProduct_fe029148-b943-335c-8af0-e7fe24d86ee1|imgt:application_type|Therapeutic imgt:mAb_9|imgt:hasProduct|imgt:Product_68b98f78-23f2-3109-8dac-c2bf17514d02 imgt:TNFRSF8|imgt:isTargetOf|imgt:scFv-heavy-kappa-IgG1-h-CH2-CH3(CO)-CD28(TM-CY1)-CD247(CY2)_1234 imgt:StudyProduct_54430c50-7ea4-373d-be19-5cb1bfadd006|imgt:application_type|Therapeutic imgt:Product_0348fc3a-dd69-3bf2-bb93-d6d2b096d5f2|imgt:commun_name|MT110 imgt:StudyProduct_6d2b9607-0f54-334f-9a71-2538aca2b433|imgt:isStudyProductOf|imgt:Product_6c447d00-9687-350a-8e55-ee7ab8c6a1dd obo:NCIT_C184904|rdfs:subClassOf|obo:NCIT_C1909 imgt:Segment_1290_1|obo:BFO_0000050|imgt:Construct_1290 imgt:IgG1-kappa_463|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:Wilex_AG|imgt:produces|imgt:Product_73e835ec-f2f0-3c7f-9278-25c653d1147e imgt:%5BALPL_(alkaline_phosphatase_TNSALP_tissue_non-specific_alkaline_phosphatase)_18-502%5D2-IGHG1_Fc_(Fragment_constant)-Asp-Ile-deca-aspartate|rdfs:label|[ALPL (alkaline phosphatase, TNSALP, tissue non-specific alkaline phosphatase) 18-502]2 - IGHG1 Fc (Fragment constant) - Asp-Ile-deca-aspartate imgt:Construct_644|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Segment_392_1|imgt:hasImgtLabel|imgt:SELPLG imgt:mAb_757|rdf:type|obo:NCIT_C121775 imgt:StudyProduct_be8f763d-e2cf-38ad-b706-3f7ae2c239f9|rdfs:label|StudyProduct_be8f763d-e2cf-38ad-b706-3f7ae2c239f9 imgt:Cancers_epithelial_ovarian|rdfs:label|Cancers_epithelial_ovarian imgt:StudyProduct_f2011b88-e166-3b82-a33b-c06ed4f1f95a|imgt:hasClinicalPhase|imgt:Phase_II imgt:Construct_297|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:mAb_732|imgt:inn_name|transferrin aldifitox imgt:CH2-CH3-FGF21|rdf:type|imgt:ChainLabels imgt:IgG1-kappa-%5BPROTEIN%5D2_1225|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa-[PROTEIN]2.png imgt:IgG1-kappa_719|http://semanticscience.org/resource/SIO_000291|imgt:influenza_A_virus_hemagglutinin_HA imgt:Product_5fdd43ec-f2fc-3091-8c32-f09459cb8152|imgt:isProducedBy|imgt:Roche_F_Hoffmann-La_Roche_Ltd imgt:IgG1-kappa_180|imgt:hasMolecularComponent|imgt:IG imgt:Construct_302|obo:BFO_0000051|imgt:Segment_302_1 imgt:Fab%27-G1-nd_139|http://semanticscience.org/resource/SIO_000291|imgt:NCA-90 imgt:StudyProduct_469a2965-c713-3c5d-9a91-b1a0403bb593|imgt:development_technology| VelocImmune® imgt:Construct_1272|imgt:isConstructOf|imgt:IgG1-kappa_1272 imgt:Product_0fadbe13-0b39-3d66-a629-2ef0fb22e31b|imgt:commun_name|ABY-035 imgt:CD40|imgt:isTargetOf|imgt:IgG4-kappa_563 imgt:mAb_1019|imgt:hasMabReceptor|imgt:IgG4-kappa-protein_1019 imgt:Segment_526_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:mAb_1290|rdf:type|imgt:INN imgt:11671|rdf:type|obo:NCIT_C25402 imgt:GlaxoSmithKline|imgt:produces|imgt:Product_e74c938c-d5ce-32f7-80c4-b52d9dfc9789 imgt:Construct_29|obo:BFO_0000051|imgt:Segment_29_1 imgt:StudyProduct_4adb7627-2f8a-3ff1-97fd-04fe49ec7aaf|imgt:hasClinicalPhase|imgt:Discontinued imgt:StudyProduct_3b49444b-27d5-3009-9948-320cd9518ba7|rdfs:label|StudyProduct_3b49444b-27d5-3009-9948-320cd9518ba7 imgt:Product_297a09a3-ed5b-3651-8ce5-22baa225b7cf|rdfs:label|Product_297a09a3-ed5b-3651-8ce5-22baa225b7cf imgt:StudyProduct_55a156ea-da4e-33ce-a9e6-9f0babfbbc74|imgt:hasClinicalPhase|imgt:Phase_II imgt:CH2|skos:definition|exon CH2 of IG heavy C-GENE in gDNA, or second C-DOMAIN of IG heavy chain in cDNA _:B2e055619a54183c3f6ebec29a341dd98|imgt:hasStatut|imgt:approval imgt:AOC3|rdfs:label|AOC3 imgt:Segment_633_1|obo:BFO_0000050|imgt:Construct_633 imgt:Segment_169_1|imgt:has_rank|1 imgt:ENZ-CARRIER_BIG_694|rdf:type|imgt:MAbReceptor imgt:StudyProduct_f905c71c-20c3-3fe9-88f2-445c0b34e3e5|rdfs:label|StudyProduct_f905c71c-20c3-3fe9-88f2-445c0b34e3e5 imgt:StudyProduct_79da9360-7ded-3b48-b96d-184138772585|rdfs:label|StudyProduct_79da9360-7ded-3b48-b96d-184138772585 imgt:GH1_(growth_hormone_1_somatotropin_GH_GH-N_GHN_hGH-N_pituitary_growth_hormone)-XTEN|rdf:type|imgt:ConstructLabels imgt:mAb_136|imgt:hasProduct|imgt:Product_eabf76ed-a75b-38a7-beee-34c4b6f691bb imgt:VH-VH%27-VH_trivalent|rdfs:label|VH - VH' - VH, trivalent imgt:TNF|imgt:isTargetOf|imgt:IgG4-kappa_30 obo:NCIT_C157279|rdfs:subClassOf|obo:NCIT_C1909 imgt:mAb_784|imgt:hasImgtStructureEntry|imgt:10754 _:Bedaf1fd61a4109c65e213f6449d5e8f8|imgt:isDecisionOf|imgt:StudyProduct_29562df2-37fe-38ae-a623-e694518eba7f imgt:StudyProduct_4abae086-95eb-3200-b72c-9fbed20f68af|imgt:hasClinicalIndication|imgt:Autoimmune_diseases imgt:IgG4-kappa_886|rdfs:label|IgG4-kappa_886 imgt:mAb_984|imgt:clinical_trials|10 studies found, 5 recruiting imgt:StudyProduct_4633b912-debb-31fd-875f-fe1e9822873b|imgt:hasClinicalPhase|imgt:Discontinued imgt:mAb_206|imgt:hasBibliographicReference|pubmed:7991583 imgt:StudyProduct_eb2001b5-f2f3-3b57-a83e-5363729c6bf5|rdfs:label|StudyProduct_eb2001b5-f2f3-3b57-a83e-5363729c6bf5 imgt:mAb_1109|rdfs:label|mAb_1109 imgt:mAb_472|imgt:inn_name|pembrolizumab imgt:Construct_1191|rdfs:label|Construct_1191 imgt:V-(VJ)-J-C-CLUSTER|rdf:type|imgt:ComposedClusterLabel _:B02c0079b832202ec4a2686413895f784|imgt:hasStatut|imgt:approval imgt:mAb_1159|imgt:inn_name|retlirafusp alfa imgt:J-GENE|skos:definition|gDNA of an IG or TR joining (J) gene, in germline configuration, that comprises J-REGION, with 5'UTR (including 5'J-RS) and 3'UTR imgt:Ig(G1-kappa_G1-lambda2)|rdfs:label|Ig(G1 - kappa_G1 - lambda2) obo:NCIT_C88600|rdf:type|owl:Class imgt:mAb_286|imgt:hasProduct|imgt:Product_16a5cdae-362b-3d27-a1d8-f8c7b78b4330 imgt:mAb_142|imgt:inn_name|tositumomab imgt:Construct_377|obo:BFO_0000051|imgt:Segment_377_2 imgt:Product_c23cf240-f365-3619-b7f6-936b4aae6390|imgt:isProducedBy|imgt:Genmab_A/S imgt:Construct_116|rdfs:label|Construct_116 imgt:mAb_1115|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=1115 imgt:|owl:imports|file:///home/gaoussou/eclipse-workspace/imgtkbcreator_sg20/data/ontology/ncit_2_imported.owl obo:NCIT_C80041|rdfs:subClassOf|obo:NCIT_C1909 imgt:mAb_1172|rdf:type|imgt:INN pubmed:1762576|rdfs:label|PMID_1762576 imgt:5ICY|rdf:type|obo:NCIT_C25402 imgt:StudyProduct_5103d28f-4657-32c4-8d25-5305c9f99bce|imgt:hasClinicalIndication|imgt:Asthma_severe_persistent imgt:Product_df8967e5-5089-3688-ab7d-c0aa071a918e|imgt:hasStudyProduct|imgt:StudyProduct_838b5be0-7266-3d65-bedc-26272c95fa9b imgt:Cancers_ovarian|imgt:isClinicalIndicationOf|imgt:StudyProduct_3d7a7c5d-f67d-3d22-acb3-8a9ceec296ee imgt:mAb_80|imgt:hasImgtStructureEntry|imgt:8380 imgt:mAb_246|rdf:type|imgt:INN imgt:Clone_240|imgt:clone_name|LM609 imgt:IgG1-lambda_946|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-lambda.png imgt:mAb_685|rdfs:label|mAb_685 imgt:StudyProduct_8c63dc3d-4414-3596-928d-549fc6f3f5b1|imgt:hasClinicalPhase|imgt:Phase_M imgt:StudyProduct_4ad05f7d-2ddc-3e0f-8268-a11c509395ed|rdfs:label|StudyProduct_4ad05f7d-2ddc-3e0f-8268-a11c509395ed imgt:Product_8e4f31af-8bb6-303e-b57e-d15ba5bd4075|imgt:hasStudyProduct|imgt:StudyProduct_06350178-995f-30ee-8f5b-7f9fd75bebd5 imgt:StudyProduct_702dbc3d-39c7-30e1-b3b4-1256085457af|rdfs:label|StudyProduct_702dbc3d-39c7-30e1-b3b4-1256085457af imgt:Product_46ba9f2a-6976-370b-8353-203ec4474217|rdfs:label|Product_46ba9f2a-6976-370b-8353-203ec4474217 imgt:Construct_174|imgt:isConstructOf|imgt:IgG4-kappa_174 imgt:TRION_Pharma|rdf:type|obo:NCIT_C54131 _:B8b8fd2d1f14c2fc37f1c2b20db144476|imgt:hasDesignation|imgt:Orphan_drug _:B4aa5a7cd2ff5917ef2b756160e01e765|dc:date|2017-06-08 imgt:mAb_152|imgt:hasProduct|imgt:Product_bca639d9-3ea1-3a92-b97f-0d34a9d52fd8 imgt:Segment_521_2|imgt:has_rank|2 imgt:C-gene|rdfs:label|C-gene imgt:Segment_1268_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:StudyProduct_7027cb45-d588-3eb7-b1c2-d35ec6045bee|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:StudyProduct_0d159da4-02de-3768-90bb-c071c26d5c1a|rdfs:label|StudyProduct_0d159da4-02de-3768-90bb-c071c26d5c1a imgt:Cancers_gastric|imgt:isClinicalIndicationOf|imgt:StudyProduct_fafaa338-3a65-3f96-9bf7-6290eda1212b imgt:IgG_Lambda|rdf:type|imgt:ReceptorType imgt:mAb_180|imgt:imgt_note| Medarex was acquired by Bristol Myers Squibb in 2009. Medarex’s UltiMAb Human Antibody Development System®, uses transgenic mice, specifically Medarex’s HuMAb-Mouse®, Kirin Brewing Co., Ltd’s TC Mouse and the KM-Mouse, a hybrid of the former two mice. Phase I/II in combination with varlilumab for metastatic melanoma. imgt:IgG2a-kappa-G2b-lambda_219|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG2a-kappa-G2b-lambda.png imgt:Product_d30bc7a3-4607-3c49-9f28-691cff219e66|imgt:isProductOf|imgt:mAb_494 imgt:mAb_306|rdf:type|obo:NCIT_C1909 imgt:Product_5a490e25-bdeb-3fc5-b45d-f7095463e64a|rdfs:label|Product_5a490e25-bdeb-3fc5-b45d-f7095463e64a _:Bf9b3b262bd59784aaa0d24e9dbf55b2f|imgt:isDecisionOf|imgt:StudyProduct_f076d291-a18a-317a-9d91-2653f3cde677 imgt:Product_8a6a655e-c029-3db0-abba-ab5a2dc29089|imgt:commun_name|MDX-CTLA-4 imgt:1V-LIKE_1V-LIKE|rdf:type|imgt:RPILabel imgt:StudyProduct_1ab8d4c3-d225-3383-97de-5f1bb986f6f1|imgt:hasClinicalIndication|imgt:Psoriasis_pediatric imgt:CFD|obo:RO_0002162|imgt:Homsap imgt:mAb_275|imgt:hasMabReceptor|imgt:PROTEIN_2ANDHALFREPEATS-PEG_275 imgt:Astellas_Pharma_Inc|rdf:type|obo:NCIT_C54131 imgt:IgG4-kappa_642|rdf:type|imgt:MAbReceptor imgt:Product_92aaaa11-a012-35e5-91ee-9df570fa89a7|imgt:comercial_name|STELARA® imgt:IgG1-kappa_400|imgt:hasConstruct|imgt:Construct_400 imgt:mAb_188|imgt:imgt_note| Morphosys HuCAL® (Human combinatorial Antibody library) phage display library _:B04db4c056d5048ca1f4547c78b9a69f6|imgt:isDecidedBy|imgt:EMA imgt:IgA_Lambda|imgt:isDefinedBy|imgt:IG-Light-Lambda-IGL imgt:Product_11b4ca7d-b70a-3a66-b4e3-f8d1ba3e7e07|imgt:commun_name|centoxin imgt:StudyProduct_b70513a8-0baa-3a75-ab83-97c07e45443a|imgt:application_type|Therapeutic imgt:Product_6921438e-7c6b-3e42-bd7f-0e3bc47d6848|imgt:hasStudyProduct|imgt:StudyProduct_8d02060f-aff2-3c4b-8021-43053f573c06 imgt:MAbReceptor_141|imgt:hasConstruct|imgt:Construct_141 imgt:StudyProduct_57964c70-1d0c-31a0-ae68-ce18c2653a70|rdfs:label|StudyProduct_57964c70-1d0c-31a0-ae68-ce18c2653a70 imgt:mAb_29|imgt:hasProduct|imgt:Product_73c8ec8f-480f-3f67-8a38-326c93df880a imgt:StudyProduct_85ff6d84-e374-3eee-ba39-81d6e0189482|imgt:hasClinicalPhase|imgt:Phase_I 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imgt:mAb_252|imgt:hasProduct|imgt:Product_dafd1d43-d4e4-3d41-aea8-181641c8acbd imgt:mAb_623|imgt:imgt_note| The 166 amino acid sequence was derived by scanning the sequences of several natural interferon alpha subtypes and assigning the most frequently observed amino acid in each corresponding position. Four additional amino acid changes were made to facilitate the molecular construction, and a corresponding synthetic DNA sequence was constructed using chemical synthesis methodology. Interferon alfacon-1 differs from interferon alfa-2b at 19/166 amino acids (88% homology) and with interferon alfa-2a at 18/166 amino acids (88% homology). Comparison with interferon-beta shows identity at over 30% of the amino acid positions. INFERGEN http://www.fda.gov/downloads/Drugs/DevelopmentApprovalProcess/HowDrugsareDevelopedandApproved/ApprovalApplications/TherapeuticBiologicApplications/ucm093413.pdf. EMEA approval for INFERGEN in Europe in 1999 to Yamanouchi Europe BV, then to Astellas Pharma Europe B.V. (following the formation of Astellas Pharma Inc. on 1 April 2005 from the merger of Yamanouchi Pharmaceutical Co., Ltd. and Fujisawa Pharmaceutical Co., Ltd.). On 6 April 2006, the European Commission was notified by Astellas Pharma Europe B.V. of its decision to voluntarily withdraw the marketing authorization for INFERGEN for commercial reasons. On May 2006 the European Commission issued a decision to withdraw the marketing authorisation for INFERGEN. imgt:PROTEIN_1DOMAIN_641|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/PROTEIN_1DOMAIN.png imgt:Product_9e247767-e0b8-38a4-90d4-325a384a774a|imgt:isProductOf|imgt:mAb_716 imgt:mAb_472|imgt:clinical_trials|1330 studies found, 329 recruiting imgt:StudyProduct_49da4a97-7e26-3138-8135-9bd4fc348fd1|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_eba83d89-9fc8-31a7-9337-0a034a6a47cd|imgt:isStudyProductOf|imgt:Product_db3d4ac6-821a-3423-ba1d-61b8ad6cf363 imgt:mAb_41|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=41 imgt:StudyProduct_40fc8ece-1fab-3e40-9011-12e54af47f13|imgt:hasDecision|_:Bc0b454e5c769df86ac5b1234b1c5c3c2 imgt:Segment_388_1|imgt:hasImgtLabel|imgt:ACVRL1 imgt:Product_b9a738f9-5b22-38f9-848f-e3ea2ee2b97d|imgt:hasStudyProduct|imgt:StudyProduct_2885244f-5d5a-36a6-b367-fb9982d41711 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imgt:StudyProduct_c9b26fdc-0c61-338f-8e80-c446ecc312fe|rdfs:label|StudyProduct_c9b26fdc-0c61-338f-8e80-c446ecc312fe imgt:StudyProduct_ee00fd15-4396-3146-9aa4-d1dc63eeb3c2|rdf:type|obo:NCIT_C174271 imgt:Product_75f31599-7147-3250-906f-28fba39a311c|imgt:hasStudyProduct|imgt:StudyProduct_b60cc623-8ec0-33f7-9dde-f372c63581ac imgt:Product_b5705ddd-9295-3d44-901f-fdef1f9e9ae6|rdfs:label|Product_b5705ddd-9295-3d44-901f-fdef1f9e9ae6 imgt:StudyProduct_350def7c-fdaa-31bd-8120-ac5abe9c7ff2|rdfs:label|StudyProduct_350def7c-fdaa-31bd-8120-ac5abe9c7ff2 imgt:Product_dcf2f323-352b-3484-abe2-f1687814dc60|imgt:hasStudyProduct|imgt:StudyProduct_92fa5e3e-ae62-31a2-939f-aab0c6095c4b _:Bf2691192ec8aa9f02af5e8362d68e51f|dc:date|2017-08-03 imgt:Product_d9c0e462-7a45-30ba-bdd2-48dcf77e60dc|imgt:commun_name|MEDI4736 imgt:StudyProduct_e87ab206-c83e-3df7-887b-3c92776d9448|imgt:application_type|Therapeutic imgt:StudyProduct_fc46d94f-5cec-3326-b718-1c5593253bab|imgt:hasDecision|_:B18581847083d09f8a1f0205124c681af 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USA) in January 2013. imgt:mAb_958|imgt:hasImgtStructureEntry|imgt:11146 imgt:StudyProduct_b491f4a1-8ff3-3630-af35-11b68c0fb731|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_c081fa56-a921-36df-afc7-4fda57fffc19|rdfs:label|StudyProduct_c081fa56-a921-36df-afc7-4fda57fffc19 imgt:9368|imgt:isImgtStructureEntryOf|imgt:mAb_368 imgt:StudyProduct_1c304e20-ebb6-3cc3-9d92-318c71239249|imgt:isStudyProductOf|imgt:Product_58163f7c-6428-37b2-b8ea-0d3a1c1187a0 imgt:StudyProduct_3a112820-24e5-38b4-b74d-fed953863cdc|imgt:hasClinicalPhase|imgt:Phase_I imgt:Product_f8dfc2ee-a731-383a-994f-8369df62ef25|imgt:hasStudyProduct|imgt:StudyProduct_e6f8d005-98be-31e4-9c9f-cee3e576b051 imgt:IgG1-kappa-1lys-drug_936|http://semanticscience.org/resource/SIO_000291|imgt:CD33 imgt:Mycobacterium_tuberculosis_variant_bovis_chaperonin_2_(HSP65_from_Mycobacterium_bovis)-Alphapapillomavirus_9_E7_HPV16|rdf:type|imgt:ConstructLabels 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imgt:StudyProduct_ea32661f-d823-3db2-a1de-f9a6e627ebd0|imgt:isStudyProductOf|imgt:Product_98230829-4ca8-374b-b462-6c690e79d2e5 pubmed:7772562|dc:contributor|Buttle M. imgt:Construct_542|rdfs:label|Construct_542 imgt:F9|imgt:isTargetOf|imgt:IgG4-kappa_564 imgt:StudyProduct_52c977a0-d7e8-34e4-94d4-a8442f8eb205|imgt:application_type|Therapeutic imgt:Product_f21edd5d-c119-3b27-a5be-d51a4f2ba15a|imgt:commun_name|F520 imgt:Product_2715c586-cf44-3ed8-a87b-0d76d5b9bd0c|imgt:isProducedBy|imgt:Pfizer imgt:IG-Light-Lambda-7-IGLC7|imgt:hasChainTypeLevel|imgt:IG-Light-Lambda-IGL imgt:Construct_289|obo:BFO_0000051|imgt:Segment_289_1 imgt:Construct_1211|obo:BFO_0000051|imgt:Segment_1211_1 imgt:EPHA3|skos:definition|EPHA3 (ephrin receptor A3, EPH receptor A3, ephrin type-A receptor 3, tyrosine protein kinase TYR04, tyrosine-protein kinase receptor REK4, ETK, ETK1, HEK, HEK4) pubmed:9140729|imgt:isBibliographicReferenceOf|imgt:mAb_91 imgt:Cancers_non-small_cell_lung_(NSCLC)_metastatic|imgt:isClinicalIndicationOf|imgt:StudyProduct_c2bc9b3a-a15e-376f-bda5-f87089b3f54b imgt:IgG1-kappa_740|imgt:hasConstruct|imgt:Construct_740 imgt:Clone_1288|rdfs:label|Clone_1288 imgt:IgG1-kappa_1122|rdfs:label|IgG1-kappa_1122 imgt:StudyProduct_7e33aa3f-6f4e-3b97-9866-e6b5181831a3|imgt:hasClinicalIndication|imgt:Scleroderma imgt:mAb_1003|imgt:hasImgtStructureEntry|imgt:11258 imgt:StudyProduct_0f7eb5d2-25f4-3ec3-903d-96073744e63d|imgt:hasClinicalPhase|imgt:Phase_III imgt:(scFv-heavy-kappa)-(scFv-kappa-heavy)|rdfs:label|(scFv - heavy - kappa) - (scFv - kappa - heavy) _:B2c99553dcff1c2ba4133a517e07f1451|dc:date|1996-08-20 imgt:IgG1-kappa-6cys-drug_558|imgt:hasMolecularComponent|imgt:IG _:Bbd3f7b033bc730c9d2d35615de62b6aa|rdf:type|obo:NCIT_C53285 imgt:chaperonin_2|rdfs:label|chaperonin 2 imgt:MedImmune|imgt:produces|imgt:Product_6c67e17c-42f8-38c2-9f6f-6580bc4cf2e7 pubmed:15664918|dc:date|2005 imgt:Segment_1103_1|rdfs:label|Segment_1103_1 imgt:mAb_164|imgt:hasProduct|imgt:Product_2a3ef47f-5316-35ed-88d8-4e4553dda6a6 imgt:StudyProduct_55e7541c-3eab-3d0c-9193-6cda10fdcba2|imgt:hasClinicalIndication|imgt:Solid_tumors imgt:StudyProduct_575860fa-e243-3848-aa0c-4ef1c3997fbc|imgt:isStudyProductOf|imgt:Product_c590bcda-c499-3148-b8e2-0bec3917880f imgt:StudyProduct_a17be910-448c-39cd-9135-1e69cc88ffe0|imgt:isStudyProductOf|imgt:Product_5b1165a9-49bf-32ac-9616-2dd4a613180e imgt:Construct_1079|rdf:type|imgt:Construct imgt:Segment_1152_1|rdf:type|imgt:Segment imgt:StudyProduct_54b5ec2b-b076-30c6-b77b-957876db16ce|rdfs:label|StudyProduct_54b5ec2b-b076-30c6-b77b-957876db16ce imgt:Segment_1036_1|obo:BFO_0000050|imgt:Construct_1036 imgt:TR-GAMMA-3|imgt:describes|imgt:TR-Gamma-3-TRGC3 imgt:Asthma|imgt:isClinicalIndicationOf|imgt:StudyProduct_5238c8b8-e8b4-32d3-a68f-157633d0b23b imgt:IgG2-G4-kappa_674|imgt:hasConstruct|imgt:Construct_674 imgt:StudyProduct_0fe403ef-7b3a-3686-8283-a4cb356a3e53|imgt:hasClinicalPhase|imgt:Phase_II imgt:StudyProduct_629d4aff-1483-3f88-bf03-a1d3ebc3a37e|imgt:hasDecision|_:Bc4e2ab0979eb61d3b554c535b5239674 imgt:mAb_1292|imgt:hasProduct|imgt:Product_a92db19e-acaf-3b18-8363-ab3546fcfaa5 imgt:StudyProduct_a1504ba6-644f-3bb1-b6d8-21de11e72fd2|imgt:hasClinicalIndication|imgt:Solid_tumors imgt:IgG4-kappa-lambda_973|imgt:isMabReceptorOf|imgt:mAb_973 imgt:scFv-h-CH2-CH3_1032|rdfs:comment|scFv-h-CH2-CH3 _:B4612f4f8cdac8b7b0835398ce120bc55|dc:date|2020-11-30 imgt:StudyProduct_f3d1c1a5-f965-3e64-9447-58a48d2fee54|imgt:isStudyProductOf|imgt:Product_130a13fd-abe7-3be7-a4a1-b2d3860d8fac imgt:mAb_862|imgt:hasImgtStructureEntry|imgt:10830 imgt:Clone_1240|imgt:isOriginCloneOf|imgt:mAb_1240 imgt:Segment_216_1|rdfs:label|Segment_216_1 imgt:Segment_1164_2|imgt:hasImgtLabel|imgt:IGHG1 imgt:%5BPEPTIDE%5D2-FC_392|imgt:isMabReceptorOf|imgt:mAb_392 imgt:StudyProduct_8f55d686-8290-361c-8038-b10f381fb217|imgt:hasClinicalIndication|imgt:Cancers_non-small_cell_lung_(NSCLC) imgt:mAb_1068|imgt:inn_recommended_list|85 (2021) imgt:StudyProduct_e6f8d005-98be-31e4-9c9f-cee3e576b051|imgt:application_type|Therapeutic imgt:mAb_158|imgt:hasMabReceptor|imgt:IgG1-kappa_158 imgt:Product_6b3a8790-0da7-338c-985a-3f5c5832b3bb|imgt:commun_name|17.1.41 imgt:mAb_854|imgt:hasMabReceptor|imgt:IgG4-kappa_854 imgt:mAb_334|imgt:inn_recommended_list|64 (2010) imgt:IgG1-kappa-4lys-drug_52|imgt:via_a| thiopentanoate linker (or reducible SPP (N-succinimidyl 4-(2-pyridyldithio)) linker) imgt:mAb_335|imgt:hasProduct|imgt:Product_52893bc3-54bd-39c4-9455-4c65e11f1653 imgt:MSLN|rdf:type|obo:NCIT_C25702 imgt:StudyProduct_4b5bfd63-8cd3-3214-b48a-f4c898c46e26|imgt:application_type|Therapeutic imgt:FUSION-%5BCTLA4%5D2-FC-GAMMA-1|skos:definition|Fusion protein for immune application (FPIA) comprising CTLA4 fused with immunoglobulin G1 FC fragment imgt:StudyProduct_9540c804-8715-398d-a80d-2df6b94b5756|imgt:isStudyProductOf|imgt:Product_13575050-2ff0-3cea-9e48-bb9edfec537d pubmed:16697465|dc:title|A human monoclonal IgG1 potently neutralizing the pro-inflammatory cytokine GM-CSF. imgt:mAb_130|imgt:inn_number|7934 imgt:truncated|dc:identifier|imgt_000302 imgt:StudyProduct_c604db8e-c214-3403-8739-e794fbdea73b|rdfs:label|StudyProduct_c604db8e-c214-3403-8739-e794fbdea73b imgt:IgG1-kappa_978|obo:RO_0002162|imgt:Hum imgt:Clone_420|imgt:clone_name|ICR62 imgt:V-J-GENE|imgt:imgt_link|http://www.imgt.org/IMGTScientificChart/SequenceDescription/displayimage.php?id=20 imgt:StudyProduct_0bfe55ef-4480-30eb-b211-3dc2d511fa9e|imgt:isStudyProductOf|imgt:Product_75f31599-7147-3250-906f-28fba39a311c pubmed:20035694|imgt:isBibliographicReferenceOf|imgt:mAb_372 imgt:Respiratory_Syncytial_Virus_(RSV)_infection|imgt:isClinicalIndicationOf|imgt:StudyProduct_870cb216-92e0-3b76-ae22-d76634800ed2 imgt:StudyProduct_9578ebf7-143d-3548-9867-706dd07f2f9a|imgt:isStudyProductOf|imgt:Product_1ee293d6-44ea-3bcb-84c3-b34b51c264d4 imgt:Neuromyelitis_optica_(NMO)|imgt:isClinicalIndicationOf|imgt:StudyProduct_2b5823b9-ed23-3d5a-b882-138c8f1a4919 imgt:mAb_954|imgt:inn_proposed_list|121 (2019) _:B52ee01255ddddb4ca9332217c3332c4e|rdf:type|obo:NCIT_C53285 imgt:%5BGCG_analog-PEG_linker%5D1-IGHG4_Fc_(Fragment_constant)|imgt:construction_detail|Conjugate - [GCG analog - PEG linker]1 - IGHG4 Fc (Fragment constant) imgt:StudyProduct_ec9edeaa-3a0d-3d75-9378-824aa1457d40|imgt:hasClinicalIndication|imgt:Human_cytomegalovirus_(HCMV) imgt:mAb_307|rdf:type|obo:NCIT_C166480 imgt:Product_dc2a0795-349d-373b-be05-d16cf2186843|imgt:hasStudyProduct|imgt:StudyProduct_38906f87-bda5-34ff-be13-2ad09d9a87b9 imgt:IgG1-kappa_1146|imgt:isMabReceptorOf|imgt:mAb_1146 imgt:Product_7206ce92-2c30-3a53-96b4-d2f0bd2f1dd3|rdf:type|obo:NCIT_C51980 imgt:StudyProduct_db0139c4-7901-30e0-953e-7b4d31e496e8|rdf:type|obo:NCIT_C174271 imgt:LukGH|rdf:type|obo:NCIT_C25702 imgt:StudyProduct_07a5f952-0251-3d02-a564-4c63a25f800e|rdf:type|obo:NCIT_C174271 imgt:TR-GAMMA-2|rdfs:label|TR-GAMMA-2 imgt:StudyProduct_a7147b0f-c37e-38c3-9789-050b51921426|rdfs:label|StudyProduct_a7147b0f-c37e-38c3-9789-050b51921426 imgt:IgG4-kappa_155|http://semanticscience.org/resource/SIO_000291|imgt:CD14 imgt:CD3E|imgt:isTargetOf|imgt:VH-VL-VH%27-VL%27_679 imgt:StudyProduct_32ca3e79-d321-3d7a-85a7-31eebcc38bf8|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_e7ccbaca-89b8-33e8-962f-c19741fda74e|rdfs:label|StudyProduct_e7ccbaca-89b8-33e8-962f-c19741fda74e obo:NCIT_C61070|rdfs:subClassOf|obo:NCIT_C1909 imgt:StudyProduct_0ae77efd-e7bd-35b3-812d-dd2e43ab1931|imgt:isStudyProductOf|imgt:Product_e9e52bcc-24ec-39dc-8de4-b4ba591c6845 pubmed:2480605|dc:title|CD4-Pseudomonas exotoxin hybrid protein blocks the spread of human immunodeficiency virus infection in vitro and is active against cells expressing the envelope glycoproteins from diverse primate immunodeficiency retroviruses. imgt:Optic_neuritis|imgt:clinical_domain|Inflammation imgt:StudyProduct_212e3329-36d0-3a95-b393-3340484d9697|rdfs:label|StudyProduct_212e3329-36d0-3a95-b393-3340484d9697 _:B15dd1ef0e61ebd89ccb3b8b9952ec65c|imgt:hasStatut|imgt:approval imgt:Product_40d4733b-8629-353c-8086-ad4391678aa1|imgt:hasStudyProduct|imgt:StudyProduct_6e168288-491c-3132-b812-777125d4af08 imgt:Product_df7aa59a-c953-3d7c-aae2-38c9ce0095f4|imgt:isProducedBy|imgt:Eli_Lilly pubmed:10597336|rdf:type|bibo:Article imgt:Age-related_macular_degeneration_(AMD)|imgt:isClinicalIndicationOf|imgt:StudyProduct_2a06774d-06b0-3958-b58b-28d3b152220a imgt:mAb_711|imgt:inn_proposed_list|10 (1960) imgt:StudyProduct_a6408207-9703-365a-badb-e1f481cce777|rdfs:label|StudyProduct_a6408207-9703-365a-badb-e1f481cce777 imgt:Segment_18_1|imgt:hasImgtLabel|imgt:IgG1-nd imgt:Product_39c70977-6744-3fb3-ac1f-33471e65a66e|rdf:type|obo:NCIT_C51980 imgt:mAb_847|imgt:inn_name|dilpacimab imgt:Product_20681962-782d-323a-88be-94240e1b0ace|imgt:commun_name|YBL 006 imgt:mAb_541|imgt:hasImgtStructureEntry|imgt:10078 imgt:Thrombocytopenia|imgt:isClinicalIndicationOf|imgt:StudyProduct_5d73388e-1ce1-3b49-baa5-c24c65fbfd2d imgt:Neuroblastoma|rdfs:label|Neuroblastoma imgt:Pemphigus_vulgaris_(PV)|imgt:isClinicalIndicationOf|imgt:StudyProduct_a2a081d5-59eb-3fa4-a13b-47f1cd92f227 imgt:StudyProduct_6ee58395-ba07-36f4-abe7-f7b57669944c|rdf:type|obo:NCIT_C174271 imgt:Product_f05098e0-166e-3680-9f12-888766e2989e|imgt:commun_name|PRV-015 imgt:Construct_360|imgt:isConstructOf|imgt:IgG1-kappa_360 imgt:Segment_852_1|rdf:type|imgt:Segment imgt:StudyProduct_38094478-025b-385e-b251-914f5490d566|imgt:isStudyProductOf|imgt:Product_75a2ea16-7c01-33b5-99ec-50f47304f68d imgt:Waldenstrom's_macroglobulinemia|rdfs:label|Waldenstrom's_macroglobulinemia imgt:X-linked_hypohidrotic_ectodermal_dysplasia_(XLHED)|rdf:type|obo:NCIT_C185637 imgt:StudyProduct_f6a4d3e0-3533-34cd-b5a3-e402980b80d9|imgt:hasClinicalPhase|imgt:Phase_M imgt:StudyProduct_9a6a57da-3438-3eab-888f-fcecf0568e8a|imgt:development_technology| No N-glycosylation sites CH2 N84.4A Antibody phage display library imgt:StudyProduct_f4807e52-f39a-3b92-ad82-f3540c8f3fcc|imgt:application_type|Therapeutic imgt:StudyProduct_9a250394-ad13-3925-82cd-03f0b37210e6|rdf:type|obo:NCIT_C174271 imgt:Segment_410_1|obo:BFO_0000050|imgt:Construct_410 imgt:11391|rdf:type|obo:NCIT_C25402 imgt:Segment_635_1|imgt:segment_detail|22-184 (P40225-1) obo:NCIT_C175736|rdfs:subClassOf|obo:NCIT_C1909 imgt:mAb_675|imgt:hasProduct|imgt:Product_dedf2cda-9a79-3099-b41b-d4cfcb51cc21 imgt:Product_4d3d1c57-c33d-3fb9-a04f-cdb7a0a344c2|imgt:hasStudyProduct|imgt:StudyProduct_87df2003-d770-3cc3-88b8-b055ef490e3c imgt:StudyProduct_06f7f86b-9caf-3c74-88da-482672c16dbf|imgt:hasExpressionSystem|imgt:_Sp2/0_mouse_hybridoma_cells imgt:Construct_1297|obo:BFO_0000051|imgt:Segment_1297_1 imgt:Product_88568e72-96c0-305a-a89f-24f789162533|rdfs:label|Product_88568e72-96c0-305a-a89f-24f789162533 imgt:StudyProduct_2bd33fa7-b307-3893-953b-cf6f2d404e13|rdf:type|obo:NCIT_C174271 imgt:IgG4-kappa_1198|imgt:isMabReceptorOf|imgt:mAb_1198 imgt:StudyProduct_f95e7e1c-4453-3bfe-835c-1245dfb30b90|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:Segment_120_1|obo:BFO_0000050|imgt:Construct_120 imgt:mAb_249|rdf:type|imgt:INN imgt:IgG1-lambda_183|imgt:hasMolecularComponent|imgt:IG obo:NCIT_C103274|rdfs:subClassOf|obo:NCIT_C1909 imgt:Product_3fbfe977-f5f9-381b-94d0-489e229f2eaf|imgt:isProductOf|imgt:mAb_708 imgt:FGFR4|imgt:isTargetOf|imgt:PROTEIN_1DOMAIN_899 imgt:StudyProduct_0a8a5bf8-b179-3f11-aca7-644878e57936|imgt:hasExpressionSystem|imgt:_CHOK1SV_(expresses_glutamine_synthetase_(GS)_endogenously)_cells imgt:StudyProduct_a2a3e31e-0940-38d5-86a0-dbdc0138f29c|imgt:isStudyProductOf|imgt:Product_2a27388e-d392-3da3-965b-cd111e3e9a5a imgt:Product_2de293bd-1023-3307-9fbd-5af2cf15c7e6|imgt:commun_name|huC242-DM1 imgt:StudyProduct_f5b5f2b6-8fd7-38b9-938b-4f838a392b75|rdf:type|obo:NCIT_C174271 imgt:IG-Heavy-Alpha-1-IGHA1|imgt:defines|imgt:IgA1_Lambda imgt:mAb_466|rdfs:label|mAb_466 imgt:mAb_1189|imgt:inn_number|11771 imgt:H-gamma1_L-kappa-scFv(heavy-kappa)_1138|http://semanticscience.org/resource/SIO_000291|imgt:CD3E imgt:Clone_379|rdf:type|obo:NCIT_C37925 imgt:mAb_696|imgt:hasMabReceptor|imgt:HOR-CTP_696 imgt:Segment_1204_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:IgG1-kappa_322|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:Anti-platelet_prevention_of_blood_clots_in_the_setting_of_high_risk_percutaneous_transluminal_coronary_angioplasty|rdfs:label|Anti-platelet_prevention_of_blood_clots_in_the_setting_of_high_risk_percutaneous_transluminal_coronary_angioplasty imgt:StudyProduct_21694c6c-877e-3426-8dc2-a88c164223db|rdfs:label|StudyProduct_21694c6c-877e-3426-8dc2-a88c164223db imgt:Systemic_lupus_erythematosus_(SLE)|imgt:isClinicalIndicationOf|imgt:StudyProduct_0b9b180b-365a-3d5d-9ff6-ab0449929fca imgt:Construct_416|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:mAb_156|imgt:hasBiosimilar|imgt:flixabi® imgt:StudyProduct_1df780ca-8602-328d-9d48-e259fef5c601|imgt:isStudyProductOf|imgt:Product_9186186a-7147-3fe7-bbf9-599dbe1368ab imgt:Product_7a590139-a8dc-33f6-b868-ffaa80fc628a|imgt:hasStudyProduct|imgt:StudyProduct_2ceb9ece-6988-33ea-aecd-5333db1f0dd9 imgt:StudyProduct_f918e2b4-7231-3162-99ee-af94a0a5b68b|rdfs:label|StudyProduct_f918e2b4-7231-3162-99ee-af94a0a5b68b imgt:Construct_637|rdf:type|imgt:Construct imgt:Construct_1058|imgt:hasImgtLabel|imgt:(scFv-heavy-kappa)-(scFv-heavy-lambda)-scFc imgt:mAb_264|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=264 _:B293e5816732bf2c177873fa27f4a26b1|imgt:hasDesignation|imgt:Orphan_drug imgt:Clone_570|rdfs:label|Clone_570 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imgt:Product_5eb41d03-904f-31e2-99cf-e8e07792e97b|rdf:type|obo:NCIT_C51980 imgt:Frontotemporal_Dementia|rdf:type|obo:NCIT_C185637 obo:SO_0000458|rdf:type|owl:Class imgt:Product_262ab471-0054-380f-bcca-d0e91b8d0a82|imgt:commun_name|HA22 imgt:mAb_819|imgt:inn_proposed_list|118 (2017) imgt:StudyProduct_036cdd39-9d78-3853-b645-e48ae3d4b24e|imgt:hasClinicalIndication|imgt:Lymphoproliferative_disease imgt:MRC_Technology|imgt:produces|imgt:Product_14bc3b7e-30da-3723-af19-76b738f8473b imgt:MISC_RECOMB|rdfs:label|MISC_RECOMB pubmed:8798431|dc:contributor|Glaser SM imgt:StudyProduct_9a1ace4b-c686-3cab-bf14-c4bc22f32a84|imgt:hasClinicalIndication|imgt:Carcinoma_bladder_cancer_advanced_or_metastatic_urothelial_cancers imgt:StudyProduct_a681b105-c7cf-39b6-91cd-a4a40c9f8e01|imgt:hasClinicalPhase|imgt:Preclinical imgt:Construct_28|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:mAb_254|imgt:imgt_note| Murine KS1/4 antibody: Varki NM et al. Cancer Res 44: 681-687 (1984) PMID: 6362852 Two molar equivalents of IL2 per mole of fusion protein: Xian R. et al. Cancer res 57: 4948-4955 (1997) PMID: 9354462 Expression in NS0: Xian R. et al. Cancer res 57: 4948-4955 (1997) PMID: 9354462 imgt:Segment_1131_1|imgt:has_rank|1 imgt:Fibronectin-2Label|skos:definition|Fibronectin domains F1 very similar to a V-DOMAIN with big insertion imgt:H|skos:definition|hinge exon of IG heavy C-GENE-UNIT (if only one) imgt:Segment_432_1|rdf:type|imgt:Segment imgt:IL12A|imgt:isTargetOf|imgt:MAbReceptor_181 _:B121bb90384765e14966dd4a8d37f8e94|imgt:isDecisionOf|imgt:StudyProduct_d141e5ff-8372-358a-8d88-fcc86d2244e0 imgt:Product_5c6f069e-5b7f-3b5e-8bc2-2580fdc050f8|imgt:isProductOf|imgt:mAb_166 imgt:mAb_172|imgt:clinical_trials|144 studies found, 51 recruiting imgt:J-gene|protege:protege#subclassesDisjoint|true imgt:StudyProduct_9781db57-fbca-397e-a7b8-253e716a7085|imgt:isStudyProductOf|imgt:Product_36cb4986-4d03-31c7-b2d0-954c198844be imgt:mAb_1133|imgt:hasProduct|imgt:Product_6a75c3c7-fd9d-3d13-ba55-34265317c29e imgt:Product_dd6c2b80-fda7-3c79-ad6d-2f201bcff085|imgt:commun_name|HuIFN-alpha-Le obo:NCIT_C166489|rdfs:subClassOf|obo:NCIT_C1909 imgt:StudyProduct_a2e8001d-fbf0-317c-b733-f348a8128ed2|imgt:hasClinicalIndication|imgt:Acute_myeloid_leukemia_(AML) imgt:G|rdf:type|imgt:ConfigurationType imgt:StudyProduct_fe408002-8117-360b-b6cd-b2e7eb7acea5|imgt:development_technology| MorphoSys's HuCAL® phage library imgt:IgG4-kappa_1121|imgt:hasMolecularComponent|imgt:IG obo:NCIT_C87763|rdf:type|owl:Class imgt:Cervical_dysplasia_vaccine|imgt:clinical_domain|Immunology imgt:mAb_667|imgt:inn_recommended_list|77 (2017) imgt:Product_251ce72b-d58e-3b17-a72c-6fc5928b0a8a|imgt:isProducedBy|imgt:PDL_(Protein_Design_Labs)_BioPharma imgt:StudyProduct_0ebea443-410a-3389-80d3-a2436982b339|imgt:hasClinicalIndication|imgt:Non-Hodgkin's_lymphoma_(NHL) imgt:Segment_1099_1|rdf:type|imgt:Segment imgt:Construct_320|imgt:hasImgtLabel|imgt:Fab-nd-nd imgt:Segment_413_2|imgt:has_rank|2 imgt:StudyProduct_e8e2b21e-7367-3a50-be7e-79d715917a10|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_e431bdd5-d4bb-3422-a165-dec80514e81c|imgt:application_type|Therapeutic imgt:FC-MU|rdfs:label|FC-MU imgt:StudyProduct_84a42155-6dd6-3495-a524-9129094cea33|rdfs:label|StudyProduct_84a42155-6dd6-3495-a524-9129094cea33 imgt:mAb_771|imgt:hasMabReceptor|imgt:IgG1-kappa_771 imgt:IgG4-kappa_1037|rdf:type|imgt:MAbReceptor imgt:Fab-G1-kappa_901|imgt:hasConstruct|imgt:Construct_901 imgt:Segment_52_1|imgt:has_rank|1 imgt:IL2RA|rdfs:label|IL2RA imgt:mAb_334|imgt:hasProduct|imgt:Product_a7783cec-9ac8-35f9-9629-3982e07c2ba0 imgt:IgG2b-kappa_1008|imgt:hasConstruct|imgt:Construct_1008 imgt:CR1_(Pr42-101)|skos:definition|Complement receptor type 1 imgt:StudyProduct_8162d513-eb16-3f06-a0e7-62382a7339e1|imgt:hasClinicalIndication|imgt:Non-Hodgkin's_lymphoma_(NHL) imgt:Product_7e372f5e-216d-3aa4-ad79-792648eecc36|imgt:hasStudyProduct|imgt:StudyProduct_ccb638da-fed8-33da-b299-b9b1b7928a81 imgt:StudyProduct_91fbf5b0-b23e-3257-ac57-ab48ca2802f6|imgt:isStudyProductOf|imgt:Product_f5e55c8d-239e-36ce-b0ca-d43a9d2f3f03 imgt:IgG1-nd_443|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-nd.png imgt:IgG4-kappa_1187|http://semanticscience.org/resource/SIO_000291|imgt:DKK1 imgt:StudyProduct_4778a46d-c73d-3a03-9a1f-5b7d0dabf9c3|imgt:hasClinicalPhase|imgt:Phase_M imgt:StudyProduct_75dc4e56-f274-3fc3-8e16-9ebe8ace02b2|rdf:type|obo:NCIT_C174271 imgt:ENZ-CARRIER_BIG_687|rdfs:comment|ENZ-CARRIER_BIG imgt:Product_823dd5e7-e3e3-3909-90c0-6b381ca01691|imgt:commun_name|SCB 313 imgt:IgG1-kappa_1205|rdfs:label|IgG1-kappa_1205 imgt:transforming_growth_factor_beta|skos:definition|transforming growth factor beta (TGFB or TGFbeta or TGF-beta, including TGF-beta-1 or TGFB1, TGF-beta-2 or TGFB2 or G-TsF and TGF-beta-3 or TGFB3) _:Bc8b5decf4f863650f32c350a9added5d|rdf:type|obo:NCIT_C53285 obo:RO_0001019|rdfs:range|faldo:Region imgt:EX2|rdf:type|imgt:C-RegionExonLabel imgt:Segment_608_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Leukemia|imgt:isClinicalIndicationOf|imgt:StudyProduct_7b861a94-9e6b-3cac-af47-59cbb1fad6a4 imgt:FN1-4|skos:definition|Fibronectin I imgt:mAb_793|rdfs:label|mAb_793 imgt:IgG1-kappa_MM_136|imgt:isMabReceptorOf|imgt:mAb_136 imgt:mAb_369|imgt:hasMabReceptor|imgt:IgG2-kappa_369 imgt:Construct_917|rdfs:label|Construct_917 imgt:Esophagitis_eosinophilic|imgt:isClinicalIndicationOf|imgt:StudyProduct_08a430cc-2e25-3c2f-a8b8-423cb63faac7 imgt:Chronic_lymphocytic_leukemia_(CLL)|imgt:isClinicalIndicationOf|imgt:StudyProduct_e672be16-de9f-37bd-a0e8-3f96dfdbe39d imgt:Segment_556_1|imgt:has_rank|1 imgt:mAb_635|rdf:type|obo:NCIT_C170293 imgt:Lymphoma_splenic_marginal_zone_(SMZL)|imgt:clinical_domain|Oncology imgt:IgG1-kappa-4cys-drug_784|rdfs:comment|IgG1 - kappa - 4cys - drug imgt:mAb_888|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=888 imgt:StudyProduct_988f16a7-b509-3d22-868d-d5da13250685|imgt:application_type|Therapeutic imgt:Product_e52c7cd4-ad8e-39a4-bf10-d325883a23cd|imgt:commun_name|APG-101 imgt:Clone_251|rdfs:label|Clone_251 imgt:Segment_242_1|rdfs:label|Segment_242_1 imgt:11391|rdfs:label|11391 imgt:Product_c49fe1bd-70e4-3192-91d0-1125b060119b|rdfs:label|Product_c49fe1bd-70e4-3192-91d0-1125b060119b imgt:mAb_811|imgt:inn_number|10764 imgt:Product_94b8ef04-33ad-342d-a8f0-5d3313872f31|rdfs:label|Product_94b8ef04-33ad-342d-a8f0-5d3313872f31 imgt:IgG1-kappa_713|rdf:type|imgt:MAbReceptor imgt:StudyProduct_5335348c-cd60-3fb3-a01c-4588efc82101|imgt:hasClinicalIndication|imgt:Lymphoma_splenic_marginal_zone_(SMZL) imgt:mAb_271|rdf:type|obo:NCIT_C95796 imgt:mAb_782|imgt:hasProduct|imgt:Product_3a22552f-e366-37f6-983c-ce759889e135 imgt:Segment_773_1|imgt:has_rank|1 imgt:mAb_552|imgt:hasProduct|imgt:Product_b73d2d86-860f-31ba-ad24-b3f898e384da imgt:Lymphocytopenia|rdfs:label|Lymphocytopenia imgt:mAb_379|imgt:inn_number|9465 imgt:StudyProduct_4388234b-49e5-3577-9d2d-284e40ef17be|imgt:development_technology| EBV immortalization imgt:Growth_hormone_(GH)_deficiency_pediatric|imgt:isClinicalIndicationOf|imgt:StudyProduct_b88b5151-dab0-3155-94aa-86dc1a096227 imgt:IgG4-kappa_922|imgt:hasMolecularComponent|imgt:IG imgt:mAb_279|imgt:inn_recommended_list|47 (2002) imgt:StudyProduct_2e1627be-7d57-3081-b019-6d6815084712|imgt:hasClinicalPhase|imgt:Phase_II imgt:Tumors|imgt:isClinicalIndicationOf|imgt:StudyProduct_dc244df2-4247-373b-a140-c4fc448f1daf imgt:Clone_1199|imgt:clone_name|SD30.06.F5.1G2.RHD1.6 imgt:PROTEIN_1DOMAIN_624|http://semanticscience.org/resource/SIO_000291|imgt:IFNAR1 imgt:9778|rdf:type|obo:NCIT_C25402 imgt:Construct_961|obo:BFO_0000051|imgt:Segment_961_1 imgt:Product_1f926dbc-c738-3aa1-a4fc-1a5a0ec04af8|imgt:commun_name|SI-636 imgt:Paroxysmal_nocturnal_hemoglobinuria_(PNH)|rdf:type|obo:NCIT_C185637 imgt:mAb_234|imgt:inn_recommended_list|60 (2008) imgt:Construct_307|imgt:hasImgtLabel|imgt:IgG1-nd imgt:LGR5|imgt:isTargetOf|imgt:IgG1-kappa_965 imgt:nepexto®|rdfs:comment| NEPEXTO® developed by Mylan N.V. (Canonsburg PA USA) approved by EMA on May 20 2020. EMEA/H/C/004711 Same clinical indications as ENBREL®. imgt:Construct_657|imgt:hasImgtLabel|imgt:IgG2-lambda imgt:mAb_1262|rdf:type|obo:NCIT_C1909 _:B42b89728a371f703c0e4a906a9738ba3|rdf:type|obo:NCIT_C53285 imgt:Product_3eac3ad8-0e0e-3905-b495-238bcb77e9cc|imgt:isProducedBy|imgt:University_of_California imgt:CH4-CHS|skos:definition|exon CH4-CHS of IG heavy C-GENE in gDNA _:Bb361c75360909c8d70e95248a223b73e|imgt:isDecidedBy|imgt:FDA imgt:mAb_258|imgt:hasProduct|imgt:Product_1c0d42d7-becf-3e27-853d-7f41e24430a7 imgt:Construct_1035|rdfs:label|Construct_1035 imgt:4F-DOMAIN|rdfs:label|4F-DOMAIN pubmed:16139892|dc:contributor|Kleindienst P imgt:IgG1-kappa_526|imgt:hasConstruct|imgt:Construct_526 _:Be66dfc3afacebf58a2f06926df590e8b|imgt:hasStatut|imgt:approval imgt:mAb_855|rdf:type|imgt:INN imgt:StudyProduct_894e7dce-e66b-3f46-8f3e-980db30eee88|imgt:application_type|Therapeutic imgt:Product_4f8eaec9-4859-3ace-a16d-f9d4aac8c48e|rdf:type|obo:NCIT_C51980 imgt:Product_ecb3c0eb-db31-3f63-a0a2-a59c047defae|imgt:hasStudyProduct|imgt:StudyProduct_ed93c1fc-3057-3d2e-be34-06ab0de17375 imgt:IgG2-lambda_664|imgt:isMabReceptorOf|imgt:mAb_664 imgt:Product_a22e1e73-39c4-3d58-810c-61a5fe2f2b92|rdfs:label|Product_a22e1e73-39c4-3d58-810c-61a5fe2f2b92 imgt:StudyProduct_a97a8d93-fa7e-3f39-ba19-1929fe3fab4c|imgt:application_type|Therapeutic imgt:Product_3e95582f-d686-389a-b368-f68cabf00d88|rdf:type|obo:NCIT_C51980 imgt:TGFB2|imgt:isTargetOf|imgt:IgG4-nd_182 imgt:StudyProduct_1892f39a-7a9d-3365-8bf8-9fb65c8dc355|imgt:application_type|Therapeutic imgt:Clone_1057|imgt:clone_name|E175150 obo:SO_0001248|owl:disjointWith|obo:SO_0000340 imgt:mAb_497|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=497 imgt:FN1-9|rdfs:label|FN1-9 imgt:IgG1-nd_39|rdfs:label|IgG1-nd_39 imgt:StudyProduct_a353023d-9680-3092-ac3d-9ddb5fe4e986|imgt:isStudyProductOf|imgt:Product_fb39e6e3-9a4c-3f5e-b00f-d8871ce8bb99 imgt:StudyProduct_8550c843-41ed-3b5a-8e2f-ac30570967bf|imgt:hasClinicalPhase|imgt:Phase_II imgt:StudyProduct_c12c2c3f-017f-38a5-bb6a-b9ee13b79491|imgt:isStudyProductOf|imgt:Product_1409f0bb-81d5-3a94-aea6-99517bf76035 imgt:Atherosclerosis|imgt:isClinicalIndicationOf|imgt:StudyProduct_d7dbd1df-30e9-30ba-a6db-d55ac8e4e78c imgt:Product_c9b09440-3c97-37f9-a7a3-a051cfd3499c|imgt:commun_name|BMA 031 imgt:Merus_NV|imgt:produces|imgt:Product_4a210fe1-cd13-31c5-a0f8-83e6e6417a4d obo:NCIT_C123734|rdf:type|owl:Class imgt:IG-Heavy-Delta-IGHD|imgt:defines|imgt:IgD_Kappa imgt:Product_822d4860-e4cc-3044-94aa-7b43f22ba9d7|rdfs:label|Product_822d4860-e4cc-3044-94aa-7b43f22ba9d7 imgt:IgG1-kappa_911|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:Segment_353_1|rdfs:label|Segment_353_1 imgt:Clone_320|rdfs:label|Clone_320 imgt:Crohn's_disease_(CD)|imgt:isClinicalIndicationOf|imgt:StudyProduct_5f4b56c5-0c22-3e10-b1fa-52d055ad6dc3 obo:NCIT_C171826|rdf:type|owl:Class imgt:mAb_493|rdf:type|imgt:INN imgt:Product_d829c3cd-3223-3480-91af-ae2450ad4b2d|imgt:commun_name|2H7 imgt:Product_d946876c-2d5b-39e7-947d-0c1325d80a31|imgt:hasStudyProduct|imgt:StudyProduct_586b45f8-08a4-32e7-9d7d-e3d745a847e3 imgt:Product_ee3787f8-7750-3f82-81f2-4aaf222c5ffd|rdf:type|obo:NCIT_C51980 imgt:isDefinedBy|rdf:type|owl:ObjectProperty _:Bf8f20c905d5f960e1ab2d562be53d4cd|imgt:isDecidedBy|imgt:FDA imgt:StudyProduct_cc62fbde-9763-3acc-84ea-d3a40efa698d|imgt:hasClinicalPhase|imgt:Phase_I/II imgt:StudyProduct_7027cb45-d588-3eb7-b1c2-d35ec6045bee|imgt:hasClinicalPhase|imgt:Phase_M imgt:mAb_921|imgt:inn_proposed_list|120 (2018) imgt:Product_3ac0b998-f720-388a-bb51-08f38d12f3e9|imgt:hasStudyProduct|imgt:StudyProduct_db6e4f8b-4477-3045-a47e-44e4aeaf8403 imgt:Clone_392|obo:RO_0002162|imgt:Homsap imgt:Segment_890_1|obo:BFO_0000050|imgt:Construct_890 imgt:F(ab’)2-Mu_Kappa|rdfs:label|F(ab’)2-Mu_Kappa imgt:11988|imgt:isImgtStructureEntryOf|imgt:mAb_1215 imgt:Segment_91_1|imgt:hasImgtLabel|imgt:IgG1-nd _:B6f08e6f29b2920b4a97aa5a2e843cc03|rdf:type|obo:NCIT_C53285 imgt:IgG4-kappa_430|rdfs:label|IgG4-kappa_430 imgt:IgG1-kappa_534|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:mAb_396|imgt:hasImgtStructureEntry|imgt:8824 imgt:StudyProduct_3c2f61fd-a181-3f7a-89d4-514b329385c0|rdf:type|obo:NCIT_C174271 _:B68929fa587f49ae1e6aa3f2c9b06f209|dc:date|2006-06-05 imgt:Hepatocellular_carcinoma_(HCC)|imgt:isClinicalIndicationOf|imgt:StudyProduct_ba0ee284-ffae-354b-a756-2e4106d53de8 imgt:mAb_909|imgt:hasProduct|imgt:Product_7cd6bccd-e113-3f71-b694-1ad929718792 imgt:mAb_458|rdf:type|imgt:INN imgt:mAb_719|imgt:inn_proposed_list|116 (2016) imgt:FAB-ALPHA-1_KAPPA|rdfs:label|FAB-ALPHA-1_KAPPA obo:NCIT_C152697|rdfs:subClassOf|obo:NCIT_C1909 imgt:Product_bb7aebc4-a07c-3a88-9fc9-cf9cf1d066cd|rdfs:label|Product_bb7aebc4-a07c-3a88-9fc9-cf9cf1d066cd imgt:mAb_161|imgt:hasProduct|imgt:Product_33e35737-1cde-3654-a2bb-0b350fcde7dd imgt:StudyProduct_e5918f1b-dab3-337e-9cbd-91ad992f0a2a|rdfs:label|StudyProduct_e5918f1b-dab3-337e-9cbd-91ad992f0a2a _:B81a8330f9679fd975f7294a5df366b32|imgt:isDecisionOf|imgt:StudyProduct_78170e97-70c1-3171-ae0d-f8c67e83e3be _:B1c539c6c2eb91c2d880ca625b07b0fb7|imgt:hasStatut|imgt:approval imgt:StudyProduct_3365e494-cd15-3232-a8be-a08afe6dced2|imgt:application_type|Therapeutic imgt:mAb_595|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=595 imgt:IgG1-kappa_603|rdf:type|imgt:MAbReceptor imgt:PEPTIDE_705|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/PEPTIDE.png imgt:11634|rdf:type|obo:NCIT_C25402 imgt:IgG2-G4-kappa_674|rdfs:label|IgG2-G4-kappa_674 imgt:J-CLUSTER|rdfs:label|J-CLUSTER imgt:mAb_350|rdfs:label|mAb_350 imgt:Solid_tumors|imgt:isClinicalIndicationOf|imgt:StudyProduct_c590987d-b263-3358-8d7d-0b194188970c imgt:StudyProduct_32c61a15-2c8b-3f79-bbad-89bdad015cc7|rdf:type|obo:NCIT_C174271 imgt:Construct_245|rdfs:label|Construct_245 imgt:Product_7b6e3c54-31d7-3948-b87d-dec2c46600ca|rdfs:label|Product_7b6e3c54-31d7-3948-b87d-dec2c46600ca imgt:Bostau_FSHR|rdf:type|obo:NCIT_C25702 imgt:StudyProduct_03422200-29c5-3ece-ad85-46a6799f36a1|imgt:application_type|Therapeutic imgt:Alector|rdfs:comment|San Francisco , USA imgt:IgG1-nd_MM_268|imgt:isMabReceptorOf|imgt:mAb_268 imgt:Heterozygous_familial_hypercholesterolemia_(HeFH)|imgt:isClinicalIndicationOf|imgt:StudyProduct_ae822dac-06fe-33c0-b05f-6cf9fff03cd1 imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_7d774341-2500-3316-9259-6bbd4b727973 imgt:Product_d80bdb56-4a05-3d99-ab25-22438984eabb|imgt:comercial_name|ERBITUX® imgt:grastofil|rdfs:comment| GRASTOFIL (filgrastim) developed by Apotex Inc. (Toronto ON Canada) approved in the EU by EC on October 18 2013. Same clinical indications as NEUPOGEN®. _:Bf0ba6aa42c00432cb9318ec3944c64f0|dc:date|2014-09-18 imgt:IgG1-kappa_801|obo:RO_0002162|imgt:Hum obo:NCIT_C142978|rdfs:subClassOf|obo:NCIT_C1909 imgt:IgG1-kappa_143|imgt:hasConstruct|imgt:Construct_143 imgt:mAb_734|imgt:hasProduct|imgt:Product_9ea2b798-1165-3baf-bd8a-5cfbd561adc2 imgt:L-V-D-J-REGION|rdfs:label|L-V-D-J-REGION imgt:StudyProduct_5847041b-ebca-314e-896a-d8779fdc619a|rdfs:label|StudyProduct_5847041b-ebca-314e-896a-d8779fdc619a imgt:11704|rdf:type|obo:NCIT_C25402 imgt:StudyProduct_a7f358ba-3750-38cd-90ed-282ce24e69fa|imgt:hasDecision|_:B4cc13ea090d1d004fb1c63fb7b02fa56 imgt:Construct_895|imgt:isConstructOf|imgt:FPIA_%5BPROTEIN_2REPEATS%5D2-FC_895 imgt:Product_ed5e913a-f7f4-32d3-aab5-2a234ed41808|rdf:type|obo:NCIT_C51980 imgt:StudyProduct_7dba069b-48d2-3823-bcf0-5ae588109822|rdf:type|obo:NCIT_C174271 imgt:3C-LIKE|rdf:type|imgt:ChainLabels imgt:Construct_952|rdfs:label|Construct_952 imgt:10653|imgt:isImgtStructureEntryOf|imgt:mAb_797 imgt:IgG1-kappa_MM_138|rdf:type|imgt:MAbReceptor imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_d0b9c36a-47a6-3ed4-963a-755e65fcf1c4 imgt:StudyProduct_7c3ef30a-9ded-3a0d-a265-52ddf17bf64a|imgt:hasClinicalIndication|imgt:Fracture_healing imgt:Product_44f47fcb-04de-39c1-99a4-99e993c867a7|imgt:hasStudyProduct|imgt:StudyProduct_51e920fa-6dd4-3063-86b9-6d6030c2fba6 imgt:IgG1-nd_67|rdfs:comment|IgG1 - nd imgt:mAb_374|imgt:inn_number|9380 imgt:Segment_768_1|imgt:hasImgtLabel|imgt:IgG1-kappa _:B44b00ca3ed0e13e7f8e40d6b325745a7|dc:date|1989-06-01 imgt:Segment_245_1|rdfs:label|Segment_245_1 imgt:IgG1-lambda2-%5BscFv-heavy-kappa%5D2|rdf:type|imgt:ConstructLabels _:Bbc3f4384778bbbad4804ea4eaa927d0f|imgt:isDecidedBy|imgt:FDA imgt:IgG4-kappa-lambda_973|rdfs:label|IgG4-kappa-lambda_973 imgt:HYDROPHILIC-REGION|rdfs:label|HYDROPHILIC-REGION imgt:Segment_1024_1|rdf:type|imgt:Segment imgt:mAb_549|rdfs:label|mAb_549 imgt:9611|imgt:isImgtStructureEntryOf|imgt:mAb_431 imgt:StudyProduct_db2405b4-3c00-39c2-a8e3-2ad1c51f9e46|imgt:hasClinicalIndication|imgt:Rheumatoid_arthritis_(RA) imgt:StudyProduct_65221f3b-9a94-3ca8-ad82-6317e64f14f1|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:Anemia_in_chronic_kidney_disease-related_(CKD)|imgt:isClinicalIndicationOf|imgt:StudyProduct_33faeb62-9c6d-3140-98f2-c046c2f59f9b imgt:Product_f21edd5d-c119-3b27-a5be-d51a4f2ba15a|imgt:hasStudyProduct|imgt:StudyProduct_b8106473-d3b6-3d61-9e30-c839ccb0de0c imgt:mAb_1111|rdfs:label|mAb_1111 imgt:CD38|imgt:isTargetOf|imgt:IgG1-kappa_539 imgt:mAb_765|imgt:hasProduct|imgt:Product_5ce3b46d-9c42-34a1-a25d-2571a2d48a7a imgt:Product_be7fe1ac-60ec-3e93-a36a-4383c0cb79ad|imgt:hasStudyProduct|imgt:StudyProduct_a4335940-34a0-3627-b2ea-b3c189aa7893 imgt:Stroke|imgt:isClinicalIndicationOf|imgt:StudyProduct_80933e31-5799-3fb9-ac07-938d123d3dba _:B302fc6aff28077b8e9102d5f7f437ddc|rdf:type|obo:NCIT_C53285 imgt:StudyProduct_be02d32a-6ad4-379d-9706-be3394ebebfc|rdfs:label|StudyProduct_be02d32a-6ad4-379d-9706-be3394ebebfc imgt:StudyProduct_15a257d3-e7cf-393d-9482-4fadc2a060bb|rdf:type|obo:NCIT_C174271 imgt:G1-kappa_scFv-HEAVY-KAPPA-h-CH2-CH3_1084|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/G1-kappa_scFv-HEAVY-KAPPA-h-CH2-CH3.png imgt:Product_d1cda899-6b1f-3fc5-9c4c-cb14c62b0c13|imgt:isProducedBy|imgt:Human_Genome_Sciences_Inc_(HGSI) imgt:IgG4-kappa_1010|rdfs:comment|IgG4 - kappa https://doi.org/10.1093/protein/7.12.1501|dc:contributor|Gray P.M. imgt:Merkel_cell_carcinoma_(MCC)_metastatic|imgt:isClinicalIndicationOf|imgt:StudyProduct_83022c95-c34d-302b-ac2f-5a4982727495 imgt:Product_f164296f-9a73-3f69-b8b0-65757f1c83b3|imgt:commun_name|CY-174 imgt:codes|rdfs:label|codes imgt:SORT1|skos:definition|SORT1 (sortilin 1, Gp95, NT3) imgt:IgG1-kappa_71|rdfs:label|IgG1-kappa_71 imgt:Anemia_associated_with_chronic_renal_failure|imgt:isClinicalIndicationOf|imgt:StudyProduct_6bcaa017-20d4-3c2e-a4d7-adb692916142 imgt:mAb_280|imgt:inn_recommended_list|46 (2001) imgt:mAb_106|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=106 imgt:StudyProduct_6c72d938-cfba-3c0d-921d-4fc1c714512d|rdfs:label|StudyProduct_6c72d938-cfba-3c0d-921d-4fc1c714512d imgt:Construct_79|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Segment_1005_1|imgt:has_rank|1 imgt:MAbReceptor_145|http://semanticscience.org/resource/SIO_000291|imgt:CEACAM5 imgt:TNFSF18_(Pr1-199)|rdfs:label|TNFSF18 (Pr1-199) imgt:Neuromyelitis_optica_(NMO)|imgt:isClinicalIndicationOf|imgt:StudyProduct_e11efdd3-ff61-3f7d-bfdf-71a48aecb94f imgt:IgG1-kappa_911|obo:RO_0002162|imgt:Hum imgt:IgG1-kappa-lambda|rdf:type|imgt:ConstructLabels imgt:mAb_951|rdf:type|obo:NCIT_C175072 imgt:mAb_949|imgt:hasImgtStructureEntry|imgt:11078 imgt:StudyProduct_ba0ee284-ffae-354b-a756-2e4106d53de8|rdf:type|obo:NCIT_C174271 imgt:Amgen|imgt:produces|imgt:Product_372d02b4-b16a-3ff3-89fa-2a311590437e imgt:IgG1-kappa_1239|imgt:hasConstruct|imgt:Construct_1239 imgt:Product_8bdb3425-f72a-3777-be41-82fdaed26099|imgt:commun_name|bscCD19xCD3 imgt:IL12A|obo:RO_0002162|imgt:Homsap imgt:StudyProduct_7a614fd0-6c32-3499-b168-0b9896beedeb|imgt:isStudyProductOf|imgt:Product_7a614fd0-6c32-3499-b168-0b9896beedeb _:Bcccdec547856261b5180d293ed013ea3|imgt:isDecisionOf|imgt:StudyProduct_02e6ed45-1e3c-3d4d-bdc7-e3ccfeb40215 imgt:C-LIKE|skos:definition|coding region of a constant (C) domain in IgSF other than IG or TR, C-LIKE-DOMAIN in IMGT-ONTOLOGY imgt:Construct_549|rdf:type|imgt:Construct imgt:10709|imgt:isImgtStructureEntryOf|imgt:mAb_800 imgt:Construct_697|imgt:isConstructOf|imgt:HOR-CTP_697 imgt:Clone_493|obo:RO_0002162|imgt:Musmus imgt:Segment_567_1|rdfs:label|Segment_567_1 imgt:StudyProduct_50e27e1f-c4ca-30c3-829c-f5be1400c86f|rdfs:label|StudyProduct_50e27e1f-c4ca-30c3-829c-f5be1400c86f imgt:Product_e9daee39-798c-31b1-90f7-fbe193e666ef|imgt:isProductOf|imgt:mAb_199 imgt:BioAtla_LLC|imgt:produces|imgt:Product_1c7d468c-7793-33f3-a5bd-6747d51e1199 imgt:StudyProduct_4e6bde7e-d321-3797-854b-8b18ca0ae17f|imgt:hasClinicalPhase|imgt:Phase_I imgt:Segment_418_1|rdf:type|imgt:Segment imgt:IgG4-kappa-protein_982|imgt:via_a| peptidyl linker imgt:Fab-Gamma-2-a_Lambda|imgt:isDefinedBy|imgt:IG-Heavy-Gamma-2-a-IGHG2A imgt:IgG1-kappa_770|imgt:hasMolecularComponent|imgt:IG imgt:IgG1-V-lambda-C-kappa_834|rdfs:label|IgG1-V-lambda-C-kappa_834 imgt:mAb_597|rdf:type|obo:NCIT_C119620 imgt:StudyProduct_9d114592-9c19-35b3-b1d2-8ffb010769f5|imgt:isStudyProductOf|imgt:Product_c2a35708-7257-3084-8079-8ca3bcca6373 _:B1227de591dc3b799ce2b98589e1b7754|imgt:isDecidedBy|imgt:FDA imgt:_E.coli_(Escherichia_coli)|imgt:isExpressionSystemOf|imgt:StudyProduct_45b6062e-6ed8-34fb-baf5-fa526b0c3293 imgt:%5BACVR2A_(activin_A_receptor_type_2A_ActR-II_ActRIIA)%5D2-IGHG1_Fc_(Fragment_constant)|rdf:type|imgt:ConstructLabels imgt:PGF|obo:RO_0002162|imgt:Homsap imgt:Solid_tumors|imgt:isClinicalIndicationOf|imgt:StudyProduct_de4ef407-46a7-3d97-9488-c7f2d1ac5324 imgt:mAb_100|rdfs:label|mAb_100 imgt:mAb_955|rdf:type|obo:NCIT_C128138 imgt:Product_cf2f7fdd-756d-34db-a0a8-796cf3a5e368|rdfs:label|Product_cf2f7fdd-756d-34db-a0a8-796cf3a5e368 imgt:mAb_815|imgt:hasMabReceptor|imgt:IgG1-kappa-2cys-drug_815 imgt:FC-ALPHA-1|skos:definition|Fc comprising the CH2-CH3 domains from two H-ALPHA-1 chains imgt:Hodgkin_lymphoma|imgt:isClinicalIndicationOf|imgt:StudyProduct_6f1c296e-aefa-346a-ae77-b60731c49c21 imgt:StudyProduct_b9782cd6-eaaa-3fb3-ad90-ce4d8add7cf8|imgt:hasClinicalPhase|imgt:Phase_M imgt:Clone_1260|rdfs:label|Clone_1260 imgt:IgG1-kappa_381|rdfs:label|IgG1-kappa_381 imgt:Product_eaff1a64-336d-3769-a307-839a1345fa9b|imgt:hasStudyProduct|imgt:StudyProduct_d5c67ac7-981f-3c29-bfc0-5cb699da847b pubmed:7719381|rdfs:label|PMID_7719381 imgt:F(ab’)2-Gamma-2-a_Kappa|imgt:isDefinedBy|imgt:IG-Light-Kappa-IGKC imgt:IgG1-lambda_154|rdfs:label|IgG1-lambda_154 imgt:StudyProduct_19ea95d6-4b35-3939-84cd-0f984c67a91e|imgt:isStudyProductOf|imgt:Product_1aa37c1d-0409-3829-ba45-a5a52bab10aa imgt:StudyProduct_6f051fa3-85d4-36c5-8882-7d93ca861a8f|imgt:hasClinicalPhase|imgt:Phase_II imgt:IgG1-nd_743|rdf:type|imgt:MAbReceptor imgt:StudyProduct_f0f1e1ce-cf78-34af-a7f5-28dc4eb92819|rdf:type|obo:NCIT_C174271 imgt:Clone_681|rdfs:label|Clone_681 imgt:mAb_376|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=376 imgt:mAb_91|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=91 imgt:mAb_430|imgt:inn_number|9626 imgt:Clone_55|obo:RO_0002162|imgt:Musmus imgt:StudyProduct_84e32db6-70db-3328-968a-3daaa74a54bd|imgt:hasExpressionSystem|imgt:_COS_cells_transient_expression imgt:Diffuse_scleroderma|rdfs:label|Diffuse_scleroderma imgt:Product_f54c6043-6277-3c37-b202-92f1deb4aaff|imgt:hasStudyProduct|imgt:StudyProduct_63df4182-a56c-3791-98cd-3d2446f520ce imgt:IgG2-kappa_495|rdfs:comment|IgG2 - kappa imgt:StudyProduct_08a430cc-2e25-3c2f-a8b8-423cb63faac7|imgt:isStudyProductOf|imgt:Product_d477f5f5-42d6-3980-b64d-c8478f661338 imgt:J-RS-V-RS|rdfs:label|J-RS-V-RS imgt:IgG1-kappa_234|rdf:type|imgt:MAbReceptor imgt:Segment_837_1|rdfs:label|Segment_837_1 imgt:IgG1-kappa_416|imgt:hasConstruct|imgt:Construct_416 imgt:IgG1-kappa_428|rdfs:comment|IgG1 - kappa imgt:mAb_153|imgt:hasProduct|imgt:Product_30984d74-c01e-3818-be62-a95c03ad4613 imgt:GENE-UNIT|skos:definition|gDNA of a GENE unit, in undefined configuration, that comprises exons (EXON) and introns (INTRON), from the first nucleotide of the first exon to STOP-CODON (included) after the last exon imgt:IgG2-kappa_485|rdfs:label|IgG2-kappa_485 imgt:Product_6b42a0d3-1383-3dc2-a533-4f51868e60f6|imgt:isProducedBy|imgt:Novartis_Pharmaceuticals_Corp imgt:IgG1-kappa_966|rdfs:label|IgG1-kappa_966 imgt:Clone_126|obo:RO_0002162|imgt:Musmus imgt:Solid_tumors|imgt:isClinicalIndicationOf|imgt:StudyProduct_026b75f7-c995-3045-a2f6-daa0a331f298 imgt:MAbReceptor_195|http://semanticscience.org/resource/SIO_000291|imgt:HBV imgt:11067|rdfs:label|11067 imgt:MAbReceptor_141|obo:RO_0002162|imgt:Musmus imgt:Construct_263|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:StudyProduct_ca42b321-4efb-3ab3-95da-0abbfe6974d2|imgt:hasDecision|_:Baf7aa46a259ddeb55b86dbc4c2c3d7c3 imgt:FC-%5BPEPTIDE-PEPTIDE%5D2_408|rdf:type|imgt:MAbReceptor imgt:StudyProduct_8e98d81f-8217-3049-b5cc-b23337bb5761|rdf:type|obo:NCIT_C174271 imgt:mAb_1009|imgt:inn_name|ezabenlimab imgt:IgG1-kappa_175|imgt:hasConstruct|imgt:Construct_175 imgt:Product_410df2c2-31fc-38b5-a007-2574a4c85dde|rdf:type|obo:NCIT_C51980 imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_51a1fdf9-8ac4-37ed-93b1-39ba82b939db imgt:Segment_986_1|rdf:type|imgt:Segment imgt:Neutropenia_chemotherapy-induced|imgt:isClinicalIndicationOf|imgt:StudyProduct_a48bfd5b-9ac9-3abf-8bec-58e5195c9cee imgt:10142|rdfs:label|10142 imgt:StudyProduct_d9de3271-d27d-3eef-9954-73b08ec0a651|imgt:application_type|Therapeutic obo:NCIT_C170293|rdfs:subClassOf|obo:NCIT_C1909 imgt:Construct_1150|rdf:type|imgt:Construct imgt:1C-LIKE_1C-LIKE|skos:definition|Receptor comprising two chains both with one C-LIKE domain imgt:mAb_578|rdf:type|obo:NCIT_C99640 obo:NCIT_C103820|rdfs:subClassOf|obo:NCIT_C1909 imgt:mAb_995|imgt:hasProduct|imgt:Product_b5c12b2c-3e4c-373e-aa68-cadfb8ccd5f9 imgt:mAb_584|rdf:type|obo:NCIT_C1909 pubmed:16699037|dc:contributor|Eda Y imgt:mAb_1249|imgt:hasOriginClone|imgt:Clone_1249 imgt:StudyProduct_610139e9-1ad4-34aa-99d3-50d54729d262|imgt:isStudyProductOf|imgt:Product_1c81621a-ff42-3937-8f41-30279f630940 imgt:TR-Gamma-4-TRGC4|imgt:isDescribedBy|imgt:TR-GAMMA-4 imgt:Construct_572|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Asthma_severe|imgt:isClinicalIndicationOf|imgt:StudyProduct_6db50714-0662-3bff-8367-a5e5b3264568 imgt:mAb_1222|imgt:hasProduct|imgt:Product_827a202e-1f6c-316d-b5b0-b1ebd391a8c6 imgt:mAb_967|imgt:hasImgtStructureEntry|imgt:10939 imgt:StudyProduct_7a8a4321-2c20-3c9b-b98e-ac1a3008529e|imgt:hasClinicalPhase|imgt:Phase_I imgt:PROTEIN_1DOMAIN_997|obo:RO_0002162|imgt:Homsap imgt:Segment_701_4|imgt:has_rank|4 imgt:mAb_1105|imgt:inn_proposed_list|124 (2020) imgt:IgG1-V-lambda-C-kappa_856|rdfs:label|IgG1-V-lambda-C-kappa_856 imgt:StudyProduct_fe683cf1-3e60-38cf-9475-d6d80b127665|imgt:hasDecision|_:Bb7e5f383a970a09ebfb64c147dd03f75 imgt:IgG1-kappa_1146|rdf:type|imgt:MAbReceptor imgt:StudyProduct_0b901008-e639-31ff-9178-ec6678c2f98a|imgt:hasClinicalIndication|imgt:Hepatocellular_carcinoma_(HCC) pubmed:21170091|rdfs:label|PMID_21170091 imgt:Increased_levels_of_IL6_in_sepsis|imgt:clinical_domain|Immunology imgt:mAb_411|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=411 imgt:mAb_775|imgt:inn_name|camidanlumab tesirine imgt:IgG1-lambda-kappa_949|rdfs:label|IgG1-lambda-kappa_949 imgt:mAb_642|imgt:hasImgtStructureEntry|imgt:10213 imgt:IgG1-kappa_362|rdf:type|imgt:MAbReceptor imgt:Giant_cell_arteritis|imgt:isClinicalIndicationOf|imgt:StudyProduct_4c044125-ddc6-3ee4-a8a4-cfbe742e6499 imgt:GCG_(glucagon)_53-89_(oxyntomodulin_OXM)|rdf:type|imgt:ConstructLabels imgt:PROTEIN_1DOMAIN_639|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/PROTEIN_1DOMAIN.png imgt:StudyProduct_d84bded9-4720-3ab6-acaf-6d8202bfa9d7|imgt:application_type|Therapeutic imgt:Construct_6|imgt:hasImgtLabel|imgt:IgG1-nd imgt:Product_68ba4461-b5a0-3c71-bc9b-64306af5f891|imgt:isProductOf|imgt:mAb_1037 imgt:StudyProduct_e830e5de-f880-323f-a30f-b17d9e9b6a9e|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_280d1c05-63f1-3caa-830e-5c037b28d442|rdfs:label|StudyProduct_280d1c05-63f1-3caa-830e-5c037b28d442 imgt:Construct_485|obo:BFO_0000051|imgt:Segment_485_1 imgt:StudyProduct_ae0a2f19-2fc1-33ab-b4fb-04b390db4fe8|imgt:application_type|Therapeutic imgt:Product_e98a7b41-0f51-3064-ae4a-a9ee58d6b895|imgt:isProductOf|imgt:mAb_155 imgt:IgG1-kappa_810|rdf:type|imgt:MAbReceptor obo:NCIT_C170363|rdfs:subClassOf|obo:NCIT_C1909 imgt:StudyProduct_cb415f04-8f17-3d90-b008-249903036395|rdfs:label|StudyProduct_cb415f04-8f17-3d90-b008-249903036395 _:B328bd279185f2df13207d58d813b8c68|imgt:hasDesignation|imgt:Orphan_drug imgt:Short_bowel_syndrome_(SBS)|imgt:isClinicalIndicationOf|imgt:StudyProduct_e26eb2da-db55-3627-863a-e1eb92a9277d imgt:Low_bone_mineral_density|rdf:type|obo:NCIT_C185637 imgt:FUSION-(Oxyntomodulin_analog_PEG_linker)_-FC-GAMMA-4|skos:definition|Fusion protein for immune application (FPIA) comprising Oxyntomodulin analog - PEG fused with immunoglobulin G4 FC fragment imgt:Product_cd3bec45-390a-31ab-b8e2-3ad6f87b4c5e|rdf:type|obo:NCIT_C51980 https://doi.org/10.1093/protein/7.12.1501|dc:contributor|Harris W.J. imgt:IgG1-kappa_907|rdfs:label|IgG1-kappa_907 imgt:EPCAM|imgt:isTargetOf|imgt:IgG2a-kappa_119 imgt:Systemic_juvenile_idiopathic_athritis_(SJIA)|imgt:isClinicalIndicationOf|imgt:StudyProduct_da8191ac-8a89-3cd3-a4f5-49711ae61d86 imgt:scFv-kappa-heavy-scFv-kappa-heavy-CD4(CO-TM-CY)_1232|rdfs:label|scFv-kappa-heavy-scFv-kappa-heavy-CD4(CO-TM-CY)_1232 imgt:Clone_1104|rdf:type|obo:NCIT_C37925 _:B88aa803a0d65eabb3bc1b141e6f201de|imgt:isDecisionOf|imgt:StudyProduct_75da9afc-c396-3742-980d-42556285d8c2 imgt:CD74|imgt:isTargetOf|imgt:MAbReceptor_880 imgt:mAb_583|imgt:hasImgtStructureEntry|imgt:11142 imgt:Product_c43354f7-d1ee-3952-bf61-d7f3d2f18d35|imgt:commun_name|PSB-205 imgt:StudyProduct_f9d091c1-0d73-3ff4-b753-7ffab31fd62b|imgt:hasClinicalIndication|imgt:Non-Hodgkin's_lymphoma_(NHL) imgt:IgG1-kappa_1153|http://semanticscience.org/resource/SIO_000291|imgt:PDCD1 _:B759fd34b8ba33c84032ffae975bf88d3|rdf:type|obo:NCIT_C53285 imgt:StudyProduct_73efe3b5-92db-30db-bd60-e6ce0edfe013|imgt:hasClinicalPhase|imgt:Phase_I imgt:StudyProduct_3c2e8c1b-f3e7-3e3d-a63e-6d7ce37909f2|imgt:isStudyProductOf|imgt:Product_60e9fa18-d4b5-3b41-999a-e61a0ca37372 imgt:mAb_297|rdfs:label|mAb_297 imgt:IgG1-kappa_861|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_29f68c3f-6531-3a40-a091-1f002b14d6b7 imgt:Clone_17|imgt:isOriginCloneOf|imgt:mAb_17 imgt:CY-PART2|skos:definition|exon or part of exon of C-GENE-UNIT, GENE-UNIT or L-GENE-UNIT, coding the second part of the CYTOPLASMIC-REGION, in gDNA pubmed:10597336|dc:contributor|Present DH imgt:Segment_1116_1|rdf:type|imgt:Segment imgt:StudyProduct_5b15ac0a-e17c-36ed-a2c5-c61a91197d16|imgt:hasClinicalIndication|imgt:Solid_tumors imgt:IG-Heavy-Alpha-1-IGHA1|imgt:defines|imgt:IgA1_Kappa imgt:complement_C3b,_C4b|rdf:type|obo:NCIT_C25702 imgt:PROTEIN_1DOMAIN_639|http://semanticscience.org/resource/SIO_000291|imgt:IFNAR2 imgt:Product_a0ec6f87-28fe-3db8-b9ac-2a212fe42735|imgt:hasStudyProduct|imgt:StudyProduct_da550ada-9aaa-3da4-a461-f434dc605d65 imgt:StudyProduct_3593e4ce-f227-33e4-a62d-662cc6212276|imgt:hasClinicalIndication|imgt:Acute_kidney_transplant_rejection imgt:IgG2-kappa_586|imgt:hasConstruct|imgt:Construct_586 imgt:Construct_743|rdfs:label|Construct_743 imgt:Segment_385_1|rdfs:label|Segment_385_1 imgt:StudyProduct_10c15faf-70fb-3e1e-a58d-d35c73cb073d|imgt:isStudyProductOf|imgt:Product_8e8a1379-1ce0-3a6f-bd30-ded74b8a8b53 imgt:IgG2-kappa_975|http://semanticscience.org/resource/SIO_000291|imgt:CEACAM6 imgt:Segment_625_1|imgt:segment_detail|*a (K56,H57)  24-188 imgt:IgG1-kappa_965|imgt:isMabReceptorOf|imgt:mAb_965 imgt:Construct_247|rdf:type|imgt:Construct imgt:Cancers_colorectal_microsatellite_stable_metastatic|imgt:isClinicalIndicationOf|imgt:StudyProduct_5ad216b8-500b-3277-b707-593d56627e1d imgt:Product_3324747e-377b-32d2-95cf-77fa2a26537b|imgt:isProductOf|imgt:mAb_676 imgt:mAb_161|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=161 imgt:Clone_252|rdf:type|obo:NCIT_C37925 imgt:StudyProduct_9ac34664-9570-3c7d-90b6-3eb23cd0e79b|imgt:isStudyProductOf|imgt:Product_a0ad7eed-cb27-395a-a42a-66344074cbf9 pubmed:7691407|dc:contributor|Hansen HJ obo:NCIT_C166809|rdf:type|owl:Class imgt:Product_1f926dbc-c738-3aa1-a4fc-1a5a0ec04af8|rdfs:label|Product_1f926dbc-c738-3aa1-a4fc-1a5a0ec04af8 pubmed:7688398|dc:contributor|Crowe J.S. imgt:HBV|imgt:isTargetOf|imgt:MAbReceptor_195 imgt:Product_60d67764-c42e-3595-b0ea-20f088fd5134|rdfs:label|Product_60d67764-c42e-3595-b0ea-20f088fd5134 imgt:Group|rdfs:subClassOf|imgt:CLASSIFICATION imgt:ILDR2|rdfs:label|ILDR2 imgt:StudyProduct_a4727270-51a2-39ad-a4c3-e1c0fa7af61a|imgt:hasClinicalPhase|imgt:Phase_M imgt:StudyProduct_abd6f0a5-7c5e-36fb-8b5c-0c9d2b6fbc0f|imgt:hasClinicalIndication|imgt:Chronic_Obstructive_Pulmonary_Disease_(COPD) imgt:IgG4-kappa_1128|obo:RO_0002162|imgt:Hum imgt:exemptia™|imgt:isBiosimilarOf|imgt:mAb_165 imgt:Cancers_bladder|imgt:isClinicalIndicationOf|imgt:StudyProduct_5366ddef-ab99-306b-8386-88bf093ea87c imgt:IgG1-kappa_1255|imgt:hasConstruct|imgt:Construct_1255 imgt:Segment_97_1|rdf:type|imgt:Segment imgt:FPIA_%5BPROTEIN-PROTEIN%5D2-FC_214|rdfs:comment|FPIA_[PROTEIN-PROTEIN]2-FC imgt:UCB|imgt:produces|imgt:Product_9dc2e6e7-02dc-385a-9448-66778b7d71e6 imgt:IgG1-lambda_456|http://semanticscience.org/resource/SIO_000291|imgt:ACVR2B obo:NCIT_C175057|rdfs:subClassOf|obo:NCIT_C1909 imgt:IgG1-kappa-%5BPROTEIN%5D3_1224|http://semanticscience.org/resource/SIO_000291|imgt:TNFRSF9 imgt:TNFRSF1B|rdf:type|imgt:SegmentLabels imgt:mAb_1182|imgt:hasOriginClone|imgt:Clone_1182 imgt:Segment_837_1|rdf:type|imgt:Segment imgt:Chronic_focal_encephalitis_(CFE)|imgt:isClinicalIndicationOf|imgt:StudyProduct_10c15faf-70fb-3e1e-a58d-d35c73cb073d imgt:Segment_1258_2|rdfs:label|Segment_1258_2 imgt:StudyProduct_c12552c1-785b-3f94-a4be-35098da2b6a4|imgt:hasClinicalPhase|imgt:Phase_I imgt:Segment_800_1|rdf:type|imgt:Segment obo:NCIT_C124657|rdf:type|owl:Class imgt:Construct_334|rdf:type|imgt:Construct imgt:StudyProduct_07f88f08-8bb3-39d1-8416-508d41a38406|imgt:isStudyProductOf|imgt:Product_3086b99e-8c37-3a44-8aaf-14e046e82b3b imgt:Segment_825_2|imgt:has_rank|2 imgt:Product_8bc22827-09a3-3eb0-9e53-3f97c122310c|imgt:commun_name|STRO-002 imgt:StudyProduct_812f296e-7064-3e1d-94f1-0375c707bb67|imgt:hasClinicalIndication|imgt:Chronic_idiopathic_urticaria imgt:StudyProduct_f0f1e1ce-cf78-34af-a7f5-28dc4eb92819|imgt:application_type|Therapeutic imgt:Construct_248|obo:BFO_0000051|imgt:Segment_248_1 imgt:Stroke|imgt:isClinicalIndicationOf|imgt:StudyProduct_3cf885c8-c7b2-3a9b-b637-6fadb2324fb9 imgt:StudyProduct_7c05cd89-2d1f-3b01-9c83-8836b75f6859|imgt:hasClinicalPhase|imgt:Phase_I imgt:Product_ca787b24-c30a-385c-9bcd-68ea3ca43a59|rdf:type|obo:NCIT_C51980 imgt:Segment_1264_1|rdfs:label|Segment_1264_1 imgt:LHCGR|obo:RO_0002162|imgt:Homsap _:B6940295421591c166e47db2cef5c9b59|dc:date|2014-08-22 imgt:CPCA_PEPTIDE-PEG-FC_830|imgt:hasMolecularComponent|imgt:CPCA imgt:AbbVie_Inc|imgt:produces|imgt:Product_c7f1d535-33e6-32f8-8320-06c648b7ccc4 imgt:AbbVie_Inc|imgt:produces|imgt:Product_0b4e1466-29cd-32e4-b3ad-f86464d82272 imgt:StudyProduct_e7d55985-d5f8-3eb2-98ae-964a79e5b78a|imgt:hasClinicalIndication|imgt:Migraine imgt:VLRA|rdfs:label|VLRA imgt:Product_3d84c16b-3f37-3fd2-9308-fb662b4b198e|imgt:isProductOf|imgt:mAb_775 _:B5cf1a7a8f03360c45949e3441ef448c5|imgt:isDecidedBy|imgt:EMA pubmed:9140729|rdfs:label|PMID_9140729 imgt:Product_a75e30cc-34a4-3dcd-be39-36d249d9bb92|imgt:commun_name|AMG-412 imgt:IG-Heavy-Gamma-2-c-IGHG2C|imgt:defines|imgt:Fc-Gamma-2-c imgt:Segment_44_1|imgt:has_rank|1 imgt:IL22_(interleukin_22_IL-22_ILTIF_IL-TIF)-IGHG4_Fc_(Fragment_constant)|rdf:type|imgt:ConstructLabels imgt:StudyProduct_bf9c4751-a32e-3ad6-a1c3-f8822432d8d2|imgt:hasDecision|_:B492f7a171f6893175f5f7d59a6354817 imgt:mAb_24|imgt:hasProduct|imgt:Product_60d50ddc-7055-3124-936b-1628e2af1236 pubmed:8360482|dc:contributor|Gorman CM imgt:StudyProduct_5893f77a-8ead-33d5-accb-55e4c2563b5d|imgt:hasClinicalIndication|imgt:Cancers imgt:StudyProduct_70b9a532-ec91-3494-b50f-e40c7adaae58|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_fd5db05e-f2b2-3cd3-b10a-7e7f39c1aeff|imgt:hasClinicalIndication|imgt:Acute_myeloid_leukemia_(AML) imgt:hasTaxonRank|rdf:type|owl:AnnotationProperty imgt:IgG1-kappa-S239C_2cys-drug_866|rdfs:comment|IgG1 - kappa - S239C_2cys - drug imgt:mAb_333|rdf:type|imgt:INN imgt:mAb_508|imgt:hasMabReceptor|imgt:IgG1-kappa_MM_508 imgt:IgG1-kappa-%5BscFv%5D2-lambda_1260|rdfs:label|IgG1-kappa-[scFv]2-lambda_1260 imgt:StudyProduct_563dac3b-0d8b-31ed-b076-8a4cf3724d45|imgt:hasClinicalIndication|imgt:Solid_tumors imgt:Product_15474b50-e757-3ac8-913f-68d02e76b342|rdf:type|obo:NCIT_C51980 imgt:StudyProduct_30bb9ffe-becf-3cd4-a4cd-0a524df71a7d|imgt:hasDecision|_:Be060b92c57ce1d3a91b3291e1b40a362 imgt:StudyProduct_9eae6e66-7f22-3fb1-9cda-7d6c32e162fc|imgt:application_type|Therapeutic imgt:Product_d37750e2-ebcd-3a4a-802e-29afea0dbc7d|rdf:type|obo:NCIT_C51980 imgt:StudyProduct_52c34438-7ca7-3a7e-ba0c-4ce252b44166|imgt:isStudyProductOf|imgt:Product_e606d79d-bde1-3cc6-a544-20c1bf6683c4 imgt:mAb_997|imgt:hasOriginClone|imgt:Clone_997 imgt:Pigmented_villonodular_synovitis_(PVNS)|imgt:isClinicalIndicationOf|imgt:StudyProduct_92fa5e3e-ae62-31a2-939f-aab0c6095c4b imgt:Construct_157|imgt:hasImgtLabel|imgt:IgG1-lambda imgt:CSF3R|imgt:isTargetOf|imgt:FPIA_%5BPROTEIN%5D2-FC_980 imgt:IgG4-kappa_957|rdfs:comment|IgG4 - kappa imgt:CPCA_%5BPROTEIN_BIG%5D2-XTEN-FC_701|imgt:fused_with| Homo sapiens IGHG1 Fc (Fragment constant) imgt:mAb_1157|imgt:hasImgtStructureEntry|imgt:11590 imgt:mAb_618|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=618 imgt:StudyProduct_054e1b6c-5c9b-3a23-85f4-2725ae559110|rdfs:label|StudyProduct_054e1b6c-5c9b-3a23-85f4-2725ae559110 imgt:mAb_1257|imgt:hasMabReceptor|imgt:IgM-kappa_scFv-heavy-kappa_1257 obo:NCIT_C177059|rdfs:subClassOf|obo:NCIT_C1909 imgt:ACVR2B|rdf:type|obo:NCIT_C25702 imgt:Product_f7e1d72f-e112-32ca-932d-a29c46750710|imgt:commun_name|ZTS 00521426 imgt:Segment_696_2|imgt:hasImgtLabel|imgt:CTP_(C-terminal_peptide_of_the_β-subunit_of_human_chorionic_gonadotropin_(hCG)) imgt:hasExpressionSystem|rdfs:label|hasExpressionSystem imgt:Construct_659|imgt:hasImgtLabel|imgt:IgG4-kappa imgt:_CHO-K1|imgt:isExpressionSystemOf|imgt:StudyProduct_b99c5ced-585d-3c4f-8398-9f413b697d87 imgt:StudyProduct_d24549d2-16af-3305-88f2-6445585bd19e|imgt:hasClinicalPhase|imgt:Phase_M imgt:mAb_645|imgt:imgt_note| The sponsorship was transferred to AbbVie Deutschland GmbH & Co. KG, Germany, in May 2018. There is one amino acid difference between the H chain of 10409 losatuxizumab (10342 losatuxizumab vedotin) CH2 S3 (238) and 10960 serclutamab (10959 serclutamab talirine) due to a site-specific drug attachment engineered cysteine CH2 C3 (238) in 10960 (conjugated in 10959).There are four amino acid differences (two in the VH and two linked to allotypes) between the H chain of of 10409 losatuxizumab (10342 losatuxizumab vedotin) VH R (31), S (100), CH3 E12 (355), M14 (357) and 10262 depatuxizumab (10263 depatuxizumab mafodotin) VH S (31), G (100), CH3 D12 (355), L14 (357).The amino acid sequence of the kappa chain (1-214 AA) is identical in 10262, 10263, 10342, 10409, 10959 and 10960. imgt:Segment_983_1|rdfs:label|Segment_983_1 imgt:MAbReceptor_622|http://semanticscience.org/resource/SIO_000291|imgt:IFNAR1 imgt:IFNB1|rdf:type|obo:NCIT_C25702 imgt:10553|imgt:isImgtStructureEntryOf|imgt:mAb_757 imgt:Construct_67|imgt:hasImgtLabel|imgt:IgG1-nd imgt:mAb_453|rdf:type|imgt:INN imgt:IgG1-kappa_648|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:Clone_954|imgt:isOriginCloneOf|imgt:mAb_954 imgt:Clone_199|rdf:type|obo:NCIT_C37925 imgt:11729|rdf:type|obo:NCIT_C25402 imgt:StudyProduct_8f0ebc44-4890-3b3c-9684-6a624ba02f08|rdfs:label|StudyProduct_8f0ebc44-4890-3b3c-9684-6a624ba02f08 imgt:StudyProduct_3e9a72be-3dc1-39fb-b262-537e1e3a30f6|rdf:type|obo:NCIT_C174271 imgt:Clone_236|rdfs:label|Clone_236 imgt:mAb_462|rdf:type|imgt:INN imgt:mAb_1115|rdf:type|obo:NCIT_C174891 imgt:StudyProduct_ddfca829-8b00-399e-baed-0a1b0ac4cf92|rdf:type|obo:NCIT_C174271 imgt:mAb_776|imgt:hasMabReceptor|imgt:IgG4-kappa-%5BscFv%5D2_776 imgt:StudyProduct_2a973a1a-e37f-35eb-9dc5-08529b842cc7|rdf:type|obo:NCIT_C174271 imgt:IgG4-kappa_1066|imgt:hasMolecularComponent|imgt:IG imgt:StudyProduct_77331acd-e18f-3aac-a08e-f75df35ecae9|imgt:hasClinicalPhase|imgt:Phase_I obo:NCIT_C171828|rdfs:subClassOf|obo:NCIT_C1909 imgt:PROTEIN_1DOMAIN_917|obo:RO_0002162|imgt:Homsap imgt:Product_92aaaa11-a012-35e5-91ee-9df570fa89a7|imgt:hasStudyProduct|imgt:StudyProduct_69613c5b-ad4f-3679-a3c1-32124318d3f8 imgt:%5B(scFv-heavy-kappa)-IGHE-CH4%5D2_370|imgt:fused_with| Homo sapiens IGHE CH4, covalent dimer, radiolabelled imgt:Product_be7fe1ac-60ec-3e93-a36a-4383c0cb79ad|rdfs:label|Product_be7fe1ac-60ec-3e93-a36a-4383c0cb79ad imgt:9415|rdfs:label|9415 imgt:Clone_91|imgt:isOriginCloneOf|imgt:mAb_91 imgt:StudyProduct_0377bba3-0de4-3daa-b4c6-b3ce69e88ebd|imgt:hasClinicalIndication|imgt:Psoriasis imgt:IgG1-lambda-%5BPROTEIN%5D2_869|imgt:hasConstruct|imgt:Construct_869 imgt:mAb_602|imgt:inn_proposed_list|114 (2015) imgt:StudyProduct_c8ae31b6-988f-31d9-b3f8-d4e8e0c245ce|imgt:application_type|Therapeutic imgt:StudyProduct_9f3be9a2-1b53-3811-ab9c-570dba5a823e|imgt:isStudyProductOf|imgt:Product_a22e1e73-39c4-3d58-810c-61a5fe2f2b92 imgt:IgG1-lambda-%5BPROTEIN%5D2_869|obo:RO_0002162|imgt:Homsap imgt:Product_d1ff3524-abf9-3a7a-93d3-8b514c80da83|imgt:hasStudyProduct|imgt:StudyProduct_c3a58be7-6f2c-3796-84c1-70f8564ad24a imgt:StudyProduct_40308711-1dd3-3ca6-a40e-9d54c3600b8d|imgt:development_technology| Abgenix's XenoMouse® imgt:Construct_597|rdf:type|imgt:Construct imgt:bispecific|imgt:isTargetOf|imgt:IgM-kappa_scFv-heavy-kappa_1257 imgt:mAb_99|imgt:hasOriginClone|imgt:Clone_99 _:B6a407e496338df091af9dc7952bf9587|rdf:type|obo:NCIT_C53285 imgt:Product_9f3b70a8-1ab1-357c-82db-a284346f9860|imgt:hasStudyProduct|imgt:StudyProduct_0be86c1d-c760-383a-8925-0c1bdd77caa5 _:B21bc7b18147a0be73eb29590a6ceee9d|rdf:type|obo:NCIT_C53285 imgt:StudyProduct_608cec66-6b49-3ffc-965e-9d278f033de8|imgt:hasClinicalIndication|imgt:Allograft_rejection imgt:_CV1P_cells|rdf:type|imgt:ExpressionSystem imgt:StudyProduct_e09ced69-a82d-3408-a2f1-7c8527eafb37|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_dihydrofolate_reductase_(DHFR)_cells imgt:IgG1-kappa_336|imgt:isMabReceptorOf|imgt:mAb_336 imgt:Rabies_post-exposure|imgt:isClinicalIndicationOf|imgt:StudyProduct_71f4fd09-d853-33b8-9ad9-92de92b7befe imgt:IgG1-kappa_359|rdf:type|imgt:MAbReceptor imgt:bivalent|imgt:isTargetOf|imgt:(VH-CH2-CH3)2_S_1220 imgt:Cancers|imgt:isClinicalIndicationOf|imgt:StudyProduct_9affea31-8690-33cc-8d4b-fe899b6d0f92 imgt:Product_f4af35da-7830-3280-b962-8cc6e7f4bd35|imgt:commun_name|huS2C imgt:%5BGH1_(growth_hormone_1_somatotropin_GH_GH-N_GHN_hGH-N_pituitary_growth_hormone)%5D1-IGHG4_Fc_(Fragment_constant)|imgt:construction_detail|Fusion - [GH1 (growth hormone 1, somatotropin, GH, GH-N, GHN, hGH-N, pituitary growth hormone)]1 - IGHG4 Fc (Fragment constant) imgt:Product_dcd644d4-d907-3989-acc6-6c340412800f|rdf:type|obo:NCIT_C51980 imgt:StudyProduct_350c082b-83b8-3353-9d33-abfc733b1d61|rdf:type|obo:NCIT_C174271 imgt:F12|imgt:isTargetOf|imgt:IgG4-lambda_915 imgt:IgG1-kappa_1106|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:Segment_303_1|imgt:has_rank|1 imgt:StudyProduct_0bdd2106-00e7-3d4d-a49b-1e98b53b7596|imgt:isStudyProductOf|imgt:Product_c299e202-690b-3ffc-8c53-e45056548ad0 imgt:Construct_486|obo:BFO_0000051|imgt:Segment_486_1 imgt:IgG1-kappa_1178|rdfs:label|IgG1-kappa_1178 pubmed:21091110|dc:contributor|Oellinger R imgt:Segment_579_1|imgt:has_rank|1 imgt:IgG1-kappa_753|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:Cancers|imgt:isClinicalIndicationOf|imgt:StudyProduct_13248a2b-f29a-3472-9949-72c03414ae45 imgt:Cardiac_myxoma|imgt:isClinicalIndicationOf|imgt:StudyProduct_0756fd89-b6c2-3995-a23f-9cc99dd06136 imgt:Segment_800_1|imgt:has_rank|1 imgt:Product_e43a8019-eea8-307e-b67c-b0bd073d0380|rdfs:label|Product_e43a8019-eea8-307e-b67c-b0bd073d0380 imgt:StudyProduct_3c2f802d-354a-3caa-9d1a-424f1a8ee48d|rdfs:label|StudyProduct_3c2f802d-354a-3caa-9d1a-424f1a8ee48d imgt:MedImmune|imgt:produces|imgt:Product_15474b50-e757-3ac8-913f-68d02e76b342 imgt:1C-LIKE-1F-DOMAIN|rdfs:label|1C-LIKE-1F-DOMAIN imgt:Clone_936|rdf:type|obo:NCIT_C37925 imgt:StudyProduct_b10109da-0907-32f7-b022-043c15317a58|rdf:type|obo:NCIT_C174271 _:Bdbecb30bf22c2eec770ca7ab3a330a75|imgt:hasStatut|imgt:approval imgt:Segment_512_1|obo:BFO_0000050|imgt:Construct_512 imgt:StudyProduct_5707ebaf-6481-3026-aa43-7296288f0f4e|imgt:isStudyProductOf|imgt:Product_be4ceb56-c2c1-3a7b-90f6-a24ff96b8e20 imgt:StudyProduct_38094478-025b-385e-b251-914f5490d566|imgt:hasClinicalPhase|imgt:Phase_III imgt:Product_3f5245a0-72f1-3dc9-a7a9-7568f71c5db6|imgt:isProducedBy|imgt:Seagen_Inc_formely_Seatlle_Genetics_Inc imgt:Clone_1037|rdf:type|obo:NCIT_C37925 imgt:Clone_324|imgt:clone_name|AC10, mAC10 (IgG2b) imgt:FPIA_%5BPROTEIN_3REPEATS%5D2-3S-FC_870|imgt:hasConstruct|imgt:Construct_870 imgt:Clone_157|imgt:isOriginCloneOf|imgt:mAb_157 _:Bd8b8f90a81d001c314586a6df2767368|imgt:hasStatut|imgt:approval 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imgt:VH-VH%27-VH__trivalent_382|http://semanticscience.org/resource/SIO_000291|imgt:bispecific imgt:Product_6087ae75-1628-344c-adc7-9279223adb25|imgt:isProductOf|imgt:mAb_690 imgt:StudyProduct_3e9a72be-3dc1-39fb-b262-537e1e3a30f6|imgt:development_technology| Chimeric antigen receptor (CAR) T cell engineering imgt:IgG1-kappa-4lys-drug_387|http://semanticscience.org/resource/SIO_000291|imgt:MUC1_sialylated_carbohydrate_tumour-associated imgt:Product_91cb264b-0c51-33f5-8f57-97e282af35f0|imgt:commun_name|CNTO-95 imgt:Non-Hodgkin's_lymphoma_(NHL)|rdfs:label|Non-Hodgkin's_lymphoma_(NHL) imgt:StudyProduct_c3c0cf49-3542-3af5-97f2-1bd2997da165|imgt:isStudyProductOf|imgt:Product_6070f2ac-d903-337d-beab-a7ca53d7c933 imgt:StudyProduct_8b2e4e04-64d3-32a1-9c3e-b0f965cb7b77|imgt:application_type|Therapeutic imgt:Cytune_Pharma_SAS|rdfs:label|Cytune Pharma SAS imgt:StudyProduct_a209289d-05ee-34a5-9eef-2f615f32282f|imgt:hasClinicalIndication|imgt:Progressive_supranuclear_palsy_(PSP) 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imgt:StudyProduct_3c2f802d-354a-3caa-9d1a-424f1a8ee48d|imgt:hasDecision|_:B568e48a04566299ced21010bb4cb20ea imgt:Product_ac4bd0ed-460f-34fb-8dc2-a259a562ee2f|rdfs:label|Product_ac4bd0ed-460f-34fb-8dc2-a259a562ee2f imgt:mAb_681|rdfs:label|mAb_681 imgt:Pieris_Pharmaceuticals_Inc|imgt:produces|imgt:Product_4de55e77-7186-39d1-bc82-1a6d21e0c87a pubmed:16699037|dc:contributor|Ami Y imgt:Product_bc514448-4d9c-3d80-8e18-14a8a87cb199|rdfs:label|Product_bc514448-4d9c-3d80-8e18-14a8a87cb199 _:Be0bdf5dade1d2f2e0f211d7255deded4|dc:date|2017-08-03 imgt:mAb_453|imgt:hasMabReceptor|imgt:IgG1-kappa_453 imgt:StudyProduct_e2f142a9-d738-374b-9de3-f9212eca3c7b|rdf:type|obo:NCIT_C174271 imgt:Segment_416_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Product_a5c1a1b9-506a-361d-a62c-eee6f10d449a|imgt:isProducedBy|imgt:Genrix_(Shanghai)_Biopharmaceutical imgt:IgG1-nd_445|imgt:hasConstruct|imgt:Construct_445 imgt:Construct_769|imgt:isConstructOf|imgt:IgG1-kappa_769 obo:RO_0001019|rdfs:label|contains imgt:isSegmentOf|owl:inverseOf|imgt:hasSegment obo:NCIT_C166723|rdfs:subClassOf|obo:NCIT_C1909 imgt:mAb_71|imgt:inn_recommended_list|49 (2003) imgt:StudyProduct_db545417-635e-3438-a88d-54bebe760e5b|rdfs:label|StudyProduct_db545417-635e-3438-a88d-54bebe760e5b imgt:IgG4-lambda_1031|http://semanticscience.org/resource/SIO_000291|imgt:CD274 imgt:Construct_846|imgt:hasImgtLabel|imgt:IgG4-kappa imgt:StudyProduct_ae30a3d1-32c8-3507-8e00-744436441b55|imgt:application_type|Therapeutic imgt:Product_b0734cf2-486f-3853-a05a-854676784ad9|rdfs:label|Product_b0734cf2-486f-3853-a05a-854676784ad9 pubmed:7719381|imgt:isBibliographicReferenceOf|imgt:mAb_186 imgt:Clone_50|rdf:type|obo:NCIT_C37925 imgt:TGM2|skos:definition|TGM2 (transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)) imgt:CD3E|imgt:isTargetOf|imgt:scFv-scFv-scFc_kappa-lambda_1192 imgt:mAb_125|rdf:type|obo:NCIT_C1909 imgt:IgG1-kappa_937|rdfs:label|IgG1-kappa_937 imgt:IgG2a-nd_303|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG2a-nd.png imgt:IgG2-kappa_1202|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG2-kappa.png imgt:mAb_394|imgt:clinical_trials|70 studies found, 13 recruiting imgt:Segment_238_1|rdfs:label|Segment_238_1 imgt:IgG2-kappa_1064|imgt:isMabReceptorOf|imgt:mAb_1064 imgt:Construct_755|imgt:isConstructOf|imgt:IgG2-kappa_755 imgt:Lewis_Y|imgt:isTargetOf|imgt:IgG1-kappa_150 imgt:Construct_1026|rdf:type|imgt:Construct imgt:Construct_824|rdf:type|imgt:Construct imgt:StudyProduct_2d924b80-9cd2-391c-9954-1ac1206ab109|rdf:type|obo:NCIT_C174271 obo:NCIT_C152308|rdf:type|owl:Class imgt:CPCA_PEPTIDE-PEG-FC_673|imgt:isMabReceptorOf|imgt:mAb_673 _:Bc281816125dbb9a20b5ac2bde3b14adb|dc:date|2004-02-12 imgt:Product_7cb16819-b6f9-3a3b-9d36-96c6bc96c1e3|imgt:commun_name|burosumab-twz imgt:StudyProduct_81927165-cf24-379f-bd6f-871335b30244|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_6b12cc8b-fb90-35c4-9c2b-37dcf5c052cd|imgt:hasClinicalIndication|imgt:reversal_of_the_antiplatelet_effects_of_ticagrelor_(BRILINTA®_a_blood_thinner_platelet_aggregation_inhibitor) obo:NCIT_C91701|rdf:type|owl:Class imgt:11961|imgt:isImgtStructureEntryOf|imgt:mAb_1213 obo:NCIT_C129876|rdfs:subClassOf|obo:NCIT_C1909 imgt:StudyProduct_6bde1980-495c-3cc6-ad93-882c2bb2a125|rdf:type|obo:NCIT_C174271 imgt:CARRIER_BIG-PROTEIN_1DOMAIN_692|imgt:hasConstruct|imgt:Construct_692 imgt:TR-BETA-1|rdfs:label|TR-BETA-1 imgt:Product_29ed30a2-7708-3212-b64a-672c17f2dab4|rdf:type|obo:NCIT_C51980 imgt:MedImmune|imgt:produces|imgt:Product_2ca07176-627f-3036-8c58-f334a3ca5f13 imgt:StudyProduct_20dbabaf-a025-3fd3-bef3-5e97636822b4|imgt:development_technology| Chimeric antigen receptor (CAR) T cell engineering imgt:mAb_97|imgt:hasMabReceptor|imgt:IgG1-kappa_97 imgt:Construct_62|imgt:isConstructOf|imgt:MAbReceptor_62 imgt:Hypoglycemia|imgt:isClinicalIndicationOf|imgt:StudyProduct_07804ddb-b8d6-31df-9157-36557c4b7b62 imgt:Segment_1226_1|imgt:hasImgtLabel|imgt:F(ab)2-G1-kappa imgt:Product_4a4c4d40-304a-3d8a-bef8-533a579b445d|imgt:hasStudyProduct|imgt:StudyProduct_39359382-d6a3-3bf2-8542-36e74e7e9da8 imgt:mAb_726|imgt:hasProduct|imgt:Product_01aa0fdc-6298-3406-8d85-80c740496dd1 imgt:Clone_1150|rdf:type|obo:NCIT_C37925 imgt:StudyProduct_1d99192d-4b8f-35ef-bd0b-fa72bd86cd18|imgt:application_type|Therapeutic imgt:mAb_174|imgt:hasProduct|imgt:Product_f270708b-487c-329b-bc7f-75ae0b3961a1 imgt:StudyProduct_3a7dd7dc-6fce-3439-bd80-027118fb5829|imgt:application_type|Therapeutic _:B55195c0b9ca8ebd0642d43c323f4a646|dc:date|2021-03-04 imgt:FR1|skos:definition|first framework imgt:mAb_84|imgt:clinical_trials|586 studies found, 22 recruiting _:B10757571172ae21ea79a1c9c76de165b|dc:date|2017-09-01 imgt:Cardiopulmonary_bypass_(CPB)|rdfs:label|Cardiopulmonary_bypass_(CPB) imgt:Product_e5ce155e-e05d-3dfc-93a5-26bc31a1072c|rdf:type|obo:NCIT_C51980 obo:NCIT_C169865|rdf:type|owl:Class imgt:is_completed|rdf:type|owl:DatatypeProperty imgt:StudyProduct_0d3679a4-268c-3d34-b93d-442ddd27af84|imgt:hasClinicalPhase|imgt:Preclinical pubmed:7688398|dc:contributor|Sims M.J. imgt:IgG1-kappa_349|rdfs:label|IgG1-kappa_349 imgt:MASP2|skos:definition|MASP2 (mannan-binding lectin serine peptidase 1 pseudogene 1, mannan-binding lectin serine protease 1 pseudogene 1, mannan-binding lectin serine protease 2, MASP1P1) imgt:mAb_313|imgt:imgt_note| The same name ‘Specifid’ was used for patient-specific immunotherapy with mitumprotimut-T (idiotype keyhole limpet hemocyanin [Id-KLH]) formerly FavId®, by Favrille, Inc. (San Diego), in a phase III clinical trial for vaccine in Non-Hodgkin's lymphoma. imgt:Fab%27-G1-nd_139|rdfs:comment|Fab' - G1 - nd imgt:Construct_1074|imgt:isConstructOf|imgt:scFv-scFv-scFc_kappa-lambda_1074 obo:NCIT_C48426|rdf:type|owl:Class imgt:StudyProduct_9f557969-ab56-3ded-bc53-cb04c365c2b3|imgt:hasClinicalPhase|imgt:Phase_M imgt:mAb_46|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=46 _:B64e681c19649b7dc1faf4a9fd2dcd0c6|imgt:isDecisionOf|imgt:StudyProduct_c398d23a-1697-3b9d-be1d-6684184d1772 imgt:Product_d162eac6-223f-3784-93c7-8637ba2b95cc|imgt:commun_name|rhuMab HER2 obo:NCIT_C126113|rdfs:subClassOf|obo:NCIT_C1909 imgt:F(ab’)2-Gamma-2-c_Kappa|rdf:type|imgt:ReceptorType imgt:Segment_1091_1|obo:BFO_0000050|imgt:Construct_1091 imgt:IL13|obo:RO_0002162|imgt:Homsap imgt:StudyProduct_61dc3c81-aee9-350f-8e30-60af5dc8b9a2|imgt:development_technology| Dyax human antibody phage display library imgt:StudyProduct_1ba64066-4a99-3e7e-b455-83858d45f09f|imgt:hasClinicalPhase|imgt:Phase_M _:Bd0805274aefefc34dfd4419752e8b7e2|dc:date|2016-01-11 imgt:mAb_1205|imgt:hasProduct|imgt:Product_db84ae4e-9412-31fc-857b-080465955a1f imgt:mAb_225|rdf:type|obo:NCIT_C95024 imgt:IgG1-Fab-kappa-lambda_1286|imgt:hasMolecularComponent|imgt:IG imgt:IgG4-lambda2_335|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG4-lambda2.png _:B53fc959bb30e419b52bb1fabad393937|imgt:isDecisionOf|imgt:StudyProduct_81683a1e-9f05-3c20-9ce5-1795547f315b imgt:Product_b4ab3c62-24b2-3d64-b784-2e7b8f08aeb2|imgt:isProducedBy|imgt:Janssen_Biotech_Inc imgt:StudyProduct_2f0de076-c4a6-3476-ae32-fde30947f64d|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:mAb_5|imgt:hasOriginClone|imgt:Clone_5 imgt:Rabies_post-exposure|imgt:clinical_domain|Infectiology imgt:Alternative_to_antigen_receptors_(domain_scaffold:_TNC-F3_tenascin_domain_F3)|rdf:type|imgt:SegmentLabels imgt:Product_77016dda-c72a-3c2b-a774-67ee29fc1930|rdf:type|obo:NCIT_C51980 imgt:IgG1-kappa-S239C_2cys-drug_904|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa-S239C_2cys-drug.png imgt:Product_a8e7144e-8be0-3481-a89b-994c08a8e5d0|imgt:commun_name|UB 421 imgt:11038|imgt:isImgtStructureEntryOf|imgt:mAb_947 imgt:IgG1-lambda_1172|http://semanticscience.org/resource/SIO_000291|imgt:CD274 imgt:Segment_118_1|rdfs:label|Segment_118_1 imgt:Product_db8d8267-f336-3715-b038-38454987d7a7|imgt:hasStudyProduct|imgt:StudyProduct_db8d8267-f336-3715-b038-38454987d7a7 imgt:mAb_247|imgt:hasMabReceptor|imgt:FPIA_%5BPROTEIN_VLIKE%5D2-1S-FC_247 imgt:H-GAMMA-1-C-KAPPA|skos:definition|Chain comprising a H-GAMMA-1 and a C-KAPPA domains imgt:MH2-ALPHA_PEPTIDE-BETA|skos:definition|MH receptor comprising one II-ALPHA and II-BETA chains with a covalently linked peptide imgt:Product_9e85a06f-cc89-31ca-b689-1be2820b0536|imgt:hasStudyProduct|imgt:StudyProduct_a779018f-4c09-321d-a9a5-bcd91e3cf91f imgt:Crucell|rdfs:comment|CN Leiden , Netherlands imgt:Pseudomonas_aeruginosa_hospital_acquired_pneumonia_caused_by_serotype_011_positive_Pseudomonas_aeruginosa|imgt:clinical_domain|Infectiology imgt:PEPTIDE-II-ALPHA|rdfs:label|PEPTIDE-II-ALPHA imgt:Construct_1264|rdfs:label|Construct_1264 imgt:StudyProduct_521bdb6c-241f-3c8b-83bf-6f87a696275a|imgt:application_type|Therapeutic imgt:StudyProduct_4495f259-8824-3877-b42f-dde6cabec1b7|imgt:hasExpressionSystem|imgt:_CHO-K1 imgt:mAb_954|imgt:inn_number|11055 imgt:Construct_870|obo:BFO_0000051|imgt:Segment_870_2 imgt:1C-LIKE-1F-DOMAIN|rdf:type|imgt:RPILabel imgt:IgG1-kappa_518|http://semanticscience.org/resource/SIO_000291|imgt:CD19 imgt:IgG2-kappa-4cys-drug_565|imgt:via_a| cleavable maleimidocaproyl-valyl-citrullinyl-p-aminobenzyloxycarbonyl (mc-val-cit-PABC) type linker imgt:Establishment_of_immunological_tolerance_state|rdfs:label|Establishment_of_immunological_tolerance_state imgt:Product_54f209d7-05c3-3ff2-85c3-85c48ac1eef4|rdfs:label|Product_54f209d7-05c3-3ff2-85c3-85c48ac1eef4 imgt:StudyProduct_5e6c4745-516f-3e95-aaa1-77d6b958b6d1|imgt:hasClinicalPhase|imgt:Phase_III imgt:IgG/A|rdfs:label|IgG / A imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_a8e8e872-ce06-325d-bfd3-06fc7a1561b1 imgt:Taxon|dc:identifier|imgt_000328 imgt:Product_bf01e52c-681c-3e27-a65a-7e56b7753697|imgt:isProductOf|imgt:mAb_468 imgt:Segment_703_2|imgt:has_rank|2 imgt:_CHO-S_(Chinese_Hamster_Ovary)_cells_suspension_culture|imgt:isExpressionSystemOf|imgt:StudyProduct_3c2f61fd-a181-3f7a-89d4-514b329385c0 imgt:IgG1-kappa_359|imgt:hasMolecularComponent|imgt:IG imgt:StudyProduct_b231ce81-6a69-397a-8c71-3a20fac3d2ca|imgt:hasClinicalPhase|imgt:Phase_M imgt:CD40LG|imgt:isTargetOf|imgt:IgG1-kappa_17 imgt:Product_f0d92412-c496-3d57-9a98-563e17652865|imgt:hasStudyProduct|imgt:StudyProduct_2f0de076-c4a6-3476-ae32-fde30947f64d imgt:Product_fab71c13-636a-3dfa-afb9-5d876481d738|imgt:hasStudyProduct|imgt:StudyProduct_6cf579af-269c-3fad-8055-33d54d657d07 imgt:Construct_783|rdfs:label|Construct_783 imgt:Renal_cell_carcinoma_(RCC)|imgt:isClinicalIndicationOf|imgt:StudyProduct_ed73ac65-2f5f-357d-a8b1-f0747a0370d4 imgt:StudyProduct_08b9cb90-6d16-3be4-9762-c96c5f4f1501|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:Construct_928|rdfs:label|Construct_928 imgt:mAb_745|imgt:hasMabReceptor|imgt:ELP-PEPTIDE_745 imgt:mAb_722|rdf:type|obo:NCIT_C128799 imgt:IgG4-kappa_174|imgt:isMabReceptorOf|imgt:mAb_174 imgt:Product_14914095-c8ee-3cb4-877f-013fc6ba8589|imgt:hasStudyProduct|imgt:StudyProduct_1af43e04-84b8-36dd-8505-b9366b9f6895 imgt:Construct_355|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:StudyProduct_8889d288-1776-3c68-a627-317a34dc1c95|imgt:isStudyProductOf|imgt:Product_02dd533d-4a92-33f2-bf63-c8a37a8c980f imgt:mAb_988|rdf:type|obo:NCIT_C1909 imgt:Momenta_Pharmaceuticals_Inc|rdfs:label|Momenta Pharmaceuticals, Inc. imgt:Construct_695|rdfs:label|Construct_695 imgt:10661|imgt:isImgtStructureEntryOf|imgt:mAb_872 imgt:Product_d6661c7d-81b0-3c2b-8328-9a7b5dfcae38|imgt:hasStudyProduct|imgt:StudyProduct_f8e070f0-9178-373d-9d81-ffb46c539e03 imgt:mAb_702|rdf:type|obo:NCIT_C1909 imgt:mAb_521|imgt:hasProduct|imgt:Product_dc2a0795-349d-373b-be05-d16cf2186843 imgt:FPIA_%5BPROTEIN_1REPEAT%5D2-FC_246|imgt:fused_with| Homo sapiens IGHG1 Fc (Fragment constant) imgt:mAb_413|imgt:inn_recommended_list|69 (2013) imgt:mAb_180|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=180 imgt:MacroGenics_Inc|rdf:type|obo:NCIT_C54131 imgt:EGFR|rdfs:label|EGFR imgt:Construct_925|imgt:isConstructOf|imgt:IgG1-kappa_925 imgt:IgG1-kappa-4cys-drug_896|http://semanticscience.org/resource/SIO_000291|imgt:ERBB2 imgt:Acute_atypical_appendicitis|rdfs:label|Acute_atypical_appendicitis imgt:CDR2-IMGT|rdfs:label|CDR2-IMGT imgt:Cancers_breast|imgt:isClinicalIndicationOf|imgt:StudyProduct_dd88f5dd-8d77-3766-9219-118b017a5fe6 imgt:H-CH2-CH3|skos:definition|Chain comprising HINGE, CH2 and CH3 domains imgt:mAb_1241|rdf:type|obo:NCIT_C1909 imgt:mAb_519|imgt:inn_name|lacutamab imgt:L-IOTA-4|rdfs:label|L-IOTA-4 imgt:StudyProduct_bfc8cbce-1b77-3bf1-aff0-90fb23bb56ec|imgt:hasDecision|_:B1abe5579892852cf7f165a8d999c22e9 _:Ba589973be2c924472bd0e3bf1dd17e3a|imgt:isDecidedBy|imgt:FDA imgt:Construct_870|imgt:hasImgtLabel|imgt:%5BHomo_sapiens_TNFSF10_(TNF_superfamily_member_10_tumor_necrosis_factor_(ligand)_superfamily_member_10)%5D2-Homo_sapiens_IGHG1_Fc_(Fragment_constant) https://doi.org/10.1016/0141-8130(95)93516-Z|dc:contributor|Harris W.J. _:B17d518dbbbf5302be8e29aac877f583b|imgt:isDecisionOf|imgt:StudyProduct_1d4aa306-6821-3719-8f13-e1bab47134c8 imgt:11526|rdfs:label|11526 imgt:Product_785b96d0-9949-370c-8ff7-5e6014018922|imgt:commun_name|HU-901 imgt:StudyProduct_2cfb22ab-99b7-32af-b122-5f8019aef21e|imgt:isStudyProductOf|imgt:Product_7059201d-e2a8-3adc-9d1e-93b8e0e1285d imgt:mAb_1032|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=1032 obo:NCIT_C175823|rdf:type|owl:Class imgt:IgG1-kappa_1106|imgt:isMabReceptorOf|imgt:mAb_1106 imgt:StudyProduct_105a4697-29fc-3299-83ce-6af63d477662|imgt:isStudyProductOf|imgt:Product_e74c938c-d5ce-32f7-80c4-b52d9dfc9789 imgt:V-NONAMER|rdfs:label|V-NONAMER imgt:Construct_541|rdf:type|imgt:Construct imgt:Construct_1135|imgt:hasImgtLabel|imgt:IgG4-kappa imgt:_NS0_mouse_myeloma_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_773868e5-eff6-3aac-a866-62bdf844a898 imgt:StudyProduct_81261019-21ab-3bac-a3a4-0485831c5aa8|imgt:application_type|Therapeutic obo:NCIT_C116747|rdf:type|owl:Class imgt:Segment_1206_1|rdfs:label|Segment_1206_1 imgt:Product_35874c60-bbc8-3078-95f7-d5da364ab3b8|imgt:commun_name|18F1 imgt:IgG1-kappa_1195|obo:RO_0002162|imgt:Hum imgt:StudyProduct_94c0040f-b4c8-3e29-9d30-5d34c53c3c22|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:IgG1-kappa_857|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:Product_56f1d246-c576-3e7e-a937-8f3bc41ecd9e|rdfs:label|Product_56f1d246-c576-3e7e-a937-8f3bc41ecd9e imgt:Product_77016dda-c72a-3c2b-a774-67ee29fc1930|imgt:isProducedBy|imgt:NeuTec_Pharma_plc imgt:Product_a4d4a5e8-f868-388c-87fe-5d2336f3206d|imgt:commun_name|Xmab5574 imgt:IgG1-kappa_841|rdf:type|imgt:MAbReceptor imgt:IgG1-kappa_653|obo:RO_0002162|imgt:Hum obo:NCIT_C170293|rdf:type|owl:Class imgt:Construct_262|rdfs:label|Construct_262 imgt:IG-MU_KAPPA_J-CHAIN|rdf:type|imgt:StructureLabels imgt:mAb_696|imgt:inn_proposed_list|80 (1998) imgt:IgG1-kappa_1012|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:mAb_1112|imgt:inn_name|zansecimab imgt:Construct_984|rdf:type|imgt:Construct imgt:mAb_1099|imgt:hasImgtStructureEntry|imgt:11372 _:Ba9ddca18fc9d8b99ae85dca7254b7bd6|imgt:hasStatut|imgt:approval imgt:StudyProduct_0bf6eb3e-ae1f-3211-b64b-2e4f87af2cee|imgt:application_type|Therapeutic imgt:mAb_1134|imgt:hasProduct|imgt:Product_bd756867-c2d7-332c-8078-ce332c14176d imgt:Transplant_rejection|rdf:type|obo:NCIT_C185637 imgt:IgG1-nd_40|obo:RO_0002162|imgt:Hum _:Bc80c117f669475494baed3dce1061559|imgt:isDecisionOf|imgt:StudyProduct_c344ff5c-cd56-36b9-95c9-d727c1fd324d imgt:mAb_380|imgt:clinical_trials|43 studies found, 8 recruiting imgt:Segment_556_1|rdfs:label|Segment_556_1 imgt:Product_8bd206f8-aceb-33f2-82ee-f4b3427759f5|imgt:commun_name|CAM-3001 imgt:mAb_777|imgt:inn_proposed_list|117 (2017) imgt:mAb_378|rdfs:label|mAb_378 imgt:IgG4-kappa_898|imgt:hasMolecularComponent|imgt:IG imgt:_CHOK1SV_(expresses_glutamine_synthetase_(GS)_endogenously)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_ebae25c4-1751-3f03-935f-833a3a2334c3 imgt:Product_a49e9411-d64f-353e-8cfd-d09ad10a15b3|rdf:type|obo:NCIT_C51980 imgt:FPIA_%5BPROTEIN%5D2-FC_475|http://semanticscience.org/resource/SIO_000291|imgt:Wnt_ligands imgt:mAb_1281|imgt:inn_number|11904 imgt:Fab%27-G1-nd_139|obo:RO_0002162|imgt:Musmus imgt:mAb_972|imgt:inn_number|11061 imgt:Product_46489dd5-dbbb-3ac3-a0f1-64d45c1d847d|rdfs:label|Product_46489dd5-dbbb-3ac3-a0f1-64d45c1d847d imgt:Construct_1010|obo:BFO_0000051|imgt:Segment_1010_1 imgt:Product_5038f9ea-65d4-3eb8-b074-e25dab59e6c5|imgt:commun_name|M4 imgt:Segment_1294_1|imgt:has_rank|1 imgt:Inflammatory_lesions|imgt:clinical_domain|Immunology imgt:StudyProduct_c9cb9aa6-0e00-3387-9b2f-cf4c47721430|rdfs:label|StudyProduct_c9cb9aa6-0e00-3387-9b2f-cf4c47721430 imgt:Adrenomed_AG|rdfs:label|Adrenomed AG imgt:Construct_1115|rdfs:label|Construct_1115 imgt:IL22RA1|obo:RO_0002162|imgt:Homsap imgt:StudyProduct_d2433268-2582-3566-bb16-4c56a6262e4c|imgt:development_technology| Dual-Affinity Re-targenting (DART®) imgt:mAb_262|imgt:hasBibliographicReference|pubmed:10960454 imgt:Segment_702_1|rdf:type|imgt:Segment obo:NCIT_C185637|skos:definition|Signs and/or symptoms leading a practitioner to recommend a particular clinical intervention. imgt:Clone_1135|rdfs:label|Clone_1135 imgt:_CHO-K1|imgt:isExpressionSystemOf|imgt:StudyProduct_e71f82cd-4d55-3f0e-bac1-74d5fa41efb3 imgt:Construct_13|rdf:type|imgt:Construct imgt:Product_6d00b4b8-121c-3156-854d-ae9f08aba45a|rdf:type|obo:NCIT_C51980 imgt:FUSION-%5BTNFRSF13B%5D2-FC-GAMMA-1|rdf:type|imgt:FPIALabel imgt:mAb_631|imgt:hasBiosimilar|imgt:grastofil imgt:variable_lymphocyte_receptor|rdfs:label|variable_lymphocyte_receptor imgt:IgG1-kappa_928|rdfs:comment|IgG1 - kappa imgt:StudyProduct_c2507d13-5072-352d-a3f4-c24fbcd25830|rdfs:label|StudyProduct_c2507d13-5072-352d-a3f4-c24fbcd25830 _:B0a8ad01c9dd5f399595bcb35aace5563|imgt:isDecidedBy|imgt:FDA imgt:scFv-heavy-kappa_173|imgt:isMabReceptorOf|imgt:mAb_173 imgt:Product_4a302c39-2f94-36f4-92b1-fd214b3ec5d3|imgt:hasStudyProduct|imgt:StudyProduct_6159ba4f-4996-34de-843a-75de55eb9a82 imgt:TR-GAMMA_DELTA|rdfs:label|TR-GAMMA_DELTA imgt:Fab-nd-nd_320|imgt:isMabReceptorOf|imgt:mAb_320 imgt:Construct_385|obo:BFO_0000051|imgt:Segment_385_1 imgt:IgG1-lambda_800|obo:RO_0002162|imgt:Homsap imgt:Construct_609|obo:BFO_0000051|imgt:Segment_609_1 imgt:Construct_966|obo:BFO_0000051|imgt:Segment_966_1 imgt:FAB-ALPHA_LAMBDA|rdf:type|imgt:StructureLabels imgt:IgG1-kappa_383|http://semanticscience.org/resource/SIO_000291|imgt:LTA imgt:Product_7e295705-2be2-3155-abb4-bbd44acfd06b|imgt:commun_name|MDX-CD4 imgt:StudyProduct_e71f82cd-4d55-3f0e-bac1-74d5fa41efb3|rdf:type|obo:NCIT_C174271 imgt:mAb_70|imgt:hasProduct|imgt:Product_14bc3b7e-30da-3723-af19-76b738f8473b imgt:Cancers_non-small_cell_lung_(NSCLC)|imgt:isClinicalIndicationOf|imgt:StudyProduct_80b6bae5-6806-3ea3-9165-3cff6fbac3e8 imgt:mAb_1062|rdf:type|obo:NCIT_C175797 imgt:Anaplastic_large_cell_lymphoma_(ALCL)|imgt:isClinicalIndicationOf|imgt:StudyProduct_e2525ede-6e14-3230-8bb4-d37055d1792e pubmed:1367535|imgt:isBibliographicReferenceOf|imgt:mAb_85 imgt:_PER.C6®|imgt:isExpressionSystemOf|imgt:StudyProduct_5cd87dea-34f0-34e4-97ea-af0982f08b31 imgt:StudyProduct_2ad9d678-26a3-3db3-bc03-8bc7cb226cac|imgt:development_technology| True Human™ antibody discovery platform imgt:StudyProduct_6351a5c3-2fce-352f-baa0-4c066998dad7|rdfs:label|StudyProduct_6351a5c3-2fce-352f-baa0-4c066998dad7 obo:NCIT_C1476|rdfs:subClassOf|obo:NCIT_C1909 imgt:mAb_244|imgt:imgt_note| Medarex was acquired by Bristol Myers Squibb in 2009. Medarex’s UltiMAb Human Antibody Development System®, uses transgenic mice, specifically Medarex’s HuMAb-Mouse®, Kirin Brewing Co., Ltd’s TC Mouse and the KM-Mouse, a hybrid of the former two mice. imgt:Product_07a0f8df-d456-3179-a3a2-ab802e7d3e13|rdfs:label|Product_07a0f8df-d456-3179-a3a2-ab802e7d3e13 imgt:Anemia_in_chronic_kidney_disease-related_(CKD)|imgt:isClinicalIndicationOf|imgt:StudyProduct_d33d64b5-0bc8-3616-8a84-7afbb5771141 imgt:StudyProduct_39a07acf-358e-3f3a-825b-9ea75267ff72|imgt:application_type|Therapeutic imgt:IgG1-lambda-kappa(2)_1119|rdfs:comment|IgG1-lambda-kappa(2) imgt:StudyProduct_1200f9cf-8825-34f4-abe8-7b78c6049249|rdf:type|obo:NCIT_C174271 obo:NCIT_C174794|rdf:type|owl:Class imgt:Crohn's_disease_(CD)|imgt:isClinicalIndicationOf|imgt:StudyProduct_2d5059b6-37f9-3010-ac29-2c55c015be33 imgt:Biotie_Therapies_Corp|rdf:type|obo:NCIT_C54131 imgt:T_cell_malignancies|imgt:isClinicalIndicationOf|imgt:StudyProduct_0b960111-911b-397c-80ea-abee4766eb34 imgt:C-ALPHA|rdf:type|imgt:C-DomainLabel obo:GENO_0000413|rdfs:domain|imgt:Gene imgt:Clone_269|obo:RO_0002162|imgt:Musmus imgt:F(ab%27)2-G3-kappa|imgt:construction_detail|F(ab')2 - G3 - kappa imgt:Fab-Gamma-2-b_Lambda|imgt:isDefinedBy|imgt:IG-Heavy-Gamma-2-b-IGHG2B pubmed:8095956|dc:date|1993 imgt:IgG1-kappa_720|obo:RO_0002162|imgt:Chi imgt:V-D-J-C-chain|rdf:type|imgt:Molecule_EntityType imgt:mAb_204|imgt:hasMabReceptor|imgt:MAbReceptor_204 imgt:MAbReceptor_995|rdf:type|imgt:MAbReceptor imgt:IgG1-kappa_756|rdfs:comment|IgG1 - kappa imgt:F(ab’)2-Delta_Kappa|imgt:isDescribedBy|imgt:F(AB')2-DELTA_KAPPA imgt:Clone_1283|obo:RO_0002162|imgt:Musmus imgt:Clone_559|rdf:type|obo:NCIT_C37925 imgt:Clone_188|imgt:isOriginCloneOf|imgt:mAb_188 imgt:Clone_668|rdf:type|obo:NCIT_C37925 imgt:IgG4-kappa_44|rdfs:label|IgG4-kappa_44 imgt:Segment_805_1|rdfs:label|Segment_805_1 imgt:Product_285bd500-f170-3f00-920a-d6ab36e76e9a|rdf:type|obo:NCIT_C51980 imgt:Product_b7bee7b5-34bb-3282-9b4f-2678b12b5b39|imgt:isProductOf|imgt:mAb_117 imgt:Acute_myeloid_leukemia_(AML)|imgt:isClinicalIndicationOf|imgt:StudyProduct_cdf5fba6-10d2-34ab-b4c5-8dbb22a4fef8 imgt:CD3E|imgt:isTargetOf|imgt:V-kappa-VH-V-lambda-VH%27_tandAb_1152 pubmed:648586|dc:date|1978 imgt:Segment_488_1|rdfs:label|Segment_488_1 imgt:Inflammatory_diseases|imgt:isClinicalIndicationOf|imgt:StudyProduct_6da5c90c-7d49-340d-89f5-e40e28b71aea imgt:mAb_1202|imgt:hasOriginClone|imgt:Clone_1202 _:Bea4461d890dad0a49529337d08fe84fc|rdf:type|obo:NCIT_C53285 imgt:chicken_lysosyme|skos:definition|chicken lysosyme imgt:Gene|rdf:type|owl:Class imgt:StudyProduct_29e29167-dc73-34ac-b630-75a3d01a0d0e|imgt:hasClinicalIndication|imgt:Type_2_diabetes_(T2_DM) imgt:Product_22e71cb5-4fe7-3627-8a07-360ee7654a02|imgt:isProductOf|imgt:mAb_681 imgt:MAbReceptor_181|imgt:isMabReceptorOf|imgt:mAb_181 imgt:StudyProduct_e8b0cc56-aea9-3ccc-bbb1-8e9b24c3570f|rdfs:label|StudyProduct_e8b0cc56-aea9-3ccc-bbb1-8e9b24c3570f obo:NCIT_C79569|rdf:type|owl:Class imgt:Product_20f07591-c6fc-3220-bfe6-37cda29bb3f6|imgt:hasStudyProduct|imgt:StudyProduct_20f07591-c6fc-3220-bfe6-37cda29bb3f6 imgt:scFv-scFv-scFc_kappa-lambda_1055|http://semanticscience.org/resource/SIO_000291|imgt:CD33 imgt:StudyProduct_6c69d297-598c-3cb2-b7fa-307a30984358|rdfs:label|StudyProduct_6c69d297-598c-3cb2-b7fa-307a30984358 imgt:Construct_1036|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Massachusetts_Biologic_Laboratories|rdfs:label|Massachusetts Biologic Laboratories imgt:StudyProduct_70b9a532-ec91-3494-b50f-e40c7adaae58|imgt:application_type|Therapeutic imgt:VH|imgt:construction_detail|VH imgt:Cancers_endometrial_(EC)|imgt:isClinicalIndicationOf|imgt:StudyProduct_93dd0dc0-9322-3b0b-b887-8fbf2be423cd imgt:Solid_tumors|imgt:isClinicalIndicationOf|imgt:StudyProduct_08184582-b131-3764-92a2-abfde04a4586 imgt:mAb_11|imgt:hasBibliographicReference|pubmed:21091110 imgt:StudyProduct_aae454ab-ebb6-3ed9-9d8e-cbe255693209|rdfs:label|StudyProduct_aae454ab-ebb6-3ed9-9d8e-cbe255693209 imgt:grastofil|imgt:isBiosimilarOf|imgt:mAb_631 _:B70a187752a81df36925ddb0292913c6b|imgt:isDecidedBy|imgt:FDA _:B30129f331b9e8f99c6fbfe00339205e1|imgt:hasStatut|imgt:approval imgt:mAb_863|imgt:clinical_trials|123 studies found, 110 recruiting imgt:StudyProduct_c6f69dbf-6f7d-321e-957f-95fea16b4b17|imgt:hasClinicalPhase|imgt:Phase_M imgt:Construct_685|imgt:isConstructOf|imgt:CARRIER_BIG-PROTEIN_1DOMAIN_685 imgt:Product_dfe835ee-5c5b-301c-9664-637ed6a8128c|imgt:hasStudyProduct|imgt:StudyProduct_26e3d6fe-21a9-346c-aec2-a42a0df1ec22 imgt:FAB-GAMMA-2C_KAPPA|rdfs:label|FAB-GAMMA-2C_KAPPA imgt:StudyProduct_92fa5e3e-ae62-31a2-939f-aab0c6095c4b|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:IgG4-lambda_152|obo:RO_0002162|imgt:Chi _:Bde72025626b3729c3542aafedce82d63|imgt:isDecidedBy|imgt:FDA imgt:Segment_149_1|imgt:hasImgtLabel|imgt:IgG1-kappa obo:NCIT_C184860|rdfs:subClassOf|obo:NCIT_C1909 _:Bb2429c6ca616cb6226067307ae0f654e|rdf:type|obo:NCIT_C53285 imgt:Segment_282_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Construct_25|rdf:type|imgt:Construct imgt:mAb_626|imgt:hasProduct|imgt:Product_c7cf4dec-df13-33c9-9a7e-798c0993539c imgt:StudyProduct_ef08ffd3-2cf6-3dcc-ac77-1e5b45a034ca|imgt:development_technology| Medarex’s UltiMAb® imgt:%5BscFv-kappa-heavy-PROT%5D3_797|http://semanticscience.org/resource/SIO_000291|imgt:FN_(fibronectin) imgt:mAb_923|rdfs:label|mAb_923 imgt:D-J-C-transcript|protege:protege#subclassesDisjoint|true imgt:mAb_224|imgt:hasMabReceptor|imgt:IgG1-kappa_224 imgt:mAb_214|imgt:hasMabReceptor|imgt:FPIA_%5BPROTEIN-PROTEIN%5D2-FC_214 imgt:mAb_282|rdf:type|imgt:INN imgt:IgG1-kappa_750|obo:RO_0002162|imgt:Chi imgt:StudyProduct_3b978335-3ad0-3d4d-be6b-4bd94a891758|rdfs:label|StudyProduct_3b978335-3ad0-3d4d-be6b-4bd94a891758 imgt:scFv-Kappa-Heavy-Toxin|rdf:type|imgt:ChainType imgt:StudyProduct_b1980817-a889-3103-89c7-3c92cc18dd35|imgt:application_type|Therapeutic imgt:Globo_H|imgt:isTargetOf|imgt:MAbReceptor_1165 imgt:Fc-Alpha|imgt:isDescribedBy|imgt:FC-ALPHA imgt:Product_92aaaa11-a012-35e5-91ee-9df570fa89a7|imgt:hasStudyProduct|imgt:StudyProduct_577f4c82-90c0-3ae2-aa18-5f93ea2a0d6c imgt:Product_5830c2e2-44a5-3e14-982c-9fb387cb368a|imgt:isProductOf|imgt:mAb_659 imgt:VH|rdf:type|imgt:ConstructLabels imgt:9626|rdfs:label|9626 _:B35db288160095edc92ada69989f2a804|imgt:isDecidedBy|imgt:FDA _:B224cb7f2b58146ce0e3ef5cf987b651a|dc:date|2010-01-08 imgt:Asthma|imgt:isClinicalIndicationOf|imgt:StudyProduct_ad0a9104-8ebf-3868-b865-84a871fccf8a imgt:Construct_738|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:StudyProduct_4d43e64a-9282-3b26-a0c8-01df3b1cc94e|imgt:hasClinicalPhase|imgt:Phase_II imgt:mAb_774|imgt:inn_number|10647 imgt:StudyProduct_f5830fbe-63ca-3d3f-999b-81b658186793|imgt:isStudyProductOf|imgt:Product_b16c8a70-63cb-386b-877e-1df7640dae70 _:Bff8a9c5a8d2b44cd87112738140acfb2|imgt:hasDesignation|imgt:Orphan_drug imgt:VPREB1-IGLL1|skos:definition|Chain or receptor comprising one VPREB1 and one IGLL1 domains obo:NCIT_C84237|rdfs:subClassOf|obo:NCIT_C1909 imgt:IgG1-nd_18|rdf:type|imgt:MAbReceptor imgt:Construct_972|imgt:hasImgtLabel|imgt:IgG2-kappa imgt:StudyProduct_bd12a20a-2e90-30be-bc2a-c351c70d24cb|imgt:application_type|Therapeutic imgt:Product_165975b7-c4e2-3663-8b7e-03bb4d0ac418|rdfs:label|Product_165975b7-c4e2-3663-8b7e-03bb4d0ac418 imgt:TGFB3|imgt:isTargetOf|imgt:IgG1-kappa-%5BPROTEIN%5D2_1225 imgt:Centocor_Inc|imgt:produces|imgt:Product_bc3ee6a8-9301-3273-b619-bbd1722230e7 imgt:mAb_1199|imgt:hasMabReceptor|imgt:IgG1-lambda_1199 imgt:Product_50c591cd-103a-3ec1-b4c9-d3d55b7a0ca4|imgt:commun_name|IGN-002 imgt:mAb_1175|imgt:inn_name|pivekimab imgt:Clone_32|rdf:type|obo:NCIT_C37925 imgt:LRR10|skos:definition|Leucine-rich repeat imgt:FPIA_%5BPROTEIN%5D2-FC_475|imgt:isMabReceptorOf|imgt:mAb_475 imgt:Segment_673_1|rdf:type|imgt:Segment imgt:Segment_1174_1|obo:BFO_0000050|imgt:Construct_1174 imgt:mAb_1184|imgt:hasImgtStructureEntry|imgt:11741 imgt:Product_c4ad3947-577f-31a6-9ca5-62124b9ab8cf|imgt:commun_name|RDB-1419 imgt:Product_49d0e51d-fc17-3c61-be0a-87eb08d806f8|imgt:commun_name|REGN 2222 imgt:Melanoma_with_nodal_involvement_after_surgical_resection|imgt:isClinicalIndicationOf|imgt:StudyProduct_6a8a9e2e-2b56-336b-b146-1e73cbaccb25 imgt:10856|imgt:isImgtStructureEntryOf|imgt:mAb_633 imgt:Construct_615|rdf:type|imgt:Construct imgt:Product_950458ce-5b79-3a87-87fd-0d76107f13a3|imgt:hasStudyProduct|imgt:StudyProduct_1476d57e-e613-3ba6-87ff-d89e430f5269 imgt:Product_95ae77ea-c3af-3937-b5e7-521d636349bd|imgt:commun_name|humanized B1-8 imgt:StudyProduct_88996b34-3790-34cd-bbb8-5f84f950c217|imgt:development_technology| VelocImmune® imgt:Product_2d751c55-5d4a-3190-8c83-f07f3ce81971|imgt:isProductOf|imgt:mAb_466 imgt:StudyProduct_c577e61c-dd0a-3058-bf6a-7a818cd5084b|imgt:isStudyProductOf|imgt:Product_39647f9c-5a2a-3d4d-b584-bce5721f1fed imgt:Pain_chronic|imgt:isClinicalIndicationOf|imgt:StudyProduct_6ffb2b85-8092-311b-a673-e688b57d2bf6 imgt:Clone_959|imgt:clone_name|P01-18-P10-18 imgt:IgG1-kappa_1122|imgt:isMabReceptorOf|imgt:mAb_1122 imgt:mAb_642|imgt:inn_number|10213 _:Bb244488168d6454b452f7ddf2859dec5|imgt:hasStatut|imgt:approval imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_66d9d619-83b7-37ca-9a22-944a30f6654b imgt:mAb_938|imgt:hasOriginClone|imgt:Clone_938 imgt:IgG1-kappa_1151|imgt:hasConstruct|imgt:Construct_1151 imgt:Ablynx|rdfs:comment|Ghent/Zwijnaarde , Belgium imgt:mAb_1280|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=1280 imgt:mAb_4|imgt:hasProduct|imgt:Product_6a1f5927-c36a-33fe-aaad-a8f6cfeca910 imgt:StudyProduct_b10109da-0907-32f7-b022-043c15317a58|imgt:hasClinicalIndication|imgt:Graft-versus-host_disease_(GvHD) pubmed:8095956|dc:contributor|Alves K imgt:IgG1-kappa_161|rdfs:label|IgG1-kappa_161 imgt:StudyProduct_e9fde481-76d5-3f46-ac81-d553a0f4bfdc|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:FAB-GAMMA-4_KAPPA|skos:definition|Fab comprising the VH-CH1 domains from a H-GAMMA-4 chain and a L-KAPPA chain imgt:IgG1-kappa_301|imgt:hasConstruct|imgt:Construct_301 imgt:mAb_71|rdf:type|imgt:INN imgt:mAb_1031|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=1031 imgt:StudyProduct_8483c2ef-bfdc-3068-9769-356981862caa|rdfs:label|StudyProduct_8483c2ef-bfdc-3068-9769-356981862caa imgt:Product_8924fb04-237b-37c3-b29a-712a10fcde39|imgt:commun_name|MetMAb imgt:mAb_137|rdf:type|obo:NCIT_C1909 imgt:mAb_429|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=429 imgt:Segment_29_1|rdfs:label|Segment_29_1 _:Bd2325cfbc5b7b2b694efb2f8e2534d03|rdf:type|obo:NCIT_C53285 imgt:Product_b7a7e4bb-f8f0-300e-9c56-2377c788b72a|imgt:isProducedBy|imgt:Center_of_Molecular_Immunology_(CMI) imgt:Cancers_colorectal_(CRC)|imgt:isClinicalIndicationOf|imgt:StudyProduct_79e61b16-943d-371f-988a-4e436816c1c3 imgt:Construct_776|imgt:isConstructOf|imgt:IgG4-kappa-%5BscFv%5D2_776 imgt:mAb_165|imgt:hasBiosimilar|imgt:hefiya imgt:FUSION-TNFRSF1B-GAMMA-1|rdfs:label|FUSION-TNFRSF1B-GAMMA-1 imgt:mAb_870|imgt:hasProduct|imgt:Product_35151183-9d05-3e40-99a6-c6765fb8df78 _:B5e595980c6d9d0f6eae4c3a574e25f56|imgt:hasStatut|imgt:Market_suspension imgt:StudyProduct_0c23c19c-5024-3083-90b4-416d2c92751d|imgt:hasClinicalPhase|imgt:Phase_M imgt:Product_43b270ab-cd45-3fb5-8ca6-df0952c4ef21|imgt:isProductOf|imgt:mAb_1116 imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_4784e7fe-8ef2-3b5d-82a9-2a04b89fe5ff imgt:V-kappa-VH-V-lambda-VH%27_tandAb_1152|http://semanticscience.org/resource/SIO_000291|imgt:bispecific imgt:Segment_624_1|imgt:segment_detail|*a (K56,H57)  24-188 imgt:VEGFA|imgt:isTargetOf|imgt:IgG2-kappa_597 imgt:C-BETA|rdfs:label|C-BETA imgt:IgG1-kappa_941|obo:RO_0002162|imgt:Hum imgt:mAb_986|imgt:inn_proposed_list|121 (2019) imgt:mAb_1004|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=1004 imgt:Fv-Heavy_Kappa|imgt:isDefinedBy|imgt:IG-Light-Kappa-IGKC imgt:Segment_890_1|rdfs:label|Segment_890_1 imgt:mAb_1127|imgt:inn_number|11617 imgt:mAb_739|imgt:hasOriginClone|imgt:Clone_739 _:B39db33206a82aa968e5fec10cac57696|imgt:isDecidedBy|imgt:FDA imgt:Construct_395|rdf:type|imgt:Construct imgt:mAb_1070|rdfs:label|mAb_1070 imgt:Product_73c81dcd-fbbc-38ac-a403-d4b47378e287|imgt:commun_name|MEDI9447 imgt:StudyProduct_78170e97-70c1-3171-ae0d-f8c67e83e3be|rdf:type|obo:NCIT_C174271 imgt:FPIA_%5BPROTEIN-PROTEIN-PROTEIN%5D2-FC_377|imgt:fused_with| Homo sapiens IGHG1 Fc (Fragment constant) imgt:Segment_544_1|rdfs:label|Segment_544_1 imgt:IgG1-nd_49|http://semanticscience.org/resource/SIO_000291|imgt:MUC1 imgt:Genzyme_Corp|imgt:produces|imgt:Product_84e76124-e7a6-3d53-bb0d-67db69ff6aa5 imgt:Product_c5655770-b6fa-3ca9-a0be-de4d35304022|rdfs:label|Product_c5655770-b6fa-3ca9-a0be-de4d35304022 imgt:riabni™|imgt:isBiosimilarOf|imgt:mAb_161 imgt:IgG1-nd_840|imgt:hasMolecularComponent|imgt:IG obo:NCIT_C166609|rdfs:subClassOf|obo:NCIT_C1909 imgt:Product_3647ef58-7624-3de0-9563-f865a03f40de|imgt:hasStudyProduct|imgt:StudyProduct_4eb26815-b8de-3cc1-99ea-3b5008556527 _:B56a14cf71b8806e2a74d2fb7af6cd68e|dc:date|2004-11-23 imgt:StudyProduct_e31dd7aa-eea2-3b74-927d-33dcab3587b6|imgt:application_type|Therapeutic imgt:IL12B_(Pr1-24)|skos:definition|Interleukin-12 subunit beta imgt:Segment_407_1|imgt:has_rank|1 imgt:Product_0dea9063-7da8-3df3-9249-b5cddeecec56|imgt:commun_name|PankoMab imgt:ImmunoGen_Inc|imgt:produces|imgt:Product_6046a785-1f37-30d3-8151-7ba14caa56ee imgt:StudyProduct_469cff43-353e-3dd0-8e72-af6505cb07c0|imgt:isStudyProductOf|imgt:Product_8ce04d69-ff3a-3c28-a88f-ba8875ab2e2a imgt:Scleroderma|imgt:isClinicalIndicationOf|imgt:StudyProduct_3f946c8d-a436-351a-8ff1-340d491a42a7 imgt:Clone_603|imgt:isOriginCloneOf|imgt:mAb_603 imgt:FPIA_%5BPROTEIN_3DOMAINS_3CLIKE-PROTEIN_3DOMAINS_3CLIKE%5D2-FC_217|rdf:type|imgt:MAbReceptor imgt:mAb_378|imgt:inn_name|crenezumab imgt:IgM_Iota-1|rdf:type|imgt:ReceptorType imgt:StudyProduct_7cf9c789-4569-32e3-b570-6f6bd2343490|imgt:isStudyProductOf|imgt:Product_705ed763-9a95-3dbd-9dae-53dd2e5131cc imgt:mAb_746|imgt:hasProduct|imgt:Product_d5350037-131c-3c49-b8c9-135b87e90bc3 imgt:IgG1-kappa_720|rdf:type|imgt:MAbReceptor imgt:11366|imgt:isImgtStructureEntryOf|imgt:mAb_1066 imgt:Product_5994f2d0-2c12-3fdb-820c-747cc0c851a0|imgt:isProducedBy|imgt:Cambridge_Antibody_Technology imgt:Janssen_Biotech_Inc|imgt:produces|imgt:Product_4fca6fa6-19ec-3b75-967c-377d6768e2ef imgt:StudyProduct_b9490482-f599-3976-bddb-2fd9f2677311|rdf:type|obo:NCIT_C174271 _:Bdd8155ad4972ea822af395505cac7bf3|rdf:type|obo:NCIT_C53285 imgt:11838|imgt:isImgtStructureEntryOf|imgt:mAb_1202 imgt:StudyProduct_0dce2b38-b5c1-3b34-9beb-fc4154b2b406|imgt:isStudyProductOf|imgt:Product_92aaaa11-a012-35e5-91ee-9df570fa89a7 imgt:StudyProduct_e5918f1b-dab3-337e-9cbd-91ad992f0a2a|imgt:application_type|Therapeutic imgt:Amgen|imgt:produces|imgt:Product_39647f9c-5a2a-3d4d-b584-bce5721f1fed imgt:Construct_501|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Product_5a668ad8-7ea1-3577-99d8-247bff544b04|rdfs:label|Product_5a668ad8-7ea1-3577-99d8-247bff544b04 imgt:mAb_377|imgt:inn_number|9487 imgt:Product_21e3de09-e3c8-331b-a1c1-8afb6a369105|rdfs:label|Product_21e3de09-e3c8-331b-a1c1-8afb6a369105 imgt:Product_b38076b1-97d5-32d7-963f-54f73830057b|imgt:hasStudyProduct|imgt:StudyProduct_f0431bbe-f9ca-3eba-a26f-88d04c64aaaf imgt:Segment_1045_2|imgt:has_rank|2 imgt:Construct_447|obo:BFO_0000051|imgt:Segment_447_1 imgt:12001|imgt:isImgtStructureEntryOf|imgt:mAb_1217 imgt:Product_9215dd29-19a5-360f-9f0c-c9c5d5534fe4|imgt:isProductOf|imgt:mAb_1086 imgt:Chengdu_Kanghong_Biotech_CoLtd|rdf:type|obo:NCIT_C54131 imgt:Construct_1012|obo:BFO_0000051|imgt:Segment_1012_1 imgt:Product_83a8b77d-1ab1-3039-b735-4876ec3ef72f|imgt:comercial_name|BLINCYTO® imgt:mAb_175|imgt:hasMabReceptor|imgt:IgG1-kappa_175 imgt:IgG3-kappa_199|http://semanticscience.org/resource/SIO_000291|imgt:carcinoma_associated_antigen_CTAA16 imgt:Product_d6b7487b-6d4c-3cd4-8d1a-5ffd835eec19|imgt:hasStudyProduct|imgt:StudyProduct_aedffa5f-0866-31f3-b361-3e84aef3d109 imgt:Transcenta_Holding_Ltd|rdf:type|obo:NCIT_C54131 imgt:Adenocarcinoma_gastric|rdfs:label|Adenocarcinoma_gastric imgt:LINGO1|rdfs:label|LINGO1 imgt:TGFB1|imgt:isTargetOf|imgt:IgG1-kappa-%5BPROTEIN%5D2_1225 imgt:IgG1-kappa-4cys-drug_532|rdfs:label|IgG1-kappa-4cys-drug_532 imgt:Product_3f5245a0-72f1-3dc9-a7a9-7568f71c5db6|imgt:isProductOf|imgt:mAb_1243 imgt:Construct_567|imgt:isConstructOf|imgt:IgG1-kappa_567 imgt:Construct_1064|obo:BFO_0000051|imgt:Segment_1064_1 imgt:StudyProduct_f00d500d-e77e-390f-81f4-b51fbab69ce3|rdf:type|obo:NCIT_C174271 imgt:Product_7ee1000f-7a38-3b1d-9440-c9f59adf1731|imgt:commun_name|CH14.18/CHO imgt:StudyProduct_5bd02808-d4e2-368d-9b8b-7016ac2fe3e5|rdfs:label|StudyProduct_5bd02808-d4e2-368d-9b8b-7016ac2fe3e5 imgt:Product_92c8c96e-4c37-3007-b7c7-190b76d28233|imgt:commun_name|rhuMAb imgt:StudyProduct_a78a0ef6-c705-3475-860d-516b5d771dea|imgt:isStudyProductOf|imgt:Product_25709140-bbc7-373c-9a44-2be9be3d8e9d imgt:StudyProduct_edecf533-0f48-3169-b1b6-54b81c7e8009|imgt:hasDecision|_:B006945158199dca532098d6d4eaf1361 imgt:StudyProduct_0eff14ed-1068-3f6d-bf44-6823ff8f985a|imgt:application_type|Therapeutic _:B6a79c6f0bc2fb1962abdfec6240a1584|dc:date|2020-01-21 imgt:StudyProduct_4cdd49cd-0f02-370e-95fe-8121a698d4fe|rdf:type|obo:NCIT_C174271 imgt:mAb_858|rdfs:label|mAb_858 imgt:J-REGION|rdf:type|imgt:CoreLabel imgt:StudyProduct_d38edf7d-aeb0-3e27-a95e-d4464805635c|imgt:hasClinicalPhase|imgt:Phase_II _:Be94718665d2921ee93156f126f0b8684|imgt:isDecisionOf|imgt:StudyProduct_6f1c296e-aefa-346a-ae77-b60731c49c21 imgt:StudyProduct_ddfca829-8b00-399e-baed-0a1b0ac4cf92|rdfs:label|StudyProduct_ddfca829-8b00-399e-baed-0a1b0ac4cf92 imgt:commun_name|rdf:type|owl:AnnotationProperty imgt:Construct_796|obo:BFO_0000051|imgt:Segment_796_1 obo:NCIT_C167039|rdf:type|owl:Class imgt:Product_f5eb8070-c0e6-3c90-8a3e-0480be89ee9b|imgt:hasStudyProduct|imgt:StudyProduct_340cb88e-bb79-3b53-9e2a-cbd43b517c55 imgt:Segment_1109_1|imgt:has_rank|1 https://doi.org/10.1371/journal.pmed.0030237|dc:contributor|Bogaards J.A. imgt:StudyProduct_97df522c-ff88-36a0-be77-ae83c150f1af|imgt:application_type|Therapeutic imgt:mAb_1149|rdf:type|imgt:INN imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_ac7cbd2f-438d-317d-9a14-b42057ef30b1 imgt:StudyProduct_a7811b4e-4519-3e4d-87c6-9e1f3528a52a|imgt:application_type|Therapeutic _:B1129e1d3102232ec22c0125b6eaa45f1|rdf:type|obo:NCIT_C53285 _:Bccccba18e8edb675d685cc77675567ea|rdf:type|obo:NCIT_C53285 imgt:3'END-REGION|rdfs:label|3'END-REGION imgt:Product_c4526586-07f1-3afc-81e7-ecabc79a2f1c|rdfs:label|Product_c4526586-07f1-3afc-81e7-ecabc79a2f1c imgt:StudyProduct_d08001fe-9bd8-377d-b56d-2cffd39b2bdd|imgt:hasClinicalIndication|imgt:Cancers_non-small_cell_lung_(NSCLC) imgt:IgG1-kappa_1204|imgt:isMabReceptorOf|imgt:mAb_1204 imgt:StudyProduct_f8872358-c5ae-3d19-aa7e-89ec0f830df2|imgt:application_type|Therapeutic imgt:ABL1|rdf:type|imgt:RPILabel imgt:StudyProduct_4b851f49-d7ec-3723-ad3b-48dd091181b6|imgt:application_type|Therapeutic _:Bfc0949419dd587e2ccb388ac01fc935e|dc:date|2019-04-23 _:B16b2485caf9cc8c1b0d6fb1cb27f3f56|imgt:hasStatut|imgt:approval imgt:Construct_387|rdfs:label|Construct_387 _:Bd5f676da51f0c5c1ddf41d4aa14899cd|imgt:hasStatut|imgt:approval imgt:scFv-heavy-kappa-scFv-kappa-heavy-CD8A(CO-TM)-TNFRSF9(CY)-CD247_1161|rdfs:label|scFv-heavy-kappa-scFv-kappa-heavy-CD8A(CO-TM)-TNFRSF9(CY)-CD247_1161 imgt:IgG4-kappa_649|rdf:type|imgt:MAbReceptor imgt:Asthma|imgt:isClinicalIndicationOf|imgt:StudyProduct_5dfab0f8-3162-3056-88ee-a9b350e65d01 imgt:Product_50c4b5c5-024d-321f-b6c3-e7ff39741c4e|imgt:hasStudyProduct|imgt:StudyProduct_76ed5004-fdcf-3c32-b93d-ddd111280196 imgt:IgG1-kappa-6cys-drug_558|imgt:via_a| maleimide-type cleavable linker (carbonate group, 4-aminobenzyl alcohol and cathepsine-B-cleavable dipeptide Phe-Lys) and containing a triazoline group and a spacer PEG (n=8) imgt:StudyProduct_a720fa50-312f-3e4f-8874-d39007ec9f23|rdf:type|obo:NCIT_C174271 imgt:Melanoma_associated_proteoglycans_(PG)|skos:definition|Melanoma associated proteoglycans (PG) imgt:6XDG|rdf:type|obo:NCIT_C25402 imgt:Clone_295|rdf:type|obo:NCIT_C37925 obo:NCIT_C132252|rdf:type|owl:Class imgt:StudyProduct_07e24932-2d26-39e7-a81c-1aecbcf488ab|rdf:type|obo:NCIT_C174271 imgt:Product_2624320e-1e97-3af4-89b8-c8b313ff97f4|imgt:comercial_name|EPOGEN® imgt:mAb_1079|imgt:inn_number|11451 imgt:StudyProduct_163d3209-b354-3651-af01-31d9aea18d8b|imgt:isStudyProductOf|imgt:Product_6749bce5-ca17-3a1e-b6a6-716da8fc041b imgt:mAb_357|imgt:atc_link|http://www.whocc.no/atc_ddd_index/?code=L01XC14 imgt:StudyProduct_752e70d2-579b-3561-9749-03044f0090ff|imgt:application_type|Therapeutic imgt:Product_c15ba6a8-8daa-3074-95f7-355d243fc743|imgt:commun_name|14.18 imgt:StudyProduct_1e889c67-be7c-3760-ab07-076c42d2f8ce|imgt:development_technology| Abgenix's XenoMouse® imgt:CONJUGATE-%5BOXYNTOMODULIN-ANALOG-PEGLINK%5D1-FC-GAMMA-4|skos:definition|conjugate protein for immune application (FPIA) comprising Oxyntomodulin analog - PEG fused with immunoglobulin G4 FC fragment imgt:Segment_1199_1|obo:BFO_0000050|imgt:Construct_1199 imgt:StudyProduct_34d69582-3597-3e4c-97ff-4e497863da54|imgt:hasClinicalIndication|imgt:Cutaneous_melanoma_lesions imgt:StudyProduct_a2e8785b-8e64-32ac-a118-35191a7832a5|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:ENZ_1DOMAIN_1047|rdfs:comment|ENZ_1DOMAIN imgt:StudyProduct_567dca9c-f362-30db-b121-50386b4dbb4b|imgt:hasClinicalIndication|imgt:Inflammatory_conditions imgt:StudyProduct_c5762f39-ceaa-3bef-b2bc-1b12f751b0d8|imgt:application_type|Therapeutic imgt:Clone_87|rdfs:label|Clone_87 _:B3ec5340dfe66cfdc4aec1d3b5cbb4c02|imgt:isDecidedBy|imgt:FDA imgt:mAb_876|imgt:hasImgtStructureEntry|imgt:10522 imgt:10082|rdfs:label|10082 imgt:TR-GAMMA-3|rdf:type|imgt:ChainLabels obo:NCIT_C170107|rdf:type|owl:Class imgt:IgG1-kappa_291|rdf:type|imgt:MAbReceptor imgt:StudyProduct_75d253d7-82de-38d0-bb06-ec931e28c1e1|rdfs:label|StudyProduct_75d253d7-82de-38d0-bb06-ec931e28c1e1 imgt:Segment_1051_1|rdfs:label|Segment_1051_1 imgt:IG-GAMMA-1-%5BIL2%5D1_KAPPA|rdf:type|imgt:IGEngineeredLabel imgt:StudyProduct_1289578f-2bc9-3bf7-9a21-741d6e16a068|rdfs:label|StudyProduct_1289578f-2bc9-3bf7-9a21-741d6e16a068 imgt:mAb_1106|imgt:imgt_note| WHO Drug Information, Vol. 34, No. 3, 2020. Proposed INN List 124 – COVID-19 (special edition) (9 October 2020) pages 642-669. Proposed INN List 124 (19 December 2020, published on 22 January 2021) pages 929-1102. On August 12, 2021, Food and Drug Administration (FDA) issued an Emergency Use Authorization (EUA) for emergency use of tixagevimab with cilgavimab as pre-exposure prophylaxis for prevention of coronavirus disease 2019 (COVID-19) in adults and pediatric individuals. Press release Letter of authorization imgt:IgD_Lambda|rdf:type|imgt:ReceptorType imgt:Product_54de5f46-b57e-3e11-b0b1-5114ea870b86|imgt:isProductOf|imgt:mAb_58 imgt:L-LAMBDA-5|rdfs:label|L-LAMBDA-5 imgt:mAb_1097|imgt:hasMabReceptor|imgt:IgG2a-lambda_1097 obo:SO_0000530|rdf:type|owl:Class imgt:10501|imgt:isImgtStructureEntryOf|imgt:mAb_791 imgt:Psoriatic_arthritis_(PSA)|imgt:isClinicalIndicationOf|imgt:StudyProduct_71208dab-9f1e-3a59-b5e7-e15f341ef594 imgt:Construct_226|rdfs:label|Construct_226 imgt:Construct_496|obo:BFO_0000051|imgt:Segment_496_1 imgt:mAb_53|rdf:type|imgt:INN imgt:mAb_584|imgt:inn_name|bevacizumab beta imgt:mAb_124|imgt:hasProduct|imgt:Product_74d376fb-ff8e-340f-a10b-23eefb61dbad imgt:mAb_1149|imgt:inn_recommended_list|86 (2021) imgt:J-transcript|imgt:hasMoleculeType|imgt:mRNA _:Bd3110e9f41efc15d28ebdbac7ba3b8fb|imgt:isDecisionOf|imgt:StudyProduct_a4a7bca6-26d4-3a2d-b63d-927b4e781968 imgt:StudyProduct_0dcdba1a-4892-3b76-9329-063e77b05f44|imgt:hasClinicalIndication|imgt:Increased_levels_of_IL6_in_sepsis obo:NCIT_C118578|rdfs:subClassOf|obo:NCIT_C1909 imgt:mAb_618|imgt:inn_number|10296 imgt:Segment_387_1|obo:BFO_0000050|imgt:Construct_387 imgt:StudyProduct_e8de6321-19d6-3051-8bd9-c4b71bd85892|rdf:type|obo:NCIT_C174271 imgt:Product_8281a068-f894-3608-8a65-2649dfe666a9|rdf:type|obo:NCIT_C51980 imgt:Construct_973|imgt:isConstructOf|imgt:IgG4-kappa-lambda_973 imgt:Product_4391f6b4-98b1-38e2-94d2-967326f820fe|imgt:hasStudyProduct|imgt:StudyProduct_498cf157-d9e4-3845-ab8e-e84d45abd28d imgt:mAb_402|imgt:inn_proposed_list|106 (2011) imgt:1BJ1|imgt:isImgtStructureEntryOf|imgt:mAb_24 imgt:Product_b1370aed-0f04-32a5-9fa3-29cf7e6cb0c7|imgt:isProducedBy|imgt:Berlex_Inc imgt:IFNG_(Pr21-161)|skos:definition|Interferon gamma imgt:mAb_950|rdfs:label|mAb_950 imgt:Product_c5ef56a8-976b-3908-a950-7c23335315c5|rdfs:label|Product_c5ef56a8-976b-3908-a950-7c23335315c5 imgt:mAb_587|imgt:inn_number|10121 _:Bf6c1c04a66a751fecfebacc0af9a77f4|imgt:isDecidedBy|imgt:FDA imgt:IgG1-kappa_400|http://semanticscience.org/resource/SIO_000291|imgt:IL6R imgt:Construct_869|obo:BFO_0000051|imgt:Segment_869_1 imgt:Product_03bd8656-46d5-3883-867e-29737a9f2afe|rdfs:label|Product_03bd8656-46d5-3883-867e-29737a9f2afe imgt:L-LAMBDA|rdfs:label|L-LAMBDA imgt:isBiosimilarOf|rdfs:range|obo:NCIT_C1909 imgt:Product_3c59ddc7-2c9e-3f59-aa28-0ec6b12703f4|imgt:isProductOf|imgt:mAb_185 imgt:StudyProduct_9b52f642-d4b7-3cc8-93f2-281f15bb283c|rdf:type|obo:NCIT_C174271 imgt:Clone_368|imgt:clone_name|5D5 imgt:StudyProduct_3a8557c2-af91-375e-9476-72214852a437|imgt:hasClinicalIndication|imgt:Cancers_prostate imgt:mAb_403|imgt:inn_name|flanvotumab obo:NCIT_C173804|rdfs:subClassOf|obo:NCIT_C1909 obo:NCIT_C174871|rdfs:subClassOf|obo:NCIT_C1909 imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_3641cbab-419b-324f-882f-719f12d8073d imgt:mAb_1055|rdfs:label|mAb_1055 imgt:Product_07665b8f-c82c-38d0-a61a-3c526b0a1864|rdfs:label|Product_07665b8f-c82c-38d0-a61a-3c526b0a1864 imgt:Construct_82|obo:BFO_0000051|imgt:Segment_82_3 imgt:IgG1-kappa_853|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:10923|rdf:type|obo:NCIT_C25402 imgt:StudyProduct_419a4556-e132-397a-82cb-9be68da5963f|imgt:application_type|Therapeutic imgt:Construct_255|obo:BFO_0000051|imgt:Segment_255_1 imgt:Construct_863|imgt:isConstructOf|imgt:IgG4-kappa_863 imgt:StudyProduct_183723a2-9e1e-37d0-a6a5-baba572d43c4|imgt:isStudyProductOf|imgt:Product_ed8a74ee-19be-3e61-b1da-90ff79b0637d _:B865a69dfe442b873dbe55e79f1446904|imgt:isDecisionOf|imgt:StudyProduct_e1b0df76-22f6-3038-be8d-9366276b38e7 imgt:Construct_65|obo:BFO_0000051|imgt:Segment_65_1 imgt:StudyProduct_e3b31fb7-d1c1-364c-a5a4-bf9da72bae9d|imgt:isStudyProductOf|imgt:Product_48cbaf81-49be-39c7-9cc5-047872a6fdbe imgt:mAb_265|imgt:hasMabReceptor|imgt:IgG1-kappa_265 _:Bfb6b5f5f1e7561d7255233388ba98f3b|rdf:type|obo:NCIT_C53285 imgt:Clone_602|obo:RO_0002162|imgt:Musmus imgt:mAb_149|imgt:inn_number|8734 imgt:Product_c67d4f68-56c4-3c24-8eaa-730b7fd45aaf|rdf:type|obo:NCIT_C51980 imgt:RepeatLabel|rdf:type|owl:Class imgt:mAb_240|imgt:inn_recommended_list|61 (2009) imgt:Product_c8f3b081-bdf9-3d9e-b6ca-5c7797adc6ad|imgt:hasStudyProduct|imgt:StudyProduct_07dd16c8-3f11-3079-a7fb-eb7223ccb46a imgt:AbbVie_Inc|imgt:produces|imgt:Product_5c04be23-e79a-3cda-a452-c8c13a5d1811 imgt:Product_d9212299-036c-39af-b29c-31d7fe01268c|rdf:type|obo:NCIT_C51980 imgt:StudyProduct_f95e7e1c-4453-3bfe-835c-1245dfb30b90|imgt:hasClinicalIndication|imgt:Cancers imgt:Segment_162_1|imgt:has_rank|1 imgt:IGHE|imgt:isTargetOf|imgt:IgG1-nd_68 imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_9e3781cc-21f2-3583-b63d-a970342c3ed1 imgt:FPIA_%5BPROTEIN_4REPEATS%5D2-FC_288|rdf:type|imgt:MAbReceptor imgt:StudyProduct_3ce51bf4-2da7-3b9c-8a07-55b43d4693c3|rdf:type|obo:NCIT_C174271 imgt:Product_9b8fd23d-77df-3897-9633-83ec58c245d0|imgt:hasStudyProduct|imgt:StudyProduct_f8a4c682-c797-36a3-8307-cf75265eec3a imgt:Segment_643_1|obo:BFO_0000050|imgt:Construct_643 imgt:Product_c3e77c6d-5c6a-3f85-a3a3-d27127306a24|rdfs:label|Product_c3e77c6d-5c6a-3f85-a3a3-d27127306a24 imgt:IgG1-kappa_48|imgt:hasMolecularComponent|imgt:IG imgt:StudyProduct_2afc056f-f82d-38cf-8be5-284f8ce96916|rdf:type|obo:NCIT_C174271 imgt:Construct_177|imgt:isConstructOf|imgt:IgG1-kappa_177 imgt:Segment_377_3|rdfs:label|Segment_377_3 imgt:mAb_636|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=636 imgt:Product_bb7aebc4-a07c-3a88-9fc9-cf9cf1d066cd|imgt:isProducedBy|imgt:XBiotech imgt:PTCRA|rdf:type|imgt:ChainLabels imgt:StudyProduct_35e40934-ef71-3abc-a80e-c90f9275260f|imgt:hasClinicalIndication|imgt:Ankylosing_spondylitis_(AS) imgt:CHX|skos:definition|unusual exon CHX of IG heavy C-GENE in gDNA, or CHX region in cDNA imgt:mAb_97|imgt:inn_proposed_list|78 (1997) imgt:F8|rdf:type|imgt:ChainLabels imgt:Diartis_Pharmaceutical|rdf:type|obo:NCIT_C54131 imgt:Product_4fca6fa6-19ec-3b75-967c-377d6768e2ef|rdfs:label|Product_4fca6fa6-19ec-3b75-967c-377d6768e2ef imgt:ANX1_(Pr7-87)|rdfs:label|ANX1 (Pr7-87) imgt:mAb_597|imgt:imgt_note| navicixizumab, a bispecific antibody, binds the cell surface target DLL4 with one binding site and the soluble ligand VEGFA with the other one. imgt:StudyProduct_1bffc5d9-6be7-3f6f-aec0-82c150cfc547|imgt:hasClinicalPhase|imgt:Phase_III imgt:Product_c49fe1bd-70e4-3192-91d0-1125b060119b|imgt:isProductOf|imgt:mAb_71 imgt:mAb_148|rdf:type|imgt:INN imgt:StudyProduct_49c97a1d-0850-3fad-97df-ddda4fd3e497|imgt:hasClinicalPhase|imgt:Phase_I/II imgt:StudyProduct_55222386-95f1-3c39-b73c-b6e578c31ef5|rdfs:label|StudyProduct_55222386-95f1-3c39-b73c-b6e578c31ef5 imgt:mAb_1110|rdf:type|imgt:INN imgt:Segment_979_1|rdf:type|imgt:Segment imgt:Cancers_pancreatic|imgt:isClinicalIndicationOf|imgt:StudyProduct_6a7ed135-7a87-3e0e-820b-d9242f841d83 imgt:StudyProduct_9b348c98-7f02-303c-a16d-d7c0e68400ab|rdfs:label|StudyProduct_9b348c98-7f02-303c-a16d-d7c0e68400ab imgt:IgG2-kappa_495|imgt:hasConstruct|imgt:Construct_495 imgt:mAb_286|rdf:type|obo:NCIT_C1909 imgt:Construct_1021|imgt:isConstructOf|imgt:IgG4-kappa_1021 pubmed:20035694|rdfs:label|PMID_20035694 imgt:StudyProduct_0ce16fcd-0422-3691-b428-09a6529269c9|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:CD2|imgt:isTargetOf|imgt:IgG1-kappa_71 imgt:StudyProduct_3368c03f-aa59-37c6-982b-b1971a1c3a45|imgt:hasClinicalIndication|imgt:Asthma imgt:Construct_455|obo:BFO_0000051|imgt:Segment_455_1 imgt:Clone_1006|imgt:clone_name|TP15-4 imgt:StudyProduct_58fd01ed-11b1-3d24-b0db-8844bb814951|imgt:application_type|Therapeutic imgt:Segment_849_1|imgt:has_rank|1 imgt:Segment_872_3|rdf:type|imgt:Segment imgt:Product_4391f6b4-98b1-38e2-94d2-967326f820fe|imgt:comercial_name|KEYTRUDA® imgt:StudyProduct_82ef3673-2a2e-3294-a68e-00e86e1b0da1|imgt:isStudyProductOf|imgt:Product_4a76dcbb-71d0-3976-a73c-e3c49cbaf19f imgt:mAb_536|imgt:inn_recommended_list|74 (2015) imgt:StudyProduct_1049da7f-b34b-3f12-9d37-0b7d81e03fdd|rdf:type|obo:NCIT_C174271 _:B6002ada4682b303176b493283b784aae|imgt:isDecidedBy|imgt:FDA imgt:Product_9ca3f219-2e71-3bf0-b0d2-618aa2f34e31|imgt:commun_name|HuM195 imgt:StudyProduct_51968d7f-912f-3f32-8f66-70b937860f4d|imgt:hasClinicalPhase|imgt:Phase_I imgt:Segment_1045_1|rdf:type|imgt:Segment imgt:StudyProduct_a092c113-ef53-3347-91ad-e98ef6b5ee07|rdf:type|obo:NCIT_C174271 imgt:Product_e8622868-8b57-3e77-b971-d5d37d61b031|imgt:isProductOf|imgt:mAb_400 imgt:9838|rdf:type|obo:NCIT_C25402 imgt:12040|rdfs:label|12040 imgt:F(ab%27)2-G1-kappa-PROT_1226|rdfs:comment|F(ab')2-G1-kappa-PROT imgt:Ankylosing_spondylitis_(AS)|imgt:isClinicalIndicationOf|imgt:StudyProduct_cd2510d3-90f0-37ba-a6f9-504913366008 imgt:_YB2/0_rat_hybridoma_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_042b03a0-41dd-309b-b2e2-8e0df46eb148 imgt:Pulmonary_arterial_hypertension_(PAH)|imgt:isClinicalIndicationOf|imgt:StudyProduct_2a63f436-c3f9-30bd-a295-2e53a5ab32b6 imgt:StudyProduct_1f9c25e9-dd47-3d6f-995e-3d7688808037|imgt:hasClinicalIndication|imgt:Solid_tumors imgt:9747|imgt:isImgtStructureEntryOf|imgt:mAb_747 obo:NCIT_C156061|rdfs:subClassOf|obo:NCIT_C1909 imgt:Solid_tumors_advanced_or_metastatic|imgt:isClinicalIndicationOf|imgt:StudyProduct_2d768be6-3423-3d2e-af4f-a92794541449 imgt:Segment_1279_1|obo:BFO_0000050|imgt:Construct_1279 imgt:StudyProduct_eba550c7-d4c5-3404-9bd1-41a9355ec09c|imgt:isStudyProductOf|imgt:Product_4e4ab0ff-b8e5-3715-8f65-3904933d179e imgt:StudyProduct_a8d4d541-9193-3ea5-a4f1-395c76adefc8|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:Product_6fff76bc-baa0-3e3c-9cf8-839e804eb2ac|rdfs:label|Product_6fff76bc-baa0-3e3c-9cf8-839e804eb2ac imgt:Product_ee7807fb-0636-3cbb-885a-583c3ec19047|imgt:isProductOf|imgt:mAb_312 imgt:mAb_609|rdfs:label|mAb_609 imgt:Ewing_sarcoma|rdfs:label|Ewing_sarcoma imgt:FPIA_%5BPROTEIN%5D2-FC_446|obo:RO_0002162|imgt:Homsap imgt:12040|rdf:type|obo:NCIT_C25402 imgt:1C-LIKE-4F-DOMAIN|skos:definition|Chain or receptor comprising a chain with one C-LIKE and four F-DOMAIN imgt:Solid_tumors|imgt:isClinicalIndicationOf|imgt:StudyProduct_0e404088-fe07-3e25-8630-993e3507585c imgt:Clone_161|rdf:type|obo:NCIT_C37925 imgt:StudyProduct_772021ea-8f08-37d4-a45a-9616e5a489d0|imgt:hasDecision|_:B19669455770995ecfb982801baea60de imgt:StudyProduct_a8e8e872-ce06-325d-bfd3-06fc7a1561b1|rdf:type|obo:NCIT_C174271 imgt:V-(VDJ)-J-CLUSTER|rdfs:label|V-(VDJ)-J-CLUSTER imgt:4X7S|imgt:isImgtStructureEntryOf|imgt:mAb_77 imgt:Clone_490|obo:RO_0002162|imgt:Musmus imgt:unprocessed|rdf:type|imgt:Molecule_StructureType _:B82f7aea8366d680a656dc2abbce52922|imgt:hasDesignation|imgt:Orphan_drug imgt:mAb_149|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=149 imgt:Clone_199|obo:RO_0002162|imgt:Homsap imgt:Product_cdc45b30-bcf4-349d-8058-1bb480d4bfe2|imgt:hasStudyProduct|imgt:StudyProduct_a615d6f8-edad-3175-995f-1095d09a145f imgt:IgG1-nd_437|rdfs:label|IgG1-nd_437 imgt:byooviz™|imgt:isBiosimilarOf|imgt:mAb_84 imgt:Product_12795352-592b-3769-b822-3a051d3b326d|rdf:type|obo:NCIT_C51980 imgt:ZAP70|rdf:type|imgt:RPILabel imgt:Segment_1194_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:mAb_540|rdfs:label|mAb_540 imgt:10467|rdfs:label|10467 imgt:MAPT|imgt:isTargetOf|imgt:IgG4-kappa_977 imgt:mAb_1014|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=1014 imgt:TNFSF18_(Pr1-199)|rdf:type|imgt:DomainLabel imgt:mAb_1298|rdf:type|obo:NCIT_C1909 imgt:mAb_580|imgt:imgt_note| anti-CD3 specificity, against CD3E, to be confirmed imgt:Product_6a1cb947-c2d5-34b2-8eeb-4b8d2758875a|imgt:hasStudyProduct|imgt:StudyProduct_45e73f84-442e-3c10-b0db-af834591fbfc _:Bf3cd6d748f952280256d5275fb9e1925|rdf:type|obo:NCIT_C53285 imgt:Product_5024ee29-d1ef-33f4-9ff5-34e4c3a98933|imgt:isProductOf|imgt:mAb_642 imgt:mAb_280|imgt:hasProduct|imgt:Product_92c8c96e-4c37-3007-b7c7-190b76d28233 imgt:StudyProduct_85b6b72e-1238-3b69-a3e0-ce8bd39a5396|imgt:hasClinicalPhase|imgt:Phase_I imgt:StudyProduct_cd2510d3-90f0-37ba-a6f9-504913366008|imgt:application_type|Therapeutic imgt:Construct_215|imgt:isConstructOf|imgt:FPIA_%5BPROTEIN_VLIKE%5D2-FC_215 imgt:StudyProduct_713f39e5-5436-3c08-a656-0d04e63bb669|imgt:hasClinicalIndication|imgt:Allergy imgt:Construct_1038|imgt:hasImgtLabel|imgt:IgG4-kappa imgt:Construct_553|imgt:isConstructOf|imgt:IgG1-kappa_553 imgt:Segment_397_2|imgt:has_rank|2 imgt:mAb_322|imgt:imgt_note| sifalimumab INN definition is the one amended in L104 (2010) and published in R65 (2011). In 2007, AstraZeneca bought MedImmune created in 1988. On Feb 14, 2019, it was announced that MedImmune will cease to exist as an industry name as the owner AstraZenaca has decided to retire the brand as part of ongoing restructuring efforts.https://www.biopharmadive.com/news/astrazeneca-retires-medimmune-name-amid-sales-turnaround/548489/ pubmed:14676105|dc:contributor|Ikle DN imgt:mAb_631|imgt:inn_name|filgrastim imgt:2HWZ|rdfs:label|2HWZ _:Bac964193X2D3aecX2D40f8X2D8a6aX2D5b9783845567|rdf:rest|_:Bb68bd9d4X2Dade4X2D4020X2Db35eX2D031cd157db72 imgt:mAb_601|rdf:type|obo:NCIT_C166749 imgt:Product_17ddf92e-c382-3c3c-b38b-fe0f24dae88d|imgt:commun_name|Ha15-10ac.1vcMMAE imgt:Construct_940|obo:BFO_0000051|imgt:Segment_940_1 imgt:IgG2-kappa-lambda_2bridges_593|obo:RO_0002162|imgt:Can imgt:mAb_733|imgt:hasImgtStructureEntry|imgt:10477 imgt:StudyProduct_3d01ec3f-9a3b-3605-90a3-166a7e5d50e2|imgt:development_technology| Cambridge Antibody Technology (CAT) human antibody phage display library imgt:IgG1-kappa_329|imgt:hasConstruct|imgt:Construct_329 imgt:IgG1-kappa_240|obo:RO_0002162|imgt:Hum imgt:CD4_(p55_T_cell_surface_antigen_T4/Leu-3)-Pseudomonas_aeruginosa_exotoxin_A|rdfs:label|CD4 (p55, T cell surface antigen T4/Leu-3) - Pseudomonas aeruginosa exotoxin A imgt:Segment_699_1|rdf:type|imgt:Segment imgt:StudyProduct_ba9e9204-abc8-3172-8a91-386bfbb5abb7|imgt:hasClinicalIndication|imgt:Cancers imgt:Construct_846|rdf:type|imgt:Construct imgt:_YB2/0_rat_hybridoma_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_fcde6171-1334-344c-8c41-75e1d52240e1 imgt:Segment_7_1|imgt:has_rank|1 imgt:IgG1-lambda_1199|rdfs:label|IgG1-lambda_1199 imgt:IgM-kappa_193|imgt:isMabReceptorOf|imgt:mAb_193 imgt:Seattle_genetics_Inc|rdfs:label|Seattle genetics, Inc. _:B146ef11d7eb0000eeee448015f51d805|rdf:type|obo:NCIT_C53285 imgt:Product_cfe88c2c-d2ae-3147-9c05-ec936c4308da|rdf:type|obo:NCIT_C51980 imgt:IgG4-kappa_969|http://semanticscience.org/resource/SIO_000291|imgt:PDCD1 imgt:IgG4-kappa_353|rdf:type|imgt:MAbReceptor _:B94dd5d9cbe6add4da11806501e4367c3|rdf:type|obo:NCIT_C53285 imgt:StudyProduct_5fd82fcb-b163-3742-9246-bea610f85fff|imgt:development_technology| MorphoSys's HuCAL® phage library imgt:IgG1-kappa_427|rdfs:label|IgG1-kappa_427 imgt:mAb_1046|rdf:type|obo:NCIT_C175101 imgt:StudyProduct_7f439e60-29e2-39db-a44a-9727a9db98cb|imgt:hasClinicalPhase|imgt:Phase_II imgt:IgG1-kappa-4cys-drug_1155|rdfs:comment|IgG1 - kappa - 4cys - drug imgt:G-ALPHA2-LIKE|skos:definition|G-LIKE domain similar to G-ALPHA2 of MH1, corresponding to domain 2 of I-ALPHA-LIKE chain imgt:StudyProduct_85864ad3-8f09-311e-8dd6-1b36987160d2|rdf:type|obo:NCIT_C174271 imgt:Segment_1189_1|imgt:has_rank|1 _:Bc7691881e5071c0b35e150ea506b4bb7|imgt:isDecidedBy|imgt:EMA imgt:Construct_226|obo:BFO_0000051|imgt:Segment_226_1 imgt:Product_042c8435-6492-3cdb-a685-d17d13c06937|imgt:comercial_name|RONAPREVE™ (casirivimab with imdevimab) imgt:StudyProduct_fe1cb031-da79-366d-895d-db414b0f301c|imgt:hasClinicalIndication|imgt:Cancers imgt:C2N_Diagnostics|rdfs:label|C2N Diagnostics imgt:Segment_584_1|rdf:type|imgt:Segment imgt:Construct_1263|imgt:isConstructOf|imgt:IgG4-kappa_1263 imgt:V-LAMBDA-VH-CH2-CH3|rdfs:label|V-LAMBDA-VH-CH2-CH3 imgt:IgG1-kappa_122|imgt:hasConstruct|imgt:Construct_122 imgt:Construct_376|rdf:type|imgt:Construct pubmed:7985542|dc:contributor|Padlan EA imgt:mAb_99|rdf:type|obo:NCIT_C1909 imgt:StudyProduct_a3800fc5-233c-3edd-bd1c-f42059b81c6a|rdf:type|obo:NCIT_C174271 imgt:ENZ-XTEN_700|rdf:type|imgt:MAbReceptor imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_d80656d3-6574-3674-9d8d-460d84f0d743 imgt:Construct_633|obo:BFO_0000051|imgt:Segment_633_1 imgt:Product_ecb3c0eb-db31-3f63-a0a2-a59c047defae|imgt:hasStudyProduct|imgt:StudyProduct_2314246e-4d62-3512-9c45-8393eff5d5e5 imgt:IgG1-kappa_1214|http://semanticscience.org/resource/SIO_000291|imgt:Severe_acute_respiratory_syndrome_coronavirus_2_(SARS-CoV-2) obo:SO_0000565|rdf:type|owl:Class 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imgt:IgG1-kappa_539|imgt:hasConstruct|imgt:Construct_539 imgt:IgG2-kappa_369|imgt:isMabReceptorOf|imgt:mAb_369 imgt:mAb_208|rdfs:label|mAb_208 imgt:mAb_1002|imgt:inn_number|11328 imgt:10257|imgt:isImgtStructureEntryOf|imgt:mAb_665 imgt:G-ALPHA1-LIKE|rdf:type|imgt:G-LIKE-DomainLabel pubmed:3025856|dc:contributor|Sun L.K. imgt:Product_2afcb1d2-59f0-3021-b52c-19a197ec5ec9|imgt:commun_name|HFB30132A imgt:CCL24|obo:RO_0002162|imgt:Homsap imgt:StudyProduct_c5074f11-9520-3726-bb53-f999c28df5fc|rdf:type|obo:NCIT_C174271 imgt:Product_972e9945-c489-3173-8e5c-a341bfd8de2d|imgt:isProductOf|imgt:mAb_1023 _:B042738076e46f8bf0bef89b796276b5a|imgt:isDecisionOf|imgt:StudyProduct_61df7cb6-fb76-3a96-81e3-f5f236bd6f47 imgt:Segment_1203_1|rdfs:label|Segment_1203_1 imgt:Product_73c81dcd-fbbc-38ac-a403-d4b47378e287|imgt:commun_name|MEDI-9447 imgt:Product_1d35d4a7-3f31-3f7c-bb34-858d027ec0c4|imgt:hasStudyProduct|imgt:StudyProduct_dbc35ff8-1e6e-3381-8154-ed33e47dc52d imgt:MAbReceptor_513|imgt:hasMolecularComponent|imgt:IG imgt:StudyProduct_a852befa-3965-32c2-8ca9-ec97d12ef5c3|imgt:hasDecision|_:B541b16c356e56812bb9ae0a1201231f2 _:B4ce7aa9a43c00972c7fea60e02b6696a|imgt:isDecisionOf|imgt:StudyProduct_cb7167ad-d7e4-3970-8752-f2a0b6b7e5e5 imgt:mAb_1245|imgt:inn_name|clesrovimab imgt:Construct_1056|imgt:isConstructOf|imgt:(scFv-heavy-kappa)-(scFv-heavy-lambda)_1056 imgt:AbbVie_Inc|imgt:produces|imgt:Product_9fe2aea9-6590-3730-92bb-c9b32d85d073 imgt:StudyProduct_731e0a81-9e68-35db-b84d-365665c4a62b|imgt:development_technology| MorphoSys's HuCAL® phage library imgt:mAb_963|imgt:inn_number|10938 imgt:Segment_598_1|imgt:has_rank|1 imgt:Product_8f2b525d-90b5-3eb3-92db-11b02305df48|rdfs:label|Product_8f2b525d-90b5-3eb3-92db-11b02305df48 imgt:StudyProduct_f375ecf3-18aa-381c-a6b2-03574a674c16|imgt:hasClinicalIndication|imgt:Autoimmune_disorders _:B49663518329f17996be34b42c344ff51|imgt:isDecisionOf|imgt:StudyProduct_2dd3404f-1979-37e2-9af4-6960a4e508ea 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imgt:Product_bf01e52c-681c-3e27-a65a-7e56b7753697|rdfs:label|Product_bf01e52c-681c-3e27-a65a-7e56b7753697 imgt:mAb_1201|rdf:type|imgt:INN imgt:CJSC_Biocad|imgt:produces|imgt:Product_fe4306e4-ad4c-324d-ba52-29c03d3c653f imgt:StudyProduct_f8e070f0-9178-373d-9d81-ffb46c539e03|imgt:hasExpressionSystem|imgt:_Hybridoma_murine_ascites imgt:Clone_1267|rdfs:label|Clone_1267 imgt:Product_8aab193e-5ea6-3d52-8519-ee1de15448f9|imgt:commun_name|ACT017 imgt:Clone_570|obo:RO_0002162|imgt:Musmus imgt:Segment_1280_1|rdfs:label|Segment_1280_1 imgt:mAb_632|imgt:inn_recommended_list|79 (2018) imgt:IgG2-kappa_376|imgt:isMabReceptorOf|imgt:mAb_376 imgt:mAb_1188|imgt:inn_recommended_list|87 (2022) imgt:CTLA4|imgt:isTargetOf|imgt:IgG1-kappa_1123 imgt:Product_4de55e77-7186-39d1-bc82-1a6d21e0c87a|imgt:isProductOf|imgt:mAb_982 imgt:mAb_303|imgt:hasMabReceptor|imgt:IgG2a-nd_303 imgt:Product_c0832524-e677-32cb-a464-95ca9d50cf44|imgt:hasStudyProduct|imgt:StudyProduct_ae30a3d1-32c8-3507-8e00-744436441b55 imgt:Construct_610|rdfs:label|Construct_610 imgt:mAb_75|rdf:type|obo:NCIT_C77862 imgt:StudyProduct_f8bbeacd-384d-348c-9082-d06e85699d5d|rdfs:label|StudyProduct_f8bbeacd-384d-348c-9082-d06e85699d5d imgt:StudyProduct_38c2a9dc-6699-34ae-b3c9-3eaac7d9b00f|imgt:hasClinicalPhase|imgt:Phase_I imgt:scFv-scFv-scFc_kappa-lambda_1055|imgt:isMabReceptorOf|imgt:mAb_1055 imgt:StudyProduct_8284c36a-a4f1-3679-8daa-5c500ee2284b|imgt:application_type|Therapeutic imgt:_Sp2/0_mouse_hybridoma_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_db8d8267-f336-3715-b038-38454987d7a7 imgt:IgG1-kappa_MM_541|imgt:hasMolecularComponent|imgt:IG imgt:mAb_328|rdf:type|imgt:INN imgt:Corvas_International_Inc|imgt:produces|imgt:Product_946b8f52-507d-3bbc-a1e3-51d4ec44415b imgt:mAb_413|rdf:type|imgt:INN imgt:Product_8c770a12-7fc2-32b8-8008-b740990cf3b1|imgt:isProducedBy|imgt:Nventa_Biopharmaceuticals_Corporation imgt:StudyProduct_02e6ed45-1e3c-3d4d-bdc7-e3ccfeb40215|imgt:hasClinicalPhase|imgt:Phase_M 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imgt:Product_5434bb15-0743-328f-bf03-72722410825d|imgt:hasStudyProduct|imgt:StudyProduct_66442d8f-2ea8-3e4e-b7bb-e1dd8b235ba0 imgt:Clone_845|imgt:clone_name|315-19 imgt:Product_8a0ac4eb-a8dd-3147-bc12-a4ce3c797eac|imgt:hasStudyProduct|imgt:StudyProduct_6c878ada-1306-3956-b6b2-ee886b0c2e29 imgt:mAb_538|rdf:type|imgt:INN imgt:CD74|skos:definition|CD74 (major histocompatibility class II invariant chain, MH2) imgt:humanized|rdfs:label|humanized imgt:L-V-D-J-C-sequence|protege:protege#subclassesDisjoint|true imgt:Construct|rdfs:subClassOf|obo:PR_000000001 imgt:Product_29ed30a2-7708-3212-b64a-672c17f2dab4|imgt:commun_name|AMG-412 imgt:StudyProduct_2d768be6-3423-3d2e-af4f-a92794541449|rdf:type|obo:NCIT_C174271 imgt:Construct_619|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Allergic_rhinitis|imgt:isClinicalIndicationOf|imgt:StudyProduct_741b2e1e-dbf1-328c-9a4a-1154d70ab9fd imgt:Clone_110|rdfs:label|Clone_110 imgt:Product_db54ace8-9d0d-3afe-8d6e-8dda791a352c|rdfs:label|Product_db54ace8-9d0d-3afe-8d6e-8dda791a352c imgt:StudyProduct_ad148a23-483e-36c3-a08d-6918c97fabc6|imgt:application_type|Therapeutic imgt:Cluster_headache_(CH)|rdf:type|obo:NCIT_C185637 imgt:StudyProduct_1b9cec3d-d541-35a3-ba0f-add2fb0637da|rdfs:label|StudyProduct_1b9cec3d-d541-35a3-ba0f-add2fb0637da imgt:nextTo|rdfs:subPropertyOf|obo:RO_0002220 imgt:IG-Heavy-Mu-IGHM|imgt:defines|imgt:IgM_Iota-1 imgt:Fab-Gamma-2-a_Kappa|rdfs:label|Fab-Gamma-2-a_Kappa imgt:N4-REGION|rdf:type|imgt:N-RegionLabel imgt:IgG1-kappa_MM_508|imgt:hasMolecularComponent|imgt:IG imgt:Segment_1022_1|imgt:has_rank|1 imgt:StudyProduct_343f38b9-8b03-3432-9450-062949ab34f9|imgt:hasExpressionSystem|imgt:_Adenovirus_transformed_human_embryonic_293_kidney_cells imgt:Construct_193|rdfs:label|Construct_193 imgt:Construct_311|rdf:type|imgt:Construct imgt:Product_5263e9de-956e-3cc5-9f06-d8273ad3417e|imgt:isProductOf|imgt:mAb_414 imgt:9567|rdfs:label|9567 imgt:StudyProduct_aaf88d47-e347-3a74-85df-c908aa9bede9|imgt:isStudyProductOf|imgt:Product_aaf2e2c9-1c88-3eed-ab99-9dbe7332094a imgt:FUSION-TNFRSF13B-GAMMA-1|skos:definition|TNFRSF13B fused with G1 H-CH2-CH3 imgt:Segment_325_1|rdfs:label|Segment_325_1 imgt:IgG1-kappa_806|imgt:hasMolecularComponent|imgt:IG imgt:mAb_625|rdf:type|obo:NCIT_C33987 imgt:Atrophy_muscle_wasting_disorders|rdfs:label|Atrophy_muscle_wasting_disorders imgt:Product_52d64598-ed50-3201-a067-7767d7a82e62|imgt:commun_name|ABT-806 imgt:StudyProduct_23e6cb85-b1f6-376c-a384-fd55c313f434|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_08c22142-db46-3298-b221-05fa460a0128|imgt:isStudyProductOf|imgt:Product_dedf2cda-9a79-3099-b41b-d4cfcb51cc21 imgt:Clone_570|imgt:clone_name|SC16 imgt:10787|imgt:isImgtStructureEntryOf|imgt:mAb_849 imgt:Product_483963c5-2edc-3412-9648-699e6b83a759|imgt:comercial_name|ENTYVIO™ imgt:Construct_704|imgt:hasImgtLabel|imgt:aldifitox:diphteriatoxin_(AB_toxin)_1-387-IL2_(interleukin_2_IL-2)_1-133 imgt:Segment_895_1|imgt:has_rank|1 imgt:CSF3R|rdfs:label|CSF3R imgt:Jiangsu_T-Mab_Biopharma_Co_Ltd|rdfs:comment|Taizhou , China imgt:Construct_813|rdf:type|imgt:Construct imgt:IG-MU_IOTA-1|skos:definition|IG receptor comprising two H-MU and two L-IOTA-1 chains _:Baca96eeebb58a852d170466a1e2cb220|dc:date|2012-09-28 imgt:Product_4a797e84-8295-30a5-8686-ca6de1774780|imgt:hasStudyProduct|imgt:StudyProduct_6a51865b-a2bb-3a85-9e96-4a425b1806c1 imgt:StudyProduct_062c20ec-d304-30b1-9eec-ad060650ce0b|rdf:type|obo:NCIT_C174271 imgt:IgG1-kappa_931|imgt:hasMolecularComponent|imgt:IG imgt:Construct_235|rdf:type|imgt:Construct imgt:Fab-Gamma-2_Lambda|imgt:isDefinedBy|imgt:IG-Light-Lambda-IGL imgt:Segment_895_2|obo:BFO_0000050|imgt:Construct_895 imgt:Construct_1230|rdf:type|imgt:Construct imgt:IL21|rdfs:label|IL21 imgt:Clone_152|imgt:isOriginCloneOf|imgt:mAb_152 imgt:IgG1-kappa_589|imgt:isMabReceptorOf|imgt:mAb_589 imgt:StudyProduct_990d9537-fad6-3727-a623-6279efbdf49a|imgt:isStudyProductOf|imgt:Product_89673b25-e6b7-3aef-bb38-c080848cfbaa imgt:mAb_1146|imgt:imgt_note| WHO Drug Information, Vol. 34, No. 3, 2020. Proposed INN List 124 – COVID-19 (special edition) (9 October 2020) pages 642-669. Proposed INN List 124 (19 December 2020, published on 22 January 2021) pages 929-1102. pubmed:20848453|dc:contributor|de Jong DJ imgt:Segment_363_1|rdfs:label|Segment_363_1 imgt:IgG1-kappa-4cys-drug_1269|rdf:type|imgt:MAbReceptor _:B363cbe14f3fe3f4eac7d9e31c2df130f|dc:date|2019-11-15 _:B82d3eb42cf786219cf31f7520182677e|dc:date|2015-11-24 imgt:mAb_1072|imgt:hasProduct|imgt:Product_19a1534c-6a6d-3e36-8e22-4f68fcf59ddf imgt:Cancers_colorectal_(CRC)|imgt:isClinicalIndicationOf|imgt:StudyProduct_a19c7e6d-dacb-3962-ad32-ab8dfbf103b1 imgt:mAb_1227|imgt:hasOriginClone|imgt:Clone_1227 imgt:StudyProduct_e06afffa-6987-340f-9384-e5858396259c|rdfs:label|StudyProduct_e06afffa-6987-340f-9384-e5858396259c imgt:Segment_1016_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:IGM_Biosciences_Inc|rdfs:label|IGM Biosciences, Inc. imgt:StudyProduct_a3d811c7-3f8e-37fd-a8ff-b4da7dcc59a3|imgt:hasClinicalPhase|imgt:Phase_M imgt:IgG1-kappa_855|obo:RO_0002162|imgt:Musmus imgt:Product_5ce3b46d-9c42-34a1-a25d-2571a2d48a7a|imgt:hasStudyProduct|imgt:StudyProduct_e830e5de-f880-323f-a30f-b17d9e9b6a9e imgt:LIB_Therapeutics_LLC|rdfs:comment|Cincinnati , USA imgt:Product_3fbfe977-f5f9-381b-94d0-489e229f2eaf|imgt:hasStudyProduct|imgt:StudyProduct_f9c255ee-bf15-3e1d-8e12-8640727c6eae imgt:mAb_1090|imgt:inn_recommended_list|85 (2021) imgt:KDR|obo:RO_0002162|imgt:Homsap imgt:Product_900b5056-b55a-35e7-a10a-bb0aa9603a51|rdf:type|obo:NCIT_C51980 imgt:Construct_523|rdfs:label|Construct_523 imgt:mAb_1117|rdfs:label|mAb_1117 imgt:StudyProduct_c47859a9-7323-3b02-9b97-441848f91191|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:%5BACVR2B_(activin_A_receptor_type_2B_ActR-IIB_ActRIIB)%5D2-IGHG1_Fc_(Fragment_constant)|rdfs:label|[ACVR2B (activin A receptor type 2B, ActR-IIB, ActRIIB)]2 - IGHG1 Fc (Fragment constant) imgt:Segment_545_2|imgt:has_rank|2 imgt:Construct_694|imgt:hasImgtLabel|imgt:F7_(coagulation_factor_VII_coagulation_serum_prothrombin_conversion_accelerator)-ALB_(albumin_human_serum_albumin_HSA)_25-609 imgt:StudyProduct_fc5cc4ff-cd79-3360-ba2c-9cb8a2518a23|imgt:hasDecision|_:B68929fa587f49ae1e6aa3f2c9b06f209 imgt:Product_e1755688-f5bf-394d-ad74-9e20fb42396c|imgt:commun_name|H52 _:B2ec2909e8fc9de28ee640e6956657a7b|imgt:hasStatut|imgt:approval _:B6b5c24242167703262af7fb8bd914a16|rdf:type|obo:NCIT_C53285 imgt:Segment_591_1|imgt:has_rank|1 pubmed:10960454|dc:contributor|Shouval D imgt:MAbReceptor_63|imgt:isMabReceptorOf|imgt:mAb_63 imgt:StudyProduct_6e03627b-b36a-3077-933f-f5e2f57886fb|imgt:hasClinicalPhase|imgt:Phase_II imgt:Product_3f969fb2-2f38-3306-95e8-3b31282d0786|imgt:commun_name|SPV-T3a imgt:StudyProduct_be878d4b-19f2-35fc-9038-5fbf733ae943|imgt:application_type|Therapeutic imgt:StudyProduct_1bd1f357-adce-3f38-b965-daef051d4331|imgt:hasClinicalIndication|imgt:Cancers_small_cell_lung_(SCLC) pubmed:10960454|dc:contributor|Eren R obo:NCIT_C171835|rdfs:subClassOf|obo:NCIT_C1909 imgt:Product_f246242d-cc24-305b-8e9f-06e04804a59b|rdfs:label|Product_f246242d-cc24-305b-8e9f-06e04804a59b imgt:NCAM1|imgt:isTargetOf|imgt:MAbReceptor_211 imgt:StudyProduct_e7ccbaca-89b8-33e8-962f-c19741fda74e|imgt:application_type|Therapeutic imgt:mAb_271|imgt:hasOriginClone|imgt:Clone_271 imgt:Opthea|rdfs:comment|South Yarra , Australia imgt:mAb_797|rdf:type|imgt:INN imgt:IgG4-kappa_1002|rdfs:label|IgG4-kappa_1002 imgt:Psoriasis|imgt:clinical_domain|Immunology imgt:IgG1-kappa_406|obo:RO_0002162|imgt:Hum imgt:Neutropenia_chemotherapy-induced|imgt:isClinicalIndicationOf|imgt:StudyProduct_60dfa53b-3345-3e41-ac21-3e5522a41ada imgt:IgM-kappa_scFv-heavy-kappa_1257|rdfs:comment|IgM-kappa_scFv-heavy-kappa imgt:StudyProduct_b07cddb6-dde6-357b-8183-6c0a9d745fc5|imgt:application_type|Therapeutic _:B0e673e981fc9cc9ff6ce9c6c08306e54|rdf:type|obo:NCIT_C53285 imgt:Segment_264_2|imgt:has_rank|2 imgt:StudyProduct_a186afa2-4718-3a82-81f9-640ec7c1cc30|imgt:application_type|Therapeutic imgt:Product_5f1c9bc2-bf3c-3926-b576-52dfce1082d7|imgt:commun_name|ACE-083 imgt:FPIA_%5BPROTEIN_4REPEATS%5D2-3S-FC_733|imgt:hasMolecularComponent|imgt:FPIA imgt:Construct_335|imgt:hasImgtLabel|imgt:IgG4-lambda2 imgt:StudyProduct_b11269fe-e332-3368-a43f-122b11dfc8db|rdfs:label|StudyProduct_b11269fe-e332-3368-a43f-122b11dfc8db imgt:mAb_243|rdfs:label|mAb_243 imgt:StudyProduct_bfb2e54a-e89b-3b48-b84d-cdbd91007b2d|rdfs:label|StudyProduct_bfb2e54a-e89b-3b48-b84d-cdbd91007b2d imgt:StudyProduct_6d2b9607-0f54-334f-9a71-2538aca2b433|imgt:hasClinicalPhase|imgt:Preclinical imgt:Product_087106c8-1d20-3672-9d32-bc8b102b16ae|imgt:isProducedBy|imgt:MRC_Technology imgt:Product_ef773100-576d-3e97-97eb-e28da2eb7a6d|rdf:type|obo:NCIT_C51980 imgt:Segment_1196_1|imgt:hasImgtLabel|imgt:IgG1-kappa _:Bb2429c6ca616cb6226067307ae0f654e|dc:date|2020-01-15 imgt:StudyProduct_95c081f3-ed01-3b7d-b6eb-1bbe64bc37ee|imgt:hasClinicalIndication|imgt:Ischemic_stroke imgt:Clone_125|imgt:clone_name|LL2 (IgG2a) imgt:Dementia_Alzheimer_s_type|rdfs:label|Dementia_Alzheimer_s_type obo:NCIT_C163022|rdfs:subClassOf|obo:NCIT_C1909 obo:NCIT_C152483|rdf:type|owl:Class imgt:StudyProduct_da25047e-345c-3792-b89f-73042c019bf0|imgt:application_type|Therapeutic imgt:EGFR|imgt:isTargetOf|imgt:VK-CK-VH-CH1-h-CH2-CH3_L-kappa_Fab-G1-kappa_1207 imgt:humanized|rdfs:comment| or synthetic) whereas the remaining chain is of human origin. By extension an antibody is described as humanized if more recent protocoles were used for the humanization. imgt:IgG1-kappa_283|obo:RO_0002162|imgt:Hum imgt:mAb_235|imgt:hasImgtStructureEntry|imgt:8864 imgt:Segment_387_1|rdf:type|imgt:Segment imgt:Segment_258_1|imgt:has_rank|1 imgt:IgG4-lambda_1071|rdfs:label|IgG4-lambda_1071 imgt:StudyProduct_43590e3c-59b5-3c5d-82b1-a9201d56edc4|imgt:isStudyProductOf|imgt:Product_75a2ea16-7c01-33b5-99ec-50f47304f68d imgt:Medarex|imgt:produces|imgt:Product_c311e57b-5fdf-3259-ae3a-0eab5583a035 imgt:Construct_865|rdfs:label|Construct_865 imgt:Lymphoma_cutaneous_T_cell_(CTCL)|imgt:clinical_domain|Oncology imgt:Product_527cd5df-73d5-3032-9885-15b54f61e5ba|imgt:isProductOf|imgt:mAb_506 imgt:mAb_197|imgt:inn_recommended_list|35 (1995) imgt:CGB3|rdfs:label|CGB3 imgt:StudyProduct_67b4a783-fc65-3bcf-b44d-b3473880441d|rdfs:label|StudyProduct_67b4a783-fc65-3bcf-b44d-b3473880441d imgt:Product_232542fe-0287-33f1-8c7e-20ab57876db6|imgt:isProducedBy|imgt:Massachusetts_Biologic_Laboratories imgt:mAb_229|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=229 imgt:Product_64290ba9-0505-3e73-bd11-364751196aba|rdf:type|obo:NCIT_C51980 imgt:Idiopathic_pulmonary_fibrosis|imgt:isClinicalIndicationOf|imgt:StudyProduct_76ee9841-a655-331c-a8ef-8ffe48ebe5fc _:Bcc1bca32f76981f1b728b185b17c598c|dc:date|2017-09-20 imgt:_Hybridoma_murine_ascites|imgt:isExpressionSystemOf|imgt:StudyProduct_980c504c-20da-34f2-8e0d-9812491b4e8b imgt:Segment_1036_1|rdfs:label|Segment_1036_1 imgt:CPCA_three-helical_bundle_1046|rdfs:comment|CPCA_three-helical bundle imgt:mAb_600|imgt:hasImgtStructureEntry|imgt:10236 imgt:Product_12795352-592b-3769-b822-3a051d3b326d|imgt:commun_name|muMAb VEGF A.4.6.1 _:B503c74e9c461c4992ecc3fb8410896df|imgt:isDecisionOf|imgt:StudyProduct_c3a58be7-6f2c-3796-84c1-70f8564ad24a imgt:mAb_402|rdfs:label|mAb_402 imgt:mAb_951|imgt:hasProduct|imgt:Product_f7538e81-df8d-3950-8fd5-c3ef71a52d77 imgt:mAb_883|imgt:hasMabReceptor|imgt:IgG1-nd_883 imgt:mAb_579|imgt:hasMabReceptor|imgt:IgG4-kappa_579 imgt:Construct_1228|rdfs:label|Construct_1228 imgt:IgG4-kappa_807|imgt:hasMolecularComponent|imgt:IG imgt:mAb_1185|imgt:inn_recommended_list|87 (2022) imgt:Product_c6e625a6-b97d-3e44-9c4f-6b949cd3d815|imgt:isProductOf|imgt:mAb_206 imgt:Product_12494fab-b8e7-3c2d-8bff-66f5e59682b8|rdf:type|obo:NCIT_C51980 imgt:mAb_179|imgt:hasProduct|imgt:Product_2527517c-0a7a-3f6a-b4c5-fff6e5f2d499 imgt:Product_7b218984-827b-308c-b071-1543ff27916b|imgt:isProductOf|imgt:mAb_85 imgt:StudyProduct_5fd82fcb-b163-3742-9246-bea610f85fff|rdf:type|obo:NCIT_C174271 imgt:University_of_California|rdf:type|obo:NCIT_C54131 imgt:StudyProduct_b95b0186-bd43-39ff-8924-e9e5390db2ff|imgt:isStudyProductOf|imgt:Product_a67505b3-33ab-373f-8cc4-0f19a5a0e8ab imgt:G|rdfs:label|germline imgt:StudyProduct_41b94ce1-b65d-37bc-aa0f-a71002c3a9ae|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:Segment_819_2|imgt:has_rank|2 imgt:Product_a906e8c2-5cd0-31d0-9f46-849a19d4b85b|imgt:isProducedBy|imgt:AstraZeneca imgt:Janssen_Biotech_Inc|imgt:produces|imgt:Product_b4ab3c62-24b2-3d64-b784-2e7b8f08aeb2 imgt:StudyProduct_822e0dff-2194-32df-bf81-33ffe7d06102|imgt:application_type|Therapeutic imgt:Glaucoma_surgery|rdfs:label|Glaucoma_surgery imgt:Construct_544|imgt:isConstructOf|imgt:IgG1-kappa_544 imgt:IgG1-nd_45|imgt:isMabReceptorOf|imgt:mAb_45 imgt:adenocarcinoma_antigen|rdfs:label|adenocarcinoma antigen imgt:decavalent|rdfs:label|decavalent imgt:F7|rdfs:label|F7 imgt:Product_8ebb651d-8c4b-3d4f-b003-59fa4adb7ac7|imgt:commun_name|CEA TCB imgt:mAb_151|imgt:hasImgtStructureEntry|imgt:5ESQ imgt:StudyProduct_024b4b67-b3a6-3886-a04b-f0a3feef3807|imgt:application_type|Therapeutic imgt:mAb_962|imgt:hasImgtStructureEntry|imgt:11035 imgt:Segment_1048_2|obo:BFO_0000050|imgt:Construct_1048 imgt:EGFR|imgt:isTargetOf|imgt:IgG1-kappa-4cys-drug_645 imgt:StudyProduct_e2e0e4e8-186e-366d-bf96-3cdbf085e738|rdfs:label|StudyProduct_e2e0e4e8-186e-366d-bf96-3cdbf085e738 imgt:Product_b9e8379b-d30f-37fb-ac2e-44ad77f3f669|rdfs:label|Product_b9e8379b-d30f-37fb-ac2e-44ad77f3f669 imgt:Product_d9212299-036c-39af-b29c-31d7fe01268c|rdfs:label|Product_d9212299-036c-39af-b29c-31d7fe01268c imgt:StudyProduct_a5041f6f-38ad-36eb-8be8-2917d0dd8a6b|imgt:hasDecision|_:B1b1f6d8619a28a8b65ef36792f784c6b imgt:mAb_338|rdfs:label|mAb_338 imgt:mAb_282|imgt:inn_recommended_list|46 (2001) imgt:StudyProduct_f9ebad83-378a-39ab-9408-576c062cfcdf|rdfs:label|StudyProduct_f9ebad83-378a-39ab-9408-576c062cfcdf _:Ba166c0b97e46582cfe441bceee6c3091|rdf:type|obo:NCIT_C53285 imgt:StudyProduct_b12799c4-4250-3cf5-9055-370a69eac085|rdfs:label|StudyProduct_b12799c4-4250-3cf5-9055-370a69eac085 _:B7f7ad4640905631adec4a7b46ced73be|imgt:isDecidedBy|imgt:FDA imgt:Product_bae50c2e-31d7-37c8-b66f-d31a9fa0b189|imgt:isProductOf|imgt:mAb_608 imgt:Construct_540|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:hasClinicalPhase|rdfs:range|http://purl.org/net/OCRe/study_design.owl#OCRE100038 imgt:Construct_1020|rdfs:label|Construct_1020 obo:NCIT_C130050|rdf:type|owl:Class _:B0d142fb694757537ad781320238b8791|imgt:hasStatut|imgt:approval imgt:Segment_1049_1|obo:BFO_0000050|imgt:Construct_1049 imgt:Segment_895_1|obo:BFO_0000050|imgt:Construct_895 imgt:Paroxysmal_nocturnal_hemoglobinuria_(PNH)|rdfs:label|Paroxysmal_nocturnal_hemoglobinuria_(PNH) imgt:IgG1-kappa_1110|imgt:isMabReceptorOf|imgt:mAb_1110 imgt:IgG1-kappa_1080|obo:RO_0002162|imgt:Hum imgt:Product_96fc911e-455e-31e8-853b-3466ad4672d0|imgt:hasStudyProduct|imgt:StudyProduct_1a64ef25-30ed-3988-9d19-9bfcc5d21705 imgt:StudyProduct_5511d3d8-82d2-35ce-8b66-66e212033b67|imgt:hasClinicalPhase|imgt:Phase_II _:B99bf22748b3bf818087a676a483ae990|imgt:hasDesignation|imgt:Orphan_drug imgt:Construct_1289|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Nektar_Therapeutics|imgt:produces|imgt:Product_218005ef-16bd-34ee-970f-6ed51853e661 _:B75ffb1762de0577815ea9a04ae099fed|dc:date|2001-12-05 imgt:mAb_591|imgt:inn_name|refanezumab imgt:StudyProduct_40b274c9-cbce-3d0d-9e45-f57a914447eb|imgt:application_type|Therapeutic imgt:mAb_1222|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=1222 imgt:Clone_121|imgt:isOriginCloneOf|imgt:mAb_121 imgt:Segment_231_1|imgt:has_rank|1 imgt:Construct_1051|obo:BFO_0000051|imgt:Segment_1051_1 imgt:Product_689cd79f-29d1-3d43-bdd9-edb405308805|imgt:commun_name|DLX105 imgt:11887|imgt:isImgtStructureEntryOf|imgt:mAb_1234 imgt:VH-VH%27_1253|rdfs:comment|VH - VH' imgt:StudyProduct_b9490482-f599-3976-bddb-2fd9f2677311|imgt:application_type|Therapeutic imgt:10440|imgt:isImgtStructureEntryOf|imgt:mAb_717 imgt:mAb_1230|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=1230 imgt:mAb_3|imgt:clinical_trials|7 studies found, 3 recruiting imgt:mAb_101|imgt:inn_number|9028 imgt:StudyProduct_c8410db6-e214-3133-9a26-8eee32338034|imgt:hasClinicalIndication|imgt:Melanoma imgt:IgG2-kappa_116|rdfs:comment|IgG2 - kappa _:B97b332decbf3727cb48f7c2a92d50a0b|imgt:isDecidedBy|imgt:FDA imgt:Segment_176_1|rdf:type|imgt:Segment imgt:mAb_111|imgt:hasImgtStructureEntry|imgt:8659 imgt:Segment_440_1|imgt:has_rank|1 imgt:Segment_588_1|rdf:type|imgt:Segment imgt:Product_2bfb276f-0cd4-3496-a28f-c9af723650c0|imgt:isProducedBy|imgt:Amgen imgt:StudyProduct_02a5d74c-0f83-3ab4-bf1e-8261d9c461d3|imgt:hasClinicalIndication|imgt:Organ_transplant_immunological_rejection_suppression imgt:StudyProduct_6ba65a28-3657-3e97-b336-766e043f01f2|imgt:isStudyProductOf|imgt:Product_94a274de-ded8-3d8a-9d04-5df215c7d578 imgt:IG-MU_IOTA-4|imgt:describes|imgt:IgM_Iota-4 imgt:Product_d6b7487b-6d4c-3cd4-8d1a-5ffd835eec19|imgt:isProducedBy|imgt:TRION_Pharma imgt:10873|rdfs:label|10873 imgt:mAb_548|imgt:hasOriginClone|imgt:Clone_548 imgt:IgG1-kappa-4cys-drug_814|rdfs:label|IgG1-kappa-4cys-drug_814 imgt:Product_73163992-bca3-3133-8e3d-bb21f7359d0d|imgt:commun_name|hu14.18-Interleukin-2 fusion protein imgt:L-V-J-C-chain|rdf:type|imgt:Molecule_EntityType imgt:AXL|imgt:isTargetOf|imgt:IgG1-kappa-4cys-drug_814 imgt:_CHO-K1|imgt:isExpressionSystemOf|imgt:StudyProduct_be59984e-2e11-35c7-91d3-05fc86caef5e imgt:StudyProduct_a3cab484-8214-32df-9ddb-3afe5e6bfd92|imgt:hasClinicalIndication|imgt:B_cell_leukemia imgt:Construct_411|rdfs:label|Construct_411 obo:NCIT_C152149|rdf:type|owl:Class _:B4ce7aa9a43c00972c7fea60e02b6696a|imgt:isDecidedBy|imgt:FDA pubmed:30713784|dc:contributor|Pumphrey NJ imgt:Construct_251|rdf:type|imgt:Construct imgt:Canlupfam_CD52|rdf:type|obo:NCIT_C25702 imgt:Product_4a4c4d40-304a-3d8a-bef8-533a579b445d|imgt:isProductOf|imgt:mAb_248 imgt:mAb_1250|rdf:type|imgt:INN imgt:Product_480f91be-f048-34a5-9224-9a68a0291dd8|imgt:commun_name|UTTR-1147A imgt:Construct_1048|obo:BFO_0000051|imgt:Segment_1048_1 imgt:IgG1-lambda_323|imgt:isMabReceptorOf|imgt:mAb_323 imgt:mAb_488|imgt:inn_number|9832 imgt:StudyProduct_e3ec4548-ebf9-3671-b2a8-b6d058299fab|imgt:hasClinicalIndication|imgt:Idiopathic_pulmonary_fibrosis imgt:Segment_153_1|rdf:type|imgt:Segment imgt:StudyProduct_191b0336-8bbf-3389-a634-8bdc89173b72|imgt:hasDecision|_:Bfbd72133cbc3df9460c7bc530e2451c7 imgt:StudyProduct_762a821f-05df-3208-85ab-be3f6eb0f4ee|imgt:development_technology| MorphoSys's HuCAL® phage library imgt:StudyProduct_300d8bb5-c675-3ea9-9f98-67e2fc5149f0|rdfs:label|StudyProduct_300d8bb5-c675-3ea9-9f98-67e2fc5149f0 imgt:StudyProduct_d326469e-6f88-3537-a40c-8ab4d0953fec|imgt:application_type|Therapeutic imgt:Segment_806_1|obo:BFO_0000050|imgt:Construct_806 imgt:StudyProduct_df2b1eee-0658-3294-a5a9-6de278413282|imgt:hasClinicalIndication|imgt:Cancers_pancreatic imgt:Neuromyelitis_optica_spectrum_disorder_(NMOSD)|imgt:isClinicalIndicationOf|imgt:StudyProduct_0aebb790-3d06-323b-ab0d-ca38d16cb29a imgt:mAb_922|imgt:hasProduct|imgt:Product_8cb056a9-1bba-3779-8ebf-14d74dfd6f63 imgt:IgG1-kappa_454|http://semanticscience.org/resource/SIO_000291|imgt:RTN4 imgt:StudyProduct_d08a20b2-9c23-3e4f-a00b-6f83c51732a6|imgt:development_technology| VelocImmune® imgt:IgG1-kappa_1070|obo:RO_0002162|imgt:Chi imgt:StudyProduct_90ded528-5aeb-3f2f-ad4a-9fc2f1cbaa5c|imgt:hasClinicalIndication|imgt:Myasthenia_Gravis_(MG) imgt:Novartis|imgt:produces|imgt:Product_8668df94-5bb9-3841-9139-21b5b8a00b95 imgt:mAb_1085|rdf:type|imgt:INN imgt:IgG1-kappa_1151|http://semanticscience.org/resource/SIO_000291|imgt:RGMA imgt:StudyProduct_c00b17bc-9bad-3ae7-bfac-076fc03a4d35|imgt:isStudyProductOf|imgt:Product_2bfb276f-0cd4-3496-a28f-c9af723650c0 imgt:TNF-α_receptor_I|skos:definition|TNF-α receptor I imgt:StudyProduct_8a37a7cb-7e65-308f-977a-9b6b8729759e|imgt:isStudyProductOf|imgt:Product_ac463e51-a20f-3d01-8147-23363a9d455e imgt:mAb_1177|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=1177 imgt:StudyProduct_8fafb39d-a882-31f1-80c7-29f8cbf3627b|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_faac2e57-fc8e-322b-b5e6-e0ba34ef089f|imgt:hasClinicalPhase|imgt:Discontinued imgt:scFv-scFv-scFc_kappa-lambda_1249|rdfs:comment|scFv-scFv-scFc_kappa-lambda obo:NCIT_C117729|rdf:type|owl:Class imgt:mAb_703|rdfs:label|mAb_703 imgt:StudyProduct_96f46e52-e9a8-3eeb-8b87-64e1abc367fe|rdfs:label|StudyProduct_96f46e52-e9a8-3eeb-8b87-64e1abc367fe imgt:chromosome-number|rdfs:label|chromosome-number imgt:StudyProduct_3a8557c2-af91-375e-9476-72214852a437|rdfs:label|StudyProduct_3a8557c2-af91-375e-9476-72214852a437 imgt:SORT1|imgt:isTargetOf|imgt:IgG1-kappa_1130 pubmed:25788700|dc:contributor|Sjögren T imgt:Clone_215|imgt:isOriginCloneOf|imgt:mAb_215 _:Bab2128b38c7479f7fcad5c220e0d6232|imgt:hasStatut|imgt:approval imgt:Genmab_A/S|imgt:produces|imgt:Product_6749bce5-ca17-3a1e-b6a6-716da8fc041b imgt:StudyProduct_e3cbe99d-6000-3501-9d16-4174cd95c02e|imgt:hasClinicalPhase|imgt:Phase_II imgt:11947|rdfs:label|11947 imgt:IgG2-lambda_448|obo:RO_0002162|imgt:Homsap imgt:Segment_487_2|rdfs:label|Segment_487_2 imgt:Fab-G1-kappa_84|http://semanticscience.org/resource/SIO_000291|imgt:VEGFA imgt:Product_a0ad7eed-cb27-395a-a42a-66344074cbf9|imgt:commun_name|MLN0002 imgt:StudyProduct_cc62fbde-9763-3acc-84ea-d3a40efa698d|rdfs:label|StudyProduct_cc62fbde-9763-3acc-84ea-d3a40efa698d obo:NCIT_C80044|rdfs:subClassOf|obo:NCIT_C1909 imgt:Product_7547be12-737a-3e6a-82f2-436c48142632|imgt:isProducedBy|imgt:Biocon imgt:mAb_111|imgt:nci_drug_dictionary_link|http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=299488 imgt:mAb_295|imgt:clinical_trials|126 studies found, 49 recruiting imgt:VH-VH|rdfs:label|VH-VH imgt:%5BNGR_peptide_1-6-TNF_(tumor_necrosis_factor_(TNF)_superfamily_member_2_TNFSF2_TNF-alpha_TNFA)%5D-trimer|imgt:construction_detail|Fusion - [NGR peptide 1-6 - TNF (tumor necrosis factor (TNF) superfamily member 2, TNFSF2, TNF-alpha, TNFA)] - trimer imgt:half-G1-kappa_scFv-HEAVY-LAMBDA-h-CH2-CH3_919|imgt:hasMolecularComponent|imgt:IG imgt:mAb_360|rdf:type|obo:NCIT_C80045 obo:NCIT_C174271|rdfs:subClassOf|obo:NCIT_C51980 imgt:G1-kappa_scFv-HEAVY-KAPPA-h-CH2-CH3_1084|imgt:hasMolecularComponent|imgt:IG imgt:StudyProduct_6ef39983-dbe2-33d9-a221-ce67c4fa0550|imgt:hasClinicalIndication|imgt:Cancers imgt:StudyProduct_adaf11b0-1c27-3356-adb2-13c0a8ccf2cc|imgt:isStudyProductOf|imgt:Product_ecd571df-a174-39e9-b5a2-5297330de6a7 _:B362696f678844df0a238d66f17d97816|imgt:isDecidedBy|imgt:FDA imgt:Segment_812_1|obo:BFO_0000050|imgt:Construct_812 imgt:Construct_193|imgt:hasImgtLabel|imgt:IgM-kappa imgt:Segment_1199_1|imgt:has_rank|1 imgt:mAb_380|rdfs:label|mAb_380 imgt:StudyProduct_262a7474-b842-354e-9a7f-3b5d9c0e45d6|rdf:type|obo:NCIT_C174271 imgt:Clone_8|obo:RO_0002162|imgt:Homsap imgt:Product_dedf2cda-9a79-3099-b41b-d4cfcb51cc21|rdf:type|obo:NCIT_C51980 imgt:StudyProduct_68e8a80f-02f1-37fa-acb5-e1842c42cfaf|imgt:isStudyProductOf|imgt:Product_7832c9e8-c4d7-3ca7-8c44-6880985116a0 imgt:Construct_626|obo:BFO_0000051|imgt:Segment_626_1 imgt:StudyProduct_1d4aa306-6821-3719-8f13-e1bab47134c8|imgt:hasClinicalIndication|imgt:Primary_progressive_multiple_sclerosis_(PPMS) imgt:MAGEA10|imgt:isTargetOf|imgt:BETA-ALPHA1_987 imgt:CHSD|skos:definition|duplicated CHS exon of IG heavy C-GENE in gDNA(found in teleostei), or CHSD region in cDNA imgt:Construct_373|rdf:type|imgt:Construct imgt:StudyProduct_4e0694fb-ee8d-3a3e-8aff-728d410b3829|rdf:type|obo:NCIT_C174271 imgt:mAb_6|imgt:hasBibliographicReference|pubmed:7937713 imgt:Segment_477_2|obo:BFO_0000050|imgt:Construct_477 imgt:Construct_1016|rdf:type|imgt:Construct _:Bae752d02491bdea2a6d49eafada35768|imgt:hasStatut|imgt:approval obo:NCIT_C107678|rdfs:subClassOf|obo:NCIT_C1909 _:Ba841730817b8144284d672dd08d9cd06|rdf:type|obo:NCIT_C53285 imgt:StudyProduct_3713f3fb-8ee7-3050-ab44-1f50b9aa2bb6|imgt:hasClinicalIndication|imgt:Dermatomyositis imgt:Product_736e7801-d395-37e7-97ba-6a0f2e81dbaa|imgt:hasStudyProduct|imgt:StudyProduct_6ffb2b85-8092-311b-a673-e688b57d2bf6 imgt:mAb_1140|imgt:hasOriginClone|imgt:Clone_1140 imgt:Segment_872_3|obo:BFO_0000050|imgt:Construct_872 obo:NCIT_C151967|rdfs:subClassOf|obo:NCIT_C1909 imgt:IgG4-kappa_809|imgt:hasMolecularComponent|imgt:IG imgt:StudyProduct_ee00fd15-4396-3146-9aa4-d1dc63eeb3c2|imgt:hasDecision|_:Be97a19e2e94d2d8bee9ba91f096981fe _:B28e143124171a2016dec4e580e494853|rdf:type|obo:NCIT_C53285 imgt:IgG1-kappa_1012|http://semanticscience.org/resource/SIO_000291|imgt:CD40 imgt:bispecific|imgt:isTargetOf|imgt:scFv-scFv-scFc_kappa-lambda_1074 imgt:StudyProduct_5a1ad1e9-3be1-3c12-9469-e6961e41c78a|imgt:hasClinicalIndication|imgt:Hepatitis_B imgt:Product_ad630571-be3a-37d0-b30d-5b4667c2c49a|imgt:isProductOf|imgt:mAb_742 imgt:mAb_397|rdf:type|obo:NCIT_C78128 imgt:University_of_Saskatchewan|rdfs:comment|Saskatchewan , Canada _:B1129e1d3102232ec22c0125b6eaa45f1|imgt:isDecisionOf|imgt:StudyProduct_27c8d894-d57d-3373-ab92-3279a037a393 imgt:8941|imgt:isImgtStructureEntryOf|imgt:mAb_230 imgt:1V-1C-LIKE_1V-LIKE|rdfs:label|1V-1C-LIKE_1V-LIKE imgt:StudyProduct_dbf9c186-16b6-3efe-bf6e-d1dc4dd0f50c|rdfs:label|StudyProduct_dbf9c186-16b6-3efe-bf6e-d1dc4dd0f50c imgt:Product_5bdd4781-1f7e-3d2a-a7f9-bebb5a59b8db|imgt:isProductOf|imgt:mAb_943 imgt:IG-Light-Lambda-IGL|imgt:defines|imgt:IgD_Lambda imgt:(scFv-kappa-heavy)-(scFv-kappa-heavy)|imgt:construction_detail|(scFv - kappa - heavy) - (scFv - kappa - heavy) imgt:StudyProduct_8d1e80ad-2d19-39df-9c52-05dbade259d0|imgt:hasClinicalIndication|imgt:Psoriasis imgt:Product_555d6702-c950-3cb7-a9a9-66504af0a635|imgt:isProductOf|imgt:mAb_239 imgt:10441|rdf:type|obo:NCIT_C25402 imgt:StudyProduct_b33accaf-1376-39fd-94a7-e730159c9736|imgt:hasDecision|_:Bff8a9c5a8d2b44cd87112738140acfb2 imgt:5-TNFR-CYS-GAMMA-1|rdfs:label|5-TNFR-CYS-GAMMA-1 imgt:StudyProduct_93e521f0-51b9-39b3-9dc8-3a9b52d70702|imgt:hasClinicalIndication|imgt:Type_1_diabetes imgt:Segment_777_1|imgt:has_rank|1 imgt:KS_Biomedix_Ltd|rdf:type|obo:NCIT_C54131 imgt:MAbReceptor_59|rdfs:label|MAbReceptor_59 imgt:Product_b2895cfe-5c84-354a-bccf-c88c0e46a211|rdf:type|obo:NCIT_C51980 imgt:MH2-BETA-PEPTIDE|imgt:describes|imgt:MH2-Beta-peptide imgt:StudyProduct_8405743a-9a21-385b-a81a-5dba154058ef|rdfs:label|StudyProduct_8405743a-9a21-385b-a81a-5dba154058ef imgt:Product_ac2f83a3-8f56-337f-9700-8fd94c18585e|imgt:commun_name|JNJ-64304500 imgt:StudyProduct_45e73f84-442e-3c10-b0db-af834591fbfc|rdfs:label|StudyProduct_45e73f84-442e-3c10-b0db-af834591fbfc imgt:StudyProduct_7d89203d-92fb-39aa-bf64-5c9f9bd8a413|imgt:isStudyProductOf|imgt:Product_e9e52bcc-24ec-39dc-8de4-b4ba591c6845 imgt:mAb_855|imgt:inn_number|10803 imgt:Product_691a766e-3d58-36e0-8d0f-f9070665bc53|imgt:commun_name|514-G-3 imgt:StudyProduct_d492924c-a2a3-326f-b523-5710d41d12a6|rdf:type|obo:NCIT_C174271 imgt:IgG1-kappa_505|rdf:type|imgt:MAbReceptor obo:NCIT_C26639|rdf:type|owl:Class imgt:Product_8a1dff90-0729-3d27-ae1d-58240f84e744|imgt:isProducedBy|imgt:AstraZeneca imgt:StudyProduct_217cb700-4aeb-3508-b4d2-0507125de6d5|imgt:application_type|Therapeutic imgt:Clone_472|obo:RO_0002162|imgt:Musmus imgt:nt-SEQUENCE|rdf:type|imgt:PrototypeLabel imgt:PROTEIN_1DOMAIN-PEG_1299|rdf:type|imgt:MAbReceptor pubmed:20848453|dc:contributor|Paradowski L imgt:IgG1-kappa_459|obo:RO_0002162|imgt:Chi _:B3d24548d0c2287c74b9a3697dbea474f|rdf:type|obo:NCIT_C53285 imgt:Clone_548|imgt:clone_name|mAb 62-7 imgt:StudyProduct_c89cbb23-8426-3d1a-923b-6d4614067671|imgt:development_technology| Medarex’s UltiMAb® imgt:UCB|imgt:produces|imgt:Product_5599efd0-7eee-32e0-ad93-253e80b8b7e3 imgt:mAb_316|imgt:hasOriginClone|imgt:Clone_316 imgt:IgG1-kappa-4F-drug_1265|imgt:isMabReceptorOf|imgt:mAb_1265 imgt:mAb_38|imgt:clinical_trials|54 studies found, 3 recruiting imgt:Severe_acute_respiratory_syndrome_coronavirus_2_(SARS-CoV-2)_infection_(COVID-19)|imgt:isClinicalIndicationOf|imgt:StudyProduct_aaf066df-3656-3025-80a3-0e31ed88ed73 _:B4691a4a555ffb6931d45fb9ddadea971|imgt:isDecisionOf|imgt:StudyProduct_53931e74-e525-3e5f-a76b-b4b9eef386f2 imgt:StudyProduct_32ef0399-42b0-3bc5-8e21-99bfc436083d|rdf:type|obo:NCIT_C174271 imgt:Product_788b3959-d5c8-36a5-9cf6-738181181b51|imgt:hasStudyProduct|imgt:StudyProduct_4a79c9a8-a58f-374e-8616-d854d046a585 imgt:Segment_638_1|rdf:type|imgt:Segment imgt:IgG1-kappa_832|imgt:isMabReceptorOf|imgt:mAb_832 imgt:StudyProduct_27c8d894-d57d-3373-ab92-3279a037a393|imgt:isStudyProductOf|imgt:Product_950458ce-5b79-3a87-87fd-0d76107f13a3 pubmed:8769601|dc:contributor|Everitt DE imgt:StudyProduct_e57f97a7-fa4f-39a9-9045-baf219cedaa6|rdf:type|obo:NCIT_C174271 _:Ba166c0b97e46582cfe441bceee6c3091|imgt:isDecisionOf|imgt:StudyProduct_3382d51d-375a-381d-b60d-bae05535edfa imgt:StudyProduct_53160b9b-908c-3b47-a3ba-007e3769a5b9|rdfs:label|StudyProduct_53160b9b-908c-3b47-a3ba-007e3769a5b9 imgt:mAb_1038|rdfs:label|mAb_1038 imgt:IgG1-lambda_1020|obo:RO_0002162|imgt:Homsap imgt:Solid_tumors_advanced_or_metastatic|imgt:isClinicalIndicationOf|imgt:StudyProduct_9cd1533d-275c-316f-9ca4-783d18d335e9 _:B9229d7530317b0720424efa4d0c2597d|rdf:type|obo:NCIT_C53285 imgt:IgG4-nd_3|obo:RO_0002162|imgt:Hum imgt:mAb_322|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=322 imgt:Immunocore_Ltd|rdf:type|obo:NCIT_C54131 imgt:8394|rdf:type|obo:NCIT_C25402 imgt:Segment_664_1|imgt:has_rank|1 imgt:Alzheimer's_disease_(AD)|imgt:isClinicalIndicationOf|imgt:StudyProduct_093b9da8-554b-37e8-b370-9f89231d1d46 imgt:mAb_306|imgt:hasProduct|imgt:Product_1d32d5b1-99c8-31ab-9a21-acfa4c132ab7 imgt:Solid_organ_transplantation|imgt:isClinicalIndicationOf|imgt:StudyProduct_b3707a7c-f821-3439-ad33-2ce9b53df2fa imgt:StudyProduct_894e7dce-e66b-3f46-8f3e-980db30eee88|imgt:hasClinicalPhase|imgt:Discontinued _:B41e6be87e7c0c8758554c9649489350c|imgt:isDecisionOf|imgt:StudyProduct_a6ee05b5-a108-3728-9f5b-572b4b75c954 imgt:StudyProduct_e9fde481-76d5-3f46-ac81-d553a0f4bfdc|imgt:hasDecision|_:Be0b8df7ead9c0c8ca291927c2b901e40 imgt:Segment_1294_2|imgt:hasImgtLabel|imgt:IGHG1 imgt:StudyProduct_523f91f2-d7a2-3adc-880c-37d5f48e29ee|rdf:type|obo:NCIT_C174271 obo:NCIT_C170056|rdf:type|owl:Class imgt:Product_92aaaa11-a012-35e5-91ee-9df570fa89a7|imgt:commun_name|TT-20 imgt:StudyProduct_3f3fa31d-ad6d-3aaf-9a33-8430698a356f|rdf:type|obo:NCIT_C174271 imgt:Product_a9814a14-a170-37d5-97fd-0fe8732330c2|imgt:comercial_name|ADBRY™ imgt:Segment_824_2|rdfs:label|Segment_824_2 imgt:IG-Heavy-Gamma-1-IGHG1|imgt:defines|imgt:F(ab’)2-Gamma-1_Kappa imgt:SCFV-HEAVY-LAMBDA|rdf:type|imgt:IGEngineeredLabel imgt:nt-sequence|imgt:hasMoleculeType|imgt:cDNA imgt:mAb_374|imgt:inn_name|vesencumab imgt:mAb_165|imgt:hasBiosimilar|imgt:exemptia™ imgt:StudyProduct_7df31001-106b-3fe6-bdaf-f3aa6220ebee|imgt:hasClinicalIndication|imgt:Sjögren's_syndrome_(SjS) imgt:mAb_549|rdf:type|obo:NCIT_C166561 imgt:mAb_48|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=48 imgt:mAb_1093|imgt:hasMabReceptor|imgt:IgG1-kappa_1093 imgt:mAb_1295|imgt:hasMabReceptor|imgt:PROTEIN_1DOMAIN-PEG_1295 imgt:Cancers|imgt:isClinicalIndicationOf|imgt:StudyProduct_e740b49f-ef40-3099-a862-172acdc49b48 imgt:StudyProduct_14857b94-bdbd-375d-bdb5-a38f05a59a47|rdf:type|obo:NCIT_C174271 obo:NCIT_C177082|rdfs:subClassOf|obo:NCIT_C1909 imgt:StudyProduct_76ee9841-a655-331c-a8ef-8ffe48ebe5fc|imgt:hasDecision|_:Bc314c5dfd0beab5555267e909a1e84a7 imgt:Product_2859659a-bdfb-39c3-b0b5-427c42e6772e|imgt:commun_name|XmAb-18087 imgt:mAb_73|imgt:hasProduct|imgt:Product_e457f880-631c-3188-aa6a-c8ab128920c4 imgt:Construct_219|imgt:isConstructOf|imgt:IgG2a-kappa-G2b-lambda_219 imgt:IgG1-kappa-4cys-drug_531|imgt:conjugated_with| monomethyl auristatin E (MMAE) imgt:INTEGRIN-ALPHA-V_BETA-3|rdfs:label|INTEGRIN-ALPHA-V_BETA-3 imgt:mAb_605|imgt:hasMabReceptor|imgt:IgG1-kappa_605 imgt:UTRLabel|rdfs:subClassOf|imgt:SequenceLabels imgt:Product_76eaaae8-3383-396f-85e7-82ee6811700f|imgt:hasStudyProduct|imgt:StudyProduct_633d71e4-8ac8-3c24-a663-f0e81ae95699 imgt:StudyProduct_dbb4efe4-fb5b-303b-a069-4274e46e9e76|imgt:development_technology| Medarex's HuMAb-Mouse® imgt:Construct_316|imgt:isConstructOf|imgt:Fab-G1-kappa_316 imgt:Product_46489dd5-dbbb-3ac3-a0f1-64d45c1d847d|imgt:hasStudyProduct|imgt:StudyProduct_2abedd27-0d04-310f-85eb-9cefebe62754 imgt:(scFv-heavy-lambda)-(scFv-heavy-lambda)-scFc|imgt:construction_detail|(scFv - heavy - lambda) - (scFv - heavy - lambda) - scFc imgt:Product_fde2e7c8-3ef2-3b15-af78-d71e7f78ed48|imgt:commun_name|OMP-336B11 imgt:IgG1-kappa-%5BscFv%5D2-lambda_1260|http://semanticscience.org/resource/SIO_000291|imgt:bispecific imgt:Product_c2f673d4-4d4a-3adb-886b-858a585b47df|rdf:type|obo:NCIT_C51980 imgt:StudyProduct_f50ee431-70f4-33e4-8ada-f65929afb9ef|imgt:isStudyProductOf|imgt:Product_6b5f5f16-7cf5-39b5-b310-37815f8f0675 imgt:Product_68b98f78-23f2-3109-8dac-c2bf17514d02|rdf:type|obo:NCIT_C51980 imgt:IgG2a-nd_159|imgt:radiolabelled_with| Iodine-131, I-131 imgt:Wellcome|imgt:produces|imgt:Product_cd47e1b0-c5b3-3b90-8d93-b3ae11351271 imgt:IgG1-kappa_292|obo:RO_0002162|imgt:Hum imgt:mAb_354|imgt:hasProduct|imgt:Product_31913cee-6bf1-33ef-9a45-4d5a8f0a7f07 imgt:StudyProduct_1a64ef25-30ed-3988-9d19-9bfcc5d21705|imgt:development_technology| POTELLIGENT® technology (afucosylation) imgt:IgG4-kappa_1013|http://semanticscience.org/resource/SIO_000291|imgt:BTLA imgt:StudyProduct_ef8f3262-0245-318d-8930-286f924c996e|rdfs:label|StudyProduct_ef8f3262-0245-318d-8930-286f924c996e imgt:IgG1-kappa_372|imgt:hasMolecularComponent|imgt:IG obo:GENO_0000894|rdf:type|owl:DatatypeProperty imgt:StudyProduct_54a408fb-797a-34fa-881f-f2ccc1170888|imgt:development_technology| Human antibody phage display library obo:NCIT_C152714|rdfs:subClassOf|obo:NCIT_C1909 _:Baef38c3255efc6a164d9f55101f6380e|imgt:hasDesignation|imgt:Orphan_drug imgt:StudyProduct_511551d8-5a7b-332f-9ab1-30391265e771|rdfs:label|StudyProduct_511551d8-5a7b-332f-9ab1-30391265e771 imgt:Construct_739|obo:BFO_0000051|imgt:Segment_739_1 imgt:Product_75213e5f-abd1-313f-9756-8a8ca92ac7a6|imgt:isProducedBy|imgt:MedImmune imgt:Construct_316|obo:BFO_0000051|imgt:Segment_316_1 imgt:StudyProduct_c344ff5c-cd56-36b9-95c9-d727c1fd324d|imgt:development_technology| BiTE® (Bispecific T cell Engager) technology _:B1227de591dc3b799ce2b98589e1b7754|imgt:isDecisionOf|imgt:StudyProduct_1476d57e-e613-3ba6-87ff-d89e430f5269 imgt:ganglioside_GD2_(disialoganglioside_GD2)|imgt:isTargetOf|imgt:IgM-nd_191 _:B6005b15c6cea0ef5b1dafd2c054c3af0|imgt:isDecisionOf|imgt:StudyProduct_0dce2b38-b5c1-3b34-9beb-fc4154b2b406 imgt:mAb_1|imgt:hasImgtStructureEntry|imgt:1QNZ imgt:mAb_1161|imgt:imgt_note| WHO Drug Information, Vol. 34, No. 3, 2020. Proposed INN List 124 – COVID-19 (special edition) (9 October 2020) pages 642-669. Proposed INN List 124 (19 December 2020, published on 22 January 2021) pages 929-1102. imgt:isInCluster|rdfs:range|imgt:Cluster imgt:IgG1-kappa_726|obo:RO_0002162|imgt:Chi imgt:Construct_899|imgt:isConstructOf|imgt:PROTEIN_1DOMAIN_899 imgt:Pulmonary_Fibrosis|imgt:isClinicalIndicationOf|imgt:StudyProduct_e06ffe39-2f35-3f04-be74-5419cd3e8cbb imgt:mAb_1080|imgt:inn_name|ociperlimab imgt:StudyProduct_3c33cf64-59ff-3621-8d4f-95a3d85afee6|imgt:isStudyProductOf|imgt:Product_f2202260-1eb1-3ea7-b7bb-a7ab1d7930ea imgt:urushiol|imgt:isTargetOf|imgt:IgM-nd_147 imgt:IgG1-kappa_1024|rdf:type|imgt:MAbReceptor imgt:Pacific_Meinuoke_Biopharmaceutical|rdfs:label|Pacific Meinuoke Biopharmaceutical imgt:Construct_532|rdf:type|imgt:Construct imgt:Product_d162eac6-223f-3784-93c7-8637ba2b95cc|imgt:commun_name|Herceptin obo:RO_0001018|rdfs:domain|faldo:Region imgt:StudyProduct_05d9da1b-2484-32a8-bb56-e744eba499d6|rdfs:label|StudyProduct_05d9da1b-2484-32a8-bb56-e744eba499d6 imgt:Construct_945|rdf:type|imgt:Construct imgt:StudyProduct_f1f705eb-d8fa-3012-b6f9-e7c7bd71e8af|rdfs:label|StudyProduct_f1f705eb-d8fa-3012-b6f9-e7c7bd71e8af imgt:Product_3fc6bf12-9b61-329f-b867-eef0c9cd3e83|imgt:comercial_name|AVONEX® imgt:Segment_1284_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:mAb_1182|imgt:inn_number|11730 imgt:Product_f9431fba-428e-323c-9e21-0749755e9867|imgt:hasStudyProduct|imgt:StudyProduct_a092c113-ef53-3347-91ad-e98ef6b5ee07 imgt:mAb_1142|imgt:inn_name|pucotenlimab imgt:mAb_1089|imgt:hasOriginClone|imgt:Clone_1089 imgt:mAb_1127|rdfs:label|mAb_1127 imgt:Product_4a3e77b0-665b-30cc-8259-ed42deba2921|imgt:hasStudyProduct|imgt:StudyProduct_0bed0fbb-df2b-3c03-97cf-ee0147aea3a7 imgt:StudyProduct_19d23e6a-0f31-3650-a817-d2389d919f74|rdf:type|obo:NCIT_C174271 imgt:IgG1-kappa_383|imgt:hasConstruct|imgt:Construct_383 imgt:VH-VH%27-CD8A_(CO-TM)-TNFRSF9_(CY)-CD247_1042|imgt:isMabReceptorOf|imgt:mAb_1042 imgt:IgG1-kappa_660|rdf:type|imgt:MAbReceptor imgt:StudyProduct_b640ca18-f817-3cac-8dfc-2577f5cf6533|imgt:hasClinicalIndication|imgt:Cancers imgt:Product_461df871-c57e-3675-a8b8-5adf43f433d2|imgt:hasStudyProduct|imgt:StudyProduct_44c485f5-acc3-3859-8ec2-393bf78f6765 imgt:Product_1c004b38-ab4d-3414-acd3-4ffa3acf8432|imgt:isProductOf|imgt:mAb_915 imgt:FAB-ALPHA-1_LAMBDA|rdf:type|imgt:IGProteolyticFragmentLabel _:B9cb6b421119a7a66c8dd9c6b40f49da6|dc:date|1998-11-02 imgt:GCG_(glucagon)_1-29|imgt:construction_detail|GCG (glucagon) 1-29 imgt:StudyProduct_7d369a83-a716-357a-9719-17a65fb7dd70|imgt:hasDecision|_:B8b82c2915c35e5edde2e383ae93f6248 imgt:mAb_795|rdf:type|imgt:INN imgt:mAb_119|rdfs:label|mAb_119 _:Bfb6b5f5f1e7561d7255233388ba98f3b|imgt:hasStatut|imgt:approval imgt:11039|imgt:isImgtStructureEntryOf|imgt:mAb_928 imgt:Product_86456ca7-4505-366e-b20b-f326034fb884|imgt:commun_name|XmAb-13676 imgt:StudyProduct_af7ab420-55ff-3688-8469-664dcd2fd595|imgt:isStudyProductOf|imgt:Product_e8e2ee19-1c69-36da-bcdc-799a693e4f34 imgt:mAb_813|imgt:hasProduct|imgt:Product_75cce571-6ed3-3584-a1b8-254106bc9344 imgt:Segment_223_1|rdfs:label|Segment_223_1 imgt:StudyProduct_98cfbff5-18f3-3691-9aae-50c4c87cc27f|imgt:hasDecision|_:B3f22013ecadccdd574074573031b98f3 imgt:IgG4-kappa_380|rdfs:comment|IgG4 - kappa imgt:mAb_485|imgt:inn_recommended_list|72 (2014) imgt:Construct_399|rdfs:label|Construct_399 imgt:FPIA_%5BPROTEIN%5D2-FC_1098|imgt:hasConstruct|imgt:Construct_1098 imgt:Prestige_Biopharma|rdfs:label|Prestige Biopharma imgt:StudyProduct_e8e9300b-a97f-321c-8ee3-f75077460019|imgt:hasClinicalIndication|imgt:Peripheral_T/NK_cell_lymphoma imgt:StudyProduct_7cdaa62c-f40b-376f-98e2-5a051c6cfebd|rdfs:label|StudyProduct_7cdaa62c-f40b-376f-98e2-5a051c6cfebd imgt:Clone_1199|imgt:isOriginCloneOf|imgt:mAb_1199 imgt:Clone_153|rdf:type|obo:NCIT_C37925 imgt:mAb_549|imgt:hasOriginClone|imgt:Clone_549 imgt:IFNAR2|rdfs:label|IFNAR2 imgt:StudyProduct_0377bba3-0de4-3daa-b4c6-b3ce69e88ebd|imgt:application_type|Therapeutic imgt:Segment_40_1|rdfs:label|Segment_40_1 _:B5b6a51774c412d0134e9fb2ede4123d2|dc:date|1992-12-01 obo:TXPO_0000039|rdfs:domain|obo:NCIT_C13303 imgt:StudyProduct_29562df2-37fe-38ae-a623-e694518eba7f|rdf:type|obo:NCIT_C174271 imgt:9983|imgt:isImgtStructureEntryOf|imgt:mAb_552 imgt:IgG1-kappa_151|imgt:hasMolecularComponent|imgt:IG pubmed:8097341|dc:contributor|Tolkoff-Rubin N imgt:TF_(transferrin)-aldifitox:diphteriatoxin_(AB_toxin)|imgt:construction_detail|Conjugate - TF (transferrin) - aldifitox : diphteriatoxin (AB toxin) imgt:Product_49c2056b-e4db-3d7e-aeaa-1e329f6571e9|imgt:commun_name|VEGF Trap imgt:StudyProduct_e70f8d7f-0b0e-3181-a268-f6a0bbead351|rdfs:label|StudyProduct_e70f8d7f-0b0e-3181-a268-f6a0bbead351 imgt:Construct_533|imgt:isConstructOf|imgt:IgG4-kappa_533 imgt:5'D-RS|rdf:type|imgt:RSLabel pubmed:11567989|dc:contributor|Burt R imgt:StudyProduct_3b57dabc-8b1c-3bd7-8860-69b9a49dacff|imgt:hasClinicalIndication|imgt:Type_2_diabetes_(T2_DM) imgt:StudyProduct_ebcb3db3-7b55-3b5e-8422-c77a52525bed|imgt:application_type|Therapeutic imgt:mAb_623|imgt:inn_name|interferon alfacon-1 imgt:F(ab)2_Fab/Fab2_mix|rdf:type|imgt:SegmentLabels imgt:Lymphoma_follicular_(FL)|imgt:isClinicalIndicationOf|imgt:StudyProduct_47845097-3a00-3b73-9d59-751c4db6a7ee imgt:mAb_122|imgt:clinical_trials|106 studies found, 2 recruiting imgt:Segment_399_2|obo:BFO_0000050|imgt:Construct_399 imgt:StudyProduct_c7cbe6b9-42a8-3392-9a26-30418a5ea2fc|imgt:hasClinicalIndication|imgt:Cancers_non-small_cell_lung_(NSCLC) imgt:8750|rdf:type|obo:NCIT_C25402 imgt:StudyProduct_817d7dd9-adc5-3ddc-9be8-14ed17a6efa3|imgt:application_type|Therapeutic imgt:8659|rdfs:label|8659 imgt:Gilead|imgt:produces|imgt:Product_27c6ab4e-8ce9-3ad2-92b3-945ee20d9e46 imgt:Segment_188_1|imgt:hasImgtLabel|imgt:Fab-G4-nd imgt:Product_27c6ab4e-8ce9-3ad2-92b3-945ee20d9e46|imgt:hasStudyProduct|imgt:StudyProduct_43b4a6eb-8e7d-3a22-b455-e3bc4f0fe16f imgt:StudyProduct_fd194c74-f540-38f0-872a-903748af28de|imgt:hasClinicalIndication|imgt:Muscle_atrophy_due_to_orthopedic_disuse imgt:Product_8e98d81f-8217-3049-b5cc-b23337bb5761|imgt:commun_name|BAYX1351 imgt:StudyProduct_d95d6c77-5a9d-310e-ae65-ca3ae3a37094|imgt:hasClinicalPhase|imgt:Phase_III imgt:StudyProduct_15335a0b-21d4-30ab-baca-3f098f84411e|rdfs:label|StudyProduct_15335a0b-21d4-30ab-baca-3f098f84411e imgt:Segment_1247_1|rdfs:label|Segment_1247_1 imgt:StudyProduct_394d4b82-fd16-3fbe-809d-af59b6380eb1|imgt:hasDecision|_:Bd4171fde044b99367a9cf33cca5762f3 imgt:V-D-gene|imgt:hasConfigurationType|imgt:PR imgt:mAb_426|rdf:type|imgt:INN imgt:Construct_718|rdf:type|imgt:Construct imgt:Product_c5f39918-e8ab-30c6-887b-1fb87d6ca127|imgt:commun_name|CC-99712 imgt:IgG1-kappa_766|imgt:isMabReceptorOf|imgt:mAb_766 imgt:StudyProduct_64e82bf7-3479-3db0-b7ab-3c08257b473f|imgt:hasClinicalPhase|imgt:Phase_I/II imgt:Construct_396|imgt:isConstructOf|imgt:CARRIER_BIG-PROTEIN_1DOMAIN_396 imgt:IgG1-kappa_1140|imgt:hasMolecularComponent|imgt:IG imgt:IgG2-lambda_944|obo:RO_0002162|imgt:Homsap imgt:Product_8444096c-f72a-39f9-a0e2-cc5f210e9b8d|imgt:isProducedBy|imgt:Medarex imgt:IgG1-kappa_845|imgt:isMabReceptorOf|imgt:mAb_845 imgt:StudyProduct_7d240539-92d2-38a0-9db1-90963f0f98d8|imgt:hasClinicalIndication|imgt:Pemphigus_vulgaris_(PV) imgt:Clone_1055|imgt:isOriginCloneOf|imgt:mAb_1055 imgt:Product_031662a0-3a4d-355b-86b2-68009454e886|imgt:commun_name|BGB-A317 imgt:Fab-Gamma-2-c_Lambda|rdfs:label|Fab-Gamma-2-c_Lambda imgt:mAb_1180|rdf:type|obo:NCIT_C184859 imgt:StudyProduct_f8928c21-029a-311e-a5ae-b2505b18b929|rdf:type|obo:NCIT_C174271 _:B16b4025d7ff1771961c42d80456c77ec|imgt:isDecisionOf|imgt:StudyProduct_d434aff9-6703-3bb9-bf7d-2b8c4392570a imgt:IgG1-kappa_1279|rdf:type|imgt:MAbReceptor imgt:Segment_369_1|obo:BFO_0000050|imgt:Construct_369 imgt:StudyProduct_67d2606d-300b-30ce-81c9-51ffbe43758e|imgt:hasClinicalPhase|imgt:Phase_I imgt:StudyProduct_99437481-72fe-3999-af98-dd27259f1f62|imgt:hasClinicalPhase|imgt:Phase_III imgt:Construct_172|obo:BFO_0000051|imgt:Segment_172_1 imgt:TR-Beta-2-TRBC2|imgt:defines|imgt:TR-Alpha_Beta-2 imgt:IgG1-kappa_560|rdfs:comment|IgG1 - kappa imgt:VH-Vkappa-h-CH3_1246|imgt:hasConstruct|imgt:Construct_1246 imgt:AbbVie_Inc|rdf:type|obo:NCIT_C54131 imgt:mAb_807|imgt:inn_proposed_list|118 (2017) imgt:mAb_951|rdf:type|imgt:INN imgt:Clone_1141|rdf:type|obo:NCIT_C37925 imgt:mAb_180|imgt:atc_link|http://www.whocc.no/atc_ddd_index/?code=L01XC11 obo:NCIT_C166670|rdfs:subClassOf|obo:NCIT_C1909 imgt:Segment_1269_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Product_4b923003-44a0-305e-869a-41e26bddedbb|imgt:hasStudyProduct|imgt:StudyProduct_3f06c08f-d26e-30b2-9344-72cf4676c965 imgt:StudyProduct_296f279e-8084-328b-b38c-9b44cf4d7e5b|imgt:isStudyProductOf|imgt:Product_950458ce-5b79-3a87-87fd-0d76107f13a3 imgt:Segment_368_1|imgt:has_rank|1 imgt:IG-Heavy-Zeta|rdf:type|imgt:ClassLevelChainType imgt:StudyProduct_4ceeafbd-cd1c-3ed8-9980-a390e57b69f6|imgt:hasClinicalIndication|imgt:Cancers_lung _:B7757c1d13ee22715094e8b2c83325081|imgt:isDecisionOf|imgt:StudyProduct_7c7d1559-1e96-3c5e-9e42-3aac703c1921 imgt:StudyProduct_4ceeafbd-cd1c-3ed8-9980-a390e57b69f6|imgt:development_technology| Cambridge Antibody Technology (CAT) human antibody phage display library imgt:9549|imgt:isImgtStructureEntryOf|imgt:mAb_407 imgt:mAb_631|imgt:hasBiosimilar|imgt:nivestym imgt:Construct_532|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:3SBio_Inc|rdf:type|obo:NCIT_C54131 imgt:Kidney_transplant_rejection|imgt:isClinicalIndicationOf|imgt:StudyProduct_c0feab04-ef70-3102-ad3e-c6f59586ef54 imgt:Chronic_lymphocytic_leukemia_(CLL)|imgt:clinical_domain|Hematology imgt:FAB-GAMMA-4_LAMBDA|rdf:type|imgt:IGProteolyticFragmentLabel imgt:StudyProduct_e4753962-2042-3ac1-845c-e6d1c1f142cd|rdf:type|obo:NCIT_C174271 imgt:IgG_Kappa|imgt:isDefinedBy|imgt:IG-Light-Kappa-IGKC imgt:mAb_1088|imgt:inn_proposed_list|123 (2020) imgt:IgG4-kappa_1121|rdfs:comment|IgG4 - kappa imgt:Product_2155a726-3d06-3867-beba-3c3ffc3763ac|imgt:isProducedBy|imgt:AbGenomics_International_Inc imgt:Construct_452|rdf:type|imgt:Construct imgt:11617|imgt:isImgtStructureEntryOf|imgt:mAb_1127 imgt:10675|imgt:isImgtStructureEntryOf|imgt:mAb_768 imgt:Construct_1253|imgt:isConstructOf|imgt:VH-VH%27_1253 imgt:mAb_561|imgt:inn_proposed_list|113 (2015) imgt:Product_485d748c-9ee2-352a-aaf4-3297a649c274|imgt:commun_name|MEDI-563 imgt:VEGFA|imgt:isTargetOf|imgt:VH-VH%27-H-Gamma1-VL-VL%27-C-kappa_847 imgt:IgG4-kappa_402|obo:RO_0002162|imgt:Homsap imgt:V-LAMBDA-CH1_VH-C-KAPPA|rdfs:label|V-LAMBDA-CH1_VH-C-KAPPA imgt:mAb_1244|imgt:hasMabReceptor|imgt:IgG2-kappa_2bridges_1244 pubmed:9099717|dc:contributor|O Connor SJ imgt:Product_43b270ab-cd45-3fb5-8ca6-df0952c4ef21|imgt:isProducedBy|imgt:Viela_Bio_Inc imgt:mAb_1150|imgt:inn_proposed_list|124 (2020) imgt:mAb_246|imgt:inn_number|8963 imgt:11136|rdfs:label|11136 imgt:VH-CH1-VH-C-KAPPA-CH2-CH3_V-LAMBDA-CH1_GAMMA-1_KAPPA|skos:definition|IG receptor comprising one VH-CH1-VH-C-KAPPA-CH2-CH3, one V-LAMBDA-CH1, one GAMMA-1 and one KAPPA chains imgt:Construct_84|imgt:hasImgtLabel|imgt:Fab-G1-kappa imgt:F(ab)2_Fab/Fab2_mix|rdfs:label|F(ab')2, Fab / Fab2 mix imgt:mAb_225|imgt:inn_proposed_list|100 (2008) imgt:StudyProduct_be0fbf31-1f72-3e6f-815f-9afad32e31d4|imgt:isStudyProductOf|imgt:Product_3324747e-377b-32d2-95cf-77fa2a26537b imgt:LILRB1|rdfs:label|LILRB1 imgt:PEPTIDE-B2M-I-ALPHA|rdf:type|imgt:MHEngineeredLabel imgt:mAb_306|imgt:hasMabReceptor|imgt:Fab%27-G2a-kappa_306 imgt:Construct_1010|rdf:type|imgt:Construct imgt:remsima™|imgt:isBiosimilarOf|imgt:mAb_156 imgt:StudyProduct_ede10d1b-4226-3599-97e7-be03d65b31c6|imgt:hasClinicalIndication|imgt:Cancers_bladder imgt:Product_70626d7d-afcd-3d0c-944a-b65990e20e32|imgt:isProducedBy|imgt:Human_Genome_Sciences_Inc_(HGSI) imgt:9711|imgt:isImgtStructureEntryOf|imgt:mAb_456 imgt:Segment_584_1|obo:BFO_0000050|imgt:Construct_584 imgt:Product_4e1880fa-d60f-380e-b923-b4655d254d89|rdf:type|obo:NCIT_C51980 imgt:Product_8d42cf3e-0201-36e0-9ec3-281e3d9c1f54|imgt:isProducedBy|imgt:Unilever imgt:mAb_172|imgt:hasProduct|imgt:Product_92aaaa11-a012-35e5-91ee-9df570fa89a7 imgt:Segment_690_1|imgt:has_rank|1 imgt:IgG4-kappa_1021|rdfs:comment|IgG4 - kappa imgt:mAb_302|imgt:inn_name|rilotumumab imgt:mAb_207|imgt:inn_recommended_list|32 (1992) _:B6a407e496338df091af9dc7952bf9587|imgt:isDecisionOf|imgt:StudyProduct_04a588ca-f4e9-3453-8e00-e517064379bc imgt:mAb_1200|imgt:inn_name|vepsitamab imgt:StudyProduct_5e68f673-771d-3e00-9436-90e16636d1fc|imgt:application_type|Therapeutic imgt:Segment_1247_1|imgt:hasImgtLabel|imgt:IgG1-lambda2 imgt:Construct_962|obo:BFO_0000051|imgt:Segment_962_1 imgt:10014|imgt:isImgtStructureEntryOf|imgt:mAb_530 _:B435cd12d5876b3a331e1c46d93abeaa1|imgt:isDecisionOf|imgt:StudyProduct_8c63dc3d-4414-3596-928d-549fc6f3f5b1 imgt:mAb_1275|rdf:type|obo:NCIT_C1909 imgt:Clone_1241|obo:RO_0002162|imgt:Musmus imgt:10242|imgt:isImgtStructureEntryOf|imgt:mAb_604 imgt:StudyProduct_e20403bd-7c3c-33eb-84b6-74e03b01492a|imgt:hasClinicalIndication|imgt:Rheumatoid_arthritis_(RA) imgt:StudyProduct_e3b079bc-4e67-356b-800d-4abbf31ae8da|rdfs:label|StudyProduct_e3b079bc-4e67-356b-800d-4abbf31ae8da imgt:StudyProduct_657ccc33-24fa-3743-a75a-6111c145c586|imgt:application_type|Therapeutic imgt:bispecific|imgt:isTargetOf|imgt:IgG4-nd_304 imgt:Clone_1285|imgt:clone_name|CLI-97445 _:Bd9f52fce09c403f141619631fc6a8dec|imgt:isDecidedBy|imgt:FDA imgt:Construct_1158|rdfs:label|Construct_1158 imgt:mAb_851|imgt:inn_recommended_list|81 (2019) imgt:StudyProduct_08184582-b131-3764-92a2-abfde04a4586|imgt:application_type|Therapeutic imgt:mAb_1276|imgt:inn_number|11920 imgt:CD37|imgt:isTargetOf|imgt:IgG1-kappa_603 imgt:Construct_652|rdfs:label|Construct_652 imgt:StudyProduct_f175da2f-c4f7-36e5-98a4-83da5714dd72|imgt:hasClinicalIndication|imgt:Cancers imgt:StudyProduct_06260074-2b09-3e09-985e-750d29aa369c|imgt:application_type|Therapeutic imgt:StudyProduct_a1504ba6-644f-3bb1-b6d8-21de11e72fd2|imgt:application_type|Therapeutic _:Bb43205bb67745f7bb180c22c9a89d373|imgt:isDecisionOf|imgt:StudyProduct_4cdd49cd-0f02-370e-95fe-8121a698d4fe imgt:Segment_1293_1|imgt:hasImgtLabel|imgt:SIRPA imgt:StudyProduct_075258bb-8978-32df-ba1a-e24b9cbe38f8|rdf:type|obo:NCIT_C174271 imgt:IgG1-kappa_479|obo:RO_0002162|imgt:Homsap _:B6940295421591c166e47db2cef5c9b59|imgt:isDecisionOf|imgt:StudyProduct_205fae1d-bebf-35b0-8d3f-36902092b1c1 imgt:StudyProduct_fb834bc6-a761-32b7-ac2b-49f6c3d77751|rdfs:label|StudyProduct_fb834bc6-a761-32b7-ac2b-49f6c3d77751 imgt:StudyProduct_265e0198-3ea2-3531-8868-6e4397870ed7|imgt:isStudyProductOf|imgt:Product_7b6e3c54-31d7-3948-b87d-dec2c46600ca imgt:StudyProduct_6a8a9e2e-2b56-336b-b146-1e73cbaccb25|rdf:type|obo:NCIT_C174271 imgt:Segment_452_1|imgt:has_rank|1 imgt:10248|imgt:isImgtStructureEntryOf|imgt:mAb_606 imgt:FUSION-FLT1-KDR-KDR-GAMMA-1|skos:definition|FLT1, KDR fused with G1 H-CH2-CH3 imgt:Clone_317|rdfs:label|Clone_317 imgt:Leucocyte_immunoglobulin-like_receptor|skos:altLabel|LILR _:B521db1daf2dfea1b309fd1ba5028e648|dc:date|2009-10-26 imgt:Segment_118_1|imgt:hasImgtLabel|imgt:IgM-nd imgt:Cancers_non-small_cell_lung_(NSCLC)|imgt:isClinicalIndicationOf|imgt:StudyProduct_ea24d68c-bf95-39b6-9bf8-7e8b20c753ee imgt:mAb_755|imgt:inn_proposed_list|117 (2017) imgt:Clone_583|rdfs:label|Clone_583 imgt:8627|rdf:type|obo:NCIT_C25402 imgt:Ganymed_Pharmaceuticals_AG|rdf:type|obo:NCIT_C54131 imgt:mAb_531|imgt:hasProduct|imgt:Product_15a67350-7e03-3a46-9478-b8533a0c6d6a _:Bee95eff4bc9ae9efa2223b9e7873c257|imgt:isDecidedBy|imgt:FDA imgt:Product_07a0f8df-d456-3179-a3a2-ab802e7d3e13|imgt:isProducedBy|imgt:Elan_Pharmaceuticals_International_Ltd imgt:10962|imgt:isImgtStructureEntryOf|imgt:mAb_905 imgt:FUSION-F10-GAMMA1|skos:definition|F10 fused with G1 H-CH2-CH3 imgt:StudyProduct_b35fef56-9616-3739-b99e-e60d25ac99ff|imgt:hasDecision|_:Ba60abafd1f665d338144a111e02064a9 imgt:StudyProduct_a09699b6-3df5-36aa-8724-b398d8742a93|imgt:application_type|Therapeutic imgt:V-D-GENE|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/IMGTScientificChart/SequenceDescription/Prototypes/V-D-gene.png imgt:Product_2cc853dd-e3c6-3e19-a19e-85aa74315a15|rdf:type|obo:NCIT_C51980 imgt:Product_a906e8c2-5cd0-31d0-9f46-849a19d4b85b|imgt:commun_name|IPH-2201 imgt:G1-kappa_scFv-h-CH2-CH3_1085|imgt:hasMolecularComponent|imgt:IG imgt:Segment_395_2|rdf:type|imgt:Segment imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_55d51286-cae4-33a9-8b0a-0a0b363bf154 imgt:Malignant_melanoma|imgt:clinical_domain|Oncology imgt:StudyProduct_c75294a2-ea9c-39c5-945a-77fcbfc9098c|imgt:isStudyProductOf|imgt:Product_cc1f4c5e-16f9-3c1a-81a2-ad837c23f5bb imgt:IgG1-kappa_1205|rdf:type|imgt:MAbReceptor imgt:Theratechnologies_Inc|rdf:type|obo:NCIT_C54131 imgt:Product_e29f95d1-36be-37c4-9018-e60cabbdb8fb|rdfs:label|Product_e29f95d1-36be-37c4-9018-e60cabbdb8fb imgt:Construct_570|rdf:type|imgt:Construct _:B0c4fd5beX2D3e5aX2D4dc8X2D8f27X2D2d00f6e3cbe6|rdf:rest|_:B24912af8X2D1efeX2D4f17X2Db82bX2D91c14b8d6590 imgt:StudyProduct_659bf455-776a-356c-a03d-c231f4a90bfb|imgt:hasClinicalPhase|imgt:Phase_M imgt:mAb_1012|rdf:type|imgt:INN imgt:Myelodysplastic_syndromes_(MDS)|imgt:isClinicalIndicationOf|imgt:StudyProduct_c93d5477-8120-313a-86b7-5b1befbe0ef3 imgt:Segment_929_1|obo:BFO_0000050|imgt:Construct_929 imgt:IgG1-lambda_792|rdf:type|imgt:MAbReceptor imgt:StudyProduct_8a7cffa2-ee9b-30b9-a732-f2a8a18eaccd|rdfs:label|StudyProduct_8a7cffa2-ee9b-30b9-a732-f2a8a18eaccd imgt:StudyProduct_0edfb1a4-09c1-3456-ad47-0195bbf930db|imgt:hasDecision|_:Bbaa7c693ecd00ec56c00893dba22c7ae imgt:Product_a0661df8-0511-3add-a6da-197740d48a46|imgt:hasStudyProduct|imgt:StudyProduct_53bc7d93-ee19-3044-a1b4-9aff91b5dc3d imgt:Product_f1c66e81-e055-3249-bd68-d8e92af8b5d6|imgt:isProductOf|imgt:mAb_950 imgt:mAb_713|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=713 imgt:Product_676ba184-966c-385e-a940-72fcf5428927|imgt:hasStudyProduct|imgt:StudyProduct_08400b71-c331-322e-84e6-bea111d08e0e imgt:StudyProduct_0e54bccd-7463-3c62-b3aa-f7ef86c2fb45|imgt:hasClinicalIndication|imgt:Crohn's_disease_(CD) imgt:StudyProduct_b773e9af-4dab-3a2b-bbe9-84818f1cb689|imgt:hasClinicalPhase|imgt:Phase_I imgt:mAb_526|imgt:hasImgtStructureEntry|imgt:9814 imgt:Life_Science_Pharmaceuticals_(LSP)|rdfs:comment|Darien , USA imgt:StudyProduct_d056838d-1c33-3a44-80ed-6217d85daf28|imgt:hasClinicalIndication|imgt:Graft-versus-host_disease_(GvHD) _:B4e270ba9ad4b757bb11ac2e4ec5a7c47|dc:date|2017-02-15 imgt:mAb_134|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=134 imgt:Clone_493|rdfs:label|Clone_493 imgt:StudyProduct_dc3d33f4-c22a-3435-b95f-e883651517dc|imgt:application_type|Therapeutic imgt:IgG1-kappa_677|obo:RO_0002162|imgt:Homsap imgt:StudyProduct_3dd848dc-265a-30d8-ba58-470497ee2ecb|imgt:application_type|Therapeutic imgt:IG-Heavy-Gamma-2-IGHG2|imgt:defines|imgt:Fab-Gamma-2_Lambda imgt:CD33|obo:RO_0002162|imgt:Homsap imgt:UTRLabel|rdf:type|owl:Class imgt:CPCA_PEPTIDE-PEG-FC_673|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/CPCA_PEPTIDE-PEG-FC.png imgt:Segment_412_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Clone_1258|imgt:clone_name|CS9-8765-50C-016 imgt:Cytomegalovirus_(CMV)_retinitis_in_HIV_individuals|rdfs:label|Cytomegalovirus_(CMV)_retinitis_in_HIV_individuals imgt:Immunomedics_Inc|imgt:produces|imgt:Product_ed8d0555-7f62-3cdb-9892-679238204c82 imgt:Segment_1156_2|imgt:hasImgtLabel|imgt:FGF21 imgt:StudyProduct_d84bded9-4720-3ab6-acaf-6d8202bfa9d7|rdfs:label|StudyProduct_d84bded9-4720-3ab6-acaf-6d8202bfa9d7 imgt:GlaxoSmithKline|rdfs:label|GlaxoSmithKline obo:NCIT_C186389|rdfs:subClassOf|obo:NCIT_C1909 imgt:Segment_900_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:StudyProduct_06260074-2b09-3e09-985e-750d29aa369c|imgt:isStudyProductOf|imgt:Product_499c41a6-6810-367e-b82d-0cab484bef45 imgt:Product_b7880def-b276-350c-b17c-1e311165b834|imgt:isProducedBy|imgt:TolerRx imgt:Product_22ec6ed9-ddd5-3fc9-bb08-2d8f3efa3145|rdf:type|obo:NCIT_C51980 imgt:Segment_693_1|rdfs:label|Segment_693_1 imgt:mAb_874|rdf:type|imgt:INN pubmed:16796401|dc:contributor|Bogaards J.A. imgt:StudyProduct_2ecb4a3d-036e-38d3-90fd-b81e950654d9|imgt:hasClinicalPhase|imgt:Phase_I imgt:Product_2b62ff3b-5777-30b1-8021-af790e255f4e|imgt:commun_name|MSTT-1041A imgt:StudyProduct_deb0d4c3-e3f4-3460-89c0-e57d8a8012bf|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:Product_6a75c3c7-fd9d-3d13-ba55-34265317c29e|rdf:type|obo:NCIT_C51980 imgt:StudyProduct_a2cf14ef-242a-32b4-817c-814f3fcb2e78|imgt:isStudyProductOf|imgt:Product_fd0b72db-60e6-31cc-a245-99cd2c771b5c imgt:Adrenomed_AG|rdfs:comment|Berlin , Germany imgt:D-SEQUENCE|imgt:describes|imgt:D-sequence pubmed:3025856|rdf:type|bibo:Article imgt:StudyProduct_0496c16f-ccc1-3a11-bab5-7c11d4a7c9d8|imgt:isStudyProductOf|imgt:Product_0c5fb596-41fb-3ab4-bbc2-3ab6a19b5b7e imgt:StudyProduct_993b42c9-04b6-37fc-aee8-478969b79fa4|imgt:hasClinicalPhase|imgt:Phase_I imgt:Clone_785|imgt:clone_name|CHO-hMAdCAM imgt:StudyProduct_a78a0ef6-c705-3475-860d-516b5d771dea|imgt:application_type|Therapeutic imgt:9937|imgt:isImgtStructureEntryOf|imgt:mAb_498 imgt:TR-ALPHA_BETA-1|imgt:describes|imgt:TR-Alpha_Beta-1 imgt:Product_4a4c4d40-304a-3d8a-bef8-533a579b445d|imgt:commun_name|CP-675 imgt:11178|rdfs:label|11178 imgt:IgG4-nd_256|rdfs:comment|IgG4 - nd imgt:StudyProduct_30da3412-82dc-3f86-88c1-ec96530ef15e|rdf:type|obo:NCIT_C174271 imgt:IgG2-kappa_332|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG2-kappa.png imgt:mAb_384|imgt:clinical_trials|16 studies found, 1 recruiting imgt:StudyProduct_c780fd60-6ed4-3fa5-98ff-6f99ea05fa73|imgt:hasClinicalPhase|imgt:Phase_II imgt:Construct_700|obo:BFO_0000051|imgt:Segment_700_1 imgt:Product_e2143545-5d26-34de-b5c8-ca4bd86a34ed|imgt:commun_name|RO4905417 imgt:StudyProduct_baa41ac1-2853-3eba-ae43-e487b5c0b4c0|imgt:hasClinicalPhase|imgt:Phase_III imgt:Construct_1185|rdf:type|imgt:Construct imgt:StudyProduct_2f224868-e1d3-3d64-af06-4fe62117359e|imgt:development_technology| Chimeric antigen receptor (CAR) T cell engineering obo:NCIT_C66250|rdfs:subClassOf|obo:NCIT_C1909 imgt:Product_2ac5f9dd-3aa5-3b90-9b7c-53e60c91c010|rdf:type|obo:NCIT_C51980 imgt:IgG1-kappa_464|rdfs:comment|IgG1 - kappa imgt:10071|imgt:isImgtStructureEntryOf|imgt:mAb_540 imgt:mAb_490|imgt:inn_name|coltuximab ravtansine imgt:StudyProduct_a4b72b6a-53ce-3ee3-83c5-d44557866ec1|imgt:hasDecision|_:B5a45b170f0ed0a178bf18d3af3ffa4c9 imgt:StudyProduct_0495e57b-cb2a-3257-97f1-514265b7029e|imgt:isStudyProductOf|imgt:Product_14f620fd-0f5f-3fcf-9e8d-6e6e07d90e2f imgt:8829|rdfs:label|8829 imgt:PTCRA|skos:definition|Chain comprising a PTCRA domain imgt:isImgtStructureEntryOf|rdfs:domain|obo:NCIT_C25402 imgt:CD19|imgt:isTargetOf|imgt:IgG1-kappa_522 imgt:Memorial_Sloan-Kettering_Cancer_Center|imgt:produces|imgt:Product_64e1bff1-0f5a-303d-b828-f9d0ba753344 pubmed:3025856|dc:contributor|Chang N. imgt:HIV-1_infection_AIDS|imgt:isClinicalIndicationOf|imgt:StudyProduct_b2b249c3-cc16-3340-bddf-90eda84c6f06 imgt:SCFV-HEAVY-KAPPA-JCHAIN-ALB|rdf:type|imgt:ChainLabels imgt:mAb_355|imgt:hasMabReceptor|imgt:IgG1-kappa_355 imgt:StudyProduct_287051db-080e-3600-9859-ab870372958f|rdfs:label|StudyProduct_287051db-080e-3600-9859-ab870372958f imgt:F(ab’)2-Gamma-2-c_Lambda|imgt:isDefinedBy|imgt:IG-Heavy-Gamma-2-c-IGHG2C imgt:10830|imgt:isImgtStructureEntryOf|imgt:mAb_862 imgt:StudyProduct_fde46a8f-ed1b-33b3-87d9-2d2beba40527|rdfs:label|StudyProduct_fde46a8f-ed1b-33b3-87d9-2d2beba40527 imgt:IgG1-nd_MM_305|rdf:type|imgt:MAbReceptor imgt:StudyProduct_20e8e725-943b-3b5e-8b74-61b52cd48797|rdf:type|obo:NCIT_C174271 imgt:GCGR|imgt:isTargetOf|imgt:PEPTIDE_693 imgt:StudyProduct_5893f77a-8ead-33d5-accb-55e4c2563b5d|rdfs:label|StudyProduct_5893f77a-8ead-33d5-accb-55e4c2563b5d imgt:IFNB1_(interferon_beta_1_IFNB)_*b_(S38)_22-187|rdf:type|imgt:ConstructLabels imgt:Segment_1086_1|rdf:type|imgt:Segment imgt:CXCR4|rdf:type|imgt:ChainLabels imgt:IntegrinDomainLabel|rdfs:label|IntegrinDomainLabel imgt:StudyProduct_8037ac88-b353-3582-afaf-b797db588a1b|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_d33d64b5-0bc8-3616-8a84-7afbb5771141|imgt:isStudyProductOf|imgt:Product_bf5d4fd3-0df7-3e8b-b83a-7f0e170fc5f1 imgt:Segment_405_1|obo:BFO_0000050|imgt:Construct_405 imgt:IL33|rdfs:label|IL33 imgt:Segment_1292_2|obo:BFO_0000050|imgt:Construct_1292 imgt:StudyProduct_c9cc9b8f-768e-34d7-8f47-1cb65379c659|imgt:hasExpressionSystem|imgt:_NS0_mouse_myeloma_cells imgt:Construct_1231|rdfs:label|Construct_1231 imgt:IgG1-kappa_MM_663|imgt:hasConstruct|imgt:Construct_663 imgt:IgG1-kappa_1268|rdfs:label|IgG1-kappa_1268 imgt:IgG1-kappa_416|rdf:type|imgt:MAbReceptor imgt:Segment_139_1|rdfs:label|Segment_139_1 _:Bbe7ec607f67369536d676242fd86b879|imgt:isDecisionOf|imgt:StudyProduct_6b612b11-5933-3c77-871a-d835dd207209 imgt:StudyProduct_92f2fb2e-8900-3e85-8ee1-e2bd4eb88525|imgt:hasClinicalIndication|imgt:Solid_tumors _:B1b1c371064d6c3665bb31e9a96dccaea|imgt:isDecidedBy|imgt:FDA imgt:11877|imgt:isImgtStructureEntryOf|imgt:mAb_1208 imgt:C4B|skos:definition|C4B (CPAMD3, C4F, CO4, C4B1, C4B3) imgt:StudyProduct_a414af3e-eea8-303a-966b-5051ae5bf14b|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_ad128f55-9f9a-39d6-8b42-149263c92261|rdf:type|obo:NCIT_C174271 imgt:Segment_1092_1|imgt:has_rank|1 imgt:mAb_363|rdf:type|obo:NCIT_C84838 imgt:StudyProduct_cb7167ad-d7e4-3970-8752-f2a0b6b7e5e5|imgt:hasDecision|_:B173597b6c55377007625b35cf541b99d imgt:IgG1-kappa_1070|obo:RO_0002162|imgt:Hum imgt:IgG1-kappa_1040|imgt:isMabReceptorOf|imgt:mAb_1040 imgt:StudyProduct_1203e490-9d6a-3d75-be80-4d3b7b3081d3|imgt:isStudyProductOf|imgt:Product_80543f95-22b7-3761-a574-ef4df0802d70 imgt:StudyProduct_a3efdb33-e7a0-3712-96a4-1d95f7771e48|rdfs:label|StudyProduct_a3efdb33-e7a0-3712-96a4-1d95f7771e48 imgt:PROTEIN_1DOMAIN-PEG_630|imgt:hasMolecularComponent|imgt:RPI imgt:Clone_799|imgt:clone_name|NVS240705 imgt:Construct_712|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:_NS0_mouse_myeloma_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_fc5cc4ff-cd79-3360-ba2c-9cb8a2518a23 imgt:INSR|imgt:isTargetOf|imgt:PROTEIN_1DOMAIN_707 imgt:StudyProduct_806e3c6b-f05c-36ea-9c25-129a9939f774|imgt:application_type|Therapeutic imgt:G-ALPHA2|rdf:type|imgt:RegionLabel _:Bb237fc160ebc2ebce1248c9e54641f29|imgt:isDecidedBy|imgt:EMA imgt:Product_c9b09440-3c97-37f9-a7a3-a051cfd3499c|imgt:hasStudyProduct|imgt:StudyProduct_c835e86f-15ee-3de6-a65b-fb6d7d0c48c9 imgt:Product_c9f2fb89-0971-33be-b453-f94d57bafe91|imgt:commun_name|AT13/5 _:B125fc06bX2D4b3fX2D4981X2Dac8bX2D527509778ea1|rdf:first|imgt:fusion_protein_for_immune_applications imgt:hasProduct|rdf:type|owl:ObjectProperty _:B53c7267f9fb06eec9de78d901eb9ca98|dc:date|2018-01-30 imgt:isBibliographicReferenceOf|owl:inverseOf|imgt:hasBibliographicReference imgt:Fab-G1-kappa|rdfs:label|Fab - G1 - kappa imgt:mAb_1003|imgt:inn_proposed_list|122 (2019) imgt:mAb_1190|imgt:hasProduct|imgt:Product_9fe2aea9-6590-3730-92bb-c9b32d85d073 imgt:mAb_572|rdf:type|obo:NCIT_C116629 imgt:IgG1-nd_55|imgt:isMabReceptorOf|imgt:mAb_55 imgt:Chugai_Pharmaceutical_Co_Ltd|imgt:produces|imgt:Product_589c62e2-46ec-3016-ac0f-8ee0131ebfaf imgt:mAb_225|imgt:inn_name|racotumomab imgt:StudyProduct_94fd6c18-f98f-3ee1-acea-07361913e4d2|imgt:hasClinicalPhase|imgt:Phase_M pubmed:15664918|imgt:isBibliographicReferenceOf|imgt:mAb_549 imgt:mAb_352|imgt:hasBibliographicReference|pubmed:648586 imgt:IgG1-kappa_1062|rdfs:label|IgG1-kappa_1062 imgt:mAb_716|imgt:inn_proposed_list|116 (2016) imgt:Cluster_of_Differentiation|rdfs:subClassOf|imgt:related_protein_of_immune_system imgt:Segment_641_1|imgt:has_rank|1 imgt:mAb_39|imgt:inn_number|8103 imgt:9541|imgt:isImgtStructureEntryOf|imgt:mAb_406 imgt:IgG4-kappa_1174|rdfs:label|IgG4-kappa_1174 imgt:StudyProduct_961a8cbb-97f6-330d-a900-59d58ea33047|imgt:hasClinicalPhase|imgt:Phase_M imgt:mAb_381|imgt:inn_proposed_list|105 (2011) imgt:mAb_367|imgt:inn_proposed_list|104 (2010) imgt:%5B(scFv-heavy-kappa)-IGHE-CH4%5D2_370|rdf:type|imgt:MAbReceptor imgt:Kidney_transplant_rejection_acute|rdfs:label|Kidney_transplant_rejection_acute imgt:Septic_shock|rdf:type|obo:NCIT_C185637 imgt:StructureType|rdf:type|owl:Class imgt:Fab%27-G1-nd_139|imgt:hasConstruct|imgt:Construct_139 _:Be24e72476432021dfc6c0010dd88c1ea|imgt:hasStatut|imgt:withdrawal imgt:HCV|imgt:isTargetOf|imgt:IgG1-nd_445 _:B6b52017858a98cf6df37c7b2aa9b6c5e|rdf:type|obo:NCIT_C53285 imgt:StudyProduct_55e7541c-3eab-3d0c-9193-6cda10fdcba2|rdfs:label|StudyProduct_55e7541c-3eab-3d0c-9193-6cda10fdcba2 imgt:IgG1-lambda_94|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-lambda.png imgt:gp5_tail-associated_lysozyme_(Pr352-575)|rdfs:label|gp5 tail-associated lysozyme (Pr352-575) imgt:half-G1-kappa_scFv-HEAVY-LAMBDA-h-CH2-CH3_920|rdfs:label|half-G1-kappa_scFv-HEAVY-LAMBDA-h-CH2-CH3_920 obo:NCIT_C166943|rdf:type|owl:Class obo:NCIT_C111039|rdf:type|owl:Class imgt:mAb_1148|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=1148 imgt:IgG1-kappa_788|obo:RO_0002162|imgt:Homsap imgt:TNFRSF10A|imgt:isTargetOf|imgt:%5BPROTEIN-PROTEIN%5D3_1297 imgt:mAb_236|rdf:type|obo:NCIT_C71694 imgt:StudyProduct_3458cf66-4c00-3212-b380-4a90977de6d5|imgt:hasClinicalIndication|imgt:Inflammatory_bowel_disease_(IBD) imgt:Product_4f24624b-491f-33db-a319-e376f0ccc76f|rdf:type|obo:NCIT_C51980 imgt:IgG4-kappa_999|imgt:hasConstruct|imgt:Construct_999 imgt:Colitis_ulcerative_(UC)|imgt:isClinicalIndicationOf|imgt:StudyProduct_1fd5cdac-9470-3ccd-b72e-92d15d0578c1 imgt:Product_a92db19e-acaf-3b18-8363-ab3546fcfaa5|imgt:commun_name|CTI 1601 imgt:Product_1e3e70cb-9c74-352f-bc15-c39c41590fbc|imgt:commun_name|rhuMab-E25 imgt:%5BCA_exendin-4-PEG_linker_%5D1-IGHG4_Fc_(Fragment_constant)|rdfs:label|[CA exendin-4 - PEG linker ]1 - IGHG4 Fc (Fragment constant) imgt:bispecific|imgt:isTargetOf|imgt:IgG1-kappa-%5BscFv%5D2-kappa_1196 imgt:mAb_298|rdfs:label|mAb_298 imgt:mAb_155|imgt:inn_name|atibuclimab imgt:Segment_713_1|obo:BFO_0000050|imgt:Construct_713 imgt:StudyProduct_f791dd12-d70e-318e-8882-69d14a827198|rdfs:label|StudyProduct_f791dd12-d70e-318e-8882-69d14a827198 obo:NCIT_C95798|rdfs:subClassOf|obo:NCIT_C1909 obo:NCIT_C128627|rdfs:subClassOf|obo:NCIT_C1909 imgt:Cancers_head_and_neck|imgt:isClinicalIndicationOf|imgt:StudyProduct_fe86e565-a1ca-3600-a752-28b347bac3f0 imgt:Product_1f73dd63-2db7-39af-95ec-0844134e2f55|rdf:type|obo:NCIT_C51980 imgt:Product_b902d379-45ba-3460-955c-938cf82600f1|rdfs:label|Product_b902d379-45ba-3460-955c-938cf82600f1 imgt:StudyProduct_14539647-c946-327c-a7a8-366cd8804b34|imgt:hasClinicalPhase|imgt:Phase_I/II imgt:Segment_1147_1|rdfs:label|Segment_1147_1 imgt:mAb_1170|imgt:inn_recommended_list|87 (2022) imgt:StudyProduct_c2402af5-16f0-3a7b-872f-e9498ca2173c|imgt:isStudyProductOf|imgt:Product_1ee293d6-44ea-3bcb-84c3-b34b51c264d4 imgt:IgG1-nd_105|obo:RO_0002162|imgt:Hum imgt:riabni™|rdfs:comment| RIABNI™ (rituximab-arrx) developed by Amgen (Thousand Oaks CA USA) approved by FDA on December 17 2020. (BLA) 761140 Same clinical indications as RITUXAN®. imgt:mAb_730|imgt:hasProduct|imgt:Product_bd27362a-84fc-3955-9a4f-86fb917213bb imgt:PEPTIDE-II-BETA|rdfs:label|PEPTIDE-II-BETA imgt:mAb_496|imgt:hasMabReceptor|imgt:IgG4-kappa_496 imgt:IgG1-kappa-4cys-drug2_1208|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa-4cys-drug2.png imgt:Product_ee7807fb-0636-3cbb-885a-583c3ec19047|imgt:hasStudyProduct|imgt:StudyProduct_ada272da-4f74-3360-85fc-7b3242f1c864 imgt:Product_bd27362a-84fc-3955-9a4f-86fb917213bb|imgt:commun_name|FE-999301 _:B856adb8d63029e0d1e41d853bd87d5f4|imgt:hasDesignation|imgt:Orphan_drug imgt:StudyProduct_f06ddced-f629-3fe1-8214-39aeb5883f40|imgt:hasExpressionSystem|imgt:_CHO-K1 _:B45a5b30edbe6b634d5a616060ed9f340|imgt:isDecisionOf|imgt:StudyProduct_4959e9db-1cfb-3ac4-8852-88fe6ff01da0 imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_89118c8d-7608-3f85-ac54-b4741cfaeeb4 imgt:mAb_142|rdf:type|imgt:INN imgt:StudyProduct_3e64b023-44c7-39c1-bd6a-db6275fc93ef|imgt:isStudyProductOf|imgt:Product_38dcb3a9-d366-365a-80b8-285719fdf525 imgt:Segment_180_1|rdfs:label|Segment_180_1 imgt:StudyProduct_a177bffd-41d0-3b50-81c9-05cfc8a63c34|imgt:development_technology| PENTRA® stable scFv imgt:SILENCER|skos:definition|inhibitor of gene transcription, in gDNA imgt:Clone_71|rdfs:label|Clone_71 imgt:StudyProduct_85da48ac-fe22-3b3d-8f2b-9949bbfef548|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells _:B5b6a51774c412d0134e9fb2ede4123d2|imgt:isDecisionOf|imgt:StudyProduct_8909d1e6-7acf-301c-83f0-55ae992caf23 imgt:Product_e759fefd-9101-3729-bd7b-5f4394e694e6|imgt:hasStudyProduct|imgt:StudyProduct_a7a76c17-2a4f-33d1-bfef-8a6f7152a99a imgt:mAb_943|imgt:hasImgtStructureEntry|imgt:11064 imgt:StudyProduct_07c0e9b8-92c6-3c90-8d18-9f8cad364ddf|imgt:isStudyProductOf|imgt:Product_d1ff3524-abf9-3a7a-93d3-8b514c80da83 imgt:Segment_304_1|rdfs:label|Segment_304_1 imgt:StudyProduct_ae79518a-58a0-3922-aa82-d07663205dac|imgt:isStudyProductOf|imgt:Product_f4071a62-44ea-3bb4-9bb6-5c68735042f7 imgt:StudyProduct_415b73aa-f37b-38eb-a7bf-4854835b0a6e|rdfs:label|StudyProduct_415b73aa-f37b-38eb-a7bf-4854835b0a6e imgt:Segment_581_1|imgt:hasImgtLabel|imgt:IGHG4 imgt:Product_9f6816fa-bfdc-3378-adc1-d4dd379f2138|imgt:isProducedBy|imgt:Takeda_Pharmaceuticals_USA_Inc imgt:TR-BETA-1|rdf:type|imgt:ChainLabels imgt:Type_1_diabetes|imgt:clinical_domain|Immunology imgt:mAb_525|imgt:inn_name|topsalysin imgt:mAb_828|imgt:inn_number|10557 obo:NCIT_C166849|rdfs:subClassOf|obo:NCIT_C1909 imgt:Product_846d926a-eaf9-39c4-851c-26956cdc70bd|imgt:hasStudyProduct|imgt:StudyProduct_09f8feed-06b9-3e49-a209-f1b52e9824ed imgt:StudyProduct_7b46fd68-1006-346a-9a43-1fe923d03303|imgt:hasClinicalPhase|imgt:Withdrawn imgt:StudyProduct_2f2dfbd2-681b-377f-b249-f5278e49229b|rdfs:label|StudyProduct_2f2dfbd2-681b-377f-b249-f5278e49229b _:B78b018e204cf063b7deb8f48ff88fa3f|imgt:isDecisionOf|imgt:StudyProduct_469a2965-c713-3c5d-9a91-b1a0403bb593 imgt:Clone_1189|imgt:clone_name|263-9E1 imgt:mAb_448|imgt:atc_link|http://www.whocc.no/atc_ddd_index/?code=C10AX13 imgt:Teva_Pharmaceutical_Industries_Ltd_(Cephalon)|rdfs:label|Teva Pharmaceutical Industries Ltd (Cephalon) imgt:StudyProduct_23514241-6079-3d3b-b77f-feedb96c88e7|imgt:hasClinicalPhase|imgt:Phase_III imgt:mAb_97|imgt:hasBiosimilar|imgt:herzuma™ imgt:mAb_747|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=747 imgt:StudyProduct_1e3d13d6-30e9-30d3-90c2-86212912f6e9|rdfs:label|StudyProduct_1e3d13d6-30e9-30d3-90c2-86212912f6e9 imgt:mAb_62|imgt:inn_name|labetuzumab imgt:mAb_387|rdf:type|imgt:INN imgt:StudyProduct_98500eba-73a3-3296-84e0-41682e43ea92|imgt:hasExpressionSystem|imgt:_CHO_DG44_(Chinese_Hamster_Ovary)_cells imgt:StudyProduct_c9cc9b8f-768e-34d7-8f47-1cb65379c659|imgt:hasClinicalPhase|imgt:Phase_III imgt:mAb_799|imgt:inn_proposed_list|118 (2017) imgt:SOBI_(Swedish_Orphan_Biovitrum_AB)|rdfs:comment|Stockholm , Sweden imgt:mAb_838|imgt:hasImgtStructureEntry|imgt:11418 imgt:ROR2|imgt:isTargetOf|imgt:IgG1-nd_883 imgt:is_confirmed|rdf:type|owl:AnnotationProperty imgt:StudyProduct_1bc2e1b0-235f-3fd7-895d-a9145c6ef8b1|rdf:type|obo:NCIT_C174271 _:Baee92742ed623105dc19170880020192|imgt:isDecisionOf|imgt:StudyProduct_0485cef8-ac82-346b-aa36-ae9f4bdb7da9 imgt:Vidara_Therapeutics_Ltd|rdfs:comment|Dublin , Ireland imgt:major_histocompatibility|rdfs:label|major_histocompatibility imgt:Segment_122_1|rdfs:label|Segment_122_1 imgt:mAb_222|imgt:hasProduct|imgt:Product_c311e57b-5fdf-3259-ae3a-0eab5583a035 imgt:StudyProduct_07e24932-2d26-39e7-a81c-1aecbcf488ab|imgt:application_type|Therapeutic imgt:StudyProduct_52aec5c4-8017-318a-be45-cf1c1533a0fa|imgt:isStudyProductOf|imgt:Product_8e8a1379-1ce0-3a6f-bd30-ded74b8a8b53 imgt:Product_3fc6bf12-9b61-329f-b867-eef0c9cd3e83|imgt:isProducedBy|imgt:Biogen_Inc imgt:mAb_539|imgt:hasMabReceptor|imgt:IgG1-kappa_539 imgt:mAb_60|imgt:hasMabReceptor|imgt:IgG1-kappa_60 imgt:mAb_517|rdf:type|imgt:INN imgt:Construct_434|imgt:hasImgtLabel|imgt:Fab-G1-kappa imgt:StudyProduct_60dfa53b-3345-3e41-ac21-3e5522a41ada|imgt:hasClinicalIndication|imgt:Neutropenia_chemotherapy-induced imgt:INTEGRIN-ALPHA-V|rdfs:label|INTEGRIN-ALPHA-V imgt:11797|rdf:type|obo:NCIT_C25402 imgt:StudyProduct_40b274c9-cbce-3d0d-9e45-f57a914447eb|imgt:hasClinicalIndication|imgt:Non-Hodgkin's_lymphoma_(NHL) imgt:Product_8f490102-cdea-34aa-b788-031461c9e8b8|imgt:commun_name|GSK-249320 imgt:mAb_481|imgt:inn_proposed_list|110 (2013) imgt:Product_dbff9770-a682-338f-b165-d9bc2b235a18|imgt:hasStudyProduct|imgt:StudyProduct_ccf31e01-b201-3b08-af3b-00b00171b720 imgt:mAb_358|imgt:inn_recommended_list|66 (2011) imgt:Apogenix_GmbH|rdf:type|obo:NCIT_C54131 imgt:mAb_205|rdf:type|obo:NCIT_C1909 imgt:IgG1-kappa-4cys-drug_773|imgt:hasConstruct|imgt:Construct_773 imgt:FR4|rdf:type|imgt:OldLabel imgt:%5BPDCD1LG2_(programmed_cell_death_1_ligand_2_B7DC_B7_dendritic_cell_molecule_PDL2_PD-L2_CD273)%5D2-IGHG1_Fc_(Fragment_constant)|rdfs:label|[PDCD1LG2 (programmed cell death 1 ligand 2, B7DC, B7 dendritic cell molecule, PDL2, PD-L2, CD273)]2 - IGHG1 Fc (Fragment constant) imgt:mAb_1135|rdf:type|imgt:INN imgt:StudyProduct_39400e8a-bdf7-30f6-8422-df948a831439|imgt:application_type|Therapeutic imgt:StudyProduct_28790f9e-30be-3e9c-b827-69ba060ccb1e|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_d008548d-93e9-3d46-80d4-fb8a78ec2641|imgt:application_type|Therapeutic imgt:StudyProduct_eb7dc2d9-89c1-3e59-9dd6-bbd47b396981|imgt:application_type|Therapeutic imgt:TREngineeredLabel|rdfs:subClassOf|imgt:StructureLabels imgt:7637|rdfs:label|7637 imgt:Product_827a202e-1f6c-316d-b5b0-b1ebd391a8c6|imgt:commun_name|AK-119 imgt:Product_1a51fc14-3298-3c36-ac40-80592fca6e44|imgt:isProducedBy|imgt:RemeGen_Ltd imgt:Killer_cell_immunoglobulin-like_receptor|rdfs:subClassOf|imgt:related_protein_of_immune_system imgt:PDCD1|imgt:isTargetOf|imgt:IgG4-kappa_1009 imgt:StudyProduct_d55443f5-070b-3435-acf3-6cb85f4b98c3|imgt:hasClinicalIndication|imgt:Crohn's_disease_(CD)_pediatric imgt:Construct_757|obo:BFO_0000051|imgt:Segment_757_1 imgt:Segment_395_3|obo:BFO_0000050|imgt:Construct_395 imgt:StudyProduct_7b8151d8-918e-34ec-8cf0-edac2cf91f88|imgt:isStudyProductOf|imgt:Product_d7375334-d0db-32f3-81ba-3cfa540a5cf4 imgt:Clone_244|rdf:type|obo:NCIT_C37925 imgt:Product_645dae0f-4159-327b-abf7-586dd4526f26|imgt:hasStudyProduct|imgt:StudyProduct_90ded528-5aeb-3f2f-ad4a-9fc2f1cbaa5c imgt:StudyProduct_380b9cf3-3dc6-38d6-955b-eb3e19145a38|imgt:isStudyProductOf|imgt:Product_e3009342-baa5-36fb-ad94-0743b8782e11 imgt:mAb_660|rdfs:label|mAb_660 imgt:StudyProduct_88b7f4da-6add-3303-94de-de5618010eff|imgt:application_type|Therapeutic imgt:StudyProduct_e4753962-2042-3ac1-845c-e6d1c1f142cd|imgt:hasClinicalPhase|imgt:Phase_I imgt:MH1-Alpha-MH1-C|imgt:hasChainTypeLevel|imgt:MH1-Alpha imgt:Segment_1113_1|imgt:hasImgtLabel|imgt:IL22 imgt:mAb_4|imgt:hasOriginClone|imgt:Clone_4 imgt:Product_e5ca6245-7a11-3390-b7de-6b5e8870b2ab|rdfs:label|Product_e5ca6245-7a11-3390-b7de-6b5e8870b2ab imgt:Product_37ffad37-3840-3cfc-a777-f523c62fcb62|imgt:isProducedBy|imgt:Genmab_A/S imgt:Product_e25f50c3-9b20-361d-9c46-198fe111366e|imgt:isProductOf|imgt:mAb_69 imgt:IgG4-nd_748|rdfs:comment|IgG4 - nd imgt:Product_8a665ccb-3040-3133-a43c-0685bb662383|imgt:commun_name|HuJ591-GS imgt:Construct_73|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Construct_277|imgt:isConstructOf|imgt:IgG2-kappa_277 imgt:mAb_775|imgt:clinical_trials|5 studies found, 2 recruiting imgt:Product_ae24c953-5ef0-3ff3-9d24-34f1a89ee93f|imgt:isProducedBy|imgt:Chugai_Pharmaceutical_Co_Ltd imgt:11061|imgt:isImgtStructureEntryOf|imgt:mAb_972 imgt:Product_6956a607-0f47-33a7-bdff-92b6edef93c2|imgt:isProductOf|imgt:mAb_701 imgt:Product_b6db4dcb-3841-3302-afce-13d1e43b067e|imgt:commun_name|CC49 imgt:mAb_936|rdf:type|imgt:INN _:B55e7025d7bc807aa110512a4ea44fe81|rdf:type|obo:NCIT_C53285 imgt:mAb_1016|imgt:inn_recommended_list|84 (2020) imgt:mAb_1021|imgt:inn_name|ongericimab imgt:Construct_886|rdf:type|imgt:Construct imgt:StudyProduct_8cca4431-f89f-339a-a04a-5b748a79a85b|imgt:development_technology| MorphoSys's HuCAL® phage library imgt:Product_2afcb1d2-59f0-3021-b52c-19a197ec5ec9|imgt:commun_name|HFB-30132A imgt:StudyProduct_141c27b7-1f12-324c-9e37-98bea60711bf|imgt:hasDecision|_:B4b7a5f03b3e17b50eb4a4c4ac938b307 imgt:StudyProduct_a4335940-34a0-3627-b2ea-b3c189aa7893|imgt:hasClinicalIndication|imgt:Lymphoma_B_cell imgt:mAb_1035|rdfs:label|mAb_1035 imgt:Segment_472_1|imgt:has_rank|1 imgt:Product_0545ddda-e76f-30e4-a4e8-f0c02500c6cb|imgt:hasStudyProduct|imgt:StudyProduct_a7ca4fb3-2fbe-3bab-a42f-61bb209d9eb9 imgt:StudyProduct_e0cab35b-55c2-3e25-b272-91ca7cd65484|rdf:type|obo:NCIT_C174271 imgt:Product_07e0d9b7-856b-34d9-845d-70d1a61bef86|imgt:isProductOf|imgt:mAb_832 imgt:EMA|rdfs:label|EMA (European Medicines Agency for the Evaluation of Medical Products) imgt:StudyProduct_3d3b1b00-4296-3c01-9e34-6a5b725dbe90|imgt:hasDecision|_:Baef38c3255efc6a164d9f55101f6380e imgt:ITGAE_ITGB7|rdfs:label|ITGAE_ITGB7 imgt:StudyProduct_735c0bc0-0411-315c-9537-87ebbfd1c806|imgt:development_technology| imPACT Isolation Technology® CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 technology imgt:StudyProduct_ec41c831-5a12-3940-835f-540bd8464ab2|rdf:type|obo:NCIT_C174271 imgt:Product_80543f95-22b7-3761-a574-ef4df0802d70|imgt:commun_name|DS 992 imgt:Segment_596_1|imgt:hasImgtLabel|imgt:Fab-G1-kappa imgt:mAb_256|rdf:type|imgt:INN imgt:Product_c23cf240-f365-3619-b7f6-936b4aae6390|imgt:commun_name|MDX-447 imgt:StudyProduct_65b9a184-d1f1-3c9c-b489-5940b2861c47|imgt:application_type|Therapeutic imgt:IL8|obo:RO_0002162|imgt:Homsap imgt:3EOB|rdf:type|obo:NCIT_C25402 imgt:StudyProduct_e18346b4-c502-3a24-9514-3f9ecb2d5d74|imgt:hasDecision|_:Ba9ef72b9d6c9661d4a7f82bd9aee9a1a imgt:Construct_84|imgt:isConstructOf|imgt:Fab-G1-kappa_84 imgt:StudyProduct_5238c8b8-e8b4-32d3-a68f-157633d0b23b|imgt:hasClinicalIndication|imgt:Asthma imgt:Construct_1215|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:_CHO_(Chinese_Hamster_Ovary)_glutamine_synthetase_(GS)_deficient_cells_|imgt:isExpressionSystemOf|imgt:StudyProduct_c87582a0-902a-327a-9e8b-0bb1d2a331d6 imgt:Product_dc0aef01-f52d-3832-923a-55c9be5361e7|imgt:hasStudyProduct|imgt:StudyProduct_8884105a-95a2-34a2-9f41-9dd1caaf8643 imgt:mAb_361|imgt:hasProduct|imgt:Product_65ff39db-abc8-3fea-a44b-33c9a2a782e2 imgt:Product_f21edd5d-c119-3b27-a5be-d51a4f2ba15a|rdf:type|obo:NCIT_C51980 imgt:Clone_1243|imgt:isOriginCloneOf|imgt:mAb_1243 imgt:Product_76a068f8-e304-3746-aabc-b40c1b23f548|imgt:isProductOf|imgt:mAb_1185 imgt:mAb_867|imgt:inn_recommended_list|81 (2019) imgt:Product_c4b5a4f9-01ee-3823-90ef-f047993fe32e|imgt:commun_name|Peg-Intron A imgt:StudyProduct_f254860d-8ce1-3727-ae18-0a29572ecbcb|rdf:type|obo:NCIT_C174271 imgt:D-J-REGION|rdf:type|imgt:ComposedRegionLabel imgt:StudyProduct_0e676733-e241-3eff-a6d5-e87e8b162340|imgt:application_type|Therapeutic imgt:Construct_1134|imgt:hasImgtLabel|imgt:IgG1-kappa obo:NCIT_C175144|rdf:type|owl:Class _:B789f5cd1d5fe15d7a8ae5c89043dde22|dc:date|2016-12-12 imgt:Segment_501_1|rdfs:label|Segment_501_1 imgt:Product_ae524b04-99c4-38a9-90a9-969c902b7d04|rdfs:label|Product_ae524b04-99c4-38a9-90a9-969c902b7d04 imgt:Autoimmune_diseases_CD4_mediated|rdfs:label|Autoimmune_diseases_CD4_mediated _:Bf1e0d381a9c06cbe1fb2a3997b937106|rdf:type|obo:NCIT_C53285 imgt:StudyProduct_e15b2151-8965-350c-87ec-1241381bb101|rdfs:label|StudyProduct_e15b2151-8965-350c-87ec-1241381bb101 imgt:StudyProduct_cff2ed84-8d7a-3c61-9a87-baf0ef1d3d9c|imgt:hasClinicalPhase|imgt:Phase_I/II imgt:Product_972e9945-c489-3173-8e5c-a341bfd8de2d|imgt:commun_name|HLX-07 _:Bb361c75360909c8d70e95248a223b73e|rdf:type|obo:NCIT_C53285 imgt:Product_ce822f79-054d-3661-8bf4-37f73f52daa5|rdf:type|obo:NCIT_C51980 imgt:mAb_962|rdf:type|obo:NCIT_C119615 imgt:L-V-D-sequence|rdf:type|imgt:Molecule_EntityType imgt:IgG1-kappa-4lys-drug_967|rdfs:label|IgG1-kappa-4lys-drug_967 imgt:IgG1-kappa_47|obo:RO_0002162|imgt:Hum imgt:CPCA_PEPTIDE-PEG-FC_673|rdf:type|imgt:MAbReceptor imgt:(VH-CH2-CH3)2_S_934|imgt:hasConstruct|imgt:Construct_934 imgt:TOXIN_BIG-PROTEIN_825|imgt:isMabReceptorOf|imgt:mAb_825 imgt:Product_dbe70051-84bf-318e-a2df-870d1dbb932a|imgt:commun_name|GNC-038 imgt:Product_f0c3d7ec-73fc-3e13-804c-c87d05009d94|imgt:isProductOf|imgt:mAb_859 imgt:Segment_1190_1|rdf:type|imgt:Segment imgt:mAb_741|imgt:imgt_note| peginterferon alfacon-2 is a recombinant not-naturally occurring type-I interferon. Its amino acid sequence (of 171 AA including the additional motif GSGGG at the N-terminal end) differs from 7559 interferon alfacon-1 (L77)(R39), another recombinant not-naturally occurring type-I interferon, by the additional motif GSGGG (instead of M) and, based on the P01563-1 (IFNA2) numbering, R143 (instead of K) and E188 (instead of D). Interestingly R143 and E188 are found in IFNA2. imgt:Crohn's_disease_(CD)|imgt:isClinicalIndicationOf|imgt:StudyProduct_9801dc10-1bf3-3726-94d1-aaa04acece27 imgt:StudyProduct_fd6de48f-4814-343e-a035-1badad487766|rdf:type|obo:NCIT_C174271 imgt:mAb_562|imgt:clinical_trials|16 studies found, 7 recruiting imgt:StudyProduct_e1e1e9d8-aedb-3766-8260-e6e33f142b5e|rdf:type|obo:NCIT_C174271 imgt:Construct_159|rdf:type|imgt:Construct imgt:mAb_604|imgt:inn_recommended_list|76 (2016) imgt:Product_785b96d0-9949-370c-8ff7-5e6014018922|imgt:hasStudyProduct|imgt:StudyProduct_68039b7e-3fda-329f-8431-808faacb5383 _:Bca1e18b35e9fcc5d12e998a15776e61e|imgt:isDecidedBy|imgt:FDA imgt:mAb_656|imgt:hasMabReceptor|imgt:IgG1-lambda-4lys-drug_656 imgt:StudyProduct_7ffe0f44-2268-3f15-8841-227da7ec3971|imgt:development_technology| VelocImmune® imgt:Product_795cef08-7412-3081-a82a-eac1a4e6d317|imgt:hasStudyProduct|imgt:StudyProduct_f4519ce4-aa6b-3730-8911-9251055bc0be imgt:IgG1-kappa_410|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:StudyProduct_6bde1980-495c-3cc6-ad93-882c2bb2a125|imgt:hasClinicalIndication|imgt:Crohn's_disease_(CD) imgt:Product_d946876c-2d5b-39e7-947d-0c1325d80a31|rdf:type|obo:NCIT_C51980 imgt:StudyProduct_f8a4c682-c797-36a3-8307-cf75265eec3a|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_5fdbf507-352c-34e8-a0b0-00c7a6c7863e|imgt:application_type|Therapeutic imgt:mAb_98|imgt:hasOriginClone|imgt:Clone_98 imgt:Construct_886|obo:BFO_0000051|imgt:Segment_886_1 imgt:Product_354f3505-9da0-3654-9a32-e7ed2530f686|imgt:hasStudyProduct|imgt:StudyProduct_3a66b5f8-3b74-3e8e-838b-da3893b82e7e imgt:StudyProduct_7f8ce214-c647-389c-b6aa-bcbcbdad0bf8|rdf:type|obo:NCIT_C174271 imgt:mAb_746|rdf:type|obo:NCIT_C1909 imgt:StudyProduct_a17be910-448c-39cd-9135-1e69cc88ffe0|rdfs:label|StudyProduct_a17be910-448c-39cd-9135-1e69cc88ffe0 imgt:Segment_1025_1|rdf:type|imgt:Segment imgt:Segment_839_1|imgt:hasImgtLabel|imgt:IgG-nd imgt:mAb_274|imgt:hasOriginClone|imgt:Clone_274 imgt:ADC_Therapeutics|rdfs:comment|Epalinges , Switzerland obo:NCIT_C140427|rdf:type|owl:Class imgt:Osteoarthritis_(OA)|imgt:isClinicalIndicationOf|imgt:StudyProduct_e0cab35b-55c2-3e25-b272-91ca7cd65484 imgt:StudyProduct_7ffe0f44-2268-3f15-8841-227da7ec3971|imgt:application_type|Therapeutic imgt:Segment_696_2|obo:BFO_0000050|imgt:Construct_696 imgt:Construct_785|imgt:hasImgtLabel|imgt:IgG2-kappa imgt:Baxter_BioScience|rdf:type|obo:NCIT_C54131 imgt:Cancers|imgt:isClinicalIndicationOf|imgt:StudyProduct_2250d796-5209-3656-9e42-4c6269186b55 imgt:Product_4d3d1c57-c33d-3fb9-a04f-cdb7a0a344c2|imgt:hasStudyProduct|imgt:StudyProduct_5bd00c15-5132-3b98-92ad-994980aadd96 imgt:mAb_196|imgt:inn_number|8499 imgt:mAb_1029|imgt:hasProduct|imgt:Product_23bdc528-2f16-3a86-9e4c-0033da4742f2 _:B38702e6f12949b9f8d140ec00169b1a8|imgt:isDecisionOf|imgt:StudyProduct_9499cb2a-4142-3f81-ae02-a71d5a9ec790 imgt:StudyProduct_50c57a82-84df-34c5-bed8-09d115373427|imgt:application_type|Therapeutic obo:NCIT_C171838|rdfs:subClassOf|obo:NCIT_C1909 imgt:three|rdfs:label|partial_3p imgt:Segment_1178_1|obo:BFO_0000050|imgt:Construct_1178 imgt:Segment_199_1|obo:BFO_0000050|imgt:Construct_199 imgt:D-transcript|imgt:hasConfigurationType|imgt:G imgt:IgG1-kappa_1217|imgt:isMabReceptorOf|imgt:mAb_1217 imgt:IgG1-kappa_197|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:IL2RB|imgt:isTargetOf|imgt:PROTEIN_1DOMAIN-PEG_871 imgt:GFRA3|obo:RO_0002162|imgt:Homsap imgt:Segment_736_1|imgt:hasImgtLabel|imgt:IgG-nd imgt:Product_c7f1d535-33e6-32f8-8320-06c648b7ccc4|imgt:commun_name|h16f imgt:Product_1720d0b5-b5f3-382f-8160-d326672865c5|rdfs:label|Product_1720d0b5-b5f3-382f-8160-d326672865c5 imgt:Construct_30|obo:BFO_0000051|imgt:Segment_30_1 imgt:mAb_84|imgt:centerwatch_link|http://www.centerwatch.com/drug-information/fda-approvals/drug-details.aspx?DrugID=904 imgt:Segment_980_1|imgt:has_rank|1 imgt:mAb_1022|imgt:inn_recommended_list|84 (2020) imgt:Clone_221|obo:RO_0002162|imgt:Musmus imgt:TNC-ALB|skos:definition|Chain or receptor comprising TNC and ALB imgt:Product_20a2a201-0133-34db-9a15-2bab3ce59099|rdf:type|obo:NCIT_C51980 imgt:mAb_384|imgt:hasProduct|imgt:Product_4fca6fa6-19ec-3b75-967c-377d6768e2ef imgt:mAb_97|imgt:inn_recommended_list|40 (1998) imgt:mAb_256|imgt:hasMabReceptor|imgt:IgG4-nd_256 imgt:Segment_673_1|imgt:has_rank|1 imgt:StudyProduct_4ea32c8c-1ddd-3e99-afe2-65af981e4c20|imgt:hasClinicalIndication|imgt:Tumor_necrosis_factor_receptor_associated_periodic_syndrome_(TRAPS) imgt:amsparity|rdf:type|obo:NCIT_C156644 imgt:Product_5dea998c-cfea-32c4-a7bd-01fd1839b7c7|imgt:isProducedBy|imgt:Pfizer imgt:FUSION-TNFRSF1A-GAMMA-1|rdfs:label|FUSION-TNFRSF1A-GAMMA-1 imgt:11351|rdf:type|obo:NCIT_C25402 _:B58b07bc4f64201d065d0bedce845fa5d|imgt:isDecidedBy|imgt:FDA imgt:Fab-G1-kappa-TOXIN_BIG_236|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/Fab-G1-kappa-TOXIN_BIG.png imgt:Segment_460_1|obo:BFO_0000050|imgt:Construct_460 imgt:Product_703c4b0d-f69e-3fe3-b385-600d9224c3b0|imgt:commun_name|SCD4(178)-PE40 imgt:IgG1-kappa_1005|obo:RO_0002162|imgt:Hum imgt:cinnovex®|rdfs:comment| CINNOVEX® developed by Biogen Inc. (Cambridge MA USA) Biosimilar of AVONEX® 1996. imgt:FAB-ALPHA-2_KAPPA|rdfs:label|FAB-ALPHA-2_KAPPA imgt:Segment_706_1|rdfs:label|Segment_706_1 imgt:Product_b6db4dcb-3841-3302-afce-13d1e43b067e|imgt:comercial_name|RIGScan™ imgt:Segment_1196_1|rdfs:label|Segment_1196_1 imgt:IgG4-kappa_33|imgt:hasMolecularComponent|imgt:IG imgt:9983|rdf:type|obo:NCIT_C25402 imgt:StudyProduct_a4e4cb9c-3386-3914-b91c-5b6b4e2f790e|imgt:isStudyProductOf|imgt:Product_f4f50a15-6583-34a5-bbcd-eec5a6853ba0 imgt:StudyProduct_f375ecf3-18aa-381c-a6b2-03574a674c16|imgt:hasClinicalPhase|imgt:Preclinical imgt:mAb_1278|imgt:inn_number|11933 imgt:Roche_F_Hoffmann-La_Roche_Ltd|imgt:produces|imgt:Product_ae5845b7-abc5-32d8-ae41-00b809fc6a7b imgt:mAb_257|rdfs:label|mAb_257 imgt:10436|imgt:isImgtStructureEntryOf|imgt:mAb_715 imgt:mAb_679|imgt:imgt_note| MGD006 Poster presentation at 2014 SITC SCFV-LAMBDA-HEAVY comprises V-LAMBDA anti-CD3E fused to VH anti-IL3RA fused to E-coil motif.\r SCFV-KAPPA-HEAVY comprises V-KAPPA anti-IL3RA fused to VH anti-CD3E fused to K-coil motif. In IMGT/2Dstructure-DB, ND indicates a linker GGCGGG followed by the E-coil or K-coil motif, respectively. imgt:Segment_503_1|rdf:type|imgt:Segment imgt:mAb_664|imgt:inn_number|10425 imgt:Product_8e3c67b3-d78e-3d94-8195-ee6b6b36123d|rdf:type|obo:NCIT_C51980 imgt:Construct_392|obo:BFO_0000051|imgt:Segment_392_1 _:B9b176b31cfffc9584abd4d6791af9041|imgt:isDecidedBy|imgt:FDA imgt:Clone_1132|imgt:clone_name|ESBA1622 imgt:StudyProduct_a3f0ef7c-24c2-3746-901e-38acdd728455|rdfs:label|StudyProduct_a3f0ef7c-24c2-3746-901e-38acdd728455 imgt:peptidyl_linker|rdf:type|imgt:SegmentLabels imgt:StudyProduct_1884c1fa-e53a-3bd2-b507-eae4c4c1906e|imgt:hasClinicalPhase|imgt:Phase_III imgt:%5BCD58_(LFA3_lymphocyte_function_associated_antigen_3)%5D2-IGHG1_Fc_(Fragment_constant)|rdf:type|imgt:ConstructLabels imgt:mAb_1267|imgt:hasOriginClone|imgt:Clone_1267 imgt:phosphatidylserine|imgt:isTargetOf|imgt:IgG1-kappa_149 imgt:Segment_489_1|obo:BFO_0000050|imgt:Construct_489 imgt:CH2-IGHG1|rdfs:label|CH2-IGHG1 imgt:StudyProduct_3e64b023-44c7-39c1-bd6a-db6275fc93ef|rdf:type|obo:NCIT_C174271 imgt:Product_a16baed9-ed2e-396b-98d0-5ddeb1eb104c|imgt:hasStudyProduct|imgt:StudyProduct_300d8bb5-c675-3ea9-9f98-67e2fc5149f0 imgt:StudyProduct_3e8e545e-eddd-3e3f-8a98-e684875993b4|rdfs:label|StudyProduct_3e8e545e-eddd-3e3f-8a98-e684875993b4 imgt:IgM-kappa_129|obo:RO_0002162|imgt:Musmus imgt:StudyProduct_9fb25145-bfe7-33f6-9117-a8a9ca677ff6|rdfs:label|StudyProduct_9fb25145-bfe7-33f6-9117-a8a9ca677ff6 pubmed:8652509|dc:date|1996 imgt:Product_aeb9b1ac-6efd-336f-af32-ebc0ea62dbd3|imgt:isProductOf|imgt:mAb_1250 imgt:Diabetes_mellitus_(DM)|rdfs:label|Diabetes_mellitus_(DM) imgt:Construct_961|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Eosinophilic_granulomatosis_with_polyangiitis_(EGPA)_formerly_known_as_Churg-Strauss_Syndrome|imgt:isClinicalIndicationOf|imgt:StudyProduct_3bfa1123-ebd5-3f43-932e-509b7c03d0cb imgt:StudyProduct_008a7f4c-49ec-36e6-9341-cf3c5a429916|rdfs:label|StudyProduct_008a7f4c-49ec-36e6-9341-cf3c5a429916 obo:NCIT_C48429|rdf:type|owl:Class imgt:Product_bf01e52c-681c-3e27-a65a-7e56b7753697|rdf:type|obo:NCIT_C51980 imgt:Chronic_Obstructive_Pulmonary_Disease_(COPD)|imgt:isClinicalIndicationOf|imgt:StudyProduct_8c392433-f79a-3598-bd21-e7d09a590193 imgt:Product_fde2e7c8-3ef2-3b15-af78-d71e7f78ed48|imgt:isProductOf|imgt:mAb_935 imgt:StudyProduct_b3b77be6-ab94-3cd6-9fdf-6223c76c8192|imgt:hasClinicalPhase|imgt:Phase_II imgt:Clone_589|obo:RO_0002162|imgt:Musmus imgt:mAb_1172|rdf:type|obo:NCIT_C162504 imgt:SIGNAL-JOINT|rdf:type|imgt:IntronConceptLabel imgt:Segment_499_1|rdfs:label|Segment_499_1 imgt:Segment_787_1|obo:BFO_0000050|imgt:Construct_787 imgt:StudyProduct_5dfe30be-eda1-3639-8dea-4939175ff170|imgt:hasClinicalPhase|imgt:Phase_I obo:NCIT_C136465|rdf:type|owl:Class imgt:StudyProduct_903c06d0-e1c4-316e-90d5-030f27a07eae|imgt:hasClinicalIndication|imgt:Dry_eye_(DE)_syndrome imgt:Genexine|rdf:type|obo:NCIT_C54131 imgt:Construct_1256|rdfs:label|Construct_1256 _:Bdbecb30bf22c2eec770ca7ab3a330a75|dc:date|2017-12-01 imgt:Construct_400|imgt:isConstructOf|imgt:IgG1-kappa_400 imgt:StudyProduct_02a5d74c-0f83-3ab4-bf1e-8261d9c461d3|rdf:type|obo:NCIT_C174271 imgt:Construct_705|obo:BFO_0000051|imgt:Segment_705_1 imgt:mAb_203|rdfs:label|mAb_203 imgt:UTRLabel|rdfs:label|UTRLabel imgt:scFv-kappa-heavy-CD8A_(CO-TM)-TNFRSF9_(CY)-CD247_828|imgt:fused_with| CD8A (CO-TM) - TNFRSF9 (CY1) - CD247 (CY2) (1:1) _:B57d7d833ee9aa1aa1dd01f63ddd65300|imgt:hasDesignation|imgt:Orphan_drug imgt:Clone_85|obo:RO_0002162|imgt:Musmus imgt:mAb_279|imgt:hasMabReceptor|imgt:IgG4-nd_279 imgt:mAb_673|imgt:hasProduct|imgt:Product_89f1ae82-3fb5-3b22-b31b-63474999c711 imgt:Product_dd85beae-6045-31b2-a421-cb8d4d3eea73|imgt:commun_name|Y-90 Zevalin imgt:IgG1-kappa-2cys-drug_774|imgt:hasMolecularComponent|imgt:IG imgt:StudyProduct_139c25e2-58bd-3782-846d-1abdc865d72e|rdfs:label|StudyProduct_139c25e2-58bd-3782-846d-1abdc865d72e imgt:Segment_1127_1|rdf:type|imgt:Segment imgt:StudyProduct_14c43a92-6218-3954-aa5b-a9e5fa1474b2|rdf:type|obo:NCIT_C174271 imgt:IgG1-kappa_913|obo:RO_0002162|imgt:Homsap imgt:Clone_274|obo:RO_0002162|imgt:Musmus imgt:Clone_254|rdfs:label|Clone_254 imgt:StudyProduct_fa6b81e8-5c93-37a0-a3d3-b348d1400e90|rdf:type|obo:NCIT_C174271 _:Baf347226fbf0b9f9efb69ba637202e1c|imgt:hasStatut|imgt:approval imgt:Forty_Seven_Inc|rdfs:comment|Menlo Park , USA imgt:FAB-MU_KAPPA|rdfs:label|FAB-MU_KAPPA imgt:Segment_415_1|rdfs:label|Segment_415_1 imgt:StudyProduct_cfc283b3-c688-3da8-ad58-33f8486263eb|imgt:isStudyProductOf|imgt:Product_e45601ef-1642-347e-acf6-1d5dc5b29091 imgt:Clone_181|imgt:isOriginCloneOf|imgt:mAb_181 imgt:Product_4c11ab27-05af-3a09-8d86-91e6154e14c1|imgt:commun_name|RG7935 imgt:Segment_794_1|rdfs:label|Segment_794_1 imgt:Canlupfam_IL31|imgt:isTargetOf|imgt:IgG2-kappa_2bridges_527 imgt:StudyProduct_115bc04d-cd5b-3146-9ec7-c78e72875181|imgt:application_type|Therapeutic imgt:Segment_857_1|rdfs:label|Segment_857_1 imgt:IgG1-kappa_294|imgt:hasMolecularComponent|imgt:IG imgt:mAb_1123|rdfs:label|mAb_1123 imgt:F9_(Pr29-46)|rdfs:label|F9 (Pr29-46) imgt:mAb_654|imgt:hasProduct|imgt:Product_ceac1823-08ff-3c1e-9927-2979bfb061fb imgt:Product_31d88f86-f890-3c06-9160-b268bfdcdad5|imgt:hasStudyProduct|imgt:StudyProduct_aac27e2f-8d9c-3b3b-92ec-b3a6372b757f imgt:ANX3_(Pr160-243)|skos:definition|Annexin imgt:8653|imgt:isImgtStructureEntryOf|imgt:mAb_249 imgt:FGF23|rdf:type|obo:NCIT_C25702 imgt:StudyProduct_6d2b9607-0f54-334f-9a71-2538aca2b433|imgt:application_type|Therapeutic imgt:IgG2-kappa_415|http://semanticscience.org/resource/SIO_000291|imgt:DLL4 imgt:mAb_322|imgt:hasProduct|imgt:Product_b0734cf2-486f-3853-a05a-854676784ad9 imgt:IgG1-kappa_1204|rdfs:comment|IgG1 - kappa imgt:Product_d4257b3b-e73f-39d7-9439-417ecbb213f1|rdfs:label|Product_d4257b3b-e73f-39d7-9439-417ecbb213f1 obo:NCIT_C171742|rdf:type|owl:Class imgt:Severe_acute_respiratory_syndrome_coronavirus_2_(SARS-CoV-2)|imgt:isTargetOf|imgt:IgG1-kappa_1271 imgt:mAb_134|imgt:inn_recommended_list|36 (1996) _:Ba11636cdedbc5ad5983b09dc7eb3b932|rdf:type|obo:NCIT_C53285 imgt:StudyProduct_c327e66b-2e9d-37e5-bae8-109180ea140d|imgt:hasExpressionSystem|imgt:_COS_cells_transient_expressionNS0_mouse_myeloma_cells imgt:IGF1R|imgt:isTargetOf|imgt:IgG1-kappa-4cys-drug3_1134 _:Bf4267e4b79e1f337a0c27317ec2776fb|rdf:type|obo:NCIT_C53285 imgt:Segment_1051_2|imgt:hasImgtLabel|imgt:CTP_(C-terminal_peptide_of_the_β-subunit_of_human_chorionic_gonadotropin_(hCG)) _:B6472abf3fbdb645297edcd4cbf0d37d4|rdf:type|obo:NCIT_C53285 imgt:CD22|imgt:isTargetOf|imgt:Fv-disulfide-stabilized-heavy-TOXIN_BIG-kappa_198 imgt:mAb_612|imgt:hasImgtStructureEntry|imgt:9918 imgt:TR-Gamma-2_Delta|rdfs:label|TR-Gamma-2_Delta imgt:mAb_388|imgt:inn_name|dalantercept imgt:mAb_1248|rdf:type|obo:NCIT_C1909 imgt:Segment_244_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:StudyProduct_e9fdc1ce-df4c-37d6-b2ed-adbf4f65626c|imgt:hasClinicalIndication|imgt:Hemophilia_A imgt:Segment_673_3|rdfs:label|Segment_673_3 _:B2cbdd5a75de68cf17f0c6f365f022ab3|imgt:isDecisionOf|imgt:StudyProduct_8bb54045-8ad1-3474-9b0d-c2ec2a570bdb imgt:DIPHTERIATOXIN-IL2|rdfs:label|DIPHTERIATOXIN-IL2 _:Bd60495b8d114f1336f51bd29cf958395|imgt:isDecidedBy|imgt:FDA imgt:Cancers|imgt:isClinicalIndicationOf|imgt:StudyProduct_b887cbbf-4c35-3532-a08c-9535399ee8ff imgt:Dragon_Sail_Pharmaceutical_Co_Ltd|rdfs:comment|null , China imgt:StudyProduct_d326469e-6f88-3537-a40c-8ab4d0953fec|imgt:hasDecision|_:B8e267ffc56112caa5eb8b8fd6dfde1d4 imgt:mAb_939|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=939 imgt:StudyProduct_f4519ce4-aa6b-3730-8911-9251055bc0be|rdfs:label|StudyProduct_f4519ce4-aa6b-3730-8911-9251055bc0be imgt:StudyProduct_ab7d8ffc-9070-3c4e-afbf-5efec0fbe8cc|imgt:hasClinicalPhase|imgt:Phase_I imgt:FUSION-GLP1-GAMMA-4|skos:definition|GLP1 fused with G4 H-CH2-CH3 imgt:mAb_933|rdf:type|obo:NCIT_C1909 imgt:StudyProduct_84e6c145-458d-3fba-8bb2-39652fa5f0b5|imgt:hasClinicalPhase|imgt:Phase_I imgt:11122|imgt:isImgtStructureEntryOf|imgt:mAb_974 imgt:FV-ALPHA_BETA|rdf:type|imgt:StructureLabels imgt:Product_97d744b1-4bb8-3b77-b6fc-10c38a6bca9a|imgt:isProducedBy|imgt:Teva_Pharmaceutical_Industries_Ltd_(Cephalon) imgt:StudyProduct_2c9ec9d9-557a-3a85-9956-f8a34c113f10|imgt:hasClinicalIndication|imgt:Lymphoma_follicular_(FL) imgt:Segment_989_1|imgt:hasImgtLabel|imgt:IgG2a-nd imgt:StudyProduct_f55e0ab5-a277-3480-81b4-9981b86c5f54|imgt:hasClinicalIndication|imgt:Gas_gangrene imgt:IgG1-kappa_603|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:mAb_119|imgt:atc_link|http://www.whocc.no/atc_ddd_index/?code=L01XC01 imgt:5ALB|rdf:type|obo:NCIT_C25402 imgt:IgG1-kappa_1193|rdfs:comment|IgG1 - kappa imgt:TACSTD2|imgt:isTargetOf|imgt:IgG1-kappa-6cys-drug_559 imgt:StudyProduct_0584e143-d0b0-3644-8317-76cde6765c24|rdfs:label|StudyProduct_0584e143-d0b0-3644-8317-76cde6765c24 imgt:Segment_399_1|obo:RO_0002162|imgt:Myctubvarbov imgt:IgG4-nd_3|rdfs:comment|IgG4 - nd imgt:isBibliographicReferenceOf|rdf:type|owl:ObjectProperty imgt:mAb_1126|imgt:inn_number|11582 imgt:mAb_167|imgt:hasOriginClone|imgt:Clone_167 imgt:isConstructOf|rdf:type|owl:ObjectProperty imgt:Segment_393_1|imgt:hasImgtLabel|imgt:IGHG1 imgt:IL12B|rdfs:label|IL12B imgt:Genentech_Inc|imgt:produces|imgt:Product_9988ec5b-fd7a-325e-bd3f-39829a8fc36d imgt:mAb_950|imgt:inn_recommended_list|83 (2020) imgt:StudyProduct_1262459b-5fb7-3613-be73-bb5ee75f51e3|imgt:isStudyProductOf|imgt:Product_e5f2774f-12a5-3152-ba54-ccfdc2d08d29 imgt:Crohn's_disease_(CD)|imgt:isClinicalIndicationOf|imgt:StudyProduct_141c27b7-1f12-324c-9e37-98bea60711bf imgt:Product_02550586-7a1b-3018-bf60-0ad7c06c9f86|imgt:hasStudyProduct|imgt:StudyProduct_26216034-05b3-3a88-9946-c371c77b099c imgt:mAb_998|imgt:imgt_note| MOA: substitute for endogenous ectodysplasin A (EDA), a protein missing or mutated in XLHED (X-linked hypohidrotic ectodermal dysplasia). imgt:mAb_470|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=470 obo:NCIT_C147523|rdf:type|owl:Class imgt:Product_befef2c3-f6db-347b-ad59-89c3a928207e|rdf:type|obo:NCIT_C51980 imgt:StudyProduct_01521ddb-ecdc-3ff5-8659-d40f72c1207d|imgt:isStudyProductOf|imgt:Product_1a2d7afe-fb0d-33fe-9798-879a917f9548 imgt:mAb_631|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=631 imgt:Construct_175|rdf:type|imgt:Construct imgt:Product_a4697031-63a6-3436-9c6f-ea24c369e4df|imgt:commun_name|5c8 imgt:Segment_780_1|obo:BFO_0000050|imgt:Construct_780 imgt:StudyProduct_736cc71f-a7c5-3b58-92bd-457be9650811|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_ba3910c4-6e0c-3086-b1d5-db737041e363|imgt:hasDecision|_:B617de892405ddf649fd0e2256d61f54f imgt:StudyProduct_bb80f2f4-20e6-3b38-9f95-aa0392d89512|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:mAb_777|imgt:inn_recommended_list|79 (2018) imgt:mAb_1290|imgt:inn_proposed_list|126 (2022) imgt:Severe_acute_respiratory_syndrome_(SARS)_infection|rdf:type|obo:NCIT_C185637 imgt:Clone_1198|imgt:isOriginCloneOf|imgt:mAb_1198 imgt:Construct_323|imgt:hasImgtLabel|imgt:IgG1-lambda bibo:Article|rdfs:label|Article imgt:Construct_143|imgt:isConstructOf|imgt:IgG1-kappa_143 imgt:Product_09c01ca5-976f-3de9-81cb-3dc784cbc65f|imgt:isProducedBy|imgt:Rhein-Minapharm imgt:IgG1-nd_46|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-nd.png pubmed:21154167|rdfs:label|PMID_21154167 imgt:StudyProduct_fb049423-02a4-3c71-b284-29932cb38182|imgt:application_type|Therapeutic imgt:StudyProduct_975e1353-8fe5-30e5-bb01-d75eb6760ec9|rdf:type|obo:NCIT_C174271 imgt:Product_b2cc8073-23cf-353d-8ced-550f89677c37|rdfs:label|Product_b2cc8073-23cf-353d-8ced-550f89677c37 _:Be103f316a34cef9bf45fbbcd6105d0ec|rdf:type|obo:NCIT_C53285 imgt:IgG1-nd_105|http://semanticscience.org/resource/SIO_000291|imgt:CD3E imgt:Segment_605_1|imgt:has_rank|1 imgt:Adagio_Therapeutics|rdfs:comment|Waltham , USA imgt:IgG1-lambda_955|obo:RO_0002162|imgt:Homsap imgt:scFv-heavy-kappa-CD8A_(CO-TM)-TNFRSF9_(CY)-CD247_1231|obo:RO_0002162|imgt:Chi imgt:Clone_1058|imgt:clone_name|737-H3 imgt:mAb_67|imgt:hasMabReceptor|imgt:IgG1-nd_67 imgt:TR-Beta-1-TRBC1|rdfs:label|TR-Beta-1-TRBC1 imgt:StudyProduct_3d6f46be-763a-3ce2-b8b0-cf79e8a37244|imgt:development_technology| Alternative to antigen receptors domain scaffold FN1 F10, fibronectin F10 (Adnectin™) imgt:MAbReceptor_994|http://semanticscience.org/resource/SIO_000291|imgt:bispecific imgt:11041|imgt:isImgtStructureEntryOf|imgt:mAb_678 imgt:mAb_634|imgt:inn_name|pegdinetanib obo:NCIT_C1909|rdf:type|owl:Class imgt:StudyProduct_34d69582-3597-3e4c-97ff-4e497863da54|rdfs:label|StudyProduct_34d69582-3597-3e4c-97ff-4e497863da54 imgt:Crohn's_disease_(CD)|imgt:isClinicalIndicationOf|imgt:StudyProduct_9a250394-ad13-3925-82cd-03f0b37210e6 imgt:FC-ALPHA|skos:definition|Fc comprising the CH2-CH3 domains from two H-ALPHA chains imgt:Merck_&_Co_Inc|imgt:produces|imgt:Product_b2cc8073-23cf-353d-8ced-550f89677c37 _:B1bf75098e709ec0814604a314a240213|imgt:isDecidedBy|imgt:FDA imgt:mAb_1210|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=1210 imgt:Alzheimer's_disease_(AD)|imgt:isClinicalIndicationOf|imgt:StudyProduct_02e6ed45-1e3c-3d4d-bdc7-e3ccfeb40215 imgt:mAb_623|imgt:inn_number|7559 imgt:IgG1-kappa_1188|imgt:isMabReceptorOf|imgt:mAb_1188 imgt:StudyProduct_0b83fc85-7c3f-32c6-bcac-bd3fabb42c9a|imgt:hasClinicalPhase|imgt:Phase_M imgt:StudyProduct_30a720ac-7d77-31fb-963e-7075ddafc936|rdf:type|obo:NCIT_C174271 imgt:Construct_1088|rdfs:label|Construct_1088 imgt:mAb_52|imgt:inn_proposed_list|89 (2003) imgt:StudyProduct_07dd16c8-3f11-3079-a7fb-eb7223ccb46a|rdfs:label|StudyProduct_07dd16c8-3f11-3079-a7fb-eb7223ccb46a imgt:Construct_430|rdf:type|imgt:Construct imgt:Product_0627b44a-53c2-39b9-93d4-afa1b06b8a7d|imgt:isProductOf|imgt:mAb_1230 _:Bf5cc05ac163cc093bb655d2065c1e6eb|imgt:hasStatut|imgt:approval imgt:StudyProduct_eba550c7-d4c5-3404-9bd1-41a9355ec09c|imgt:hasClinicalIndication|imgt:Asthma imgt:scFv-kappa-heavy-CD28_(CO-TM-CY)-CD247_1233|imgt:fused_with| CD28 (CO-TM-CY1) - CD247 (CY2) (1:1) imgt:FPIA_%5BPROTEIN%5D2-FC_1098|rdfs:label|FPIA_[PROTEIN]2-FC_1098 imgt:IgG1-kappa_428|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:mAb_1126|rdfs:label|mAb_1126 imgt:mAb_602|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=602 imgt:StudyProduct_48d24a9e-6ab2-3b26-9d02-7d4e0b7aae27|imgt:hasClinicalIndication|imgt:Polyarticular_Juvenile_Idiopathic_Arthritis_(PJIA) imgt:StudyProduct_8a9cd26d-f333-3b71-8411-80fdfab1538b|imgt:hasClinicalIndication|imgt:Cancers_non-small_cell_lung_(NSCLC) imgt:Construct_264|imgt:hasImgtLabel|imgt:CR1_(complement_receptor_type_1_C3b/C4b_receptor_C3BR_Knops_blood_group_KN_CD35)_41-238_peptidyl-myristoylated imgt:Product_6700b7b7-e2af-3ee8-873f-cb4f2bdca604|imgt:hasStudyProduct|imgt:StudyProduct_6b82f34f-3edd-3161-901d-a48e9eb3c856 imgt:IgG1-kappa_244|imgt:hasMolecularComponent|imgt:IG imgt:StudyProduct_ea328f38-4094-3173-9ba5-da13309befd0|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:Lombar_radicular_pain|imgt:isClinicalIndicationOf|imgt:StudyProduct_0f7e253b-e974-37b2-8035-41e3ff52d2a3 imgt:mAb_307|imgt:inn_name|nerelimomab imgt:brenzysmc|imgt:isBiosimilarOf|imgt:mAb_216 imgt:StudyProduct_3b92338f-1569-3227-9eea-a1f46a67f928|imgt:application_type|Therapeutic imgt:Construct_414|obo:BFO_0000051|imgt:Segment_414_1 imgt:%5BG1_VH-h-CH2-CH3%5D-dimer|rdfs:label|[G1 VH-h-CH2-CH3] - dimer imgt:StudyProduct_ba900ffd-ff21-33e4-bbef-8eaace304b8b|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_6d44a62a-2492-37df-91b3-c5ae1119d82d|rdf:type|obo:NCIT_C174271 imgt:MH1-Alpha-MH1-B|rdfs:label|MH1-Alpha-MH1-B imgt:IG-Light-Lambda-IGL|imgt:defines|imgt:IgG4_Lambda imgt:Product_29519aab-8c0a-3e53-8eea-8f07f4fc346a|imgt:commun_name|2130 imgt:mAb_370|rdf:type|obo:NCIT_C152144 imgt:StudyProduct_f5c1627a-5729-3447-8e2f-af98343675cf|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:StudyProduct_d3a265a6-bed9-31df-b3db-036c7062c581|imgt:hasClinicalIndication|imgt:Colitis_ulcerative_(UC) imgt:IgG1-kappa_875|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:Segment_478_1|imgt:has_rank|1 imgt:StudyProduct_312f2ba0-98d0-32ad-a11c-c2802aa7e886|imgt:application_type|Therapeutic imgt:mAb_645|imgt:inn_name|depatuxizumab mafodotin imgt:Solid_tumors|imgt:isClinicalIndicationOf|imgt:StudyProduct_4d43e64a-9282-3b26-a0c8-01df3b1cc94e imgt:StudyProduct_a0bc5cc3-9eda-3644-adfa-07762eeb3259|imgt:hasDecision|_:B02ce6bcbe50f8087e67877a80b0c4ef8 imgt:StudyProduct_d9a56cdb-aa81-30ba-9e20-78c4bd03b8f4|imgt:hasClinicalIndication|imgt:Platelet_aggregation imgt:CD3E|imgt:isTargetOf|imgt:scFv-TR_798 imgt:9916|rdfs:label|9916 imgt:IgG1-kappa_53|rdfs:comment|IgG1 - kappa imgt:IG-GAMMA-2A_KAPPA|rdfs:label|IG-GAMMA-2A_KAPPA imgt:half-G1-kappa_scFv-HEAVY-LAMBDA-h-CH2-CH3_919|rdf:type|imgt:MAbReceptor imgt:StudyProduct_2b5823b9-ed23-3d5a-b882-138c8f1a4919|imgt:hasClinicalPhase|imgt:Phase_III _:B4d293e23829a78581440e9691a39cfa2|imgt:hasStatut|imgt:approval obo:NCIT_C166988|rdfs:subClassOf|obo:NCIT_C1909 imgt:mAb_1194|imgt:hasMabReceptor|imgt:IgG1-kappa_1194 imgt:Product_ed1b4d51-6349-3a0c-b888-039ed6131076|imgt:comercial_name|PEGASYS® 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imgt:StudyProduct_30f1e3f7-8634-3b1c-b40a-0a2722a5b718|imgt:hasClinicalIndication|imgt:Systemic_lupus_erythematosus_(SLE) imgt:Construct_385|rdfs:label|Construct_385 imgt:StudyProduct_87e2c5f1-33e0-38ab-a626-e465e699fb62|rdfs:label|StudyProduct_87e2c5f1-33e0-38ab-a626-e465e699fb62 imgt:1V-1C-LIKE_1V-1C-LIKE_1V-1C-LIKE_1V-1C-LIKE|rdfs:label|1V-1C-LIKE_1V-1C-LIKE_1V-1C-LIKE_1V-1C-LIKE imgt:F(AB%27)2-GAMMA-1_LAMBDA|rdf:type|imgt:IGProteolyticFragmentLabel imgt:CO-TM-CY-REGION|rdfs:label|CO-TM-CY-REGION imgt:mAb_1211|imgt:inn_recommended_list|87 (2022) imgt:Product_95d79f23-a097-3b08-b973-202da2206ead|imgt:isProductOf|imgt:mAb_609 imgt:_CHO-S_(Chinese_Hamster_Ovary)_cells_suspension_culture|imgt:isExpressionSystemOf|imgt:StudyProduct_0f8fede9-ec3e-312e-b988-8fd26a9c1fd3 imgt:Product_33e35737-1cde-3654-a2bb-0b350fcde7dd|imgt:hasStudyProduct|imgt:StudyProduct_4972e244-5332-31b8-9bf1-291732bf097a imgt:StudyProduct_3b28e052-b149-35bf-89f9-79a5d320a5e5|imgt:application_type|Therapeutic _:B3c1958fc4a6f8a9f8efba526284fa798|imgt:isDecisionOf|imgt:StudyProduct_2ecb4a3d-036e-38d3-90fd-b81e950654d9 imgt:Menarini|rdf:type|obo:NCIT_C54131 imgt:mAb_963|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=963 imgt:mAb_63|imgt:imgt_note| Millennium Pharmaceuticals, Inc. is a subsidiary of Takeda Pharmaceuticals On November 26, 2001, XOMA Ltd. has entered into a development and license agreement with Millennium Pharmaceuticals, Inc. On October 10, 2003, XOMA Corporation announced that it discontinued development of bMLNM2201/b (formerly known as LDP-01). imgt:10242|rdfs:label|10242 imgt:Diabetic_macular_edema|imgt:clinical_domain|Immunology imgt:StudyProduct_93690cfa-8843-311b-b448-34d90b6bce53|rdfs:label|StudyProduct_93690cfa-8843-311b-b448-34d90b6bce53 imgt:IgG1-kappa-1cys_N84.4-drug_1072|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa-1cys%20N84.4-drug.png imgt:Segment_810_1|obo:BFO_0000050|imgt:Construct_810 imgt:Celimmune_LLC|imgt:produces|imgt:Product_6521ccf6-a005-3cb9-9946-f492ecfeb639 imgt:StudyProduct_c175e745-f820-3535-a583-cecc65a29f5f|imgt:application_type|Therapeutic imgt:StudyProduct_e95d8172-69b4-3985-b651-5cb4d80572eb|imgt:application_type|Therapeutic imgt:G-BETA|skos:definition|G-DOMAIN corresponding to domain 1 of a II-BETA chain imgt:mAb_352|rdfs:label|mAb_352 imgt:Segment_1013_1|rdf:type|imgt:Segment imgt:Product_6fc221fc-63c6-300f-8844-5210f60014c6|imgt:commun_name|CR011-vcMMAE imgt:Construct_1171|imgt:isConstructOf|imgt:IgG1-kappa_1171 imgt:Product_b9a738f9-5b22-38f9-848f-e3ea2ee2b97d|imgt:commun_name|AMG-557 imgt:StudyProduct_1139de5f-d2df-3035-acd7-dd41b73b2066|imgt:hasClinicalIndication|imgt:Type_2_diabetes_(T2_DM) imgt:Asthma|imgt:isClinicalIndicationOf|imgt:StudyProduct_e5a92120-d34e-313b-95dd-c562cdf5ef48 imgt:Segment_175_1|imgt:has_rank|1 _:Be8609c0bb01dc216461dab4f11d5ffbc|dc:date|2019-03-26 imgt:mAb_1156|imgt:hasImgtStructureEntry|imgt:11532 imgt:Construct_525|imgt:isConstructOf|imgt:TOXIN_BIG-PEPTIDE_525 imgt:IgG1-kappa_92|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:IgG4-kappa_942|http://semanticscience.org/resource/SIO_000291|imgt:CSF1R imgt:StudyProduct_fe591842-dbfe-3284-8445-d48f890b408d|imgt:application_type|Therapeutic imgt:Construct_1291|imgt:hasImgtLabel|imgt:LCN1_(lipocalin_1)_fragment_(1-154) imgt:Construct_1|rdf:type|imgt:Construct imgt:Product_70155ee2-7c09-3b5e-bdb9-23c93a11c339|imgt:isProducedBy|imgt:Eli_Lilly imgt:ANX2_(Pr88-159)|rdfs:label|ANX2 (Pr88-159) imgt:mAb_961|imgt:inn_proposed_list|121 (2019) imgt:StudyProduct_84943707-93aa-3f08-8787-9270eb6f179d|imgt:hasClinicalIndication|imgt:Anti-platelet_prevention_of_blood_clots_in_the_setting_of_high_risk_percutaneous_transluminal_coronary_angioplasty _:B3ad245da092ae7853062d492c8de3068|imgt:isDecidedBy|imgt:FDA imgt:StudyProduct_1354ecba-d4cb-3ad5-88b7-04667b5f8ae4|imgt:hasClinicalPhase|imgt:Phase_M imgt:FAB-ALPHA-1_LAMBDA|imgt:describes|imgt:Fab-Alpha-1_Lambda imgt:CD274|imgt:isTargetOf|imgt:IgG1-kappa_1239 imgt:Construct_559|rdf:type|imgt:Construct imgt:StudyProduct_c79acac8-704a-38ac-87bf-2ccb50abfbc7|imgt:hasClinicalPhase|imgt:Phase_II imgt:StudyProduct_7314f845-4d5f-37ea-82dd-ea3d9b47c86a|imgt:hasDecision|_:B39db33206a82aa968e5fec10cac57696 imgt:Construct_1199|obo:BFO_0000051|imgt:Segment_1199_1 imgt:10364|imgt:isImgtStructureEntryOf|imgt:mAb_652 _:Bc53b053059021b3255f4a85544210a15|imgt:isDecisionOf|imgt:StudyProduct_eb9774c4-d43d-34a3-b2d3-648900ef501c pubmed:9207350|imgt:isBibliographicReferenceOf|imgt:mAb_47 imgt:IgG1-kappa_327|rdfs:comment|IgG1 - kappa imgt:Cancers_small_cell_lung_(SCLC)|imgt:clinical_domain|Oncology imgt:G-ALPHA1-LIKE|rdfs:label|G-ALPHA1-LIKE imgt:mAb_139|imgt:inn_proposed_list|75 (1996) imgt:Construct_128|imgt:isConstructOf|imgt:F(ab%27)2-G3-kappa_128 imgt:Product_537aaf49-2c7a-3981-8bd7-5b72ab2e0fb9|imgt:commun_name|ACE910 imgt:Product_f272da3d-d319-39ce-a72e-2eaf8b604878|imgt:comercial_name|CIMZIA® _:B495799ec47f0d9b932e9eb7ceecbd6d7|rdf:type|obo:NCIT_C53285 imgt:Segment_545_1|rdf:type|imgt:Segment imgt:peptidyl-myristoylated|rdf:type|imgt:SegmentLabels imgt:Dermatological_genetic_disorders|imgt:isClinicalIndicationOf|imgt:StudyProduct_fba7e79d-561e-3e96-9eaa-d950e6bc0880 imgt:IgG1-kappa-4lys-drug_600|rdfs:comment|IgG1 - kappa - 4lys - drug imgt:Segment_176_1|rdfs:label|Segment_176_1 imgt:Product_e69abcdb-3e37-3bed-a630-2ae4ee615e7a|rdf:type|obo:NCIT_C51980 imgt:Product_01c1772e-8943-3b54-b0fe-518a65f83c6d|rdfs:label|Product_01c1772e-8943-3b54-b0fe-518a65f83c6d imgt:IgG1-kappa_728|http://semanticscience.org/resource/SIO_000291|imgt:Zaire_Ebola_virus imgt:StudyProduct_1bffc5d9-6be7-3f6f-aec0-82c150cfc547|imgt:application_type|Therapeutic imgt:Product_d2501478-25a5-378b-ae83-ee188222f233|rdfs:label|Product_d2501478-25a5-378b-ae83-ee188222f233 imgt:VH-V-kappa-CH2-CH3_488|imgt:hasMolecularComponent|imgt:IG imgt:BETA-ALPHA1_1041|rdfs:label|BETA-ALPHA1_1041 imgt:mAb_87|imgt:clinical_trials|72 studies found, 21 recruiting imgt:Segment_1294_2|imgt:has_rank|2 imgt:mAb_342|rdfs:label|mAb_342 imgt:Construct_386|rdf:type|imgt:Construct imgt:Cancers_non-small_cell_lung_(NSCLC)|imgt:isClinicalIndicationOf|imgt:StudyProduct_9dd722a9-f19d-3988-931a-95088159b79b imgt:mAb_892|rdfs:label|mAb_892 _:B5def1e133dca274003189f38913a4003|imgt:hasDesignation|imgt:Orphan_drug imgt:Product_ccfd4bb7-d8bd-302b-8b17-e3329a65fcc8|imgt:isProducedBy|imgt:Abbott_Laboratories imgt:Segment_141_1|obo:BFO_0000050|imgt:Construct_141 imgt:IgG2-kappa_469|imgt:hasConstruct|imgt:Construct_469 imgt:Construct_676|rdf:type|imgt:Construct imgt:Product_6070f2ac-d903-337d-beab-a7ca53d7c933|imgt:isProductOf|imgt:mAb_531 imgt:IgG1-kappa_716|imgt:hasConstruct|imgt:Construct_716 imgt:Segment_702_2|rdfs:label|Segment_702_2 imgt:Product_6e1baba0-c505-3188-a51c-ceefb62a6841|imgt:isProductOf|imgt:mAb_465 _:B007c49514bc2a0dfaa3a8b6009e99aee|imgt:isDecisionOf|imgt:StudyProduct_07c0e9b8-92c6-3c90-8d18-9f8cad364ddf imgt:Product_67bd7f52-411a-3222-8c8e-7f9687f922eb|imgt:hasStudyProduct|imgt:StudyProduct_88b7f4da-6add-3303-94de-de5618010eff imgt:mAb_1138|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=1138 imgt:Construct_592|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:IgG1-kappa_789|imgt:hasConstruct|imgt:Construct_789 imgt:mAb_1070|imgt:hasMabReceptor|imgt:IgG1-kappa_1070 imgt:mAb_640|imgt:inn_number|10506 imgt:IgG1-kappa_726|imgt:isMabReceptorOf|imgt:mAb_726 imgt:mAb_734|imgt:hasMabReceptor|imgt:VH_734 imgt:IgG1-kappa_1090|rdf:type|imgt:MAbReceptor imgt:StudyProduct_5e68f673-771d-3e00-9436-90e16636d1fc|rdfs:label|StudyProduct_5e68f673-771d-3e00-9436-90e16636d1fc imgt:OncoMed_Pharmaceuticals|imgt:produces|imgt:Product_5fd4206e-e7a6-3a22-81dc-b206288ecfd0 imgt:IgG1-kappa_662|imgt:isMabReceptorOf|imgt:mAb_662 imgt:IgG1-kappa_1205|imgt:isMabReceptorOf|imgt:mAb_1205 imgt:StudyProduct_93df20bb-0444-3290-9ab8-552809ed8377|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_5cd87dea-34f0-34e4-97ea-af0982f08b31|imgt:development_technology| MorphoSys's HuCAL® phage library imgt:StudyProduct_419a4556-e132-397a-82cb-9be68da5963f|rdf:type|obo:NCIT_C174271 imgt:J-C-gene|imgt:hasConfigurationType|imgt:G imgt:mAb_1200|rdf:type|obo:NCIT_C1909 imgt:Bayer_HealthCare_Pharmaceuticals|imgt:produces|imgt:Product_c5ff1e2f-3b88-3253-8ff2-5532b29230b5 imgt:mAb_414|rdfs:label|mAb_414 imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_5efd2628-c782-3cf8-876a-098e307d4872 imgt:mAb_861|imgt:hasMabReceptor|imgt:IgG1-kappa_861 imgt:StudyProduct_dece01d9-67ae-3cd7-8c6c-b0a053d1f3e8|imgt:hasClinicalIndication|imgt:Multiple_sclerosis_(MS) imgt:StudyProduct_179a071a-9734-3c09-ad67-168cf4dae0a3|imgt:hasDecision|_:B4f1c0d53d7a69f3cfdd64d7782eb25f0 imgt:mAb_873|imgt:hasProduct|imgt:Product_bf36bb4c-9e86-3e4c-8ddd-abcb09aaf3de imgt:mAb_957|rdf:type|imgt:INN obo:SO_0000566|rdf:type|owl:Class imgt:StudyProduct_cce1cf27-9062-3c21-b311-6b2c23f33ced|rdf:type|obo:NCIT_C174271 imgt:Avalo_Therapeutics|imgt:produces|imgt:Product_39d48962-4573-35af-8a7f-f05aac577f27 imgt:Product_dae89c23-6538-30bc-b71e-a66029df4793|imgt:commun_name|3G3 imgt:Construct_1028|obo:BFO_0000051|imgt:Segment_1028_1 imgt:IgG1-kappa_330|rdfs:comment|IgG1 - kappa _:B19308e745c727c2a5c5ed697ea39268c|dc:date|2014-11-25 obo:NCIT_C90875|rdfs:subClassOf|obo:NCIT_C1909 imgt:Product_8b707060-aa4c-3416-b720-0b2304c54b88|imgt:isProductOf|imgt:mAb_528 imgt:9762|imgt:isImgtStructureEntryOf|imgt:mAb_467 imgt:CXCL10|rdf:type|obo:NCIT_C25702 imgt:Product_56f1d246-c576-3e7e-a937-8f3bc41ecd9e|imgt:commun_name|IMGN853 imgt:IgG1-kappa_501|imgt:hasConstruct|imgt:Construct_501 imgt:Construct_758|obo:BFO_0000051|imgt:Segment_758_1 imgt:Segment_20_1|obo:BFO_0000050|imgt:Construct_20 imgt:IgG1-lambda_290|imgt:hasConstruct|imgt:Construct_290 imgt:IgG1-kappa_352|http://semanticscience.org/resource/SIO_000291|imgt:PDGFRA imgt:Product_73c81dcd-fbbc-38ac-a403-d4b47378e287|rdfs:label|Product_73c81dcd-fbbc-38ac-a403-d4b47378e287 imgt:(scFv-kappa-heavy)-(scFv-heavy-kappa)_405|http://semanticscience.org/resource/SIO_000291|imgt:CD3E imgt:MH1-ALPHA_B2M|imgt:describes|imgt:MH1 imgt:Construct_682|rdfs:label|Construct_682 imgt:Clone_34|rdfs:label|Clone_34 imgt:IgG1-kappa_812|http://semanticscience.org/resource/SIO_000291|imgt:bispecific imgt:Clone_549|imgt:clone_name|14B7 (scFv) imgt:Product_c5742b05-8a72-38fc-bf73-d7469ee38fbf|rdf:type|obo:NCIT_C51980 imgt:Product_e40335c6-1d9d-3d4d-b9fe-75c1775c1450|imgt:commun_name|SEG101 imgt:mAb_1190|imgt:inn_recommended_list|87 (2022) imgt:Clone_119|rdf:type|obo:NCIT_C37925 _:Bc87ceeadf9bef2a3542fef7f94fb8d4d|imgt:isDecisionOf|imgt:StudyProduct_71208dab-9f1e-3a59-b5e7-e15f341ef594 imgt:StudyProduct_bcd14e53-bdb2-3301-8a94-47c1c744e4a4|imgt:isStudyProductOf|imgt:Product_4391f6b4-98b1-38e2-94d2-967326f820fe imgt:Segment_920_1|obo:BFO_0000050|imgt:Construct_920 imgt:StudyProduct_c933dab2-441a-3c14-b9e9-3453cb22aff9|imgt:hasClinicalPhase|imgt:Phase_II imgt:Construct_800|imgt:isConstructOf|imgt:IgG1-lambda_800 imgt:Segment_214_1|imgt:has_rank|1 imgt:mAb_1217|imgt:hasOriginClone|imgt:Clone_1217 imgt:IgG4-lambda_894|rdfs:comment|IgG4 - lambda imgt:D-J-SEQUENCE|rdf:type|imgt:PrototypeLabel imgt:FUSION-SELPG-GAMMA-1|skos:definition|SELPG fused with G1 H-CH2-CH3 imgt:SLC3A2|rdfs:label|SLC3A2 imgt:StudyProduct_c32ff34d-399e-3f3d-8ee3-8e8c565ef2cf|imgt:application_type|Therapeutic imgt:Asthma|imgt:isClinicalIndicationOf|imgt:StudyProduct_3368c03f-aa59-37c6-982b-b1971a1c3a45 obo:SO_0000340|rdfs:comment|This term is mapped to MGED. Do not obsolete without consulting MGED ontology. imgt:Clone_567|obo:RO_0002162|imgt:Musmus imgt:StudyProduct_f9196c0c-e1e8-3750-af80-9d7065d93b5f|imgt:development_technology| Abgenix's XenoMouse® imgt:IgG1-kappa-4cys-drug_784|obo:RO_0002162|imgt:Hum imgt:CPCA_three-helical_bundle_1046|imgt:hasMolecularComponent|imgt:CPCA imgt:NGR_peptide|rdf:type|imgt:SegmentLabels imgt:IgG4-kappa_44|imgt:conjugated_with| N-acetyl-gamma calicheamicin imgt:Segment_1008_1|imgt:has_rank|1 imgt:Vectura_Group_Plc|imgt:produces|imgt:Product_9644c27e-d6e1-34ac-b2e2-7fc4cdf6bc66 imgt:mAb_316|imgt:inn_number|7227 imgt:Product_a40b72fa-6beb-3dea-9182-268887df521d|imgt:hasStudyProduct|imgt:StudyProduct_82596810-73a4-3823-92ab-f261c6581d9e imgt:Product_8aa4e449-9a5b-35c3-808a-3f569719efe1|rdf:type|obo:NCIT_C51980 imgt:mAb_942|rdfs:label|mAb_942 imgt:mAb_722|imgt:inn_recommended_list|78 (2017) imgt:StudyProduct_c9cc9b8f-768e-34d7-8f47-1cb65379c659|rdfs:label|StudyProduct_c9cc9b8f-768e-34d7-8f47-1cb65379c659 imgt:mAb_775|rdfs:label|mAb_775 imgt:Segment_584_1|rdfs:label|Segment_584_1 imgt:mAb_702|rdfs:label|mAb_702 imgt:heat_shock_protein_90_homolog|rdf:type|obo:NCIT_C25702 imgt:Product_3d70c6f7-d58f-3dbd-b8a0-06517209c35b|imgt:commun_name|HuMax-CD38 imgt:mAb_921|imgt:hasMabReceptor|imgt:half-G1-kappa_scFv-HEAVY-LAMBDA-h-CH2-CH3_921 imgt:Segment_1062_1|rdf:type|imgt:Segment imgt:Product_ed4d7050-ec06-3d8f-ad79-430d7ecba4ec|imgt:isProductOf|imgt:mAb_35 imgt:Clone_39|rdf:type|obo:NCIT_C37925 imgt:germline|dc:identifier|imgt_000003 imgt:Johnson_&_Johnson|rdfs:label|Johnson & Johnson pubmed:7682986|dc:date|1993 imgt:StudyProduct_84a42155-6dd6-3495-a524-9129094cea33|imgt:isStudyProductOf|imgt:Product_95d79f23-a097-3b08-b973-202da2206ead imgt:Segment_247_1|imgt:has_rank|1 imgt:University_Bath|rdfs:comment|Bath , UK imgt:Product_188975ba-e8fc-3ccd-8368-e47522abda48|rdfs:label|Product_188975ba-e8fc-3ccd-8368-e47522abda48 imgt:CSF3|rdf:type|imgt:SegmentLabels _:B1948feff9ddbdce1cf5eaa943c65d1cd|imgt:hasStatut|imgt:approval imgt:mAb_374|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=374 http://semanticscience.org/resource/SIO_000291|skos:definition|has target is a relation between a process and an entity, where the entity is present at the beginning of the process and undergoes a change or transformation in the process. imgt:PROTEIN_1DOMAIN-PEG_630|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/PROTEIN_1DOMAIN-PEG.png imgt:CRP_(Pr19-224)|skos:definition|C-reactive protein imgt:StudyProduct_2ee66cc6-fdb3-35fc-9720-fb204acaf58b|imgt:application_type|Therapeutic imgt:10315|rdf:type|obo:NCIT_C25402 imgt:Segment_413_3|rdfs:label|Segment_413_3 imgt:Product_46ba9f2a-6976-370b-8353-203ec4474217|imgt:hasStudyProduct|imgt:StudyProduct_46ba9f2a-6976-370b-8353-203ec4474217 imgt:Genentech_Inc|imgt:produces|imgt:Product_56e1aba5-d1fa-3556-89ad-76c1dd577359 imgt:mAb_771|rdfs:label|mAb_771 imgt:Segment_697_2|rdfs:label|Segment_697_2 _:B994e98b28d16c39ba2a9cd9e9bbb1f9e|imgt:isDecidedBy|imgt:FDA imgt:mAb_679|imgt:hasImgtStructureEntry|imgt:10569 imgt:mAb_162|imgt:inn_number|9153 imgt:9610|rdf:type|obo:NCIT_C25402 imgt:mAb_228|imgt:hasOriginClone|imgt:Clone_228 imgt:Product_d897727a-4fb2-3eb1-99b5-48e3b1af7b74|imgt:isProducedBy|imgt:Atridia_Pty_Ltd imgt:IgG1-nd_MM_309|imgt:hasConstruct|imgt:Construct_309 imgt:Glycotope_GmbH|rdfs:comment|Berlin , Germany imgt:mAb_981|rdf:type|imgt:INN imgt:StudyProduct_9b9bf253-4abd-3586-adc0-258764ae7a38|imgt:application_type|Therapeutic imgt:Mus_musculus|imgt:hasTaxonRank|species imgt:8716|imgt:isImgtStructureEntryOf|imgt:mAb_248 imgt:IgG1-kappa_589|http://semanticscience.org/resource/SIO_000291|imgt:IL2RA imgt:Segment_860_1|obo:BFO_0000050|imgt:Construct_860 imgt:Disease-Modifying_Anti-Rheumatic_Drug_(DMARD)|imgt:isClinicalIndicationOf|imgt:StudyProduct_8870f440-5d37-3ef9-bb0e-3c00ea5d4b1a imgt:SORT1|rdf:type|obo:NCIT_C25702 imgt:StudyProduct_beb58537-8503-3cb1-a6b2-0deccc1df0f7|rdf:type|obo:NCIT_C174271 imgt:Charing_Cross_Sunley_Research_Centre|rdfs:label|Charing Cross Sunley Research Centre imgt:Cancers_breast|imgt:isClinicalIndicationOf|imgt:StudyProduct_a97a8d93-fa7e-3f39-ba19-1929fe3fab4c imgt:StudyProduct_bab1fcdb-ee9a-3e26-8464-ed03017f717c|rdfs:label|StudyProduct_bab1fcdb-ee9a-3e26-8464-ed03017f717c imgt:Segment_248_1|imgt:hasImgtLabel|imgt:IgG2-kappa obo:NCIT_C116788|rdf:type|owl:Class imgt:11465|rdf:type|obo:NCIT_C25402 imgt:Segment_743_1|obo:BFO_0000050|imgt:Construct_743 imgt:StudyProduct_b763567d-d8b5-328e-af03-9fdceeaf948c|imgt:hasClinicalPhase|imgt:Phase_II imgt:StudyProduct_cbe90bfe-6f84-3a8b-9143-95c5b5332204|imgt:hasClinicalPhase|imgt:Phase_II imgt:StudyProduct_aaf066df-3656-3025-80a3-0e31ed88ed73|rdfs:label|StudyProduct_aaf066df-3656-3025-80a3-0e31ed88ed73 imgt:StudyProduct_d32090e7-fae7-3e87-9f1f-01cdccb6a415|rdf:type|obo:NCIT_C174271 imgt:mAb_1289|imgt:inn_number|12056 imgt:bispecific|imgt:isTargetOf|imgt:CPCA_three-helical_bundle_1053 _:B6a407e496338df091af9dc7952bf9587|imgt:isDecidedBy|imgt:FDA imgt:Product_be140b70-fccf-3adc-ab0e-066855350e81|imgt:commun_name|REGN-2810 imgt:FN1-7|skos:definition|Fibronectin I imgt:IL23A|rdf:type|obo:NCIT_C25702 imgt:Product_1f73dd63-2db7-39af-95ec-0844134e2f55|imgt:commun_name|MEDI-563 _:B02c0079b832202ec4a2686413895f784|rdf:type|obo:NCIT_C53285 imgt:mAb_163|rdf:type|obo:NCIT_C1909 imgt:StudyProduct_307891eb-1992-3650-8ae5-9901a09d01f3|imgt:application_type|Therapeutic _:B44563f1afb4b72bd04bf10fbbc75de90|imgt:hasStatut|imgt:approval imgt:Product_b53d5313-835d-3d6b-8fb3-a4650e3a36ef|imgt:commun_name|BMS-986414 imgt:mAb_818|imgt:inn_name|tengonermin imgt:Cancers_gastrointestinal|rdfs:label|Cancers_gastrointestinal imgt:Product_e5ca6245-7a11-3390-b7de-6b5e8870b2ab|rdf:type|obo:NCIT_C51980 imgt:mAb_737|rdf:type|obo:NCIT_C152295 imgt:Segment_1218_1|imgt:has_rank|1 imgt:influenza_A_virus_hemagglutinin_HA2_subunit_from_various_strains|imgt:isTargetOf|imgt:IgG1-lambda_494 imgt:DKK1|obo:RO_0002162|imgt:Homsap imgt:mAb_1077|imgt:hasMabReceptor|imgt:IgG4-kappa_1077 imgt:StudyProduct_71b76561-5af2-36de-aff5-e5a2a90b6dc2|imgt:hasClinicalPhase|imgt:Phase_II imgt:Fab%27-G2a-kappa_306|rdfs:comment|Fab' - G2a - kappa imgt:IG-GAMMA-4_KAPPA|rdf:type|imgt:IGCompleteReceptorLabel imgt:mAb_1147|rdfs:label|mAb_1147 imgt:Segment_149_1|rdfs:label|Segment_149_1 imgt:Neoplasms|imgt:isClinicalIndicationOf|imgt:StudyProduct_d74913bc-d211-3fa5-aefe-309ead7232fe imgt:Product_c25395cf-d8e1-3156-8672-bccded639c93|imgt:comercial_name|TEPEZZA® imgt:%5BPEPTIDE-PEPTIDE%5D2-FC_413|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/[PEPTIDE-PEPTIDE]2-FC.png imgt:Sinocelltech_Ltd|imgt:produces|imgt:Product_161f8d36-1cee-338d-88ce-55a0108d54a3 imgt:Product_de6b73a9-944b-34bc-ad4c-f6cbd43ea96a|imgt:hasStudyProduct|imgt:StudyProduct_883c0f9e-446e-3d08-b9da-eec6c9736e2a imgt:Product_5ce3b46d-9c42-34a1-a25d-2571a2d48a7a|imgt:commun_name|RO7092284 imgt:StudyProduct_04a588ca-f4e9-3453-8e00-e517064379bc|imgt:hasDecision|_:B6a407e496338df091af9dc7952bf9587 imgt:Hepatitis_C_reinfection_in_liver_transplant_patients|imgt:isClinicalIndicationOf|imgt:StudyProduct_7e747b42-756f-362e-bf69-d6b3856a8ba4 imgt:IgG1-lambda_1247|imgt:hasMolecularComponent|imgt:IG imgt:Product_62e555bc-de18-34ed-b8f6-f3695acdd1ce|imgt:commun_name|AGS-22M imgt:IgG1-kappa-4cys-drug_457|rdfs:comment|IgG1 - kappa - 4cys - drug imgt:mAb_713|rdfs:label|mAb_713 imgt:StudyProduct_9d015d25-8b54-37e3-8277-0e255536760d|rdfs:label|StudyProduct_9d015d25-8b54-37e3-8277-0e255536760d imgt:PDGFRB|imgt:isTargetOf|imgt:IgG4-kappa_574 imgt:Construct_923|imgt:isConstructOf|imgt:IgG4-kappa_923 imgt:D-transcript|skos:definition|Identifies for mRNA molecule entities with a germline D region. D-transcript is in germline configuration. imgt:10695|rdfs:label|10695 imgt:Product_5837df28-0765-30d4-b29a-8af0402307e7|imgt:commun_name|MEDI-493 imgt:StudyProduct_937a3a90-3cba-3068-967b-7d14a1c3ac4e|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:StudyProduct_f2fdd327-9ce0-3b8a-a003-26d99efcb324|imgt:hasClinicalPhase|imgt:Phase_I/II imgt:IgG1-kappa_1141|rdfs:comment|IgG1 - kappa imgt:CAAT_SIGNAL|rdf:type|imgt:RegulationLabel imgt:StudyProduct_f7ad8347-265c-3167-afae-3618b62d9db2|imgt:hasClinicalPhase|imgt:Phase_I/II imgt:Roche_F_Hoffmann-La_Roche_Ltd|imgt:produces|imgt:Product_4ecbc6e7-591c-327e-83d0-e2f2e4a2a07d imgt:_Sp2/0_mouse_hybridoma_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_0d0b843e-ae7e-3ec1-8787-5451392da30d imgt:StudyProduct_736ffcc6-721d-3db7-8722-277cad27116a|imgt:application_type|Therapeutic imgt:IgG1-nd_184|imgt:isMabReceptorOf|imgt:mAb_184 imgt:mAb_755|imgt:hasImgtStructureEntry|imgt:10468 imgt:mAb_926|imgt:inn_name|inbakicept imgt:chimeric|rdfs:comment| or synthetic) linked to a constant region (C-REGION) of human origin. imgt:IgG1-kappa_803|obo:RO_0002162|imgt:Hum imgt:Facioscapulohumeral_muscular_dystrophy_(FSHMD)|imgt:isClinicalIndicationOf|imgt:StudyProduct_95f2348f-0d7e-3304-99e9-a1649fc0abe7 imgt:StudyProduct_28be0a14-2fba-3773-b625-52940c25b0b8|rdfs:label|StudyProduct_28be0a14-2fba-3773-b625-52940c25b0b8 imgt:mAb_1203|rdfs:label|mAb_1203 imgt:IgG1-V-lambda-C-kappa_856|imgt:isMabReceptorOf|imgt:mAb_856 imgt:StudyProduct_801c8339-57b5-3f8c-8836-5923647a48db|rdf:type|obo:NCIT_C174271 imgt:Product_7f541229-0da9-394f-9b52-75a178aece02|imgt:hasStudyProduct|imgt:StudyProduct_fe029148-b943-335c-8af0-e7fe24d86ee1 _:Bce25bc9a87435ede4610d7dab9305954|imgt:isDecidedBy|imgt:FDA imgt:TR-GAMMA-1_DELTA|rdf:type|imgt:TRCompleteReceptorLabel imgt:Product_f4aba402-2987-38e9-bc54-e9bacc917b27|imgt:isProductOf|imgt:mAb_873 obo:NCIT_C175859|rdfs:subClassOf|obo:NCIT_C1909 imgt:Product_8b260346-f2ee-3675-b1d5-da4ddf2a1424|imgt:hasStudyProduct|imgt:StudyProduct_a63973cd-64cf-32f9-a550-7941312253c6 imgt:IgG3-kappa_507|rdf:type|imgt:MAbReceptor imgt:Hemophilia_B_(control_and_prevention_of_bleeding_episodes)|imgt:isClinicalIndicationOf|imgt:StudyProduct_6d2b9607-0f54-334f-9a71-2538aca2b433 imgt:Product_463a66bb-9d66-383f-941e-52398ad21a7e|imgt:isProductOf|imgt:mAb_48 imgt:IG-Light-Kappa-IGKC|imgt:defines|imgt:IgG2_Kappa imgt:StudyProduct_3675c576-0e95-3437-932b-db3c2cbab80a|imgt:hasClinicalIndication|imgt:Glioblastoma imgt:StudyProduct_a430c013-7bae-3edf-be77-5e1eed7daab0|imgt:hasClinicalIndication|imgt:Esophagitis_eosinophilic imgt:IgG2a-lambda|rdf:type|imgt:ConstructLabels imgt:StudyProduct_551f1aee-1dce-376f-91fe-32647bc613b2|imgt:hasClinicalIndication|imgt:Cancers_non-small_cell_lung_(NSCLC) imgt:Product_8ab7fc81-b8d6-308e-9064-5a153be43d1b|imgt:commun_name|AVB-500 imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_bf5eb408-cd4f-368d-9967-1230c1d1e925 imgt:mAb_500|rdfs:label|mAb_500 imgt:mAb_324|imgt:hasMabReceptor|imgt:IgG1-kappa-4cys-drug_324 imgt:scFv-h-CH2-CH3_1189|imgt:hasConstruct|imgt:Construct_1189 imgt:StudyProduct_cafca025-11b9-3ed9-ad0d-d2462100b330|imgt:hasClinicalPhase|imgt:Phase_III imgt:Organ_transplant_immunological_rejection_suppression|imgt:isClinicalIndicationOf|imgt:StudyProduct_02a5d74c-0f83-3ab4-bf1e-8261d9c461d3 imgt:StudyProduct_42e77b63-637a-3381-a8be-5f8318cc28a2|rdf:type|obo:NCIT_C174271 imgt:Segment_687_1|obo:BFO_0000050|imgt:Construct_687 imgt:Product_08bd6972-3307-3ac1-9be9-270ca2564841|imgt:commun_name|CTB 011 imgt:Segment_782_1|obo:BFO_0000050|imgt:Construct_782 imgt:mAb_865|imgt:inn_name|gancotamab imgt:mAb_1038|imgt:hasImgtStructureEntry|imgt:11304 _:Bea2e032286ea424e4be75b4a5490acb6|rdf:type|obo:NCIT_C53285 imgt:StudyProduct_0a7ee814-2505-3fad-b45d-eb973c69a29d|imgt:hasClinicalPhase|imgt:Phase_I imgt:IgG4-kappa_1034|rdf:type|imgt:MAbReceptor imgt:IgG2-lambda_492|obo:RO_0002162|imgt:Hum obo:NCIT_C184870|rdf:type|owl:Class imgt:StudyProduct_e74e6492-ccee-3cfe-984b-10204f242972|rdfs:label|StudyProduct_e74e6492-ccee-3cfe-984b-10204f242972 imgt:IgG4-lambda_829|imgt:hasMolecularComponent|imgt:IG imgt:IgG1-kappa_1213|rdf:type|imgt:MAbReceptor imgt:Segment_422_1|rdf:type|imgt:Segment imgt:Product_34d390d4-4caa-3b24-b9bd-975fca71bdeb|imgt:hasStudyProduct|imgt:StudyProduct_d1b96c28-9bae-370a-b995-677b4d8fa1f9 imgt:_GS-NS0|imgt:isExpressionSystemOf|imgt:StudyProduct_30bb3825-e8f6-31cc-a075-c0f87bb4978c imgt:Product_3b4f91a3-db33-3ada-ac7a-1fb78bd67464|imgt:commun_name|VIR-7831 imgt:StudyProduct_3449776c-d9a1-37be-b4e5-1aaf903cfe69|imgt:application_type|Therapeutic imgt:StudyProduct_0a85bc23-6d76-3b8d-9920-b9681958b75e|imgt:hasClinicalIndication|imgt:Lymphoma_B_cell imgt:mAb_609|imgt:hasProduct|imgt:Product_95d79f23-a097-3b08-b973-202da2206ead imgt:Construct_471|imgt:isConstructOf|imgt:IgG1-lambda-3lys-drug_471 _:Bafb0b015d0ec0e82b3a08dd76968924a|imgt:hasStatut|imgt:approval imgt:mAb_506|imgt:inn_recommended_list|73 (2015) imgt:Product_90f4823e-5cb9-333f-bd91-f83046626483|rdfs:label|Product_90f4823e-5cb9-333f-bd91-f83046626483 imgt:IgG1-kappa_965|http://semanticscience.org/resource/SIO_000291|imgt:bispecific imgt:mAb_351|imgt:inn_proposed_list|103 (2010) imgt:Product_c3e77c6d-5c6a-3f85-a3a3-d27127306a24|imgt:commun_name|ch14.18 imgt:IG-Heavy-Delta-IGHD|imgt:defines|imgt:IgD_Lambda imgt:IgG2-kappa_646|rdfs:label|IgG2-kappa_646 imgt:Product_5fc9aa53-f083-3789-8cf2-ea4a5852e7d2|imgt:commun_name|AC2993 imgt:_CHO_DG44_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_abc3c266-379b-3ea9-9dc9-1980481db404 imgt:Construct_791|rdf:type|imgt:Construct imgt:IgG1-kappa_298|rdf:type|imgt:MAbReceptor imgt:IgG1-kappa-%5BscFv%5D2-lambda_545|http://semanticscience.org/resource/SIO_000291|imgt:ERBB3 imgt:mAb_1250|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=1250 imgt:10750|imgt:isImgtStructureEntryOf|imgt:mAb_806 imgt:StudyProduct_337c97f1-fee5-35a1-a552-4d1e6dcc3d63|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:(DJ)-J-C-CLUSTER|owl:sameAs|obo:SO_0000540 imgt:IgG1-kappa_453|http://semanticscience.org/resource/SIO_000291|imgt:PDCD1 _:B44563f1afb4b72bd04bf10fbbc75de90|imgt:isDecidedBy|imgt:FDA imgt:Psoriasis|imgt:isClinicalIndicationOf|imgt:StudyProduct_32d71c60-6cad-3aec-9c1e-55745532353b imgt:IgG1-lambda_169|http://semanticscience.org/resource/SIO_000291|imgt:HBV imgt:Lees_Pharmaceutical|rdfs:label|Lee's Pharmaceutical imgt:Sorrento_Therapeutics_Inc|rdf:type|obo:NCIT_C54131 imgt:Rheumatoid_arthritis_(RA)|imgt:isClinicalIndicationOf|imgt:StudyProduct_8eac3427-fe5b-3005-a475-4555908e9884 _:Bc3ea9c123d427d84245148d9a6f47f7a|rdf:type|obo:NCIT_C53285 pubmed:19567914|rdfs:label|PMID_19567914 imgt:Segment_765_1|rdfs:label|Segment_765_1 imgt:StudyProduct_736ffcc6-721d-3db7-8722-277cad27116a|rdf:type|obo:NCIT_C174271 imgt:mAb_180|imgt:hasMabReceptor|imgt:IgG1-kappa_180 imgt:mAb_1140|imgt:inn_name|plonmarlimab imgt:Product_d3ad2e1c-9b13-330e-b304-44210fcef926|imgt:hasStudyProduct|imgt:StudyProduct_8b4d3596-2526-3728-ba89-3cb62915dde9 imgt:Construct_1097|rdfs:label|Construct_1097 imgt:mAb_573|imgt:hasProduct|imgt:Product_1aaa2a7e-6eb9-3729-a3c8-9ebd6913b871 imgt:StudyProduct_de186662-6f7a-30f2-9d80-3753d52df779|imgt:isStudyProductOf|imgt:Product_4bcf26da-1bfa-3adc-b672-ba6baebe9a8c imgt:mAb_101|imgt:hasProduct|imgt:Product_d5331edb-b52e-3dc3-99e7-61c04420b4bb imgt:StudyProduct_0e676733-e241-3eff-a6d5-e87e8b162340|imgt:isStudyProductOf|imgt:Product_4cc47359-f3f3-3da9-9e42-fd7f4c895ef3 imgt:Product_a906e8c2-5cd0-31d0-9f46-849a19d4b85b|rdfs:label|Product_a906e8c2-5cd0-31d0-9f46-849a19d4b85b imgt:StudyProduct_1488b958-4851-3c48-8fe8-dc236ea9ed0f|imgt:hasExpressionSystem|imgt:_E.coli_(Escherichia_coli) imgt:IgG1-kappa_11|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:11943|rdf:type|obo:NCIT_C25402 imgt:IgG4-kappa-4lys-drug_389|rdfs:comment|IgG4 - kappa - 4lys - drug imgt:MIF|obo:RO_0002162|imgt:Homsap imgt:Segment_417_1|rdf:type|imgt:Segment imgt:IL17A|imgt:isTargetOf|imgt:IgG4-kappa_1168 imgt:Fab%27-R-Fab%27_220|http://semanticscience.org/resource/SIO_000291|imgt:bispecific imgt:Segment_1045_1|rdfs:label|Segment_1045_1 imgt:Clone_1153|rdfs:label|Clone_1153 imgt:StudyProduct_f791dd12-d70e-318e-8882-69d14a827198|imgt:hasDecision|_:B55e7025d7bc807aa110512a4ea44fe81 imgt:Clone_295|obo:RO_0002162|imgt:Homsap imgt:mAb_493|rdfs:label|mAb_493 imgt:StudyProduct_7b3742d7-bcb4-3f36-a556-e5759a2f156f|imgt:application_type|Therapeutic _:B32f6ec0e3013939325b5a6b565de8aff|dc:date|2019-12-20 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(Wilson NC USA) approved in the EU by EC on June 15 2017. Same clinical indications as NEUPOGEN®. imgt:IgG1-kappa_232|rdfs:comment|IgG1 - kappa imgt:StudyProduct_44a6e267-869c-3dba-ba18-896dcd597661|rdf:type|obo:NCIT_C174271 imgt:mAb_1094|rdf:type|obo:NCIT_C175849 imgt:Segment_398_1|imgt:has_rank|1 imgt:11032|imgt:isImgtStructureEntryOf|imgt:mAb_927 imgt:IgG1-kappa_771|http://semanticscience.org/resource/SIO_000291|imgt:bispecific imgt:mAb_616|imgt:hasBiosimilar|imgt:nyvepria™ _:Bb0f6a8e3afe0de102db5d1244914a63a|imgt:isDecidedBy|imgt:FDA imgt:Construct_118|imgt:isConstructOf|imgt:IgM-nd_118 _:B4dc91c793c3122a1ef9631c78ce00e65|imgt:isDecidedBy|imgt:FDA imgt:Product_6be191cd-f8da-3267-8190-2deedbc9ec49|rdfs:label|Product_6be191cd-f8da-3267-8190-2deedbc9ec49 imgt:Product_dd7c53c2-e62e-38a6-89d3-770f9d73c78c|imgt:isProducedBy|imgt:Kenta_Biotech_Ltd imgt:9599|rdfs:label|9599 imgt:Product_7c5b4231-8351-3ed9-ba1d-8c48699ed506|rdf:type|obo:NCIT_C51980 obo:NCIT_C1321|rdfs:subClassOf|obo:NCIT_C1909 imgt:mAb_284|imgt:hasMabReceptor|imgt:PROTEIN_4REPEATS_284 imgt:_CHO_(Chinese_Hamster_Ovary)_dihydrofolate_reductase_(DHFR)-deficient_cells|rdf:type|imgt:ExpressionSystem imgt:StudyProduct_e1cc0bb3-b0d8-3317-a388-9ccd912321e0|rdf:type|obo:NCIT_C174271 _:B63c7d069b724fa5444696b20cdac46f4|imgt:isDecidedBy|imgt:EMA imgt:IgA1_Kappa|imgt:isDescribedBy|imgt:IG-ALPHA-1_KAPPA imgt:StudyProduct_1e2bc35b-44f3-3a3b-8938-77751325cdeb|imgt:hasClinicalPhase|imgt:Phase_II imgt:StudyProduct_1892f39a-7a9d-3365-8bf8-9fb65c8dc355|imgt:hasClinicalIndication|imgt:Chronic_lymphocytic_leukemia_(CLL) imgt:Product_110d7ea4-092e-3731-844f-8477a86a4636|imgt:isProductOf|imgt:mAb_1293 imgt:Product_f4aba402-2987-38e9-bc54-e9bacc917b27|imgt:commun_name|Autologous T cells transduced with C11D5.3 scFv-8A-F9Z CAR (C11D5.3 scFv-CD8A-TNFRSF9-CD247 (CD3Z), bb2121, bb-2121) imgt:Human_Genome_Sciences_Inc_(HGSI)|imgt:produces|imgt:Product_cd3c7721-1cc7-3d35-9b13-b8b3103fe71c imgt:Product_e74c938c-d5ce-32f7-80c4-b52d9dfc9789|imgt:isProducedBy|imgt:GlaxoSmithKline imgt:IgA-nd_121|obo:RO_0002162|imgt:Musmus imgt:12026|rdfs:label|12026 _:Be5c42d4a6078c77857e28758f69842c3|imgt:hasStatut|imgt:approval pubmed:12359774|dc:date|2002 imgt:StudyProduct_589b75c7-1ae4-35da-9033-6e3be2cba1a1|imgt:development_technology| Chimeric antigen receptor (CAR) T cell engineering imgt:VEGFA|imgt:isTargetOf|imgt:VH-C-kappa-CH2-CH3_V-lambda-CH1_H-GAMMA-1_L-kappa_500 imgt:StudyProduct_98584f2f-5e15-3079-9ad4-e8b06f7f8621|imgt:hasClinicalIndication|imgt:Allograft_rejection imgt:AVEO_Pharmaceuticals|imgt:produces|imgt:Product_68af66eb-bd12-306b-b51f-ad26587efd5b imgt:Segment_1058_1|rdfs:label|Segment_1058_1 imgt:Segment_1260_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Construct_789|rdf:type|imgt:Construct imgt:Clone_652|rdfs:label|Clone_652 imgt:mAb_467|imgt:inn_number|9762 imgt:Clone_1029|rdfs:label|Clone_1029 imgt:Catalyst_Biosciences_Inc|rdf:type|obo:NCIT_C54131 imgt:mAb_807|imgt:inn_recommended_list|80 (2018) imgt:StudyProduct_f3630f74-f953-395b-93d3-1119b53391a6|imgt:hasClinicalIndication|imgt:Graft-versus-host_disease_(GvHD) imgt:StudyProduct_521bdb6c-241f-3c8b-83bf-6f87a696275a|imgt:hasClinicalPhase|imgt:Phase_III imgt:mAb_276|rdfs:label|mAb_276 imgt:mAb_592|imgt:hasImgtStructureEntry|imgt:10187 imgt:StudyProduct_b063c60c-7c3d-3aac-92b4-c8661305b3be|rdf:type|obo:NCIT_C174271 imgt:mAb_857|imgt:inn_number|10779 imgt:Product_89f1ae82-3fb5-3b22-b31b-63474999c711|imgt:isProducedBy|imgt:Hanmi_Pharmaceutical imgt:Product_b5f95da1-0c01-3d38-90fc-3c3ed7a420c9|rdfs:label|Product_b5f95da1-0c01-3d38-90fc-3c3ed7a420c9 imgt:Product_dc5d0295-91f0-3aeb-9b3e-15ed4c4c9f19|rdfs:label|Product_dc5d0295-91f0-3aeb-9b3e-15ed4c4c9f19 imgt:StudyProduct_9937a441-0ec1-3a63-aad1-05d1c815f902|imgt:hasClinicalPhase|imgt:Phase_I/II imgt:StudyProduct_c6f931a0-8445-3775-825c-978cc46d6922|rdfs:label|StudyProduct_c6f931a0-8445-3775-825c-978cc46d6922 imgt:IgG2-kappa_972|rdfs:label|IgG2-kappa_972 imgt:Clone_259|imgt:clone_name|G544 _:B25cbfe1a6c0f1d4e0092355808805650|rdf:type|obo:NCIT_C53285 imgt:IgG1-nd_72|http://semanticscience.org/resource/SIO_000291|imgt:IL2RB imgt:Construct_679|imgt:hasImgtLabel|imgt:V-Lambda-VH_V-Kappa-VH%27 imgt:Fab-Mu_Lambda|rdf:type|imgt:ReceptorType imgt:StudyProduct_02e6ed45-1e3c-3d4d-bdc7-e3ccfeb40215|imgt:hasDecision|_:Bcccdec547856261b5180d293ed013ea3 imgt:StudyProduct_be2b31df-4db9-34e1-ada9-6ee302f6a3f7|imgt:hasClinicalPhase|imgt:Phase_III _:B40a26fc9be11b93e007b3160e27573ab|imgt:isDecisionOf|imgt:StudyProduct_d08a20b2-9c23-3e4f-a00b-6f83c51732a6 imgt:Segment_839_1|obo:BFO_0000050|imgt:Construct_839 imgt:StudyProduct_44a7f8b3-31ac-3651-9776-bce5a4dbd9a9|imgt:isStudyProductOf|imgt:Product_97eb3150-0428-3667-a1e0-19b78474365d imgt:Construct_457|imgt:isConstructOf|imgt:IgG1-kappa-4cys-drug_457 _:Bd489bfa320c4853ad10e975f7f475b64|imgt:hasDesignation|imgt:Orphan_drug _:B9b3eb810ce60c88fe8321d09170c7c3e|rdf:type|obo:NCIT_C53285 imgt:Segment_102_1|imgt:has_rank|1 imgt:Product_05e00a74-7ade-3620-baac-283a328b8f7c|imgt:hasStudyProduct|imgt:StudyProduct_1affd692-dea5-3725-8845-f8fa9ca74d69 imgt:CTLA4|imgt:isTargetOf|imgt:IgG2-kappa_248 imgt:Product_b9e8379b-d30f-37fb-ac2e-44ad77f3f669|imgt:isProducedBy|imgt:Juno_Therapeutics imgt:%5BGH1_(growth_hormone_1_somatotropin_GH_GH-N_GHN_hGH-N_pituitary_growth_hormone)-PEG_linker%5D1-IGHG4_Fc_(Fragment_constant)|rdfs:label|[GH1 (growth hormone 1, somatotropin, GH, GH-N, GHN, hGH-N, pituitary growth hormone) - PEG linker]1 - IGHG4 Fc (Fragment constant) imgt:IgG1-kappa_1209|imgt:hasMolecularComponent|imgt:IG imgt:StudyProduct_ff1a9f4e-d90b-3b0f-aeee-532955fda8a4|rdfs:label|StudyProduct_ff1a9f4e-d90b-3b0f-aeee-532955fda8a4 imgt:IgG1-lambda_1108|rdfs:label|IgG1-lambda_1108 imgt:IgG4-kappa_802|http://semanticscience.org/resource/SIO_000291|imgt:C1S imgt:Product_05e00a74-7ade-3620-baac-283a328b8f7c|rdf:type|obo:NCIT_C51980 imgt:StudyProduct_0f00c99f-476f-3ffd-a6a2-b042fa4db1cd|imgt:hasDecision|_:B5267f7d7363951a03c105a9662dbc449 imgt:IgG1-kappa_522|obo:RO_0002162|imgt:Hum imgt:Segment_139_1|imgt:has_rank|1 imgt:StudyProduct_49da4a97-7e26-3138-8135-9bd4fc348fd1|imgt:isStudyProductOf|imgt:Product_0e424174-ac1f-3f3b-842b-0ddcc9a70b4d imgt:Product_5bdd4781-1f7e-3d2a-a7f9-bebb5a59b8db|imgt:commun_name|HL161 imgt:CPCA_PROTEIN-FC_820|imgt:hasConstruct|imgt:Construct_820 imgt:Rheumatoid_arthritis_(RA)|imgt:isClinicalIndicationOf|imgt:StudyProduct_61ff2dc5-66d9-3ec3-97ff-4109958d9b78 imgt:IFNAR2|imgt:isTargetOf|imgt:PROTEIN_1DOMAIN-PEG_741 imgt:mAb_530|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=530 imgt:Product_cd8476b5-acfd-34d9-919a-1998dd6cba5f|imgt:isProductOf|imgt:mAb_104 imgt:IgG1-kappa_805|imgt:hasMolecularComponent|imgt:IG imgt:StudyProduct_f47361f4-373b-374c-bd2d-cb5a37551e7c|imgt:hasClinicalPhase|imgt:Phase_II imgt:TNFRSF1A|rdf:type|imgt:RPILabel imgt:mAb_597|rdf:type|imgt:INN imgt:Segment_277_1|imgt:hasImgtLabel|imgt:IgG2-kappa imgt:StudyProduct_221229f0-28fe-3dc6-b1bd-975cbad03f98|rdfs:label|StudyProduct_221229f0-28fe-3dc6-b1bd-975cbad03f98 pubmed:8931129|rdfs:label|PMID_8931129 imgt:Construct_400|obo:BFO_0000051|imgt:Segment_400_1 imgt:Cancers|imgt:isClinicalIndicationOf|imgt:StudyProduct_bc9039b6-a991-3026-9681-be607e9c780f imgt:StudyProduct_23e351ab-c13b-3fcd-a885-935151f0ec57|rdfs:label|StudyProduct_23e351ab-c13b-3fcd-a885-935151f0ec57 imgt:Clone_1057|imgt:isOriginCloneOf|imgt:mAb_1057 imgt:Product_0e71815e-bc5c-3088-87f0-5fb9ca2d7a89|imgt:hasStudyProduct|imgt:StudyProduct_506a8738-be67-31c5-b7a4-40d5065a88ce imgt:mAb_1203|imgt:inn_number|11840 _:B810b881406ce1ca4eb9fcd40e6a5ab98|imgt:isDecidedBy|imgt:FDA imgt:11954|imgt:isImgtStructureEntryOf|imgt:mAb_1256 imgt:IgG2b-kappa_130|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG2b-kappa.png imgt:Construct_747|obo:BFO_0000051|imgt:Segment_747_1 imgt:Product_537eec38-79cb-325f-9881-34398d511aa7|imgt:isProductOf|imgt:mAb_167 imgt:StudyProduct_1204991a-cd46-3f61-85bb-d54a4922eb42|imgt:isStudyProductOf|imgt:Product_8e8a1379-1ce0-3a6f-bd30-ded74b8a8b53 imgt:IgG1-lambda_512|rdfs:comment|IgG1 - lambda imgt:Product_f4071a62-44ea-3bb4-9bb6-5c68735042f7|rdfs:label|Product_f4071a62-44ea-3bb4-9bb6-5c68735042f7 imgt:mAb_23|rdfs:label|mAb_23 imgt:Product_e0900857-baec-3ba7-84be-9d2b0fd497c6|imgt:isProducedBy|imgt:Protalex_Inc imgt:Product_07aac662-fdf7-3468-a89e-5ca369b8c228|imgt:hasStudyProduct|imgt:StudyProduct_a4579212-c26a-3666-8b80-15da493b5d2b imgt:StudyProduct_daf7b05a-33d0-3ddc-b2fe-426e50aa94f0|imgt:hasClinicalPhase|imgt:Phase_I/II imgt:L-V-J-C-chain|skos:definition|Identifies, for protein, molecule entities with a leader L region (immature form), a rearranged V region, a rearranged J region and a C region in undefined configuration. L-V-J-C-chain is in rearranged configuration; imgt:10780|rdfs:label|10780 imgt:isOrderedIn|rdf:type|owl:ObjectProperty imgt:mAb_1043|imgt:inn_number|11233 imgt:StudyProduct_b5954687-d408-39eb-bb39-9453ab30b9a1|imgt:application_type|Therapeutic imgt:Product_bba8672b-beba-3b1b-a573-c401cafeeb59|imgt:commun_name|JNJ-63898081 obo:NCIT_C98293|rdf:type|owl:Class imgt:5BVJ|rdfs:label|5BVJ imgt:mAb_170|imgt:inn_number|8332 imgt:Clone_140|imgt:clone_name|RB5 imgt:Segment_847_1|imgt:has_rank|1 imgt:StudyProduct_1bea8901-d037-3665-a4ef-0454a1fae171|imgt:hasClinicalPhase|imgt:Phase_M imgt:StudyProduct_7cce0a19-7542-3e6a-817e-a15921eca2f5|imgt:hasClinicalPhase|imgt:Phase_III imgt:F(ab’)2-Gamma-4_Lambda|imgt:isDefinedBy|imgt:IG-Heavy-Gamma-4-IGHG4 obo:NCIT_C174940|rdfs:subClassOf|obo:NCIT_C1909 imgt:Segment_1267_1|imgt:hasImgtLabel|imgt:IgG1-lambda imgt:Construct_372|rdf:type|imgt:Construct imgt:StudyProduct_f41ae699-17c8-38d8-a153-5c12ec20f37a|imgt:application_type|Therapeutic imgt:Product_1b93be2b-0d55-3628-845a-afdbb028443f|imgt:commun_name|CT-P59 imgt:mAb_372|imgt:inn_recommended_list|66 (2011) pubmed:16697465|dc:contributor|Mølhøj M _:B2940f36c870e7d879b4924b442c11232|imgt:isDecidedBy|imgt:FDA imgt:Ex_vivo_treatment_of_autologous_bone_marrow_and_subsequent_reinfusion|imgt:isClinicalIndicationOf|imgt:StudyProduct_732c9358-8d39-3fa0-b48b-532b199af3bb imgt:Product_8ce04d69-ff3a-3c28-a88f-ba8875ab2e2a|rdf:type|obo:NCIT_C51980 imgt:IgG1-kappa-%5BscFv%5D2-lambda_1260|imgt:hasConstruct|imgt:Construct_1260 imgt:EUSA_Pharma|imgt:produces|imgt:Product_7ee1000f-7a38-3b1d-9440-c9f59adf1731 imgt:IL1B|imgt:isTargetOf|imgt:IgG1-kappa_244 imgt:StudyProduct_30398458-77d5-32d6-8062-3cfe66167d41|rdf:type|obo:NCIT_C174271 imgt:Product_0018ff01-a960-34f5-a962-6894cb73438e|rdf:type|obo:NCIT_C51980 imgt:nyvepria™|imgt:isBiosimilarOf|imgt:mAb_616 imgt:Construct_48|imgt:isConstructOf|imgt:IgG1-kappa_48 imgt:PDCD1LG2|rdf:type|imgt:SegmentLabels imgt:Segment_163_1|rdf:type|imgt:Segment obo:BFO_0000051|skos:definition|Inverse of part_of. imgt:Construct_1128|imgt:isConstructOf|imgt:IgG4-kappa_1128 imgt:Product_6942fb15-771a-33c8-bb83-07688b78a15b|rdfs:label|Product_6942fb15-771a-33c8-bb83-07688b78a15b imgt:Cardiac_myxoma|rdfs:label|Cardiac_myxoma imgt:StudyProduct_5356f694-856b-32e0-a1c4-d3295004fcbf|rdfs:label|StudyProduct_5356f694-856b-32e0-a1c4-d3295004fcbf imgt:IgG1-kappa_726|imgt:hasConstruct|imgt:Construct_726 imgt:Construct_429|rdf:type|imgt:Construct imgt:Product_7c5b4231-8351-3ed9-ba1d-8c48699ed506|imgt:isProductOf|imgt:mAb_512 imgt:11436|imgt:isImgtStructureEntryOf|imgt:mAb_1077 imgt:Genentech_Inc|imgt:produces|imgt:Product_cfe151a6-7bb2-3ece-b611-96636f3e77a4 imgt:Segment_1238_1|obo:BFO_0000050|imgt:Construct_1238 imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_16d4da35-58bb-399a-894b-7f3c3443aab9 imgt:StudyProduct_ebae25c4-1751-3f03-935f-833a3a2334c3|imgt:hasExpressionSystem|imgt:_CHOK1SV_(expresses_glutamine_synthetase_(GS)_endogenously)_cells imgt:Product_d3b3ee2c-a59b-36a5-a62a-c351fa3e366e|imgt:isProducedBy|imgt:AstraZeneca imgt:Product_92aaaa11-a012-35e5-91ee-9df570fa89a7|imgt:hasStudyProduct|imgt:StudyProduct_8fafb39d-a882-31f1-80c7-29f8cbf3627b imgt:StudyProduct_fe6a6dcb-b974-3272-b7e1-eba9e336f6d2|rdf:type|obo:NCIT_C174271 imgt:mAb_1169|imgt:hasImgtStructureEntry|imgt:11632 imgt:IgG1-kappa-4lys-drug_52|imgt:conjugated_with| maytansinoid DM1 imgt:StudyProduct_c51e3bd8-108d-39e1-b6c7-e52a7b327339|imgt:application_type|Therapeutic imgt:10903|rdfs:label|10903 imgt:mAb_1023|imgt:inn_number|11309 imgt:StudyProduct_6ba65a28-3657-3e97-b336-766e043f01f2|rdfs:label|StudyProduct_6ba65a28-3657-3e97-b336-766e043f01f2 imgt:Dermatological_genetic_disorders|rdf:type|obo:NCIT_C185637 imgt:9447|rdfs:label|9447 imgt:hasMabReceptor|rdfs:domain|obo:NCIT_C1909 imgt:Product_1f7a8336-e6de-3d18-98e3-0ab463681d68|rdf:type|obo:NCIT_C51980 imgt:mAb_38|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=38 imgt:mAb_1276|imgt:hasOriginClone|imgt:Clone_1276 imgt:TNFRSF13C|rdf:type|obo:NCIT_C25702 imgt:StudyProduct_574ed8bf-743e-3214-8ea1-9fb1f08c84a9|rdf:type|obo:NCIT_C174271 imgt:_CHOK1SV_(lacking_the_glutamine_synthetase_(GS)_gene)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_d790e869-4e7c-36d6-bac0-07c0818036ec imgt:Construct_1105|imgt:isConstructOf|imgt:IgG1-kappa_1105 imgt:CD74|imgt:isTargetOf|imgt:IgG1-kappa_135 imgt:FGFR1|rdf:type|obo:NCIT_C25702 imgt:mAb_174|imgt:inn_proposed_list|101 (2009) obo:NCIT_C170758|rdfs:subClassOf|obo:NCIT_C1909 imgt:9439|rdf:type|obo:NCIT_C25402 imgt:Product_0517e477-c651-3706-be63-d3b291cef5f7|imgt:isProducedBy|imgt:Micromet_Inc imgt:Segment_374_1|imgt:has_rank|1 imgt:IgG1-kappa_36|imgt:hasConstruct|imgt:Construct_36 imgt:IG-Heavy-Gamma-4-IGHG4|imgt:defines|imgt:F(ab’)2-Gamma-4_Kappa imgt:StudyProduct_bbf45e5e-377b-3639-b622-b079804455bc|rdf:type|obo:NCIT_C174271 imgt:J-HEPTAMER|rdf:type|imgt:HeptamerLabel imgt:Product_8cbc64f1-a09e-3b24-8971-ec6382ae015a|imgt:hasStudyProduct|imgt:StudyProduct_b1f755db-a205-37b9-a833-082549620702 imgt:StudyProduct_e10fb030-a327-3e32-9249-263591627ebd|imgt:hasClinicalPhase|imgt:Phase_M imgt:Product_37f1c052-5249-3881-9f48-76440121e0dd|imgt:commun_name|BTT1023 imgt:StudyProduct_f8928c21-029a-311e-a5ae-b2505b18b929|rdfs:label|StudyProduct_f8928c21-029a-311e-a5ae-b2505b18b929 imgt:TR-Gamma-1-TRGC1|imgt:defines|imgt:TR-Gamma-1_Delta imgt:Clone_547|imgt:isOriginCloneOf|imgt:mAb_547 imgt:Construct_201|imgt:isConstructOf|imgt:IgG1-kappa_201 imgt:Product_c7cf4dec-df13-33c9-9a7e-798c0993539c|imgt:commun_name|interferon alfa-2b imgt:Product_1081ab17-8cd8-3029-854d-33096639ce86|imgt:isProductOf|imgt:mAb_241 imgt:StudyProduct_d2145572-8fa1-3560-8662-8fefc008eb2f|rdfs:label|StudyProduct_d2145572-8fa1-3560-8662-8fefc008eb2f imgt:Product_c7359b30-f05b-3766-9171-fb55d36b7b20|rdf:type|obo:NCIT_C51980 imgt:Construct_289|imgt:isConstructOf|imgt:PROTEIN_2DOMAINS_VLIKE_CLIKE-TOXIN_2DOMAINS_289 imgt:Product_5c35ec7d-f892-34d7-a57f-2709a11d3612|imgt:commun_name|AT-005 imgt:IgG1-kappa_334|rdfs:comment|IgG1 - kappa imgt:StudyProduct_f20e1847-2c26-3e78-a491-12156e44a0da|rdfs:label|StudyProduct_f20e1847-2c26-3e78-a491-12156e44a0da imgt:mAb_110|imgt:hasMabReceptor|imgt:MAbReceptor_110 imgt:FUSION-%5BF10%5D2-FC-GAMMA-1|skos:definition|Fusion protein for immune application (FPIA) comprising F10 fused with immunoglobulin G1 FC fragment imgt:Clone_54|obo:RO_0002162|imgt:Musmus imgt:Segment_864_1|imgt:hasImgtLabel|imgt:IgG4-kappa imgt:Construct_1247|imgt:hasImgtLabel|imgt:IgG1-lambda2 imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_1262459b-5fb7-3613-be73-bb5ee75f51e3 imgt:StudyProduct_fade80e3-dac2-35bc-8e4a-2c6290e838ca|imgt:application_type|Therapeutic imgt:mAb_366|imgt:hasProduct|imgt:Product_e307cb3e-aef8-35ec-8bfb-bee27d4d2030 imgt:IgG4-kappa_574|rdfs:label|IgG4-kappa_574 obo:NCIT_C152971|rdf:type|owl:Class imgt:Chronic_Obstructive_Pulmonary_Disease_(COPD)|rdf:type|obo:NCIT_C185637 imgt:Segment_1298_1|imgt:has_rank|1 imgt:StudyProduct_760fad9c-0830-3288-a159-d62895ffea3e|imgt:hasClinicalIndication|imgt:Rheumatoid_arthritis_(RA) imgt:IgG1-kappa_764|rdf:type|imgt:MAbReceptor imgt:StudyProduct_7bdae3a6-f002-3c63-ad70-602ffe8d056e|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_34235bce-3bdc-381d-afe4-251c5a169db0|imgt:hasClinicalIndication|imgt:Dementia_Alzheimer_s_type imgt:NT5E|imgt:isTargetOf|imgt:IgG1-lambda_729 imgt:Clone_1194|imgt:isOriginCloneOf|imgt:mAb_1194 imgt:10661|rdf:type|obo:NCIT_C25402 imgt:Solid_tumors|imgt:isClinicalIndicationOf|imgt:StudyProduct_c3210182-72fe-3ac7-8e95-7595f4a95224 imgt:IG-Heavy-Alpha|imgt:defines|imgt:IgA_Lambda imgt:StudyProduct_09df3e91-f429-3b15-9a77-4979462fba4c|imgt:hasClinicalIndication|imgt:Cancers_breast_overexpressing_ERBB2_metastatic imgt:StudyProduct_d7ff2e98-d0a2-3351-9cd5-54d89f2815bc|imgt:application_type|Therapeutic imgt:L-IOTA|imgt:describes|imgt:IG-Light-Iota-IGI imgt:Hypophosphatemia_X-linked_(Hereditary_hypophosphatemic_rickets)|rdfs:label|Hypophosphatemia_X-linked_(Hereditary_hypophosphatemic_rickets) imgt:StudyProduct_5cf0c516-2972-37f2-ab70-2c2d6e4acfc6|imgt:hasClinicalIndication|imgt:Solid_tumors imgt:9810|imgt:isImgtStructureEntryOf|imgt:mAb_475 imgt:IgG1-kappa_1264|rdfs:comment|IgG1 - kappa imgt:mAb_134|imgt:hasMabReceptor|imgt:F(ab%27)2-G1-nd_134 imgt:10060|rdfs:label|10060 imgt:INSERM|rdfs:comment|Montpellier , France imgt:StudyProduct_bfd883d2-e43c-3903-a065-ed4bcf5cd904|imgt:development_technology| Medarex’s UltiMAb® imgt:Construct_407|imgt:isConstructOf|imgt:IgG1-kappa_407 imgt:Cancers_bladder|imgt:isClinicalIndicationOf|imgt:StudyProduct_b5bb588b-b379-31c3-9058-a22e42f60488 _:B3d24548d0c2287c74b9a3697dbea474f|imgt:isDecisionOf|imgt:StudyProduct_7eed1a8e-d42d-3f3a-bba2-e7cb464b9202 imgt:StudyProduct_8a9cd26d-f333-3b71-8411-80fdfab1538b|imgt:application_type|Therapeutic pubmed:21330330|dc:contributor|Vismara E imgt:StudyProduct_5639027b-0512-36e7-9124-f6078d40b39b|imgt:hasClinicalIndication|imgt:Glioblastoma_multiforme_(GBM) imgt:Segment_544_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Clone_87|imgt:isOriginCloneOf|imgt:mAb_87 imgt:StudyProduct_0756fd89-b6c2-3995-a23f-9cc99dd06136|rdfs:label|StudyProduct_0756fd89-b6c2-3995-a23f-9cc99dd06136 imgt:Construct_351|rdf:type|imgt:Construct imgt:Product_e5f2774f-12a5-3152-ba54-ccfdc2d08d29|rdf:type|obo:NCIT_C51980 imgt:Product_c5151247-b44f-3bba-8959-84807369fc7c|rdf:type|obo:NCIT_C51980 imgt:Product_aac2ba8b-69b0-31aa-b7c9-b2dc4b8f4de6|imgt:isProducedBy|imgt:Morphotek_Inc imgt:mAb_853|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=853 imgt:StudyProduct_8a6d066c-b385-3587-a404-674ccff69832|imgt:application_type|Therapeutic imgt:StudyProduct_91d1e008-c2d8-3b4c-8b31-e5faddcb4b37|imgt:hasDecision|_:B9c1f1837c3effbe131e9b79fa2c3764a imgt:Construct_104|imgt:isConstructOf|imgt:IgG1-nd_104 imgt:StudyProduct_9cf7da6f-4b72-3b2f-a8ca-1a7449fbbe45|rdfs:label|StudyProduct_9cf7da6f-4b72-3b2f-a8ca-1a7449fbbe45 imgt:Segment_497_1|rdf:type|imgt:Segment imgt:StudyProduct_42ac6055-5e5c-3716-b033-4b0d44da0042|imgt:isStudyProductOf|imgt:Product_eee3061f-bf14-3e3d-9646-c7c2fe6d3166 imgt:Inflammatory_conditions_acute_and_chronic|imgt:isClinicalIndicationOf|imgt:StudyProduct_84e32db6-70db-3328-968a-3daaa74a54bd imgt:Segment_817_1|rdf:type|imgt:Segment imgt:Eli_Lilly|imgt:produces|imgt:Product_afbf7fd5-a1d9-3e32-a5a3-10bbf3a99dee imgt:CD47|rdf:type|obo:NCIT_C25702 imgt:StudyProduct_ab1d04b4-a734-34a0-9c31-f20769a0c924|rdfs:label|StudyProduct_ab1d04b4-a734-34a0-9c31-f20769a0c924 imgt:mAb_580|rdfs:label|mAb_580 imgt:IgG1-kappa_1028|imgt:hasConstruct|imgt:Construct_1028 imgt:Anaplastic_large_cell_lymphoma_(ALCL)|imgt:isClinicalIndicationOf|imgt:StudyProduct_8a84372d-24b7-33d8-9f94-7a6a1fe6782b imgt:StudyProduct_bcd84b48-b116-3270-92e4-33d66f0c7e74|imgt:application_type|Therapeutic imgt:Segment_733_2|imgt:has_rank|2 _:B922e2926ccbb9b10c5ff67ebf080e18a|imgt:isDecidedBy|imgt:FDA imgt:Construct_387|obo:BFO_0000051|imgt:Segment_387_1 _:B32b546605a004397d1839ab94d5b63c4|dc:date|2011-02-08 imgt:IgG1-kappa_1060|obo:RO_0002162|imgt:Chi imgt:Immunex_Corporation_Amgen|imgt:produces|imgt:Product_f05098e0-166e-3680-9f12-888766e2989e obo:NCIT_C128799|rdf:type|owl:Class imgt:StudyProduct_fb78a4cd-b2e0-315b-8b9f-bd068891e6ee|imgt:hasExpressionSystem|imgt:_CHOK1SV_(lacking_the_glutamine_synthetase_(GS)_gene)_cells imgt:Segment_767_1|obo:BFO_0000050|imgt:Construct_767 imgt:IgG1-nd_164|http://semanticscience.org/resource/SIO_000291|imgt:EPCAM imgt:Segment_425_1|rdfs:label|Segment_425_1 imgt:Product_4df40ab5-5d0f-30b1-ace2-8864d92bc14b|imgt:isProducedBy|imgt:Ridgeback_Biotherapeutics_LP imgt:StudyProduct_7e747b42-756f-362e-bf69-d6b3856a8ba4|imgt:hasClinicalPhase|imgt:Phase_I imgt:mAb_531|imgt:imgt_note| vandortuzumab vedotin INN disulfide bridge location ‘Intra-H (C23-C104)’ is that amended in L113 (2015) and published in R74 (2015). imgt:mAb_1271|imgt:hasImgtStructureEntry|imgt:12361 imgt:IgG2b-kappa_1096|http://semanticscience.org/resource/SIO_000291|imgt:CD3E imgt:StudyProduct_c175e745-f820-3535-a583-cecc65a29f5f|imgt:development_technology| POTELLIGENT® technology (afucosylation) SIMPLE Antibody™ imgt:Product_c545816c-e16f-3035-a4bc-97ae27507d0d|imgt:hasStudyProduct|imgt:StudyProduct_c2bd6159-8e75-386c-9f57-f367043b6bb0 imgt:Construct_460|rdf:type|imgt:Construct imgt:IgG4_Kappa|imgt:isDefinedBy|imgt:IG-Light-Kappa-IGKC imgt:BMP10|rdfs:label|BMP10 imgt:mAb_569|imgt:hasImgtStructureEntry|imgt:10141 imgt:CA_exendin-4|rdfs:label|CA exendin-4 imgt:mAb_998|rdfs:label|mAb_998 imgt:StudyProduct_cb415f04-8f17-3d90-b008-249903036395|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:Segment_1059_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:mAb_205|rdfs:label|mAb_205 imgt:StudyProduct_3df0a65e-d2ff-3ee8-9818-bff374a469fa|imgt:isStudyProductOf|imgt:Product_804344aa-9846-368c-b3c2-764390d1bcc8 imgt:Product_d8f8f32a-4a56-3077-910a-bd55a9d0cae3|rdf:type|obo:NCIT_C51980 imgt:IgG4-kappa_1180|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG4-kappa.png imgt:Construct_249|imgt:isConstructOf|imgt:IgG2-kappa_249 imgt:IgG1-kappa_577|http://semanticscience.org/resource/SIO_000291|imgt:F3 imgt:Colchicine-resistant_Familial_Mediterranean_fever_(FMF)|rdfs:label|Colchicine-resistant_Familial_Mediterranean_fever_(FMF) imgt:undefined|skos:definition|Identifies, whatever the molecule type, the configuration of the conventional genes and that of the IG and TR constant (C) genes, and by extension, the configuration of the Molecule_EntityType leafconcepts that only contain genes in undefined configuration. imgt:mAb_616|imgt:inn_number|8114 imgt:StudyProduct_a7811b4e-4519-3e4d-87c6-9e1f3528a52a|rdfs:label|StudyProduct_a7811b4e-4519-3e4d-87c6-9e1f3528a52a imgt:mAb_1012|imgt:hasMabReceptor|imgt:IgG1-kappa_1012 _:Bf63055356bc5c60ef55f90683651e0f2|imgt:isDecisionOf|imgt:StudyProduct_24a5b3e1-d940-3209-bb75-5ed7d27e6ec6 imgt:Construct_646|rdf:type|imgt:Construct obo:NCIT_C174956|rdfs:subClassOf|obo:NCIT_C1909 imgt:IG-Heavy-Gamma-2-c-IGHG2C|imgt:defines|imgt:IgG2c_Kappa imgt:Neoprobe_Corp|rdfs:label|Neoprobe Corp. imgt:mAb_184|rdfs:label|mAb_184 imgt:StudyProduct_6bae9e91-12f7-3b99-89d5-7e63a5f2d57e|imgt:hasDecision|_:Bd406380c7b72a7ab0caf869fbf0891fa imgt:StudyProduct_3938e3bf-5caa-3bde-a890-4e5001b4a0ae|imgt:hasDecision|_:B732c59ec45f9dd6d9d7f828e8ec9e602 imgt:mAb_443|rdfs:label|mAb_443 _:B5ebf0da577c90c199924e89ce1cdbe2f|imgt:hasDesignation|imgt:Orphan_drug imgt:Segment_492_1|rdf:type|imgt:Segment imgt:mAb_486|rdf:type|obo:NCIT_C171829 imgt:Segment_790_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:StudyProduct_f43e9ef9-e92b-34f3-ba85-ac3eb7e8e36c|imgt:hasClinicalPhase|imgt:Phase_I _:Bb23dd2bc585b4e061dc43d835d8fc2f8|imgt:isDecidedBy|imgt:EMA imgt:StudyProduct_053d3539-2a6d-389b-a439-57ca9bc99d1c|imgt:hasClinicalPhase|imgt:Phase_II imgt:VH-VH%27_1253|rdf:type|imgt:MAbReceptor imgt:Construct_688|rdf:type|imgt:Construct imgt:Product_2fe9dc72-d473-3067-9bd5-11392ca71f36|imgt:comercial_name|VABYSMO™ imgt:Product_380468a1-298c-37f8-8d02-622fb021aa02|imgt:isProductOf|imgt:mAb_1131 imgt:fulphila™|rdf:type|obo:NCIT_C156644 imgt:Segment_528_1|obo:BFO_0000050|imgt:Construct_528 imgt:StudyProduct_85864ad3-8f09-311e-8dd6-1b36987160d2|imgt:hasDecision|_:B43b7d374858e7912ceb10f9e07cfa87f imgt:StudyProduct_6f3ded54-f936-3d37-9f9a-66c98aaceb0f|imgt:application_type|Therapeutic imgt:mAb_55|rdf:type|obo:NCIT_C1909 obo:NCIT_C1960|rdf:type|owl:Class imgt:Product_811fe504-a8bf-3b42-ac45-867ba561364b|imgt:hasStudyProduct|imgt:StudyProduct_198071b8-33f2-34af-af3c-077bd6f0ca62 imgt:Cancers_breast|imgt:isClinicalIndicationOf|imgt:StudyProduct_bb3319d9-9bf0-3ca2-8bea-3859c50d58bf imgt:StudyProduct_841da9d4-eab8-3973-a541-2579f86bf7d0|imgt:hasClinicalIndication|imgt:Tenosynovial_giant_cell_tumor_(TGCT) imgt:Product_ed1e8186-4f31-37d5-85c3-9b5b8b1a524f|imgt:hasStudyProduct|imgt:StudyProduct_409d27d0-5a79-3870-b133-3a8e6a4e072f imgt:Product_b9e8379b-d30f-37fb-ac2e-44ad77f3f669|imgt:hasStudyProduct|imgt:StudyProduct_b8543b44-c170-31d9-9985-bdcaa45b9a1d imgt:IG-MU_KAPPA|skos:definition|IG receptor comprising two H-MU and two L-KAPPA chains imgt:mAb_838|imgt:inn_recommended_list|85 (2021) imgt:Product_0477f890-c9d2-3f6e-a320-339542f67ab5|imgt:hasStudyProduct|imgt:StudyProduct_dc26fde7-cb9d-3892-b45e-3a160680390a imgt:Psoriasis|imgt:isClinicalIndicationOf|imgt:StudyProduct_6bee57a7-bbc1-366d-8257-595e1dceb7b6 imgt:StudyProduct_f546d8a8-dbdd-37c5-ad86-10969591ce76|imgt:development_technology| Medarex’s UltiMAb® imgt:Segment_1179_1|imgt:has_rank|1 imgt:Construct_727|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:8959|imgt:isImgtStructureEntryOf|imgt:mAb_232 _:B0abbd7bc1992c7e2b52a94909e6d59a7|imgt:hasStatut|imgt:approval imgt:MRC_Technology|imgt:produces|imgt:Product_c1583c88-e53a-3e51-9a2c-fabecf1e8960 imgt:IgG4-kappa_851|rdfs:comment|IgG4 - kappa imgt:StudyProduct_14857b94-bdbd-375d-bdb5-a38f05a59a47|imgt:hasClinicalPhase|imgt:Phase_I imgt:mAb_882|imgt:inn_recommended_list|83 (2020) imgt:Influenza|rdfs:label|Influenza imgt:StudyProduct_629d4aff-1483-3f88-bf03-a1d3ebc3a37e|imgt:isStudyProductOf|imgt:Product_00f7b7b0-4e5e-3823-a5cc-5b62bbf6300f imgt:Product_40fd3b5d-f917-3fed-97f6-62ec12bc834e|imgt:hasStudyProduct|imgt:StudyProduct_15a0a4ce-6b3c-34bc-9df1-8eb1c35bc123 imgt:12129|imgt:isImgtStructureEntryOf|imgt:mAb_1164 imgt:StudyProduct_409d27d0-5a79-3870-b133-3a8e6a4e072f|rdfs:label|StudyProduct_409d27d0-5a79-3870-b133-3a8e6a4e072f imgt:StudyProduct_cfcfdb97-fa02-3890-8459-d5defed66faa|imgt:application_type|Therapeutic imgt:FUSION-%5BTHPO%5D2-FC-GAMMA-4|skos:definition|Fusion protein for immune application (FPIA) comprising THPO fused with immunoglobulin G4 FC fragment imgt:CD19|imgt:isTargetOf|imgt:scFv-heavy-kappa-scFv-kappa-heavy-CD8A(CO-TM)-TNFRSF9(CY)-CD247_1161 imgt:Memorial_Sloan-Kettering_Cancer_Center|rdfs:label|Memorial Sloan-Kettering Cancer Center imgt:Enobia_pharma|rdf:type|obo:NCIT_C54131 _:Bbcf60af8acc8fb5e1dcd77131b6d68c9|rdf:type|obo:NCIT_C53285 imgt:StudyProduct_e09ced69-a82d-3408-a2f1-7c8527eafb37|imgt:hasClinicalPhase|imgt:Phase_M imgt:(scFv-heavy-kappa)-h-CH2-CH3|rdf:type|imgt:ConstructLabels imgt:StudyProduct_61a5914e-5af5-35d9-96f6-491cc8d3f099|rdf:type|obo:NCIT_C174271 imgt:mAb_615|imgt:hasProduct|imgt:Product_8892de96-5fe3-389f-a136-98d4bfc4724a imgt:Medarex|rdfs:comment|Princeton , USA imgt:mAb_930|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=930 imgt:Product_e606d79d-bde1-3cc6-a544-20c1bf6683c4|imgt:hasStudyProduct|imgt:StudyProduct_1fb6363e-1126-3c35-9f7a-641a367792e6 imgt:Construct_802|rdf:type|imgt:Construct imgt:CIS_Bio_international|rdfs:label|CIS Bio international imgt:Segment_431_1|imgt:has_rank|1 imgt:BRAF_wild-type_melanoma_metastatic_or_unresectable|rdfs:label|BRAF_wild-type_melanoma_metastatic_or_unresectable imgt:IL17A|rdf:type|obo:NCIT_C25702 imgt:scFv-h-CH2-CH3(_scFv)_h-CH2-CH3_|imgt:construction_detail|scFv -h-CH2-CH3(_scFv)_h-CH2-CH3 imgt:L-V-D-SEQUENCE|rdfs:label|L-V-D-SEQUENCE imgt:%5B(scFv-heavy-kappa)-IGHE-CH4%5D2|rdf:type|imgt:ConstructLabels imgt:mAb_777|rdf:type|imgt:INN imgt:Hepatitis_B_reinfection_in_liver_transplant_patients|imgt:isClinicalIndicationOf|imgt:StudyProduct_94244cbd-18b6-3fc6-b55a-43ecf1366510 pubmed:7532786|rdf:type|bibo:Article imgt:Nektar_Therapeutics|rdf:type|obo:NCIT_C54131 imgt:StudyProduct_4cdd49cd-0f02-370e-95fe-8121a698d4fe|imgt:isStudyProductOf|imgt:Product_dcd644d4-d907-3989-acc6-6c340412800f imgt:3'D-SPACER|owl:sameAs|obo:SO_0000495 imgt:mAb_956|rdf:type|obo:NCIT_C156741 imgt:IgG1-kappa_367|imgt:isMabReceptorOf|imgt:mAb_367 imgt:Visterra_Inc|rdfs:comment|Waltham , USA imgt:StudyProduct_3449776c-d9a1-37be-b4e5-1aaf903cfe69|imgt:hasClinicalPhase|imgt:Phase_III imgt:IgG1-kappa_156|imgt:hasConstruct|imgt:Construct_156 imgt:Segment_1046_1|imgt:has_rank|1 _:B6262a01e127f92cce188edb49a63eff2|dc:date|2017-05-09 imgt:Product_db3d4ac6-821a-3423-ba1d-61b8ad6cf363|imgt:hasStudyProduct|imgt:StudyProduct_bb3319d9-9bf0-3ca2-8bea-3859c50d58bf imgt:StudyProduct_0f00c99f-476f-3ffd-a6a2-b042fa4db1cd|imgt:hasClinicalIndication|imgt:Thrombotic_thrombocytopenia_purpura_(TTP)_acquired imgt:IgG4-kappa_563|rdfs:comment|IgG4 - kappa imgt:BC-LOOP|rdfs:label|BC-LOOP imgt:Product_f272da3d-d319-39ce-a72e-2eaf8b604878|imgt:commun_name|CDP870 imgt:Construct_841|obo:BFO_0000051|imgt:Segment_841_1 imgt:StudyProduct_4ef4b397-36e2-3e59-a016-663f2fbdafd8|imgt:hasDecision|_:B8ca398a0824e7a0ec4900c3b0c15658d imgt:CHS|rdf:type|imgt:C-RegionExonLabel imgt:Segment_241_1|rdfs:label|Segment_241_1 imgt:PROTEIN_2DOMAINS_933|imgt:hasMolecularComponent|imgt:CPCA imgt:Product_f0221536-d202-3194-8a6c-80a5b460de1b|imgt:comercial_name|ADUHELM™ imgt:mAb_25|rdfs:label|mAb_25 imgt:mAb_1138|imgt:inn_proposed_list|124 (2020) _:B538494a9338f7fda23c3f10ec07a735f|imgt:hasDesignation|imgt:Orphan_drug imgt:Product_8a843cd1-05ec-3b12-8269-e99f43ea2baf|rdfs:label|Product_8a843cd1-05ec-3b12-8269-e99f43ea2baf imgt:Segment_977_1|imgt:has_rank|1 imgt:CSL_Behring|imgt:produces|imgt:Product_36499f25-0f6a-3c54-aaa7-38cca0d2f3ac imgt:10467|rdf:type|obo:NCIT_C25402 _:Ba925ee08a37e042c9607cb07b9d36ec3|imgt:isDecidedBy|imgt:EMA _:Bf006bcfe31c673437e46a93744325b96|imgt:isDecidedBy|imgt:FDA imgt:IgG1-kappa_450|http://semanticscience.org/resource/SIO_000291|imgt:IL23A imgt:Product_b874e91f-5c72-30ea-8bd2-f0bf2e6cc591|imgt:hasStudyProduct|imgt:StudyProduct_77aa179b-ea76-31b2-9bd8-8288232f87f0 imgt:StudyProduct_76bc383b-6576-3677-b0c2-72abff042665|imgt:application_type|Therapeutic imgt:StudyProduct_0f54f11d-72e5-3cd1-a127-6ddf3cf72382|imgt:hasClinicalIndication|imgt:Cancers_colorectal_(CRC) imgt:Construct_667|imgt:hasImgtLabel|imgt:IgG2-kappa imgt:StudyProduct_37b60253-eaac-3cee-8a38-6976322a07a5|imgt:hasClinicalIndication|imgt:Cancers_ovarian imgt:StudyProduct_0dc612ec-c898-3353-a1ea-859f6293c2cf|imgt:application_type|Therapeutic obo:NCIT_C152224|rdf:type|owl:Class obo:NCIT_C152308|rdfs:subClassOf|obo:NCIT_C1909 imgt:Product_a4d4a5e8-f868-388c-87fe-5d2336f3206d|imgt:hasStudyProduct|imgt:StudyProduct_15a257d3-e7cf-393d-9482-4fadc2a060bb imgt:Product_a5c1a1b9-506a-361d-a62c-eee6f10d449a|rdfs:label|Product_a5c1a1b9-506a-361d-a62c-eee6f10d449a _:B45a5b30edbe6b634d5a616060ed9f340|dc:date|2009-04-24 imgt:mAb_1199|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=1199 imgt:StudyProduct_6bcaa017-20d4-3c2e-a4d7-adb692916142|imgt:hasClinicalPhase|imgt:Phase_M imgt:Cancers_non-small_cell_lung_(NSCLC)|imgt:isClinicalIndicationOf|imgt:StudyProduct_bb657515-54e5-392c-a891-61c8e3ea325b imgt:Product_9f4bb904-79a4-3feb-b45a-020e11d81a35|imgt:commun_name|BIVV020 imgt:mAb_982|rdf:type|obo:NCIT_C142890 imgt:INSR|imgt:isTargetOf|imgt:ELP-PEPTIDE_745 pubmed:18088084|imgt:isBibliographicReferenceOf|imgt:mAb_64 imgt:_Pichia_pastoris_(Komagataella_pastoris)|imgt:isExpressionSystemOf|imgt:StudyProduct_b0dad6c0-b927-3321-8f38-6f26d945289d imgt:mAb_867|rdf:type|obo:NCIT_C166680 imgt:mAb_376|rdf:type|obo:NCIT_C166971 imgt:Clone_1192|rdfs:label|Clone_1192 imgt:Clone_1077|imgt:clone_name|91@ 2B7-1B3 7A4D imgt:Construct_1183|imgt:isConstructOf|imgt:IgG4-kappa-lambda_1183 imgt:TNFSF4_(Pr1-183)|rdf:type|imgt:DomainLabel imgt:StudyProduct_da5ccc3d-ad58-3594-8f96-7cc55262d8fc|rdf:type|obo:NCIT_C174271 imgt:GPNMB|imgt:isTargetOf|imgt:IgG2-kappa_332 imgt:J-C-SEQUENCE|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/IMGTScientificChart/SequenceDescription/Prototypes/J-C-sequence.png imgt:Construct_663|rdfs:label|Construct_663 pubmed:16699037|dc:contributor|Kaizu M imgt:Neutropenia_associated_with_bone_marrow_transplant|rdf:type|obo:NCIT_C185637 imgt:Product_2ac5f9dd-3aa5-3b90-9b7c-53e60c91c010|imgt:hasStudyProduct|imgt:StudyProduct_85b6b72e-1238-3b69-a3e0-ce8bd39a5396 imgt:mAb_1094|imgt:hasImgtStructureEntry|imgt:11502 imgt:mAb_5|imgt:hasProduct|imgt:Product_d4d1bdb9-b3e4-30fa-92e8-5ac4648af400 imgt:Construct_490|rdf:type|imgt:Construct imgt:mAb_938|imgt:inn_proposed_list|121 (2019) imgt:StudyProduct_f0b8db0f-c770-338b-9507-40d0d2a0c9b3|imgt:isStudyProductOf|imgt:Product_7832c9e8-c4d7-3ca7-8c44-6880985116a0 imgt:C-DomainLabel|rdfs:label|C-DomainLabel https://doi.org/10.1093/protein/7.12.1501|dc:contributor|Williamson E.D. imgt:IgG1-kappa_1023|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:Product_75eafa99-1920-3a21-9a27-a04a05a3e0ec|imgt:isProductOf|imgt:mAb_632 imgt:StudyProduct_38804e2c-8020-32ad-8f9e-7e0a6981e8ab|imgt:hasClinicalIndication|imgt:Ankylosing_spondylitis_(AS) imgt:StudyProduct_315bec76-5b76-3d31-aa7a-1f20daf0d0d0|imgt:hasClinicalIndication|imgt:Staphylococcal_infections imgt:mAb_651|imgt:inn_recommended_list|77 (2017) imgt:CPCA_PROTEIN_BIG-FC_520|obo:RO_0002162|imgt:Homsap imgt:Product_55aa2dba-a058-31a7-91b8-376994712cb7|imgt:hasStudyProduct|imgt:StudyProduct_c905f749-92b7-35ce-8e77-1bb48e3bca6a imgt:StudyProduct_319335a0-2bef-3d34-bb33-1ba138c412f9|imgt:hasDecision|_:Be8a20742098bdb2bb357b213131a19ec imgt:StudyProduct_7d67a48d-3457-3319-b4c3-2b01b733859c|imgt:hasClinicalPhase|imgt:Phase_I/II imgt:LOXL2|imgt:isTargetOf|imgt:IgG4-kappa_430 imgt:IgG4-kappa_574|imgt:hasConstruct|imgt:Construct_574 imgt:Autoimmune_diseases|imgt:isClinicalIndicationOf|imgt:StudyProduct_024b4b67-b3a6-3886-a04b-f0a3feef3807 imgt:mAb_326|rdf:type|imgt:INN imgt:Product_ceb3912e-1a2a-3355-bb97-cead13a7b3ac|imgt:commun_name|MSB-2311 imgt:Segment_1240_1|imgt:has_rank|1 imgt:StudyProduct_3a66b5f8-3b74-3e8e-838b-da3893b82e7e|imgt:hasDecision|_:Ba247da921a82ca27f62faea2bc01e5d6 imgt:IL2RA|imgt:isTargetOf|imgt:IgG1-kappa-%5BPROTEIN%5D2_1223 pubmed:7858182|dc:date|1994 imgt:IgG4-kappa_977|imgt:hasConstruct|imgt:Construct_977 imgt:FV-HEAVY_LAMBDA|imgt:describes|imgt:Fv-Heavy_Lambda imgt:Product_49163033-f1a0-30ca-bfdb-018ea05fa05b|imgt:isProductOf|imgt:mAb_1253 imgt:StudyProduct_58071149-f02d-3be0-9617-339e652fbe0f|imgt:isStudyProductOf|imgt:Product_25796472-061c-3bdc-bd4c-5380a1f40cba imgt:Fab|skos:definition|Identifies the fragment antigen binding of an IG (or antibody) obtained by papain digestion or in vitro construct. An Fab consists of the Fd (VH+CH1) heavy chain fragment linked by a disulfide bond to the light chain (VL+CL). imgt:StudyProduct_0b0eb6d1-395c-39d8-bfe6-44ba43482a6e|imgt:application_type|Therapeutic imgt:IgG4-kappa_447|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG4-kappa.png imgt:Product_b1370aed-0f04-32a5-9fa3-29cf7e6cb0c7|imgt:comercial_name|LEUKINE® imgt:Construct_398|rdfs:label|Construct_398 imgt:IgG1-kappa|rdfs:label|IgG1 - kappa imgt:Cancers_colorectal_microsatellite_stable_metastatic|rdfs:label|Cancers_colorectal_microsatellite_stable_metastatic imgt:Facet_Biotech|rdfs:comment|Redwood City , USA imgt:StudyProduct_ada272da-4f74-3360-85fc-7b3242f1c864|imgt:hasClinicalPhase|imgt:Discontinued imgt:StudyProduct_a177bffd-41d0-3b50-81c9-05cfc8a63c34|imgt:hasClinicalIndication|imgt:Osteoarthritis_(OA) imgt:River_Vision_Development_Corp|rdfs:label|River Vision Development Corp. _:Bbb8546c0035a3fce9dbf8538c848cee0|imgt:isDecidedBy|imgt:FDA imgt:mAb_814|imgt:inn_proposed_list|118 (2017) imgt:Product_30252648-22d2-3bbf-924d-91ade8b9ddd3|imgt:isProducedBy|imgt:Behringwerke_Aktiengesellschaft imgt:scFv-kappa-heavy-TOXIN_BIG_237|imgt:fused_with| Pseudomonas aeruginosa exotoxin A imgt:Chengdu_Kanghong_Biotech_CoLtd|imgt:produces|imgt:Product_1ee293d6-44ea-3bcb-84c3-b34b51c264d4 imgt:F(ab’)2-Gamma-2_Kappa|rdf:type|imgt:ReceptorType obo:NCIT_C171844|rdf:type|owl:Class imgt:Hanmi_Pharmaceutical|imgt:produces|imgt:Product_a3c9d665-6135-3ace-a49a-560364fbe5be imgt:Construct_690|imgt:isConstructOf|imgt:%5BscFv-nd-nd-PROT%5D2_690 _:B6910f37f2d84e0f3f59a84433aabd2ca|rdf:type|obo:NCIT_C53285 imgt:Agensys|imgt:produces|imgt:Product_438169eb-1ed6-3400-8ca1-cc7d334d5640 imgt:StudyProduct_0f0dd0bb-f4b9-34f4-acf1-c931e5292c31|imgt:application_type|Therapeutic imgt:StudyProduct_a537c635-1641-3b72-aee4-80c8bf5556d3|imgt:development_technology| glutamine synthethase GS Gene Expression System™ imgt:9759|imgt:isImgtStructureEntryOf|imgt:mAb_466 imgt:StudyProduct_75b6a2b5-b839-3dba-a5e9-a51e3ee069fc|imgt:hasClinicalIndication|imgt:Solid_tumors imgt:IgG1-kappa_979|imgt:isMabReceptorOf|imgt:mAb_979 imgt:10557|rdfs:label|10557 imgt:clinical_domain|rdf:type|owl:AnnotationProperty imgt:Segment_754_1|rdf:type|imgt:Segment imgt:StudyProduct_ef4916eb-5a12-3a93-b8b4-b692582617fc|rdf:type|obo:NCIT_C174271 imgt:mAb_394|imgt:hasImgtStructureEntry|imgt:9164 imgt:Heterozygous_familial_hypercholesterolemia_(HeFH)|imgt:isClinicalIndicationOf|imgt:StudyProduct_86467f79-59c4-3fd3-a45f-0318ed52d89f obo:NCIT_C175858|rdf:type|owl:Class imgt:StudyProduct_0fca7506-9287-3470-a77f-f57284843269|imgt:hasDecision|_:B04db4c056d5048ca1f4547c78b9a69f6 imgt:4LLU|rdfs:label|4LLU imgt:Hepatocellular_carcinoma_(HCC)|imgt:isClinicalIndicationOf|imgt:StudyProduct_6609c77d-5c25-3143-a062-e1fd5c12a176 imgt:StudyProduct_ff3ed28b-5382-3602-9a61-d06b879bf722|imgt:hasClinicalIndication|imgt:Psoriasis imgt:IgG4-kappa_1002|imgt:hasConstruct|imgt:Construct_1002 imgt:Product_8f490102-cdea-34aa-b788-031461c9e8b8|imgt:isProducedBy|imgt:GlaxoSmithKline imgt:mAb_924|imgt:hasProduct|imgt:Product_4a23c8ba-9b9e-3cbe-84e7-42b7b0592cc2 imgt:mAb_70|imgt:imgt_note| ME361 (ATCC HB 9325) has isotype gamma 3 (IgG3), a switch variant ME361-S2a (ATCC HB 9326) has isotype gamma 2a (IgG2a) (U.S. Pat. N°4,849,509) imgt:Construct_1030|rdfs:label|Construct_1030 imgt:12120|imgt:isImgtStructureEntryOf|imgt:mAb_1286 imgt:Product_900b5056-b55a-35e7-a10a-bb0aa9603a51|imgt:hasStudyProduct|imgt:StudyProduct_133b632f-0805-34c9-91dc-d9bfcae1944b imgt:mAb_382|imgt:imgt_note| The development of ozoralizumab was discontinued in November 2011 in Phase II by Pfizer Ablynx made a deal with Wyeth for the ATN-103 in November 2006. Wyeth was acquired by Pfizer in 2009. In 2011, Ablynx regained worldwide rights for the ATN-103 Nanobody® is a registered trademark of Ablynx NV. Septembre 2014 - Ablynx signs an exclusive licence agreement with Eddingpharm to develop and commercialise Nanobody®, ozoralizumab (ATN-103) in Mainland China, Hong Kong, Macao and Taiwan (press release) June 2015 - Ablynx signs an exclusive license agreement with Taisho Pharmaceutical Co, Ltd., to develop and commercialise Nanobody® ozoralizumab in Japan (press release) The first VH and the third VH are anti-TNF, the second VH is anti-ALB. 9369 VH [D1] and VH [D3] are anti-TNF humanized Lama glama variable domains, with identical AA sequences. They display Leu L50 (as conventional VH) but have the two features of Lama glama VHH domains which characterize a set of only-heavy-chain antibodies: an hydrophilic anchor in 118 (Arg (R) instead of J-TRP) and a short CDR3-IMGT of 8 AA (CDR-IMGT lengths [8.8.8]). The anti-TNF 9369 VH [D1] and [D3] have 95.7% identity (and 99.1% similarity) with the AA sequence of the anti-TNF Lama glama VHH 3D structure 5m2j_D. They differ by 5 AA changes from 5m2j_D: Q1E, N36D, K95R, L101V and Q123L but have the same CDR3-IMGT. imgt:Innovent_Biologics|imgt:produces|imgt:Product_7206ce92-2c30-3a53-96b4-d2f0bd2f1dd3 imgt:Ebola_virus_infection|imgt:isClinicalIndicationOf|imgt:StudyProduct_d5c67ac7-981f-3c29-bfc0-5cb699da847b imgt:Construct_868|imgt:hasImgtLabel|imgt:staphylococcal_protein_A_(SpA) imgt:Construct_69|rdfs:label|Construct_69 imgt:digoxin|rdf:type|obo:NCIT_C25702 imgt:CD40|skos:definition|CD40 (tumor necrosis factor receptor superfamily member 5, TNFRSF5, p50) imgt:StudyProduct_66280b6a-3ebf-35d4-b22b-a4029f57110c|imgt:application_type|Therapeutic imgt:mAb_869|rdfs:label|mAb_869 obo:NCIT_C152160|rdf:type|owl:Class imgt:B2M|rdf:type|imgt:RPILabel imgt:mAb_393|imgt:hasProduct|imgt:Product_3f761eab-e4ff-3721-a3de-e81704c29f01 _:Bb77217105b4b1494fbeb689cbf82d622|imgt:isDecidedBy|imgt:FDA imgt:Segment_1190_1|imgt:hasImgtLabel|imgt:IgG4-kappa imgt:StudyProduct_c7e49955-619d-39d1-b9be-16105137841f|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:mAb_109|rdfs:label|mAb_109 imgt:Subgroup|rdfs:subClassOf|imgt:CLASSIFICATION imgt:Graft-versus-host_disease_(GvHD)|imgt:isClinicalIndicationOf|imgt:StudyProduct_24d129ce-9321-3ae4-aa1a-93658de71b9e imgt:Segment_582_1|imgt:has_rank|1 imgt:mAb_83|imgt:hasMabReceptor|imgt:IgG1-kappa_83 imgt:Segment_758_1|obo:BFO_0000050|imgt:Construct_758 imgt:Product_6a041710-fe5e-3c9d-b23f-3958785c76ad|imgt:hasStudyProduct|imgt:StudyProduct_9bce41bd-96a7-3675-8cd2-30317439f912 imgt:Eosinophilic_granulomatosis_with_polyangiitis_(EGPA)_formerly_known_as_Churg-Strauss_Syndrome|imgt:isClinicalIndicationOf|imgt:StudyProduct_7af4b43a-36d7-37e8-acbb-5cb820d5d411 imgt:Construct_660|rdfs:label|Construct_660 imgt:mAb_526|imgt:hasProduct|imgt:Product_950458ce-5b79-3a87-87fd-0d76107f13a3 imgt:9144|rdfs:label|9144 imgt:IG-Light-Iota-2-IGI2|imgt:hasChainTypeLevel|imgt:IG-Light-Iota-IGI imgt:StudyProduct_4778a46d-c73d-3a03-9a1f-5b7d0dabf9c3|imgt:isStudyProductOf|imgt:Product_fe170d32-2e79-37f8-b44b-a495e80a927a imgt:Fab-G1-kappa_1169|rdfs:comment|Fab - G1 - kappa imgt:Segment_730_1|rdf:type|imgt:Segment imgt:Product_93e98daf-0377-30bc-900c-0e4a06d486e6|rdf:type|obo:NCIT_C51980 imgt:MH1|rdf:type|imgt:ReceptorType imgt:Construct_220|rdfs:label|Construct_220 imgt:IgG1-kappa-4cys-drug_1274|imgt:hasMolecularComponent|imgt:IG imgt:mAb_139|imgt:imgt_note| Surface granulocyte nonspecific cross-reacting antigen. mAb radiolabelled used in radio-immuno-scintigraphy imgt:Singh_biotechnology|rdfs:label|Singh biotechnology imgt:Construct_1210|rdf:type|imgt:Construct imgt:StudyProduct_bbd57bc5-9f9c-39a5-8a24-1a13ad4e4c85|imgt:hasClinicalIndication|imgt:Multiple_myeloma_(MM) imgt:IgG1-kappa-S239C_2cys-drug_552|rdf:type|imgt:MAbReceptor imgt:StudyProduct_c7e49955-619d-39d1-b9be-16105137841f|imgt:application_type|Therapeutic imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_06e7149d-15e8-3596-a3c5-bf9a81d15c55 imgt:Cancers_breast_ERB2_negative_metastatic|imgt:isClinicalIndicationOf|imgt:StudyProduct_f5b5f2b6-8fd7-38b9-938b-4f838a392b75 imgt:Lymphoma_peripheral_T_cell_(PTCL)|rdfs:label|Lymphoma_peripheral_T_cell_(PTCL) imgt:IgG1-kappa_497|imgt:hasConstruct|imgt:Construct_497 imgt:mAb_199|rdf:type|imgt:INN imgt:StudyProduct_3d3b1b00-4296-3c01-9e34-6a5b725dbe90|rdfs:label|StudyProduct_3d3b1b00-4296-3c01-9e34-6a5b725dbe90 imgt:mAb_151|imgt:hasProduct|imgt:Product_ee63dd0e-c659-3edb-b9e8-728ccca5e064 imgt:IgG1-kappa_1279|rdfs:comment|IgG1 - kappa imgt:Construct_688|imgt:isConstructOf|imgt:ENZ_1DOMAIN_688 imgt:half-G1-kappa_scFv-HEAVY-LAMBDA-h-CH2-CH3_919|imgt:hasConstruct|imgt:Construct_919 imgt:Product_d3f3fc46-b4d3-3454-a1c7-97eae9e1a634|imgt:commun_name|F(ab’)2 4D5-8/UCHT1-v1 imgt:Product_bd0c88b6-9625-38c8-87d1-1890eee03a40|rdf:type|obo:NCIT_C51980 imgt:StudyProduct_38beca1b-e357-396b-9768-19337fce60ec|imgt:hasClinicalIndication|imgt:GE_Junction_Cancer imgt:11336|rdf:type|obo:NCIT_C25402 imgt:11969|rdfs:label|11969 imgt:LINKER|rdf:type|imgt:SequenceLabels imgt:Product_e5ca6245-7a11-3390-b7de-6b5e8870b2ab|imgt:hasStudyProduct|imgt:StudyProduct_dbd5a879-91a6-3fef-8a6a-6eb4819f1066 imgt:Psoriasis|imgt:isClinicalIndicationOf|imgt:StudyProduct_0f7055d8-c758-3097-87c0-4548bbf4491a imgt:adenocarcinoma_antigen|rdf:type|obo:NCIT_C25702 imgt:mAb_820|imgt:clinical_trials|11 studies found, 4 recruiting obo:NCIT_C170090|rdf:type|owl:Class imgt:Segment_423_1|imgt:has_rank|1 imgt:StudyProduct_975147d2-18cf-3edc-a992-c8e1071edb6c|rdf:type|obo:NCIT_C174271 imgt:Construct_775|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Celltrion_Inc|rdf:type|obo:NCIT_C54131 imgt:StudyProduct_165a82e1-b3b3-3d74-8e9b-63f471a1f450|imgt:application_type|Therapeutic imgt:Gene|owl:disjointWith|imgt:Allele imgt:Construct_367|rdfs:label|Construct_367 imgt:Product_00890ef7-c752-3fa4-98ed-dcfff088e354|rdf:type|obo:NCIT_C51980 imgt:StudyProduct_7c989237-1897-3d9b-bf0d-13cbd5682ac7|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:Segment_650_1|obo:BFO_0000050|imgt:Construct_650 imgt:TNFRSF1A|skos:definition|Chain or receptor comprising TNFRSF1A imgt:mAb_797|imgt:clinical_trials|11 studies found, 6 recruiting imgt:mAb_1040|imgt:hasImgtStructureEntry|imgt:11331 imgt:IgG1-kappa_1110|rdf:type|imgt:MAbReceptor obo:NCIT_C120556|rdfs:subClassOf|obo:NCIT_C1909 imgt:IGEngineeredLabel|rdfs:label|IGEngineeredLabel imgt:Segment_875_1|imgt:has_rank|1 imgt:Product_bebc2f14-8f71-3ea6-8a19-cbba5d49a3c8|imgt:commun_name|ARGX-113 imgt:Construct_291|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:mAb_986|imgt:clinical_trials|1 studies found, 1 recruiting imgt:StudyProduct_51ff04a9-18a5-33e6-b557-c38f878f45b7|imgt:isStudyProductOf|imgt:Product_eee3061f-bf14-3e3d-9646-c7c2fe6d3166 imgt:Product_6bc98c9a-0b0b-3b1e-a407-ec0e4a4c2c92|imgt:commun_name|GS-5745 imgt:TR-ALPHA_BETA-2|rdf:type|imgt:ChainLabels imgt:StudyProduct_cd05fc1e-523d-37e9-acc4-bf06c8ea5473|imgt:hasClinicalIndication|imgt:Staphylococcal_sepsis_in_infants_with_low_birth_weight imgt:mAb_1213|imgt:inn_number|11961 imgt:Segment_820_1|obo:BFO_0000050|imgt:Construct_820 imgt:mAb_1229|imgt:hasProduct|imgt:Product_ca9d88fe-1dc4-3b2a-be85-2dc4640a46d0 imgt:CPCA_PROTEIN-PEG-FC_613|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/CPCA_PROTEIN-PEG-FC.png imgt:StudyProduct_58672d44-3c70-3397-842c-70fe8a5d6b98|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_fc5cc4ff-cd79-3360-ba2c-9cb8a2518a23|rdf:type|obo:NCIT_C174271 imgt:mAb_1073|imgt:inn_proposed_list|123 (2020) imgt:Construct_1075|imgt:hasImgtLabel|imgt:half-IG_G1-kappa/(scFv-kappa-heavy)-h-CH2-CH3 imgt:IgG1-kappa_1033|rdf:type|imgt:MAbReceptor imgt:Product_233bf28c-d31a-32fb-b8ed-8ca698c7c213|imgt:commun_name|LDP imgt:mAb_565|rdf:type|imgt:INN imgt:_COS_cells_transient_expression|imgt:isExpressionSystemOf|imgt:StudyProduct_effa3831-1319-3a49-852d-d5eef1587a6e imgt:IgG1-kappa_MM_508|rdfs:comment|IgG1-kappa_MM imgt:IgG1-kappa_453|obo:RO_0002162|imgt:Hum imgt:Product_73163992-bca3-3133-8e3d-bb21f7359d0d|imgt:isProducedBy|imgt:APEIRON_Biologics_AG imgt:StudyProduct_62951ba3-dd15-399d-83b1-70765965f754|imgt:application_type|Therapeutic imgt:scFv-kappa-heavy_1132|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/scFv-kappa-heavy.png imgt:mAb_486|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=486 imgt:Janssen_Pharmaceuticals_inc|rdfs:label|Janssen Pharmaceuticals, inc. imgt:Solid_tumors|imgt:isClinicalIndicationOf|imgt:StudyProduct_1ae0fb86-4724-36d8-84b2-697385005f0c imgt:mAb_768|imgt:hasMabReceptor|imgt:IgG1-kappa_768 imgt:mAb_605|imgt:inn_recommended_list|76 (2016) imgt:Construct_966|rdfs:label|Construct_966 imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_0baedbe6-1604-34c0-94ab-a794447ae333 imgt:Segment_976_1|imgt:hasImgtLabel|imgt:IgG1-kappa _:B9982431bccc367c01fee5a2c99ec0586|rdf:type|obo:NCIT_C53285 obo:NCIT_C170106|rdf:type|owl:Class imgt:StudyProduct_f4c6b23a-506f-3b37-be20-32b17c3bfc58|imgt:hasExpressionSystem|imgt:_E.coli_(Escherichia_coli) imgt:StudyProduct_037a290c-5cd1-3f09-b298-2d6e639875bc|rdfs:label|StudyProduct_037a290c-5cd1-3f09-b298-2d6e639875bc imgt:Segment_1185_1|rdf:type|imgt:Segment imgt:IL21R|imgt:isTargetOf|imgt:IgG1-lambda-PROTEIN_1296 imgt:amgevita™|rdfs:comment| AMGEVITA™ (adalimumab ABP 501) developed by Amgen (Thousand Oaks CA USA) approved in the EU by EC on March 22 2017 for multiple inflammatory diseases.EMEA/H/C/004212 press release Same clinical indications as HUMIRA®. imgt:Staphylococcal_sepsis_in_infants_with_low_birth_weight|imgt:clinical_domain|Infectiology imgt:Product_c9b09440-3c97-37f9-a7a3-a051cfd3499c|imgt:hasStudyProduct|imgt:StudyProduct_e98c2bee-e41e-31b4-bedf-7b531366ad96 imgt:IGHG1_Fc_(Fragment_constant)-%5BIL2_(interleukin_2_IL-2)%5D2|rdfs:label|IGHG1 Fc (Fragment constant) - [IL2 (interleukin 2, IL-2)]2 imgt:Product_03bd8656-46d5-3883-867e-29737a9f2afe|rdf:type|obo:NCIT_C51980 imgt:mAb_531|imgt:hasImgtStructureEntry|imgt:10018 imgt:10873|rdf:type|obo:NCIT_C25402 imgt:Construct_691|rdfs:label|Construct_691 imgt:StudyProduct_1bceaf82-dddc-3f9d-8b7d-91658f1f9533|rdfs:label|StudyProduct_1bceaf82-dddc-3f9d-8b7d-91658f1f9533 imgt:Segment_476_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:StudyProduct_d234256b-ab49-3a01-95d9-b79cd3fb3168|imgt:development_technology| Cambridge Antibody Technology (CAT) human antibody phage display library Antibody phage display imgt:StudyProduct_bf101d12-c918-343a-af15-691a79ed2bb6|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_7462810f-06e4-374a-a7c3-d024d5d63e0d|rdfs:label|StudyProduct_7462810f-06e4-374a-a7c3-d024d5d63e0d imgt:IgG1-nd_280|imgt:hasConstruct|imgt:Construct_280 _:B222f2635222a29acfd30eb4eb5980313|imgt:hasStatut|imgt:approval imgt:AMHR2|rdfs:label|AMHR2 imgt:IgG1-kappa_172|imgt:hasMolecularComponent|imgt:IG imgt:IgG1-kappa-S239C_2cys-drug_552|http://semanticscience.org/resource/SIO_000291|imgt:CD33 imgt:StudyProduct_bfa4c5bc-f925-34a6-aca5-541ba43c3b76|imgt:development_technology| Medarex’s UltiMAb® imgt:Construct_1200|rdf:type|imgt:Construct imgt:Solid_tumors_advanced_or_metastatic|imgt:isClinicalIndicationOf|imgt:StudyProduct_6a3d73b1-d98e-3a7a-a499-079a203ad53f imgt:GPRC5D|obo:RO_0002162|imgt:Homsap imgt:ImClone_Systems_Inc|imgt:produces|imgt:Product_d80bdb56-4a05-3d99-ab25-22438984eabb imgt:Kodiak_Sciences_USA|imgt:produces|imgt:Product_714a4643-f043-3984-9431-848da1cf2746 imgt:StudyProduct_877034ef-cdfa-3d6f-a36c-87e6faef79ca|imgt:isStudyProductOf|imgt:Product_0d23f5a7-b8cb-3eb8-ba07-41a57852fdf3 imgt:Construct_155|obo:BFO_0000051|imgt:Segment_155_1 imgt:mAb_522|imgt:hasImgtStructureEntry|imgt:10835 _:Bac73f483139a4bd1406ebb7dd7b12dda|dc:date|2017-02-22 imgt:Segment_447_1|rdf:type|imgt:Segment _:Bb6cf9db1a63b7ae68d78f77897e14173|imgt:isDecidedBy|imgt:FDA imgt:mAb_680|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=680 imgt:StudyProduct_80a12eef-78f8-319c-9b8b-3bc915c82956|imgt:hasClinicalIndication|imgt:Neoplasms imgt:StudyProduct_3ddaf22c-92f7-3eaa-9933-8dc274f0f92e|imgt:application_type|Therapeutic imgt:Construct_457|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:mAb_1158|imgt:inn_number|11588 imgt:IgG4-kappa_942|rdfs:comment|IgG4 - kappa imgt:10558|rdfs:label|10558 imgt:IgG1-kappa_417|rdfs:comment|IgG1 - kappa imgt:StudyProduct_f9f1975b-f872-369b-b5c9-e8cf58241df8|imgt:isStudyProductOf|imgt:Product_df096a2e-9ca2-34c9-b918-135310033876 imgt:INTEGRIN-ALPHA-1|rdf:type|imgt:ChainLabels imgt:mAb_1283|imgt:inn_proposed_list|126 (2022) imgt:Product_98a40d96-4f45-305e-ab3e-b032a15f3eef|rdf:type|obo:NCIT_C51980 imgt:CEACAM5|imgt:isTargetOf|imgt:IgG1-kappa_1086 imgt:FC-GAMMA-2C|skos:definition|Fc comprising the CH2-CH3 domains from two H-GAMMA-2C chains imgt:9940|imgt:isImgtStructureEntryOf|imgt:mAb_499 imgt:mAb_149|imgt:hasMabReceptor|imgt:IgG1-kappa_149 imgt:TR-Gamma-3_Delta|rdf:type|imgt:ReceptorType imgt:StudyProduct_1fd5cdac-9470-3ccd-b72e-92d15d0578c1|imgt:hasDecision|_:B531ab3cce7a1d139d6f28312456d7767 imgt:StudyProduct_f9fa0669-8698-340e-bafc-63560de1d7cf|imgt:isStudyProductOf|imgt:Product_09c862c7-fb75-303d-94b6-542f658ababc imgt:Product_8bead6f3-5fc0-3c25-b25a-77c4cf2d64be|imgt:isProductOf|imgt:mAb_1264 imgt:Segment_169_1|rdf:type|imgt:Segment imgt:VH_734|http://semanticscience.org/resource/SIO_000291|imgt:CCR4 obo:NCIT_C74006|rdfs:subClassOf|obo:NCIT_C1909 imgt:Product_75f31599-7147-3250-906f-28fba39a311c|imgt:commun_name|risankizumab-rzaa imgt:Graft-versus-host_disease_(GvHD)|imgt:isClinicalIndicationOf|imgt:StudyProduct_840fc260-3eb1-31df-a157-7005ef62b2ae imgt:9158|imgt:isImgtStructureEntryOf|imgt:mAb_174 imgt:1C-LIKE-RPI-MH1Like|rdfs:label|1C-LIKE-RPI-MH1Like imgt:mAb_659|imgt:inn_recommended_list|77 (2017) imgt:Segment_482_1|rdf:type|imgt:Segment imgt:StudyProduct_ec44632e-85a9-3925-a446-75a4f03602f3|rdf:type|obo:NCIT_C174271 imgt:mAb_1000|imgt:hasImgtStructureEntry|imgt:11301 imgt:mAb_207|imgt:hasProduct|imgt:Product_d51c7a19-f660-3ffb-8ce3-c176dfe0b4d7 imgt:Product_dbe05b64-0640-322a-811c-7c37fcafe09b|imgt:isProductOf|imgt:mAb_962 imgt:Product_f585c3aa-a22a-3afb-9114-31450ab8bf8e|rdf:type|obo:NCIT_C51980 imgt:PACT_Pharma_Inc|rdfs:comment|South San Francisco , USA imgt:Non-Hodgkin's_lymphoma_(NHL)|imgt:isClinicalIndicationOf|imgt:StudyProduct_cf211e0b-6a75-3b78-919e-27956a3554aa imgt:Product_97984f90-666b-3255-b4ca-53dfa6fe9b05|imgt:commun_name|CDA 1 imgt:OncoMed_Pharmaceuticals|imgt:produces|imgt:Product_8fd209ba-cc8f-3fab-aac7-df9d420e83e2 imgt:StudyProduct_000fefbd-8616-3e3d-aa5c-29ce1a6e2aad|imgt:hasClinicalPhase|imgt:Phase_I/II imgt:mAb_1097|imgt:inn_recommended_list|85 (2021) imgt:Construct_934|obo:BFO_0000051|imgt:Segment_934_1 imgt:StudyProduct_af9be6be-ea5b-33ab-9ae0-3a9e93b1c12e|imgt:application_type|Therapeutic imgt:Product_d3c711cd-8848-34a6-85be-a70321305cd0|rdf:type|obo:NCIT_C51980 imgt:IgG1-kappa_350|imgt:hasConstruct|imgt:Construct_350 imgt:Product_1e3cda94-2406-3561-8738-08bd95e9c60b|imgt:hasStudyProduct|imgt:StudyProduct_c05017c9-5a97-3053-981e-7f852cffae8d imgt:mAb_447|imgt:imgt_note| Carole Lefranc, Angèle Marcel and Marie Gineste M. Innovation thérapeutique et traitement de l’hémophilie. Therapeutic innovation in the treatment of haemophilia Dossier Les maladies hémorragiques. La revue de l’infirmière, 68 (253), 26-27 (2019) doi : 10.1016/j.revinf.2019.06.006 (in French) _:Ba99aea26187015f3fd5d93c37bc24e64|imgt:hasStatut|imgt:approval imgt:Rheumatoid_arthritis_(RA)|imgt:isClinicalIndicationOf|imgt:StudyProduct_b589dcfe-a395-3d62-b63b-52ab31b07cc3 imgt:StudyProduct_5aa11d1a-782e-3627-a8c5-445add6c9852|rdfs:label|StudyProduct_5aa11d1a-782e-3627-a8c5-445add6c9852 imgt:mAb_1011|imgt:inn_proposed_list|122 (2019) obo:NCIT_C133543|rdfs:subClassOf|obo:NCIT_C1909 _:Bcd50bb786e7f6611279b1b309fe2613b|imgt:hasDesignation|imgt:Orphan_drug imgt:IgG2a-nd_159|http://semanticscience.org/resource/SIO_000291|imgt:HLA-DR10 imgt:V-J-gene|rdfs:label|V-J-gene imgt:IgA-nd_121|rdfs:comment|IgA - nd imgt:Product_37d8c4e2-9f50-3ca5-bcfe-d2357ba209e5|imgt:commun_name|E6040 imgt:Solid_tumors|imgt:isClinicalIndicationOf|imgt:StudyProduct_8889d288-1776-3c68-a627-317a34dc1c95 imgt:gDNA|skos:definition|Identifies genomic DNA, a nucleotide sequence made of A, T, C, G, obtained from a genome, or by extension, synthetic DNA having the characteristics of genomic DNA. imgt:mAb_1049|imgt:inn_number|11274 imgt:mAb_646|imgt:hasOriginClone|imgt:Clone_646 imgt:StudyProduct_fd29fe6c-dc18-3851-a09b-b0e6a16e6e45|imgt:application_type|Therapeutic _:Bc5619f02cc9a6d43631d85a0535476ab|dc:date|1993-06-01 imgt:Segment_225_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Pseudomonas_aeruginosa_exotoxin_A|rdf:type|imgt:SegmentLabels imgt:Clone_963|imgt:clone_name|CXA1a-CB-CC1-TR1- MPP5-C60 imgt:FPIA_%5BPROTEIN%5D2-FC_tridissulfide_1294|rdfs:label|FPIA_[PROTEIN]2-FC_tridissulfide_1294 imgt:Product_5bdd4781-1f7e-3d2a-a7f9-bebb5a59b8db|imgt:hasStudyProduct|imgt:StudyProduct_d76e18ea-00be-3b61-9daa-04b219b160a5 imgt:mAb_530|imgt:inn_recommended_list|76 (2016) imgt:StudyProduct_f858568c-74da-3ed4-8de8-a2126be8b033|rdf:type|obo:NCIT_C174271 imgt:IgG4-nd_748|http://semanticscience.org/resource/SIO_000291|imgt:CD3E imgt:StudyProduct_68144c19-458d-3c01-9bee-0b7e962fcf44|rdfs:label|StudyProduct_68144c19-458d-3c01-9bee-0b7e962fcf44 imgt:StudyProduct_6c4310e8-5853-3fa6-aeb2-9abd5f0abf91|imgt:hasClinicalPhase|imgt:Phase_I imgt:StudyProduct_454fa2ab-d4ad-3680-9760-9da2d95eb36a|imgt:isStudyProductOf|imgt:Product_537aaf49-2c7a-3981-8bd7-5b72ab2e0fb9 imgt:cyltezo™|rdfs:label|CYLTEZO™ imgt:Product_48254897-faf9-3351-a974-a0f1aae477e6|imgt:isProducedBy|imgt:Seattle_genetics_Inc imgt:Product_19035bc7-8361-3721-af18-5bc56c99124d|imgt:isProductOf|imgt:mAb_916 imgt:Construct_565|imgt:isConstructOf|imgt:IgG2-kappa-4cys-drug_565 imgt:StudyProduct_50ee47ba-842f-362d-a090-229570dec725|imgt:application_type|Therapeutic imgt:Product_d1ff3524-abf9-3a7a-93d3-8b514c80da83|imgt:comercial_name|VIRTRON imgt:4LLW|rdfs:label|4LLW imgt:StudyProduct_b87ee559-aea6-37ce-82b5-a1c9e1c007a2|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:MAbReceptor_15|obo:RO_0002162|imgt:Hum obo:NCIT_C82414|rdfs:subClassOf|obo:NCIT_C1909 imgt:Product_b874e91f-5c72-30ea-8bd2-f0bf2e6cc591|imgt:commun_name|INX-021 imgt:Segment_698_1|imgt:has_rank|1 imgt:Cancers_gastric|imgt:isClinicalIndicationOf|imgt:StudyProduct_f5092849-0ebd-38bc-ba9d-4ad61b927f88 imgt:StudyProduct_23d499a1-37f8-3d63-8353-5f1f7e4a7e91|imgt:isStudyProductOf|imgt:Product_64d31d25-899a-3941-a5d0-bc3b3c0b468b imgt:mAb_1185|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=1185 imgt:Genentech_Inc|imgt:produces|imgt:Product_f54c6043-6277-3c37-b202-92f1deb4aaff imgt:Segment_302_1|obo:BFO_0000050|imgt:Construct_302 imgt:mAb_1237|rdf:type|obo:NCIT_C1909 imgt:mAb_1013|imgt:imgt_note| tifcemalimab INN name is the one amended in PL124 (2020) (in replacement of icatolimab (PL122)). imgt:mAb_1152|imgt:inn_recommended_list|86 (2021) imgt:Product_bfe41bf2-718f-3803-b385-cfc07fd9645d|imgt:hasStudyProduct|imgt:StudyProduct_9894751f-b03c-3da4-b7bd-384a3acaa1a0 imgt:Segment_395_3|imgt:has_rank|3 imgt:Product_70626d7d-afcd-3d0c-944a-b65990e20e32|imgt:isProductOf|imgt:mAb_184 imgt:9475|rdf:type|obo:NCIT_C25402 imgt:mAb_91|imgt:hasBibliographicReference|pubmed:9140729 imgt:TITIN|rdfs:label|TITIN imgt:mAb_440|imgt:clinical_trials|1326 studies found, 74 recruiting imgt:Anemia_associated_with_chronic_renal_failure|rdf:type|obo:NCIT_C185637 imgt:mAb_308|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=308 imgt:Segment_1257_1|rdf:type|imgt:Segment imgt:Product_01a1bc2c-213a-3e68-b062-36ba9d5d7cd7|imgt:isProducedBy|imgt:MorphoSys imgt:TR-BETA|rdf:type|imgt:ChainLabels imgt:StudyProduct_8a6affb8-2186-34a2-89d8-78314af8f13c|imgt:hasDecision|_:Bd89782b614a486dadde5378c843db477 imgt:FUSION-%5BTNFRSF1A%5D2-FC-GAMMA-1|skos:definition|Fusion protein for immune application (FPIA) comprising TNFRSF1A fused with immunoglobulin G1 FC fragment imgt:StudyProduct_4e6bde7e-d321-3797-854b-8b18ca0ae17f|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:mAb_1034|imgt:hasMabReceptor|imgt:IgG4-kappa_1034 imgt:mAb_1162|imgt:hasMabReceptor|imgt:FPIA_%5BPROTEIN%5D2-FC_1162 imgt:Product_ce822f79-054d-3661-8bf4-37f73f52daa5|imgt:comercial_name|CINQAERO® imgt:StudyProduct_4e0694fb-ee8d-3a3e-8aff-728d410b3829|imgt:application_type|Therapeutic imgt:IgG2-kappa_561|obo:RO_0002162|imgt:Homsap imgt:StudyProduct_4cfdf2ec-f342-3054-9bde-f57fcde70b5d|imgt:hasClinicalPhase|imgt:Phase_III imgt:StudyProduct_bbf45e5e-377b-3639-b622-b079804455bc|imgt:development_technology| Human hybridoma Sugar-Engineered Antibody (SEA) technology imgt:IgG4-kappa_548|obo:RO_0002162|imgt:Hum imgt:StudyProduct_7a34b138-251b-35be-8436-2c6dc1728af2|imgt:hasClinicalIndication|imgt:Mesothelioma_malignant imgt:Product_5021057f-cae7-3bd7-9a40-1a3c99bf3ca5|imgt:isProducedBy|imgt:OncoTherapy_Science_Inc obo:NCIT_C118674|rdfs:subClassOf|obo:NCIT_C1909 imgt:Product_e2daa81e-b7fa-3753-b5d4-5d9ac0cacb3e|rdfs:label|Product_e2daa81e-b7fa-3753-b5d4-5d9ac0cacb3e imgt:Segment_611_2|imgt:hasImgtLabel|imgt:IGHG1 imgt:mAb_219|imgt:imgt_note| Hybrid: A hybrid antibody is one in which one-half of the antibody (one heavy chain and one light chain) is from one species origin whereas the other half is from another species origin. br /An hybrid antibody is identified by a pre-stem made of each species pre-stem separated by the letter 'x' in the INN. For example, a rat-murine hybrid antibody is identified by the pre-stem b-axo-/b. imgt:Janssen_Biotech_Inc|rdfs:comment|Horsham , USA imgt:CH2-CH3|skos:definition|C-DOMAIN corresponding to the CH2-CH3 exon coding region imgt:Solid_tumors|imgt:isClinicalIndicationOf|imgt:StudyProduct_f1733385-f48e-3542-924d-e9a8745a14c7 imgt:StudyProduct_d17f568c-2f95-3814-9c7b-159fefc500e3|imgt:isStudyProductOf|imgt:Product_70626d7d-afcd-3d0c-944a-b65990e20e32 imgt:mAb_1102|rdf:type|obo:NCIT_C158558 imgt:Product_e634066b-75e5-3068-b644-7307d78fe47c|imgt:hasStudyProduct|imgt:StudyProduct_404d3f0c-1c9b-3bd2-adb9-d5a56ca3deb8 imgt:IgG1-kappa_1185|rdfs:comment|IgG1 - kappa imgt:StudyProduct_dbd9c39c-f335-3893-9973-0b460a8f03fa|rdf:type|obo:NCIT_C174271 imgt:Segment_104_1|imgt:hasImgtLabel|imgt:IgG1-nd imgt:9821|rdf:type|obo:NCIT_C25402 imgt:_Sp2/0_mouse_hybridoma_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_06f7f86b-9caf-3c74-88da-482672c16dbf imgt:MolecularComponent|protege:protege#subclassesDisjoint|true imgt:10347|imgt:isImgtStructureEntryOf|imgt:mAb_651 imgt:StudyProduct_eba83d89-9fc8-31a7-9337-0a034a6a47cd|imgt:application_type|Therapeutic _:B76deaa84a86ba9a1fa74fcd78849e1aa|imgt:isDecidedBy|imgt:Japan_(MHLW) imgt:PROTEIN_2DOMAINS_2F_278|rdf:type|imgt:MAbReceptor imgt:mAb_832|imgt:imgt_note| WHO Drug Information, Vol. 34, No. 3, 2020. Proposed INN List 124 – COVID-19 (special edition) (9 October 2020) pages 642-669. Proposed INN List 124 (19 December 2020, published on 22 January 2021) pages 929-1102. imgt:StudyProduct_76ee9841-a655-331c-a8ef-8ffe48ebe5fc|imgt:application_type|Therapeutic _:Bb8f3a2e470a0fc74a161df00dcda8d18|rdf:type|obo:NCIT_C53285 imgt:StudyProduct_bc948b67-2463-3ad7-990e-7a42c8101991|imgt:hasClinicalIndication|imgt:Cancers_non-small_cell_lung_(NSCLC) imgt:StudyProduct_551ac7e6-d7c1-3505-a362-a731b13d1d19|imgt:hasClinicalIndication|imgt:Inflammatory_diseases imgt:H-ALPHA-2|skos:definition|Ig-Heavy-Alpha-2 chain comprising VH, CH1, H-CH2, CH3 and CHS domains imgt:Product_e055a0d3-71ff-3d4e-ad35-050d316b88bd|imgt:isProducedBy|imgt:Horizon_Therapeutics_plc imgt:mAb_397|imgt:hasMabReceptor|imgt:PEPTIDE-PEPTIDE-CARRIER_BIG_397 imgt:10010|imgt:isImgtStructureEntryOf|imgt:mAb_528 imgt:StudyProduct_000d9344-d46a-342c-8fb9-78ce3db80369|imgt:hasClinicalPhase|imgt:Phase_I imgt:mAb_387|imgt:inn_recommended_list|67 (2012) _:B856adb8d63029e0d1e41d853bd87d5f4|rdf:type|obo:NCIT_C53285 imgt:Product_f6eddd34-803e-38c4-988e-4fdccd05fd3b|imgt:isProducedBy|imgt:Amgen imgt:Product_51d4c376-f2c0-341a-bd4d-be7c150e0bcf|imgt:isProducedBy|imgt:Bristol-Myers_Squibb imgt:mAb_1151|imgt:inn_proposed_list|124 (2020) imgt:Cancers_colorectal_(CRC)|imgt:isClinicalIndicationOf|imgt:StudyProduct_6df32054-85ca-320b-821e-1aaa146ca94c imgt:mAb_866|imgt:inn_name|rolinsatamab talirine imgt:ACE2_(Pr18-805)|skos:definition|Angiotensin-converting enzyme 2 imgt:Segment_254_1|imgt:hasImgtLabel|imgt:IgG1-nd imgt:Segment_586_1|rdfs:label|Segment_586_1 imgt:LRRC15|imgt:isTargetOf|imgt:IgG1-kappa_816 imgt:Product_a485a257-0ee7-3b5b-836e-05670bd746d8|rdfs:label|Product_a485a257-0ee7-3b5b-836e-05670bd746d8 imgt:IgG1-kappa-4F-drug_1259|http://semanticscience.org/resource/SIO_000291|imgt:TNFRSF17 imgt:Segment_1024_1|rdfs:label|Segment_1024_1 imgt:IgG4-kappa_1218|rdfs:label|IgG4-kappa_1218 imgt:StudyProduct_3c35d54e-9820-3ddb-b28e-140f4b7edbdc|imgt:hasClinicalIndication|imgt:Type_2_diabetes_(T2_DM) imgt:mAb_925|imgt:inn_recommended_list|82 (2019) imgt:ERBB2|imgt:isTargetOf|imgt:IgG1-kappa-4cys-drug4_1278 imgt:Segment_1284_1|rdf:type|imgt:Segment pubmed:7682986|dc:contributor|Price MR imgt:Product_604eb9aa-3e35-3cd6-8a61-bf5cb25c6749|rdf:type|obo:NCIT_C51980 imgt:Segment_494_1|rdfs:label|Segment_494_1 imgt:IgG2-kappa_1144|imgt:isMabReceptorOf|imgt:mAb_1144 imgt:9735|imgt:isImgtStructureEntryOf|imgt:mAb_613 obo:SO_0000340|owl:disjointWith|obo:NCIT_C103167 _:B2ec2909e8fc9de28ee640e6956657a7b|imgt:isDecisionOf|imgt:StudyProduct_b35e865b-2d30-3d21-8b19-f6b43d138be5 imgt:MH2|rdf:type|imgt:ReceptorLevelChainType imgt:IG-Heavy-Tau|rdf:type|imgt:ClassLevelChainType imgt:secreted|rdf:type|imgt:Molecule_StructureType imgt:Segment_324_1|rdf:type|imgt:Segment imgt:StudyProduct_c32ff34d-399e-3f3d-8ee3-8e8c565ef2cf|rdfs:label|StudyProduct_c32ff34d-399e-3f3d-8ee3-8e8c565ef2cf imgt:mAb_519|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=519 imgt:StudyProduct_9bcf8445-4aa4-3747-8ef4-f74657af2926|rdf:type|obo:NCIT_C174271 imgt:Product_49d0e51d-fc17-3c61-be0a-87eb08d806f8|imgt:isProductOf|imgt:mAb_621 imgt:Product_560b3af6-c040-3e31-9e9f-a1da206fbe84|rdf:type|obo:NCIT_C51980 imgt:mAb_1113|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=1113 imgt:Segment_288_2|obo:BFO_0000050|imgt:Construct_288 imgt:Product_b902d379-45ba-3460-955c-938cf82600f1|imgt:isProducedBy|imgt:Eisai_Co_Ltd imgt:FPIA_%5BFC-%5BPEPTIDE-PROTEIN%5D2%5D3_998|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/FPIA_[FC-[PEPTIDE-PROTEIN]2]3.png imgt:Product_2237e67f-cb5f-3101-bed8-f9eee1ebb81c|rdfs:label|Product_2237e67f-cb5f-3101-bed8-f9eee1ebb81c imgt:Product_846d926a-eaf9-39c4-851c-26956cdc70bd|imgt:hasStudyProduct|imgt:StudyProduct_61a30a33-9767-352a-9a08-87a31caba00d imgt:StudyProduct_4adb7627-2f8a-3ff1-97fd-04fe49ec7aaf|rdf:type|obo:NCIT_C174271 https://doi.org/10.1038/332323a0|rdfs:label|https://doi.org/10.1038/332323a0 imgt:mAb_1062|imgt:hasImgtStructureEntry|imgt:11348 obo:NCIT_C174792|rdf:type|owl:Class imgt:mAb_1080|rdfs:label|mAb_1080 imgt:Product_89f1ae82-3fb5-3b22-b31b-63474999c711|imgt:commun_name|LAPS-Exendin-4 imgt:XTL_Biopharmaceuticals|rdfs:comment|Herzliya , Israel imgt:Product_65f1a583-9ab6-38d8-8b26-1a11dfa24b99|imgt:comercial_name|ZINBRYTA™ (daclizumab high-yield process) imgt:1FGV|rdf:type|obo:NCIT_C25402 imgt:4G6K|rdf:type|obo:NCIT_C25402 imgt:StudyProduct_a71a1285-29dd-3fe7-b859-8d284798767e|rdfs:label|StudyProduct_a71a1285-29dd-3fe7-b859-8d284798767e imgt:mAb_182|imgt:inn_number|7882 imgt:CD3E|imgt:isTargetOf|imgt:MAbReceptor_99 imgt:mAb_902|imgt:imgt_note| There is one amino acid difference between the H chain of 10409 losatuxizumab (10342 losatuxizumab vedotin) CH2 S3 (238) and 10960 serclutamab (10959 serclutamab talirine) due to a site-specific drug attachment engineered cysteine CH2 C3 (238) in 10960 (conjugated in 10959).There are four amino acid differences (two in the VH and two linked to allotypes) between the H chain of of 10409 losatuxizumab (10342 losatuxizumab vedotin) VH R (31), S (100), CH3 E12 (355), M14 (357) and 10262 depatuxizumab (10263 depatuxizumab mafodotin) VH S (31), G (100), CH3 D12 (355), L14 (357).The amino acid sequence of the kappa chain (1-214 AA) is identical in 10262, 10263, 10342, 10409, 10959 and 10960. imgt:mAb_184|imgt:hasProduct|imgt:Product_70626d7d-afcd-3d0c-944a-b65990e20e32 imgt:mAb_511|rdf:type|obo:NCIT_C1909 imgt:Construct_582|imgt:isConstructOf|imgt:FPIA_%5BPROTEIN%5D2-FC_582 obo:NCIT_C169932|rdf:type|owl:Class imgt:_E.coli_(Escherichia_coli)|imgt:isExpressionSystemOf|imgt:StudyProduct_8fa3f462-191c-3a82-aa98-661aad76974e imgt:Crohn's_disease_(CD)|imgt:isClinicalIndicationOf|imgt:StudyProduct_ab13fb55-fae8-3e46-a937-1cafd1d76ce6 imgt:StudyProduct_a186afa2-4718-3a82-81f9-640ec7c1cc30|imgt:isStudyProductOf|imgt:Product_188975ba-e8fc-3ccd-8368-e47522abda48 imgt:Cancers_non-small_cell_lung_(NSCLC)|imgt:isClinicalIndicationOf|imgt:StudyProduct_fa674a2c-d774-3752-b862-456fe00e4a76 imgt:StudyProduct_e6fe1e0b-d794-30a4-9c92-0a5f8a391919|imgt:hasClinicalPhase|imgt:Phase_II imgt:Construct_96|rdf:type|imgt:Construct imgt:Multiple_sclerosis_(MS)|imgt:isClinicalIndicationOf|imgt:StudyProduct_2afc056f-f82d-38cf-8be5-284f8ce96916 imgt:Product_ae26fe5d-0957-3750-9fd4-e84dc4303b03|rdfs:label|Product_ae26fe5d-0957-3750-9fd4-e84dc4303b03 imgt:IgG1-kappa_832|http://semanticscience.org/resource/SIO_000291|imgt:SIGLEC8 imgt:Staphylococcal_infections|rdf:type|obo:NCIT_C185637 imgt:Glioblastoma|imgt:isClinicalIndicationOf|imgt:StudyProduct_7027cb45-d588-3eb7-b1c2-d35ec6045bee imgt:Construct_925|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Construct_411|imgt:hasImgtLabel|imgt:IgG1-kappa _:B20b13201cf0b01499db0bf981d116d44|imgt:isDecisionOf|imgt:StudyProduct_726eb992-d90b-3011-a039-684b92d092e8 imgt:Segment_1157_1|obo:BFO_0000050|imgt:Construct_1157 imgt:Product_3f09e6a8-dad0-3689-9e50-6e9dbb7a5805|imgt:commun_name|eptinezumab-jjmr _:Bf2d472bcff88b4db21dadec08d516dac|rdf:type|obo:NCIT_C53285 imgt:StudyProduct_11ccf5f8-b5db-36fd-b9b4-9e072257a5f4|rdf:type|obo:NCIT_C174271 imgt:Product_cef966d9-7220-3c3b-8d4c-3695c4e55488|imgt:hasStudyProduct|imgt:StudyProduct_82fd7c74-ea4a-3e37-ba9a-116be9109767 imgt:Product_4dfdcc11-43d7-3ba0-8c58-bfd2cd24ea95|imgt:commun_name|REGN-1033 imgt:scFv-h-CH2-CH3_1189|obo:RO_0002162|imgt:Homsap imgt:PROTEIN_2ANDHALFREPEATS-PEG_275|obo:RO_0002162|imgt:Homsap imgt:Clone_549|obo:RO_0002162|imgt:Musmus imgt:C-ALPHA|rdfs:label|C-ALPHA imgt:Lymphoma_B_cell|imgt:isClinicalIndicationOf|imgt:StudyProduct_e3b31fb7-d1c1-364c-a5a4-bf9da72bae9d imgt:Segment_958_1|obo:BFO_0000050|imgt:Construct_958 imgt:StudyProduct_95f2348f-0d7e-3304-99e9-a1649fc0abe7|imgt:hasClinicalIndication|imgt:Facioscapulohumeral_muscular_dystrophy_(FSHMD) imgt:StudyProduct_55146c27-621e-353f-a87d-430a39e8e3e8|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_aafd0d68-6869-32fd-9b11-aa5205ba5962|imgt:hasClinicalIndication|imgt:Cancers_bladder imgt:mAb_420|rdf:type|obo:NCIT_C78838 imgt:TNFSF13B|imgt:isTargetOf|imgt:IgG1-lambda_266 imgt:Product_e5ca6245-7a11-3390-b7de-6b5e8870b2ab|imgt:hasStudyProduct|imgt:StudyProduct_9df56d89-7734-31a2-afe0-c36ea005cff2 imgt:StudyProduct_bc693e63-c908-3a8a-9039-6678a1526aa9|imgt:isStudyProductOf|imgt:Product_b5ab73f0-6a7d-349a-8fac-132c9549ca1d imgt:StudyProduct_4e03a35f-639e-3c28-925a-2505a32230fa|imgt:hasExpressionSystem|imgt:_CHOK1SV_(expresses_glutamine_synthetase_(GS)_endogenously)_cells imgt:Product_87376b34-c995-367f-9c8c-6b74e4f5097b|imgt:hasStudyProduct|imgt:StudyProduct_0c373d90-768b-334b-9f1f-d5225dd3f2e3 imgt:IgG1-kappa_98|http://semanticscience.org/resource/SIO_000291|imgt:ERBB2 imgt:IgG2b-kappa_1008|rdf:type|imgt:MAbReceptor imgt:Amgen|imgt:produces|imgt:Product_db54ace8-9d0d-3afe-8d6e-8dda791a352c imgt:Construct_780|imgt:isConstructOf|imgt:IgG4-lambda2_780 imgt:StudyProduct_8b2e4e04-64d3-32a1-9c3e-b0f965cb7b77|imgt:hasClinicalPhase|imgt:Phase_II obo:NCIT_C174885|rdfs:subClassOf|obo:NCIT_C1909 imgt:CTAG1B|imgt:isTargetOf|imgt:BETA-ALPHA1_985 imgt:PROTEIN_5_1163|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/PROTEIN_5.png obo:NCIT_C91382|rdf:type|owl:Class imgt:Zhejiang_Hisun_Pharmaceutical_Co_LTD|rdfs:comment|Tai Zhou , China imgt:Segment_379_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:mAb_910|imgt:clinical_trials|6 studies found, 3 recruiting imgt:StudyProduct_531ed619-12fb-3aa0-b519-7fdb71523fd0|imgt:hasClinicalPhase|imgt:Phase_I obo:NCIT_C63546|rdfs:subClassOf|obo:NCIT_C1909 imgt:IgG1-kappa_296|rdf:type|imgt:MAbReceptor imgt:Product_7a3ec779-a1bd-30e8-a7a2-4a6524b06459|rdf:type|obo:NCIT_C51980 imgt:Construct_259|rdfs:label|Construct_259 imgt:mAb_771|imgt:hasImgtStructureEntry|imgt:10687 imgt:mAb_971|imgt:inn_number|11137 imgt:Clone_65|rdfs:label|Clone_65 imgt:Jasper_Therapeutics_Inc|rdfs:label|Jasper Therapeutics, Inc. imgt:Product_77016dda-c72a-3c2b-a774-67ee29fc1930|rdfs:label|Product_77016dda-c72a-3c2b-a774-67ee29fc1930 _:Bca13937a998780d0222ae768225f837f|rdf:type|obo:NCIT_C53285 imgt:Construct_759|rdfs:label|Construct_759 imgt:Construct_529|imgt:hasImgtLabel|imgt:IgG4-kappa _:Bf448a78aa715fa24872cd3df47cce52d|rdf:type|obo:NCIT_C53285 imgt:Cancers_colorectal_(CRC)_metastatic|imgt:isClinicalIndicationOf|imgt:StudyProduct_73eadf4f-ba04-320b-ad70-ae2133e4211b imgt:IgG1-kappa_891|rdf:type|imgt:MAbReceptor imgt:Construct_1105|rdfs:label|Construct_1105 imgt:Intracranial_hemorrhage_(ICH)|rdf:type|obo:NCIT_C185637 imgt:Product_55aa2dba-a058-31a7-91b8-376994712cb7|rdfs:label|Product_55aa2dba-a058-31a7-91b8-376994712cb7 imgt:StudyProduct_877034ef-cdfa-3d6f-a36c-87e6faef79ca|imgt:hasClinicalPhase|imgt:Phase_I pubmed:7688398|dc:contributor|Lewis A.P. imgt:IgG2-kappa_785|imgt:isMabReceptorOf|imgt:mAb_785 imgt:Construct_779|rdfs:label|Construct_779 imgt:Segment_1275_1|imgt:has_rank|1 imgt:Systemic_lupus_erythematosus_(SLE)|imgt:isClinicalIndicationOf|imgt:StudyProduct_91c8c4c2-c45b-3abc-b0d3-014bbfc1b9ab imgt:Product_4dc025d9-1a02-3974-9131-37a906a286fa|imgt:hasStudyProduct|imgt:StudyProduct_08184582-b131-3764-92a2-abfde04a4586 imgt:Clone_717|rdf:type|obo:NCIT_C37925 imgt:Segment_663_1|imgt:has_rank|1 imgt:mAb_718|imgt:hasProduct|imgt:Product_676ba184-966c-385e-a940-72fcf5428927 imgt:Product_4384026e-ba8b-350f-b05f-d196a99c173c|imgt:isProducedBy|imgt:Innovent_Biologics imgt:unproductive|rdfs:label|unproductive imgt:Product_b9226bfe-9ade-3567-89de-3debdadbfd1e|rdfs:label|Product_b9226bfe-9ade-3567-89de-3debdadbfd1e imgt:Clone_120|imgt:isOriginCloneOf|imgt:mAb_120 imgt:_CHO_DG44_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_ea0488b6-c294-342d-a0a3-e55774de78f0 imgt:RGMA|rdf:type|obo:NCIT_C25702 imgt:StudyProduct_5b4c30e9-b6a0-3e4a-9b78-588936d32aba|imgt:hasClinicalIndication|imgt:Solid_tumors imgt:IL2|rdf:type|imgt:ChainLabels imgt:IgG1-kappa_87|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png _:B67954950ff9e638ed93b5e4302c60e80|imgt:isDecisionOf|imgt:StudyProduct_b54609dc-bd12-356e-a5bf-77c43ed0825f imgt:Segment_495_1|rdfs:label|Segment_495_1 imgt:Product_432aca3a-1e34-3e33-9f35-a30c8f65edce|imgt:hasStudyProduct|imgt:StudyProduct_432aca3a-1e34-3e33-9f35-a30c8f65edce imgt:IgG4-kappa_886|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG4-kappa.png imgt:StudyProduct_6b5d1278-0160-3b0b-a1ec-85726c3ea55f|imgt:hasDecision|_:Be198b6bdb1cac3dd357b918f6c26ed30 imgt:Segment_88_1|imgt:has_rank|1 imgt:StudyProduct_49333971-7a17-388d-b9fe-f46c374ededb|imgt:hasClinicalPhase|imgt:Phase_M imgt:IgG1-kappa-4cys-drug_814|rdf:type|imgt:MAbReceptor imgt:StudyProduct_d8bb306f-3e8b-3b02-a6fd-7a1446b05de5|imgt:hasClinicalIndication|imgt:Non-Hodgkin's_lymphoma_(NHL)_follicular_CD20_positive_relapsed_or_refractory_low_grade imgt:L-IOTA|rdfs:label|L-IOTA imgt:StudyProduct_bc047f4c-b7b7-35d8-b830-4aee2324f3bd|imgt:hasClinicalPhase|imgt:Phase_I/II imgt:Product_ba224a9b-4a5f-36b6-9467-5dd2fff90eb2|imgt:commun_name|PF-04518600 imgt:FUSION-%5BCSF3%5D2-FC-GAMMA-4|rdf:type|imgt:CPCALabel imgt:Severe_acute_respiratory_syndrome_coronavirus_2_(SARS-CoV-2)_infection_(COVID-19)|imgt:isClinicalIndicationOf|imgt:StudyProduct_4b5bfd63-8cd3-3214-b48a-f4c898c46e26 imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_e5f9bc32-80ee-33ea-9c6d-c28d60583c72 imgt:Product_cb1dc7ce-b8b2-385d-93aa-ad7f2c2311af|rdfs:label|Product_cb1dc7ce-b8b2-385d-93aa-ad7f2c2311af imgt:StudyProduct_a16bd2cd-d0f6-3778-9c75-be3acebe62f5|imgt:hasClinicalPhase|imgt:Phase_III imgt:SCFV-LAMBDA-HEAVY-H-CH2-CH3|skos:definition|scFv comprising a V-LAMBDA, a VH and a H-CH1-CH2 domains pubmed:11373411|dc:contributor|Leighton A imgt:Construct_396|obo:BFO_0000051|imgt:Segment_396_1 imgt:IgG1-kappa-4cys_1059|rdfs:label|IgG1-kappa-4cys_1059 imgt:mAb_124|imgt:imgt_note| mAb radiolabelled used in radio-immuno-scintigraphy imgt:Product_2d751c55-5d4a-3190-8c83-f07f3ce81971|imgt:commun_name|RO5137382 imgt:mAb_1295|rdf:type|obo:NCIT_C1909 imgt:mAb_824|imgt:hasProduct|imgt:Product_261d61fb-02a3-3c36-8a44-8027b7a60a03 imgt:Construct_279|imgt:hasImgtLabel|imgt:IgG4-nd imgt:Product_38dcb3a9-d366-365a-80b8-285719fdf525|imgt:commun_name|inebilizumab-cdon imgt:IgG2-kappa_1147|imgt:isMabReceptorOf|imgt:mAb_1147 imgt:StudyProduct_c3c0cf49-3542-3af5-97f2-1bd2997da165|imgt:hasClinicalPhase|imgt:Phase_I imgt:IgG2-kappa_597|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG2-kappa.png imgt:Construct_118|obo:BFO_0000051|imgt:Segment_118_1 imgt:B-Tail|skos:definition| imgt:Product_5c04be23-e79a-3cda-a452-c8c13a5d1811|imgt:isProductOf|imgt:mAb_815 imgt:Product_64d31d25-899a-3941-a5d0-bc3b3c0b468b|imgt:commun_name|RG-6149 imgt:Product_96fc911e-455e-31e8-853b-3466ad4672d0|imgt:commun_name|FPA144 imgt:mAb_1041|imgt:hasMabReceptor|imgt:BETA-ALPHA1_1041 imgt:hasDomainType|rdfs:range|imgt:DomainType imgt:StudyProduct_2b299490-c54a-39a2-b2a2-8f33b6b1603b|imgt:isStudyProductOf|imgt:Product_0c4ce40c-4004-3873-ac20-3d6e604874e8 imgt:StudyProduct_388f6325-78d8-37ae-a6e6-3773ba3d75f0|imgt:application_type|Therapeutic imgt:mAb_637|imgt:hasMabReceptor|imgt:PROTEIN_1DOMAIN-PEG_637 imgt:10468|rdf:type|obo:NCIT_C25402 _:B100426e697a4d79619ab9f48a9452836|dc:date|2014-04-15 imgt:11797|imgt:isImgtStructureEntryOf|imgt:mAb_1112 imgt:Segment_19_1|rdfs:label|Segment_19_1 imgt:Product_f1256184-14be-352c-97bb-4a84a7bea8e0|imgt:commun_name|Huzaf imgt:mAb_393|imgt:centerwatch_link|http://www.centerwatch.com/drug-information/fda-approvals/drug-details.aspx?DrugID=997 imgt:Construct_1026|imgt:isConstructOf|imgt:IgG1-kappa_1026 imgt:Construct_1060|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Construct_483|rdf:type|imgt:Construct imgt:Product_3a2d4ce6-ee10-3606-bdbf-0fca75b2d07d|imgt:hasStudyProduct|imgt:StudyProduct_9937caad-f7d1-3094-978d-bf1219411187 imgt:_NS0_mouse_myeloma_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_2ceaa53e-6ad0-350e-8c2b-77078eee2f94 imgt:VH-VH%27-VH__trivalent_971|http://semanticscience.org/resource/SIO_000291|imgt:ALB imgt:StudyProduct_88a3fab2-d85c-3138-8bbc-f38ba854282c|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_7c032185-923e-30f0-809b-77357355d8de|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_9cf7da6f-4b72-3b2f-a8ca-1a7449fbbe45|imgt:hasClinicalIndication|imgt:Chronic_Obstructive_Pulmonary_Disease_(COPD) imgt:StudyProduct_b8d27e6b-3e65-397a-be65-a52394b34b40|rdf:type|obo:NCIT_C174271 _:B9704bcdf71a840956bd30d4e30f0fd56|imgt:hasDesignation|imgt:Orphan_drug imgt:mAb_1240|imgt:hasMabReceptor|imgt:IgG1-kappa_1240 imgt:StudyProduct_2de56e47-95ab-31a2-a6a2-9d15f1234094|rdfs:label|StudyProduct_2de56e47-95ab-31a2-a6a2-9d15f1234094 imgt:National_Cancer_Institute|imgt:produces|imgt:Product_a0661df8-0511-3add-a6da-197740d48a46 imgt:NRP1|rdfs:label|NRP1 imgt:mAb_11|imgt:hasBibliographicReference|https://doi.org/10.1038/332323a0 imgt:Segment_83_1|rdf:type|imgt:Segment imgt:Product_4975e7ab-7850-3795-8d34-6526bce56205|rdfs:label|Product_4975e7ab-7850-3795-8d34-6526bce56205 imgt:10993|rdf:type|obo:NCIT_C25402 imgt:Non-cutaneous_T_cell_lymphoma_(NCTCL)|rdf:type|obo:NCIT_C185637 imgt:StudyProduct_388f6325-78d8-37ae-a6e6-3773ba3d75f0|rdf:type|obo:NCIT_C174271 imgt:Product_537eec38-79cb-325f-9881-34398d511aa7|rdf:type|obo:NCIT_C51980 imgt:L-nt-SEQUENCE|rdf:type|imgt:PrototypeLabel imgt:Product_1aa37c1d-0409-3829-ba45-a5a52bab10aa|imgt:isProductOf|imgt:mAb_735 imgt:mAb_1092|imgt:imgt_note| dimer Musmus G2BK tetrakisdisulfide, conjugated on an average of 1 to 2 lysyl, to recombinant aglycosylated ricin toxin A (RTA) on cysteinyl 260 (via the heterobifunctional (amine- and sulfhydryl- reactive) 4-succinimidyloxycarbonyl-α-methyl-α-(2-pyridyldithio) toluene (SMPT) crosslinker). Major conjugation sites: H VH K82: 74, 74'' L C-KAPPA K35: 141’, 141''' ; K119: 206’, 206''' imgt:mAb_1208|imgt:hasImgtStructureEntry|imgt:11877 imgt:Construct_321|imgt:isConstructOf|imgt:IgG1-kappa_321 pubmed:15316127|dc:contributor|Wu AM imgt:mAb_751|imgt:hasProduct|imgt:Product_bd9c71b8-3d23-3a00-9baa-343c2be1d6e7 imgt:StudyProduct_67c736d0-c1aa-310e-a158-ecb43a8c9d1c|imgt:isStudyProductOf|imgt:Product_1d32d5b1-99c8-31ab-9a21-acfa4c132ab7 imgt:11647|rdfs:label|11647 _:B0125e788dd8a580ea5a131d557c2b4d0|imgt:isDecisionOf|imgt:StudyProduct_49333971-7a17-388d-b9fe-f46c374ededb imgt:CARRIER_BIG-PROTEIN_1DOMAIN_691|rdfs:label|CARRIER_BIG-PROTEIN_1DOMAIN_691 imgt:Clone_70|obo:RO_0002162|imgt:Musmus imgt:Segment_134_1|obo:BFO_0000050|imgt:Construct_134 imgt:ENZ_1DOMAIN_782|imgt:isMabReceptorOf|imgt:mAb_782 imgt:mAb_637|rdfs:label|mAb_637 imgt:mAb_716|imgt:hasImgtStructureEntry|imgt:10441 imgt:mAb_700|imgt:hasMabReceptor|imgt:ENZ-XTEN_700 _:Bb1650d90e3379663c73b15c8fd192eff|imgt:hasDesignation|imgt:Orphan_drug imgt:StudyProduct_0e54bccd-7463-3c62-b3aa-f7ef86c2fb45|imgt:isStudyProductOf|imgt:Product_483963c5-2edc-3412-9648-699e6b83a759 imgt:Product_6900c4b8-952b-3ae4-8daf-ac079d21e5eb|imgt:isProductOf|imgt:mAb_941 imgt:StudyProduct_d4bec2ab-9bf5-347c-8c6d-bc4f4c236179|rdfs:label|StudyProduct_d4bec2ab-9bf5-347c-8c6d-bc4f4c236179 imgt:Product_4bf3114f-4cbf-347a-af9a-2e7f19e6991f|rdfs:label|Product_4bf3114f-4cbf-347a-af9a-2e7f19e6991f imgt:Product_1e2fc063-05b8-30f0-827b-f5ed40b8c74a|imgt:commun_name|RO5083945 imgt:mAb_170|rdf:type|obo:NCIT_C166879 imgt:StudyProduct_051be517-b06a-3a73-a5b1-9fc71abaed12|imgt:application_type|Therapeutic imgt:StudyProduct_2ceaa53e-6ad0-350e-8c2b-77078eee2f94|rdfs:label|StudyProduct_2ceaa53e-6ad0-350e-8c2b-77078eee2f94 imgt:Product_9186186a-7147-3fe7-bbf9-599dbe1368ab|imgt:isProducedBy|imgt:Genentech_Inc imgt:Segment_980_1|rdf:type|imgt:Segment imgt:Construct_841|imgt:isConstructOf|imgt:IgG1-kappa_841 imgt:Segment_801_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:10806|imgt:isImgtStructureEntryOf|imgt:mAb_544 imgt:StudyProduct_64df6f56-9ee1-3540-ae4c-8f714b5cdb93|imgt:application_type|Therapeutic imgt:StudyProduct_e15b2151-8965-350c-87ec-1241381bb101|imgt:application_type|Therapeutic imgt:LILRA4|imgt:isTargetOf|imgt:IgG1-lambda_1068 imgt:StudyProduct_6f8cddae-e152-3d3a-b567-2a79a7822890|imgt:isStudyProductOf|imgt:Product_68afb854-61e9-3368-bcb1-806b4a0975fc imgt:9236|rdf:type|obo:NCIT_C25402 imgt:%5BACVR2B_(activin_A_receptor_type_2B_ActR-IIB_ActRIIB)%5D2-IGHG1_Fc_(Fragment_constant)|imgt:construction_detail|Fusion - [ACVR2B (activin A receptor type 2B, ActR-IIB, ActRIIB)]2 - IGHG1 Fc (Fragment constant) imgt:Segment_1053_1|obo:BFO_0000050|imgt:Construct_1053 imgt:Product_be72163f-78a5-3a36-89d3-87e234fb9f7b|imgt:hasStudyProduct|imgt:StudyProduct_30398458-77d5-32d6-8062-3cfe66167d41 imgt:Product_406390c3-6cd8-3629-be68-66016fce19cf|imgt:hasStudyProduct|imgt:StudyProduct_2b7fdb21-1c4b-3a3a-9d6c-870f0663ad27 imgt:StudyProduct_a3f0ef7c-24c2-3746-901e-38acdd728455|imgt:isStudyProductOf|imgt:Product_1d35d4a7-3f31-3f7c-bb34-858d027ec0c4 imgt:StudyProduct_30e7b18e-ba8f-3e71-90a6-671525dbbf3b|rdfs:label|StudyProduct_30e7b18e-ba8f-3e71-90a6-671525dbbf3b obo:NCIT_C116788|rdfs:subClassOf|obo:NCIT_C1909 imgt:mAb_577|imgt:inn_number|10186 imgt:StudyProduct_1ba64066-4a99-3e7e-b455-83858d45f09f|rdfs:label|StudyProduct_1ba64066-4a99-3e7e-b455-83858d45f09f imgt:half-G1-kappa_scFv-HEAVY-LAMBDA-h-CH2-CH3_921|rdf:type|imgt:MAbReceptor imgt:mAb_220|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=220 imgt:Construct_171|rdf:type|imgt:Construct imgt:1FGV|imgt:isImgtStructureEntryOf|imgt:mAb_46 imgt:Product_c299e202-690b-3ffc-8c53-e45056548ad0|imgt:hasStudyProduct|imgt:StudyProduct_84943707-93aa-3f08-8787-9270eb6f179d imgt:exemptia™|rdfs:comment| EXEMPTIA™ developed by Zydus Cadila (Ahmedabad India) biosimilar of HUMIRA® approved by India (DCGI) on December 9 2014. _:B5766a3193fa23c55b69f31bdf9de7a52|rdf:type|obo:NCIT_C53285 imgt:CD4|imgt:isTargetOf|imgt:MAbReceptor_69 pubmed:16796401|rdf:type|bibo:Article imgt:StudyProduct_e2e0e4e8-186e-366d-bf96-3cdbf085e738|imgt:hasClinicalPhase|imgt:Phase_II imgt:GH1_(growth_hormone_1_somatotropin_GH_GH-N_GHN_hGH-N_pituitary_growth_hormone)|rdfs:label|GH1 (growth hormone 1, somatotropin, GH, GH-N, GHN, hGH-N, pituitary growth hormone) imgt:mAb_1295|rdf:type|imgt:INN imgt:StudyProduct_893f347b-7704-315d-8d0c-ccda42a5e13a|imgt:development_technology| Abgenix's XenoMouse® obo:NCIT_C175143|rdfs:subClassOf|obo:NCIT_C1909 imgt:StudyProduct_d09bb3d6-e5ad-3a18-a0be-17b78e4b532d|imgt:hasDecision|_:Be61918caddd0402dc9821dac66d2472e imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_7a8a4321-2c20-3c9b-b98e-ac1a3008529e imgt:mAb_1003|rdf:type|obo:NCIT_C139549 imgt:Product_2136ea09-1f27-3c33-93cc-520404243949|rdfs:label|Product_2136ea09-1f27-3c33-93cc-520404243949 imgt:StudyProduct_e66b4ba4-8439-37c2-b264-1a3a6aeac91f|imgt:application_type|Therapeutic imgt:Segment_691_2|rdf:type|imgt:Segment imgt:_Sp2/0_mouse_hybridoma_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_ae60550c-07fd-3957-8211-175259773781 imgt:Segment_1050_1|rdf:type|imgt:Segment imgt:1V-1C-1C-LIKE_1V-1C-1C-LIKE|rdfs:label|1V-1C-1C-LIKE_1V-1C-1C-LIKE imgt:Zhejiang_Hisun_Pharmaceutical_Co_LTD|imgt:produces|imgt:Product_11969236-9244-388c-8c27-50a230df66d2 imgt:Segment_174_1|rdf:type|imgt:Segment imgt:Product_f2202260-1eb1-3ea7-b7bb-a7ab1d7930ea|imgt:hasStudyProduct|imgt:StudyProduct_56707d84-4db0-39aa-b4f3-46813eb2b013 imgt:mAb_747|imgt:hasProduct|imgt:Product_c5ff1e2f-3b88-3253-8ff2-5532b29230b5 imgt:9269|imgt:isImgtStructureEntryOf|imgt:mAb_395 imgt:Product_7e372f5e-216d-3aa4-ad79-792648eecc36|rdfs:label|Product_7e372f5e-216d-3aa4-ad79-792648eecc36 imgt:mAb_335|imgt:inn_proposed_list|102 (2009) imgt:Segment_694_2|rdf:type|imgt:Segment imgt:StudyProduct_88292b86-7a14-37c5-9681-001550cab8be|rdf:type|obo:NCIT_C174271 imgt:IgG1-kappa_1093|obo:RO_0002162|imgt:Chi imgt:IgG1-kappa_817|http://semanticscience.org/resource/SIO_000291|imgt:TNFRSF17 imgt:Product_b9a7e713-902d-3fb3-afff-5da968f3c336|imgt:hasStudyProduct|imgt:StudyProduct_cf928976-b0b8-39a0-92fc-e8fa9339991f imgt:SCFV-LAMBDA-HEAVY|skos:definition|scFv comprising a V-LAMBDA and a VH domains imgt:IgG2-kappa_196|imgt:hasConstruct|imgt:Construct_196 imgt:IG-Light-Sigma-IGS|rdfs:label|IG-Light-Sigma-IGS imgt:StudyProduct_b87ee559-aea6-37ce-82b5-a1c9e1c007a2|imgt:hasClinicalPhase|imgt:Phase_II _:B363cbe14f3fe3f4eac7d9e31c2df130f|imgt:hasStatut|imgt:approval imgt:9235|imgt:isImgtStructureEntryOf|imgt:mAb_171 imgt:StudyProduct_45b6062e-6ed8-34fb-baf5-fa526b0c3293|imgt:application_type|Therapeutic imgt:Non-radiographic_axial_spondyloarthritis_(nraxSpA)|imgt:isClinicalIndicationOf|imgt:StudyProduct_7bad9e61-b26d-376c-b785-9c694f61a571 _:Bf4540e227114506d138be1c7e968a5d6|dc:date|2011-11-18 imgt:Clone_1185|rdf:type|obo:NCIT_C37925 imgt:Construct_410|rdfs:label|Construct_410 imgt:Product_9b8fd23d-77df-3897-9633-83ec58c245d0|imgt:hasStudyProduct|imgt:StudyProduct_e3ffb74c-0ceb-3d93-adaa-56c66b4f3b79 imgt:FN1-2|skos:definition|Fibronectin I imgt:StudyProduct_dbf9c186-16b6-3efe-bf6e-d1dc4dd0f50c|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:Product_eee3061f-bf14-3e3d-9646-c7c2fe6d3166|imgt:hasStudyProduct|imgt:StudyProduct_51ff04a9-18a5-33e6-b557-c38f878f45b7 imgt:11116|rdfs:label|11116 imgt:mAb_892|imgt:hasMabReceptor|imgt:IgG1-kappa_892 imgt:mAb_3|rdfs:label|mAb_3 imgt:Atopic_dermatitis_(AD)|imgt:isClinicalIndicationOf|imgt:StudyProduct_9359aae2-9b31-354e-971c-ba17df48da1a _:Bd7450b27b98029f1c52d7843466e877e|imgt:isDecidedBy|imgt:FDA 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imgt:IG-Heavy-Mu-IGHM|imgt:defines|imgt:IgM_Iota-3 imgt:Segment_1105_1|rdf:type|imgt:Segment imgt:Product_7c5b4231-8351-3ed9-ba1d-8c48699ed506|imgt:hasStudyProduct|imgt:StudyProduct_3fce70b5-9444-3ae3-9ec4-143ceeeeb147 imgt:IgA2_Kappa|rdf:type|imgt:ReceptorType imgt:Segment_1135_1|rdf:type|imgt:Segment imgt:Product_70b50ee7-2b02-3707-9e71-2aa4dc650f26|rdfs:label|Product_70b50ee7-2b02-3707-9e71-2aa4dc650f26 imgt:Construct_612|imgt:isConstructOf|imgt:CPCA_PROTEIN-PEG-FC_612 imgt:StudyProduct_3abdc460-ed74-31b3-b553-27cf2bfb2c0b|rdfs:label|StudyProduct_3abdc460-ed74-31b3-b553-27cf2bfb2c0b imgt:mAb_852|imgt:hasProduct|imgt:Product_5dea998c-cfea-32c4-a7bd-01fd1839b7c7 imgt:pro-MSTN|skos:definition|pro-MSTN (pro-growth differentiation factor 8, pro-GDF8, pro-myostatin, pro-GDF-8) imgt:Segment_85_1|rdf:type|imgt:Segment imgt:StudyProduct_c41a5aad-60fe-3bea-a5d7-9fe2d148dc75|rdf:type|obo:NCIT_C174271 imgt:mAb_312|imgt:inn_recommended_list|33 (1993) imgt:SEMA4D|skos:definition|SEMA4D (sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D) imgt:10856|rdf:type|obo:NCIT_C25402 imgt:VH-C-kappa-CH2-CH3_V-lambda-CH1_H-GAMMA-1_L-kappa_500|imgt:hasConstruct|imgt:Construct_500 imgt:mAb_221|imgt:hasOriginClone|imgt:Clone_221 imgt:Clone_151|obo:RO_0002162|imgt:Musmus imgt:Rheumatoid_arthritis_(RA)|imgt:isClinicalIndicationOf|imgt:StudyProduct_185b82b9-df56-3ad2-94f8-31f51bdf8e85 imgt:StudyProduct_1e2bc35b-44f3-3a3b-8938-77751325cdeb|imgt:isStudyProductOf|imgt:Product_b14b8aa8-e5fd-36c2-a182-be2c0d32c945 _:B04eef8029062734e9f1fd07cd94db222|imgt:isDecisionOf|imgt:StudyProduct_39a07acf-358e-3f3a-825b-9ea75267ff72 imgt:StudyProduct_ef744953-59b3-316f-a39b-32b3310940ca|imgt:isStudyProductOf|imgt:Product_d1ff3524-abf9-3a7a-93d3-8b514c80da83 imgt:IgG1-kappa_1035|imgt:hasMolecularComponent|imgt:IG pubmed:1836485|dc:contributor|Kurrle R. imgt:mAb_291|imgt:inn_recommended_list|62 (2009) imgt:mAb_151|imgt:hasImgtStructureEntry|imgt:4KRP imgt:Cancers|imgt:isClinicalIndicationOf|imgt:StudyProduct_5788b43b-a000-348c-803e-6c7dbb249d7e imgt:mAb_849|rdfs:label|mAb_849 imgt:Product_b0d0c09a-7196-3fc5-8676-4db70c57ba7c|imgt:hasStudyProduct|imgt:StudyProduct_cb415f04-8f17-3d90-b008-249903036395 imgt:IgG1-kappa_410|rdf:type|imgt:MAbReceptor imgt:Construct_787|rdf:type|imgt:Construct imgt:CPCA_PROTEIN-FC_820|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/CPCA_PROTEIN-FC.png imgt:IgG1-kappa_760|rdfs:comment|IgG1 - kappa imgt:StudyProduct_d08001fe-9bd8-377d-b56d-2cffd39b2bdd|imgt:hasClinicalPhase|imgt:Phase_I imgt:mAb_1130|imgt:inn_name|latozinemab imgt:bivalent|rdf:type|obo:NCIT_C25702 imgt:mAb_662|imgt:clinical_trials|4 studies found, 2 recruiting imgt:Product_dc5d0295-91f0-3aeb-9b3e-15ed4c4c9f19|rdf:type|obo:NCIT_C51980 imgt:has_number|rdfs:label|has_number imgt:Clone_176|imgt:isOriginCloneOf|imgt:mAb_176 imgt:mAb_301|imgt:hasImgtStructureEntry|imgt:9128 imgt:10646|imgt:isImgtStructureEntryOf|imgt:mAb_766 imgt:FUSION-%5BACVRL1%5D2-FC-GAMMA-1|rdfs:label|FUSION-[ACVRL1]2-FC-GAMMA-1 imgt:StudyProduct_a3efdb33-e7a0-3712-96a4-1d95f7771e48|imgt:hasClinicalPhase|imgt:Phase_III imgt:Product_be140b70-fccf-3adc-ab0e-066855350e81|imgt:isProductOf|imgt:mAb_846 imgt:Product_161f8d36-1cee-338d-88ce-55a0108d54a3|imgt:isProductOf|imgt:mAb_1027 imgt:11532|imgt:isImgtStructureEntryOf|imgt:mAb_1156 imgt:Construct_1205|imgt:isConstructOf|imgt:IgG1-kappa_1205 imgt:mAb_863|imgt:inn_name|toripalimab imgt:Product_1ecfbd73-bd44-3962-8d08-3af82d492b28|imgt:isProductOf|imgt:mAb_649 imgt:Product_b9e8379b-d30f-37fb-ac2e-44ad77f3f669|imgt:isProductOf|imgt:mAb_874 imgt:IgG1-nd_440|imgt:hasConstruct|imgt:Construct_440 imgt:IgG1-kappa_321|imgt:hasMolecularComponent|imgt:IG imgt:StudyProduct_f765eebb-5180-3806-84f0-27613a9fb127|rdfs:label|StudyProduct_f765eebb-5180-3806-84f0-27613a9fb127 imgt:Segment_1178_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Segment_929_1|rdfs:label|Segment_929_1 imgt:StudyProduct_c8dad9b0-2c1e-3c06-8d49-121c7f612e1f|imgt:hasClinicalIndication|imgt:Graft-versus-host_disease_(GvHD) imgt:Product_11743f52-8d52-3e88-b8df-04e83be3502a|imgt:isProductOf|imgt:mAb_828 imgt:Segment_213_2|imgt:hasImgtLabel|imgt:IGHG1 imgt:Idiopathic_inflammatory_myopathy_(IIM)|rdf:type|obo:NCIT_C185637 _:B77f9a7ec89a2a15885263d48c327001a|imgt:isDecisionOf|imgt:StudyProduct_bf8c29b4-cfc3-3b87-833f-e4568c7831db imgt:Segment_828_1|imgt:has_rank|1 imgt:IgG1-kappa_716|rdfs:comment|IgG1 - kappa _:B5ad7a6ec832e46209737e95c2f2391c4|dc:date|2002-12-31 imgt:Product_dd5b0ea7-dfc0-3434-88fe-69d7271939ab|imgt:hasStudyProduct|imgt:StudyProduct_344e061b-7133-38c4-8a1f-ec5e4af282a2 imgt:mAb_456|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=456 imgt:mAb_1089|rdfs:label|mAb_1089 imgt:Product_4d3d979f-bb24-30ea-893d-e9685175b749|rdfs:label|Product_4d3d979f-bb24-30ea-893d-e9685175b749 imgt:Product_589c62e2-46ec-3016-ac0f-8ee0131ebfaf|imgt:commun_name|SA-237 imgt:Segment_214_3|imgt:hasImgtLabel|imgt:IGHG1 imgt:StudyProduct_d1e3b696-3c02-3d2b-88e8-b57f5a72c6df|imgt:hasExpressionSystem|imgt:_E.coli_(Escherichia_coli) imgt:protein|dc:identifier|imgt_000073 imgt:Product_1b47dcca-8b27-33c3-b6b2-d9c5cd3d4a8b|imgt:commun_name|BAY 1112623 imgt:StudyProduct_dc38fe22-e028-31bc-9ca5-e6847212466f|imgt:hasDecision|_:Bb5d87ce371271b8c02e253226f545365 imgt:Product_d3f3fc46-b4d3-3454-a1c7-97eae9e1a634|rdfs:label|Product_d3f3fc46-b4d3-3454-a1c7-97eae9e1a634 imgt:mAb_670|imgt:imgt_note| INN amendment (74)(36) for the Spanish description. imgt:Product_16b9cd69-afab-35b0-baa4-0f9528d73b6b|imgt:comercial_name|LEMTRADA® imgt:Product_2367188d-88a7-3ccc-a7b8-b36893ebf8c4|imgt:isProducedBy|imgt:PDL_(Protein_Design_Labs)_BioPharma imgt:Clone_65|imgt:isOriginCloneOf|imgt:mAb_65 imgt:mAb_279|imgt:hasProduct|imgt:Product_ce822f79-054d-3661-8bf4-37f73f52daa5 imgt:1F-DOMAIN-1C-LIKE|rdfs:label|1F-DOMAIN-1C-LIKE obo:NCIT_C179104|rdf:type|owl:Class imgt:mAb_432|imgt:hasMabReceptor|imgt:IgG1-kappa-4cys-drug_432 imgt:Product_ed5e913a-f7f4-32d3-aab5-2a234ed41808|imgt:isProductOf|imgt:mAb_1117 imgt:Construct_1078|imgt:isConstructOf|imgt:IgG1-kappa_1078 imgt:StudyProduct_11ac2320-3ae3-3557-ae97-a40a10f1798b|imgt:isStudyProductOf|imgt:Product_c311e57b-5fdf-3259-ae3a-0eab5583a035 imgt:StudyProduct_d2145572-8fa1-3560-8662-8fefc008eb2f|imgt:hasClinicalIndication|imgt:Asthma_severe imgt:Product_a0dd8b7d-497f-3e1b-9202-688a37f0520c|imgt:commun_name|SYNT-001 imgt:StudyProduct_f3f90a44-ad85-3097-8693-98c7a6e9f52f|imgt:application_type|Therapeutic imgt:Clone_1265|obo:RO_0002162|imgt:Musmus imgt:Non-Hodgkin's_lymphoma_(NHL)|imgt:isClinicalIndicationOf|imgt:StudyProduct_309cbdae-97a1-314b-83a0-f3f22f4b4747 imgt:mAb_393|imgt:atc_link|http://www.whocc.no/atc_ddd_index/?code=B02BX04 imgt:Clone_110|imgt:isOriginCloneOf|imgt:mAb_110 imgt:StudyProduct_eb9705c1-9ee0-374d-b6e8-001505ff7206|rdf:type|obo:NCIT_C174271 imgt:mAb_590|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=590 imgt:mAb_945|rdfs:label|mAb_945 imgt:mAb_1300|imgt:inn_number|11931 imgt:Product_e16c7e73-bafd-3c00-8679-3d3179baac20|imgt:commun_name|GX-I7 imgt:Product_e75484d6-63ef-3d47-8150-d13346757f21|rdf:type|obo:NCIT_C51980 imgt:Segment_552_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:mAb_1214|imgt:inn_name|upanovimab imgt:11030|imgt:isImgtStructureEntryOf|imgt:mAb_937 imgt:IgG1-kappa_911|imgt:isMabReceptorOf|imgt:mAb_911 imgt:Construct_417|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Segment_647_1|rdfs:label|Segment_647_1 imgt:mAb_387|rdfs:label|mAb_387 imgt:IgG2-kappa_646|http://semanticscience.org/resource/SIO_000291|imgt:CALCA imgt:Segment_65_1|imgt:hasImgtLabel|imgt:Fab-G1-kappa imgt:StudyProduct_398f308f-7331-387c-99c3-f1e0ab230bc5|rdfs:label|StudyProduct_398f308f-7331-387c-99c3-f1e0ab230bc5 imgt:J-CHAIN|imgt:describes|imgt:J-chain imgt:StudyProduct_7f3598b4-32e2-3b41-bebe-259b4020fe75|imgt:hasExpressionSystem|imgt:_CHO_DG44_(Chinese_Hamster_Ovary)_cells imgt:mAb_220|imgt:imgt_note| As of August 2009, Medarex, Inc. operates as a subsidisary of Brystol-Myers Squibb company. MDX-H210 (F(ab') anti-ERBB2 murine 520C9 x F(ab’) anti-CD64 humanized H22) was obtained by chemical cross-linking with o-phenylenedimaleimide of 520C9 F(ab') and H22 F(ab'). H22 F(ab') binds CD64 (FcγRI) (but outside the normal ligand binding site for IgG) and 520C9 F(ab') binds ERBB2. MDX-H210 directs CD64-positive effector cells (monocytes, macrophages, immature dendritic cells, G-CSF primed neutrophilis (polymorphonuclear cells (PMN)) to tumor cells that overexpress ERBB2, to phagocyte or kill them. Bispecific identifies an antibody with two different variable domain binding sites (Fv), each binding to a different antigen. imgt:Mapp_Biopharmaceutical_Inc|rdfs:comment|San Diego , USA imgt:Clone_55|imgt:clone_name|D1.3 imgt:Roche_F_Hoffmann-La_Roche_Ltd|imgt:produces|imgt:Product_31d88f86-f890-3c06-9160-b268bfdcdad5 imgt:StudyProduct_422b563f-43e3-308c-8b21-895b0539ecd5|imgt:development_technology| POTELLIGENT® technology (afucosylation) imgt:IgG4-kappa_587|imgt:hasConstruct|imgt:Construct_587 imgt:Construct_963|obo:BFO_0000051|imgt:Segment_963_1 imgt:LIGM|imgt:produces|imgt:Product_83dc02ca-3c73-3e6f-bbf3-aa5349d0883d imgt:IgG1-kappa_168|rdf:type|imgt:MAbReceptor imgt:Neuromyelitis_optica_(NMO)|imgt:isClinicalIndicationOf|imgt:StudyProduct_332ed26b-007f-3cdb-b618-a362512d9730 imgt:StudyProduct_bdfc03ae-258c-35c5-944d-ccc2478989da|rdfs:label|StudyProduct_bdfc03ae-258c-35c5-944d-ccc2478989da imgt:Product_a906e8c2-5cd0-31d0-9f46-849a19d4b85b|imgt:hasStudyProduct|imgt:StudyProduct_8a7cffa2-ee9b-30b9-a732-f2a8a18eaccd imgt:iCo_Therapeutics_Inc|rdf:type|obo:NCIT_C54131 imgt:StudyProduct_a0f66fd1-f754-3772-b98b-83a1b533b65d|rdf:type|obo:NCIT_C174271 imgt:Product_fe170d32-2e79-37f8-b44b-a495e80a927a|imgt:hasStudyProduct|imgt:StudyProduct_38804e2c-8020-32ad-8f9e-7e0a6981e8ab imgt:Segment_478_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:StudyProduct_3e16d3fd-70c4-39f2-b5ac-6f1f8100a26c|imgt:isStudyProductOf|imgt:Product_8f4bc0b9-33eb-3dac-aba0-4e658471c39a imgt:mAb_782|imgt:hasProduct|imgt:Product_0ca89df9-4af8-318a-82c3-74e6893c18d2 imgt:StudyProduct_3fd941bf-0663-37c6-81e0-47e586d03fba|imgt:hasExpressionSystem|imgt:_Sp2/0_mouse_hybridoma_cells imgt:Segment_785_1|rdfs:label|Segment_785_1 imgt:Product_8aab193e-5ea6-3d52-8519-ee1de15448f9|imgt:isProducedBy|imgt:Acticor_Biotech imgt:decavalent|imgt:isTargetOf|imgt:IgM-kappa_scFv-heavy-kappa_1257 imgt:Clone_344|imgt:clone_name|mBR96 (Musmus IgG3-kappa) imgt:F(ab)2-nd-nd|rdfs:label|F(ab')2 - nd - nd imgt:StudyProduct_14ef875e-bf47-3078-9f6e-3462f0e48969|imgt:hasClinicalIndication|imgt:Lymphoma_follicular_(FL) imgt:Diagnosis_of_ostomyelitis|imgt:clinical_domain|Osteology imgt:StudyProduct_f8ea0962-96ab-3f9b-80d2-b5d260255e59|imgt:hasClinicalIndication|imgt:Allograft_rejection imgt:Product_e3009342-baa5-36fb-ad94-0743b8782e11|imgt:commun_name|SCH900222 imgt:Product_74d376fb-ff8e-340f-a10b-23eefb61dbad|rdfs:label|Product_74d376fb-ff8e-340f-a10b-23eefb61dbad imgt:mAb_1074|imgt:hasMabReceptor|imgt:scFv-scFv-scFc_kappa-lambda_1074 imgt:Multiple_myeloma_(MM)|imgt:isClinicalIndicationOf|imgt:StudyProduct_aae454ab-ebb6-3ed9-9d8e-cbe255693209 imgt:StudyProduct_2523ae41-58c5-34a2-a352-75ae04be2b97|rdfs:label|StudyProduct_2523ae41-58c5-34a2-a352-75ae04be2b97 imgt:Construct_546|rdf:type|imgt:Construct imgt:FC-DELTA|rdf:type|imgt:IGProteolyticFragmentLabel imgt:Progressive_supranuclear_palsy_(PSP)|rdf:type|obo:NCIT_C185637 imgt:Construct_1090|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Segment_614_1|rdf:type|imgt:Segment imgt:Construct_449|rdf:type|imgt:Construct imgt:StudyProduct_b0c9b53b-2f37-3115-9c67-115435d102b8|imgt:hasExpressionSystem|imgt:_COS_cells_transient_expression imgt:StudyProduct_1e3d13d6-30e9-30d3-90c2-86212912f6e9|imgt:hasClinicalIndication|imgt:Respiratory_Syncytial_Virus_(RSV)_infection imgt:PROTEIN_1DOMAIN-PEG_629|rdfs:label|PROTEIN_1DOMAIN-PEG_629 imgt:Xenova_Biomedix_Limited|imgt:produces|imgt:Product_d9212299-036c-39af-b29c-31d7fe01268c imgt:Product_8bdb3425-f72a-3777-be41-82fdaed26099|imgt:isProductOf|imgt:mAb_101 obo:NCIT_C88327|rdfs:subClassOf|obo:NCIT_C1909 imgt:Segment_546_1|imgt:hasImgtLabel|imgt:scFv imgt:mAb_1093|imgt:inn_recommended_list|85 (2021) imgt:Colitis_ulcerative_(UC)|imgt:isClinicalIndicationOf|imgt:StudyProduct_54c8df76-003b-3fb6-ae0b-a64c19682dd5 imgt:IgG4-kappa_606|imgt:isMabReceptorOf|imgt:mAb_606 imgt:StudyProduct_5ba733d3-a9b0-3fca-b17c-8f2433a04435|imgt:isStudyProductOf|imgt:Product_69e0603e-e62c-3164-b2bd-120ef0150778 imgt:Product_7206ce92-2c30-3a53-96b4-d2f0bd2f1dd3|imgt:commun_name|IBI-939 imgt:mAb_130|imgt:inn_recommended_list|44 (2000) imgt:Segment_716_1|obo:BFO_0000050|imgt:Construct_716 obo:NCIT_C111906|rdf:type|owl:Class imgt:StudyProduct_8a6d066c-b385-3587-a404-674ccff69832|imgt:hasClinicalIndication|imgt:Frontotemporal_Dementia imgt:Construct_404|rdfs:label|Construct_404 imgt:Clone_1037|imgt:isOriginCloneOf|imgt:mAb_1037 imgt:ERBB3|skos:definition|ERBB3 (receptor tyrosine-protein kinase erbB-3, HER3) _:B30129f331b9e8f99c6fbfe00339205e1|dc:date|2010-01-25 imgt:Segment_1020_1|imgt:has_rank|1 imgt:Construct_166|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:IgG2a-kappa_125|imgt:isMabReceptorOf|imgt:mAb_125 imgt:MAbReceptor_74|imgt:isMabReceptorOf|imgt:mAb_74 imgt:mAb_535|imgt:inn_number|10051 imgt:J-C-transcript|rdf:type|imgt:Molecule_EntityType imgt:_CHO-K1|imgt:isExpressionSystemOf|imgt:StudyProduct_aaf066df-3656-3025-80a3-0e31ed88ed73 imgt:StudyProduct_d8975ef7-2490-31f4-bc09-19a2451ae706|imgt:hasClinicalPhase|imgt:Phase_II/III imgt:IgG1-nd_19|imgt:hasConstruct|imgt:Construct_19 imgt:IgG1-kappa_200|rdfs:comment|IgG1 - kappa imgt:StudyProduct_4ae01645-c1e9-38af-86e6-d49652281689|imgt:hasClinicalIndication|imgt:Inflammatory_bowel_disease_(IBD) imgt:mAb_999|imgt:inn_proposed_list|122 (2019) imgt:centerwatch_link|rdfs:label|centerwatch_link pubmed:15664918|dc:contributor|D Alia G imgt:Millennium_Pharmaceuticals_Inc|imgt:produces|imgt:Product_a0ad7eed-cb27-395a-a42a-66344074cbf9 _:B17f9e03feebcc3a15f1123b88cd51821|imgt:isDecisionOf|imgt:StudyProduct_58f6469b-e86d-3dd8-9b5d-98dd2e3173f2 imgt:Product_1c7d468c-7793-33f3-a5bd-6747d51e1199|imgt:isProducedBy|imgt:BioAtla_LLC imgt:Segment_215_2|imgt:segment_detail|Fc (Fragment constant) imgt:Segment_106_1|imgt:has_rank|1 imgt:Psoriasis|imgt:isClinicalIndicationOf|imgt:StudyProduct_dec3e93b-f8fd-3f69-8b0f-c893f2bf1763 _:B82d3eb42cf786219cf31f7520182677e|imgt:hasStatut|imgt:approval imgt:SLITRK6|rdfs:label|SLITRK6 imgt:StudyProduct_ca42b321-4efb-3ab3-95da-0abbfe6974d2|imgt:hasClinicalIndication|imgt:Cardiomyopathy_associated_with_dystrophinopathies imgt:VPREB1_IGLL1|rdf:type|imgt:RPILabel imgt:StudyProduct_5178c5cc-f29f-305c-9bc4-7f34d28046d4|imgt:hasClinicalPhase|imgt:Phase_I _:Ba951270162c2c9730309dce91ee6bba9|imgt:isDecidedBy|imgt:FDA imgt:Prototype|skos:definition|An IMGT prototype is the graphical representation of an entity with IMGT® standardized labels (capital letters, no plural) [1, 2]. IMGT prototypes are defined for molecular entities in IMGT® databases and tools. imgt:Product_747d2bfa-44b6-3feb-95ae-81e3134044b6|imgt:isProductOf|imgt:mAb_1196 imgt:Construct_1266|obo:BFO_0000051|imgt:Segment_1266_1 imgt:Product_4cc47359-f3f3-3da9-9e42-fd7f4c895ef3|imgt:isProducedBy|imgt:Alexion_Pharmaceuticals_Inc imgt:mAb_916|imgt:inn_proposed_list|120 (2018) imgt:mAb_1234|imgt:hasMabReceptor|imgt:scFv-heavy-kappa-IgG1-h-CH2-CH3(CO)-CD28(TM-CY1)-CD247(CY2)_1234 imgt:Product_c8390c36-6b3e-3a6e-bce0-3d7d542ca6fe|rdf:type|obo:NCIT_C51980 imgt:mAb_642|imgt:inn_recommended_list|77 (2017) imgt:Product_9724eb93-89cb-3cab-ad25-ea60d12dbfca|imgt:commun_name|ABBV-399 imgt:mAb_962|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=962 imgt:10528|rdf:type|obo:NCIT_C25402 imgt:MAbReceptor_511|imgt:isMabReceptorOf|imgt:mAb_511 _:Be7334b9835ecb2faf2a099d90a1a005a|imgt:isDecidedBy|imgt:FDA imgt:StudyProduct_9c3a5a8b-bb37-30bf-8a8c-f8134d5ffcf7|imgt:isStudyProductOf|imgt:Product_feba6bcf-b6af-3f3b-bb5a-1ac0b3da5702 imgt:VH-CD3E|rdf:type|imgt:ChainLabels imgt:Primary_cutaneous_anaplastic_large_cell_lymphoma_(pcALCL)|imgt:clinical_domain|Hematology imgt:Feline_atopic_dermatitis_(AD)|imgt:isClinicalIndicationOf|imgt:StudyProduct_f96588b4-d3c1-35cb-b6d7-f2867a3f3bbe imgt:Segment_766_1|rdf:type|imgt:Segment imgt:StudyProduct_ec3380df-8e7d-3c53-a53d-6d97d49448d0|imgt:isStudyProductOf|imgt:Product_cfe7feb8-af89-32b0-b422-e41ff6ece0e5 obo:NCIT_C170236|rdf:type|owl:Class imgt:Product_3628c1e7-8007-3900-aa02-fcb45866cf72|imgt:hasStudyProduct|imgt:StudyProduct_8fe16f6f-1d15-3ebd-a29a-5600ea1fef34 imgt:IgG1-kappa_857|rdf:type|imgt:MAbReceptor imgt:Construct_613|obo:BFO_0000051|imgt:Segment_613_2 imgt:Gilead|imgt:produces|imgt:Product_6bc98c9a-0b0b-3b1e-a407-ec0e4a4c2c92 imgt:Elan_Pharmaceuticals_International_Ltd|rdfs:comment|Dublin , Ireland imgt:Segment_753_1|rdf:type|imgt:Segment imgt:IG-Gene|rdfs:label|IG-Gene imgt:G1-kappa_scFv-h-CH2-CH3_1083|obo:RO_0002162|imgt:Hum imgt:mAb_763|imgt:inn_number|10638 imgt:Product_7223271e-99bc-3aad-b1dc-917ee78af247|imgt:commun_name|GA101 imgt:StudyProduct_e7879970-9f95-3f40-9bfc-e60c454fd71c|rdfs:label|StudyProduct_e7879970-9f95-3f40-9bfc-e60c454fd71c imgt:StudyProduct_7b861a94-9e6b-3cac-af47-59cbb1fad6a4|imgt:application_type|Therapeutic imgt:StudyProduct_0073239e-4b51-34b4-b68a-9247058363c5|imgt:hasClinicalIndication|imgt:Cancers_non-small_cell_lung_(NSCLC) imgt:IgG1-kappa_966|imgt:isMabReceptorOf|imgt:mAb_966 imgt:StudyProduct_4fdcd687-2c1c-3c05-9943-0108644d68a2|imgt:hasClinicalPhase|imgt:Phase_II imgt:Product_43b270ab-cd45-3fb5-8ca6-df0952c4ef21|imgt:commun_name|VIB-4920 imgt:AbbVie_Inc|imgt:produces|imgt:Product_9724eb93-89cb-3cab-ad25-ea60d12dbfca imgt:StudyProduct_5a1d70be-9799-3766-a0cf-3fcdf0fffb95|imgt:hasClinicalIndication|imgt:Cancers_non-small_cell_lung_(NSCLC) imgt:10938|imgt:isImgtStructureEntryOf|imgt:mAb_963 imgt:Center_of_Molecular_Immunology_(CMI)|rdfs:label|Center of Molecular Immunology (CMI) imgt:Product_161f8d36-1cee-338d-88ce-55a0108d54a3|rdfs:label|Product_161f8d36-1cee-338d-88ce-55a0108d54a3 imgt:mAb_1061|imgt:hasProduct|imgt:Product_691a766e-3d58-36e0-8d0f-f9070665bc53 imgt:_Sp2/0_mouse_hybridoma_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_14f772b0-9f8c-32bb-9418-26d0843c3f20 imgt:mAb_1300|rdf:type|obo:NCIT_C1909 imgt:mAb_314|rdf:type|imgt:INN imgt:IgG1-kappa_1143|imgt:hasMolecularComponent|imgt:IG imgt:mAb_783|imgt:hasMabReceptor|imgt:IgG1-kappa_783 imgt:StudyProduct_db1471ac-0b14-38e9-ae83-f5e6efc97f5f|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:Construct_477|obo:BFO_0000051|imgt:Segment_477_1 imgt:Construct_826|obo:BFO_0000051|imgt:Segment_826_3 imgt:Segment_802_1|imgt:has_rank|1 imgt:mAb_366|imgt:hasBibliographicReference|pubmed:21154168 _:B1bf75098e709ec0814604a314a240213|rdf:type|obo:NCIT_C53285 imgt:Clone_660|rdfs:label|Clone_660 imgt:Product_cd47e1b0-c5b3-3b90-8d93-b3ae11351271|imgt:commun_name|YFC51.1 imgt:IgG1-kappa_1007|imgt:hasConstruct|imgt:Construct_1007 imgt:Inflammatory_conditions|rdf:type|obo:NCIT_C185637 imgt:Migraine|rdf:type|obo:NCIT_C185637 imgt:Clone_380|imgt:isOriginCloneOf|imgt:mAb_380 imgt:Clone_1253|rdfs:label|Clone_1253 imgt:StudyProduct_58d35ed7-b3d3-3a25-b756-b10a69992df4|imgt:hasClinicalPhase|imgt:Phase_I/II imgt:mAb_112|imgt:inn_proposed_list|84 (2000) imgt:IgG1-kappa_362|imgt:hasMolecularComponent|imgt:IG imgt:hasGeneType|rdfs:label|hasGeneType imgt:Construct_764|obo:BFO_0000051|imgt:Segment_764_1 obo:NCIT_C82422|rdfs:subClassOf|obo:NCIT_C1909 imgt:Clone_320|rdf:type|obo:NCIT_C37925 imgt:mAb_607|imgt:inn_number|10265 imgt:StudyProduct_3ff2cb83-f81b-3da6-9128-579440ac058a|imgt:hasDecision|_:Bd7c02b105e7f1b4ef4d04dee640a7f61 imgt:PDCD1|imgt:isTargetOf|imgt:IgG4-kappa_659 imgt:IgG1-kappa_761|rdfs:comment|IgG1 - kappa imgt:FCGRT|imgt:isTargetOf|imgt:IgG1-lambda_1020 imgt:StudyProduct_69f05125-2eb8-3c5c-94c7-42377fb1de9a|imgt:hasDecision|_:B88a4cd04c02582bd4faeee4b95bdedae imgt:Product_770ad40f-89bb-3a05-96a9-fffbdef50c28|rdf:type|obo:NCIT_C51980 imgt:Segment_702_1|obo:BFO_0000050|imgt:Construct_702 imgt:Cancer_gynecology|imgt:clinical_domain|Oncology imgt:Product_d34f1ebd-acfa-3151-b703-7247bec7bb83|imgt:hasStudyProduct|imgt:StudyProduct_474aa71c-98e8-33be-a008-be448cf8004d imgt:IgG1-kappa-S239C_2cys-drug_904|imgt:isMabReceptorOf|imgt:mAb_904 imgt:Product_f246242d-cc24-305b-8e9f-06e04804a59b|imgt:commun_name|TNFR-immunoadhesin imgt:Product_af6553e7-92df-3b88-98d1-af503f23f416|imgt:hasStudyProduct|imgt:StudyProduct_c1f882ca-c7ae-33f6-a4cf-a85ff91d4c50 imgt:Product_9cefcc4e-84ab-3c12-a0f3-3b8d369271d8|imgt:isProductOf|imgt:mAb_1080 imgt:cDNA|skos:definition|Identifies complementary DNA, a nucleotide sequence made of A, T, C, G, obtained in vitro by reverse transcription of mRNA. imgt:AA-chain|dc:identifier|imgt_000009 pubmed:8152440|dc:contributor|Sato K imgt:StudyProduct_feae6a22-c82c-3d95-9134-7ab7f653eba9|imgt:hasClinicalPhase|imgt:Phase_M imgt:StudyProduct_bf390145-1da6-3243-8c8b-6e1b025d646b|imgt:hasClinicalPhase|imgt:Phase_III imgt:FPIA_%5BPROT-PROT%5D2-FC_615|imgt:hasConstruct|imgt:Construct_615 imgt:PROTEIN_2DOMAINS_933|imgt:isMabReceptorOf|imgt:mAb_933 imgt:Segment_763_1|imgt:has_rank|1 imgt:PROTEIN_1DOMAIN_1235|imgt:hasMolecularComponent|imgt:RPI imgt:StudyProduct_9a6054ff-7c0c-3a40-b2cb-7c00af55551b|imgt:hasClinicalIndication|imgt:Asthma imgt:Segment_330_1|obo:BFO_0000050|imgt:Construct_330 imgt:BETA-ALPHA1_1160|rdfs:label|BETA-ALPHA1_1160 imgt:Molecule_StructureType|owl:disjointWith|imgt:TaxonomyRelated_StructureType imgt:Segment_615_2|imgt:has_rank|2 imgt:DOMAIN|skos:definition| imgt:StudyProduct_e56ab5b1-3248-3291-b805-2ba2f0c9b846|imgt:hasClinicalPhase|imgt:Phase_II imgt:Clone_1266|imgt:isOriginCloneOf|imgt:mAb_1266 imgt:FormatType|rdfs:label|FormatType imgt:AstraZeneca|rdfs:comment|London , UK imgt:CD3E|imgt:isTargetOf|imgt:IgG1-kappa_92 imgt:StudyProduct_fdbfed3e-6d3c-31a1-ab0c-e84a3891fa36|imgt:hasClinicalIndication|imgt:Osteoarthritis_(OA) imgt:Product_de6b73a9-944b-34bc-ad4c-f6cbd43ea96a|rdf:type|obo:NCIT_C51980 _:B4931e70eb4a49cda47c6f0b705e0a802|imgt:isDecisionOf|imgt:StudyProduct_6e1d6f70-6543-3bce-a73d-eacbc56df1a3 imgt:Anemia_autoimmune_hemolytic_(AIHA)|imgt:clinical_domain|Hematology imgt:Product_bcdbc732-0e68-3d51-a3f0-9d67628fb792|imgt:comercial_name|ZENAPAX® (EC withdrawal 2009) imgt:StudyProduct_4bb50129-b3f6-36d9-b2a1-041dcec42164|imgt:isStudyProductOf|imgt:Product_4f8eaec9-4859-3ace-a16d-f9d4aac8c48e imgt:Product_ae14f792-c7fc-3b1a-8720-eab3244c9808|imgt:hasStudyProduct|imgt:StudyProduct_06f7f86b-9caf-3c74-88da-482672c16dbf imgt:mAb_508|rdfs:label|mAb_508 imgt:mAb_1292|rdfs:label|mAb_1292 imgt:scFv-kappa-heavy-CD8A_(CO-TM)-N6_(CY)-CD247_1102|rdfs:comment|scFv-kappa-heavy-CD8A (CO-TM)-N6 (CY)-CD247 imgt:Clone_320|obo:RO_0002162|imgt:Musmus _:B236d46e37332be9aa08087895a995cdf|dc:date|2017-06-15 imgt:ziextenzo™|rdfs:comment| ZIEXTENZO™ (pegfilgrastim-bmez LA-EP2006) developed by Sandoz Inc. (Wilson NC USA) approved by FDA on November 4 2019 (BLA) 761045 Same clinical indications as NEULASTA®. imgt:Allergic_asthma|rdf:type|obo:NCIT_C185637 obo:NCIT_C174931|rdf:type|owl:Class imgt:Product_07aac662-fdf7-3468-a89e-5ca369b8c228|imgt:isProducedBy|imgt:Roche_F_Hoffmann-La_Roche_Ltd _:B44563f1afb4b72bd04bf10fbbc75de90|imgt:isDecisionOf|imgt:StudyProduct_33f0c871-917c-343e-a485-18b51d0b2bb4 imgt:StudyProduct_270e18d4-f055-3ae0-b682-a1ad76b279d9|imgt:isStudyProductOf|imgt:Product_90c8d5c4-a75e-3484-8230-3404f25c120c imgt:FPIA_%5BPROTEIN_3REPEATS%5D2-FC_935|rdfs:label|FPIA_[PROTEIN_3REPEATS]2-FC_935 imgt:Product_c5ff1e2f-3b88-3253-8ff2-5532b29230b5|imgt:commun_name|Maxy-VII imgt:Lymphoma_follicular_(FL)|imgt:isClinicalIndicationOf|imgt:StudyProduct_d0b75517-b3bd-32f4-a4dc-f5bfdbf17b0e imgt:ERBB2|imgt:isTargetOf|imgt:IgG1-kappa-4cys-drug_668 imgt:Product_d8f8f32a-4a56-3077-910a-bd55a9d0cae3|rdfs:label|Product_d8f8f32a-4a56-3077-910a-bd55a9d0cae3 imgt:Product_383a1300-0d4b-3eb4-8be6-9861ce4aa999|rdf:type|obo:NCIT_C51980 imgt:Product_9152abee-e3e8-3240-868b-21aaee47b104|imgt:hasStudyProduct|imgt:StudyProduct_94c7e46a-7966-38fb-913d-79740edf49b7 imgt:Construct_1213|obo:BFO_0000051|imgt:Segment_1213_1 obo:NCIT_C153084|rdfs:subClassOf|obo:NCIT_C1909 imgt:Segment_1030_1|imgt:has_rank|1 imgt:_CHO-K1|imgt:isExpressionSystemOf|imgt:StudyProduct_a186afa2-4718-3a82-81f9-640ec7c1cc30 imgt:Product_eee3061f-bf14-3e3d-9646-c7c2fe6d3166|imgt:isProductOf|imgt:mAb_220 imgt:StudyProduct_e9448e9b-2d6c-31a8-a5fa-b02d1a05de2a|imgt:application_type|Therapeutic imgt:Eisai_Co_Ltd|imgt:produces|imgt:Product_b902d379-45ba-3460-955c-938cf82600f1 imgt:mAb_332|rdf:type|obo:NCIT_C84520 imgt:Construct_828|rdf:type|imgt:Construct imgt:mAb_366|imgt:imgt_note| Utilizing the POTELLIGENT® technology MHLW : Japanese Ministry of Health, Labor and Welfare FUT8 knockout CHO cell line (FUT8-/-). FUT8 encodes an α-1,6-fucosyltransferase that catalyzes the transfer of fucose from GDP-fucose to N-acetylglucosamine (GlcNAc) in an α-1,6 linkage.\r The CHO cell line is derived from Potelligent® Ms704 CHO cells (Biowa) \r Both FUT8 genes were disrupted in a Chinese hamster ovary (CHO)/DG44 cell line by sequential homologous recombination (Yamane-Ohnuki N. et al. biotechnol. Bioeng., 87(5) :614-622, 2004. PMID: 15352059 imgt:Segment_1203_1|obo:BFO_0000050|imgt:Construct_1203 imgt:Appolomics_Inc|imgt:produces|imgt:Product_5c704ad4-2680-304a-a836-b24fbaa6e9d1 imgt:StudyProduct_6ee58395-ba07-36f4-abe7-f7b57669944c|imgt:hasDecision|_:B7d1af592f5a7f5a0d362048086b2e614 imgt:Taimed_Biologics_Inc|rdfs:comment|Ivine , USA imgt:Product_5361ee36-3770-3139-a6be-27e3520b6392|imgt:hasStudyProduct|imgt:StudyProduct_9108fff6-407c-323f-a8aa-62f846a87212 imgt:StudyProduct_3b191dcf-99b4-3707-b950-63b947220000|rdf:type|obo:NCIT_C174271 imgt:mAb_564|imgt:inn_recommended_list|75 (2016) imgt:StudyProduct_8d3868ac-3c34-3283-8620-988f40279e1e|imgt:hasClinicalIndication|imgt:Solid_tumors imgt:mAb_805|rdf:type|imgt:INN imgt:StudyProduct_aaf34cfb-ccb6-39bf-a6ae-0c91c314772d|rdf:type|obo:NCIT_C174271 _:Bcdce87d7c43754275c848eccc307a1cc|dc:date|2015-10-09 imgt:10186|rdf:type|obo:NCIT_C25402 imgt:StudyProduct_a5efddc8-bf21-3fc9-987f-11778f5c8a4b|imgt:development_technology| Cambridge Antibody Technology (CAT) human antibody phage display library imgt:Product_8e8a1379-1ce0-3a6f-bd30-ded74b8a8b53|imgt:hasStudyProduct|imgt:StudyProduct_dc38fe22-e028-31bc-9ca5-e6847212466f imgt:Construct_788|rdf:type|imgt:Construct imgt:SIRPA|rdf:type|imgt:SegmentLabels imgt:StudyProduct_23514241-6079-3d3b-b77f-feedb96c88e7|imgt:hasClinicalIndication|imgt:Acute_coronary_syndrome_(ACS) imgt:Construct_834|rdfs:label|Construct_834 imgt:Construct_1108|rdf:type|imgt:Construct imgt:mAb_249|imgt:clinical_trials|223 studies found, 61 recruiting _:B7ce2850c3ac4b450e404dd4747c6bd8c|imgt:isDecisionOf|imgt:StudyProduct_7ed7242f-3444-378f-812e-8ff84c1f6368 imgt:StudyProduct_2502c008-4153-3c07-87e6-dd6eb2a47480|imgt:development_technology| Human antibody phage display library imgt:OncoMed_Pharmaceuticals|imgt:produces|imgt:Product_8cbc64f1-a09e-3b24-8971-ec6382ae015a imgt:StudyProduct_1e3d13d6-30e9-30d3-90c2-86212912f6e9|imgt:development_technology| VelocImmune® VelociGene® imgt:IgG1-Fab-kappa-lambda_1286|http://semanticscience.org/resource/SIO_000291|imgt:bispecific imgt:Product_7e664528-a961-3eda-8e83-9135554c8676|imgt:isProducedBy|imgt:University_of_Bern imgt:mAb_976|imgt:inn_proposed_list|121 (2019) imgt:mAb_534|rdfs:label|mAb_534 imgt:StudyProduct_f9299f34-0498-3669-bc70-7aac6a583c76|imgt:hasClinicalPhase|imgt:Phase_M imgt:StudyProduct_7d100d5a-05e0-3ffb-ad07-68ea0a7560bd|imgt:hasClinicalIndication|imgt:Rheumatoid_arthritis_(RA) imgt:IgG1-kappa_1193|imgt:isMabReceptorOf|imgt:mAb_1193 imgt:Product_09c862c7-fb75-303d-94b6-542f658ababc|imgt:hasStudyProduct|imgt:StudyProduct_b4f563ea-ccf4-35fb-8a1e-7a37ea7c98f2 imgt:MAbReceptor_993|imgt:hasMolecularComponent|imgt:IG obo:NCIT_C175768|rdf:type|owl:Class imgt:mAb_477|rdf:type|obo:NCIT_C174693 imgt:mAb_246|imgt:imgt_note| Immunoadhesin: An immunoadhesin is a protein constituted of binding domain(s) (usually from a receptor, ligand, or cell-adhesion molecule) linked to immunoglobulin constant domains (Fc regions).br /An immunoadhesin is identified by the suffix b-cept/b in its INN. Discontinued August 29, 2011, in phase II, by Biogen Idec, as not differentiated from belimumab (BENLYSTA®), an anti-TNFSF13B mAb approved by the FDA on March 10, 2011. imgt:StudyProduct_73f5f5ca-2a3d-37b5-8182-03eec8cde324|rdfs:label|StudyProduct_73f5f5ca-2a3d-37b5-8182-03eec8cde324 imgt:Construct_140|imgt:isConstructOf|imgt:IgM-nd_140 imgt:scFv-heavy-kappa|rdf:type|imgt:ConstructLabels imgt:V-D-gene|skos:definition|Identifies, for gDNA, molecule entities with a rearranged V gene and a partially_rearranged D gene. V-D-gene is in partially_rearranged configuration. imgt:Product_32e24328-6c7b-375a-89c3-aca2f2e5265b|imgt:commun_name|RG-7624 imgt:Clone_560|imgt:isOriginCloneOf|imgt:mAb_560 imgt:Construct_1206|rdfs:label|Construct_1206 pubmed:20593411|imgt:isBibliographicReferenceOf|imgt:mAb_404 imgt:StudyProduct_94c0040f-b4c8-3e29-9d30-5d34c53c3c22|rdfs:label|StudyProduct_94c0040f-b4c8-3e29-9d30-5d34c53c3c22 imgt:Pieris_Pharmaceuticals_Inc|rdfs:label|Pieris Pharmaceuticals, Inc. imgt:Construct_917|imgt:hasImgtLabel|imgt:chorionic_gonadotropin imgt:StudyProduct_89a7f282-c155-362c-89f9-8467980d2e13|imgt:application_type|Therapeutic imgt:Construct_118|rdfs:label|Construct_118 imgt:StudyProduct_94d8dc7c-0c7e-33a1-a27f-260b76dbf359|rdf:type|obo:NCIT_C174271 imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_7289b3aa-ea74-386c-9a9e-4d0f250eaaaa imgt:IgM-nd_147|imgt:isMabReceptorOf|imgt:mAb_147 imgt:Severe_acute_respiratory_syndrome_coronavirus_2_(SARS-CoV-2)_infection_(COVID-19)|imgt:isClinicalIndicationOf|imgt:StudyProduct_3fe8e925-30b8-30ce-8efb-22088860ac21 imgt:StudyProduct_2374f0d0-d23a-3648-8be8-4f44a9fff16c|imgt:development_technology| Chimeric antigen receptor (CAR) T cell engineering imgt:Product_cfe151a6-7bb2-3ece-b611-96636f3e77a4|imgt:commun_name|RO-7187797 obo:NCIT_C152505|rdf:type|owl:Class imgt:mAb_825|imgt:hasProduct|imgt:Product_657435f7-f40d-38ac-90bc-de64a58754b9 imgt:mAb_801|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=801 imgt:Product_e3450730-2fa2-3a06-96d7-066f268ee1a7|imgt:hasStudyProduct|imgt:StudyProduct_ebae25c4-1751-3f03-935f-833a3a2334c3 imgt:Segment_779_1|rdf:type|imgt:Segment imgt:VH-VH-CD8A-TNFRSF9-CD247|rdf:type|imgt:ChainLabels imgt:Product_a0ad7eed-cb27-395a-a42a-66344074cbf9|imgt:comercial_name|ENTYVIO™ imgt:mAb_527|rdfs:label|mAb_527 imgt:Product_fc42260f-2c18-39ae-b730-f7c667362547|imgt:isProducedBy|imgt:Pfizer imgt:StudyProduct_72a23b84-4f21-3b8e-bf8a-f83e3940c4ec|imgt:application_type|Therapeutic imgt:IgG4-kappa_241|http://semanticscience.org/resource/SIO_000291|imgt:CD4 imgt:mAb_632|imgt:hasProduct|imgt:Product_75eafa99-1920-3a21-9a27-a04a05a3e0ec _:B64e681c19649b7dc1faf4a9fd2dcd0c6|dc:date|1992-09-14 imgt:CY-PART1|rdf:type|imgt:RegionLabel imgt:mAb_1241|imgt:inn_proposed_list|126 (2022) imgt:StudyProduct_1e1f523c-957a-3bbe-815b-42f4acdd376f|imgt:hasClinicalIndication|imgt:Crohn's_disease_(CD) imgt:Clone_1090|rdfs:label|Clone_1090 _:B37796d13dab923b311b8c64d417b5bc2|imgt:isDecidedBy|imgt:FDA imgt:mAb_843|rdf:type|obo:NCIT_C166821 imgt:StudyProduct_23514241-6079-3d3b-b77f-feedb96c88e7|imgt:development_technology| Nanobody® imgt:F3|imgt:isTargetOf|imgt:IgG1-kappa_577 imgt:StudyProduct_a3da2412-b16f-3690-aa14-7a2378b27b83|rdfs:label|StudyProduct_a3da2412-b16f-3690-aa14-7a2378b27b83 imgt:StudyProduct_0e404088-fe07-3e25-8630-993e3507585c|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_4a0a6e3a-0139-3c93-b656-67e46a290237|imgt:application_type|Therapeutic imgt:mAb_888|imgt:hasMabReceptor|imgt:IgG1-kappa_888 imgt:StudyProduct_f00d500d-e77e-390f-81f4-b51fbab69ce3|imgt:hasClinicalPhase|imgt:Phase_M imgt:StudyProduct_7086b4e6-1cf2-38da-99db-ef38a86426b7|imgt:hasExpressionSystem|imgt:_CHOK1SV_(expresses_glutamine_synthetase_(GS)_endogenously)_cells imgt:IgG1-kappa_407|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:mAb_895|imgt:inn_name|telitacicept imgt:Clone_185|rdfs:label|Clone_185 imgt:StudyProduct_1bc2e1b0-235f-3fd7-895d-a9145c6ef8b1|imgt:hasClinicalIndication|imgt:Cancers_non-small_cell_lung_(NSCLC) imgt:Construct_349|obo:BFO_0000051|imgt:Segment_349_1 imgt:Product_ba43734d-62ba-3121-bacd-1df363311834|rdf:type|obo:NCIT_C51980 imgt:Product_60a7e5e0-2e5d-36e9-bbf7-3aa985aa9408|imgt:isProductOf|imgt:mAb_588 imgt:Killer_cell_lectine-like_receptor|rdf:type|owl:Class imgt:10553|rdf:type|obo:NCIT_C25402 imgt:StudyProduct_377f3992-732b-368c-b12f-637fffb1f087|rdf:type|obo:NCIT_C174271 imgt:IgG4-kappa_1013|imgt:isMabReceptorOf|imgt:mAb_1013 imgt:mAb_1058|rdf:type|imgt:INN imgt:IG-Heavy-Gamma-1-IGHG1|rdfs:label|IG-Heavy-Gamma-1-IGHG1 obo:NCIT_C177059|rdf:type|owl:Class imgt:LRRNT|rdf:type|imgt:RepeatLabel imgt:IgM-kappa|imgt:construction_detail|IgM - kappa imgt:StudyProduct_a31ebf55-c0ae-3332-83f0-cfccbd94947d|imgt:application_type|Diagnostic imgt:ICAM1|imgt:isTargetOf|imgt:IgG1-lambda_800 obo:NCIT_C152664|rdfs:subClassOf|obo:NCIT_C1909 _:Bcc84cc2c449124b1183d754136d58601|dc:date|2010-06-22 _:B676317add7a9f2ac18ababcea89d8733|imgt:isDecisionOf|imgt:StudyProduct_c2bd6159-8e75-386c-9f57-f367043b6bb0 imgt:Segment_745_1|rdf:type|imgt:Segment imgt:StudyProduct_894e7dce-e66b-3f46-8f3e-980db30eee88|rdfs:label|StudyProduct_894e7dce-e66b-3f46-8f3e-980db30eee88 _:B2c97b6b35b492232e5d29e8b2823a4d2|rdf:type|obo:NCIT_C53285 imgt:Lupus_nephritis|imgt:isClinicalIndicationOf|imgt:StudyProduct_cad06487-fba8-32fe-ac47-aae7c63a6693 imgt:5HYQ|imgt:isImgtStructureEntryOf|imgt:mAb_151 imgt:mAb_479|imgt:inn_proposed_list|110 (2013) imgt:Optic_neuritis|rdfs:label|Optic_neuritis imgt:Product_a8aee7ed-d8a8-3435-a215-dfca28920b4d|rdf:type|obo:NCIT_C51980 imgt:Renal_Cell_Carcinoma_(RCC)_advanced|imgt:isClinicalIndicationOf|imgt:StudyProduct_d5e64d12-6fe7-3ada-9816-61c4a97ed8ed imgt:StudyProduct_6d3e53e4-920d-34ae-9702-c5eb443db708|imgt:application_type|Therapeutic imgt:Product_20f07591-c6fc-3220-bfe6-37cda29bb3f6|rdfs:label|Product_20f07591-c6fc-3220-bfe6-37cda29bb3f6 imgt:StudyProduct_d624aebd-571b-3a22-aa38-218d85e4a9a5|imgt:development_technology| Artificial human phage display library imgt:Clone_94|rdfs:label|Clone_94 imgt:StudyProduct_670de969-0702-323b-94f9-41ae8f7a1d2b|rdfs:label|StudyProduct_670de969-0702-323b-94f9-41ae8f7a1d2b imgt:StudyProduct_111c964b-269e-348c-b610-755fde6ed112|imgt:application_type|Therapeutic imgt:StudyProduct_e8f455cb-d010-3743-8608-f60a9b968429|imgt:hasClinicalIndication|imgt:Malignant_melanoma imgt:StudyProduct_a86a899c-9155-3966-b3b4-7a02a5a3f363|imgt:hasDecision|_:B24739eac063da2e8a03bb93004d231fa imgt:TR-Alpha-TRAC|imgt:hasChainTypeLevel|imgt:TR-Alpha-TRA imgt:IgG4-kappa_418|http://semanticscience.org/resource/SIO_000291|imgt:NGF imgt:Product_01aa0fdc-6298-3406-8d85-80c740496dd1|rdf:type|obo:NCIT_C51980 imgt:Construct_1040|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:StudyProduct_c286e60e-41e0-36d5-b2cb-d414b008e43d|imgt:development_technology| TRuC-T Cell Therapy imgt:Clone_1013|rdfs:label|Clone_1013 imgt:mAb_573|rdf:type|obo:NCIT_C152582 imgt:IgG1-lambda-4cys-drug_665|imgt:via_a| partially reduced S-cystine sulfurhydryl groups imgt:Product_1c7d468c-7793-33f3-a5bd-6747d51e1199|imgt:isProductOf|imgt:mAb_1269 obo:NCIT_C104167|rdf:type|owl:Class imgt:Solid_tumors|imgt:isClinicalIndicationOf|imgt:StudyProduct_a2cf14ef-242a-32b4-817c-814f3fcb2e78 imgt:mAb_724|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=724 imgt:Glaucoma_surgery|imgt:clinical_domain|Ophthalmology imgt:StudyProduct_34a1caac-6f2c-3e1e-9946-120ac114ef28|rdfs:label|StudyProduct_34a1caac-6f2c-3e1e-9946-120ac114ef28 imgt:Construct_639|rdf:type|imgt:Construct imgt:FPIA_%5BPROTEIN%5D2-FC_926|rdf:type|imgt:MAbReceptor imgt:StudyProduct_d08001fe-9bd8-377d-b56d-2cffd39b2bdd|rdfs:label|StudyProduct_d08001fe-9bd8-377d-b56d-2cffd39b2bdd imgt:%5BPEP%5D15|skos:definition|Chain or receptor VAC imgt:10898|rdfs:label|10898 pubmed:18088084|dc:contributor|Patel R imgt:StudyProduct_4be745c4-3084-3be0-bc46-8406ddd707b1|imgt:hasDecision|_:B9fbc0aee9b03c91f0d9e484b9f3b4363 imgt:StudyProduct_e0f5c364-3739-3455-886d-621fd42eaa3b|imgt:development_technology| Dual-Affinity Re-targenting (DART®) imgt:Segment_105_1|imgt:has_rank|1 _:Bfd334cdbbd98d6c2ef3df0a27e18f83c|dc:date|2014-08-14 imgt:Segment_828_1|imgt:hasImgtLabel|imgt:scFv-kappa-heavy imgt:StudyProduct_0bfe55ef-4480-30eb-b211-3dc2d511fa9e|imgt:hasDecision|_:B994e98b28d16c39ba2a9cd9e9bbb1f9e imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_e6f8d005-98be-31e4-9c9f-cee3e576b051 imgt:Construct_301|imgt:isConstructOf|imgt:IgG1-kappa_301 imgt:Construct_879|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:10994|rdf:type|obo:NCIT_C25402 _:B6910f37f2d84e0f3f59a84433aabd2ca|imgt:hasStatut|imgt:approval imgt:StudyProduct_f53e30ea-a3de-35af-974e-1cfe117d9fce|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:Construct_976|rdf:type|imgt:Construct imgt:Clone_935|imgt:isOriginCloneOf|imgt:mAb_935 imgt:ROR1|rdf:type|obo:NCIT_C25702 imgt:Segment_87_1|rdfs:label|Segment_87_1 imgt:mAb_867|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=867 _:B05f0df4244db1e8303df38a9ab9f1e13|imgt:isDecidedBy|imgt:FDA imgt:StudyProduct_755c9b10-ee5e-3939-ad41-4f1df088cebf|imgt:hasClinicalIndication|imgt:Cancers_head_and_neck imgt:IgG1-nd_840|imgt:conjugated_with| duostatin-5 imgt:IgG1-kappa_765|obo:RO_0002162|imgt:Homsap imgt:Product_fe2095b0-23dc-3a46-919e-533ea9681115|rdfs:label|Product_fe2095b0-23dc-3a46-919e-533ea9681115 imgt:mAb_293|imgt:hasImgtStructureEntry|imgt:9085 imgt:Syntimmune|rdfs:label|Syntimmune imgt:Product_79c48f1c-e47e-37e0-a142-44132cbf3ead|imgt:hasStudyProduct|imgt:StudyProduct_9a6054ff-7c0c-3a40-b2cb-7c00af55551b imgt:bispecific|imgt:isTargetOf|imgt:(scFv-kappa-heavy)-(scFv-heavy-kappa)_101 imgt:IgG1-kappa_165|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:IGHG4|rdf:type|imgt:SegmentLabels imgt:Product_94679014-1264-3d40-af82-d997b52a4481|imgt:commun_name|VRS-859 imgt:mAb_560|imgt:hasMabReceptor|imgt:IgG1-kappa_560 imgt:Product_bf5d4fd3-0df7-3e8b-b83a-7f0e170fc5f1|imgt:isProductOf|imgt:mAb_331 imgt:StudyProduct_22c6ada5-2eee-37e2-9148-181ded19c630|imgt:hasClinicalIndication|imgt:Melanoma_metastatic imgt:V-KAPPA|skos:definition|V-DOMAIN of a L-KAPPA chain imgt:mAb_223|imgt:hasImgtStructureEntry|imgt:8894 imgt:2HWZ|rdf:type|obo:NCIT_C25402 imgt:Product_e521e71e-0d27-3157-a807-f8780c379245|imgt:isProducedBy|imgt:Chugai_Pharmaceutical_Co_Ltd _:B28e143124171a2016dec4e580e494853|imgt:isDecidedBy|imgt:FDA imgt:mAb_871|imgt:clinical_trials|15 studies found, 9 recruiting imgt:Clone_1219|rdf:type|obo:NCIT_C37925 imgt:StudyProduct_bcf5f861-d839-306f-ad71-a30f20e56075|rdfs:label|StudyProduct_bcf5f861-d839-306f-ad71-a30f20e56075 pubmed:1279672|dc:contributor|Crowe J.EJr. imgt:Construct_555|obo:BFO_0000051|imgt:Segment_555_1 imgt:Product_5afec3ec-290b-336b-a08f-33a38d788b45|imgt:commun_name|S80880 imgt:StudyProduct_3e8a1cc1-7db6-3b17-a247-0d25e03076e5|imgt:isStudyProductOf|imgt:Product_8e8a1379-1ce0-3a6f-bd30-ded74b8a8b53 imgt:Segment_1164_1|rdfs:label|Segment_1164_1 imgt:StudyProduct_dcb34807-4868-33f7-b1ca-f367fbeefcbc|imgt:isStudyProductOf|imgt:Product_ccaee58d-d4c1-3c86-90f0-df9bb7bf2ae1 _:B9c1f1837c3effbe131e9b79fa2c3764a|dc:date|2020-08-25 imgt:StudyProduct_a19c7e6d-dacb-3962-ad32-ab8dfbf103b1|imgt:hasClinicalIndication|imgt:Cancers_colorectal_(CRC) imgt:mAb_486|imgt:clinical_trials|31 studies found, 6 recruiting _:B265fef9cd1c3abfd6b202a5b5245a966|imgt:hasStatut|imgt:approval imgt:mAb_1217|imgt:hasProduct|imgt:Product_f4dda718-cf10-3efb-a60a-ef580f59896d imgt:Product_8a1b8bbe-2945-3cb5-b953-e62a4fdd3269|rdf:type|obo:NCIT_C51980 imgt:Product_e1a45191-3ce1-3854-8d8e-bbc72e11be98|imgt:hasStudyProduct|imgt:StudyProduct_01549b7c-b89b-3100-ab84-41fa0b04e2a5 imgt:isTaxonomyRelatedStructureTypeOf|rdfs:domain|imgt:TaxonomyRelated_StructureType imgt:Product_e759fefd-9101-3729-bd7b-5f4394e694e6|imgt:commun_name|CS-1008 imgt:9810|rdfs:label|9810 imgt:Segment_226_1|imgt:has_rank|1 pubmed:7688398|dc:contributor|Rowan W. imgt:Product_944016ff-54ec-3384-b70a-18daff0aa3ff|imgt:isProducedBy|imgt:Seattle_genetics_Inc _:Bde72025626b3729c3542aafedce82d63|dc:date|2016-08-29 imgt:Construct_1014|imgt:isConstructOf|imgt:VH-VH%27_1014 imgt:PROTEIN_1DOMAIN-PEG_629|rdf:type|imgt:MAbReceptor imgt:IL2RB|imgt:isTargetOf|imgt:IgG1-kappa-%5BPROTEIN%5D2_1223 imgt:Construct_83|obo:BFO_0000051|imgt:Segment_83_1 imgt:Construct_60|rdf:type|imgt:Construct imgt:mAb_918|imgt:inn_number|11005 imgt:F(ab’)2-Alpha-2_Lambda|rdf:type|imgt:ReceptorType imgt:StudyProduct_017746a5-9da5-3dbd-bb4e-cba495f42531|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_8d1909f5-6c18-35cb-86f4-7cc986f94ba2|imgt:isStudyProductOf|imgt:Product_27b2ce59-fbe0-3c24-abf6-bf39a8d6c18b imgt:mAb_44|rdf:type|obo:NCIT_C171025 imgt:StudyProduct_efdf3dbb-e6b7-392b-a3c4-12cc4066e98e|rdfs:label|StudyProduct_efdf3dbb-e6b7-392b-a3c4-12cc4066e98e imgt:Juvenile_Idiopathic_Arthritis_(JIA)|imgt:clinical_domain|Immunology imgt:Fv-Heavy_Kappa|rdf:type|imgt:ReceptorType imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_a338e658-345d-3777-af9b-578f4b8496d0 imgt:StudyProduct_f194b2c1-54af-36a1-9743-5293ec4e34ae|imgt:hasExpressionSystem|imgt:_E.coli_(Escherichia_coli) imgt:IgG4-kappa_649|rdfs:label|IgG4-kappa_649 imgt:Product_b874e91f-5c72-30ea-8bd2-f0bf2e6cc591|imgt:commun_name|SAR441344 imgt:StudyProduct_ec3380df-8e7d-3c53-a53d-6d97d49448d0|imgt:hasClinicalPhase|imgt:Withdrawn imgt:Segment_33_1|imgt:hasImgtLabel|imgt:IgG4-kappa imgt:StudyProduct_57c2c1f6-5dab-34a3-8834-04a257252f25|imgt:application_type|Therapeutic imgt:LEO_pharma|rdfs:comment|France , Versailles imgt:SWITCH|rdfs:label|SWITCH imgt:IgG1-nd_271|http://semanticscience.org/resource/SIO_000291|imgt:IGHE imgt:mAb_473|imgt:inn_number|9799 imgt:Product_076eabd5-82bc-35a3-9425-216ef5fdee71|imgt:isProducedBy|imgt:Bristol-Myers_Squibb imgt:StudyProduct_3285d699-b694-3b33-b63d-0692bc62e613|rdf:type|obo:NCIT_C174271 imgt:Construct_282|obo:BFO_0000051|imgt:Segment_282_1 imgt:IgG4-lambda_915|http://semanticscience.org/resource/SIO_000291|imgt:F12 imgt:StudyProduct_9198fe52-58d2-3469-ab9e-15ced49c24a2|imgt:hasClinicalIndication|imgt:Canine_T-cell_lymphoma imgt:IgG1-kappa-8cys-drug_722|imgt:conjugated_with| deruxtecan, a camptothecin derivative imgt:Product_52fc64c1-2a77-36fe-aa33-96e1fc4732e7|imgt:commun_name|SCT-800 imgt:IGHG1_Fc_(Fragment_constant)-%5Bpeptide_14-mer-peptide_14-mer%5D2|rdfs:label|IGHG1 Fc (Fragment constant) - [peptide 14-mer - peptide 14-mer]2 _:B5718ad5d4dd230dfde5da97b11f5f373|imgt:isDecidedBy|imgt:FDA imgt:StudyProduct_c7f183f5-16c3-306a-be1d-ef45499042d2|rdf:type|obo:NCIT_C174271 imgt:IgG1-lambda_650|imgt:hasMolecularComponent|imgt:IG imgt:mAb_501|imgt:inn_number|9951 imgt:Allergic_asthma|imgt:isClinicalIndicationOf|imgt:StudyProduct_531ed619-12fb-3aa0-b519-7fdb71523fd0 imgt:Product_b5ab73f0-6a7d-349a-8fac-132c9549ca1d|imgt:commun_name|IBI318 imgt:Segment_830_2|imgt:hasImgtLabel|imgt:PEG_linker imgt:Product_293982f0-db82-3a23-94e8-ade06e297476|imgt:commun_name|C23 imgt:Product_d5c7a43f-7641-3a27-9229-c53ea60a3aff|imgt:commun_name|JNJ-56022473 imgt:Product_fb6a4cf5-bcaa-3a19-a998-f725027ec39c|imgt:commun_name|HuMax-TAC-ADC imgt:Product_a2e23bf0-95c9-3200-a6aa-aa2dfd3aad9d|imgt:isProductOf|imgt:mAb_764 imgt:StudyProduct_cb7ae197-a0ed-3f1f-933f-f7be3e2b0d51|imgt:application_type|Therapeutic imgt:IgG1-kappa-%5BscFv%5D2-lambda_1124|http://semanticscience.org/resource/SIO_000291|imgt:CTLA4 imgt:StudyProduct_bc948b67-2463-3ad7-990e-7a42c8101991|imgt:isStudyProductOf|imgt:Product_68af66eb-bd12-306b-b51f-ad26587efd5b imgt:Product_ee42c2a8-bd22-307b-8b06-6b191270e9a0|rdfs:label|Product_ee42c2a8-bd22-307b-8b06-6b191270e9a0 imgt:mAb_843|imgt:hasImgtStructureEntry|imgt:10811 imgt:IgG1-kappa_244|obo:RO_0002162|imgt:Homsap imgt:VH-VL-VH%27-VL%27-CH2-CH3_1054|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/VH-VL-VH'-VL'-CH2-CH3.png imgt:Product_8f8e07b1-0a56-3f97-8bf0-787b7edf471c|imgt:commun_name|T-DM1 imgt:IgG2-G4-kappa|imgt:construction_detail|IgG2-G4 - kappa imgt:Construct_1009|rdf:type|imgt:Construct imgt:Product_546d6daa-5d28-3e8b-9d12-ffa5d6ed0afa|imgt:isProducedBy|imgt:Aptevo_Therapeutics imgt:Acute_myocardial_infarction|rdf:type|obo:NCIT_C185637 imgt:11628|rdf:type|obo:NCIT_C25402 imgt:Product_c25395cf-d8e1-3156-8672-bccded639c93|imgt:commun_name|teprotumumab-trbw imgt:ENZ-CTP_698|obo:RO_0002162|imgt:Homsap imgt:mAb_1040|rdf:type|imgt:INN imgt:StudyProduct_f46daee3-70a0-3629-8853-470a04aad715|rdfs:label|StudyProduct_f46daee3-70a0-3629-8853-470a04aad715 imgt:V-D-J-CLUSTER|owl:sameAs|obo:SO_0000532 imgt:Localized_pustular_psoriasis_(palmoplantar_pustulosis)|rdfs:label|Localized_pustular_psoriasis_(palmoplantar_pustulosis) imgt:IgG4-kappa_30|imgt:hasConstruct|imgt:Construct_30 imgt:mAb_949|rdf:type|imgt:INN imgt:Segment_1267_1|rdf:type|imgt:Segment imgt:StudyProduct_120f87ab-86d1-3376-b725-cea0e49618a7|rdfs:label|StudyProduct_120f87ab-86d1-3376-b725-cea0e49618a7 imgt:TR-Gamma-3_Delta|rdfs:label|TR-Gamma-3_Delta imgt:ImClone_Systems_Inc|rdfs:label|ImClone Systems Inc. imgt:IgG4-kappa_802|imgt:hasConstruct|imgt:Construct_802 imgt:Product_46d6f326-70b7-314c-8914-fade9448e906|rdf:type|obo:NCIT_C51980 imgt:Product_795cef08-7412-3081-a82a-eac1a4e6d317|rdf:type|obo:NCIT_C51980 imgt:mAb_1077|imgt:hasOriginClone|imgt:Clone_1077 imgt:Segment_699_2|imgt:hasImgtLabel|imgt:XTEN imgt:StudyProduct_b446062e-05b8-397d-92a8-a54a2fb2ab92|imgt:hasClinicalPhase|imgt:Phase_M imgt:StudyProduct_6531837b-e221-3c84-b29d-98740ad35007|rdf:type|obo:NCIT_C174271 imgt:Product_8cbc64f1-a09e-3b24-8971-ec6382ae015a|rdfs:label|Product_8cbc64f1-a09e-3b24-8971-ec6382ae015a imgt:Product_e0900857-baec-3ba7-84be-9d2b0fd497c6|imgt:isProductOf|imgt:mAb_868 imgt:Product_1d8957b9-d04f-3bf2-9ecb-463987894434|rdf:type|obo:NCIT_C51980 imgt:Akero_Therapeutics|imgt:produces|imgt:Product_5fe27d5e-9dfb-3d39-8194-dd812554970a imgt:StudyProduct_21f1ceb8-4bca-39d1-b944-1b63b562e69f|imgt:isStudyProductOf|imgt:Product_75eafa99-1920-3a21-9a27-a04a05a3e0ec imgt:mAb_1060|imgt:inn_number|11336 imgt:10499|imgt:isImgtStructureEntryOf|imgt:mAb_721 imgt:StudyProduct_756a1d32-159a-3249-8937-7c086cad7559|imgt:hasDecision|_:B8c6ef4a538355935dce521d1e21d94b7 imgt:IgG2-kappa_277|imgt:hasConstruct|imgt:Construct_277 imgt:Product_8f8e07b1-0a56-3f97-8bf0-787b7edf471c|imgt:hasStudyProduct|imgt:StudyProduct_2b14bfff-9798-340b-b834-432071918ab6 imgt:Product_7a3ec779-a1bd-30e8-a7a2-4a6524b06459|imgt:isProducedBy|imgt:GlaxoSmithKline imgt:mAb_700|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=700 imgt:StudyProduct_aedffa5f-0866-31f3-b361-3e84aef3d109|imgt:hasClinicalIndication|imgt:Cancers_gastric _:B5def1e133dca274003189f38913a4003|imgt:isDecisionOf|imgt:StudyProduct_efdf3dbb-e6b7-392b-a3c4-12cc4066e98e imgt:StudyProduct_d13d1a3c-d413-3b7e-b0ac-f0bfc6d23850|imgt:hasClinicalPhase|imgt:Phase_III obo:NCIT_C2733|rdf:type|owl:Class imgt:Hematologic_malignancies|imgt:isClinicalIndicationOf|imgt:StudyProduct_443d9d1d-8da9-3091-b330-0402f6b180e3 imgt:Product_eaa50595-7c42-33fb-a33a-988a28daf176|rdf:type|obo:NCIT_C51980 imgt:StudyProduct_3a5bcbbe-2650-3d63-8ee6-27abe69c0061|rdf:type|obo:NCIT_C174271 imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_f0c8977d-e83e-3a42-b1ae-a6e1a47ee5c2 imgt:StudyProduct_539fa9d5-8ab0-3a91-a391-5578edb0fba9|rdfs:label|StudyProduct_539fa9d5-8ab0-3a91-a391-5578edb0fba9 imgt:StudyProduct_858cd827-86ef-3719-803e-875e7f111f76|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:IgG1-kappa-4cys-drug_482|rdfs:comment|IgG1 - kappa - 4cys - drug imgt:Product_710cc786-b093-3241-ad04-1d69bb1caaf0|rdf:type|obo:NCIT_C51980 imgt:IgG1-kappa_754|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:Product_c9b09440-3c97-37f9-a7a3-a051cfd3499c|imgt:isProductOf|imgt:mAb_25 imgt:Product_be140b70-fccf-3adc-ab0e-066855350e81|imgt:hasStudyProduct|imgt:StudyProduct_d326469e-6f88-3537-a40c-8ab4d0953fec imgt:mAb_888|imgt:hasProduct|imgt:Product_1d8957b9-d04f-3bf2-9ecb-463987894434 imgt:StudyProduct_567dca9c-f362-30db-b121-50386b4dbb4b|imgt:development_technology| Humanization by CDR grafting imgt:Product_770e5549-b827-3967-8e0a-db64781042be|imgt:hasStudyProduct|imgt:StudyProduct_0310809d-8412-324d-b039-dce1756572c5 imgt:renflexis®|rdf:type|obo:NCIT_C156644 imgt:StudyProduct_e910d445-dc60-3b35-a340-a22fbf4715c1|imgt:isStudyProductOf|imgt:Product_892634ba-c82f-36f9-9106-1537e1c79b28 imgt:StudyProduct_2d924b80-9cd2-391c-9954-1ac1206ab109|imgt:isStudyProductOf|imgt:Product_538ab0c9-c52c-3c61-ae4c-1c89532b23a7 imgt:Segment_1253_1|rdfs:label|Segment_1253_1 imgt:mAb_914|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=914 imgt:isStudyProductOf|rdfs:range|obo:NCIT_C51980 imgt:Construct_1109|obo:BFO_0000051|imgt:Segment_1109_1 imgt:Construct_588|obo:BFO_0000051|imgt:Segment_588_1 imgt:Product_dbe70051-84bf-318e-a2df-870d1dbb932a|rdfs:label|Product_dbe70051-84bf-318e-a2df-870d1dbb932a imgt:StudyProduct_a19c7e6d-dacb-3962-ad32-ab8dfbf103b1|imgt:development_technology| Alternative to antigen receptors domain scaffold FN1 F10, fibronectin F10 (Adnectin™) imgt:Novartis_Pharmaceuticals_Corp|imgt:produces|imgt:Product_a767bffc-a297-39f0-a375-f95be362b9e7 imgt:Construct_1033|obo:BFO_0000051|imgt:Segment_1033_1 imgt:mAb_1200|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=1200 imgt:Construct_854|obo:BFO_0000051|imgt:Segment_854_1 imgt:StudyProduct_24c7d0f6-354b-3443-a377-8958069cb8dd|rdfs:label|StudyProduct_24c7d0f6-354b-3443-a377-8958069cb8dd imgt:StudyProduct_3bfa1123-ebd5-3f43-932e-509b7c03d0cb|imgt:hasClinicalPhase|imgt:Phase_M imgt:Construct_124|imgt:isConstructOf|imgt:Fab-G2a-kappa_124 imgt:Segment_987_1|rdfs:label|Segment_987_1 imgt:Product_ad630571-be3a-37d0-b30d-5b4667c2c49a|imgt:hasStudyProduct|imgt:StudyProduct_788aba1c-003a-351a-94b2-fdb63d57c91e imgt:StudyProduct_8284c36a-a4f1-3679-8daa-5c500ee2284b|rdf:type|obo:NCIT_C174271 imgt:Product_46d6f326-70b7-314c-8914-fade9448e906|rdfs:label|Product_46d6f326-70b7-314c-8914-fade9448e906 imgt:4GW5|rdfs:label|4GW5 imgt:StudyProduct_c0feab04-ef70-3102-ad3e-c6f59586ef54|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:Product_7c524e73-547d-3b09-baca-f38148653f91|imgt:isProducedBy|imgt:GlaxoSmithKline imgt:Product_5fc9aa53-f083-3789-8cf2-ea4a5852e7d2|imgt:commun_name|exenatide imgt:mAb_263|imgt:hasBibliographicReference|pubmed:10960454 imgt:scFv-kappa-heavy-CD28_(CO-TM-CY)-CD247_827|imgt:hasConstruct|imgt:Construct_827 imgt:Product_d5c7a43f-7641-3a27-9229-c53ea60a3aff|imgt:isProductOf|imgt:mAb_754 imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_043adbe2-5122-3b2d-b5c9-7dcefb38c2c7 imgt:Construct_126|obo:BFO_0000051|imgt:Segment_126_1 imgt:mAb_479|imgt:hasProduct|imgt:Product_f0221536-d202-3194-8a6c-80a5b460de1b imgt:IgG1-kappa_149|rdfs:label|IgG1-kappa_149 imgt:StudyProduct_4495f259-8824-3877-b42f-dde6cabec1b7|imgt:hasDecision|_:Bfdd634ca00062b45f311e3dcc73f4579 imgt:mAb_927|rdf:type|imgt:INN imgt:mAb_215|imgt:clinical_trials|42 studies found, 1 recruiting imgt:StudyProduct_8e37ca13-b2e0-3906-8533-188aae9cfe08|imgt:hasClinicalIndication|imgt:Cancers_small_cell_lung_(SCLC) _:B0a671de3919995100927399c806b06df|imgt:isDecidedBy|imgt:FDA imgt:Clone_645|imgt:clone_name|ABT-806 MCB 77015BR imgt:Autoimmune_diseases_CD4_mediated|rdf:type|obo:NCIT_C185637 imgt:IGHG1_Fc_(Fragment_constant)-%5BFGF21_(fibroblast_growth_factor_21)%5D2|rdf:type|imgt:ConstructLabels imgt:Clone_864|rdf:type|obo:NCIT_C37925 imgt:nivestym|rdf:type|obo:NCIT_C156644 imgt:Segment_1038_1|imgt:has_rank|1 imgt:IgG1-lambda_1216|rdfs:label|IgG1-lambda_1216 imgt:ANGPTL3|rdf:type|obo:NCIT_C25702 imgt:StudyProduct_df7d11cb-16c1-3ba2-99fd-41d5e65148c3|imgt:hasClinicalIndication|imgt:Allergic_rhinitis imgt:Segment_296_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Product_ab1469c5-6914-33ba-a094-bef28a95f7f3|imgt:isProducedBy|imgt:UCB imgt:mAb_731|imgt:inn_proposed_list|116 (2016) imgt:mAb_1153|rdf:type|obo:NCIT_C161597 imgt:10523|rdf:type|obo:NCIT_C25402 imgt:StudyProduct_81958a90-90dc-3b31-822e-012da3e7ff76|imgt:hasExpressionSystem|imgt:_CHO-K1 imgt:Horizon_Therapeutics_plc|imgt:produces|imgt:Product_c25395cf-d8e1-3156-8672-bccded639c93 imgt:mAb_455|rdf:type|obo:NCIT_C78859 imgt:Segment_30_1|imgt:has_rank|1 imgt:StudyProduct_cfea9ae8-51dd-3e18-a195-08157b88fa72|imgt:isStudyProductOf|imgt:Product_f4c1df4f-2677-3e9d-9741-4a08b92eb031 _:B896840c02032358f107d9a350da23b4c|dc:date|2018-07-03 imgt:mAb_94|rdf:type|obo:NCIT_C95793 imgt:Idiopathic_pulmonary_fibrosis|imgt:isClinicalIndicationOf|imgt:StudyProduct_a3cc3c99-76ff-3041-8a15-26c76e38ca13 imgt:mAb_417|imgt:inn_recommended_list|69 (2013) imgt:Segment_1118_2|rdfs:label|Segment_1118_2 imgt:mAb_302|imgt:inn_proposed_list|101 (2009) _:Bfdf098c70fc2412800c67a61c047a3e6|imgt:isDecisionOf|imgt:StudyProduct_94f5337b-0646-3463-9f19-8108acffa52d _:Bfdf098c70fc2412800c67a61c047a3e6|dc:date|2016-11-09 imgt:Segment_811_1|rdfs:label|Segment_811_1 imgt:Construct_440|imgt:hasImgtLabel|imgt:IgG1-nd imgt:StudyProduct_edc037eb-991b-38b0-a754-be3ba8b8d178|imgt:application_type|Therapeutic imgt:PEG_linker|rdf:type|imgt:SegmentLabels imgt:StudyProduct_f1a2ac18-78f7-3354-a4a7-44240a5c9472|imgt:hasDecision|_:B4d0a78ec806f1311b3995982084e7187 imgt:Segment_613_3|rdfs:label|Segment_613_3 imgt:Lymphoma_follicular_(FL)|imgt:isClinicalIndicationOf|imgt:StudyProduct_a414af3e-eea8-303a-966b-5051ae5bf14b imgt:Segment_525_1|imgt:has_rank|1 imgt:StudyProduct_788aba1c-003a-351a-94b2-fdb63d57c91e|imgt:development_technology| PENTRA® stable scFv imgt:Construct_643|imgt:isConstructOf|imgt:IgG1-lambda_643 imgt:9368|rdfs:label|9368 imgt:Construct_1193|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:CEACAM5|skos:definition|CEACAM5 (carcinoembryonic antigen-related cell adhesion molecule 5, CEA, CD66e) imgt:10128|imgt:isImgtStructureEntryOf|imgt:mAb_567 imgt:Alder_Biopharmaceuticals_Inc|rdfs:label|Alder Biopharmaceuticals, Inc. obo:NCIT_C150403|rdfs:subClassOf|obo:NCIT_C1909 imgt:StudyProduct_d0967c15-4109-3f1f-b021-400633f822e0|imgt:hasClinicalIndication|imgt:Ebola_virus_infection imgt:_CHO_(Chinese_Hamster_Ovary)_MTX_(methotrexate_resistant)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_6f3ded54-f936-3d37-9f9a-66c98aaceb0f imgt:mAb_628|imgt:inn_name|cepeginterferon alfa-2b imgt:mAb_995|rdf:type|obo:NCIT_C1909 imgt:Product_e975b070-9be2-38ce-bb6e-ecee5129340b|imgt:commun_name|MEDI2452, anti-ticagrelor, antidote for ticagrelor imgt:Cancers_squamous|imgt:clinical_domain|Oncology imgt:StudyProduct_d0ef6cb1-edf4-3df0-930b-7ea881c98a95|imgt:application_type|Therapeutic imgt:StudyProduct_23e351ab-c13b-3fcd-a885-935151f0ec57|imgt:hasClinicalIndication|imgt:Acute_lymphocytic_leukemia_(ALL) imgt:StudyProduct_81102e8a-33d7-3b67-9d03-c9113452c687|rdf:type|obo:NCIT_C174271 imgt:Killer_cell_immunoglobulin-like_receptor|dc:identifier|imgt_000292 imgt:mAb_161|imgt:hasImgtStructureEntry|imgt:1L6X imgt:cpca|rdfs:label|cpca imgt:Segment_48_1|rdf:type|imgt:Segment imgt:3B2V|rdf:type|obo:NCIT_C25402 pubmed:7608568|rdfs:label|PMID_7608568 imgt:mAb_918|imgt:imgt_note| The structure is that amended in L83 recommended list. ieramilimab structure is that amended in L122 (2020). _:B19669455770995ecfb982801baea60de|dc:date|2017-07-06 imgt:Segment_673_1|obo:BFO_0000050|imgt:Construct_673 imgt:10687|rdf:type|obo:NCIT_C25402 imgt:IgG1-kappa_238|rdfs:comment|IgG1 - kappa imgt:Segment_734_1|imgt:has_rank|1 imgt:IG|rdf:type|imgt:immunoglobulin imgt:ImaginAb_Inc|rdfs:comment|Inglewood , USA imgt:StudyProduct_71619e4c-0a71-3045-8eb6-0f20fac38956|rdfs:label|StudyProduct_71619e4c-0a71-3045-8eb6-0f20fac38956 imgt:Product_16598ce5-139e-369a-9c15-ff7fed2d1f12|imgt:commun_name|PRX002 pubmed:7772562|rdfs:label|PMID_7772562 imgt:V-(VJ)-J-C-CLUSTER|owl:sameAs|obo:SO_0000566 imgt:Product_c9cd5d6c-3e39-30c7-8a4f-47103005cdcf|imgt:isProducedBy|imgt:BioVitrum imgt:H1|skos:definition|hinge exon 1 of IG heavy C-GENE-UNIT imgt:mAb_1219|imgt:inn_proposed_list|125 (2021) imgt:IgG1-kappa_754|rdf:type|imgt:MAbReceptor imgt:Product_3324747e-377b-32d2-95cf-77fa2a26537b|rdf:type|obo:NCIT_C51980 imgt:IgG1-kappa_1195|rdf:type|imgt:MAbReceptor imgt:StudyProduct_454fa2ab-d4ad-3680-9760-9da2d95eb36a|imgt:hasClinicalIndication|imgt:Coagulation_factor_VIII_deficiency_(Hemophilia_A) imgt:IL17A|imgt:isTargetOf|imgt:IgG1-kappa_428 imgt:StudyProduct_394d4b82-fd16-3fbe-809d-af59b6380eb1|imgt:hasClinicalIndication|imgt:Anemia_associated_with_HIV_infection_or_HIV_treatment imgt:scFv-heavy-kappa_173|rdfs:comment|scFv - heavy - kappa imgt:Psoriatic_arthritis_(PSA)|imgt:isClinicalIndicationOf|imgt:StudyProduct_0ae77efd-e7bd-35b3-812d-dd2e43ab1931 imgt:StudyProduct_b273692a-ef6a-35d7-84f1-c9019bdc6d3d|imgt:hasClinicalIndication|imgt:Graft-versus-host_disease_(GvHD) imgt:IgG4-kappa_1002|obo:RO_0002162|imgt:Hum imgt:Product_80543f95-22b7-3761-a574-ef4df0802d70|imgt:isProductOf|imgt:mAb_419 imgt:Clone_942|rdfs:label|Clone_942 imgt:IgG1-kappa_158|imgt:hasMolecularComponent|imgt:IG imgt:Product_c6e625a6-b97d-3e44-9c4f-6b949cd3d815|rdfs:label|Product_c6e625a6-b97d-3e44-9c4f-6b949cd3d815 imgt:Product_9b8fd23d-77df-3897-9633-83ec58c245d0|imgt:isProductOf|imgt:mAb_171 imgt:Product_7e664528-a961-3eda-8e83-9135554c8676|imgt:hasStudyProduct|imgt:StudyProduct_3779319a-f15d-31b8-81e0-940d4b89d07a imgt:Product_12be981a-d52d-3197-b2a3-b970642e0c79|rdfs:label|Product_12be981a-d52d-3197-b2a3-b970642e0c79 imgt:IgG1-kappa_201|imgt:hasConstruct|imgt:Construct_201 imgt:Construct_450|obo:BFO_0000051|imgt:Segment_450_1 imgt:StudyProduct_1158859d-da28-3dbe-974c-69b321460d2c|imgt:development_technology| VelocImmune® imgt:HSV|imgt:isTargetOf|imgt:IgG1-nd_41 imgt:mAb_708|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=708 imgt:Product_c2a35708-7257-3084-8079-8ca3bcca6373|rdfs:label|Product_c2a35708-7257-3084-8079-8ca3bcca6373 pubmed:11567989|dc:contributor|Blazar BR imgt:StudyProduct_4cdd49cd-0f02-370e-95fe-8121a698d4fe|rdfs:label|StudyProduct_4cdd49cd-0f02-370e-95fe-8121a698d4fe imgt:IgG2-kappa_929|imgt:hasConstruct|imgt:Construct_929 imgt:StudyProduct_8476d0fe-4539-3a60-bc58-985053ae3b28|rdfs:label|StudyProduct_8476d0fe-4539-3a60-bc58-985053ae3b28 imgt:IgG2-kappa_102|imgt:hasConstruct|imgt:Construct_102 imgt:StudyProduct_977172bc-a3d4-34c3-95d9-591ceea2178a|imgt:hasClinicalIndication|imgt:Hereditary_Angioedema (HAE) imgt:HCV|imgt:isTargetOf|imgt:IgG1-nd_443 imgt:mAb_866|rdf:type|obo:NCIT_C137991 imgt:StudyProduct_682c5f8a-f241-364f-866c-306cbe2cf630|imgt:isStudyProductOf|imgt:Product_546d6daa-5d28-3e8b-9d12-ffa5d6ed0afa imgt:SNP|imgt:isTargetOf|imgt:MAbReceptor_509 imgt:StudyProduct_990d9537-fad6-3727-a623-6279efbdf49a|imgt:development_technology| Abgenix's XenoMouse® imgt:StudyProduct_7df31001-106b-3fe6-bdaf-f3aa6220ebee|imgt:development_technology| POTELLIGENT® technology (afucosylation) imgt:Construct_335|obo:BFO_0000051|imgt:Segment_335_1 imgt:IgG1-kappa_544|imgt:hasMolecularComponent|imgt:IG imgt:IgG1-kappa_764|http://semanticscience.org/resource/SIO_000291|imgt:LukGH imgt:VH-CH1-IDUA|skos:definition|Iduronate 2-sulfatase IDS imgt:Product_29519aab-8c0a-3e53-8eea-8f07f4fc346a|rdfs:label|Product_29519aab-8c0a-3e53-8eea-8f07f4fc346a imgt:BioInvent|imgt:produces|imgt:Product_a3ff7a59-fdf8-3902-80b5-b75af38e0634 imgt:G-ALPHA|rdf:type|imgt:RegionLabel imgt:StudyProduct_b063c60c-7c3d-3aac-92b4-c8661305b3be|imgt:hasClinicalIndication|imgt:Cancers_prostate imgt:Solid_tumors|imgt:isClinicalIndicationOf|imgt:StudyProduct_5cf0c516-2972-37f2-ab70-2c2d6e4acfc6 imgt:mAb_1249|imgt:inn_proposed_list|126 (2022) imgt:Clone_109|rdf:type|obo:NCIT_C37925 imgt:StudyProduct_bd3a5690-76d8-3798-bc05-a5cc72b447c9|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_4bbecab0-a4f5-3260-abd9-2f615860ad76|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:FUSION-ACVR2A-GAMMA-1|rdf:type|imgt:ChainLabels imgt:StudyProduct_fe684ec5-0128-3868-a081-30f3394dcd0a|imgt:hasClinicalIndication|imgt:Atopic_dermatitis_(AD) imgt:mAb_24|imgt:inn_recommended_list|45 (2001) imgt:IgG1-kappa_502|rdf:type|imgt:MAbReceptor imgt:StudyProduct_c1f5df6a-fb42-33e0-bc04-a30586e3f522|imgt:hasDecision|_:B002dbfde80597db6f60b2c20b676da6e imgt:mAb_282|rdfs:label|mAb_282 imgt:mAb_374|rdf:type|obo:NCIT_C91728 imgt:Segment_693_1|obo:BFO_0000050|imgt:Construct_693 imgt:VH-VH%27-H-Gamma1-VL-VL%27-C-kappa_651|rdf:type|imgt:MAbReceptor imgt:hasStudyProduct|rdfs:range|obo:NCIT_C174271 imgt:Product_be7fe1ac-60ec-3e93-a36a-4383c0cb79ad|imgt:isProducedBy|imgt:Genmab_A/S imgt:Product_08b4009b-8932-3d41-9240-3bfa3c889ea0|rdf:type|obo:NCIT_C51980 imgt:Product_dafd22c1-b296-344b-a18a-fcd81228093f|imgt:hasStudyProduct|imgt:StudyProduct_2e8ffc66-8b75-3c0d-96fa-9ec9d2403912 imgt:StudyProduct_2d692d7e-dc3a-32f8-a727-40e204693160|rdfs:label|StudyProduct_2d692d7e-dc3a-32f8-a727-40e204693160 imgt:StudyProduct_1354ecba-d4cb-3ad5-88b7-04667b5f8ae4|imgt:isStudyProductOf|imgt:Product_f54c6043-6277-3c37-b202-92f1deb4aaff _:B12bfedd4c7a6ff56170de1cee88c8cc5|rdf:type|obo:NCIT_C53285 imgt:IgG1-kappa_567|obo:RO_0002162|imgt:Hum imgt:CR1_(Pr164-234)|rdfs:label|CR1 (Pr164-234) _:B1d7f6f642293fe374dbf3064f3137d51|rdf:type|obo:NCIT_C53285 imgt:Ankylosing_spondylitis_(AS)|imgt:clinical_domain|Immunology imgt:StudyProduct_ab776de0-86ac-309c-a5c0-b32486186e7f|imgt:hasClinicalIndication|imgt:Cancers_pancreatic imgt:Clone_294|imgt:isOriginCloneOf|imgt:mAb_294 imgt:complement_C3b,_C4b|imgt:isTargetOf|imgt:CPCA_PROTEIN_3REPEATS-PEPTIDE-MYRISTOYL_264 imgt:StudyProduct_b60604a6-c0b6-39bd-b7cd-e97e147dca68|imgt:development_technology| MorphoSys's HuCAL® phage library imgt:mAb_189|imgt:hasProduct|imgt:Product_b3961992-c2b9-37ee-928a-d15e7a89c880 imgt:IgG4-nd_304|obo:RO_0002162|imgt:Hum imgt:IG-Light-Kappa-IGKC|imgt:defines|imgt:IgE_Kappa imgt:IgG4-kappa_186|imgt:hasMolecularComponent|imgt:IG imgt:StudyProduct_59f65d42-b762-3ecc-91e3-5191a5c2779a|rdf:type|obo:NCIT_C174271 imgt:mAb_463|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=463 imgt:mAb_715|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=715 imgt:Segment_397_1|imgt:has_rank|1 imgt:IG-ALPHA_LAMBDA|imgt:describes|imgt:IgA_Lambda imgt:mAb_1224|imgt:hasMabReceptor|imgt:IgG1-kappa-%5BPROTEIN%5D3_1224 pubmed:17240489|dc:contributor|Niezgoda M imgt:IgG4-kappa_480|imgt:hasConstruct|imgt:Construct_480 imgt:Product_e75484d6-63ef-3d47-8150-d13346757f21|rdfs:label|Product_e75484d6-63ef-3d47-8150-d13346757f21 imgt:StudyProduct_64ae4f5a-6e22-3dd8-8377-f95cecc297c6|imgt:hasClinicalPhase|imgt:Phase_II imgt:StudyProduct_db0139c4-7901-30e0-953e-7b4d31e496e8|imgt:hasClinicalIndication|imgt:Giant_cell_arteritis imgt:Segment_466_1|rdf:type|imgt:Segment imgt:StudyProduct_21694c6c-877e-3426-8dc2-a88c164223db|imgt:hasClinicalPhase|imgt:Phase_III imgt:Construct_1271|imgt:isConstructOf|imgt:IgG1-kappa_1271 imgt:Construct_69|imgt:isConstructOf|imgt:MAbReceptor_69 imgt:StudyProduct_4784e7fe-8ef2-3b5d-82a9-2a04b89fe5ff|rdfs:label|StudyProduct_4784e7fe-8ef2-3b5d-82a9-2a04b89fe5ff imgt:mAb_996|imgt:hasProduct|imgt:Product_c4bc2033-a7b8-33b5-bffe-c1764f721429 imgt:Segment_1299_1|obo:BFO_0000050|imgt:Construct_1299 imgt:Construct_242|imgt:isConstructOf|imgt:Fab%27-G1-kappa-PEG-PEG_242 imgt:H-CH2-CH3|rdf:type|imgt:ChainLabels imgt:StudyProduct_bee8e0d7-239d-3f40-882c-e26a3de7e64c|rdfs:label|StudyProduct_bee8e0d7-239d-3f40-882c-e26a3de7e64c imgt:StudyProduct_02122574-90c0-3f84-9e7a-48bd2a464e48|rdf:type|obo:NCIT_C174271 imgt:ICAM1|rdfs:label|ICAM1 obo:NCIT_C107678|rdf:type|owl:Class imgt:StudyProduct_39fabc0f-de7a-3eb0-a3aa-bc74ad2aa805|imgt:isStudyProductOf|imgt:Product_f272da3d-d319-39ce-a72e-2eaf8b604878 imgt:IgG1-kappa_1016|http://semanticscience.org/resource/SIO_000291|imgt:APP imgt:PROTEIN_1DOMAIN_1291|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/PROTEIN_1DOMAIN.png imgt:Segment_1074_1|imgt:has_rank|1 imgt:StudyProduct_3641cbab-419b-324f-882f-719f12d8073d|imgt:hasClinicalPhase|imgt:Phase_I imgt:Segment_553_1|obo:BFO_0000050|imgt:Construct_553 imgt:FAB-GAMMA_KAPPA|imgt:describes|imgt:Fab-Gamma_Kappa imgt:Product_7ebb6d25-c5d0-3d40-bc0d-6012f24de5cb|imgt:hasStudyProduct|imgt:StudyProduct_f0bb64ec-247d-3b83-98b3-2abb3f314a67 imgt:Product_8f4bc0b9-33eb-3dac-aba0-4e658471c39a|imgt:isProductOf|imgt:mAb_504 imgt:StudyProduct_d13463ab-484e-3b47-821a-63605119d127|imgt:isStudyProductOf|imgt:Product_9f3b70a8-1ab1-357c-82db-a284346f9860 imgt:Product_d0b4ae6d-7aac-3e07-ba48-06ade646cf35|imgt:isProductOf|imgt:mAb_704 pubmed:1346155|dc:contributor|Beverley PC imgt:Product_2f33022b-bbc0-3f59-bc75-86deb8919d2c|rdfs:label|Product_2f33022b-bbc0-3f59-bc75-86deb8919d2c imgt:Product_feba6bcf-b6af-3f3b-bb5a-1ac0b3da5702|imgt:isProductOf|imgt:mAb_1243 imgt:StudyProduct_4885c462-bdd8-3ecc-8e8c-51aef23a087a|imgt:hasClinicalPhase|imgt:Phase_I imgt:StudyProduct_81927165-cf24-379f-bd6f-871335b30244|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:Product_ccaee58d-d4c1-3c86-90f0-df9bb7bf2ae1|imgt:hasStudyProduct|imgt:StudyProduct_40e1a270-5276-3064-a146-8993d30876bc imgt:Segment_1083_1|imgt:hasImgtLabel|imgt:half-IG_G1-kappa/(scFv-kappa-heavy)-h-CH2-CH3 imgt:MAbReceptor_513|rdf:type|imgt:MAbReceptor imgt:Carcinoma_bladder_cancer_advanced_or_metastatic_urothelial_cancers|imgt:isClinicalIndicationOf|imgt:StudyProduct_3f9bd427-1ccd-3281-9c05-1b70fead3c8d imgt:StudyProduct_bc96394e-4266-3b0c-9ff1-ec9e290b0e3f|imgt:development_technology| MorphoSys's HuCAL® phage library imgt:9572|rdfs:label|9572 imgt:StudyProduct_b61f946d-b608-3531-851b-b002dcaad596|imgt:hasClinicalPhase|imgt:Phase_III imgt:StudyProduct_731650cb-173c-3766-9a69-c1690558868d|rdfs:label|StudyProduct_731650cb-173c-3766-9a69-c1690558868d imgt:IgG1-kappa-1cys_N84.4-drug_1072|imgt:conjugated_with| pyrrolobenzodiazepine (PDB) dimer SG3199 imgt:mAb_614|imgt:hasMabReceptor|imgt:IgG4-nd_614 imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_c44937d5-47d6-3303-a118-7b724d88dc14 imgt:StudyProduct_e156aa64-974c-3c8b-b484-c306fbda3c82|imgt:application_type|Therapeutic imgt:Product_65ff39db-abc8-3fea-a44b-33c9a2a782e2|rdf:type|obo:NCIT_C51980 imgt:StudyProduct_16d8d743-6f76-3228-86d8-fdfad4ae7eae|rdf:type|obo:NCIT_C174271 imgt:Construct_175|obo:BFO_0000051|imgt:Segment_175_1 imgt:Product_75f84b83-eb14-3a03-a9e0-3efba822c52f|rdfs:label|Product_75f84b83-eb14-3a03-a9e0-3efba822c52f imgt:9956|rdf:type|obo:NCIT_C25402 imgt:IgG1-nd_45|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-nd.png imgt:Autoimmune_diseases|imgt:isClinicalIndicationOf|imgt:StudyProduct_c5774158-3f34-39b3-9850-003a4415fb21 imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_50ee47ba-842f-362d-a090-229570dec725 imgt:Product_37e454ae-c400-32fb-913e-b064fbf26cc6|imgt:isProducedBy|imgt:Roche_F_Hoffmann-La_Roche_Ltd imgt:mAb_365|imgt:hasProduct|imgt:Product_a8c8c8c2-d189-3ad8-a6d9-9c8f8d8c89c0 imgt:StudyProduct_82596810-73a4-3823-92ab-f261c6581d9e|rdfs:label|StudyProduct_82596810-73a4-3823-92ab-f261c6581d9e _:B6005b15c6cea0ef5b1dafd2c054c3af0|dc:date|2016-05-18 imgt:Product_4a23c8ba-9b9e-3cbe-84e7-42b7b0592cc2|imgt:hasStudyProduct|imgt:StudyProduct_c4cda74f-687e-35cb-9659-ec7d4f939431 imgt:Product_63e4e4b4-5918-3eef-818c-291c25f73777|imgt:commun_name|hAFP-31 imgt:FG-STRAND|skos:definition|strand of RPI-PreB-Light-V (previously VpreB) from codon position 105, according to the IMGT unique numbering imgt:IgG1-kappa_590|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:StudyProduct_3fd941bf-0663-37c6-81e0-47e586d03fba|imgt:isStudyProductOf|imgt:Product_94ff4548-cf82-3333-b651-af7954d824c6 imgt:FAB-GAMMA-2_KAPPA|rdf:type|imgt:StructureLabels imgt:IgG1-kappa-4lys-drug_387|obo:RO_0002162|imgt:Hum imgt:StudyProduct_980c504c-20da-34f2-8e0d-9812491b4e8b|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_03b7ff0f-2d1f-3a11-b8bd-d1b049ee566b|rdf:type|obo:NCIT_C174271 imgt:Segment_1251_1|rdfs:label|Segment_1251_1 _:Bcd9192a8cf3512af9e97006b6c415b4a|rdf:type|obo:NCIT_C53285 imgt:mAb_534|imgt:inn_recommended_list|74 (2015) imgt:mAb_951|imgt:inn_name|gatralimab imgt:J-GENE-UNIT|rdf:type|imgt:PrototypeUnitLabel imgt:Product_b3961992-c2b9-37ee-928a-d15e7a89c880|rdf:type|obo:NCIT_C51980 imgt:PROTEIN_1DOMAIN_626|http://semanticscience.org/resource/SIO_000291|imgt:IFNAR2 https://doi.org/10.1038/332323a0|dc:date|1988 imgt:CStone_Pharmaceuticals|imgt:produces|imgt:Product_b156ff03-19c7-34f8-b3a7-b189635f031d imgt:Product_0c5fb596-41fb-3ab4-bbc2-3ab6a19b5b7e|imgt:isProducedBy|imgt:Baxter_BioScience imgt:Product_c4526586-07f1-3afc-81e7-ecabc79a2f1c|imgt:hasStudyProduct|imgt:StudyProduct_e3b079bc-4e67-356b-800d-4abbf31ae8da imgt:L-V-D-sequence|skos:definition|Identifies, for cDNA, molecule entities with a leader L region, a rearranged V region and a partially_rearranged D. L-V-D-sequence is in partially_rearranged configuration. imgt:IgG4-kappa_353|obo:RO_0002162|imgt:Hum imgt:Construct_778|obo:BFO_0000051|imgt:Segment_778_1 imgt:IgG1-lambda_468|http://semanticscience.org/resource/SIO_000291|imgt:IL23A imgt:Product_a3222722-cf6b-3189-8b44-5c791cff2a5e|imgt:hasStudyProduct|imgt:StudyProduct_6446a6bb-8e94-3aa4-a30b-6012ac3ebd2c imgt:V-J-REGION|skos:definition|coding region of an IG or TR that comprises V-REGION and J-REGION, in rearranged gDNA or cDNA imgt:CD3E|imgt:isTargetOf|imgt:IgG4-lambda_894 imgt:11741|rdf:type|obo:NCIT_C25402 imgt:Segment_1198_1|obo:BFO_0000050|imgt:Construct_1198 imgt:StudyProduct_28be0a14-2fba-3773-b625-52940c25b0b8|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:Segment_111_1|rdfs:label|Segment_111_1 imgt:StudyProduct_e74e6492-ccee-3cfe-984b-10204f242972|rdf:type|obo:NCIT_C174271 imgt:tetra-specific|skos:definition|tetra-specific imgt:VARIATION|skos:definition|a related population contains stable mutations _:B75893a7cc7ec2b4d9dbd8d1731674bfe|dc:date|2021-05-26 imgt:Segment_413_2|imgt:hasImgtLabel|imgt:peptide_19-mer imgt:11341|imgt:isImgtStructureEntryOf|imgt:mAb_1061 imgt:Construct_143|rdf:type|imgt:Construct imgt:IgG1-kappa-4cys-drug_645|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa-4cys-drug.png imgt:mAb_367|imgt:inn_number|9382 imgt:Segment_220_1|obo:BFO_0000050|imgt:Construct_220 imgt:Product_cf2f7fdd-756d-34db-a0a8-796cf3a5e368|imgt:commun_name|anti-CCR2 imgt:composite_protein_for_clinical_applications|skos:definition|Identifies genetically engineered proteins other than FPIA that result from the fusion of peptide, region and/or domain of protein(s) of different sources, or from the fusion of peptide, region and/or domain of protein(s) to a chemical or biochemical agent. The Fc may be present and used as a transporter or to increase the product half-life but, not for its effector properties that are rather avoided. imgt:CD19|imgt:isTargetOf|imgt:IgG1-kappa-4cys-drug_493 imgt:GFRA3|skos:definition|GFRA3 (glial cell derived neurotrophic factor family receptor alpha 3, GFRa-3) imgt:StudyProduct_b5218a57-f488-3ad3-a582-544b8b2e8bdd|imgt:isStudyProductOf|imgt:Product_747d2bfa-44b6-3feb-95ae-81e3134044b6 imgt:TR-Gene|rdfs:subClassOf|imgt:Gene imgt:StudyProduct_7c608379-7a72-3348-bbf8-0b597847afa4|imgt:application_type|Therapeutic imgt:FPIA_FC-%5BPROTEIN%5D2_824|rdfs:label|FPIA_FC-[PROTEIN]2_824 imgt:mAb_177|imgt:hasMabReceptor|imgt:IgG1-kappa_177 imgt:Clone_939|imgt:clone_name|11A11 imgt:StudyProduct_f15e7be9-4088-3ea1-affb-249aa21b583e|imgt:isStudyProductOf|imgt:Product_5c0aac93-e5ec-3675-b1ef-16f7fbe485d4 imgt:Construct_931|rdfs:label|Construct_931 imgt:StudyProduct_ed93c1fc-3057-3d2e-be34-06ab0de17375|imgt:hasClinicalIndication|imgt:Rheumatoid_arthritis_(RA) imgt:scFv-kappa-heavy-CD3E_(CO-TM-CY)_1300|imgt:fused_with| CD3E (CO-TM-CY) (1:1) imgt:StudyProduct_3c2e8c1b-f3e7-3e3d-a63e-6d7ce37909f2|rdfs:label|StudyProduct_3c2e8c1b-f3e7-3e3d-a63e-6d7ce37909f2 imgt:Product_18e218fa-ac0d-39a4-9e01-9513fbb2bc7c|imgt:hasStudyProduct|imgt:StudyProduct_08ede5e9-5468-3e28-ab2c-a7204ea416e6 imgt:mAb_1203|rdf:type|obo:NCIT_C184814 imgt:mAb_562|imgt:hasMabReceptor|imgt:IgG4-kappa_562 imgt:IgG4-lambda2_780|obo:RO_0002162|imgt:Homsap imgt:Construct_720|rdfs:label|Construct_720 imgt:West_Nile_Virus_Infection|rdf:type|obo:NCIT_C185637 imgt:PROTEIN_1DOMAIN_997|imgt:hasMolecularComponent|imgt:RPI imgt:Autoimmune_diseases|imgt:isClinicalIndicationOf|imgt:StudyProduct_d216a0b8-7a7d-3879-acc2-f980a11469c4 imgt:Segment_849_1|obo:BFO_0000050|imgt:Construct_849 imgt:Prothena_Therapeutics_Limited|imgt:produces|imgt:Product_54cab23f-6842-36f6-8c63-d59c7c94aa01 imgt:StudyProduct_2a63f436-c3f9-30bd-a295-2e53a5ab32b6|imgt:hasDecision|_:Be450e76d9eddf001e85c62036d157c3f imgt:Segment_954_1|imgt:hasImgtLabel|imgt:IgG2-kappa imgt:StudyProduct_cb0b76f8-27a2-333e-ab9e-fcea851900a9|rdf:type|obo:NCIT_C174271 imgt:THPO|rdfs:label|THPO imgt:mAb_1283|rdf:type|imgt:INN imgt:Product_b353bcb4-76c4-3d6a-8bca-4d0445e74563|imgt:isProducedBy|imgt:River_Vision_Development_Corp imgt:Segment_961_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:StudyProduct_ca2e917d-4310-3324-a891-cf35fce0d42a|imgt:development_technology| Chimeric antigen receptor (CAR) T cell engineering imgt:Cancers_small_cell_lung_(SCLC)|imgt:isClinicalIndicationOf|imgt:StudyProduct_8e37ca13-b2e0-3906-8533-188aae9cfe08 imgt:D-GENE|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/IMGTScientificChart/SequenceDescription/Prototypes/D-gene.png imgt:StudyProduct_5f4b56c5-0c22-3e10-b1fa-52d055ad6dc3|imgt:application_type|Therapeutic imgt:mAb_398|imgt:hasMabReceptor|imgt:CARRIER_BIG-8PEPTIDE_398 imgt:FAB-GAMMA-2_KAPPA|imgt:describes|imgt:Fab-Gamma-2_Kappa imgt:Segment_283_1|rdf:type|imgt:Segment imgt:Scotgen_Biopharmaceuticals_Ltd|imgt:produces|imgt:Product_38c1a25f-e60f-3814-8e5d-126ee6596548 imgt:mAb_77|imgt:hasMabReceptor|imgt:IgG1-kappa_77 imgt:Construct_1061|obo:BFO_0000051|imgt:Segment_1061_1 imgt:StudyProduct_58fd01ed-11b1-3d24-b0db-8844bb814951|imgt:hasDecision|_:B1f894a17c2d729d8c73a10da58b43dc4 imgt:mAb_861|imgt:clinical_trials|3 studies found, 1 recruiting imgt:scFv-TR_798|obo:RO_0002162|imgt:Hum imgt:Segment_815_1|rdfs:label|Segment_815_1 imgt:StudyProduct_90fd282e-02f9-398a-be74-6e57271986c8|imgt:application_type|Therapeutic imgt:Product_d897727a-4fb2-3eb1-99b5-48e3b1af7b74|rdf:type|obo:NCIT_C51980 imgt:Segment_1026_1|rdfs:label|Segment_1026_1 imgt:StudyProduct_ea630399-3539-32a6-b42c-18836fbb512f|imgt:hasDecision|_:B37cdd411cfa15c38113bc3e96183f02b imgt:mAb_782|rdf:type|imgt:INN imgt:Segment_268_1|rdf:type|imgt:Segment imgt:StudyProduct_e6322b3d-2a73-354e-bd52-2f8428dc5628|rdf:type|obo:NCIT_C174271 imgt:Cancers_breast|imgt:isClinicalIndicationOf|imgt:StudyProduct_9878e289-bc08-301c-8250-fdcad2c3f6e1 imgt:CEACAM8|imgt:isTargetOf|imgt:IgG1-kappa_MM_258 imgt:Product_49c2056b-e4db-3d7e-aeaa-1e329f6571e9|imgt:commun_name|VEGF Trap R1/R2 imgt:mAb_447|imgt:inn_proposed_list|108 (2012) imgt:Product_80543f95-22b7-3761-a574-ef4df0802d70|rdf:type|obo:NCIT_C51980 imgt:FPIA_%5BPROTEIN%5D2-FC_1227|imgt:via_a| peptidyl linker imgt:IgG4-kappa_385|rdfs:label|IgG4-kappa_385 imgt:StudyProduct_bf390145-1da6-3243-8c8b-6e1b025d646b|rdf:type|obo:NCIT_C174271 _:Baf91dc8e7e1b1254942600806eb8f275|imgt:hasDesignation|imgt:Orphan_drug imgt:StudyProduct_24f7a218-01dc-3469-b000-c47934d7f395|imgt:hasClinicalIndication|imgt:Musculoskeletal_diseases _:B6a407e496338df091af9dc7952bf9587|dc:date|2015-04-24 imgt:Construct_830|obo:BFO_0000051|imgt:Segment_830_3 imgt:mAb_47|imgt:hasProduct|imgt:Product_bf674d94-88de-356e-8f92-90585d0c6453 imgt:HOR-CTP_696|rdfs:label|HOR-CTP_696 imgt:StudyProduct_5fdbf507-352c-34e8-a0b0-00c7a6c7863e|imgt:hasClinicalIndication|imgt:Age-related_macular_degeneration_(AMD)_neovascular_(wet) imgt:HOR-CTP_696|http://semanticscience.org/resource/SIO_000291|imgt:FSHR imgt:mAb_928|imgt:imgt_note| nadunolimab INN name is the one amended in L122 (2020) (in replacement of nidanilimab \r (L120))\r imgt:Product_b9a738f9-5b22-38f9-848f-e3ea2ee2b97d|imgt:isProducedBy|imgt:Amgen imgt:Product_091f169d-1ad9-3a1e-b6a8-3a2da0e1e7be|imgt:isProducedBy|imgt:NIH _:B730b829d1aa5b6bd27b58cc4ca3e839d|rdf:type|obo:NCIT_C53285 imgt:TR-Delta-TRD|rdf:type|imgt:ChainType imgt:StudyProduct_3d9c8b9c-4fa4-3ef1-b3cf-ea6581c2bab5|imgt:isStudyProductOf|imgt:Product_b0734cf2-486f-3853-a05a-854676784ad9 imgt:Segment_819_1|obo:BFO_0000050|imgt:Construct_819 imgt:Segment_64_1|rdfs:label|Segment_64_1 imgt:Construct_744|rdf:type|imgt:Construct imgt:StudyProduct_ffeb1ca9-c9e8-34f6-83ea-618ca732e826|imgt:hasClinicalIndication|imgt:Spinal_muscular_atrophy_(SMA) imgt:Construct_100|obo:BFO_0000051|imgt:Segment_100_1 imgt:mAb_398|imgt:imgt_note| CRM197 is a non-toxic mutant of diphtheria toxin having a single amino acid change (G77E77) (Giannini, G. et al. Nucleic Acids Res. 12: 4063-4069 (1984)) used as a vaccine carrier. An average of 15 DAEFRHD peptides (Homo sapiens APP (amyloid beta A4 precursor protein) Abeta 1-7 (Pr672-678) (P05067)), are conjugated to the N6 of lysyl of the diphtheria toxin mutant CRM197 via a Cys-S-CH2-CO- linker (patent US8227403). imgt:StudyProduct_df2cfb74-301d-31c5-871c-e021350b02af|rdfs:label|StudyProduct_df2cfb74-301d-31c5-871c-e021350b02af imgt:StudyProduct_755c9b10-ee5e-3939-ad41-4f1df088cebf|rdf:type|obo:NCIT_C174271 imgt:mAb_1252|imgt:hasProduct|imgt:Product_b874e91f-5c72-30ea-8bd2-f0bf2e6cc591 imgt:StudyProduct_07c2f5c9-d098-3e2a-aeda-aface4f5a09a|imgt:hasDecision|_:B4e136a2dc204982f9b0f16221164035b imgt:StudyProduct_38193ef7-7070-3608-ab5c-cd67e024d8b4|imgt:hasClinicalPhase|imgt:Phase_II imgt:StudyProduct_4b21c329-c5c3-3710-8846-4c5dde09005d|imgt:hasClinicalIndication|imgt:prevention_of_feto-maternal_allo-immunization_in_RhD-_women imgt:IgG1-kappa_1125|obo:RO_0002162|imgt:Hum imgt:Construct_525|rdf:type|imgt:Construct imgt:IgG4-kappa_1037|rdfs:comment|IgG4 - kappa imgt:Clone_143|rdfs:label|Clone_143 imgt:IgG1-kappa_653|rdf:type|imgt:MAbReceptor imgt:IgG1-kappa_727|imgt:hasConstruct|imgt:Construct_727 imgt:Construct_507|imgt:isConstructOf|imgt:IgG3-kappa_507 imgt:StudyProduct_4adb7627-2f8a-3ff1-97fd-04fe49ec7aaf|imgt:isStudyProductOf|imgt:Product_703c4b0d-f69e-3fe3-b385-600d9224c3b0 imgt:Product_295d81a6-22b0-3a10-a52e-d3ea9fcfd5cc|imgt:isProducedBy|imgt:AstraZeneca imgt:11074|imgt:isImgtStructureEntryOf|imgt:mAb_1011 imgt:Product_4433004c-0bcd-33f3-9da4-91b8cdbb1e11|imgt:comercial_name|BYDUERON® (formulated for extended release) _:B392ebcb0c317439525a7eafafa5228e7|rdf:type|obo:NCIT_C53285 imgt:Construct_611|imgt:isConstructOf|imgt:FPIA_%5BPROTEIN-PROTEIN-PROTEIN-PROTEIN%5D2-3S-FC_611 imgt:mAb_1125|imgt:inn_name|domvanalimab imgt:StudyProduct_74f1b671-4c30-3723-8c9c-a70f5e224310|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_61d8846d-a4ae-3443-98e5-3e742149cd7e|imgt:hasClinicalPhase|imgt:Phase_III _:Bf5f9e1d11b9cccfd4a947b180d1f26b0|dc:date|2013-02-22 imgt:Sanofi_Genzyme|imgt:produces|imgt:Product_f7538e81-df8d-3950-8fd5-c3ef71a52d77 imgt:IgG4-kappa_962|rdf:type|imgt:MAbReceptor imgt:StudyProduct_d76e18ea-00be-3b61-9daa-04b219b160a5|imgt:hasClinicalIndication|imgt:Autoimmune_diseases imgt:Segment_1243_1|obo:BFO_0000050|imgt:Construct_1243 imgt:StudyProduct_9a60d879-ca3e-3b3e-a03f-a1228692b419|imgt:hasClinicalIndication|imgt:Melanoma pubmed:18088084|dc:contributor|Moreno M imgt:StudyProduct_3b28e052-b149-35bf-89f9-79a5d320a5e5|rdf:type|obo:NCIT_C174271 pubmed:7719381|dc:date|1994 imgt:IgG2b-nd_318|rdfs:label|IgG2b-nd_318 _:Bdbfa4eab4338662016ff4008fd8c1b46|rdf:type|obo:NCIT_C53285 imgt:THPO|rdf:type|imgt:ChainLabels imgt:Construct_439|rdfs:label|Construct_439 imgt:IgG4-kappa_1066|rdfs:label|IgG4-kappa_1066 _:Bffb174c0029bcf5602565acb5985027f|imgt:isDecidedBy|imgt:FDA imgt:StudyProduct_b9617fc0-a404-3cff-ac56-94d20bcda253|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_e32291ae-4c12-389d-9d34-49b8592b09c1|rdf:type|obo:NCIT_C174271 imgt:Aratana_Therapeutics_Inc|rdf:type|obo:NCIT_C54131 imgt:StudyProduct_6a75c3c7-fd9d-3d13-ba55-34265317c29e|rdf:type|obo:NCIT_C174271 imgt:(DJ)-C-CLUSTER|owl:sameAs|obo:SO_0000539 imgt:Construct_851|imgt:hasImgtLabel|imgt:IgG4-kappa imgt:Construct_169|obo:BFO_0000051|imgt:Segment_169_1 imgt:Wyeth_Pharmaceuticals|imgt:produces|imgt:Product_79c48f1c-e47e-37e0-a142-44132cbf3ead imgt:Segment_537_1|obo:BFO_0000050|imgt:Construct_537 imgt:CD15|rdfs:label|CD15 imgt:Construct_626|rdf:type|imgt:Construct imgt:Product_b156ff03-19c7-34f8-b3a7-b189635f031d|rdf:type|obo:NCIT_C51980 imgt:StudyProduct_daf7b05a-33d0-3ddc-b2fe-426e50aa94f0|rdfs:label|StudyProduct_daf7b05a-33d0-3ddc-b2fe-426e50aa94f0 pubmed:27144973|dc:contributor|Champion T imgt:Segment_952_1|imgt:has_rank|1 imgt:CH1-CH2-CH3|skos:definition|CH1, CH2 and CH3 C-DOMAINs from an IG-HEAVY (H) chain imgt:mAb_772|rdfs:label|mAb_772 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imgt:StudyProduct_3e1d78de-8b1a-3505-9158-cc499ec854f7|imgt:hasClinicalIndication|imgt:Non-Hodgkin's_lymphoma_(NHL) imgt:LCN1|rdfs:label|LCN1 imgt:IgG1-lambda_1254|rdfs:label|IgG1-lambda_1254 imgt:Graft-versus-host_disease_(GvHD)_acute|rdf:type|obo:NCIT_C185637 imgt:scFv-scFv-scFc_kappa-lambda_1058|imgt:hasConstruct|imgt:Construct_1058 imgt:mAb_950|imgt:hasImgtStructureEntry|imgt:11182 imgt:Systemic_lupus_erythematosus_(SLE)|imgt:isClinicalIndicationOf|imgt:StudyProduct_f433b026-1e29-33a9-9131-6f46a3a38d76 imgt:StudyProduct_18a6f88b-127f-31d2-8cc4-dba82ee281b8|imgt:application_type|Therapeutic imgt:StudyProduct_f4e82d7a-070a-369a-8823-f63259da2a80|imgt:hasClinicalIndication|imgt:IL6_dependent_tumors imgt:IgG1-kappa_1280|obo:RO_0002162|imgt:Hum imgt:Product_8e166e12-e4cd-38db-b446-f13906a4421c|imgt:commun_name|NY-ESO-1(c259) T cells imgt:StudyProduct_9b776a72-b4b4-3ba1-a388-578f88a5c8f4|imgt:isStudyProductOf|imgt:Product_a6d81985-8457-3c64-8479-7deb8f3f5b22 _:B498051079d4ffc3cda571e154479d74a|rdf:type|obo:NCIT_C53285 imgt:mAb_1234|rdfs:label|mAb_1234 imgt:Clone_290|imgt:isOriginCloneOf|imgt:mAb_290 imgt:Construct_1208|rdf:type|imgt:Construct imgt:CEACAM6|rdf:type|obo:NCIT_C25702 imgt:Fab-G1-TOXIN_BIG-kappa_65|imgt:hasMolecularComponent|imgt:IG imgt:IgG1-kappa_648|rdf:type|imgt:MAbReceptor imgt:ACE2|rdf:type|imgt:ChainLabels imgt:StudyProduct_64df6f56-9ee1-3540-ae4c-8f714b5cdb93|imgt:hasClinicalIndication|imgt:Anaplastic_large_cell_lymphoma_(ALCL) imgt:EGFR|imgt:isTargetOf|imgt:IgG1-kappa_601 _:Ba8eb01a5bb73f2cc03d792c66725b686|dc:date|2012-08-03 _:B50701193709f0a41a9b97b84a5831b15|imgt:isDecisionOf|imgt:StudyProduct_76ed5004-fdcf-3c32-b93d-ddd111280196 imgt:CONSERVED-TRP|rdfs:label|CONSERVED-TRP _:Bb230751bbca6a2e2e4d0be0e85ad3499|imgt:hasStatut|imgt:approval imgt:mAb_938|rdf:type|obo:NCIT_C174768 imgt:StudyProduct_54944a58-885e-3faa-910e-36c9c4a047ee|imgt:hasClinicalIndication|imgt:Solid_tumors imgt:Segment_624_1|obo:BFO_0000050|imgt:Construct_624 imgt:StudyProduct_5bf07078-f944-3783-a9d0-7c0a5f117457|imgt:isStudyProductOf|imgt:Product_f67bf612-c97e-3f7e-9be7-c3022bf8d1b1 imgt:StudyProduct_0624898a-43cb-3fa7-8d95-9e20c8b17fc2|imgt:application_type|Therapeutic imgt:StudyProduct_d24549d2-16af-3305-88f2-6445585bd19e|rdfs:label|StudyProduct_d24549d2-16af-3305-88f2-6445585bd19e imgt:IgG1-lambda_535|imgt:hasConstruct|imgt:Construct_535 imgt:StudyProduct_a209289d-05ee-34a5-9eef-2f615f32282f|rdf:type|obo:NCIT_C174271 obo:NCIT_C175761|rdfs:subClassOf|obo:NCIT_C1909 imgt:Homozygous_familial_hypercholesterolemia_(HoFH)|imgt:isClinicalIndicationOf|imgt:StudyProduct_2d5ce8c9-7700-3e05-b6c2-4d613c31d3ce imgt:Construct_953|rdf:type|imgt:Construct imgt:BioAtla_LLC|imgt:produces|imgt:Product_65d1338b-2af9-3814-ae94-b94de9579065 imgt:StudyProduct_d558635e-1973-3755-bebf-a99aa4f23859|imgt:hasClinicalIndication|imgt:Cancers_prostate imgt:Product_36bd5910-6476-3d77-8be5-4b3d6257ff28|rdfs:label|Product_36bd5910-6476-3d77-8be5-4b3d6257ff28 imgt:StudyProduct_e76dd271-b84f-3aaf-b1f8-6154e72d3c61|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells _:Bf018bf15633d9895aae192b2aac23f77|dc:date|2013-03-12 imgt:Segment_676_1|rdfs:label|Segment_676_1 imgt:StudyProduct_8505d214-61a7-36c8-aac5-edc87bb68d36|imgt:application_type|Therapeutic imgt:Age-related_macular_degeneration_(AMD)_neovascular_(wet)|imgt:isClinicalIndicationOf|imgt:StudyProduct_1b5cf8e3-aa2f-38ba-b7e3-e35fff725897 imgt:G1-kappa_scFv-h-CH2-CH3_1083|http://semanticscience.org/resource/SIO_000291|imgt:bispecific imgt:Construct_652|obo:BFO_0000051|imgt:Segment_652_1 imgt:StudyProduct_f3528446-9dbe-35b3-aba1-d8c499415651|rdf:type|obo:NCIT_C174271 imgt:Segment_1263_1|rdf:type|imgt:Segment imgt:Product_affb4612-ed19-303a-8dab-ddb3e270a308|imgt:commun_name|MM-141 imgt:mAb_285|imgt:imgt_note| sibrotumab INN definition is the one amended in L86 (2002) and R48 (2002). imgt:Product_4391f6b4-98b1-38e2-94d2-967326f820fe|imgt:isProducedBy|imgt:Merck_&_Co_Inc imgt:MSLN|imgt:isTargetOf|imgt:IgG1-lambda-1lys-drug_938 imgt:StudyProduct_628cc4c4-33ab-343b-b095-6c6b7cde48d8|imgt:application_type|Therapeutic imgt:mAb_77|imgt:clinical_trials|181 studies found, 23 recruiting imgt:Clone_213|rdf:type|obo:NCIT_C37925 _:Bbfd0e82b4e0e7d12cb558a2f00b9eeec|imgt:hasDesignation|imgt:Orphan_drug imgt:IG-MU_IOTA|imgt:describes|imgt:IgM_Iota imgt:Product_ceb3912e-1a2a-3355-bb97-cead13a7b3ac|imgt:hasStudyProduct|imgt:StudyProduct_b99c5ced-585d-3c4f-8398-9f413b697d87 obo:NCIT_C156644|skos:definition|A biological product that is highly similar in structure and function to, and has no clinically meaningful differences from, an FDA-approved reference product. [ NCI ] imgt:VH-VH-VH_trivalent|rdfs:label|VH - VH' - VH, trivalent imgt:mAb_1290|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=1290 imgt:StudyProduct_48b01d58-4c5f-3786-a0ab-fcd7e0038c42|imgt:hasClinicalIndication|imgt:Atopic_dermatitis_(AD) imgt:StudyProduct_a779018f-4c09-321d-a9a5-bcd91e3cf91f|imgt:isStudyProductOf|imgt:Product_9e85a06f-cc89-31ca-b689-1be2820b0536 imgt:MAbReceptor_50|imgt:hasMolecularComponent|imgt:IG imgt:mAb_748|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=748 imgt:Canlupfam_MS4A1|imgt:isTargetOf|imgt:IgG2-kappa-lambda_2bridges_593 imgt:StudyProduct_5f55bb4c-1cfa-326f-81b0-c75e55a0f285|imgt:hasClinicalPhase|imgt:Phase_M imgt:11452|imgt:isImgtStructureEntryOf|imgt:mAb_1080 imgt:Rheumatoid_arthritis_(RA)|imgt:isClinicalIndicationOf|imgt:StudyProduct_91c9ac2b-c058-3172-8668-dba24e6176a0 pubmed:1279672|dc:contributor|Murphy B.R. imgt:StudyProduct_a353023d-9680-3092-ac3d-9ddb5fe4e986|rdfs:label|StudyProduct_a353023d-9680-3092-ac3d-9ddb5fe4e986 imgt:Product_b18c7489-8c67-32b7-93b0-4b6452620c97|imgt:comercial_name|ANTHIM® imgt:mAb_799|imgt:hasMabReceptor|imgt:IgG1-kappa_799 imgt:scFv-heavy-kappa-CD28_(CO-TM-CY)-CD247_876|http://semanticscience.org/resource/SIO_000291|imgt:CD19 https://doi.org/10.1073/pnas.95.2.669|rdfs:label|https://doi.org/10.1073/pnas.95.2.669 imgt:StudyProduct_c9cb9aa6-0e00-3387-9b2f-cf4c47721430|imgt:application_type|Therapeutic imgt:StudyProduct_4cd327d5-becb-33b0-9063-1b4d45383724|imgt:hasDecision|_:Ba5a12cb103757e091531982f7bfa1442 imgt:mAb_1076|imgt:hasProduct|imgt:Product_7a38b45b-74e0-3f52-a6b0-b61adec57f6e imgt:CH1|rdfs:label|CH1 imgt:VEGFA|imgt:isTargetOf|imgt:MAbReceptor_179 imgt:Product_68a891fa-4b0b-330d-bdcf-7ec104ae102a|imgt:isProducedBy|imgt:Genentech_Inc imgt:10881|rdf:type|obo:NCIT_C25402 imgt:mAb_1147|rdf:type|imgt:INN imgt:mAb_855|imgt:imgt_note| In 2007, the compound was licensed to United Therapeutics by Memorial Sloan-Kettering Cancer Center. imgt:Product_8a665ccb-3040-3133-a43c-0685bb662383|imgt:hasStudyProduct|imgt:StudyProduct_fdd929a4-c6ab-30d1-b1b7-b7989a4e7187 imgt:mAb_490|imgt:hasProduct|imgt:Product_a7b373c0-f329-3b03-b24e-41f48c77a159 imgt:Segment_704_2|imgt:segment_detail|1-133 imgt:IgG1-nd-%5BPROTEIN%5D2_254|rdf:type|imgt:MAbReceptor imgt:3HR5|imgt:isImgtStructureEntryOf|imgt:mAb_406 imgt:IgG4-kappa_578|imgt:hasMolecularComponent|imgt:IG imgt:StudyProduct_daa460c0-2d80-38a1-8f51-9450d40a9c07|imgt:isStudyProductOf|imgt:Product_812d634c-7fc4-326e-970f-a2903b3aed65 imgt:Product_6fff76bc-baa0-3e3c-9cf8-839e804eb2ac|rdf:type|obo:NCIT_C51980 imgt:StudyProduct_e7755a61-bc17-385d-8e2e-53e84a96dc04|imgt:application_type|Therapeutic imgt:Segment_386_1|obo:BFO_0000050|imgt:Construct_386 imgt:Clone_1130|imgt:isOriginCloneOf|imgt:mAb_1130 imgt:IgG1-kappa_330|imgt:isMabReceptorOf|imgt:mAb_330 imgt:Bristol-Myers_Squibb|imgt:produces|imgt:Product_3c3fcf8d-d19d-34ce-b042-90ea8dff0aa9 imgt:Product_406390c3-6cd8-3629-be68-66016fce19cf|imgt:comercial_name|TECENTRIQ® imgt:Recurrent_respiratory_papillomatosis_vaccine_(RRP)|imgt:isClinicalIndicationOf|imgt:StudyProduct_e96ded07-239f-343d-ac18-db63ba41c6cf imgt:Bone_marrow_scintigraphy|imgt:clinical_domain|Osteology imgt:Segment_1039_1|rdfs:label|Segment_1039_1 imgt:11413|rdfs:label|11413 imgt:mAb_1242|rdf:type|obo:NCIT_C1909 imgt:exendin-4_a_39_amino_acid_GLP1_mimetic_|imgt:construction_detail|exendin-4, a 39 amino acid GLP1 mimetic imgt:Segment_1232_1|obo:BFO_0000050|imgt:Construct_1232 imgt:PROTEIN_1DOMAIN-PEG_871|imgt:hasMolecularComponent|imgt:RPI imgt:StudyProduct_24fa3620-291b-3955-8b31-b5da695a14d9|imgt:development_technology| Triomab® (Trifunctional Ab) imgt:StudyProduct_380b9cf3-3dc6-38d6-955b-eb3e19145a38|rdfs:label|StudyProduct_380b9cf3-3dc6-38d6-955b-eb3e19145a38 imgt:StudyProduct_b3b612e4-41f9-337f-bd0c-b96a4d51f3e6|rdf:type|obo:NCIT_C174271 imgt:Arteriovenous_fistula|imgt:isClinicalIndicationOf|imgt:StudyProduct_9b665b77-8b00-371a-98f7-bca97c3efb08 imgt:Construct_285|obo:BFO_0000051|imgt:Segment_285_1 imgt:Product_5a490e25-bdeb-3fc5-b45d-f7095463e64a|rdf:type|obo:NCIT_C51980 imgt:mAb_857|rdf:type|obo:NCIT_C170268 imgt:IL13RA1|rdf:type|obo:NCIT_C25702 imgt:IgG2-kappa_467|imgt:hasMolecularComponent|imgt:IG pubmed:1873503|dc:contributor|Maeda H imgt:mAb_836|rdfs:label|mAb_836 imgt:Construct_311|imgt:isConstructOf|imgt:IgG1-nd_311 imgt:FN_(fibronectin)|imgt:isTargetOf|imgt:%5BscFv-kappa-heavy-PROT%5D2_796 imgt:G1-K-L_with_domain_crossover2_952|http://semanticscience.org/resource/SIO_000291|imgt:CD3E imgt:StudyProduct_5bcedbe7-b055-3c97-a226-8d981827ea23|rdf:type|obo:NCIT_C174271 imgt:isChainInStruct|rdfs:subPropertyOf|obo:BFO_0000050 imgt:IgG2-kappa_332|imgt:hasConstruct|imgt:Construct_332 imgt:mAb_764|rdf:type|imgt:INN imgt:Fab-G1-lambda_1191|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/Fab-G1-lambda.png imgt:StudyProduct_470fba3c-c13f-3b6a-b2a8-d44d7213ccc6|rdfs:label|StudyProduct_470fba3c-c13f-3b6a-b2a8-d44d7213ccc6 faldo:location|rdfs:comment|This is the link between the concept whose location you are annotating and its range or position. For example, when annotating the region that describes an exon, the exon would be the subject and the region would be the object of the triple or: 'active site' 'location' [is] 'position 3'. imgt:IgG4-kappa_402|imgt:hasConstruct|imgt:Construct_402 imgt:9746|rdf:type|obo:NCIT_C25402 imgt:Glioblastoma_multiforme_(GBM)|imgt:clinical_domain|Oncology _:B7f47b72c1b79d1b263a5c5e16e873c21|rdf:type|obo:NCIT_C53285 imgt:Segment_131_1|rdf:type|imgt:Segment imgt:Product_70626d7d-afcd-3d0c-944a-b65990e20e32|imgt:hasStudyProduct|imgt:StudyProduct_4b310d9f-8117-369c-83fa-2873787eda90 imgt:Product_4a210fe1-cd13-31c5-a0f8-83e6e6417a4d|imgt:hasStudyProduct|imgt:StudyProduct_3342649c-c1cd-3781-8614-9586a241a1de imgt:StudyProduct_f4807e52-f39a-3b92-ad82-f3540c8f3fcc|rdf:type|obo:NCIT_C174271 _:B002dbfde80597db6f60b2c20b676da6e|rdf:type|obo:NCIT_C53285 imgt:mAb_861|imgt:hasImgtStructureEntry|imgt:10291 imgt:StudyProduct_4e03a35f-639e-3c28-925a-2505a32230fa|rdfs:label|StudyProduct_4e03a35f-639e-3c28-925a-2505a32230fa imgt:Product_60d50ddc-7055-3124-936b-1628e2af1236|imgt:hasStudyProduct|imgt:StudyProduct_0fca7506-9287-3470-a77f-f57284843269 imgt:IgM_Iota|imgt:isDefinedBy|imgt:IG-Light-Iota-IGI _:B8ca398a0824e7a0ec4900c3b0c15658d|imgt:hasStatut|imgt:approval obo:NCIT_C171025|rdf:type|owl:Class imgt:IgG1-nd_MM_305|rdfs:label|IgG1-nd_MM_305 imgt:StudyProduct_6a3d73b1-d98e-3a7a-a499-079a203ad53f|imgt:isStudyProductOf|imgt:Product_9cefcc4e-84ab-3c12-a0f3-3b8d369271d8 imgt:CD19|imgt:isTargetOf|imgt:IgG1-kappa_MM_282 imgt:G-DomainLabel|skos:definition|MH characteristic groove domain corresponding to domain 1 or domain 2 of a MHC-I Alpha chain imgt:B_cell_leukemia|imgt:clinical_domain|Hematology imgt:Product_aaf2e2c9-1c88-3eed-ab99-9dbe7332094a|imgt:hasStudyProduct|imgt:StudyProduct_f33538ee-d425-33fe-9782-223318090985 imgt:isFunctionalityTypeOf|rdfs:label|isFunctionalityTypeOf imgt:StudyProduct_dda793a3-6153-3e67-8e8c-30c859b184ba|imgt:isStudyProductOf|imgt:Product_27f3c39d-c940-36e9-b77b-b5638fb484c9 imgt:Crohn's_disease_(CD)|imgt:isClinicalIndicationOf|imgt:StudyProduct_6bde1980-495c-3cc6-ad93-882c2bb2a125 imgt:mAb_616|imgt:hasBiosimilar|imgt:fulphila™ _:B6ececc0777daf44de38865b59a7ad5c3|dc:date|2018-09-13 imgt:StudyProduct_38d44c39-7af5-3adc-bd30-2bc14412d098|imgt:isStudyProductOf|imgt:Product_b56a0a91-0ec2-3116-b9e9-bcb59a009ed9 imgt:Clone_1071|rdf:type|obo:NCIT_C37925 imgt:Product_d7c83c7a-94a0-330e-98d7-6d98bcc47c31|imgt:hasStudyProduct|imgt:StudyProduct_2008f384-31a8-376e-b845-ed89359b18eb imgt:PSI|rdf:type|imgt:IntegrinDomainLabel imgt:5ICZ|rdfs:label|5ICZ imgt:PDL_(Protein_Design_Labs)_BioPharma|imgt:produces|imgt:Product_1e6dcbf5-881e-3dae-a9c2-c7d5ca5aaceb imgt:Clone_1017|imgt:clone_name|E143192 imgt:Product_69aca6bd-b362-373e-98be-9f1735773595|rdfs:label|Product_69aca6bd-b362-373e-98be-9f1735773595 imgt:mAb_1185|imgt:hasProduct|imgt:Product_76a068f8-e304-3746-aabc-b40c1b23f548 imgt:Construct_548|rdf:type|imgt:Construct imgt:Product_88568e72-96c0-305a-a89f-24f789162533|imgt:commun_name|0.5beta imgt:_Adenovirus_transformed_human_embryonic_293_kidney_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_be02d32a-6ad4-379d-9706-be3394ebebfc imgt:mAb_1099|imgt:inn_number|11372 _:B284beb791538b6a82503002e3ba2edb0|imgt:isDecidedBy|imgt:FDA imgt:Product_269943d5-585d-3935-924a-367a035801fc|imgt:commun_name|IPH2102 imgt:StudyProduct_a5efddc8-bf21-3fc9-987f-11778f5c8a4b|imgt:isStudyProductOf|imgt:Product_c48dacde-0411-3136-a504-67d0e67b07e5 imgt:Non-alcoholic_steatohepatitis_(NASH)|imgt:isClinicalIndicationOf|imgt:StudyProduct_18202ff2-6df9-3d9a-8f0d-e4c7b4ac3a88 imgt:StudyProduct_71af956f-bf2b-35b7-aff8-5a8adf09bfd5|imgt:hasClinicalIndication|imgt:Carcinoma_esophageal imgt:Product_2de293bd-1023-3307-9fbd-5af2cf15c7e6|rdf:type|obo:NCIT_C51980 obo:NCIT_C153379|rdf:type|owl:Class imgt:StudyProduct_f498a1e3-3991-390f-9004-c1d353f32e45|imgt:hasClinicalPhase|imgt:Phase_M imgt:IFNL1_(Pr26-200)|skos:definition|Interferon lambda-1 imgt:mAb_161|imgt:centerwatch_link|http://www.centerwatch.com/drug-information/fda-approvals/drug-details.aspx?DrugID=349 _:B95b3ec67f85abfc4a110404b5ccd7584|imgt:isDecisionOf|imgt:StudyProduct_9d6939c7-c15c-3d8d-99a8-995f6f32275b imgt:StudyProduct_5fdbf507-352c-34e8-a0b0-00c7a6c7863e|imgt:isStudyProductOf|imgt:Product_49c2056b-e4db-3d7e-aeaa-1e329f6571e9 imgt:Product_cd47e1b0-c5b3-3b90-8d93-b3ae11351271|rdf:type|obo:NCIT_C51980 imgt:IgG4-kappa_30|http://semanticscience.org/resource/SIO_000291|imgt:TNF imgt:Product_abdc580d-8408-3e32-b850-2b01e4fac11e|imgt:commun_name|HX-008 imgt:Product_7c524e73-547d-3b09-baca-f38148653f91|imgt:isProductOf|imgt:mAb_397 imgt:Construct_770|rdfs:label|Construct_770 imgt:mAb_258|imgt:inn_name|besilesomab imgt:mAb_325|imgt:hasImgtStructureEntry|imgt:4I77 imgt:mAb_947|imgt:hasProduct|imgt:Product_3adee3e6-6ae0-336d-9a0a-2290f3ed968a imgt:mAb_1047|rdfs:label|mAb_1047 imgt:IgG1-kappa_605|imgt:hasConstruct|imgt:Construct_605 imgt:Product_40d4733b-8629-353c-8086-ad4391678aa1|imgt:isProducedBy|imgt:Sanofi imgt:StudyProduct_d4930ea7-e483-3038-bacf-0735e7e036b9|rdfs:label|StudyProduct_d4930ea7-e483-3038-bacf-0735e7e036b9 imgt:Product_93e98daf-0377-30bc-900c-0e4a06d486e6|rdfs:label|Product_93e98daf-0377-30bc-900c-0e4a06d486e6 imgt:CD3E_CO|rdfs:label|CD3E CO imgt:mAb_268|imgt:inn_number|8371 imgt:mAb_510|rdfs:label|mAb_510 imgt:mAb_756|rdf:type|imgt:INN obo:NCIT_C166535|rdf:type|owl:Class imgt:Product_55f62e0c-5feb-32b7-8886-a382d130f9e5|imgt:commun_name|C21/AL-90 imgt:Construct_871|imgt:isConstructOf|imgt:PROTEIN_1DOMAIN-PEG_871 imgt:Construct_348|rdf:type|imgt:Construct imgt:Segment_1072_1|imgt:has_rank|1 imgt:StudyProduct_fe684ec5-0128-3868-a081-30f3394dcd0a|imgt:hasClinicalPhase|imgt:Phase_M imgt:StudyProduct_7027cb45-d588-3eb7-b1c2-d35ec6045bee|rdfs:label|StudyProduct_7027cb45-d588-3eb7-b1c2-d35ec6045bee imgt:Product_a49e9411-d64f-353e-8cfd-d09ad10a15b3|rdfs:label|Product_a49e9411-d64f-353e-8cfd-d09ad10a15b3 _:B76767247e151e450783ea7b94c8bff9a|dc:date|2013-09-13 imgt:10415|imgt:isImgtStructureEntryOf|imgt:mAb_660 imgt:Segment_101_1|imgt:hasImgtLabel|imgt:(scFv-kappa-heavy)-(scFv-heavy-kappa) imgt:StudyProduct_bc9039b6-a991-3026-9681-be607e9c780f|imgt:development_technology| Abgenix's XenoMouse® imgt:Pseudomonas_aeruginosa_infections|imgt:clinical_domain|Infectiology imgt:mAb_136|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=136 imgt:FPIA_%5BPROTEIN_4REPEATS%5D2-FC_245|imgt:hasMolecularComponent|imgt:FPIA imgt:N-GLYCOSYLATION-MOT|skos:definition|codons encoding a potential N glycosylation motif 'NXS/T' where N is asparagine (Asn), X any amino acid except proline (Pro), S is serine (Ser) and T is threonine (Thr) 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imgt:StudyProduct_d6cefc3d-2955-31a9-afcd-f0958bd1bc33|imgt:application_type|Therapeutic imgt:Mycoisis_fungoides_(MF)_or_Sezary_syndrome|rdfs:label|Mycoisis_fungoides_(MF)_or_Sezary_syndrome imgt:StudyProduct_16b4fdbf-25a6-39d1-b1ff-1c7c5fd66558|imgt:isStudyProductOf|imgt:Product_98a3e0f3-b097-3350-b298-3d2f113181b0 imgt:11438|rdfs:label|11438 imgt:IgG1-kappa_806|rdfs:label|IgG1-kappa_806 imgt:StudyProduct_977172bc-a3d4-34c3-95d9-591ceea2178a|rdfs:label|StudyProduct_977172bc-a3d4-34c3-95d9-591ceea2178a imgt:Deep_dermal_burn|rdfs:label|Deep_dermal_burn imgt:Product_8924fb04-237b-37c3-b29a-712a10fcde39|imgt:hasStudyProduct|imgt:StudyProduct_1884c1fa-e53a-3bd2-b507-eae4c4c1906e imgt:Product_13102177-fed1-3bec-b2c9-e3fb445321a6|imgt:isProducedBy|imgt:Amgen imgt:mAb_541|rdf:type|obo:NCIT_C162565 imgt:Product_12e83c22-d0d4-30c2-8197-cc9eececef54|imgt:comercial_name|PEG-Intron imgt:StudyProduct_06fd172d-5ef0-37ef-b7d6-510186e45fe8|imgt:hasClinicalPhase|imgt:Phase_III imgt:StudyProduct_89a7f282-c155-362c-89f9-8467980d2e13|imgt:hasClinicalPhase|imgt:Phase_M imgt:Product_4d3d1c57-c33d-3fb9-a04f-cdb7a0a344c2|imgt:hasStudyProduct|imgt:StudyProduct_e8e9aa02-1ddd-3bb4-b892-b06c80a33155 imgt:Primary_cutaneous_anaplastic_large_cell_lymphoma_(pcALCL)|imgt:isClinicalIndicationOf|imgt:StudyProduct_6fa2687b-6915-3b16-86ac-2b3309cc6cbc imgt:ganglioside_GD2_(disialoganglioside_GD2)|imgt:isTargetOf|imgt:IgG1-kappa_890 imgt:Product_3ac0b998-f720-388a-bb51-08f38d12f3e9|imgt:commun_name|BI-655130 imgt:mAb_1260|rdfs:label|mAb_1260 imgt:mAb_652|rdfs:label|mAb_652 imgt:mAb_591|rdfs:label|mAb_591 _:Bc1cf83efd6feea521c6382273d2d88a0|dc:date|2000-05-29 imgt:Behçet's_disease|rdf:type|obo:NCIT_C185637 imgt:IgG4-kappa_579|obo:RO_0002162|imgt:Chi imgt:10845|imgt:isImgtStructureEntryOf|imgt:mAb_860 imgt:Product_d8a5ae73-24a6-3fa8-9ce9-ad6827deda46|imgt:isProducedBy|imgt:RemeGen_Ltd imgt:StudyProduct_6b612b11-5933-3c77-871a-d835dd207209|imgt:hasClinicalIndication|imgt:Cancers_colorectal_(CRC)_metastatic imgt:Construct_1287|obo:BFO_0000051|imgt:Segment_1287_1 imgt:Product_788b3959-d5c8-36a5-9cf6-738181181b51|imgt:hasStudyProduct|imgt:StudyProduct_ff4e41a3-1c2c-36b3-ac2f-4ab669824935 imgt:StudyProduct_08052363-0619-3302-8aaf-cbb9ae61123b|imgt:hasClinicalIndication|imgt:Glioblastoma_multiforme_(GBM) imgt:mAb_785|imgt:hasMabReceptor|imgt:IgG2-kappa_785 imgt:PROTEIN_1DOMAIN-PEG_681|imgt:isMabReceptorOf|imgt:mAb_681 imgt:Asthma_severe_persistent|rdf:type|obo:NCIT_C185637 imgt:IgG1-kappa_1025|http://semanticscience.org/resource/SIO_000291|imgt:TNFRSF18 _:Bf479f4ea80977b614e157cdf51bae9df|imgt:isDecisionOf|imgt:StudyProduct_bf0cd894-a287-36d5-984b-c18865106b8b imgt:Product_fe4306e4-ad4c-324d-ba52-29c03d3c653f|imgt:commun_name|BCD-100 imgt:Construct_870|imgt:isConstructOf|imgt:FPIA_%5BPROTEIN_3REPEATS%5D2-3S-FC_870 imgt:IG-ALPHA-1_KAPPA|skos:definition|IG receptor comprising two H-ALPHA-1 and two L-KAPPA chains imgt:chromosome-number|skos:definition|chromosome number for a locus obo:NCIT_C157632|rdf:type|owl:Class imgt:StudyProduct_e7d55985-d5f8-3eb2-98ae-964a79e5b78a|rdfs:label|StudyProduct_e7d55985-d5f8-3eb2-98ae-964a79e5b78a imgt:FAB-EPSILON_KAPPA|rdf:type|imgt:IGProteolyticFragmentLabel _:Bea4461d890dad0a49529337d08fe84fc|imgt:isDecisionOf|imgt:StudyProduct_4c7d8465-fbea-35ea-9d44-671f41f5066e imgt:IgG1-nd_437|imgt:hasMolecularComponent|imgt:IG imgt:IgG1-kappa_365|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:StudyProduct_d09bb3d6-e5ad-3a18-a0be-17b78e4b532d|imgt:isStudyProductOf|imgt:Product_8e8a1379-1ce0-3a6f-bd30-ded74b8a8b53 imgt:F(AB%27)2-GAMMA-2B_LAMBDA|skos:definition|F(ab')2 comprising the VH-CH1 domains from two H-GAMMA-2B chains and two L-LAMBDA chains imgt:mAb_1121|imgt:inn_recommended_list|86 (2021) imgt:StudyProduct_dd88f5dd-8d77-3766-9219-118b017a5fe6|imgt:application_type|Therapeutic imgt:Construct_757|imgt:hasImgtLabel|imgt:IgG4-kappa _:Be32b0109c9ce611945111e06c20e8d81|imgt:hasStatut|imgt:approval imgt:10792|imgt:isImgtStructureEntryOf|imgt:mAb_816 imgt:IgG1-kappa-4cys-drug_432|imgt:hasMolecularComponent|imgt:IG _:Bc5ac2ff12db8d7f8c961845d821b81fd|rdf:type|obo:NCIT_C53285 imgt:IgG1-kappa_422|imgt:hasConstruct|imgt:Construct_422 _:B6f08e6f29b2920b4a97aa5a2e843cc03|imgt:hasStatut|imgt:approval imgt:Product_116668fd-8e29-3f7a-bcf8-aed5bb915412|imgt:commun_name|SAR-440340 imgt:mAb_811|rdfs:label|mAb_811 _:B8e79c126X2D6d5bX2D43a1X2Db15eX2Dd57703d05b66|rdf:first|imgt:variable_lymphocyte_receptor imgt:mAb_637|imgt:inn_recommended_list|70 (2013) imgt:Bharat_Serums_and_Vaccines|imgt:produces|imgt:Product_07665b8f-c82c-38d0-a61a-3c526b0a1864 imgt:mAb_81|imgt:inn_proposed_list|85 (2001) imgt:Construct_726|rdfs:label|Construct_726 imgt:StudyProduct_5624363e-78e2-3e7b-afa8-ec4db4f58f2c|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_c0747058-c28c-31fa-8364-f8475c60a950|rdfs:label|StudyProduct_c0747058-c28c-31fa-8364-f8475c60a950 imgt:Lymphoma|imgt:isClinicalIndicationOf|imgt:StudyProduct_3c1e5518-5900-3b45-8c8e-375084cd177e imgt:IgG4-kappa_649|imgt:hasConstruct|imgt:Construct_649 imgt:mAb_828|rdfs:label|mAb_828 imgt:Product_b5c12b2c-3e4c-373e-aa68-cadfb8ccd5f9|imgt:hasStudyProduct|imgt:StudyProduct_b5c12b2c-3e4c-373e-aa68-cadfb8ccd5f9 imgt:Segment_427_1|rdfs:label|Segment_427_1 imgt:StudyProduct_ec2f5df8-b54e-3653-b607-6340e37bc48d|imgt:isStudyProductOf|imgt:Product_3b793d72-27bf-3ae0-b582-2743a3690ff8 imgt:Construct_292|obo:BFO_0000051|imgt:Segment_292_1 imgt:9672|imgt:isImgtStructureEntryOf|imgt:mAb_450 imgt:StudyProduct_e2e85e71-8474-3ca4-819d-c7d2a030d59b|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:Clone_1276|imgt:clone_name|OST-cp33I-cp01 imgt:11435|rdf:type|obo:NCIT_C25402 imgt:StudyProduct_01c02561-34f0-3864-a55d-2a07cc089cc1|imgt:application_type|Therapeutic imgt:StudyProduct_c4649a4e-c99c-3539-9c34-17152c87eed9|imgt:development_technology| ADAPTIR™ Monospecific Platform imgt:Product_ca415bf9-d43d-31ef-b23e-bec5b4023720|rdfs:label|Product_ca415bf9-d43d-31ef-b23e-bec5b4023720 imgt:mAb_1208|rdfs:label|mAb_1208 imgt:IgG1-kappa_17|rdfs:label|IgG1-kappa_17 imgt:Product_d36a428f-9dba-35e2-8218-e0fcf61cbc77|rdfs:label|Product_d36a428f-9dba-35e2-8218-e0fcf61cbc77 imgt:9320|rdfs:label|9320 imgt:Renal_cell_carcinoma_(RCC)|rdfs:label|Renal_cell_carcinoma_(RCC) imgt:Segment_382_1|rdf:type|imgt:Segment imgt:mAb_1204|rdf:type|imgt:INN _:B8bef2fb76481b53e270919aff7344a0f|dc:date|2014-12-05 imgt:_CHOK1SV_(expresses_glutamine_synthetase_(GS)_endogenously)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_fd173d87-866b-3b0c-b0d9-dab607b1ea40 imgt:10625|imgt:isImgtStructureEntryOf|imgt:mAb_773 imgt:mAb_156|imgt:hasBibliographicReference|pubmed:10597336 imgt:mAb_1286|imgt:inn_name|trontinemab imgt:Osteoarthritis_(OA)|imgt:isClinicalIndicationOf|imgt:StudyProduct_43525a2e-523a-3dea-b23c-8fc2305b960a imgt:StudyProduct_595f5bf0-a48b-356e-b374-0db449f1b3ab|rdfs:label|StudyProduct_595f5bf0-a48b-356e-b374-0db449f1b3ab imgt:mAb_493|imgt:hasOriginClone|imgt:Clone_493 imgt:StudyProduct_58678f51-0a37-3e2e-8a7d-244f41be4b0b|imgt:hasExpressionSystem|imgt:_E.coli_(Escherichia_coli) imgt:ENZ_1DOMAIN_688|imgt:hasMolecularComponent|imgt:RPI imgt:StudyProduct_01c02561-34f0-3864-a55d-2a07cc089cc1|rdf:type|obo:NCIT_C174271 imgt:V-GAMMA|rdf:type|imgt:ChainLabels _:B982117911a172e91108746fe7bd190a4|imgt:isDecidedBy|imgt:FDA imgt:ANGPT2|rdfs:label|ANGPT2 imgt:mAb_754|imgt:inn_recommended_list|79 (2018) imgt:H-GAMMA-IFNA2|rdf:type|imgt:ChainLabels imgt:Clone_955|rdf:type|obo:NCIT_C37925 imgt:Segment_75_1|obo:BFO_0000050|imgt:Construct_75 imgt:StudyProduct_175feb57-cfac-34ae-9b82-f9d393da7ca5|rdfs:label|StudyProduct_175feb57-cfac-34ae-9b82-f9d393da7ca5 imgt:StudyProduct_16d4da35-58bb-399a-894b-7f3c3443aab9|imgt:hasClinicalIndication|imgt:Solid_tumors imgt:mAb_1186|rdf:type|obo:NCIT_C184875 imgt:Construct_194|rdf:type|imgt:Construct pubmed:1762576|rdf:type|bibo:Article imgt:IgG1-kappa_1036|obo:RO_0002162|imgt:Hum imgt:mAb_220|imgt:hasOriginClone|imgt:Clone_220 imgt:mAb_246|imgt:hasProduct|imgt:Product_bfb4b102-cf74-3ddd-b981-5824b1904091 imgt:StudyProduct_d008548d-93e9-3d46-80d4-fb8a78ec2641|imgt:hasExpressionSystem|imgt:_CHO_DG44_(Chinese_Hamster_Ovary)_cells imgt:StudyProduct_718e4f65-6a77-3775-9d84-c6a27e912ff4|rdfs:label|StudyProduct_718e4f65-6a77-3775-9d84-c6a27e912ff4 imgt:StudyProduct_ce2a9107-8d5c-351f-b0b8-b0e9eb71adbd|imgt:hasClinicalIndication|imgt:Solid_tumors imgt:mAb_1082|imgt:hasMabReceptor|imgt:IgG4-kappa_1082 imgt:StudyProduct_7e9d00bc-70f2-3776-8f14-a9921319ae5a|rdf:type|obo:NCIT_C174271 imgt:8716|rdfs:label|8716 imgt:Segment_915_1|obo:BFO_0000050|imgt:Construct_915 imgt:mAb_1239|imgt:hasImgtStructureEntry|imgt:11926 imgt:mAb_618|imgt:imgt_note| AMG334 inhibits the activity of CGRP by targeting its receptor, which is believed to transmit signals to cause the pain associated with migraine. imgt:D-gene|rdfs:label|D-gene imgt:LRRC32|obo:RO_0002162|imgt:Homsap imgt:Product_1d35d4a7-3f31-3f7c-bb34-858d027ec0c4|imgt:hasStudyProduct|imgt:StudyProduct_f0584b44-5114-35c4-99cf-ae4976aab7be _:Bb427c7b85958342383426bae618fa630|imgt:isDecisionOf|imgt:StudyProduct_b967370f-7324-3cbd-ae31-63047f764182 imgt:FPIA_%5BPROTEIN_2REPEATS%5D2-FC_895|imgt:hasConstruct|imgt:Construct_895 imgt:mAb_1205|rdf:type|obo:NCIT_C184860 imgt:mAb_30|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=30 imgt:StudyProduct_4c23fda2-e0e0-3183-b219-38ccf5fe3866|rdfs:label|StudyProduct_4c23fda2-e0e0-3183-b219-38ccf5fe3866 imgt:mAb_356|imgt:clinical_trials|3 studies found, 1 recruiting imgt:Construct_1207|rdf:type|imgt:Construct imgt:9653|rdf:type|obo:NCIT_C25402 imgt:F(ab%27)2-nd-nd_207|imgt:hasMolecularComponent|imgt:IG imgt:Product_90f4823e-5cb9-333f-bd91-f83046626483|imgt:commun_name|AMG 181 imgt:mAb_354|imgt:hasOriginClone|imgt:Clone_354 imgt:INTEGRIN-ALPHA-IIB_BETA-3|rdfs:label|INTEGRIN-ALPHA-IIB_BETA-3 imgt:StudyProduct_731650cb-173c-3766-9a69-c1690558868d|imgt:application_type|Therapeutic imgt:Product_c545816c-e16f-3035-a4bc-97ae27507d0d|imgt:isProducedBy|imgt:Sanofi imgt:mAb_832|imgt:inn_proposed_list|124 (2020) imgt:Construct_589|rdfs:label|Construct_589 imgt:Product_69aca6bd-b362-373e-98be-9f1735773595|imgt:commun_name|hBF5(H37L_L4M) imgt:Segment_1156_1|rdfs:label|Segment_1156_1 imgt:via_a|rdf:type|owl:AnnotationProperty imgt:Product_12bb60ec-d709-3f8e-b1fa-e45ee68fca8d|imgt:commun_name|G-CSF-HAS imgt:StudyProduct_8520474f-a705-3f52-b54e-4a6a92032f13|rdf:type|obo:NCIT_C174271 imgt:Renal_cell_carcinoma_(RCC)|imgt:isClinicalIndicationOf|imgt:StudyProduct_a779018f-4c09-321d-a9a5-bcd91e3cf91f imgt:frizzled_family_receptor_(FZD)|rdfs:label|frizzled family receptor (FZD) imgt:StudyProduct_333df381-8e4d-3f9f-ad92-9e329e8a5721|rdfs:label|StudyProduct_333df381-8e4d-3f9f-ad92-9e329e8a5721 imgt:CPCA_%5BPROTEIN_BIG%5D2-FC_395|imgt:fused_with| Homo sapiens IGHG1 Fc (Fragment constant) imgt:Product_24c6dba9-1e5b-3f62-b5bf-177ab7254a6b|imgt:commun_name|IMA-638 imgt:Product_80c5a255-5aa4-3782-9556-7a0618ee7c39|imgt:commun_name|ER-004 imgt:mAb_115|imgt:inn_proposed_list|70 (1993) imgt:mAb_380|imgt:imgt_note| Generation and characterization of ixekizumab are described in Liu et al. J Inflamm Res. 2016 Apr 19;9:39-50. PMID:27143947 Human antibody derived from phage display human antibody library by guided selection.This technology involved a series of selections of human VH and VL by pairing them with the VH and VL of a mouse antibody (Jespers LS et al. 1994. PMID:7521646). For D2E7, the starting mouse antibody was anti-hTNF MAK 195 (hybridoma, ECACC 87 050801). The resulting VH and VL from the Cambridge Antibody Technology (CAT) human antibody phage display library were finally fused with human IGHG1 and IGKC constant region to obtain the human mAb D2E7.D2E7 was discovered through a collaboration between BASF Bioresearch Corporation (Worcester, Massachusetts) and Cambridge Antibody Technology, then developed by BASF Knoll (BASF Pharma) and marketed by Abbott Laboratories after the acquisition of BASF Pharma by Abbott and, since January 2013 by Abbvie Inc. Adalimumab is the first human antibody approved by the FDA, in 2002. 6nov is the 3D structure of the ixekizumab Fab. imgt:Mycoisis_fungoides_(MF)_or_Sezary_syndrome|imgt:isClinicalIndicationOf|imgt:StudyProduct_45395883-2901-3e12-bb1e-90fa192cf97a imgt:Construct_850|imgt:isConstructOf|imgt:IgG4-kappa_850 imgt:Product_6bc1d7d7-3572-3445-908f-a32d9aa7218d|imgt:hasStudyProduct|imgt:StudyProduct_ca74b2ab-9fdc-32f2-be20-efd735882d1b imgt:8888|rdfs:label|8888 imgt:StudyProduct_b36541b6-ed7b-3042-8d5d-b27eb1b0b96a|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:G1-kappa_scFv-h-CH2-CH3_1075|http://semanticscience.org/resource/SIO_000291|imgt:biparatopic imgt:IgG2-lambda_924|imgt:isMabReceptorOf|imgt:mAb_924 imgt:mAb_649|imgt:hasOriginClone|imgt:Clone_649 imgt:Product_950458ce-5b79-3a87-87fd-0d76107f13a3|imgt:hasStudyProduct|imgt:StudyProduct_3f2d80b8-b738-3fba-9f6c-3c1808748d52 imgt:Product_d3f3fc46-b4d3-3454-a1c7-97eae9e1a634|imgt:hasStudyProduct|imgt:StudyProduct_b29f4dc1-8aa0-3662-989e-415c06c97bf5 imgt:Segment_1028_1|rdf:type|imgt:Segment obo:NCIT_C161597|rdfs:subClassOf|obo:NCIT_C1909 _:B17b55de5399efbc86eea66f248de90c6|imgt:hasStatut|imgt:approval imgt:J-C-SEQUENCE|skos:definition|germline cDNA including J- and C-REGION (J-C-REGION in spliced cDNA, J-REGION, J-C-INTRON, and C-REGION in unspliced cDNA) imgt:Segment_1203_1|rdf:type|imgt:Segment imgt:Product_a22e1e73-39c4-3d58-810c-61a5fe2f2b92|imgt:hasStudyProduct|imgt:StudyProduct_551f1aee-1dce-376f-91fe-32647bc613b2 imgt:mAb_1140|imgt:inn_number|11595 imgt:IgG1-kappa_653|rdfs:comment|IgG1 - kappa imgt:Product_964f3a74-fab3-3a7d-b372-0346f67780f4|imgt:isProductOf|imgt:mAb_1251 imgt:isDomainInChain|rdf:type|owl:ObjectProperty imgt:OPI_(Orphan_Pharma_International)|rdfs:label|OPI (Orphan Pharma International) imgt:StudyProduct_0485cef8-ac82-346b-aa36-ae9f4bdb7da9|imgt:development_technology| Triomab® (Trifunctional Ab) imgt:Product_d946876c-2d5b-39e7-947d-0c1325d80a31|imgt:hasStudyProduct|imgt:StudyProduct_fc5cc4ff-cd79-3360-ba2c-9cb8a2518a23 imgt:mAb_677|imgt:hasProduct|imgt:Product_e486c14a-a89f-327e-8f36-b95267609593 imgt:LAG3|imgt:isTargetOf|imgt:IgG4-kappa_1017 imgt:mAb_380|imgt:hasImgtStructureEntry|imgt:6NOV imgt:Clone_344|obo:RO_0002162|imgt:Musmus imgt:R|rdf:type|imgt:ConfigurationType imgt:3GIZ|rdf:type|obo:NCIT_C25402 imgt:StudyProduct_4a15ef37-c104-3c66-be53-61f0924d6fb2|imgt:isStudyProductOf|imgt:Product_31c76a78-4c41-3e46-80fd-2ed38c0b8459 imgt:IgG1-kappa_1107|imgt:hasConstruct|imgt:Construct_1107 imgt:BerGenBio_AS|rdfs:label|BerGenBio AS imgt:IgG2-kappa_929|imgt:isMabReceptorOf|imgt:mAb_929 imgt:Segment_690_1|imgt:hasImgtLabel|imgt:scFv-nd-nd imgt:StudyProduct_8e5e584f-e616-3b66-8159-45ca4319af19|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_34a1caac-6f2c-3e1e-9946-120ac114ef28|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:mAb_587|rdfs:label|mAb_587 imgt:mAb_678|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=678 imgt:Construct_300|rdf:type|imgt:Construct imgt:mAb_245|imgt:inn_name|baminercept imgt:CD19|imgt:isTargetOf|imgt:VH-VL-VH%27-VL%27-CH2-CH3_640 obo:NCIT_C2621|rdfs:subClassOf|obo:NCIT_C1909 imgt:mAb_246|imgt:hasImgtStructureEntry|imgt:8963 imgt:StudyProduct_75b64290-c421-3e24-9fe3-0af1b456877d|rdfs:label|StudyProduct_75b64290-c421-3e24-9fe3-0af1b456877d imgt:Product_9513f6a4-618a-3644-ad7a-e9451f9f3e57|imgt:isProducedBy|imgt:AbbVie_Inc imgt:StudyProduct_10fe858f-824f-3374-b210-1fe3fe64531d|imgt:application_type|Therapeutic imgt:StudyProduct_4a06f6fe-30b7-31d7-ad13-2540acbf81b7|imgt:isStudyProductOf|imgt:Product_166b2758-4ccb-3e25-b5d9-61631837270f imgt:Product_44f47fcb-04de-39c1-99a4-99e993c867a7|imgt:hasStudyProduct|imgt:StudyProduct_a3cc3c99-76ff-3041-8a15-26c76e38ca13 imgt:StudyProduct_c577e61c-dd0a-3058-bf6a-7a818cd5084b|imgt:hasClinicalIndication|imgt:AIDS-related_Kaposi's_sarcoma _:Bee95eff4bc9ae9efa2223b9e7873c257|imgt:hasStatut|imgt:approval imgt:StudyProduct_68144c19-458d-3c01-9bee-0b7e962fcf44|imgt:hasClinicalIndication|imgt:Rabies_post-exposure imgt:Pain_chronic|rdfs:label|Pain_chronic imgt:Huntington’s_disease|rdf:type|obo:NCIT_C185637 imgt:Fc-Gamma-1|imgt:isDefinedBy|imgt:IG-Heavy-Gamma-1-IGHG1 imgt:IgG1-kappa_403|obo:RO_0002162|imgt:Homsap imgt:MAbReceptor_880|obo:RO_0002162|imgt:Homsap imgt:Product_e31dbc73-3522-3fab-9dad-747553a7a7ab|rdfs:label|Product_e31dbc73-3522-3fab-9dad-747553a7a7ab imgt:StudyProduct_f254860d-8ce1-3727-ae18-0a29572ecbcb|rdfs:label|StudyProduct_f254860d-8ce1-3727-ae18-0a29572ecbcb imgt:J-RS|rdfs:label|J-RS imgt:F(ab’)2-Gamma-2-a_Lambda|imgt:isDescribedBy|imgt:F(AB')2-GAMMA-2-A_LAMBDA imgt:Product_25709140-bbc7-373c-9a44-2be9be3d8e9d|imgt:isProductOf|imgt:mAb_1101 imgt:Crucell|imgt:produces|imgt:Product_d9633900-9198-3a1b-92df-7202048ab718 imgt:Product_f18429fd-accd-38a6-8cab-3bba1e74faf4|imgt:comercial_name|CYTOPOINT™ imgt:StudyProduct_dab25960-187a-3ef7-8541-9922a9f0c26b|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:StudyProduct_703128ab-3463-3c40-96ff-e6dbd525fd89|imgt:hasClinicalPhase|imgt:Phase_II imgt:IgG4-kappa-4lys-drug_389|rdf:type|imgt:MAbReceptor imgt:Construct_721|imgt:isConstructOf|imgt:IgG1-kappa-4cys-drug_721 imgt:Chronic_lymphocytic_leukemia_(CLL)|imgt:isClinicalIndicationOf|imgt:StudyProduct_dc38fe22-e028-31bc-9ca5-e6847212466f imgt:StudyProduct_baf5a3f8-f2b2-3580-87de-eebe6eaa9f60|imgt:isStudyProductOf|imgt:Product_7ebb6d25-c5d0-3d40-bc0d-6012f24de5cb imgt:mAb_975|imgt:hasMabReceptor|imgt:IgG2-kappa_975 imgt:mAb_1226|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=1226 imgt:StudyProduct_9cbb6ed7-4cf4-39de-aa16-1e2c03e3191f|rdfs:label|StudyProduct_9cbb6ed7-4cf4-39de-aa16-1e2c03e3191f imgt:IgG1-kappa_714|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:StudyProduct_69ef2360-5f7b-3ffe-915d-120181a43118|imgt:development_technology| No N-glycosylation sites CH2 N84.4A Antibody phage display library imgt:Clone_1009|rdf:type|obo:NCIT_C37925 imgt:StudyProduct_5d73388e-1ce1-3b49-baa5-c24c65fbfd2d|imgt:isStudyProductOf|imgt:Product_b2047389-8f1a-3406-9333-efe3ec11daac imgt:IgG1-lambda-kappa_1281|rdfs:comment|IgG1-lambda-kappa imgt:IgG2-kappa_302|rdfs:comment|IgG2 - kappa imgt:Sichuan_Clover_Biopharmaceuticals_Inc|rdfs:comment|null , China imgt:mAb_113|imgt:inn_proposed_list|74 (1995) imgt:Construct_698|obo:BFO_0000051|imgt:Segment_698_2 imgt:CD3E|imgt:isTargetOf|imgt:IgG2-nd_100 imgt:StudyProduct_a97a8d93-fa7e-3f39-ba19-1929fe3fab4c|imgt:isStudyProductOf|imgt:Product_6fc221fc-63c6-300f-8844-5210f60014c6 imgt:Product_5c98d66d-fb8c-3e2a-b2cf-162c528ac706|imgt:hasStudyProduct|imgt:StudyProduct_54fafb51-6774-36d0-995a-b42da3cb9585 _:Bdf20351a39c5371c4c1288ec01d8294e|rdf:type|obo:NCIT_C53285 imgt:Product_b4003381-5038-3c65-ba73-4fee726f10d5|imgt:commun_name|JNJ-42160443 imgt:mAb_534|imgt:inn_proposed_list|112 (2014) imgt:StudyProduct_e18346b4-c502-3a24-9514-3f9ecb2d5d74|imgt:isStudyProductOf|imgt:Product_704a95ca-527f-35a5-9876-3e1298544145 imgt:IgG1-kappa_905|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:IL1RL1|skos:definition|IL1RL1 (interleukin 1 receptor like 1, DER4, FIT-1, growth stimulation expressed, IL33R) imgt:Fab-G1-kappa_1169|imgt:hasMolecularComponent|imgt:IG imgt:MAbReceptor_110|rdfs:label|MAbReceptor_110 imgt:Segment_421_1|rdf:type|imgt:Segment imgt:StudyProduct_d790e869-4e7c-36d6-bac0-07c0818036ec|imgt:hasDecision|_:B656b3b44342c8c657db92f14a2f2070b imgt:VH-Vkappa-h-CH3_1246|obo:RO_0002162|imgt:Hum imgt:Product_17f1c06a-7254-3bcb-a6b8-f928b4298284|imgt:isProductOf|imgt:mAb_317 imgt:StudyProduct_aafd0d68-6869-32fd-9b11-aa5205ba5962|imgt:application_type|Therapeutic imgt:mAb_698|rdfs:label|mAb_698 imgt:Clone_99|rdfs:label|Clone_99 _:B59c459f416c1887d5ab3c33a80fc2a98|imgt:hasStatut|imgt:approval imgt:IgG4-nd_279|imgt:hasConstruct|imgt:Construct_279 imgt:IgG1-lambda-PROTEIN_1296|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-lambda-PROTEIN.png _:B740865473acdfef0cd54ef1598485944|dc:date|2016-12-22 imgt:IL1R1|rdf:type|imgt:ChainLabels imgt:mAb_1239|imgt:inn_name|betifisolimab imgt:StudyProduct_9f3be9a2-1b53-3811-ab9c-570dba5a823e|rdf:type|obo:NCIT_C174271 imgt:Clone_239|obo:RO_0002162|imgt:Musmus _:B62891c00844c1e7f5d1c2509ccf7b848|imgt:isDecisionOf|imgt:StudyProduct_7b8151d8-918e-34ec-8cf0-edac2cf91f88 imgt:IgG1-kappa_425|imgt:isMabReceptorOf|imgt:mAb_425 imgt:10410|rdfs:label|10410 imgt:Product_1c7d468c-7793-33f3-a5bd-6747d51e1199|rdfs:label|Product_1c7d468c-7793-33f3-a5bd-6747d51e1199 imgt:11347|rdfs:label|11347 imgt:Construct_187|rdfs:label|Construct_187 imgt:Adnexus|imgt:produces|imgt:Product_5dde1122-ca49-3ad6-8e30-d28049e1461d imgt:mAb_155|imgt:imgt_note| WHO Drug Information, Vol. 34, No. 3, 2020. Proposed INN List 124 – COVID-19 (special edition) (9 October 2020) pages 642-669. Proposed INN List 124 (19 December 2020, published on 22 January 2021) pages 929-1102. imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_f765eebb-5180-3806-84f0-27613a9fb127 imgt:FPIA_%5BPROTEIN_4REPEATS%5D2-FC_245|http://semanticscience.org/resource/SIO_000291|imgt:LTA imgt:Hodgkin's_disease_(HD)|rdf:type|obo:NCIT_C185637 imgt:Clone_1190|imgt:isOriginCloneOf|imgt:mAb_1190 imgt:StudyProduct_cfcda5a8-e616-332c-8806-1416043fa534|imgt:isStudyProductOf|imgt:Product_6b42a0d3-1383-3dc2-a533-4f51868e60f6 imgt:pro-MSTN|obo:RO_0002162|imgt:Homsap imgt:mAb_431|rdf:type|obo:NCIT_C152916 imgt:StudyProduct_b54c07e4-3115-3aba-903b-306ce102992a|rdfs:label|StudyProduct_b54c07e4-3115-3aba-903b-306ce102992a imgt:10172|imgt:isImgtStructureEntryOf|imgt:mAb_573 imgt:Construct_746|imgt:isConstructOf|imgt:ELP-PEPTIDE_746 imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_02ea65e9-4c4d-37f8-997d-8e64aeddc41b imgt:IgG1-kappa_411|imgt:hasConstruct|imgt:Construct_411 imgt:Clone_1198|rdf:type|obo:NCIT_C37925 imgt:Crohn's_disease_(CD)|imgt:isClinicalIndicationOf|imgt:StudyProduct_b0a9c41e-d975-3b0d-984c-22ec45ac4969 _:B4cbdc2ccc46682942a66bb86df38810a|imgt:hasDesignation|imgt:Orphan_drug imgt:Segment_1107_1|rdf:type|imgt:Segment imgt:StudyProduct_08ede5e9-5468-3e28-ab2c-a7204ea416e6|imgt:isStudyProductOf|imgt:Product_18e218fa-ac0d-39a4-9e01-9513fbb2bc7c imgt:FAB-GAMMA-2A_V-KAPPA-C-LAMBDA|rdf:type|imgt:IGProteolyticFragmentLabel imgt:Clone_1255|rdfs:label|Clone_1255 imgt:Product_49c2056b-e4db-3d7e-aeaa-1e329f6571e9|imgt:commun_name|VEGF-TRAPR1R2 imgt:Construct_612|obo:BFO_0000051|imgt:Segment_612_2 imgt:FAB-ALPHA-2_KAPPA|imgt:describes|imgt:Fab-Alpha-2_Kappa _:B4f59a5c8713a63eeb2695675c4dfd339|imgt:isDecisionOf|imgt:StudyProduct_340cb88e-bb79-3b53-9e2a-cbd43b517c55 imgt:Product_f6c7a871-ae54-30b2-abf8-50b6400072df|imgt:hasStudyProduct|imgt:StudyProduct_9e55beb8-1f40-3fb0-ba8c-64cc8f6d0555 imgt:ENG|skos:definition|ENG (endoglin, ORW, ORW1, Osler-Rendu-Weber syndrome 1, CD105, END, HHT1) imgt:Segment_700_1|imgt:has_rank|1 imgt:mAb_373|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=373 imgt:Segment_215_1|imgt:has_rank|1 imgt:mAb_332|imgt:inn_proposed_list|102 (2009) imgt:Product_ae26fe5d-0957-3750-9fd4-e84dc4303b03|rdf:type|obo:NCIT_C51980 imgt:Pfizer|imgt:produces|imgt:Product_ba224a9b-4a5f-36b6-9467-5dd2fff90eb2 imgt:IgG1-nd_251|imgt:hasMolecularComponent|imgt:IG imgt:mAb_1223|imgt:hasMabReceptor|imgt:IgG1-kappa-%5BPROTEIN%5D2_1223 pubmed:20593411|rdfs:label|PMID_20593411 imgt:Product_b0d0c09a-7196-3fc5-8676-4db70c57ba7c|rdfs:label|Product_b0d0c09a-7196-3fc5-8676-4db70c57ba7c imgt:IgG1-kappa_1090|imgt:hasConstruct|imgt:Construct_1090 imgt:StudyProduct_acc352ce-3e70-3a5c-a0d3-37040ae6a354|imgt:isStudyProductOf|imgt:Product_eabf76ed-a75b-38a7-beee-34c4b6f691bb imgt:StudyProduct_b11cc987-484a-309d-9ef0-99725f55a76b|imgt:isStudyProductOf|imgt:Product_c4c827f8-eb1f-3253-8d37-f5b1a1d56ac7 imgt:mAb_946|imgt:clinical_trials|1 studies found, 1 recruiting imgt:IgG1-kappa_336|rdfs:comment|IgG1 - kappa imgt:Product_5cde7219-6367-3651-8ae8-f6c007a0a286|imgt:hasStudyProduct|imgt:StudyProduct_292db794-322f-322e-8b76-7185b7823008 imgt:Product_09f71bc7-a665-3626-979f-564df68bd3aa|imgt:isProducedBy|imgt:Novo_Nordisk imgt:H-GAMMA-4|rdf:type|imgt:ChainLabels imgt:Product_9b5614c6-8750-39f5-8dfe-86ffd967ed48|imgt:commun_name|RhuFab _:Bfde56adcf60aa6918c46ccf537dd0925|imgt:hasDesignation|imgt:Orphan_drug imgt:Product_cc23c10b-ddcd-3dab-8705-97745fb10a52|imgt:commun_name|IBI302 imgt:IgG2a-kappa_132|rdfs:comment|IgG2a - kappa obo:NCIT_C95791|rdf:type|owl:Class imgt:Product_2f33022b-bbc0-3f59-bc75-86deb8919d2c|imgt:hasStudyProduct|imgt:StudyProduct_3593e4ce-f227-33e4-a62d-662cc6212276 imgt:StudyProduct_a4579212-c26a-3666-8b80-15da493b5d2b|imgt:application_type|Therapeutic imgt:mAb_1127|imgt:hasProduct|imgt:Product_c7810095-aebe-3853-904f-69aab48efb59 imgt:mAb_1058|imgt:hasImgtStructureEntry|imgt:11290 imgt:Construct_442|imgt:isConstructOf|imgt:IgG4-nd_442 imgt:IgG1-kappa-%5BscFv%5D2-lambda_1124|imgt:hasMolecularComponent|imgt:IG imgt:mAb_142|imgt:centerwatch_link|http://www.centerwatch.com/drug-information/fda-approvals/drug-details.aspx?DrugID=834 imgt:Novartis_Pharmaceuticals_Corp|imgt:produces|imgt:Product_1e1593d1-3859-35ad-82df-143254deca18 imgt:IgG1-kappa-4cys-drug_814|http://semanticscience.org/resource/SIO_000291|imgt:AXL imgt:Segment_1162_1|obo:BFO_0000050|imgt:Construct_1162 imgt:Myelodysplastic_syndromes_(MDS)|rdfs:label|Myelodysplastic_syndromes_(MDS) imgt:Product_d028c76c-dbf1-3420-84a9-31338f6da8fd|imgt:isProductOf|imgt:mAb_78 imgt:11545|rdf:type|obo:NCIT_C25402 imgt:Product_ae14f792-c7fc-3b1a-8720-eab3244c9808|rdf:type|obo:NCIT_C51980 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imgt:StudyProduct_d5c67ac7-981f-3c29-bfc0-5cb699da847b|imgt:application_type|Therapeutic imgt:Product_a0dd8b7d-497f-3e1b-9202-688a37f0520c|rdf:type|obo:NCIT_C51980 imgt:IgG4-kappa_548|obo:RO_0002162|imgt:Chi imgt:mAb_948|imgt:inn_recommended_list|83 (2020) imgt:StudyProduct_53931e74-e525-3e5f-a76b-b4b9eef386f2|imgt:application_type|Therapeutic imgt:StudyProduct_9be1aca9-e335-3957-b164-170056af884c|imgt:hasExpressionSystem|imgt:_CHO_DG44_(Chinese_Hamster_Ovary)_cells imgt:StudyProduct_e82fce6f-f9b1-3c8e-ba70-8a8f50d57e6f|imgt:development_technology| Dual-Affinity Re-targenting (DART®) imgt:StudyProduct_1488b958-4851-3c48-8fe8-dc236ea9ed0f|imgt:application_type|Therapeutic imgt:IgG4-kappa_496|rdfs:label|IgG4-kappa_496 imgt:IL21_(Pr29-162)|rdf:type|imgt:DomainLabel imgt:IgG1-kappa-4lys-drug_357|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa-4lys-drug.png imgt:Segment_52_1|rdfs:label|Segment_52_1 imgt:TR-Gamma-5_Delta|imgt:isDefinedBy|imgt:TR-Gamma-5-TRGC5 imgt:StudyProduct_51366621-f546-3023-ab2f-c477c16bd40e|imgt:hasClinicalIndication|imgt:Multiple_myeloma_(MM) imgt:Influenza_A_infection|imgt:isClinicalIndicationOf|imgt:StudyProduct_891fb42a-584d-39d0-adbc-58d869837ab6 imgt:Anaplastic_large_cell_lymphoma_(ALCL)|imgt:isClinicalIndicationOf|imgt:StudyProduct_64df6f56-9ee1-3540-ae4c-8f714b5cdb93 imgt:Product_ba9a3cb6-5aea-31ea-aaac-4066f6413074|imgt:isProductOf|imgt:mAb_190 imgt:StudyProduct_156f8352-f12f-38a5-a6ac-4ec4ba7a2208|imgt:application_type|Therapeutic imgt:StudyProduct_18e0dcd9-8b03-30d1-bb02-5183ea764f91|imgt:isStudyProductOf|imgt:Product_b53d5313-835d-3d6b-8fb3-a4650e3a36ef imgt:Segment_1063_1|rdf:type|imgt:Segment imgt:ADAMTSL5|imgt:isTargetOf|imgt:VH-VH%27_1014 imgt:Construct_213|imgt:isConstructOf|imgt:FPIA_%5BPROTEIN_2REPEATS%5D2-FC_213 _:B1b1f6d8619a28a8b65ef36792f784c6b|imgt:hasStatut|imgt:approval _:B5d1565c721f706031f60b91ca33f52e4|imgt:isDecisionOf|imgt:StudyProduct_2a63fd24-af5c-31ed-9c46-cda848997546 obo:NCIT_C150590|rdf:type|owl:Class imgt:Product_804344aa-9846-368c-b3c2-764390d1bcc8|imgt:hasStudyProduct|imgt:StudyProduct_21a3907b-7b30-3617-a153-ce5d264de8bc imgt:mAb_170|imgt:hasProduct|imgt:Product_ecd571df-a174-39e9-b5a2-5297330de6a7 imgt:skeletal-related_events_in_patients_with_bone_metastases_from_solid_tumors|imgt:isClinicalIndicationOf|imgt:StudyProduct_8fa0a452-5792-33e2-a012-f986e36e6fca imgt:Segment_322_1|imgt:has_rank|1 imgt:IgG1-kappa-%5BPROTEIN%5D2_900|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa-[PROTEIN]2.png imgt:ITGAV|skos:definition|ITGAV (integrin alpha V, CD51) imgt:Product_d435ac5c-4b8d-3683-9fae-ecfcb9abc376|imgt:commun_name|IMGN-529 obo:NCIT_C87768|rdfs:subClassOf|obo:NCIT_C1909 imgt:Segment_1119_1|obo:BFO_0000050|imgt:Construct_1119 imgt:%5BPROTEIN-PROTEIN%5D3_1297|rdfs:label|[PROTEIN-PROTEIN]3_1297 imgt:mAb_931|rdf:type|obo:NCIT_C166732 imgt:9985|imgt:isImgtStructureEntryOf|imgt:mAb_553 imgt:mAb_117|imgt:hasOriginClone|imgt:Clone_117 imgt:IgG4-nd_182|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG4-nd.png _:B2bb2a042101b72227916cb62a0f8da6d|dc:date|2004-09-02 imgt:mAb_259|imgt:inn_recommended_list|54 (2005) imgt:F(ab’)2-Gamma-2-c_Lambda|rdf:type|imgt:ReceptorType imgt:Product_e4d5d466-4b87-329b-8a1c-621db7be6033|imgt:commun_name|PRV-015 imgt:MH-Gene|rdf:type|owl:Class imgt:CH2D3|rdfs:label|CH2D3 imgt:L-PART1|rdf:type|imgt:LeaderLabel imgt:hasMabReceptor|rdfs:range|imgt:MAbReceptor imgt:mAb_279|imgt:inn_name|reslizumab imgt:di-%5BFab%27-G1-kappa-maleimide-PEG%5D_233|imgt:hasMolecularComponent|imgt:IG imgt:Segment_755_1|imgt:has_rank|1 obo:NCIT_C128138|rdf:type|owl:Class imgt:Product_6a1cb947-c2d5-34b2-8eeb-4b8d2758875a|imgt:isProductOf|imgt:mAb_600 imgt:Shanghai_Henlius_Biotech|rdfs:comment|Shanghai , China imgt:StudyProduct_82596810-73a4-3823-92ab-f261c6581d9e|rdf:type|obo:NCIT_C174271 imgt:IgG1-lambda_290|rdf:type|imgt:MAbReceptor _:B5945554228cbc765b607198217bca299|rdf:type|obo:NCIT_C53285 imgt:IgG1-lambda_189|obo:RO_0002162|imgt:Homsap imgt:FPIA_%5BPROTEIN_VLIKE%5D2-1S-FC_247|imgt:hasConstruct|imgt:Construct_247 imgt:StudyProduct_73ab36bd-5102-3aa2-b945-5975cdc7247f|imgt:hasClinicalPhase|imgt:Phase_I imgt:mAb_202|rdfs:label|mAb_202 imgt:Shanghai_Junshi_Biosciences_Co_Ltd|imgt:produces|imgt:Product_b46cfd0f-f1cb-3275-b6c3-ba2bf56710be imgt:mAb_465|imgt:inn_recommended_list|71 (2014) imgt:Allergic_diseases|imgt:clinical_domain|Immunology imgt:TNFRSF10A|skos:definition|TNFRSF10A (tumor necrosis factor receptor (TNFR) superfamily member 10A, death receptor 4, DR4, TNF-related apoptosis-inducing ligand receptor 1, TRAILR1, TRAIL-R1, TR-1, CD261) imgt:StudyProduct_3e1c3e75-0f62-3155-a4de-382c650b2cc0|imgt:hasClinicalPhase|imgt:Phase_I imgt:Hereditary_Angioedema (HAE)|rdfs:label|Hereditary_Angioedema (HAE) imgt:FAB-GAMMA-2_KAPPA|rdf:type|imgt:IGProteolyticFragmentLabel imgt:IgG1-kappa_1023|rdf:type|imgt:MAbReceptor imgt:Product_56e1aba5-d1fa-3556-89ad-76c1dd577359|imgt:commun_name|4D5-8 and UCHT1 imgt:Construct_784|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:StudyProduct_d13d1a3c-d413-3b7e-b0ac-f0bfc6d23850|imgt:isStudyProductOf|imgt:Product_56576134-cfbd-35a6-b65a-05844543f13f imgt:Segment_1120_1|rdf:type|imgt:Segment imgt:Segment_129_1|imgt:hasImgtLabel|imgt:IgM-kappa imgt:IgA2_Lambda|imgt:isDefinedBy|imgt:IG-Light-Lambda-IGL imgt:Product_d75165ab-4ffe-3b58-a051-77afd4e2bb75|imgt:hasStudyProduct|imgt:StudyProduct_d75165ab-4ffe-3b58-a051-77afd4e2bb75 imgt:Product_64290ba9-0505-3e73-bd11-364751196aba|imgt:commun_name|RhuMAB IFNalpha imgt:Segment_944_1|obo:BFO_0000050|imgt:Construct_944 imgt:Carcinoma_cervical_late-stage_or_metastatic|imgt:isClinicalIndicationOf|imgt:StudyProduct_4b9163ff-aee3-3824-823f-d7e8827fa346 imgt:mAb_876|rdf:type|imgt:INN imgt:Product_4eeaa614-ef03-3234-84a9-d2d1c82a6455|imgt:hasStudyProduct|imgt:StudyProduct_8af1e719-689a-35b9-92a5-6b2498438bae imgt:9688|rdfs:label|9688 imgt:Product_34d390d4-4caa-3b24-b9bd-975fca71bdeb|imgt:commun_name|REGN5458 imgt:StudyProduct_55146c27-621e-353f-a87d-430a39e8e3e8|imgt:hasClinicalIndication|imgt:Cancers_colorectal_(CRC) imgt:D-sequence|protege:protege#subclassesDisjoint|true imgt:mAb_547|imgt:imgt_note| Modified in its Fc region to increase\r the binding to the human inhibitory Fc receptor FCGR2B, which leads to a\r selective B cell inhibition (XmAb immune inhibitory Fc domain\r technology). imgt:mAb_523|imgt:hasProduct|imgt:Product_44a38db4-d2d7-391f-9a70-0d60c3d06106 imgt:Segment_281_1|obo:BFO_0000050|imgt:Construct_281 imgt:10687|rdfs:label|10687 imgt:mAb_740|rdfs:label|mAb_740 imgt:TR-ALPHA_BETA|skos:definition|TR receptor comprising one TR-ALPHA and one TR-BETA chains imgt:mAb_1064|imgt:hasMabReceptor|imgt:IgG2-kappa_1064 imgt:StudyProduct_f0431bbe-f9ca-3eba-a26f-88d04c64aaaf|imgt:hasDecision|_:B1710fb856fbc319d2f26302e5c7f45b2 imgt:StudyProduct_760fad9c-0830-3288-a159-d62895ffea3e|imgt:hasClinicalPhase|imgt:Phase_II imgt:mAb_377|imgt:inn_name|conbercept imgt:IgG1-kappa_647|rdf:type|imgt:MAbReceptor imgt:Segment_566_1|rdfs:label|Segment_566_1 imgt:StudyProduct_8014be85-e506-3e07-ae18-b2a0ef6af59c|imgt:isStudyProductOf|imgt:Product_c49fe1bd-70e4-3192-91d0-1125b060119b imgt:Product_b2895cfe-5c84-354a-bccf-c88c0e46a211|imgt:isProductOf|imgt:mAb_893 imgt:Construct_678|imgt:isConstructOf|imgt:IgG4-kappa_678 imgt:StudyProduct_7176d990-6d3d-3a30-b428-1afcc64e0c0f|imgt:isStudyProductOf|imgt:Product_6b3150d9-5508-39df-a43d-348dac71bd4c imgt:StudyProduct_c705bca7-5973-3e15-87f9-106e3fa87b06|imgt:hasClinicalPhase|imgt:Phase_I imgt:IgG1-kappa_720|imgt:hasConstruct|imgt:Construct_720 imgt:mAb_405|rdf:type|imgt:INN imgt:Segment_701_1|rdf:type|imgt:Segment imgt:StudyProduct_54944a58-885e-3faa-910e-36c9c4a047ee|imgt:isStudyProductOf|imgt:Product_380468a1-298c-37f8-8d02-622fb021aa02 imgt:StudyProduct_9a2b5a71-1177-36a9-b7ba-340e1d5099e9|imgt:hasClinicalIndication|imgt:HIV-1_infection_AIDS imgt:VH-VH%27_1014|http://semanticscience.org/resource/SIO_000291|imgt:bivalent imgt:StudyProduct_0eff14ed-1068-3f6d-bf44-6823ff8f985a|imgt:hasClinicalIndication|imgt:Psoriatic_arthritis_(PSA) imgt:NCBI_Gene_link|dc:identifier|imgt_000317 imgt:StudyProduct_29562df2-37fe-38ae-a623-e694518eba7f|imgt:hasClinicalPhase|imgt:Phase_M imgt:Construct_389|rdfs:label|Construct_389 imgt:StudyProduct_6418f006-4cac-3121-b996-6d1a74606cd0|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cellsNS0_mouse_myeloma_cells imgt:mAb_873|imgt:inn_number|10906 obo:NCIT_C104012|rdfs:subClassOf|obo:NCIT_C1909 imgt:V-LAMBDA|rdf:type|imgt:ChainLabels imgt:StudyProduct_c44aacf9-e7e1-3fa0-b1f9-cadc07c21760|rdf:type|obo:NCIT_C174271 imgt:D-J-C-SEQUENCE|rdfs:label|D-J-C-SEQUENCE imgt:Construct_1158|imgt:hasImgtLabel|imgt:%5BFLT1_(fms-related_tyrosine_kinase_1_vascular_endothelial_growth_factor_receptor_1_VEGFR-1_VEGFR_FLT_FRT_vascular_permeability_factor_receptor)_domain_2_fragment_(132-232)-KDR_(kinase_insert_domain_receptor_vascular_endothelial_growth_factor_receptor_2_VEGFR2_VEGF-R2_FLK1_CD309)_domain_3_fragment_(227-327)-FGFR1_(fibroblast_growth_factor_receptor_1_FLT2_KAL2)_domains_2_and_3_fragment_(150-361)%5D2-IGHG1_Fc_(Fragment_constant) imgt:StudyProduct_1990a1c2-dc0c-3e14-80eb-7a111e2e1cc9|imgt:isStudyProductOf|imgt:Product_1c7d468c-7793-33f3-a5bd-6747d51e1199 imgt:Product_70afe02b-053c-3bb6-a9a0-a670b69fb01d|imgt:commun_name|AMG199 imgt:StudyProduct_628cc4c4-33ab-343b-b095-6c6b7cde48d8|rdfs:label|StudyProduct_628cc4c4-33ab-343b-b095-6c6b7cde48d8 imgt:mAb_761|rdfs:label|mAb_761 imgt:4KAQ|rdfs:label|4KAQ imgt:StudyProduct_39fabc0f-de7a-3eb0-a3aa-bc74ad2aa805|imgt:hasClinicalIndication|imgt:Interstitial_cystitis imgt:Construct_180|obo:BFO_0000051|imgt:Segment_180_1 imgt:Construct_664|rdfs:label|Construct_664 imgt:Segment_497_1|rdfs:label|Segment_497_1 imgt:Product_60d50ddc-7055-3124-936b-1628e2af1236|imgt:comercial_name|AVASTIN® imgt:Segment_960_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Eosinophilic_gastritis|rdfs:label|Eosinophilic_gastritis imgt:mAb_571|rdfs:label|mAb_571 imgt:IgG1-kappa-6cys-drug_559|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa-6cys-drug.png imgt:IgG1-kappa-%5BPROTEIN%5D2_IFNA2_1157|rdf:type|imgt:MAbReceptor imgt:StudyProduct_80c6a98c-789d-318d-981c-2c7e58181910|imgt:hasClinicalIndication|imgt:Cancers_gastric _:B24d3367f88f690f3d3cc1b45bb2ab5db|imgt:isDecidedBy|imgt:FDA imgt:StudyProduct_43efb9a3-51a2-3c78-9f5a-0ad2da495853|rdfs:label|StudyProduct_43efb9a3-51a2-3c78-9f5a-0ad2da495853 imgt:mAb_1272|rdf:type|obo:NCIT_C1909 imgt:Construct_1054|imgt:hasImgtLabel|imgt:scFv-h-CH2-CH3(_scFv)_h-CH2-CH3_ imgt:MAbReceptor_346|http://semanticscience.org/resource/SIO_000291|imgt:HAVCR1 imgt:StudyProduct_93876f3d-de44-338d-8cf8-62103fc576df|rdf:type|obo:NCIT_C174271 imgt:mAb_906|rdf:type|imgt:INN imgt:Product_a1bd042a-5618-349f-b413-1f465cdadc23|imgt:commun_name|STRO 002 imgt:StudyProduct_e10fb030-a327-3e32-9249-263591627ebd|imgt:hasDecision|_:B94dd5d9cbe6add4da11806501e4367c3 imgt:Clone_200|imgt:isOriginCloneOf|imgt:mAb_200 imgt:Alternative_to_antigen_receptors_(domain_scaffold:_TNC-F3_tenascin_domain_F3)_2_TNC-F3_domains|rdfs:label|Alternative to antigen receptors (domain scaffold: TNC-F3, tenascin domain F3) 2 TNC-F3 domains imgt:Cancer_gynecology|imgt:isClinicalIndicationOf|imgt:StudyProduct_7f323b91-0d3f-3fa8-903c-b3a2efe0d98d imgt:scFv-scFv-scFc_lambda_1200|imgt:isMabReceptorOf|imgt:mAb_1200 imgt:mAb_1107|rdfs:label|mAb_1107 imgt:mAb_1178|imgt:hasMabReceptor|imgt:IgG1-kappa_1178 imgt:StudyProduct_5366ddef-ab99-306b-8386-88bf093ea87c|imgt:application_type|Therapeutic imgt:Product_1c53045c-f69d-32cc-92d5-edd603543aa2|imgt:hasStudyProduct|imgt:StudyProduct_0a9ebf98-2862-3f47-984d-b0a63bc0d12f imgt:Construct_895|rdf:type|imgt:Construct imgt:Construct_894|imgt:hasImgtLabel|imgt:IgG4-lambda imgt:Segment_733_1|imgt:hasImgtLabel|imgt:TNFRSF1B imgt:Product_8f490102-cdea-34aa-b788-031461c9e8b8|imgt:hasStudyProduct|imgt:StudyProduct_3cf885c8-c7b2-3a9b-b637-6fadb2324fb9 obo:NCIT_C152246|rdf:type|owl:Class imgt:IgG1-kappa_240|imgt:isMabReceptorOf|imgt:mAb_240 obo:NCIT_C124133|rdf:type|owl:Class imgt:Clone_90|obo:RO_0002162|imgt:Homsap imgt:Product_e9e52bcc-24ec-39dc-8de4-b4ba591c6845|imgt:commun_name|AMG827 imgt:Segment_1233_1|rdf:type|imgt:Segment imgt:StudyProduct_27b295f8-143b-37a3-a8ca-e4f960e36112|imgt:application_type|Therapeutic imgt:Construct_473|rdfs:label|Construct_473 imgt:Clone_1132|rdfs:label|Clone_1132 imgt:StudyProduct_b3d2cd03-b596-35e4-8143-3721e37d4d28|imgt:hasClinicalPhase|imgt:Phase_M imgt:StudyProduct_5b4c30e9-b6a0-3e4a-9b78-588936d32aba|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_0861d476-232d-3873-9015-7a3cb3d4393c|imgt:hasClinicalIndication|imgt:Steroid-refractory_acute_GvHD_(SR-GvHD) imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_cefa8368-6b8a-3192-a989-b639d2336e2e imgt:StudyProduct_c75294a2-ea9c-39c5-945a-77fcbfc9098c|imgt:hasClinicalIndication|imgt:Rheumatoid_arthritis_(RA) imgt:MAbReceptor_31|rdfs:label|MAbReceptor_31 imgt:TR-Gamma-1_Delta|imgt:isDefinedBy|imgt:TR-Gamma-1-TRGC1 imgt:StudyProduct_b31c56e7-f9c2-3ba1-84cb-423c076d96f1|imgt:isStudyProductOf|imgt:Product_8a67a6f9-7bd2-3e9c-9f93-62b19d17ce77 imgt:4KAQ|rdf:type|obo:NCIT_C25402 imgt:StudyProduct_ba74e17d-054e-3ed5-8dbc-8dbe4ef00021|imgt:hasClinicalIndication|imgt:Solid_tumors imgt:Product_5024ee29-d1ef-33f4-9ff5-34e4c3a98933|imgt:hasStudyProduct|imgt:StudyProduct_6f051fa3-85d4-36c5-8882-7d93ca861a8f imgt:StudyProduct_20e8e725-943b-3b5e-8b74-61b52cd48797|imgt:hasClinicalPhase|imgt:Phase_I imgt:Mesothelioma_malignant|imgt:clinical_domain|Oncology imgt:mAb_774|rdfs:label|mAb_774 imgt:StudyProduct_50882e8c-9e93-3396-af61-b85d9288be59|imgt:hasClinicalIndication|imgt:Cancers_gastric imgt:PROTEIN_1DOMAIN-PEG_636|rdfs:label|PROTEIN_1DOMAIN-PEG_636 imgt:Rhein-Minapharm|imgt:produces|imgt:Product_09c01ca5-976f-3de9-81cb-3dc784cbc65f imgt:mAb_935|rdf:type|imgt:INN imgt:4KRO|imgt:isImgtStructureEntryOf|imgt:mAb_151 imgt:StudyProduct_b35fef56-9616-3739-b99e-e60d25ac99ff|rdfs:label|StudyProduct_b35fef56-9616-3739-b99e-e60d25ac99ff obo:NCIT_C90562|rdfs:subClassOf|obo:NCIT_C1909 imgt:StudyProduct_e2e85e71-8474-3ca4-819d-c7d2a030d59b|rdfs:label|StudyProduct_e2e85e71-8474-3ca4-819d-c7d2a030d59b imgt:mAb_407|rdf:type|imgt:INN imgt:Product_bd699630-ef8f-32d5-a803-0638e592679a|imgt:commun_name|BAY1129980 imgt:MAPT|imgt:isTargetOf|imgt:IgG4-kappa_579 imgt:mAb_196|imgt:imgt_note| Biopharmaceuticals in the U.S. and European Markets New entries in the 4th edition. Origine clone from XenoMouse (Abgenix/ Fremont CA USA) Abgenix was acquired by Amgen in 2006. panitumumab molecular formula is the one amended in L96 (2006) and published in R57 (2007). imgt:Segment_747_1|imgt:has_rank|1 imgt:Construct_734|obo:BFO_0000051|imgt:Segment_734_1 imgt:StudyProduct_6f8cddae-e152-3d3a-b567-2a79a7822890|imgt:application_type|Therapeutic imgt:mAb_1198|rdf:type|obo:NCIT_C184866 imgt:Bos_taurus_FSH_(follicle-stimulating_hormone)-CTP_(C-terminal_peptide_of_the_β-subunit_of_human_chorionic_gonadotropin_(hCG))|rdf:type|imgt:ConstructLabels imgt:IgG2-kappa_975|imgt:hasMolecularComponent|imgt:IG imgt:Corvas_International_Inc|rdfs:label|Corvas International Inc. imgt:mAb_84|imgt:hasBiosimilar|imgt:byooviz™ imgt:IgG1-kappa_867|imgt:hasConstruct|imgt:Construct_867 imgt:Product_b00bbc72-a2a5-3954-855d-e474999d9c18|imgt:hasStudyProduct|imgt:StudyProduct_ffac5a55-cde1-3888-87c9-8b7a7cbed014 imgt:FCER2|obo:RO_0002162|imgt:Homsap imgt:Construct_1242|imgt:isConstructOf|imgt:IgG1-kappa_1242 imgt:Construct_82|obo:BFO_0000051|imgt:Segment_82_1 imgt:StudyProduct_411edc1f-fc5e-3f7d-a48b-d2018846effe|imgt:hasClinicalIndication|imgt:Colitis_ulcerative_(UC) _:B5767f3b75b7c948c6447753200dba09f|dc:date|2013-06-05 imgt:mAb_16|rdfs:label|mAb_16 imgt:Product_dfacdb0c-b486-3d1e-aa2b-38d3b8a8a4ee|imgt:hasStudyProduct|imgt:StudyProduct_fd6de48f-4814-343e-a035-1badad487766 imgt:L-V-D-J-C-sequence|skos:definition|Identifies, for cDNA, molecule entities with a leader L region, a rearranged V region, at least one rearranged D region, a rearranged J region and a C region in undefined configuration. L-V-D-J-C-sequence is in rearranged configuration. imgt:IgA_Kappa|imgt:isDefinedBy|imgt:IG-Light-Kappa-IGKC imgt:Product_4391f6b4-98b1-38e2-94d2-967326f820fe|imgt:hasStudyProduct|imgt:StudyProduct_bfb2e54a-e89b-3b48-b84d-cdbd91007b2d imgt:FG-LOOP|skos:definition|third loop according to the IMGT unique numbering (codon positions 105 to 117 in V-LIKE-DOMAIN), in gDNA or in cDNA imgt:Construct_321|rdfs:label|Construct_321 imgt:IgG1-nd-%5BPROTEIN%5D2_254|imgt:fused_with| IL2 (interleukin 2, IL-2) imgt:mAb_948|rdfs:label|mAb_948 imgt:mAb_1116|imgt:hasProduct|imgt:Product_43b270ab-cd45-3fb5-8ca6-df0952c4ef21 imgt:Product_d028c76c-dbf1-3420-84a9-31338f6da8fd|imgt:hasStudyProduct|imgt:StudyProduct_e042ff46-4b1e-3ada-a670-51cfc81ecaba imgt:mAb_386|imgt:inn_recommended_list|67 (2012) obo:NCIT_C156705|rdf:type|owl:Class imgt:StudyProduct_24c7d0f6-354b-3443-a377-8958069cb8dd|imgt:hasClinicalIndication|imgt:Atopic_dermatitis_(AD) imgt:StudyProduct_9e3781cc-21f2-3583-b63d-a970342c3ed1|imgt:application_type|Therapeutic imgt:Product_d829c3cd-3223-3480-91af-ae2450ad4b2d|rdfs:label|Product_d829c3cd-3223-3480-91af-ae2450ad4b2d imgt:Construct_827|rdf:type|imgt:Construct imgt:StudyProduct_df79e528-b623-3bdd-8719-f6dfbc30099a|rdfs:label|StudyProduct_df79e528-b623-3bdd-8719-f6dfbc30099a imgt:mAb_653|imgt:inn_name|telisotuzumab vedotin imgt:StudyProduct_3938e3bf-5caa-3bde-a890-4e5001b4a0ae|rdfs:label|StudyProduct_3938e3bf-5caa-3bde-a890-4e5001b4a0ae imgt:IgG1-kappa_79|imgt:isMabReceptorOf|imgt:mAb_79 imgt:IgG1-lambda_468|rdf:type|imgt:MAbReceptor imgt:mAb_478|rdf:type|obo:NCIT_C116747 obo:NCIT_C157242|rdf:type|owl:Class imgt:StudyProduct_8ed4d910-b699-3ce4-8c84-724b05ea462a|imgt:hasDecision|_:B90064bd5c7850a9d5249918ae7b19d48 imgt:mAb_156|imgt:centerwatch_link|http://www.centerwatch.com/drug-information/fda-approvals/drug-details.aspx?DrugID=703 imgt:mAb_1157|imgt:inn_name|eramkafusp alfa imgt:Cancers_colorectal_(CRC)|imgt:isClinicalIndicationOf|imgt:StudyProduct_5add4e94-baa2-309c-b366-ccec806a3556 imgt:_Sp2/0-Ag14_mouse_hybridoma_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_6159ba4f-4996-34de-843a-75de55eb9a82 imgt:Segment_1115_1|obo:BFO_0000050|imgt:Construct_1115 imgt:truxima®|imgt:isBiosimilarOf|imgt:mAb_161 imgt:StudyProduct_24f7a218-01dc-3469-b000-c47934d7f395|imgt:development_technology| MorphoSys's HuCAL® phage library imgt:mAb_449|imgt:inn_name|dupilumab imgt:StudyProduct_f8e070f0-9178-373d-9d81-ffb46c539e03|rdfs:label|StudyProduct_f8e070f0-9178-373d-9d81-ffb46c539e03 imgt:mAb_446|imgt:inn_proposed_list|108 (2012) imgt:StudyProduct_c89cbb23-8426-3d1a-923b-6d4614067671|imgt:hasDecision|_:B0566436fbd4e51723f3cdc29c9086e7a imgt:IgG1-kappa-S239C_2cys-drug_552|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa-S239C_2cys-drug.png imgt:IgG1-kappa_MM_5|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa_MM.png imgt:StudyProduct_04732c56-2fa2-382b-bddc-28429ab285c5|imgt:isStudyProductOf|imgt:Product_04732c56-2fa2-382b-bddc-28429ab285c5 imgt:Product_e457f880-631c-3188-aa6a-c8ab128920c4|imgt:isProductOf|imgt:mAb_73 obo:NCIT_C175858|rdfs:subClassOf|obo:NCIT_C1909 imgt:Construct_259|imgt:hasImgtLabel|imgt:IgG4-kappa imgt:Construct_1182|imgt:isConstructOf|imgt:G1_L-kappa_VH-VH-h-CH2-CH3_1182 imgt:mAb_457|rdfs:label|mAb_457 imgt:Segment_553_1|rdf:type|imgt:Segment imgt:Product_e29ca1a6-d717-32be-8922-7f11c322da77|imgt:commun_name|CR6261 imgt:Product_51d4c376-f2c0-341a-bd4d-be7c150e0bcf|rdfs:label|Product_51d4c376-f2c0-341a-bd4d-be7c150e0bcf imgt:PROTEIN_1DOMAIN-PEG_634|imgt:isMabReceptorOf|imgt:mAb_634 imgt:Product_e6cefd95-eb16-32aa-adc9-813b1166be33|imgt:comercial_name|SARCLISA® pubmed:7636241|dc:contributor|Zhu Z imgt:Construct_1221|rdf:type|imgt:Construct obo:NCIT_C170329|rdfs:subClassOf|obo:NCIT_C1909 pubmed:16139892|rdf:type|bibo:Article pubmed:2513570|dc:contributor|Selick H.E. imgt:Clone_951|imgt:clone_name|B100.03 imgt:Allele|owl:disjointWith|imgt:Clan imgt:mAb_583|imgt:imgt_note| ALX-0171 is an anti-RSV therapeutic administered via inhalation, developed for delivery directly into the lungs by nebulization (i.e. the site of RSV infection) imgt:PROTEIN_1DOMAIN_983|http://semanticscience.org/resource/SIO_000291|imgt:IL15RA imgt:mAb_490|imgt:inn_recommended_list|71 (2014) imgt:mAb_1150|imgt:hasMabReceptor|imgt:IgG1-kappa_1150 imgt:StudyProduct_fb834bc6-a761-32b7-ac2b-49f6c3d77751|imgt:hasClinicalIndication|imgt:Ebola_virus_infection imgt:Segment_289_1|rdfs:label|Segment_289_1 imgt:StudyProduct_e8de6321-19d6-3051-8bd9-c4b71bd85892|rdfs:label|StudyProduct_e8de6321-19d6-3051-8bd9-c4b71bd85892 imgt:StudyProduct_e95d8172-69b4-3985-b651-5cb4d80572eb|imgt:hasClinicalIndication|imgt:Autoimmune_diseases imgt:Segment_408_2|imgt:hasImgtLabel|imgt:peptide_14-mer pubmed:18088084|dc:contributor|Zhang J _:Bce25bc9a87435ede4610d7dab9305954|imgt:isDecisionOf|imgt:StudyProduct_f7561f72-0990-36e2-8c23-3a140fc30e6f imgt:Construct_908|rdf:type|imgt:Construct imgt:KaloBios_Pharmaceuticals_Inc|imgt:produces|imgt:Product_93b5b63f-481c-3979-a231-2203ce84fd3d imgt:Clone_111|rdfs:label|Clone_111 imgt:mAb_1091|imgt:inn_proposed_list|123 (2020) imgt:Construct_448|imgt:hasImgtLabel|imgt:IgG2-lambda imgt:StudyProduct_d38adcb9-be8c-3c76-a9a7-382cf9420404|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_2504433f-6dc2-3591-a1a6-a2208e6da256|imgt:isStudyProductOf|imgt:Product_01c8c08f-9ca7-36b5-8234-6c0cbbe33511 imgt:Product_a67505b3-33ab-373f-8cc4-0f19a5a0e8ab|imgt:commun_name|RG-7116 imgt:ENZ-XTEN_702|imgt:fused_with| XTEN (protein polymer) imgt:mAb_503|imgt:inn_name|begelomab imgt:StudyProduct_22910d83-95f1-3be1-b7a4-71438d1b12d4|rdfs:label|StudyProduct_22910d83-95f1-3be1-b7a4-71438d1b12d4 imgt:Clone_78|imgt:isOriginCloneOf|imgt:mAb_78 imgt:PROTEIN_2DOMAINS_2F_278|http://semanticscience.org/resource/SIO_000291|imgt:IFNB1 imgt:Product_75f84b83-eb14-3a03-a9e0-3efba822c52f|imgt:hasStudyProduct|imgt:StudyProduct_4585a5fe-30e1-3f1a-b4e6-d891c9afd909 imgt:StudyProduct_91f98a6d-df36-348b-a99f-fd5e970a4186|rdfs:label|StudyProduct_91f98a6d-df36-348b-a99f-fd5e970a4186 imgt:Product_71907de7-5031-39df-916b-6180a1642a1c|imgt:hasStudyProduct|imgt:StudyProduct_b9c1c916-5714-3827-9cc3-e400f7b2e42c imgt:Segment_885_1|imgt:has_rank|1 imgt:mAb_1151|rdf:type|obo:NCIT_C179131 imgt:Product_ee63dd0e-c659-3edb-b9e8-728ccca5e064|imgt:commun_name|Fab C225 pubmed:10083541|dc:contributor|Hall ML imgt:ALPL|rdfs:label|ALPL imgt:Product_82d6fc7f-1e50-3627-b139-c7c5ec05c31b|rdfs:label|Product_82d6fc7f-1e50-3627-b139-c7c5ec05c31b imgt:Construct_352|imgt:isConstructOf|imgt:IgG1-kappa_352 imgt:Product_e6f04a0c-4b5c-325b-b456-b2dcb5989925|imgt:isProducedBy|imgt:Versatis_Inc obo:NCIT_C156172|rdf:type|owl:Class _:B627339d69f52151d0f77a63d85ca875e|dc:date|2005-08-12 imgt:StudyProduct_f27f0576-2955-3f34-b8f5-1c8f6feec033|imgt:application_type|Therapeutic imgt:Morphotek_Inc|imgt:produces|imgt:Product_66c1ccb4-fede-3350-b3b2-b3f8a1777ea0 imgt:FC-EPSILON|rdfs:label|FC-EPSILON imgt:StudyProduct_05d9da1b-2484-32a8-bb56-e744eba499d6|imgt:hasDecision|_:B7327bae52f39fe324aa633a1c809a639 imgt:Product_fe7efa7c-2cf6-3541-aef7-aa0c8a6163e7|rdf:type|obo:NCIT_C51980 imgt:mAb_1134|rdf:type|imgt:INN imgt:Product_9dfcd5e5-58df-304a-af37-f137a1d9d3e5|imgt:hasStudyProduct|imgt:StudyProduct_9dfcd5e5-58df-304a-af37-f137a1d9d3e5 imgt:Product_ac4234a5-6b5e-3bf3-94f4-def2b50f16fd|imgt:commun_name|Technetium (99mTc) sulesomab, LeukoScan imgt:StudyProduct_0ebea443-410a-3389-80d3-a2436982b339|imgt:hasClinicalPhase|imgt:Phase_II imgt:StudyProduct_dece01d9-67ae-3cd7-8c6c-b0a053d1f3e8|imgt:development_technology| Medarex's HuMAb-Mouse® Transgenic mouse imgt:mAb_93|rdfs:label|mAb_93 imgt:mAb_192|imgt:inn_proposed_list|94 (2005) imgt:Construct_359|imgt:isConstructOf|imgt:IgG1-kappa_359 imgt:Construct_353|rdfs:label|Construct_353 imgt:CH2-CH3|imgt:describes|imgt:IG-Heavy-Gamma-2-c-IGHG2C imgt:Solid_tumors|imgt:isClinicalIndicationOf|imgt:StudyProduct_54a14ca8-f916-338b-af18-d079beb598a4 imgt:StudyProduct_82dde1e2-eead-3694-b95a-d3c6a1467300|imgt:hasClinicalIndication|imgt:Cancers_colorectal_(CRC) imgt:mAb_224|imgt:inn_number|9029 imgt:Product_ef575e88-37d0-35a1-a83c-022d2077d342|rdf:type|obo:NCIT_C51980 imgt:mAb_797|imgt:inn_name|onfekafusp alfa imgt:StudyProduct_6ba65a28-3657-3e97-b336-766e043f01f2|rdf:type|obo:NCIT_C174271 imgt:Product_b986b41d-7c9e-35e9-89a2-8bf0e574d823|rdf:type|obo:NCIT_C51980 imgt:IgG2-kappa_2bridges_527|imgt:hasMolecularComponent|imgt:IG imgt:Product_485d748c-9ee2-352a-aaf4-3297a649c274|imgt:hasStudyProduct|imgt:StudyProduct_b4bb4705-f4d0-3d61-baa4-4e3e5f23b41e _:Bd0251365ce77111d055b63b3119cb29f|imgt:isDecidedBy|imgt:FDA imgt:IgG1-kappa_660|imgt:hasConstruct|imgt:Construct_660 imgt:mAb_19|rdf:type|obo:NCIT_C1909 imgt:StudyProduct_ab579b46-5b62-3349-b790-7a05c13bb56b|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:hexahistidine|rdf:type|imgt:SegmentLabels imgt:Segment_960_1|rdf:type|imgt:Segment imgt:StudyProduct_08a430cc-2e25-3c2f-a8b8-423cb63faac7|imgt:development_technology| VelocImmune® imgt:IgG1-kappa-%5BscFv%5D2-kappa_1196|http://semanticscience.org/resource/SIO_000291|imgt:bispecific imgt:StudyProduct_e96ded07-239f-343d-ac18-db63ba41c6cf|rdfs:label|StudyProduct_e96ded07-239f-343d-ac18-db63ba41c6cf imgt:StudyProduct_1b00576b-2129-3498-918b-8a14bbbc510f|imgt:isStudyProductOf|imgt:Product_fc42260f-2c18-39ae-b730-f7c667362547 imgt:Product_54b15dd3-f3e4-37c7-845f-2fb3af430183|imgt:isProductOf|imgt:mAb_741 imgt:M|rdf:type|imgt:C-RegionExonLabel imgt:StudyProduct_07c0e9b8-92c6-3c90-8d18-9f8cad364ddf|imgt:hasDecision|_:B007c49514bc2a0dfaa3a8b6009e99aee imgt:StudyProduct_9a2b5a71-1177-36a9-b7ba-340e1d5099e9|imgt:isStudyProductOf|imgt:Product_9167f067-90ce-3085-a54d-a51746667cfb imgt:StudyProduct_b8cb6d97-8a7b-3666-a4f8-691adcd82301|imgt:hasDecision|_:B4ca8d387a7b26c51502a9c164f15c7b7 imgt:IgG1-kappa-2cys-drug_815|imgt:isMabReceptorOf|imgt:mAb_815 imgt:mAb_300|imgt:imgt_note| company: also Takeda Pharmaceutical Company Limited, Osaka, Japan (in-house) Millennium Pharmaceuticals, Inc. is a subsidiary of Takeda Pharmaceuticals Takeda Pharmaceuticals U.S.A., Inc. is a wholly owned subsidiary of Takeda Pharmaceutical Co. Ltd. ENTYVIO™ is a trademark of Millennium Pharmaceuticals Inc. and is used under license by Takeda Pharmaceuticals America, Inc. imgt:Clone_436|rdfs:label|Clone_436 imgt:Construct_923|rdfs:label|Construct_923 imgt:mAb_958|imgt:inn_name|mirzotamab imgt:mAb_2|rdf:type|obo:NCIT_C1909 imgt:VH-VH|rdf:type|imgt:ConstructLabels imgt:IgG1-kappa-4cys-drug_1274|imgt:isMabReceptorOf|imgt:mAb_1274 imgt:Product_a99a661f-dfac-39f3-8f7d-abb5c67d65e2|imgt:isProducedBy|imgt:Scotgen_Biopharmaceuticals_Ltd imgt:IgG2-kappa_723|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG2-kappa.png imgt:StudyProduct_8889d288-1776-3c68-a627-317a34dc1c95|imgt:application_type|Therapeutic imgt:Subgroup|rdfs:label|Subgroup imgt:Construct_763|imgt:isConstructOf|imgt:IgG1-kappa_763 imgt:IgG4-kappa_968|imgt:hasConstruct|imgt:Construct_968 pubmed:7608568|dc:contributor|Hale C. imgt:Construct_910|obo:BFO_0000051|imgt:Segment_910_1 imgt:Product_5dde1122-ca49-3ad6-8e30-d28049e1461d|imgt:commun_name|Angiocept imgt:Product_0441025e-717d-338b-a029-f8226d8b249a|imgt:hasStudyProduct|imgt:StudyProduct_0441025e-717d-338b-a029-f8226d8b249a obo:NCIT_C158746|rdf:type|owl:Class _:Bc5cfbf02cf6038f0b95bcb2e41df131e|imgt:isDecisionOf|imgt:StudyProduct_5a0cba82-db5d-38b2-aa35-2dd98c602d95 imgt:StudyProduct_f7561f72-0990-36e2-8c23-3a140fc30e6f|imgt:hasClinicalPhase|imgt:Discontinued imgt:Septic_shock_MSS_(meningococcal_septic_shock)|rdfs:label|Septic_shock_MSS_(meningococcal_septic_shock) imgt:Segment_969_1|imgt:has_rank|1 imgt:Clone_717|rdfs:label|Clone_717 imgt:StudyProduct_32c61a15-2c8b-3f79-bbad-89bdad015cc7|imgt:isStudyProductOf|imgt:Product_7a3ec779-a1bd-30e8-a7a2-4a6524b06459 imgt:StudyProduct_bf877fc3-bba7-3243-be35-0482d4c871ce|imgt:isStudyProductOf|imgt:Product_9d05b768-40c8-3287-9fc9-b1c8d5a35139 imgt:Product_9077122f-d92c-3a25-993f-18def51278f5|imgt:commun_name|RO5520985 imgt:IgG1-nd_MM_312|imgt:conjugated_with| chelator pentetate (DTPA) imgt:Segment_872_3|rdfs:label|Segment_872_3 imgt:Clone_435|rdf:type|obo:NCIT_C37925 imgt:IgG1-kappa_903|rdf:type|imgt:MAbReceptor imgt:Chronic_lymphocytic_leukemia_(CLL)|imgt:isClinicalIndicationOf|imgt:StudyProduct_7314f845-4d5f-37ea-82dd-ea3d9b47c86a imgt:Product_a1b25bb3-97f5-363a-8463-339103288cd8|imgt:hasStudyProduct|imgt:StudyProduct_735c0bc0-0411-315c-9537-87ebbfd1c806 imgt:CD5|obo:RO_0002162|imgt:Homsap imgt:9689|imgt:isImgtStructureEntryOf|imgt:mAb_453 obo:NCIT_C174619|rdfs:subClassOf|obo:NCIT_C1909 imgt:Construct_297|imgt:isConstructOf|imgt:IgG1-kappa_297 imgt:StudyProduct_2314246e-4d62-3512-9c45-8393eff5d5e5|rdfs:label|StudyProduct_2314246e-4d62-3512-9c45-8393eff5d5e5 imgt:mAb_532|rdf:type|obo:NCIT_C101524 _:Be23376124e5f0e31df747ba78b3da60a|imgt:isDecidedBy|imgt:FDA imgt:Segment_423_1|imgt:hasImgtLabel|imgt:IgG4-kappa imgt:Segment_214_2|rdfs:label|Segment_214_2 imgt:StudyProduct_8bce3faa-595c-365b-93be-c8b34c755322|imgt:isStudyProductOf|imgt:Product_550b04fe-bcb2-3cf8-ab43-92130dafa2b3 imgt:ChainType|owl:disjointWith|imgt:ConfigurationType imgt:VACLabel|rdfs:subClassOf|imgt:StructureLabels imgt:Construct_725|rdf:type|imgt:Construct imgt:StudyProduct_c8410db6-e214-3133-9a26-8eee32338034|rdf:type|obo:NCIT_C174271 imgt:Product_b9d6b5b2-5634-3387-bfc9-34637876dd2c|rdfs:label|Product_b9d6b5b2-5634-3387-bfc9-34637876dd2c imgt:StudyProduct_2d05efe7-5286-304e-b7ab-f9b4a8c4e937|rdfs:label|StudyProduct_2d05efe7-5286-304e-b7ab-f9b4a8c4e937 imgt:StudyProduct_b5a3e660-80fb-34f2-91b4-51026be46ae9|imgt:hasClinicalPhase|imgt:Phase_I imgt:Construct_952|obo:BFO_0000051|imgt:Segment_952_1 imgt:IgG1-nd_20|imgt:hasConstruct|imgt:Construct_20 imgt:Merkel_cell_carcinoma_(MCC)_metastatic|imgt:isClinicalIndicationOf|imgt:StudyProduct_eddce4b1-d3b9-3401-aa99-97fb0942bd9a _:Bee448fd151a94d6b508e22a7e73d08e5|imgt:isDecisionOf|imgt:StudyProduct_0f7055d8-c758-3097-87c0-4548bbf4491a imgt:StudyProduct_ce2a9107-8d5c-351f-b0b8-b0e9eb71adbd|imgt:development_technology| GlycoExpress™ imgt:Product_e8e2ee19-1c69-36da-bcdc-799a693e4f34|imgt:isProductOf|imgt:mAb_344 imgt:LRR23|skos:definition|Leucine-rich repeat imgt:mAb_155|imgt:clinical_trials|10 studies found, 2 recruiting imgt:Product_0d23f5a7-b8cb-3eb8-ba07-41a57852fdf3|imgt:commun_name|NNC-0141-0000-0100 imgt:StudyProduct_80cc923e-ef63-348c-ac5b-d5fffb82ada1|imgt:hasDecision|_:B1693c3b9785498f649445f9e2e1139af _:Bf058fcc2ea44da4bf609fa7bdc5a2bcd|imgt:isDecidedBy|imgt:FDA imgt:Astellas_Pharma_Inc|imgt:produces|imgt:Product_93e98daf-0377-30bc-900c-0e4a06d486e6 imgt:Segment_1174_1|rdf:type|imgt:Segment imgt:Product_e9e52bcc-24ec-39dc-8de4-b4ba591c6845|imgt:hasStudyProduct|imgt:StudyProduct_7d89203d-92fb-39aa-bf64-5c9f9bd8a413 imgt:D-sequence|rdfs:label|D-sequence imgt:mAb_966|imgt:inn_recommended_list|83 (2020) imgt:StudyProduct_8c392433-f79a-3598-bd21-e7d09a590193|rdf:type|obo:NCIT_C174271 imgt:Product_198cee67-8852-3d8d-94e8-48fa692148e1|rdfs:label|Product_198cee67-8852-3d8d-94e8-48fa692148e1 imgt:Clone_141|imgt:isOriginCloneOf|imgt:mAb_141 imgt:mAb_607|rdf:type|obo:NCIT_C166535 imgt:Clone_88|obo:RO_0002162|imgt:Musmus imgt:StudyProduct_23e351ab-c13b-3fcd-a885-935151f0ec57|imgt:isStudyProductOf|imgt:Product_3d84c16b-3f37-3fd2-9308-fb662b4b198e imgt:mAb_465|imgt:hasImgtStructureEntry|imgt:9757 imgt:Memorial_Sloan-Kettering_Cancer_Center|imgt:produces|imgt:Product_1bac8223-af41-3c21-9a31-33d023358027 imgt:Product_17ddf92e-c382-3c3c-b38b-fe0f24dae88d|imgt:isProducedBy|imgt:Seattle_genetics_Inc imgt:Construct_165|obo:BFO_0000051|imgt:Segment_165_1 imgt:IgG2-lambda_451|obo:RO_0002162|imgt:Homsap imgt:mAb_262|imgt:inn_name|exbivirumab imgt:Product_c7359b30-f05b-3766-9171-fb55d36b7b20|imgt:isProducedBy|imgt:BeiGene imgt:Segment_289_1|imgt:hasImgtLabel|imgt:CD4 imgt:J-C-REGION|skos:definition|coding region of an IG or TR that comprises J-REGION and C-REGION, in spliced cDNA or in artificially spliced gDNA imgt:IgG1-kappa_1078|rdfs:comment|IgG1 - kappa imgt:StudyProduct_0e404088-fe07-3e25-8630-993e3507585c|rdfs:label|StudyProduct_0e404088-fe07-3e25-8630-993e3507585c _:Bb0c40a4bdd3e26aefb060d0f21476b33|imgt:isDecisionOf|imgt:StudyProduct_8fff197f-de8f-3c2d-a676-b34f313abb75 imgt:Product_cdc45b30-bcf4-349d-8058-1bb480d4bfe2|rdf:type|obo:NCIT_C51980 imgt:Segment_819_2|rdf:type|imgt:Segment imgt:StudyProduct_cf69c47f-5cad-39c6-a803-971560bf4b0d|imgt:hasClinicalIndication|imgt:Cancers_gastric imgt:C-GAMMA-2|skos:definition|C-DOMAIN of a TR-GAMMA-2 chain imgt:Construct_951|imgt:isConstructOf|imgt:IgG1-kappa_951 imgt:IgG1-kappa_80|http://semanticscience.org/resource/SIO_000291|imgt:ERBB2 imgt:mAb_235|imgt:hasProduct|imgt:Product_b7880def-b276-350c-b17c-1e311165b834 imgt:IgG1-lambda_348|obo:RO_0002162|imgt:Homsap imgt:StudyProduct_bd276df3-9f9e-34f3-add1-266cb6c98abe|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_8fff197f-de8f-3c2d-a676-b34f313abb75|imgt:application_type|Therapeutic imgt:Product_0061a6f8-1d2e-3272-82b4-cf993d16ec5d|imgt:hasStudyProduct|imgt:StudyProduct_a8d61298-870e-3700-bead-ef6b98e5f318 imgt:StudyProduct_173e4780-70d0-3f22-b92a-229030996299|imgt:application_type|Therapeutic imgt:StudyProduct_d2433268-2582-3566-bb16-4c56a6262e4c|rdfs:label|StudyProduct_d2433268-2582-3566-bb16-4c56a6262e4c imgt:StudyProduct_ca66ee28-0fc6-37ba-82aa-15dacaa9a9c3|imgt:hasClinicalIndication|imgt:Cholangitis_primary_sclerosing_(PSC) imgt:V-Lambda-VH__V-Kappa-VH|rdf:type|imgt:SegmentLabels imgt:IgG1-kappa_554|imgt:hasConstruct|imgt:Construct_554 imgt:9468|imgt:isImgtStructureEntryOf|imgt:mAb_408 imgt:LRRV4|skos:definition| imgt:Product_0c4ce40c-4004-3873-ac20-3d6e604874e8|imgt:commun_name|coagulation Factor IX (recombinant)- Fc fusion protein imgt:V-KAPPA-C-LAMBDA|skos:definition|Chain comprising a V-KAPPA and a C-LAMBDA domains imgt:Construct_896|obo:BFO_0000051|imgt:Segment_896_1 imgt:Clone_1227|imgt:clone_name|4BD10-073 imgt:Wnt_ligands|imgt:isTargetOf|imgt:FPIA_%5BPROTEIN%5D2-FC_475 imgt:CD3E|imgt:isTargetOf|imgt:(scFv-heavy-kappa)-(scFv-heavy-lambda)_838 imgt:Novartis_Pharmaceuticals_Corp|imgt:produces|imgt:Product_c9cafb67-7c5b-36ee-93fb-4c7df9648b85 imgt:Symphogen|imgt:produces|imgt:Product_9c9b4e88-8d3d-383a-92ba-bdb79b4dd491 imgt:IgG1-kappa_464|imgt:hasConstruct|imgt:Construct_464 imgt:mAb_249|imgt:centerwatch_link|http://www.centerwatch.com/drug-information/fda-approvals/drug-details.aspx?DrugID=1127 imgt:FLT1|obo:RO_0002162|imgt:Homsap imgt:L-V-D-J-C-chain|dc:identifier|imgt_000027 imgt:StudyProduct_29e10680-7e7d-30a4-9681-0ec6a25c7fed|rdfs:label|StudyProduct_29e10680-7e7d-30a4-9681-0ec6a25c7fed imgt:mAb_505|imgt:imgt_note| KaloBios' Humaneering™ technology uses bacterial expression systems to produce antibodies that are high affinity, but close to human germline sequences. imgt:IgG4-kappa_1010|imgt:hasMolecularComponent|imgt:IG obo:NCIT_C121775|rdf:type|owl:Class imgt:Clone_213|obo:RO_0002162|imgt:Homsap imgt:Cancers_bladder|imgt:clinical_domain|Oncology imgt:StudyProduct_be02d32a-6ad4-379d-9706-be3394ebebfc|imgt:hasClinicalIndication|imgt:IgE_mediated_allergies imgt:PRLR|imgt:isTargetOf|imgt:IgG1-kappa_858 imgt:TNFSF14|obo:RO_0002162|imgt:Homsap imgt:mAb_911|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=911 imgt:10113|rdfs:label|10113 imgt:PEPTIDE-B2M-I-ALPHA|skos:definition|MH chain or receptor comprising one I-ALPHA domain with a covalently linked peptide and B2M imgt:IgG1-kappa_1093|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:IgG1-kappa_64|rdf:type|imgt:MAbReceptor imgt:Product_d7375334-d0db-32f3-81ba-3cfa540a5cf4|rdf:type|obo:NCIT_C51980 imgt:IL6|skos:definition|Interleukin-6 chain or receptor imgt:mAb_384|imgt:inn_number|9431 imgt:Tanox_Inc|imgt:produces|imgt:Product_4e8c6419-bb31-3dc4-81fe-a499fde05f03 imgt:Fc-Gamma-2-a|rdfs:label|Fc-Gamma-2-a imgt:StudyProduct_38d44c39-7af5-3adc-bd30-2bc14412d098|imgt:hasDecision|_:Ba165750ffa7c982dd2c29fae1735c9e1 imgt:Clone_382|rdf:type|obo:NCIT_C37925 imgt:mAb_663|imgt:inn_name|ranevetmab imgt:INTEGRIN-ALPHA-L|skos:definition|integrin chain imgt:Melanoma_with_nodal_involvement_after_surgical_resection|rdf:type|obo:NCIT_C185637 imgt:StudyProduct_bfdb2eeb-9ddd-3208-8be9-8f9cb236e523|imgt:hasDecision|_:Bcc84cc2c449124b1183d754136d58601 imgt:9757|rdfs:label|9757 imgt:Fab-G1-kappa_316|rdfs:label|Fab-G1-kappa_316 imgt:Genrix_(Shanghai)_Biopharmaceutical|rdfs:label|Genrix (Shanghai) Biopharmaceutical imgt:Product_c92f28b1-5553-3365-b529-29749116a0bc|imgt:isProductOf|imgt:mAb_532 imgt:Construct_271|rdf:type|imgt:Construct imgt:Product_d1e214ac-e907-3588-8bc9-50d70143df9a|imgt:isProducedBy|imgt:Genexine imgt:Segment_360_1|obo:BFO_0000050|imgt:Construct_360 imgt:Segment_262_1|imgt:hasImgtLabel|imgt:IgG1-lambda imgt:StudyProduct_4a268328-5817-3e44-bec9-212e9c95064d|imgt:application_type|Therapeutic imgt:Product_a5c1a1b9-506a-361d-a62c-eee6f10d449a|imgt:commun_name|GR-1501 imgt:Astellas_Pharma_US_Inc|imgt:produces|imgt:Product_62e555bc-de18-34ed-b8f6-f3695acdd1ce imgt:Product_ce609b1d-7bd5-3f55-9d6a-288f1cb926aa|imgt:isProducedBy|imgt:Fresenius_Biotech_GmbH imgt:PROTEIN_5_1163|imgt:hasConstruct|imgt:Construct_1163 imgt:Myasthenia_gravis_(MG)|rdfs:label|Myasthenia_gravis_(MG) _:B184659daf20e103d54f208ab569686a7|imgt:hasDesignation|imgt:Orphan_drug imgt:J-C-REGION|rdfs:label|J-C-REGION imgt:Segment_190_1|rdfs:label|Segment_190_1 imgt:Segment_469_1|imgt:has_rank|1 imgt:IgG1-kappa-4cys-drug_668|rdfs:comment|IgG1 - kappa - 4cys - drug imgt:IgG2-kappa_102|imgt:hasMolecularComponent|imgt:IG imgt:Psoriasis|rdfs:label|Psoriasis imgt:Product_c9f2fb89-0971-33be-b453-f94d57bafe91|imgt:hasStudyProduct|imgt:StudyProduct_e15b2151-8965-350c-87ec-1241381bb101 imgt:Product_89e80ca8-7101-3ea6-b527-9c007f878e2b|imgt:commun_name|TTI-621-01 obo:NCIT_C174929|rdf:type|owl:Class imgt:StudyProduct_cad06487-fba8-32fe-ac47-aae7c63a6693|imgt:hasClinicalPhase|imgt:Phase_II imgt:GAS6|rdfs:label|GAS6 imgt:IgG1-kappa_1195|imgt:hasConstruct|imgt:Construct_1195 imgt:Prestige_Biopharma|imgt:produces|imgt:Product_55b8a3e2-4377-316b-b207-25ad9507669a imgt:StudyProduct_f754ce8a-da64-30d3-9f52-2a84188e22ff|imgt:hasClinicalIndication|imgt:Cancers_colorectal_(CRC) imgt:mAb_772|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=772 imgt:Anemia_associated_with_end_stage_renal_disease|rdfs:label|Anemia_associated_with_end_stage_renal_disease imgt:MH2-ALPHA_BETA|imgt:describes|imgt:MH2 imgt:Allergic_asthma|imgt:isClinicalIndicationOf|imgt:StudyProduct_16d8d743-6f76-3228-86d8-fdfad4ae7eae imgt:Construct_1285|rdfs:label|Construct_1285 imgt:IgG1-kappa_412|imgt:hasConstruct|imgt:Construct_412 imgt:StudyProduct_b35fef56-9616-3739-b99e-e60d25ac99ff|imgt:isStudyProductOf|imgt:Product_198cee67-8852-3d8d-94e8-48fa692148e1 imgt:Product_268e56a0-2bc3-3846-afaa-4a519b4838fe|imgt:commun_name|KY1005 imgt:Product_84e76124-e7a6-3d53-bb0d-67db69ff6aa5|imgt:commun_name|CAT-192 imgt:StudyProduct_3ade6364-93b7-321a-9b05-11dd7e21958f|imgt:isStudyProductOf|imgt:Product_be140b70-fccf-3adc-ab0e-066855350e81 imgt:StudyProduct_bb657515-54e5-392c-a891-61c8e3ea325b|imgt:application_type|Therapeutic imgt:MAbReceptor_239|obo:RO_0002162|imgt:Hum imgt:mAb_134|rdf:type|obo:NCIT_C1909 imgt:IgG4-kappa_1210|obo:RO_0002162|imgt:Homsap pubmed:1350088|imgt:isBibliographicReferenceOf|imgt:mAb_98 imgt:FC-ALPHA-2|rdfs:label|FC-ALPHA-2 imgt:Multiple_myeloma_(MM)|imgt:isClinicalIndicationOf|imgt:StudyProduct_a653ecce-5953-3e12-95f3-70101cdfde28 imgt:Sinocelltech_Ltd|imgt:produces|imgt:Product_12be981a-d52d-3197-b2a3-b970642e0c79 imgt:IgG1-kappa_590|obo:RO_0002162|imgt:Hum _:B0cf5d79f6c48f898d1f188e28f4fa573|dc:date|2018-06-18 imgt:StudyProduct_5654df68-9e63-3113-a117-b2c763657f36|imgt:isStudyProductOf|imgt:Product_8c9ef270-e03e-375b-ae61-95678879bb35 imgt:Segment_678_1|obo:BFO_0000050|imgt:Construct_678 imgt:IgG4-kappa_325|rdfs:label|IgG4-kappa_325 imgt:9123|rdfs:label|9123 imgt:StudyProduct_5a6137d4-60d5-3de5-934c-96a3a1bbbd70|imgt:hasClinicalPhase|imgt:Phase_M imgt:Construct_593|obo:BFO_0000051|imgt:Segment_593_1 imgt:StudyProduct_dfce9127-aae8-3b59-a5aa-7955783ed7ce|imgt:isStudyProductOf|imgt:Product_0650976e-e362-337e-ab9a-2cf669b1c2b0 imgt:mAb_698|rdf:type|obo:NCIT_C1909 imgt:Product_5994f2d0-2c12-3fdb-820c-747cc0c851a0|rdfs:label|Product_5994f2d0-2c12-3fdb-820c-747cc0c851a0 imgt:Product_a8c8c8c2-d189-3ad8-a6d9-9c8f8d8c89c0|imgt:isProductOf|imgt:mAb_365 imgt:Clone_1040|rdf:type|obo:NCIT_C37925 imgt:IgG1-kappa-4cys_1059|rdf:type|imgt:MAbReceptor imgt:IG-GAMMA-3_LAMBDA|imgt:describes|imgt:IgG3_Lambda imgt:F(AB%27)2-ALPHA-1_LAMBDA|rdf:type|imgt:IGProteolyticFragmentLabel imgt:IgG1-nd_743|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-nd.png imgt:mAb_20|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=20 imgt:Clone_146|imgt:clone_name|7E3 imgt:Construct_18|obo:BFO_0000051|imgt:Segment_18_1 imgt:mAb_824|rdf:type|obo:NCIT_C169929 imgt:Cambridge_Antibody_Technology|imgt:produces|imgt:Product_5994f2d0-2c12-3fdb-820c-747cc0c851a0 imgt:mAb_1158|imgt:hasOriginClone|imgt:Clone_1158 imgt:Product_c9cafb67-7c5b-36ee-93fb-4c7df9648b85|imgt:commun_name|SDZ MSL 109 imgt:Construct_1030|imgt:hasImgtLabel|imgt:IgG4-kappa imgt:Product_d20d5641-8781-3f8c-9a35-3836a5995abc|imgt:isProducedBy|imgt:AbbVie_Inc imgt:IgG1-kappa_610|rdf:type|imgt:MAbReceptor imgt:Segment_536_1|rdf:type|imgt:Segment _:B952c2d4a4ffc64c5f88766f0bf3bea10|imgt:hasDesignation|imgt:Orphan_drug imgt:TR-V-GAMMA-C-BETA-2|rdfs:label|TR-V-GAMMA-C-BETA-2 imgt:mAb_280|imgt:clinical_trials|326 studies found, 35 recruiting imgt:StudyProduct_06448ca3-ffe2-3a00-ba78-ba6b983a12de|imgt:application_type|Therapeutic imgt:Construct_913|imgt:isConstructOf|imgt:IgG1-kappa_913 imgt:Product_46489dd5-dbbb-3ac3-a0f1-64d45c1d847d|rdf:type|obo:NCIT_C51980 imgt:mAb_1167|imgt:hasProduct|imgt:Product_9dc2e6e7-02dc-385a-9448-66778b7d71e6 imgt:11699|rdfs:label|11699 imgt:mAb_533|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=533 imgt:Nasal_polyposis|imgt:clinical_domain|Immunology imgt:StudyProduct_f161f58e-d105-358b-862d-7b59e3a2fc39|imgt:isStudyProductOf|imgt:Product_76eaaae8-3383-396f-85e7-82ee6811700f imgt:CD33|imgt:isTargetOf|imgt:IgG1-kappa_53 imgt:mAb_611|imgt:hasProduct|imgt:Product_26793454-2d17-3d3e-a99a-1648d65e5dd2 imgt:Segment_226_1|rdf:type|imgt:Segment imgt:M1-PRIME|skos:definition|5' extension of the M1 exon of the IGHE C-GENE-UNIT of human and other primates, encompassing 52 codons and delimited by an upstream alternative ACCEPTOR-SPLICE, or corresponding region in cDNA imgt:ABL1|skos:definition|Tyrosine-protein kinase ABL1 imgt:mAb_1058|imgt:hasMabReceptor|imgt:scFv-scFv-scFc_kappa-lambda_1058 imgt:mAb_575|rdfs:label|mAb_575 imgt:Product_1316e8fc-c324-306e-97c8-ef0e1de0f57c|imgt:isProductOf|imgt:mAb_1256 imgt:Segment_357_1|imgt:has_rank|1 imgt:IgG1-kappa_577|imgt:hasConstruct|imgt:Construct_577 imgt:Construct_974|obo:BFO_0000051|imgt:Segment_974_1 imgt:StudyProduct_a4a8aabd-1831-3836-9235-8d194bfab559|imgt:isStudyProductOf|imgt:Product_5038f9ea-65d4-3eb8-b074-e25dab59e6c5 imgt:Product_77b1d31f-8986-3dd9-86b7-51b56818e7a2|rdfs:label|Product_77b1d31f-8986-3dd9-86b7-51b56818e7a2 imgt:StudyProduct_e4eea69e-43e4-3e5d-aef6-5c28239018ea|imgt:hasClinicalPhase|imgt:Phase_I imgt:Segment_1170_1|rdfs:label|Segment_1170_1 imgt:F(ab’)2-Alpha-1_Lambda|imgt:isDescribedBy|imgt:F(AB')2-ALPHA-1_LAMBDA imgt:mAb_838|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=838 imgt:Segment_221_1|obo:BFO_0000050|imgt:Construct_221 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imgt:StudyProduct_d784ef39-1f29-32db-b2f2-bce71355cab9|imgt:hasClinicalPhase|imgt:Phase_I imgt:11433|rdfs:label|11433 imgt:mAb_422|imgt:inn_proposed_list|107 (2012) imgt:TNFRSF17|imgt:isTargetOf|imgt:scFv-scFv-scFc_kappa-lambda_1058 imgt:Segment_229_1|imgt:has_rank|1 _:Bbe2a3440a9ba62ac28d059c0075d7090|dc:date|2016-07-27 imgt:Product_8b6edb53-a492-3ff2-8c0e-287420f9b486|imgt:comercial_name|ZYNLONTA™ imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_bf0c6988-2641-3c0a-8840-60eccf82f63b imgt:Segment_853_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:MAbReceptor_63|imgt:hasMolecularComponent|imgt:IG imgt:StudyProduct_05ddb4d2-a6fb-3832-9fe2-3592ea8df038|imgt:hasClinicalPhase|imgt:Phase_M imgt:Construct_979|imgt:isConstructOf|imgt:IgG1-kappa_979 imgt:ITGAL|rdf:type|obo:NCIT_C25702 imgt:StudyProduct_4633b912-debb-31fd-875f-fe1e9822873b|rdf:type|obo:NCIT_C174271 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imgt:StudyProduct_2a72939a-3224-3a2d-a0ae-f00eb851199e|imgt:hasClinicalIndication|imgt:Extranodal_NK/T-cell_lymphoma_(ENKTL) imgt:mAb_451|imgt:hasProduct|imgt:Product_295d81a6-22b0-3a10-a52e-d3ea9fcfd5cc imgt:Segment_963_1|imgt:has_rank|1 imgt:Nordic_Nanovector_ASA|imgt:produces|imgt:Product_40fd3b5d-f917-3fed-97f6-62ec12bc834e imgt:IgG1-kappa_1060|obo:RO_0002162|imgt:Hum imgt:CY-PART4|skos:definition|exon or part of exon of C-GENE-UNIT, GENE-UNIT or L-GENE-UNIT, coding the fourth part of the CYTOPLASMIC-REGION, in gDNA imgt:11116|rdf:type|obo:NCIT_C25402 obo:NCIT_C152236|rdf:type|owl:Class imgt:11044|rdfs:label|11044 imgt:ENZ-CARRIER_BIG_687|imgt:isMabReceptorOf|imgt:mAb_687 imgt:StudyProduct_87085fe4-4008-3dc3-9e2d-43b31799aef5|rdf:type|obo:NCIT_C174271 imgt:mAb_591|imgt:inn_recommended_list|76 (2016) obo:NCIT_C38717|rdf:type|owl:Class imgt:mAb_1196|imgt:inn_proposed_list|125 (2021) imgt:Clone_1135|imgt:clone_name|F3cp63STcp95-cp06 imgt:Construct_575|rdf:type|imgt:Construct imgt:StudyProduct_1f2769b7-83c0-3866-baea-c8c8caad6759|imgt:isStudyProductOf|imgt:Product_d7375334-d0db-32f3-81ba-3cfa540a5cf4 imgt:StudyProduct_93876f3d-de44-338d-8cf8-62103fc576df|imgt:isStudyProductOf|imgt:Product_14257a8f-cd9a-382a-84d4-a9b2019dd24a imgt:Segment_258_1|obo:BFO_0000050|imgt:Construct_258 imgt:Fab-Gamma-2-b_Lambda|imgt:isDefinedBy|imgt:IG-Light-Lambda-IGL _:Be8a20742098bdb2bb357b213131a19ec|dc:date|1997-10-06 imgt:Segment_86_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:StudyProduct_9f557969-ab56-3ded-bc53-cb04c365c2b3|rdfs:label|StudyProduct_9f557969-ab56-3ded-bc53-cb04c365c2b3 imgt:Segment_937_1|imgt:has_rank|1 imgt:IgG1-kappa_64|rdfs:label|IgG1-kappa_64 imgt:mAb_1029|rdfs:label|mAb_1029 imgt:Ridgeback_Biotherapeutics_LP|rdfs:label|Ridgeback Biotherapeutics, LP imgt:StudyProduct_610139e9-1ad4-34aa-99d3-50d54729d262|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_7d89203d-92fb-39aa-bf64-5c9f9bd8a413|imgt:development_technology| Abgenix's XenoMouse® imgt:Segment_130_1|imgt:has_rank|1 imgt:Product_0d4c352a-e8e7-3a46-bfd9-1bf54a8e01ea|imgt:isProductOf|imgt:mAb_330 imgt:Segment_122_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:mAb_1004|imgt:hasOriginClone|imgt:Clone_1004 imgt:FAB-GAMMA-2-A_LAMBDA|rdf:type|imgt:StructureLabels imgt:StudyProduct_6a59b155-d8b1-35ec-952e-799b7e86acb1|rdf:type|obo:NCIT_C174271 imgt:mAb_159|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=159 _:Be16a091924adb04ee88db3e3447080c7|imgt:hasStatut|imgt:approval imgt:mAb_474|imgt:inn_number|9800 imgt:Cancers_colorectal_(CRC)|imgt:isClinicalIndicationOf|imgt:StudyProduct_d17f568c-2f95-3814-9c7b-159fefc500e3 imgt:SNP|obo:RO_0002162|imgt:Homsap imgt:Product_e307cb3e-aef8-35ec-8bfb-bee27d4d2030|rdf:type|obo:NCIT_C51980 obo:NCIT_C172746|rdf:type|owl:Class imgt:Construct_595|rdf:type|imgt:Construct imgt:StudyProduct_6bee57a7-bbc1-366d-8257-595e1dceb7b6|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_1eba0950-a429-3c1f-b1b1-a7e4f37e8cab|imgt:isStudyProductOf|imgt:Product_2b19c2f5-d596-3bcf-8b1b-86730cfcfc4b imgt:StudyProduct_f47361f4-373b-374c-bd2d-cb5a37551e7c|imgt:hasClinicalIndication|imgt:Cancers_anal imgt:PhaseBio|imgt:produces|imgt:Product_e975b070-9be2-38ce-bb6e-ecee5129340b imgt:StudyProduct_75b6a2b5-b839-3dba-a5e9-a51e3ee069fc|rdfs:label|StudyProduct_75b6a2b5-b839-3dba-a5e9-a51e3ee069fc imgt:Product_cebe55fc-cd34-3a4c-89a2-e598b65a8449|imgt:commun_name|Anti-CD200 imgt:KDR|skos:definition|KDR (kinase insert domain receptor, vascular endothelial growth factor receptor 2, VEGFR2, VEGF-R2, FLK1, CD309) imgt:Product_26793454-2d17-3d3e-a99a-1648d65e5dd2|imgt:commun_name|sLAG-3-Ig imgt:BMP10|rdf:type|obo:NCIT_C25702 imgt:mAb_18|imgt:inn_recommended_list|49 (2003) imgt:Product_d3c711cd-8848-34a6-85be-a70321305cd0|imgt:commun_name|ANB-030 imgt:StudyProduct_6b2977b7-c6a1-33d0-89f9-9dfc928a3a40|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_1ff5ecf2-e3c9-3646-9248-69820495c22f|imgt:development_technology| Medarex’s UltiMAb® imgt:StudyProduct_cf69c47f-5cad-39c6-a803-971560bf4b0d|imgt:hasDecision|_:B7bfd491e45f2f2ee7849622f0746ac58 imgt:StudyProduct_fc551c1a-d3e2-3628-a426-461f7d8ac6f0|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:Construct_542|imgt:hasImgtLabel|imgt:IgG1-kappa obo:NCIT_C97942|rdfs:subClassOf|obo:NCIT_C1909 imgt:Construct_968|imgt:isConstructOf|imgt:IgG4-kappa_968 imgt:IgG1-kappa_411|imgt:hasMolecularComponent|imgt:IG imgt:StudyProduct_a537c635-1641-3b72-aee4-80c8bf5556d3|imgt:hasDecision|_:B10d205784b642cdd59d99feb0c75703e imgt:Janssen_Biotech_Inc|imgt:produces|imgt:Product_36cb4986-4d03-31c7-b2d0-954c198844be imgt:PROTEIN_2ANDHALFREPEATS-PEG_275|imgt:hasMolecularComponent|imgt:RPI imgt:Product_d50fe58f-9435-33aa-a2dd-cdb13c40f840|imgt:hasStudyProduct|imgt:StudyProduct_7c608379-7a72-3348-bbf8-0b597847afa4 imgt:V-D-J-C-CLUSTER|owl:sameAs|obo:SO_0000531 imgt:IgG1-kappa_83|http://semanticscience.org/resource/SIO_000291|imgt:HCMV imgt:PROTEIN_1DOMAIN-PEG_637|rdf:type|imgt:MAbReceptor imgt:Crohn's_disease_(CD)|imgt:isClinicalIndicationOf|imgt:StudyProduct_1262459b-5fb7-3613-be73-bb5ee75f51e3 imgt:StudyProduct_a3800fc5-233c-3edd-bd1c-f42059b81c6a|imgt:hasClinicalIndication|imgt:Hypereosinophilic_syndrome_(HES) imgt:mAb_538|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=538 imgt:Product_c2f673d4-4d4a-3adb-886b-858a585b47df|imgt:isProductOf|imgt:mAb_997 imgt:mAb_154|rdf:type|imgt:INN imgt:Product_c9cafb67-7c5b-36ee-93fb-4c7df9648b85|rdf:type|obo:NCIT_C51980 imgt:Construct_239|obo:BFO_0000051|imgt:Segment_239_1 imgt:IgG1-lambda_1247|obo:RO_0002162|imgt:Homsap pubmed:24927856|dc:contributor|Mato AR imgt:StudyProduct_801c8339-57b5-3f8c-8836-5923647a48db|imgt:application_type|Therapeutic imgt:StudyProduct_cccb8781-4b8f-3c4b-96f1-dcb77db41d51|rdf:type|obo:NCIT_C174271 imgt:mAb_132|rdf:type|obo:NCIT_C1321 imgt:Product_49d0e51d-fc17-3c61-be0a-87eb08d806f8|imgt:commun_name|REGN-2222 imgt:IgG1-nd_39|http://semanticscience.org/resource/SIO_000291|imgt:EGFR imgt:Construct_274|obo:BFO_0000051|imgt:Segment_274_1 imgt:Segment_1171_1|obo:BFO_0000050|imgt:Construct_1171 imgt:I-ALPHA|skos:definition|MH1-Alpha chain comprising a G-ALPHA1, a G-ALPHA2 and a C-LIKE domains imgt:Construct_53|rdf:type|imgt:Construct imgt:StudyProduct_075258bb-8978-32df-ba1a-e24b9cbe38f8|imgt:hasClinicalPhase|imgt:Phase_M imgt:IgG1-kappa-4lys-drug_600|rdfs:label|IgG1-kappa-4lys-drug_600 imgt:StudyProduct_c8332a03-e7ae-3c3b-909b-b7aeff4285b8|rdfs:label|StudyProduct_c8332a03-e7ae-3c3b-909b-b7aeff4285b8 imgt:mAb_768|rdf:type|imgt:INN imgt:Clone_579|imgt:isOriginCloneOf|imgt:mAb_579 imgt:Product_6fc221fc-63c6-300f-8844-5210f60014c6|rdf:type|obo:NCIT_C51980 imgt:IgG1-kappa_661|obo:RO_0002162|imgt:Hum imgt:StudyProduct_aa504c9b-ee8c-379e-bf9d-7b3a22c05ac9|imgt:hasClinicalIndication|imgt:Asthma imgt:IgG1-nd_MM_307|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-nd_MM.png imgt:StudyProduct_d75165ab-4ffe-3b58-a051-77afd4e2bb75|rdf:type|obo:NCIT_C174271 imgt:mAb_802|imgt:hasImgtStructureEntry|imgt:10737 imgt:mAb_424|imgt:hasMabReceptor|imgt:IgG4-kappa_424 imgt:8713|imgt:isImgtStructureEntryOf|imgt:mAb_250 imgt:11672|imgt:isImgtStructureEntryOf|imgt:mAb_1172 imgt:Segment_812_1|imgt:has_rank|1 imgt:mAb_766|imgt:inn_number|10646 imgt:Anemia_autoimmune_hemolytic_(AIHA)|rdfs:label|Anemia_autoimmune_hemolytic_(AIHA) imgt:IgG2-kappa_975|imgt:hasConstruct|imgt:Construct_975 imgt:Clone_1157|imgt:isOriginCloneOf|imgt:mAb_1157 imgt:mAb_1215|rdfs:label|mAb_1215 imgt:Product_8faedd00-17b0-312c-ae14-110c5b02880a|imgt:comercial_name|CINQUIL™ imgt:Product_7c524e73-547d-3b09-baca-f38148653f91|imgt:commun_name|GSK 716155 imgt:IgG1-kappa_491|imgt:isMabReceptorOf|imgt:mAb_491 imgt:IgG1-kappa_321|obo:RO_0002162|imgt:Homsap imgt:mAb_41|rdf:type|obo:NCIT_C1909 imgt:mAb_470|imgt:hasImgtStructureEntry|imgt:9779 imgt:mAb_331|imgt:imgt_note| Sotatercept INN definition is the one amended in L104 (2010) and R65 (2011). Celgene is now part of Bristol-Myers Squibb (Press release, 20 November 2019) imgt:Chronic_kidney_disease_(CDK)|imgt:isClinicalIndicationOf|imgt:StudyProduct_7d67a48d-3457-3319-b4c3-2b01b733859c imgt:LINGO1|rdf:type|obo:NCIT_C25702 imgt:Product_0348fc3a-dd69-3bf2-bb93-d6d2b096d5f2|imgt:commun_name|AMG 110 imgt:Mesothelioma|imgt:isClinicalIndicationOf|imgt:StudyProduct_262a7474-b842-354e-9a7f-3b5d9c0e45d6 imgt:Solid_tumors|imgt:isClinicalIndicationOf|imgt:StudyProduct_e6f8d005-98be-31e4-9c9f-cee3e576b051 imgt:StudyProduct_53931e74-e525-3e5f-a76b-b4b9eef386f2|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:Product_bca639d9-3ea1-3a92-b97f-0d34a9d52fd8|rdfs:label|Product_bca639d9-3ea1-3a92-b97f-0d34a9d52fd8 imgt:IgG1-kappa_845|rdfs:label|IgG1-kappa_845 imgt:mAb_882|imgt:hasImgtStructureEntry|imgt:11159 imgt:mAb_832|imgt:hasImgtStructureEntry|imgt:11511 imgt:StudyProduct_dda793a3-6153-3e67-8e8c-30c859b184ba|imgt:hasClinicalIndication|imgt:West_Nile_Virus_Infection imgt:Affibody_AB|imgt:produces|imgt:Product_3fdea4e9-544f-3f36-93de-c10860b47fd8 imgt:Segment_1168_1|rdfs:label|Segment_1168_1 imgt:Product_0dea9063-7da8-3df3-9249-b5cddeecec56|imgt:commun_name|PankoMab-GEX imgt:StudyProduct_1b0dfb86-2a33-3fd6-9911-2b8048c77fd2|imgt:hasClinicalIndication|imgt:Juvenile_Idiopathic_Arthritis_(JIA) obo:NCIT_C170758|rdf:type|owl:Class imgt:StudyProduct_6a51865b-a2bb-3a85-9e96-4a425b1806c1|rdf:type|obo:NCIT_C174271 imgt:mAb_875|rdfs:label|mAb_875 imgt:StudyProduct_f74c0406-a8cf-360b-a0e5-687f8ccd98cd|imgt:hasDecision|_:B73097fcd66ac53f06b33f4bc64398d97 pubmed:27144973|dc:contributor|Broussas M imgt:mAb_349|imgt:inn_name|ensituximab imgt:FPIA_%5BPROT-PROT%5D2-FC_615|imgt:fused_with| Homo sapiens IGHG1 Fc (Fragment constant) imgt:StudyProduct_1affd692-dea5-3725-8845-f8fa9ca74d69|imgt:development_technology| Abgenix's XenoMouse® imgt:StudyProduct_7bad9e61-b26d-376c-b785-9c694f61a571|rdf:type|obo:NCIT_C174271 imgt:urushiol|rdf:type|obo:NCIT_C25702 imgt:mAb_1258|imgt:hasMabReceptor|imgt:IgG1-lambda-%5BscFv%5D2-kappa_1258 imgt:Lymphoma_follicular_(FL)|imgt:isClinicalIndicationOf|imgt:StudyProduct_14ef875e-bf47-3078-9f6e-3462f0e48969 imgt:mAb_570|imgt:clinical_trials|13 studies found, 1 recruiting imgt:IgG1-kappa_MM_126|rdfs:comment|IgG1-kappa_MM imgt:mAb_138|imgt:imgt_note| mAb radiolabelled used in radio-immuno-scintigraphy The chimeric mAb has been crystallized ( IMGT/3Dstructure-DB 1bbj ) imgt:IgG1-kappa_165|imgt:hasConstruct|imgt:Construct_165 imgt:Lymphoma_diffuse_large_B_cell_(DLBCL)|imgt:isClinicalIndicationOf|imgt:StudyProduct_a453b715-934b-3676-9258-792ea8fffdcf imgt:Product_df36c7dd-b2c5-31f0-8c96-9341a9d2efeb|imgt:isProductOf|imgt:mAb_703 imgt:Product_4391f6b4-98b1-38e2-94d2-967326f820fe|imgt:hasStudyProduct|imgt:StudyProduct_53334127-51ec-3e46-bb66-71919e3cce29 imgt:StudyProduct_c1f4369b-0842-3002-b808-9913ae773a47|imgt:hasClinicalIndication|imgt:Type_2_diabetes_(T2_DM) imgt:mAb_998|imgt:hasProduct|imgt:Product_80c5a255-5aa4-3782-9556-7a0618ee7c39 imgt:Segment_392_1|rdf:type|imgt:Segment imgt:Product_70626d7d-afcd-3d0c-944a-b65990e20e32|rdf:type|obo:NCIT_C51980 imgt:Product_e307cb3e-aef8-35ec-8bfb-bee27d4d2030|imgt:commun_name|KW0761 imgt:IgG1-kappa_28|imgt:hasConstruct|imgt:Construct_28 imgt:StudyProduct_c9cc9b8f-768e-34d7-8f47-1cb65379c659|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_7074878e-5024-3517-aad8-1d22b5ae0f39|imgt:hasClinicalIndication|imgt:Complement_component_deficiency imgt:StudyProduct_8d2d49c4-e64f-36b1-aa3d-14d44f9e7cb2|imgt:hasClinicalIndication|imgt:Rheumatoid_arthritis_(RA) imgt:Product_e9367e74-6980-33ff-980c-4e5c85c4ffeb|imgt:commun_name|60,3 imgt:StudyProduct_a6860c46-8ca9-3f3b-92a0-6aee7665ba18|rdf:type|obo:NCIT_C174271 imgt:Segment_730_1|imgt:segment_detail|23-617 imgt:9762|rdf:type|obo:NCIT_C25402 imgt:mAb_784|imgt:clinical_trials|15 studies found, 13 recruiting imgt:Clone_659|rdfs:label|Clone_659 imgt:mAb_661|imgt:clinical_trials|18 studies found, 13 recruiting _:B52ea4f1e08105c07e191ff491457772b|imgt:isDecisionOf|imgt:StudyProduct_422762cf-d030-3756-9850-2b63d3bd52b0 imgt:StudyProduct_c530d1d3-2c88-3698-a7d7-b829340f11ff|rdf:type|obo:NCIT_C174271 _:B17f9e03feebcc3a15f1123b88cd51821|rdf:type|obo:NCIT_C53285 imgt:11318|rdf:type|obo:NCIT_C25402 obo:NCIT_C171836|rdf:type|owl:Class imgt:mAb_637|imgt:imgt_note| A single, linear 20 KDa PEG covalently attached to the alpha amino group of the N-terminal amino acid. imgt:mAb_810|rdfs:label|mAb_810 imgt:PEPTIDE_705|imgt:isMabReceptorOf|imgt:mAb_705 imgt:mAb_1127|rdf:type|obo:NCIT_C157632 imgt:FCGRT|imgt:isTargetOf|imgt:FC-GAMMA-1_731 imgt:cDNA|rdf:type|imgt:MoleculeType imgt:mAb_421|rdf:type|obo:NCIT_C123730 imgt:StudyProduct_0f7eb5d2-25f4-3ec3-903d-96073744e63d|imgt:development_technology| MorphoSys's HuCAL® phage library imgt:Product_74def704-c24a-3618-abf3-e38e49ab0ee8|imgt:hasStudyProduct|imgt:StudyProduct_e7879970-9f95-3f40-9bfc-e60c454fd71c _:Bc281816125dbb9a20b5ac2bde3b14adb|imgt:isDecidedBy|imgt:FDA imgt:Construct_1259|imgt:isConstructOf|imgt:IgG1-kappa-4F-drug_1259 imgt:variable|skos:definition|Identifies a variable (V) gene, a gene that rearranges at the DNA level and codes the variable region of the variable domain of an IG or of a TR chain. imgt:Construct_30|rdf:type|imgt:Construct imgt:_CHOK1SV_(lacking_the_glutamine_synthetase_(GS)_gene)_cells|rdf:type|imgt:ExpressionSystem imgt:ConfigurationType|rdfs:label|ConfigurationType imgt:MET|imgt:isTargetOf|imgt:IgG1-kappa_654 imgt:Berlex_Inc|rdfs:label|Berlex Inc. imgt:Diabetic_macular_edema|imgt:isClinicalIndicationOf|imgt:StudyProduct_8ea9cb56-50d7-3016-a7f3-8606e22666dc imgt:Influenza_A_infection|imgt:isClinicalIndicationOf|imgt:StudyProduct_b97ea00c-a193-3e97-b1e7-738ccbd8aa85 imgt:StudyProduct_563dac3b-0d8b-31ed-b076-8a4cf3724d45|imgt:isStudyProductOf|imgt:Product_86b0d58e-a624-3f88-b243-f89121d692c5 imgt:StudyProduct_163e4859-4df9-3329-97e3-dc1e168bb762|rdf:type|obo:NCIT_C174271 imgt:Product_97d744b1-4bb8-3b77-b6fc-10c38a6bca9a|imgt:commun_name|PN0621 imgt:IgG1-kappa_297|obo:RO_0002162|imgt:Chi _:B1f9064a8a40f017c8da5b4e23906b3de|rdf:type|obo:NCIT_C53285 imgt:EX2B|rdfs:label|EX2B imgt:Segment_1047_1|rdf:type|imgt:Segment imgt:L-KAPPA-SCFV-HEAVY-KAPPA|rdf:type|imgt:ChainLabels imgt:PROTEIN_1DOMAIN_1235|rdfs:label|PROTEIN_1DOMAIN_1235 imgt:Product_befef2c3-f6db-347b-ad59-89c3a928207e|imgt:hasStudyProduct|imgt:StudyProduct_be05a673-0f5d-34f9-84d2-fbfe1a49194a imgt:StudyProduct_b8543b44-c170-31d9-9985-bdcaa45b9a1d|imgt:isStudyProductOf|imgt:Product_b9e8379b-d30f-37fb-ac2e-44ad77f3f669 imgt:StudyProduct_38193ef7-7070-3608-ab5c-cd67e024d8b4|rdfs:label|StudyProduct_38193ef7-7070-3608-ab5c-cd67e024d8b4 imgt:StudyProduct_0c23c19c-5024-3083-90b4-416d2c92751d|rdf:type|obo:NCIT_C174271 imgt:IG-Light-Kappa-IGKC|imgt:defines|imgt:Fab-Alpha-1_Kappa imgt:mAb_53|imgt:hasMabReceptor|imgt:IgG1-kappa_53 imgt:StudyProduct_7cce0a19-7542-3e6a-817e-a15921eca2f5|imgt:application_type|Therapeutic imgt:VH-VH%27_1014|obo:RO_0002162|imgt:Hum imgt:C5AR1|imgt:isTargetOf|imgt:IgG1-kappa_940 imgt:StudyProduct_dea7824a-be21-3d32-9b44-3eab8ad218c1|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_96603d21-ce18-3f87-9d06-4acc1b685b08|rdf:type|obo:NCIT_C174271 imgt:Product_5599efd0-7eee-32e0-ad93-253e80b8b7e3|imgt:hasStudyProduct|imgt:StudyProduct_7c3ef30a-9ded-3a0d-a265-52ddf17bf64a imgt:StudyProduct_a577ee5a-abd0-313b-8261-f46ea2830ac1|imgt:isStudyProductOf|imgt:Product_aee84d79-6a61-36d6-9514-5d5984e7e3f0 imgt:Product_be140b70-fccf-3adc-ab0e-066855350e81|rdf:type|obo:NCIT_C51980 imgt:_Sp2/0_mouse_hybridoma_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_806e3c6b-f05c-36ea-9c25-129a9939f774 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imgt:VEGFA|imgt:isTargetOf|imgt:FPIA_%5BPROTEIN_PROTEIN%5D2-FC-%5BPROTEIN%5D2_1228 imgt:Construct_676|imgt:isConstructOf|imgt:IgG4-nd_676 imgt:Segment_1162_2|imgt:segment_detail|Fc (Fragment constant) imgt:StudyProduct_e82fce6f-f9b1-3c8e-ba70-8a8f50d57e6f|rdf:type|obo:NCIT_C174271 imgt:MAbReceptor_345|rdfs:label|MAbReceptor_345 imgt:mAb_197|imgt:clinical_trials|7 studies found, 2 recruiting imgt:Product_f246242d-cc24-305b-8e9f-06e04804a59b|imgt:hasStudyProduct|imgt:StudyProduct_b15fa3dc-8f6b-39f0-a55e-0a40742c248c imgt:Product_8aedac6e-b419-31fb-9ff4-442f5cc9176a|imgt:comercial_name|CINQUIL™ imgt:StudyProduct_72ade6f5-f490-3433-ab6c-e2699b9107db|rdfs:label|StudyProduct_72ade6f5-f490-3433-ab6c-e2699b9107db imgt:CH1|rdf:type|imgt:ChainLabels imgt:Segment_1003_1|rdf:type|imgt:Segment imgt:Cancers_pancreatic|imgt:isClinicalIndicationOf|imgt:StudyProduct_d9ddb989-a3d8-3f9e-9503-fc4a15e9dd24 imgt:StudyProduct_c31a0ad2-8842-3796-8cdb-b4f729744076|rdf:type|obo:NCIT_C174271 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imgt:Stroke|imgt:isClinicalIndicationOf|imgt:StudyProduct_629b5f50-da7b-35be-ab43-a961802999fb imgt:IgG1-kappa_1255|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:mAb_146|imgt:inn_number|7200 imgt:Segment_1051_2|obo:BFO_0000050|imgt:Construct_1051 imgt:StudyProduct_521bdb6c-241f-3c8b-83bf-6f87a696275a|imgt:hasDecision|_:B0798134bf6f92e4647cb27459895158b imgt:Graft-versus-host_disease_(GvHD)|imgt:clinical_domain|Immunology imgt:IgG1-nd_6|imgt:hasMolecularComponent|imgt:IG imgt:FPIA_%5BPROTEIN-PROTEIN-PROTEIN-PROTEIN%5D2-FC_1158|imgt:hasConstruct|imgt:Construct_1158 imgt:Product_a9814a14-a170-37d5-97fd-0fe8732330c2|imgt:isProducedBy|imgt:AstraZeneca imgt:Diabetic_macular_edema|imgt:isClinicalIndicationOf|imgt:StudyProduct_9578ebf7-143d-3548-9867-706dd07f2f9a imgt:Product_befef2c3-f6db-347b-ad59-89c3a928207e|imgt:hasStudyProduct|imgt:StudyProduct_589b75c7-1ae4-35da-9033-6e3be2cba1a1 imgt:10103|imgt:isImgtStructureEntryOf|imgt:mAb_560 imgt:Multiple_myeloma_(MM)|imgt:isClinicalIndicationOf|imgt:StudyProduct_48474ed3-d570-312e-a6fb-683e3913eea7 imgt:StudyProduct_fb049423-02a4-3c71-b284-29932cb38182|imgt:hasClinicalPhase|imgt:Phase_M imgt:StudyProduct_4e0694fb-ee8d-3a3e-8aff-728d410b3829|imgt:isStudyProductOf|imgt:Product_b867f21e-ad50-386a-8346-0ac25d92425d imgt:PEPTIDE_711|rdfs:comment|PEPTIDE imgt:Nventa_Biopharmaceuticals_Corporation|imgt:produces|imgt:Product_8c770a12-7fc2-32b8-8008-b740990cf3b1 imgt:Severe_acute_respiratory_syndrome_coronavirus_2_(SARS-CoV-2)_infection_(COVID-19)|imgt:isClinicalIndicationOf|imgt:StudyProduct_06350178-995f-30ee-8f5b-7f9fd75bebd5 imgt:11145|imgt:isImgtStructureEntryOf|imgt:mAb_952 imgt:Alternative_to_antigen_receptors_(domain_scaffold:_THB_three-helical_bundle)-matraxetan|imgt:construction_detail|Conjugate - Alternative to antigen receptors (domain scaffold: THB, three-helical bundle) - matraxetan imgt:Solid_tumors|imgt:isClinicalIndicationOf|imgt:StudyProduct_61a4c6ee-62ab-3d4d-9a1f-21f03c591c6c imgt:Segment_624_1|imgt:has_rank|1 imgt:StudyProduct_2f224868-e1d3-3d64-af06-4fe62117359e|imgt:hasDecision|_:B538494a9338f7fda23c3f10ec07a735f imgt:Construct_422|imgt:isConstructOf|imgt:IgG1-kappa_422 imgt:Fab%27-G1-nd_139|imgt:radiolabelled_with| Technetium-99m, Tc-99m imgt:StudyProduct_e3ec4548-ebf9-3671-b2a8-b6d058299fab|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:Product_372d02b4-b16a-3ff3-89fa-2a311590437e|imgt:isProducedBy|imgt:Amgen imgt:mAb_387|imgt:inn_proposed_list|105 (2011) imgt:Construct_47|rdf:type|imgt:Construct imgt:Construct_1228|rdf:type|imgt:Construct imgt:CH4-CHS|rdf:type|imgt:C-RegionExonLabel pubmed:8428365|dc:contributor|Tsuchiya M imgt:StudyProduct_2a2fdb31-208f-35fe-9a78-3a56db5bf468|imgt:hasClinicalIndication|imgt:Cancers imgt:Kymab|imgt:produces|imgt:Product_8a1b8bbe-2945-3cb5-b953-e62a4fdd3269 imgt:9825|imgt:isImgtStructureEntryOf|imgt:mAb_549 imgt:Product_4a302c39-2f94-36f4-92b1-fd214b3ec5d3|imgt:commun_name|M777-16-3 imgt:Glenmark_Pharmaceuticals_SA|rdfs:comment|Neuchâtel , Switzerland imgt:StudyProduct_92a1da9e-d7e6-3064-9c53-bae87e962259|imgt:hasClinicalIndication|imgt:Cancers_small_cell_lung_(SCLC) imgt:Product_9644c27e-d6e1-34ac-b2e2-7fc4cdf6bc66|imgt:commun_name|CDP7766 imgt:StudyProduct_3132b9f6-aaad-3395-9967-548169c7bd46|imgt:hasDecision|_:B5ecdb45c3fc7b6bd6906aa8012f0342b imgt:Clone_1153|imgt:clone_name|20C1.009 imgt:StudyProduct_02eab5fa-383c-309d-a7ae-08a64adc9956|imgt:hasClinicalIndication|imgt:Rheumatoid_arthritis_(RA) imgt:StudyProduct_432aca3a-1e34-3e33-9f35-a30c8f65edce|rdf:type|obo:NCIT_C174271 imgt:IgG1-kappa_1023|rdfs:comment|IgG1 - kappa imgt:StudyProduct_4d43e64a-9282-3b26-a0c8-01df3b1cc94e|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_b882302e-e7b4-3e02-a5fe-4d3e86306cf7|imgt:isStudyProductOf|imgt:Product_77251cf3-dc70-36b8-b2f0-5ab289f17bc9 imgt:Product_19e95a60-3bb4-33cc-9dc7-afecc877f175|imgt:isProducedBy|imgt:Xencor_Inc imgt:StudyProduct_f29346f3-33d7-390e-bd59-8bd7be027cfe|rdf:type|obo:NCIT_C174271 imgt:Segment_1223_1|imgt:has_rank|1 imgt:IgG4-nd_676|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG4-nd.png imgt:IgG1-kappa_633|rdf:type|imgt:MAbReceptor imgt:5'D-RS|skos:definition|recombination signal including the 5'D-NONAMER, 5'D-SPACER and 5'D-HEPTAMER of the D-REGION of a D-GENE-UNIT (germline gDNA) (in the 5'UTR), or of the D-REGION of partially-rearranged D-J-GENE (in the 5'UTR), also in D-SEQUENCE (germline cDNA), D-J-SEQUENCE and D-J-C-SEQUENCE (partially-rearranged cDNA) imgt:Segment_1260_2|rdfs:label|Segment_1260_2 imgt:CPCA_%5BPROTEIN_BIG%5D2-FC_395|imgt:hasConstruct|imgt:Construct_395 imgt:StudyProduct_4b230915-2f77-3da9-ad24-3c19c348430f|rdfs:label|StudyProduct_4b230915-2f77-3da9-ad24-3c19c348430f imgt:StudyProduct_a483a0da-bf53-30bd-ba38-62067f933dfe|imgt:hasClinicalPhase|imgt:Phase_I/II imgt:TNF|imgt:isTargetOf|imgt:FPIA_%5BPROTEIN_4REPEATS%5D2-3S-FC_821 imgt:StudyProduct_da7b0ba2-8773-30c0-9a09-cf9dd7a94e71|rdf:type|obo:NCIT_C174271 imgt:Clone_293|obo:RO_0002162|imgt:Homsap imgt:9029|rdf:type|obo:NCIT_C25402 imgt:StudyProduct_30086b40-1961-324c-b4da-8f5853b139be|imgt:hasClinicalIndication|imgt:Glioblastoma imgt:Solid_tumors|imgt:isClinicalIndicationOf|imgt:StudyProduct_58bc3241-029d-32c4-9353-7cccbe997b47 imgt:Product_e055a0d3-71ff-3d4e-ad35-050d316b88bd|imgt:hasStudyProduct|imgt:StudyProduct_ce85069f-44c6-3077-953e-6d7a0efeb14f imgt:IgG1-kappa-4cys-drug_896|rdfs:comment|IgG1 - kappa - 4cys - drug pubmed:14676105|dc:contributor|Yamauchi DM imgt:mAb_52|imgt:inn_name|cantuzumab mertansine imgt:Product_b5954687-d408-39eb-bb39-9453ab30b9a1|imgt:commun_name|MGA017 imgt:Product_b329602e-9fd6-3ee0-a36d-d6f595fa59c9|imgt:hasStudyProduct|imgt:StudyProduct_e4c17257-5255-3824-9770-f3b625812971 imgt:mAb_1178|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=1178 imgt:MS4A1|imgt:isTargetOf|imgt:half-G1-kappa_scFv-HEAVY-LAMBDA-h-CH2-CH3_919 imgt:IgG1-kappa_539|rdfs:comment|IgG1 - kappa imgt:Taizhou_Hanzhong_Pharmaceuticals_Inc|imgt:produces|imgt:Product_abdc580d-8408-3e32-b850-2b01e4fac11e imgt:Multicentric_Castleman's_disease_(MCD)|imgt:isClinicalIndicationOf|imgt:StudyProduct_7e7426bb-4791-35a7-a876-bf20d8f07374 imgt:Product_9dc2e6e7-02dc-385a-9448-66778b7d71e6|imgt:commun_name|UCB-6114 imgt:mAb_278|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=278 imgt:tumour_associated_glycoprotein_72|rdf:type|obo:NCIT_C25702 imgt:_XpressCF+™|imgt:isExpressionSystemOf|imgt:StudyProduct_eb7dc2d9-89c1-3e59-9dd6-bbd47b396981 imgt:Product_db54ace8-9d0d-3afe-8d6e-8dda791a352c|imgt:commun_name|ABP-501 imgt:Product_71c50c60-aeac-3b5e-a928-93a7411e1764|imgt:isProducedBy|imgt:Green_cross_Corp imgt:StudyProduct_161afa13-dadf-397a-9eb9-f764e9e02981|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_d6603759-fe6a-3cb2-bdef-285ef9c6777e|imgt:hasClinicalPhase|imgt:Phase_III imgt:mAb_809|imgt:inn_number|10757 imgt:StudyProduct_87b2fffd-d132-3940-8f56-a6d3acab8395|imgt:hasDecision|_:Bcf99c09ead071dc8557bf8bc53d07c96 imgt:StudyProduct_afef77f5-1ece-3756-9722-4edd208c7552|imgt:hasClinicalPhase|imgt:Phase_II imgt:IgG1-lambda_426|rdf:type|imgt:MAbReceptor imgt:Clone_259|rdfs:label|Clone_259 imgt:AXL|imgt:isTargetOf|imgt:IgG1-kappa_1268 imgt:StudyProduct_ec3380df-8e7d-3c53-a53d-6d97d49448d0|imgt:hasClinicalIndication|imgt:Cancers_colon imgt:mAb_518|imgt:hasMabReceptor|imgt:IgG1-kappa_518 imgt:ENZ_1DOMAIN_782|http://semanticscience.org/resource/SIO_000291|imgt:Factor_substitute imgt:IG-Light-Lambda-IGL|imgt:defines|imgt:IgG2b_Lambda imgt:Segment_1212_1|obo:BFO_0000050|imgt:Construct_1212 imgt:Segment_235_1|rdfs:label|Segment_235_1 imgt:StudyProduct_0088a25d-f5a8-3fa4-ab99-1b5d10e1a87a|rdf:type|obo:NCIT_C174271 imgt:Segment_1151_1|imgt:has_rank|1 imgt:StudyProduct_1d99192d-4b8f-35ef-bd0b-fa72bd86cd18|rdfs:label|StudyProduct_1d99192d-4b8f-35ef-bd0b-fa72bd86cd18 imgt:mAb_1064|imgt:hasProduct|imgt:Product_6082be18-1302-36ab-8a6c-75b884b65d62 imgt:Construct_813|rdfs:label|Construct_813 imgt:StudyProduct_1ab8d4c3-d225-3383-97de-5f1bb986f6f1|imgt:isStudyProductOf|imgt:Product_92aaaa11-a012-35e5-91ee-9df570fa89a7 _:Bf18dd2799dcfc163b8dc67fa2c30e5d4|imgt:hasStatut|imgt:approval imgt:Aspyrian_Therapeutics_Inc|rdfs:label|Aspyrian Therapeutics, Inc. imgt:Construct_1237|imgt:hasImgtLabel|imgt:IgG2-kappa imgt:Product_f4af35da-7830-3280-b962-8cc6e7f4bd35|imgt:isProductOf|imgt:mAb_232 imgt:StudyProduct_fe38caba-b9bf-359c-8993-63e9560277bd|rdf:type|obo:NCIT_C174271 imgt:Product_9988ec5b-fd7a-325e-bd3f-39829a8fc36d|imgt:comercial_name|PERJETA® imgt:StudyProduct_0aca5178-6a90-387a-8990-1deac7a84c73|imgt:development_technology| Dual Variable Domain immunoglobulin (DVD-Ig™) Tetravalent Bispecific Tandem Ig (TBTI) (similar to DVD-Ig™) imgt:mAb_101|imgt:hasMabReceptor|imgt:(scFv-kappa-heavy)-(scFv-heavy-kappa)_101 imgt:mAb_549|imgt:inn_recommended_list|75 (2016) imgt:Construct_892|rdf:type|imgt:Construct imgt:Product_8892de96-5fe3-389f-a136-98d4bfc4724a|rdf:type|obo:NCIT_C51980 imgt:Solid_organ_transplantation|imgt:isClinicalIndicationOf|imgt:StudyProduct_27b295f8-143b-37a3-a8ca-e4f960e36112 imgt:StudyProduct_4b1b67d7-7ffe-3237-9918-a0d5d75d6a28|imgt:application_type|Diagnostic imgt:mAb_129|rdf:type|obo:NCIT_C1909 imgt:F(ab’)2-Gamma-2_Lambda|imgt:isDescribedBy|imgt:F(AB')2-GAMMA-2_LAMBDA imgt:StudyProduct_731e0a81-9e68-35db-b84d-365665c4a62b|imgt:application_type|Therapeutic imgt:Product_48cbaf81-49be-39c7-9cc5-047872a6fdbe|imgt:commun_name|huAnti-B4 imgt:Product_3628c1e7-8007-3900-aa02-fcb45866cf72|imgt:hasStudyProduct|imgt:StudyProduct_78170e97-70c1-3171-ae0d-f8c67e83e3be imgt:IgG2-kappa_248|obo:RO_0002162|imgt:Homsap imgt:mAb_75|imgt:inn_proposed_list|79 (1998) imgt:mAb_1244|rdf:type|imgt:INN _:B44b00ca3ed0e13e7f8e40d6b325745a7|imgt:isDecisionOf|imgt:StudyProduct_946f07c9-d4f0-31e7-93ab-c6d674e08dd4 imgt:11040|imgt:isImgtStructureEntryOf|imgt:mAb_929 imgt:isExpressionSystemOf|owl:inverseOf|imgt:hasExpressionSystem imgt:Segment_41_1|rdfs:label|Segment_41_1 _:B3bfd91be2d04cf2c92280b915b1a9fb9|imgt:hasStatut|imgt:approval imgt:Segment_482_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Construct_413|obo:BFO_0000051|imgt:Segment_413_3 imgt:StudyProduct_6aacda10-a0c5-3a2d-a274-71220827fa67|imgt:hasDecision|_:B1948feff9ddbdce1cf5eaa943c65d1cd imgt:IgG4-kappa_1112|rdfs:label|IgG4-kappa_1112 imgt:TNF|imgt:isTargetOf|imgt:F(ab%27)2-G3-kappa_128 imgt:mAb_284|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=284 imgt:mAb_352|imgt:hasProduct|imgt:Product_dae89c23-6538-30bc-b71e-a66029df4793 imgt:IgG1-nd_46|imgt:hasMolecularComponent|imgt:IG imgt:mAb_1171|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=1171 _:B952c2d4a4ffc64c5f88766f0bf3bea10|imgt:isDecidedBy|imgt:FDA imgt:Product_6de5e4cc-b4a5-392b-a018-f88bb89a8395|rdf:type|obo:NCIT_C51980 imgt:Product_e29ca1a6-d717-32be-8922-7f11c322da77|imgt:commun_name|CR-6261 imgt:SOST|imgt:isTargetOf|imgt:IgG2-lambda_632 imgt:StudyProduct_1436681e-51e4-304c-b3c3-36f7c559c1ee|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:%5BCD4_(p55_T_cell_surface_antigen_T4/Leu-3)-IGHG2_Fusion-CD4_(p55_T_cell_surface_antigen_T4/Leu-3)-IGKC%5D-dimer|rdf:type|imgt:ConstructLabels imgt:mAb_894|rdf:type|obo:NCIT_C136823 imgt:Segment_918_1|imgt:hasImgtLabel|imgt:IgG4-kappa imgt:Construct_303|imgt:hasImgtLabel|imgt:IgG2a-nd imgt:Construct_1061|imgt:isConstructOf|imgt:IgG3-kappa_1061 imgt:IgG1-kappa_143|obo:RO_0002162|imgt:Chi imgt:TR-Alpha_Beta-1|rdf:type|imgt:ReceptorType pubmed:23307031|dc:contributor|Stevens S imgt:mAb_652|imgt:hasOriginClone|imgt:Clone_652 imgt:FPIA_%5BFC-%5BPEPTIDE-PROTEIN%5D2%5D3_998|imgt:hasConstruct|imgt:Construct_998 imgt:Fc-gamma1|rdf:type|imgt:SegmentLabels imgt:Construct_567|obo:BFO_0000051|imgt:Segment_567_1 imgt:mAb_1132|rdf:type|imgt:INN _:B9229d7530317b0720424efa4d0c2597d|imgt:hasDesignation|imgt:Orphan_drug imgt:Construct_408|rdf:type|imgt:Construct imgt:Psoriasis|imgt:isClinicalIndicationOf|imgt:StudyProduct_43484832-71db-3790-b17a-351b54b3d17a imgt:StudyProduct_3e9a72be-3dc1-39fb-b262-537e1e3a30f6|imgt:application_type|Therapeutic imgt:StudyProduct_afef77f5-1ece-3756-9722-4edd208c7552|rdfs:label|StudyProduct_afef77f5-1ece-3756-9722-4edd208c7552 imgt:Product_18666dc9-668e-3abe-bb8e-e14220247d74|imgt:isProducedBy|imgt:Nanjing_Legend_Biotechnology_Co_Ltd _:B0c4fd5beX2D3e5aX2D4dc8X2D8f27X2D2d00f6e3cbe6|rdf:first|imgt:Killer_cell_immunoglobulin-like_receptor imgt:Debiopharm_Internaltional_SA|rdfs:label|Debiopharm Internaltional S.A. imgt:Clone_248|imgt:isOriginCloneOf|imgt:mAb_248 imgt:StudyProduct_ebcac4d8-7f2c-3e2f-8ee7-1464fc760694|imgt:isStudyProductOf|imgt:Product_f5a5b548-f6f0-301d-a830-84a84abe6bed imgt:Product_e25f50c3-9b20-361d-9c46-198fe111366e|rdf:type|obo:NCIT_C51980 imgt:Product_285bd500-f170-3f00-920a-d6ab36e76e9a|imgt:commun_name|iALT-803 (= inbakicept INN 11029 ([IL15RA]2-Fc) in complex 1:2 with nogapendekin alfa INN 11157 (IL15 D72))/i imgt:StudyProduct_4a815db4-c662-3d9e-a584-51db01c7a9fa|imgt:application_type|Therapeutic imgt:Construct_170|imgt:hasImgtLabel|imgt:IgG4-kappa imgt:StudyProduct_1f9cf058-4df4-349c-9eb0-350307f94e31|rdf:type|obo:NCIT_C174271 imgt:mAb_1149|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=1149 imgt:Product_1c81621a-ff42-3937-8f41-30279f630940|imgt:isProductOf|imgt:mAb_223 imgt:Rheumatoid_arthritis_(RA)|imgt:isClinicalIndicationOf|imgt:StudyProduct_db2405b4-3c00-39c2-a8e3-2ad1c51f9e46 imgt:mAb_1101|imgt:inn_proposed_list|123 (2020) imgt:Segment_687_1|rdf:type|imgt:Segment imgt:mAb_746|imgt:clinical_trials|7 studies found, 3 recruiting imgt:StudyProduct_c15bccdd-bf01-38ee-b5a7-5a4e74d5fde2|rdfs:label|StudyProduct_c15bccdd-bf01-38ee-b5a7-5a4e74d5fde2 imgt:mAb_920|imgt:hasMabReceptor|imgt:half-G1-kappa_scFv-HEAVY-LAMBDA-h-CH2-CH3_920 imgt:Product_747d2bfa-44b6-3feb-95ae-81e3134044b6|imgt:commun_name|AK112 imgt:mAb_1248|imgt:inn_proposed_list|126 (2022) imgt:IgG1-kappa_MM_269|imgt:hasMolecularComponent|imgt:IG imgt:Product_7c524e73-547d-3b09-baca-f38148653f91|imgt:commun_name|Syncria imgt:9308|rdfs:label|9308 imgt:MH|rdf:type|imgt:major_histocompatibility imgt:mAb_1233|rdfs:label|mAb_1233 imgt:IgG1-kappa_90|http://semanticscience.org/resource/SIO_000291|imgt:RABV imgt:IgG4-kappa_447|rdfs:label|IgG4-kappa_447 imgt:IgA1_Lambda|imgt:isDescribedBy|imgt:IG-ALPHA-1_LAMBDA imgt:Construct_860|imgt:isConstructOf|imgt:IgG1-kappa_860 imgt:Factor_substitute|skos:definition|Factor substitute imgt:Segment_829_1|imgt:has_rank|1 imgt:Merck_&_Co_Inc|imgt:produces|imgt:Product_01f3c901-db8e-305c-8b01-2789aa0434c1 imgt:mAb_827|imgt:hasProduct|imgt:Product_e74866da-149c-3b1a-b1e9-46e3774546ef imgt:Segment_1140_1|rdf:type|imgt:Segment imgt:IgG4-kappa_1210|rdf:type|imgt:MAbReceptor imgt:mAb_574|imgt:hasImgtStructureEntry|imgt:10175 imgt:StudyProduct_8403651a-4410-3109-8317-334230837d11|imgt:application_type|Therapeutic imgt:Product_68b98f78-23f2-3109-8dac-c2bf17514d02|imgt:isProducedBy|imgt:Tanox_Inc _:Ba4075384108b6f1e37c0b74ee10deb88|imgt:isDecidedBy|imgt:FDA imgt:Schering_AG|imgt:produces|imgt:Product_eb402421-c224-38d4-94cb-61de3b050a04 imgt:Product_e3796ae8-3883-3da0-b6f6-ea37bcf8bcb7|rdf:type|obo:NCIT_C51980 imgt:StudyProduct_d8190ccc-b57c-3021-9c9b-2142ef7f434e|imgt:application_type|Therapeutic imgt:Product_51d4c376-f2c0-341a-bd4d-be7c150e0bcf|rdf:type|obo:NCIT_C51980 imgt:Product_e634066b-75e5-3068-b644-7307d78fe47c|imgt:hasStudyProduct|imgt:StudyProduct_cd465abe-06a6-3a1f-a763-135f99c56841 imgt:EPHA3|rdf:type|obo:NCIT_C25702 imgt:StudyProduct_01c02561-34f0-3864-a55d-2a07cc089cc1|rdfs:label|StudyProduct_01c02561-34f0-3864-a55d-2a07cc089cc1 imgt:StudyProduct_755f95f0-9616-3bfb-8304-7ffd844ae570|imgt:hasClinicalIndication|imgt:Hemophilia_A_(control_and_prevention_of_bleeding_episodes) imgt:Clone_356|rdf:type|obo:NCIT_C37925 imgt:mAb_52|rdf:type|obo:NCIT_C95782 imgt:StudyProduct_9800c448-f4ee-3249-9e9a-fb121a3ddbae|rdfs:label|StudyProduct_9800c448-f4ee-3249-9e9a-fb121a3ddbae imgt:Segment_940_1|obo:BFO_0000050|imgt:Construct_940 imgt:mAb_1215|imgt:hasMabReceptor|imgt:IgG1-kappa_1215 imgt:Product_3b1928d9-c353-3e4e-b423-fe0d01fedf38|rdfs:label|Product_3b1928d9-c353-3e4e-b423-fe0d01fedf38 imgt:Product_39ec5d7e-7e56-320e-81b0-dd2a88a3adf0|imgt:commun_name|IMGN242 imgt:Product_538ab0c9-c52c-3c61-ae4c-1c89532b23a7|imgt:commun_name|4D5-8 imgt:Construct_352|rdf:type|imgt:Construct imgt:CH4D3|rdfs:label|CH4D3 imgt:mAb_873|imgt:inn_recommended_list|81 (2019) imgt:Product_1866c4da-eda3-3d0b-ae71-d676cbace5bc|imgt:isProducedBy|imgt:Centocor_Inc imgt:Genmab_A/S|imgt:produces|imgt:Product_d3b1c87b-c5d7-3da1-8427-6001eddc9b90 imgt:mAb_136|imgt:hasOriginClone|imgt:Clone_136 imgt:Product_fc173cc4-6f3d-3e5b-ad4a-39884eb1c2f8|imgt:commun_name|ASKP1240 _:B633bf1422abb1b2879b4b9c607fbeb92|dc:date|2004-12-17 imgt:Multiple_sclerosis_(MS)|imgt:isClinicalIndicationOf|imgt:StudyProduct_702dbc3d-39c7-30e1-b3b4-1256085457af imgt:StudyProduct_45c712f6-4aba-3516-ae9f-c966ca4b2c6d|imgt:application_type|Therapeutic imgt:IgG2-G4-kappa_674|rdf:type|imgt:MAbReceptor imgt:Segment_1158_2|imgt:hasImgtLabel|imgt:KDR imgt:StudyProduct_07f88f08-8bb3-39d1-8416-508d41a38406|imgt:development_technology| Medarex’s UltiMAb® _:Be5c42d4a6078c77857e28758f69842c3|imgt:isDecisionOf|imgt:StudyProduct_07804ddb-b8d6-31df-9157-36557c4b7b62 imgt:Product_b5ab73f0-6a7d-349a-8fac-132c9549ca1d|imgt:hasStudyProduct|imgt:StudyProduct_b41698f7-655b-3213-bf3f-b0a7d9bc73bd imgt:StudyProduct_b11cc987-484a-309d-9ef0-99725f55a76b|imgt:application_type|Therapeutic imgt:tetravalent|imgt:isTargetOf|imgt:IgG1-kappa-%5BscFv%5D2-lambda_545 pubmed:14676105|dc:contributor|Chu DZ imgt:mAb_195|imgt:hasOriginClone|imgt:Clone_195 imgt:IgG4-kappa-4lys-drug_389|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG4-kappa-4lys-drug.png imgt:mAb_979|imgt:inn_proposed_list|121 (2019) imgt:Product_649c78e1-1746-3b13-9ec9-5bd0cc1a8e70|imgt:isProductOf|imgt:mAb_482 imgt:Construct_893|imgt:hasImgtLabel|imgt:TBP-1_(_tumor_necrosis_factor_(TNF)_binding_protein_variant_1) imgt:toxin|imgt:isTargetOf|imgt:MAbReceptor_511 imgt:anthrax_protective_antigen|imgt:isTargetOf|imgt:IgG1-kappa_549 imgt:Product_13047200-94f7-35ea-a157-8e8bee74ca78|imgt:hasStudyProduct|imgt:StudyProduct_657ccc33-24fa-3743-a75a-6111c145c586 imgt:Clone_1144|imgt:isOriginCloneOf|imgt:mAb_1144 imgt:StudyProduct_fcde6171-1334-344c-8c41-75e1d52240e1|imgt:hasExpressionSystem|imgt:_YB2/0_rat_hybridoma_cells imgt:Cancers_non-small_cell_lung_(NSCLC)|imgt:isClinicalIndicationOf|imgt:StudyProduct_44f02f71-fa31-3d0d-b5d3-9435a6d250ed imgt:Product_e71972eb-fe86-3835-944b-ec9b77978c50|rdfs:label|Product_e71972eb-fe86-3835-944b-ec9b77978c50 imgt:Product_2de293bd-1023-3307-9fbd-5af2cf15c7e6|imgt:hasStudyProduct|imgt:StudyProduct_5add4e94-baa2-309c-b366-ccec806a3556 _:B2ce12e99eb7ae1cc6af52e9fd11aed03|imgt:isDecisionOf|imgt:StudyProduct_98dc1b90-812d-3b2c-a33d-4c5121b2f350 imgt:Segment_305_1|imgt:has_rank|1 pubmed:20035694|imgt:isBibliographicReferenceOf|imgt:mAb_355 imgt:Construct_409|imgt:isConstructOf|imgt:MAbReceptor_409 imgt:Segment_327_1|imgt:has_rank|1 imgt:StudyProduct_e0f17b9d-d2b9-3e09-a385-03d5a433a25d|imgt:application_type|Therapeutic imgt:IgG1-kappa-4cys-drug_531|rdf:type|imgt:MAbReceptor obo:NCIT_C25402|rdf:type|owl:Class imgt:Clone_605|rdf:type|obo:NCIT_C37925 pubmed:1873503|dc:contributor|Matsushita S imgt:ELP_(elastin-like_polypeptide)|rdfs:label|ELP (elastin-like polypeptide) imgt:mAb_675|imgt:inn_proposed_list|120 (2018) imgt:Product_4975e7ab-7850-3795-8d34-6526bce56205|imgt:isProductOf|imgt:mAb_439 imgt:mAb_592|imgt:inn_name|mirvetuximab imgt:Segment_629_1|imgt:hasImgtLabel|imgt:IFNA2 imgt:Segment_838_1|rdfs:label|Segment_838_1 imgt:IgM-nd_310|imgt:hasMolecularComponent|imgt:IG imgt:Segment_870_1|obo:BFO_0000050|imgt:Construct_870 imgt:StudyProduct_ba307e5d-f2be-38ec-97b6-121b9ebf3681|rdfs:label|StudyProduct_ba307e5d-f2be-38ec-97b6-121b9ebf3681 imgt:Product_2cb0cab5-75d3-3ff4-8cf5-4895a2fa5226|imgt:commun_name|anti-hepatitis B imgt:Clone_569|rdf:type|obo:NCIT_C37925 imgt:Clone_148|imgt:clone_name|CHI621 imgt:StudyProduct_1c0bfa05-b077-3781-9c7e-ae7f97c0ef00|imgt:hasClinicalIndication|imgt:Autoimmune_diseases imgt:mAb_458|imgt:inn_number|9714 imgt:Segment_697_2|imgt:hasImgtLabel|imgt:CTP_(C-terminal_peptide_of_the_β-subunit_of_human_chorionic_gonadotropin_(hCG)) imgt:mAb_1293|imgt:inn_proposed_list|126 (2022) _:B5ad7a6ec832e46209737e95c2f2391c4|imgt:hasStatut|imgt:approval imgt:OBI_Pharma_USA_Inc|rdfs:comment|San Diego , USA imgt:MH1-ALPHA|rdfs:label|MH1-ALPHA imgt:mAb_177|imgt:inn_number|11557 imgt:EGFR|imgt:isTargetOf|imgt:IgG1-kappa-4lys-drug_600 imgt:mAb_644|rdf:type|obo:NCIT_C95206 imgt:Product_1a4c8787-fe9d-3f7d-9de8-b2438df5d9b9|imgt:commun_name|REMD-477 imgt:StudyProduct_7e7426bb-4791-35a7-a876-bf20d8f07374|imgt:isStudyProductOf|imgt:Product_c2a35708-7257-3084-8079-8ca3bcca6373 imgt:StudyProduct_3adc6318-e634-3534-9fb2-a10d3048eb2f|imgt:hasDecision|_:Bd08f2014c17517fd730481c1487667f9 imgt:StudyProduct_0a9ebf98-2862-3f47-984d-b0a63bc0d12f|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cellsCOS-7_cells_transient_expression imgt:Segment_413_3|imgt:has_rank|3 imgt:StudyProduct_ebcb3db3-7b55-3b5e-8422-c77a52525bed|imgt:isStudyProductOf|imgt:Product_a22e1e73-39c4-3d58-810c-61a5fe2f2b92 imgt:Clone_135|imgt:isOriginCloneOf|imgt:mAb_135 imgt:StudyProduct_26f816cb-d7cc-3323-8ff2-a13cee4d35ca|rdfs:label|StudyProduct_26f816cb-d7cc-3323-8ff2-a13cee4d35ca imgt:G1-kappa_scFv-h-CH2-CH3_1085|rdfs:comment|G1-kappa_scFv-h-CH2-CH3 imgt:IgA-nd|imgt:construction_detail|IgA - nd imgt:Construct_587|imgt:hasImgtLabel|imgt:IgG4-kappa imgt:Segment_68_1|obo:BFO_0000050|imgt:Construct_68 imgt:IG-Heavy-Gamma-2-IGHG2|imgt:defines|imgt:IgG2_Kappa imgt:Rheumatoid_arthritis_(RA)|imgt:isClinicalIndicationOf|imgt:StudyProduct_3ca16690-952a-38a0-bff4-1f4d35a99ed1 imgt:StudyProduct_7c608379-7a72-3348-bbf8-0b597847afa4|rdfs:label|StudyProduct_7c608379-7a72-3348-bbf8-0b597847afa4 imgt:IgG1-lambda_1011|rdfs:comment|IgG1 - lambda imgt:StudyProduct_95f8f51f-1152-388e-b759-713b64855faf|imgt:hasClinicalIndication|imgt:Multiple_myeloma_(MM) imgt:StudyProduct_de4ef407-46a7-3d97-9488-c7f2d1ac5324|imgt:hasClinicalPhase|imgt:Phase_I/II imgt:VSIR|rdf:type|obo:NCIT_C25702 imgt:half-G1-kappa_scFv-HEAVY-LAMBDA-h-CH2-CH3_921|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/half-G1-kappa_scFv-HEAVY-LAMBDA-h-CH2-CH3.png imgt:Construct_917|imgt:isConstructOf|imgt:PROTEIN_1DOMAIN_917 imgt:IgG4-kappa_898|obo:RO_0002162|imgt:Homsap imgt:mAb_785|rdf:type|obo:NCIT_C166947 imgt:MAbReceptor_62|http://semanticscience.org/resource/SIO_000291|imgt:CEACAM5 imgt:H-GAMMA|rdf:type|imgt:ChainLabels imgt:Product_f8d963eb-e9e0-351e-af1a-29c8b6e0bf58|rdfs:label|Product_f8d963eb-e9e0-351e-af1a-29c8b6e0bf58 imgt:mAb_350|rdf:type|imgt:INN imgt:Novo_Nordisk|imgt:produces|imgt:Product_f15ef329-9b53-3cce-8248-2d74b9f2be45 imgt:StudyProduct_dab25960-187a-3ef7-8541-9922a9f0c26b|imgt:hasClinicalIndication|imgt:Hidradenitis_suppurativa_(HS) imgt:_NS0_mouse_myeloma_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_9cad8c06-7815-3bb8-9d5a-d03c23192156 imgt:Myasthenia_Gravis_(MG)|imgt:isClinicalIndicationOf|imgt:StudyProduct_03a11b7d-d669-3333-9a22-d50c3a66c16b imgt:mAb_1293|imgt:hasImgtStructureEntry|imgt:12029 imgt:CD52|rdf:type|obo:NCIT_C25702 imgt:StudyProduct_7096f391-b9a4-3c65-82a3-94251af99833|rdfs:label|StudyProduct_7096f391-b9a4-3c65-82a3-94251af99833 imgt:StudyProduct_be0b245c-accf-38e1-b355-e2be5c80ea93|rdfs:label|StudyProduct_be0b245c-accf-38e1-b355-e2be5c80ea93 _:Bbe4463cc5a2bf60fe9f7b90961374f13|imgt:hasStatut|imgt:approval imgt:Zoetis|imgt:produces|imgt:Product_69126e38-2f0c-3448-b499-cabc3ca17145 imgt:IgG1-kappa_766|obo:RO_0002162|imgt:Hum imgt:Product_538ab0c9-c52c-3c61-ae4c-1c89532b23a7|imgt:hasStudyProduct|imgt:StudyProduct_2d924b80-9cd2-391c-9954-1ac1206ab109 imgt:Product_f4537a5a-2150-3510-bb0d-59579f1d38f7|rdfs:label|Product_f4537a5a-2150-3510-bb0d-59579f1d38f7 imgt:mAb_713|imgt:hasImgtStructureEntry|imgt:10409 imgt:composite_protein_for_clinical_applications|skos:altLabel|CPCA imgt:StudyProduct_9781db57-fbca-397e-a7b8-253e716a7085|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:IgG1-kappa-4cys-drug_476|imgt:conjugated_with| monomethyl auristatin E (MMAE) imgt:HingeRegionLabel|rdfs:subClassOf|imgt:DomainLabels imgt:StudyProduct_08052363-0619-3302-8aaf-cbb9ae61123b|rdfs:label|StudyProduct_08052363-0619-3302-8aaf-cbb9ae61123b imgt:scFv|rdf:type|imgt:FormatType imgt:Autoimmune_diseases|imgt:isClinicalIndicationOf|imgt:StudyProduct_d76e18ea-00be-3b61-9daa-04b219b160a5 imgt:Construct_967|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:trazimera™|imgt:isBiosimilarOf|imgt:mAb_97 imgt:Centocor_Ortho_Biotech_Inc|imgt:produces|imgt:Product_d7375334-d0db-32f3-81ba-3cfa540a5cf4 imgt:StudyProduct_34263c1d-fc01-3448-bb8c-028a50fab1de|imgt:application_type|Therapeutic imgt:mAb_1130|rdfs:label|mAb_1130 imgt:Segment_869_1|imgt:has_rank|1 imgt:StudyProduct_feb2b884-1e28-3cf6-b19a-b46c52cca30a|imgt:hasClinicalPhase|imgt:Discontinued imgt:mAb_540|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=540 imgt:mAb_976|rdf:type|obo:NCIT_C140041 imgt:mAb_1018|imgt:inn_proposed_list|122 (2019) imgt:CTP_(C-terminal_peptide_of_the_β-subunit_of_human_chorionic_gonadotropin_(hCG))|rdfs:label|CTP (C-terminal peptide of the β-subunit of human chorionic gonadotropin (hCG)) imgt:Product_c25395cf-d8e1-3156-8672-bccded639c93|imgt:commun_name|RO4858696-000 imgt:VSIR|skos:definition|VSIR (V-set immunoregulatory receptor, C10orf54, chromosome 10 open reading frame 54, B7-H5, B7H5, GI24, PD-1H, PDCD1 homolog, SISP1, stress induced secreted protein 1, V-domain Ig suppressor of T cell activation, VISTA) imgt:Segment_720_1|imgt:has_rank|1 imgt:StudyProduct_5fba7f3a-22dc-3bac-a491-e8ae7879345c|imgt:development_technology| MorphoSys's HuCAL® phage library XmAb® Antibody Engineering Technology imgt:mAb_803|imgt:hasMabReceptor|imgt:IgG1-kappa_803 imgt:mAb_557|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=557 imgt:StudyProduct_fe09d174-abe5-3284-9bb6-a413f578ee28|imgt:hasExpressionSystem|imgt:_CHOK1SV_(lacking_the_glutamine_synthetase_(GS)_gene)_cells imgt:Segment_536_1|obo:BFO_0000050|imgt:Construct_536 imgt:Ono_Pharmaceutical_Co_Ltd|rdfs:label|Ono Pharmaceutical Co., Ltd imgt:IgG2-kappa_785|rdf:type|imgt:MAbReceptor imgt:IgG1-kappa-4lys-drug_357|imgt:conjugated_with| maytansinoid DM1 imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_567dca9c-f362-30db-b121-50386b4dbb4b imgt:Canine_T-cell_lymphoma|imgt:isClinicalIndicationOf|imgt:StudyProduct_9198fe52-58d2-3469-ab9e-15ced49c24a2 imgt:Segment_519_1|imgt:has_rank|1 imgt:StudyProduct_40fc9c18-8047-3b09-810d-4e0bc08fe647|rdfs:label|StudyProduct_40fc9c18-8047-3b09-810d-4e0bc08fe647 imgt:mAb_102|imgt:imgt_note| IMGT/DomainGapAlign shows that the V region amino acid sequence of the gevokizumab VH domain is closer to mouse (Mus musculus IGHV8-8*01 (82.8%)) rather to human (Homo sapiens IGHV4-38-2*02 (74.7%)). The H chain is chimeric based on AA sequence analysis. The CH1 domain of 4g6k and 4g6m is from IGHG1*03 whereas it is from IGHG2*02 in gevokizumab. imgt:IgG1-kappa-4lys-drug_602|imgt:conjugated_with| maytansinoid DM1 imgt:StudyProduct_46126144-d789-3994-b8cc-2669cb607f7e|imgt:hasClinicalPhase|imgt:Phase_M imgt:VH-C-kappa-CH2-CH3_V-lambda-CH1_H-GAMMA-1_L-kappa_793|rdfs:comment|VH - C-kappa - CH2 - CH3_V-lambda - CH1_H-GAMMA-1_L-kappa imgt:Segment_155_1|rdfs:label|Segment_155_1 _:Bf51c6c90ca62a19f04404c098fa227eb|rdf:type|obo:NCIT_C53285 imgt:Product_f5e55c8d-239e-36ce-b0ca-d43a9d2f3f03|imgt:isProductOf|imgt:mAb_383 imgt:Product_2521e381-177f-3b68-870d-8cbad0e77285|rdf:type|obo:NCIT_C51980 imgt:Construct_564|imgt:hasImgtLabel|imgt:IgG4-kappa imgt:tetravalent|imgt:isTargetOf|imgt:scFv-h-CH2-CH3_1189 imgt:Clone_224|rdf:type|obo:NCIT_C37925 imgt:Product_2521e381-177f-3b68-870d-8cbad0e77285|imgt:commun_name|BAN2401 imgt:mAb_262|imgt:inn_recommended_list|53 (2005) imgt:MH1-Alpha-MH1-A|rdf:type|imgt:GeneLevelChainType imgt:IgG1-kappa_1018|imgt:hasConstruct|imgt:Construct_1018 imgt:Segment_1291_1|rdf:type|imgt:Segment imgt:Scotgen_Biopharmaceuticals_Ltd|rdf:type|obo:NCIT_C54131 _:Be3c3f917d51b84f91a81e154fa5311e6|imgt:hasStatut|imgt:approval imgt:Construct_548|imgt:isConstructOf|imgt:IgG4-kappa_548 imgt:Rheumatoid_arthritis_(RA)|imgt:isClinicalIndicationOf|imgt:StudyProduct_50c57a82-84df-34c5-bed8-09d115373427 imgt:Product_0650976e-e362-337e-ab9a-2cf669b1c2b0|imgt:hasStudyProduct|imgt:StudyProduct_7f63e836-5b8c-308d-97f6-a77b5d984e21 imgt:Shire_Plc|rdfs:label|Shire Plc imgt:FPIA_%5BPROTEIN_4REPEATS%5D2-FC_245|imgt:isMabReceptorOf|imgt:mAb_245 imgt:PROTEIN_1DOMAIN_1291|imgt:hasConstruct|imgt:Construct_1291 imgt:Product_571363e1-b863-3e4b-852a-36fb1cc4957c|imgt:isProducedBy|imgt:Bayer_HealthCare_Pharmaceuticals imgt:StudyProduct_3905446d-eac2-3d08-aaa1-e60b285c9641|imgt:isStudyProductOf|imgt:Product_7059201d-e2a8-3adc-9d1e-93b8e0e1285d imgt:Segment_1172_1|imgt:hasImgtLabel|imgt:IgG1-lambda2 imgt:Product_c4b957c8-d9b1-392e-a268-028bf9f65d6f|imgt:hasStudyProduct|imgt:StudyProduct_51366621-f546-3023-ab2f-c477c16bd40e imgt:mAb_83|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=83 imgt:mAb_255|rdf:type|obo:NCIT_C48428 imgt:StudyProduct_61a30a33-9767-352a-9a08-87a31caba00d|imgt:application_type|Therapeutic imgt:mAb_520|imgt:hasImgtStructureEntry|imgt:9680 imgt:SELP|imgt:isTargetOf|imgt:IgG2-kappa_667 _:Bf18dd2799dcfc163b8dc67fa2c30e5d4|dc:date|2005-06-01 imgt:mAb_271|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=271 imgt:IgG1-kappa_1280|imgt:hasConstruct|imgt:Construct_1280 imgt:Construct_581|obo:BFO_0000051|imgt:Segment_581_2 imgt:C-DomainLabel|rdfs:subClassOf|imgt:DomainLabels imgt:Product_031662a0-3a4d-355b-86b2-68009454e886|imgt:hasStudyProduct|imgt:StudyProduct_aed540b8-ec0e-3f5d-9751-74a55f126241 imgt:Product_f6eddd34-803e-38c4-988e-4fdccd05fd3b|rdf:type|obo:NCIT_C51980 imgt:Acute_atypical_appendicitis|rdf:type|obo:NCIT_C185637 imgt:reversal_of_the_antiplatelet_effects_of_ticagrelor_(BRILINTA®_a_blood_thinner_platelet_aggregation_inhibitor)|imgt:isClinicalIndicationOf|imgt:StudyProduct_8fa3f462-191c-3a82-aa98-661aad76974e imgt:Construct_1251|imgt:isConstructOf|imgt:IgG1-lambda_1251 imgt:F(ab’)2-Alpha-2_Lambda|imgt:isDefinedBy|imgt:IG-Light-Lambda-IGL imgt:Product_d2501478-25a5-378b-ae83-ee188222f233|rdf:type|obo:NCIT_C51980 imgt:Green_cross_Corp|rdfs:comment|Yongin , South Korea imgt:StudyProduct_27ca3395-6145-312a-adf1-5faad3748746|imgt:isStudyProductOf|imgt:Product_2c266804-4abe-38c4-bb90-bc8a98dd8ad4 imgt:StudyProduct_2e8ffc66-8b75-3c0d-96fa-9ec9d2403912|imgt:application_type|Therapeutic imgt:StudyProduct_5f55bb4c-1cfa-326f-81b0-c75e55a0f285|imgt:isStudyProductOf|imgt:Product_dafd22c1-b296-344b-a18a-fcd81228093f imgt:StudyProduct_e32ab217-37e0-3164-8da0-640b12cede9d|imgt:application_type|Therapeutic imgt:G1-kappa_scFv-h-CH2-CH3_1075|rdfs:comment|G1-kappa_scFv-h-CH2-CH3 imgt:Product_9dffd059-b722-3974-93df-d78b1bdd84a7|rdfs:label|Product_9dffd059-b722-3974-93df-d78b1bdd84a7 imgt:StudyProduct_e5f9bc32-80ee-33ea-9c6d-c28d60583c72|imgt:application_type|Therapeutic imgt:mAb_1054|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=1054 imgt:StudyProduct_26216034-05b3-3a88-9946-c371c77b099c|imgt:hasClinicalPhase|imgt:Phase_II _:B90064bd5c7850a9d5249918ae7b19d48|imgt:hasStatut|imgt:withdrawal imgt:Product_8d65a859-3857-3302-b653-4bc73c441ecb|imgt:isProductOf|imgt:mAb_570 imgt:Segment_716_1|imgt:has_rank|1 imgt:StudyProduct_00ad372a-0d4f-39a5-900f-438420dc71ea|rdfs:label|StudyProduct_00ad372a-0d4f-39a5-900f-438420dc71ea imgt:Construct_809|rdf:type|imgt:Construct _:B10bc87d1e68c38f1db281d50d3e999ab|rdf:type|obo:NCIT_C53285 imgt:IgG2-lambda_944|rdfs:label|IgG2-lambda_944 imgt:Juvenile_Idiopathic_Arthitis_(JIA)_pediatric|imgt:isClinicalIndicationOf|imgt:StudyProduct_5bc6c99c-7bbd-30c2-be5b-542295560075 _:B8af298d91c6f4ed523374d495b83e437|imgt:hasStatut|imgt:approval imgt:StudyProduct_5406aaa7-52cc-37ac-907f-baf766e43a1a|rdf:type|obo:NCIT_C174271 imgt:IgG1-kappa-4cys-drug_1274|rdfs:label|IgG1-kappa-4cys-drug_1274 imgt:mAb_577|rdfs:label|mAb_577 imgt:Product_8f8e07b1-0a56-3f97-8bf0-787b7edf471c|imgt:hasStudyProduct|imgt:StudyProduct_70b9a532-ec91-3494-b50f-e40c7adaae58 imgt:StudyProduct_f435062c-2f5a-3a33-a817-05bebc17e51d|rdfs:label|StudyProduct_f435062c-2f5a-3a33-a817-05bebc17e51d imgt:Product_bfc6d31a-6354-3f4c-a6fa-25c9a6c3dac8|imgt:commun_name|IDEC-152 imgt:StudyProduct_5178c5cc-f29f-305c-9bc4-7f34d28046d4|imgt:application_type|Therapeutic imgt:Construct_609|rdf:type|imgt:Construct imgt:mAb_1021|rdf:type|imgt:INN imgt:Segment_303_1|rdf:type|imgt:Segment imgt:mAb_574|imgt:hasProduct|imgt:Product_0d11bcb8-8209-384d-bad3-07da9a1ee33c imgt:Segment_595_1|rdfs:label|Segment_595_1 imgt:StudyProduct_0d561fbf-1721-35f5-9fe7-1dd27dab9db3|imgt:application_type|Therapeutic 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imgt:StudyProduct_c47859a9-7323-3b02-9b97-441848f91191|imgt:hasClinicalPhase|imgt:Phase_II imgt:Anthera_pharmaceuticals|rdf:type|obo:NCIT_C54131 imgt:StudyProduct_f43e9ef9-e92b-34f3-ba85-ac3eb7e8e36c|imgt:application_type|Therapeutic imgt:PROTEIN_4REPEATS_284|imgt:hasMolecularComponent|imgt:RPI imgt:Product_7bade22b-a6c5-3b9d-9336-099f730a41de|imgt:commun_name|VEGF-trapR1 imgt:isChainOfRes|rdfs:label|isChainOfRes imgt:RemeGen_Ltd|imgt:produces|imgt:Product_13575050-2ff0-3cea-9e48-bb9edfec537d imgt:IgG4-kappa_977|rdfs:label|IgG4-kappa_977 imgt:Product_49c2056b-e4db-3d7e-aeaa-1e329f6571e9|imgt:commun_name|VEGF-trapR1 imgt:Segment_732_2|rdf:type|imgt:Segment imgt:Idiopathic_thrombocytopenic_purpura|rdfs:label|Idiopathic_thrombocytopenic_purpura imgt:Acute_kidney_transplant_rejection|imgt:isClinicalIndicationOf|imgt:StudyProduct_0d5420ee-e3c6-3849-9587-702f367ec256 imgt:IgG1-nd_104|imgt:hasMolecularComponent|imgt:IG imgt:mAb_600|imgt:inn_number|10236 imgt:mAb_291|rdf:type|imgt:INN 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imgt:mAb_740|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=740 imgt:3NFS|rdfs:label|3NFS imgt:StudyProduct_265d14ab-53af-3956-8325-b075a293a498|imgt:hasClinicalIndication|imgt:Acute_myeloid_leukemia_(AML) imgt:Product_39c70977-6744-3fb3-ac1f-33471e65a66e|imgt:isProductOf|imgt:mAb_290 imgt:mAb_414|rdf:type|obo:NCIT_C82359 imgt:TR-BETA-2|imgt:describes|imgt:TR-Beta-2-TRBC2 imgt:Segment_403_1|obo:BFO_0000050|imgt:Construct_403 imgt:MoleculeUnit|rdfs:label|MoleculeUnit imgt:Product_461df871-c57e-3675-a8b8-5adf43f433d2|rdf:type|obo:NCIT_C51980 imgt:Segment_403_1|imgt:has_rank|1 imgt:J-gene|imgt:hasMoleculeUnit|imgt:gene_unit imgt:ALPP|imgt:isTargetOf|imgt:IgG1-nd_45 imgt:StudyProduct_41ce8a41-f9ea-3c5a-a2a4-be7401427736|imgt:hasClinicalPhase|imgt:Phase_II _:Bb817294c8f3cb7162fd660ae2e0b0b2d|imgt:isDecidedBy|imgt:EMA imgt:Product_b9b2acd1-80f6-347f-b121-d8241315bba3|imgt:isProducedBy|imgt:Astellas_Pharma_US_Inc imgt:StudyProduct_7cce0a19-7542-3e6a-817e-a15921eca2f5|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:mAb_829|rdfs:label|mAb_829 imgt:Product_0c5fb596-41fb-3ab4-bbc2-3ab6a19b5b7e|imgt:hasStudyProduct|imgt:StudyProduct_0496c16f-ccc1-3a11-bab5-7c11d4a7c9d8 imgt:Construct_863|rdf:type|imgt:Construct imgt:mAb_721|imgt:hasMabReceptor|imgt:IgG1-kappa-4cys-drug_721 imgt:mAb_73|imgt:imgt_note| Dec 21, 2010, AstraZeneca discontinued development programme on motavizumab for the prevention of RSV and as a result withdrawn its licence application to FDA. However it added that it would continue to develop motavizumab for other treatments of RSV. In 2007, AstraZeneca bought MedImmune created in 1988. On Feb 14, 2019, it was announced that MedImmune will cease to exist as an industry name as the owner AstraZenaca has decided to retire the brand as part of ongoing restructuring efforts.https://www.biopharmadive.com/news/astrazeneca-retires-medimmune-name-amid-sales-turnaround/548489/ imgt:IgG1-kappa-2cys-drug_569|rdfs:comment|IgG1 - kappa - 2cys - drug imgt:mAb_165|imgt:imgt_note| Human antibodies derived from phage display human antibody libraries. HUMIRA® is a registered trademark of AbbVie Inc. AbbVie Inc. is a biopharmaceutical company which results from the separation from Abbott Laboratories (Abbott Park IL USA) in January 2013. The marketing authorisation for TRUDEXA® has been withdrawn by the EMA at the request of the marketing authorisation holder (MAH) Abbott Laboratories on July 26, 2007. 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imgt:IGF2|imgt:isTargetOf|imgt:IgG2-lambda_451 imgt:StudyProduct_f39528a1-ec68-39ee-a847-69451657ce25|imgt:hasExpressionSystem|imgt:_Sp2/0_mouse_hybridoma_cells imgt:Product_9077122f-d92c-3a25-993f-18def51278f5|imgt:commun_name|RG-7221 imgt:IgG1-kappa-1cys_N84.4-drug_1072|rdfs:label|IgG1-kappa-1cys_N84.4-drug_1072 imgt:StudyProduct_8550c843-41ed-3b5a-8e2f-ac30570967bf|imgt:isStudyProductOf|imgt:Product_b874e91f-5c72-30ea-8bd2-f0bf2e6cc591 imgt:Product_b2cc8073-23cf-353d-8ced-550f89677c37|imgt:isProducedBy|imgt:Merck_&_Co_Inc imgt:Segment_1128_1|obo:BFO_0000050|imgt:Construct_1128 imgt:StudyProduct_4778a46d-c73d-3a03-9a1f-5b7d0dabf9c3|imgt:hasClinicalIndication|imgt:Rheumatoid_arthritis_(RA) imgt:scFv-scFv-scFc_lambda_1200|rdfs:comment|scFv-scFv-scFc_lambda imgt:_CHO_(Chinese_Hamster_Ovary)_dihydrofolate_reductase_(DHFR)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_ca5ff5c2-ff07-3d1f-9b95-dfcefd475fbf imgt:FUSION-FLT1-KDR-FGFR1-GAMMA-1|rdf:type|imgt:ChainLabels imgt:StudyProduct_ca66ee28-0fc6-37ba-82aa-15dacaa9a9c3|rdf:type|obo:NCIT_C174271 imgt:Product_d8c15201-2b01-3103-834c-36c50ea739e7|imgt:commun_name|GA201 imgt:Construct_505|imgt:isConstructOf|imgt:IgG1-kappa_505 imgt:Product_d8a5ae73-24a6-3fa8-9ce9-ad6827deda46|imgt:commun_name|RC-28 imgt:Product_2be6bdbd-07af-3c32-a3aa-e83b46fb85bc|imgt:hasStudyProduct|imgt:StudyProduct_8b02da71-802f-32dd-8847-061fc9aea0d2 imgt:TR-Gamma-5_Delta|imgt:isDescribedBy|imgt:TR-GAMMA-5_DELTA imgt:Sarcoma|imgt:isClinicalIndicationOf|imgt:StudyProduct_e9b2e434-2761-38bb-ada7-f973fa546399 imgt:Clone_1066|rdf:type|obo:NCIT_C37925 imgt:Segment_830_3|imgt:has_rank|3 imgt:%5BPEPTIDE-PROTEIN%5D3_818|imgt:isMabReceptorOf|imgt:mAb_818 imgt:StudyProduct_49b9216b-c4b3-320b-a46c-debe10ac306f|rdf:type|obo:NCIT_C174271 obo:NCIT_C174956|rdf:type|owl:Class imgt:Clone_15|imgt:isOriginCloneOf|imgt:mAb_15 imgt:Segment_1269_1|rdf:type|imgt:Segment pubmed:3025856|dc:contributor|Rakowicz-Szulczynska E. imgt:Product_dc5d0295-91f0-3aeb-9b3e-15ed4c4c9f19|imgt:commun_name|AS1402 imgt:IgG1-V-lambda-C-kappa_856|imgt:hasMolecularComponent|imgt:IG imgt:IgG1-lambda_348|rdf:type|imgt:MAbReceptor _:Ba48cf146924d14a875b0813ef1415ed5|rdf:type|obo:NCIT_C53285 imgt:Construct_1222|rdfs:label|Construct_1222 imgt:StudyProduct_c2500a24-a416-3c5d-911b-c5196853f024|imgt:isStudyProductOf|imgt:Product_f67bf612-c97e-3f7e-9be7-c3022bf8d1b1 imgt:scFv-heavy-kappa-scFv-kappa-heavy-CD8A(CO-TM)-TNFRSF9(CY)-CD247_1161|http://semanticscience.org/resource/SIO_000291|imgt:bispecific imgt:mAb_521|rdf:type|obo:NCIT_C171659 imgt:ALB-IFNA2|rdf:type|imgt:CPCALabel imgt:Immunomedics_Inc|imgt:produces|imgt:Product_db8d8267-f336-3715-b038-38454987d7a7 imgt:StudyProduct_c8dad9b0-2c1e-3c06-8d49-121c7f612e1f|imgt:application_type|Therapeutic imgt:mAb_446|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=446 imgt:StudyProduct_683283a5-8ee3-3684-8cd5-82144f28dbc5|rdfs:label|StudyProduct_683283a5-8ee3-3684-8cd5-82144f28dbc5 imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_f9f1975b-f872-369b-b5c9-e8cf58241df8 imgt:Product_571363e1-b863-3e4b-852a-36fb1cc4957c|imgt:commun_name|rIFN-beta-1b imgt:StudyProduct_9b52f642-d4b7-3cc8-93f2-281f15bb283c|rdfs:label|StudyProduct_9b52f642-d4b7-3cc8-93f2-281f15bb283c imgt:11604|imgt:isImgtStructureEntryOf|imgt:mAb_1167 imgt:10524|rdfs:label|10524 imgt:mAb_740|imgt:inn_recommended_list|78 (2017) _:B6d00ad7c640e7f0c45d458241951a824|imgt:isDecidedBy|imgt:FDA imgt:Clone_1286|rdfs:label|Clone_1286 imgt:mAb_372|imgt:hasImgtStructureEntry|imgt:9334 imgt:mAb_234|imgt:inn_name|tigatuzumab imgt:IgG1-kappa_1276|imgt:hasConstruct|imgt:Construct_1276 imgt:Extranodal_NK/T-cell_lymphoma_(ENKTL)|imgt:isClinicalIndicationOf|imgt:StudyProduct_94bed1e7-0c3a-3eb5-9087-72b06c2758dc imgt:Cancers_small_cell_lung_(SCLC)|imgt:isClinicalIndicationOf|imgt:StudyProduct_6f3ded54-f936-3d37-9f9a-66c98aaceb0f 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imgt:IG-Light|rdfs:label|IG-Light imgt:mAb_1040|rdfs:label|mAb_1040 imgt:mAb_242|imgt:inn_number|8448 imgt:10518|rdf:type|obo:NCIT_C25402 imgt:mAb_1114|imgt:imgt_note| WHO Drug Information, Vol. 34, No. 3, 2020. Proposed INN List 124 – COVID-19 (special edition) (9 October 2020) pages 642-669. 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imgt:mAb_336|imgt:inn_recommended_list|63 (2010) imgt:3GKW|rdfs:label|3GKW _:B3ee3fd8f2ed78f37a30b99937e5417f7|rdf:type|obo:NCIT_C53285 imgt:Construct_681|rdf:type|imgt:Construct imgt:Product_9bc66176-d2dc-31b3-aa83-29aeeafd4d04|rdfs:label|Product_9bc66176-d2dc-31b3-aa83-29aeeafd4d04 imgt:Pfizer|imgt:produces|imgt:Product_2715c586-cf44-3ed8-a87b-0d76d5b9bd0c imgt:StudyProduct_02ea65e9-4c4d-37f8-997d-8e64aeddc41b|imgt:hasClinicalIndication|imgt:Celiac_disease imgt:5ID0|rdfs:label|5ID0 imgt:Multiple_myeloma_(MM)|imgt:isClinicalIndicationOf|imgt:StudyProduct_ceb7772c-4230-3f78-9b92-e823888f62fb imgt:IG_Light_Kappa|imgt:defines|imgt:IgM_Kappa_J-chain imgt:StudyProduct_64f62fb8-c9d6-33e3-a84a-a8a9713b02e3|imgt:hasDecision|_:B31d6891c5e1ec320871688b45b299b2a imgt:FN1-8|skos:definition|Fibronectin I imgt:Product_50c4b5c5-024d-321f-b6c3-e7ff39741c4e|rdf:type|obo:NCIT_C51980 _:B2620cb60d40ca83eded43e696c909c45|dc:date|2012-11-08 imgt:C-sequence|imgt:hasConfigurationType|imgt:U 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imgt:Construct_307|obo:BFO_0000051|imgt:Segment_307_1 imgt:Fab-G1-lambda_516|rdf:type|imgt:MAbReceptor imgt:Construct_397|rdf:type|imgt:Construct imgt:StudyProduct_b54c07e4-3115-3aba-903b-306ce102992a|imgt:hasClinicalPhase|imgt:Phase_I imgt:mAb_860|imgt:inn_name|spesolimab imgt:Product_49c2056b-e4db-3d7e-aeaa-1e329f6571e9|imgt:isProducedBy|imgt:Regeneron_Pharmaceuticals_Inc imgt:CD4_(p55_T_cell_surface_antigen_T4/Leu-3)-Pseudomonas_aeruginosa_exotoxin_A|rdf:type|imgt:ConstructLabels imgt:TR-Clan|owl:disjointWith|imgt:IG-Clan imgt:StudyProduct_63df4182-a56c-3791-98cd-3d2446f520ce|imgt:hasClinicalPhase|imgt:Phase_M imgt:mAb_1149|imgt:inn_name|tozorakimab imgt:immature_form|rdfs:label|immature_form imgt:StudyProduct_44a7f8b3-31ac-3651-9776-bce5a4dbd9a9|imgt:hasClinicalIndication|imgt:Inflammatory_diseases imgt:TNFRSF12A|rdf:type|obo:NCIT_C25702 imgt:Product_dbe05b64-0640-322a-811c-7c37fcafe09b|imgt:commun_name|REGN-1979 imgt:Segment_232_1|obo:BFO_0000050|imgt:Construct_232 imgt:Product_48254897-faf9-3351-a974-a0f1aae477e6|imgt:commun_name|MN Immunoconjugate imgt:11453|imgt:isImgtStructureEntryOf|imgt:mAb_1146 imgt:mAb_501|rdfs:label|mAb_501 imgt:FPIA_%5BFC-%5BPEPTIDE-PROTEIN%5D2%5D3_998|imgt:fused_with| Homo sapiens Fc (IG Fragment constant) imgt:Product_1f75d92f-5a63-35f9-ab5f-a481e324ca9f|rdf:type|obo:NCIT_C51980 imgt:FPIA_%5BPROTEIN_1DOMAIN_1CLIKE-PROTEIN_5DOMAINS_5F%5D2-FC_730|rdf:type|imgt:MAbReceptor imgt:IgG1-lambda_189|rdfs:label|IgG1-lambda_189 imgt:mAb_346|rdf:type|obo:NCIT_C1909 imgt:mAb_501|imgt:inn_recommended_list|73 (2015) imgt:mAb_1078|imgt:inn_proposed_list|123 (2020) imgt:INTEGRIN-ALPHA-V_BETA-8|rdfs:label|INTEGRIN-ALPHA-V_BETA-8 imgt:StudyProduct_55e7541c-3eab-3d0c-9193-6cda10fdcba2|imgt:isStudyProductOf|imgt:Product_27c6ab4e-8ce9-3ad2-92b3-945ee20d9e46 imgt:IgG1-kappa_228|http://semanticscience.org/resource/SIO_000291|imgt:IL2RA imgt:B_cell_acute_lymphoblastic_leukemia_(B_cell_ALL)|rdf:type|obo:NCIT_C185637 imgt:Segment_761_1|obo:BFO_0000050|imgt:Construct_761 imgt:mAb_638|imgt:hasProduct|imgt:Product_e055a0d3-71ff-3d4e-ad35-050d316b88bd imgt:IgG1-kappa_1288|rdfs:label|IgG1-kappa_1288 imgt:Segment_878_1|rdfs:label|Segment_878_1 imgt:Construct_231|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:mAb_1103|imgt:hasMabReceptor|imgt:scFv-heavy-kappa-CD8A_(CO-TM)-TNFRSF9_(CY)-CD247_1103 imgt:CRISPR_Therapeutics|imgt:produces|imgt:Product_bba8b2a4-0f05-3650-b850-894d24293147 imgt:Product_d6dfe287-8f31-3b65-86a0-04dab9827141|imgt:hasStudyProduct|imgt:StudyProduct_9801dc10-1bf3-3726-94d1-aaa04acece27 imgt:mAb_671|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=671 imgt:TF|rdf:type|imgt:SegmentLabels imgt:Segment_737_1|imgt:segment_detail|*a (C38) 22-187 imgt:mAb_665|rdfs:label|mAb_665 imgt:MHEngineeredLabel|rdfs:label|MHEngineeredLabel imgt:mAb_411|imgt:clinical_trials|13 studies found, 7 recruiting imgt:9468|rdf:type|obo:NCIT_C25402 imgt:Product_df096a2e-9ca2-34c9-b918-135310033876|imgt:hasStudyProduct|imgt:StudyProduct_f9f1975b-f872-369b-b5c9-e8cf58241df8 pubmed:18081533|dc:date|2008 pubmed:25146490|dc:contributor|Flinn IW imgt:IgG1-kappa_491|rdfs:comment|IgG1 - kappa imgt:mAb_451|rdf:type|imgt:INN imgt:IL21R|rdfs:label|IL21R imgt:StudyProduct_426edf19-0f27-3402-9751-dc7a27c88838|rdfs:label|StudyProduct_426edf19-0f27-3402-9751-dc7a27c88838 imgt:Celgene_corporation|rdfs:label|Celgene corporation imgt:StudyProduct_dece01d9-67ae-3cd7-8c6c-b0a053d1f3e8|rdfs:label|StudyProduct_dece01d9-67ae-3cd7-8c6c-b0a053d1f3e8 imgt:StudyProduct_33876951-f246-3ad5-89f6-0a4499572f85|rdf:type|obo:NCIT_C174271 _:B72c9affccd5d6107a87ce96c04826a8f|imgt:isDecidedBy|imgt:FDA imgt:StudyProduct_856c5397-7756-3d89-9380-256a0d6c6b0f|imgt:isStudyProductOf|imgt:Product_704a95ca-527f-35a5-9876-3e1298544145 imgt:Product_d8ac52a0-51a4-324d-b631-c08568ebae76|imgt:commun_name|LY3832479 imgt:StudyProduct_0b9b180b-365a-3d5d-9ff6-ab0449929fca|rdf:type|obo:NCIT_C174271 imgt:half-IG_G1-kappa/(scFv-heavy-lambda)-h-CH2-CH3|imgt:construction_detail|half-IG G1 - kappa / (scFv - heavy - lambda) -h-CH2-CH3 imgt:mAb_1128|imgt:inn_recommended_list|86 (2021) _:B5c8295b5f9ca49c820eda73b12b9b9a2|imgt:isDecisionOf|imgt:StudyProduct_94bed1e7-0c3a-3eb5-9087-72b06c2758dc imgt:IgG2-kappa_196|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG2-kappa.png imgt:PDL_(Protein_Design_Labs)_BioPharma|imgt:produces|imgt:Product_94ff4548-cf82-3333-b651-af7954d824c6 imgt:StudyProduct_0fe403ef-7b3a-3686-8283-a4cb356a3e53|rdf:type|obo:NCIT_C174271 imgt:mAb_624|imgt:hasProduct|imgt:Product_1cb4c5f8-c327-37cf-bf0a-eeb0c6850a48 imgt:Product_bd27362a-84fc-3955-9a4f-86fb917213bb|imgt:commun_name|FE-301 imgt:Disease-Modifying_Anti-Rheumatic_Drug_(DMARD)|imgt:clinical_domain|Immunology imgt:mAb_1007|imgt:inn_recommended_list|84 (2020) imgt:Segment_1026_1|obo:BFO_0000050|imgt:Construct_1026 imgt:StudyProduct_be8f763d-e2cf-38ad-b706-3f7ae2c239f9|imgt:application_type|Therapeutic imgt:TOXIN_BIG-PROTEIN_825|rdfs:label|TOXIN_BIG-PROTEIN_825 imgt:Product_f164296f-9a73-3f69-b8b0-65757f1c83b3|rdf:type|obo:NCIT_C51980 imgt:Construct_913|rdfs:label|Construct_913 imgt:2F-DOMAIN|rdf:type|imgt:RPILabel imgt:StudyProduct_58b7b6f2-01ed-3e5c-9a8b-b4525a40a200|imgt:hasClinicalPhase|imgt:Phase_M imgt:Product_c0796800-04f9-3ea1-9bd6-c35217a2ca33|rdf:type|obo:NCIT_C51980 imgt:IgG1-kappa_1104|rdf:type|imgt:MAbReceptor imgt:IgG1-kappa-%5BPROTEIN%5D2_914|http://semanticscience.org/resource/SIO_000291|imgt:TFRC imgt:mAb_160|imgt:inn_proposed_list|72 (1994) imgt:IgG1-kappa_350|http://semanticscience.org/resource/SIO_000291|imgt:CD3E imgt:StudyProduct_0b960111-911b-397c-80ea-abee4766eb34|rdf:type|obo:NCIT_C174271 imgt:Clone_645|rdf:type|obo:NCIT_C37925 imgt:StudyProduct_fc17d1f0-b127-3b8d-b372-34a39c1f9265|imgt:isStudyProductOf|imgt:Product_fc173cc4-6f3d-3e5b-ad4a-39884eb1c2f8 imgt:Construct_918|obo:BFO_0000051|imgt:Segment_918_1 imgt:mAb_747|imgt:inn_proposed_list|109 (2013) _:B4d0a78ec806f1311b3995982084e7187|dc:date|2013-06-05 imgt:Product_94b8ef04-33ad-342d-a8f0-5d3313872f31|imgt:hasStudyProduct|imgt:StudyProduct_fb04dcf4-fa40-31d0-b04d-bb8c0ffd8ade imgt:Segment_428_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:mAb_537|rdfs:label|mAb_537 imgt:IGM_Biosciences_Inc|rdf:type|obo:NCIT_C54131 imgt:Severe_acute_respiratory_syndrome_coronavirus_2_(SARS-CoV-2)_infection_(COVID-19)|imgt:isClinicalIndicationOf|imgt:StudyProduct_29e10680-7e7d-30a4-9681-0ec6a25c7fed imgt:StudyProduct_b70513a8-0baa-3a75-ab83-97c07e45443a|imgt:hasClinicalPhase|imgt:Phase_I imgt:mAb_766|imgt:hasMabReceptor|imgt:IgG1-kappa_766 imgt:Product_fb39e6e3-9a4c-3f5e-b00f-d8871ce8bb99|imgt:isProductOf|imgt:mAb_635 imgt:mAb_879|rdf:type|imgt:INN imgt:Zaire_Ebola_virus|imgt:isTargetOf|imgt:IgG1-kappa_726 imgt:CytomX_Therapeutics_Inc|imgt:produces|imgt:Product_9714b306-6ce1-3c30-b822-479b49ca52de imgt:IgG1-nd_93|http://semanticscience.org/resource/SIO_000291|imgt:IGHE imgt:IFNG_(Pr21-161)|rdf:type|imgt:DomainLabel _:Be5bb2f1e542be1a50b627e3a97d3ecaa|imgt:hasStatut|imgt:approval imgt:Product_e74c938c-d5ce-32f7-80c4-b52d9dfc9789|imgt:isProductOf|imgt:mAb_1010 imgt:Product_2c19b4a9-6777-3025-85ff-b23426b8e887|rdfs:label|Product_2c19b4a9-6777-3025-85ff-b23426b8e887 imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_9540c804-8715-398d-a80d-2df6b94b5756 imgt:mAb_1215|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=1215 imgt:Segment_363_1|imgt:has_rank|1 imgt:mAb_1118|imgt:inn_name|nemvaleukin alfa imgt:StudyProduct_74060e28-e11c-3626-96ac-21d736ca7863|imgt:development_technology| Cambridge Antibody Technology (CAT) human antibody phage display library pubmed:1762576|dc:title|Humanization of monoclonal antibodies. imgt:Segment_402_1|imgt:hasImgtLabel|imgt:IgG4-kappa imgt:mAb_134|rdf:type|imgt:INN imgt:VH-VH|rdf:type|imgt:IGEngineeredLabel imgt:mAb_90|imgt:hasImgtStructureEntry|imgt:9053 imgt:Product_b2895cfe-5c84-354a-bccf-c88c0e46a211|rdfs:label|Product_b2895cfe-5c84-354a-bccf-c88c0e46a211 _:Bf8d5b2d966fe4f30a127fa4e47735e32|imgt:isDecidedBy|imgt:FDA imgt:mAb_1114|rdf:type|imgt:INN imgt:Product_d8a5ae73-24a6-3fa8-9ce9-ad6827deda46|imgt:commun_name|VF-Trap-8 imgt:StudyProduct_23f804a5-8d9f-3335-ae08-8239d75c56c9|imgt:isStudyProductOf|imgt:Product_b7bee7b5-34bb-3282-9b4f-2678b12b5b39 obo:NCIT_C1554|rdfs:subClassOf|obo:NCIT_C1909 imgt:Clone_1252|obo:RO_0002162|imgt:Musmus imgt:11710|rdf:type|obo:NCIT_C25402 imgt:Construct_485|imgt:hasImgtLabel|imgt:IgG2-kappa imgt:StudyProduct_132fafe7-9b8f-3d86-8705-46849fb24080|imgt:development_technology| Cambridge Antibody Technology (CAT) human antibody phage display library imgt:FGF19|rdf:type|imgt:SegmentLabels 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imgt:_CHO-S_(Chinese_Hamster_Ovary)_cells_suspension_culture|imgt:isExpressionSystemOf|imgt:StudyProduct_c2507d13-5072-352d-a3f4-c24fbcd25830 imgt:Product_f2202260-1eb1-3ea7-b7bb-a7ab1d7930ea|imgt:commun_name|Anti-PCSK9 imgt:StudyProduct_ebae25c4-1751-3f03-935f-833a3a2334c3|imgt:hasClinicalIndication|imgt:Solid_tumors imgt:StudyProduct_c95dafd3-935a-3760-835a-d841566b1bdc|imgt:isStudyProductOf|imgt:Product_38dcb3a9-d366-365a-80b8-285719fdf525 imgt:Construct_97|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:StudyProduct_8d2cc527-78b9-30c5-a46b-4b4b537a04c2|imgt:application_type|Therapeutic imgt:StudyProduct_dcf8ea96-fca7-3822-8560-6029e8a77add|imgt:hasClinicalIndication|imgt:Multiple_myeloma_(MM) imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_6d44a62a-2492-37df-91b3-c5ae1119d82d imgt:Clone_237|imgt:isOriginCloneOf|imgt:mAb_237 pubmed:1346155|dc:title|Development of humanized bispecific antibodies reactive with cytotoxic lymphocytes and tumor cells overexpressing the HER2 protooncogene. obo:NCIT_C175078|rdfs:subClassOf|obo:NCIT_C1909 imgt:Construct_940|imgt:isConstructOf|imgt:IgG1-kappa_940 imgt:Segment_1283_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:IgG1-kappa_431|imgt:hasConstruct|imgt:Construct_431 imgt:mAb_260|imgt:inn_number|8580 imgt:Product_f4af35da-7830-3280-b962-8cc6e7f4bd35|rdfs:label|Product_f4af35da-7830-3280-b962-8cc6e7f4bd35 imgt:Product_79d778e7-a268-3986-be2c-1751015d118f|rdfs:label|Product_79d778e7-a268-3986-be2c-1751015d118f imgt:StudyProduct_0baedbe6-1604-34c0-94ab-a794447ae333|rdfs:label|StudyProduct_0baedbe6-1604-34c0-94ab-a794447ae333 imgt:StudyProduct_6bcaa017-20d4-3c2e-a4d7-adb692916142|rdfs:label|StudyProduct_6bcaa017-20d4-3c2e-a4d7-adb692916142 imgt:IgG1-kappa_1003|http://semanticscience.org/resource/SIO_000291|imgt:bispecific imgt:StudyProduct_c530d1d3-2c88-3698-a7d7-b829340f11ff|imgt:hasDecision|_:Bc14ac54c22c74bb29088253218119f32 _:B53c7267f9fb06eec9de78d901eb9ca98|imgt:isDecidedBy|imgt:FDA 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and different glycosylation patterns may be differentiated by using a greek letter spelt out in full and added as a second part of a two word name. imgt:StudyProduct_66442d8f-2ea8-3e4e-b7bb-e1dd8b235ba0|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:CD3E|imgt:isTargetOf|imgt:MAbReceptor_996 imgt:Clone_679|rdfs:label|Clone_679 imgt:Cytomegalovirus_(CMV)_infections|rdfs:label|Cytomegalovirus_(CMV)_infections imgt:Construct_791|obo:BFO_0000051|imgt:Segment_791_1 imgt:mAb_704|imgt:hasImgtStructureEntry|imgt:7680 imgt:Hanmi_Pharmaceutical|imgt:produces|imgt:Product_d83f11d1-0413-38d7-9027-724429ec0e9f imgt:StudyProduct_b02fd50f-696c-3bb6-b7c8-73f2fa82adcd|rdfs:label|StudyProduct_b02fd50f-696c-3bb6-b7c8-73f2fa82adcd imgt:Product_ccfd4bb7-d8bd-302b-8b17-e3329a65fcc8|imgt:hasStudyProduct|imgt:StudyProduct_11cf490a-7b79-3dc0-9b81-18af65df2ac5 imgt:Product_cf329a47-6c24-33f5-a9bc-6886fbb8606f|imgt:hasStudyProduct|imgt:StudyProduct_bf0c6988-2641-3c0a-8840-60eccf82f63b imgt:mAb_778|imgt:hasProduct|imgt:Product_e0741335-4875-3e01-a996-dc560274708e imgt:mAb_333|imgt:hasImgtStructureEntry|imgt:9200 imgt:_E.coli_(Escherichia_coli)|imgt:isExpressionSystemOf|imgt:StudyProduct_f194b2c1-54af-36a1-9743-5293ec4e34ae imgt:Diffuse_scleroderma|imgt:isClinicalIndicationOf|imgt:StudyProduct_dfce9127-aae8-3b59-a5aa-7955783ed7ce imgt:Product_befef2c3-f6db-347b-ad59-89c3a928207e|imgt:hasStudyProduct|imgt:StudyProduct_2374f0d0-d23a-3648-8be8-4f44a9fff16c imgt:StudyProduct_f03529af-62ae-377e-9f3a-4dae8ef40574|imgt:hasClinicalPhase|imgt:Phase_III _:B0f5064bb9e544923cfb2fc282a492665|imgt:hasDesignation|imgt:Orphan_drug imgt:Clone_16|imgt:isOriginCloneOf|imgt:mAb_16 imgt:StudyProduct_702dbc3d-39c7-30e1-b3b4-1256085457af|imgt:isStudyProductOf|imgt:Product_892634ba-c82f-36f9-9106-1537e1c79b28 imgt:Construct_1233|imgt:hasImgtLabel|imgt:scFv-kappa-heavy imgt:StudyProduct_e2525ede-6e14-3230-8bb4-d37055d1792e|imgt:hasDecision|_:B2c97b6b35b492232e5d29e8b2823a4d2 imgt:mAb_14|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=14 imgt:Segment_611_2|rdfs:label|Segment_611_2 imgt:StudyProduct_e0acf019-fd3a-31ba-877a-9789cc6dd262|rdfs:label|StudyProduct_e0acf019-fd3a-31ba-877a-9789cc6dd262 imgt:Melanoma_metastatic|imgt:isClinicalIndicationOf|imgt:StudyProduct_df96c908-31f4-3b5e-bc30-3919b5ae18fb imgt:StudyProduct_a63973cd-64cf-32f9-a550-7941312253c6|imgt:isStudyProductOf|imgt:Product_8b260346-f2ee-3675-b1d5-da4ddf2a1424 imgt:Segment_1260_1|imgt:has_rank|1 imgt:IgG1-kappa_1076|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:mAb_410|rdfs:label|mAb_410 imgt:Product_327eb970-adbf-349e-a50e-d9669180ae5d|imgt:commun_name|CX-191 imgt:StudyProduct_e09ced69-a82d-3408-a2f1-7c8527eafb37|imgt:application_type|Therapeutic imgt:IgG1-kappa_327|imgt:isMabReceptorOf|imgt:mAb_327 imgt:Product_1081ab17-8cd8-3029-854d-33096639ce86|rdf:type|obo:NCIT_C51980 imgt:Segment_1051_2|rdf:type|imgt:Segment imgt:VH-VH%27-H-Gamma4-VL-VL%27-C-kappa_794|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/VH-VH'-H-Gamma4-VL-VL'-C-kappa.png _:B531ab3cce7a1d139d6f28312456d7767|imgt:hasStatut|imgt:approval imgt:Segment_736_1|obo:BFO_0000050|imgt:Construct_736 imgt:StudyProduct_5dfe30be-eda1-3639-8dea-4939175ff170|imgt:application_type|Therapeutic imgt:IgG4-kappa_802|obo:RO_0002162|imgt:Chi imgt:Pfizer|imgt:produces|imgt:Product_6fff76bc-baa0-3e3c-9cf8-839e804eb2ac imgt:StudyProduct_40f1808f-c7aa-3636-b5cf-33b05a8e334c|imgt:application_type|Therapeutic imgt:Segment_331_2|imgt:hasImgtLabel|imgt:IGHG1 imgt:IgG1-kappa_367|rdfs:comment|IgG1 - kappa imgt:Boehringer_Ingelheim_Pharmaceuticals|imgt:produces|imgt:Product_178b663d-b922-370c-998e-d8dddfcce38d imgt:StudyProduct_ecd5beb5-126a-3782-9054-61b51ae7c9e5|rdf:type|obo:NCIT_C174271 _:B007c49514bc2a0dfaa3a8b6009e99aee|dc:date|1997-11-01 imgt:StudyProduct_591a07d2-306a-3665-93e9-5761f2d56e3a|imgt:hasExpressionSystem|imgt:_Tobacco_plant_Nicotiana_benthamiana imgt:Thigh|skos:definition| imgt:StudyProduct_78788d97-e061-370c-a2a2-7e4063136dff|imgt:hasClinicalPhase|imgt:Phase_I imgt:Segment_917_1|rdfs:label|Segment_917_1 imgt:IgG1-kappa_576|imgt:isMabReceptorOf|imgt:mAb_576 imgt:Product_3d70c6f7-d58f-3dbd-b8a0-06517209c35b|rdf:type|obo:NCIT_C51980 imgt:VH-TOXIN|skos:definition| imgt:Segment_1156_1|imgt:has_rank|1 imgt:StudyProduct_005d9944-c515-3db3-943a-842810fe9642|imgt:hasClinicalIndication|imgt:Graft-versus-host_disease_(GvHD) imgt:Product_a7b373c0-f329-3b03-b24e-41f48c77a159|imgt:isProductOf|imgt:mAb_490 imgt:eticovo™|rdfs:comment| ETICOVO™ (etanercept-ykro) developed by Samsung Bioepis (Incheon Korea) approved by FDA on April 25 2019. Same clinical indications as ENBREL®. Label PDF imgt:CEACAM5|imgt:isTargetOf|imgt:IgG1-kappa-6cys-drug_558 imgt:Construct_1287|rdf:type|imgt:Construct imgt:StudyProduct_09df3e91-f429-3b15-9a77-4979462fba4c|imgt:hasDecision|_:Bff9ce4f3d845c804e5b869006beba563 imgt:Product_5dde1122-ca49-3ad6-8e30-d28049e1461d|imgt:hasStudyProduct|imgt:StudyProduct_a19c7e6d-dacb-3962-ad32-ab8dfbf103b1 imgt:IG-GAMMA-1_V-KAPPA-C-LAMBDA|skos:definition|IG comprising the VH-CH1 domains from a H-GAMMA-1 chain and a V-LAMBDA-C-KAPPA chain imgt:Product_c2a35708-7257-3084-8079-8ca3bcca6373|imgt:isProducedBy|imgt:Centocor_Inc imgt:Segment_486_1|obo:BFO_0000050|imgt:Construct_486 imgt:Clone_29|rdfs:label|Clone_29 imgt:IgG4-nd_279|http://semanticscience.org/resource/SIO_000291|imgt:IL5 imgt:StudyProduct_14463583-eb30-3e6b-b17d-75f1022568ed|rdf:type|obo:NCIT_C174271 imgt:Product_17437870-8a85-360e-9eed-33f6073c5608|rdfs:label|Product_17437870-8a85-360e-9eed-33f6073c5608 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- heavy - lambda) -h-CH2-CH3 imgt:Fab-Gamma-2-c_Kappa|rdf:type|imgt:ReceptorType obo:NCIT_C111999|rdfs:subClassOf|obo:NCIT_C1909 imgt:NovImmmune|imgt:produces|imgt:Product_90c8d5c4-a75e-3484-8230-3404f25c120c imgt:Weill_Cornell_Medical|imgt:produces|imgt:Product_8a665ccb-3040-3133-a43c-0685bb662383 imgt:mAb_242|imgt:centerwatch_link|http://www.centerwatch.com/drug-information/fda-approvals/drug-details.aspx?DrugID=985 imgt:IgG1-kappa_677|imgt:hasConstruct|imgt:Construct_677 imgt:mAb_399|rdfs:label|mAb_399 imgt:V-J-C-CLUSTER|owl:sameAs|obo:SO_0000535 imgt:EGFR|imgt:isTargetOf|imgt:IgG1-kappa_76 imgt:Product_f1256184-14be-352c-97bb-4a84a7bea8e0|rdfs:label|Product_f1256184-14be-352c-97bb-4a84a7bea8e0 imgt:Segment_992_1|obo:BFO_0000050|imgt:Construct_992 imgt:mAb_1126|imgt:inn_recommended_list|86 (2021) imgt:StudyProduct_1908904b-3f05-3853-9f4f-c1111838685d|imgt:hasClinicalPhase|imgt:Phase_III imgt:Construct_186|rdf:type|imgt:Construct imgt:StudyProduct_5e71b1dd-9ab2-3249-a5d9-508cd9d5ced1|rdfs:label|StudyProduct_5e71b1dd-9ab2-3249-a5d9-508cd9d5ced1 imgt:StudyProduct_241f0c88-e88f-38db-81c1-28e1f54cfcbb|imgt:application_type|Therapeutic imgt:Product_5021057f-cae7-3bd7-9a40-1a3c99bf3ca5|imgt:commun_name|OTSA101-DTPA obo:NCIT_C156141|rdfs:subClassOf|obo:NCIT_C1909 imgt:StudyProduct_58bc3241-029d-32c4-9353-7cccbe997b47|imgt:hasClinicalPhase|imgt:Phase_I imgt:IL15|imgt:isTargetOf|imgt:IgG1-kappa_177 imgt:mAb_825|imgt:inn_number|10770 imgt:mAb_761|rdf:type|imgt:INN imgt:Construct_1130|rdf:type|imgt:Construct imgt:StudyProduct_cad06487-fba8-32fe-ac47-aae7c63a6693|imgt:hasClinicalIndication|imgt:Lupus_nephritis imgt:StudyProduct_fdbfed3e-6d3c-31a1-ab0c-e84a3891fa36|imgt:application_type|Therapeutic imgt:_CHO_(Chinese_Hamster_Ovary)_MTX_(methotrexate_resistant)_cells|rdfs:label| CHO (Chinese Hamster Ovary) MTX (methotrexate resistant) cells imgt:Segment_518_1|rdfs:label|Segment_518_1 obo:NCIT_C152261|rdfs:subClassOf|obo:NCIT_C1909 imgt:ACVR2A|rdf:type|obo:NCIT_C25702 imgt:Product_eaa50595-7c42-33fb-a33a-988a28daf176|imgt:commun_name|tanibirumab imgt:Diabetic_macular_edema|imgt:isClinicalIndicationOf|imgt:StudyProduct_988f16a7-b509-3d22-868d-d5da13250685 imgt:Product_58a491b5-79db-3fa2-b693-4ba518a8dcac|imgt:commun_name|Ha15-10ac.1vcMMAE imgt:FUSION-IL2-GAMMA-1|rdfs:label|FUSION-IL2-GAMMA-1 imgt:Product_df7aa59a-c953-3d7c-aae2-38c9ce0095f4|imgt:hasStudyProduct|imgt:StudyProduct_e0f17b9d-d2b9-3e09-a385-03d5a433a25d imgt:IgG1-kappa_1078|imgt:hasMolecularComponent|imgt:IG https://doi.org/10.1038/321522a0|dc:contributor|Neuberger M.S. imgt:mAb_503|rdf:type|obo:NCIT_C125608 imgt:StudyProduct_566e6ad9-5efa-33fa-b243-1f4df11a0f83|imgt:hasClinicalIndication|imgt:Multiple_sclerosis_(MS) imgt:10518|imgt:isImgtStructureEntryOf|imgt:mAb_827 imgt:StudyProduct_82aae299-6df2-32b3-996d-a4992380a4e2|imgt:application_type|Therapeutic imgt:StudyProduct_1ff5ecf2-e3c9-3646-9248-69820495c22f|imgt:hasDecision|_:Bf5497b162f109b6b3e707dedc13351ae imgt:10933|rdf:type|obo:NCIT_C25402 imgt:StudyProduct_6c4310e8-5853-3fa6-aeb2-9abd5f0abf91|imgt:hasClinicalIndication|imgt:Type_2_diabetes_(T2_DM) imgt:Segment_778_1|rdf:type|imgt:Segment imgt:APP|imgt:isTargetOf|imgt:IgG2-kappa_369 imgt:Segment_1048_1|obo:BFO_0000050|imgt:Construct_1048 imgt:Construct_1118|obo:BFO_0000051|imgt:Segment_1118_1 imgt:Clone_859|rdfs:label|Clone_859 imgt:StudyProduct_48474ed3-d570-312e-a6fb-683e3913eea7|imgt:hasClinicalIndication|imgt:Multiple_myeloma_(MM) imgt:StudyProduct_fc5cc4ff-cd79-3360-ba2c-9cb8a2518a23|rdfs:label|StudyProduct_fc5cc4ff-cd79-3360-ba2c-9cb8a2518a23 imgt:Construct_904|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Amgen|imgt:produces|imgt:Product_2dc565df-2fcf-3fe3-9975-3a850426b48a imgt:_CHO_(Chinese_Hamster_Ovary)_glutamine_synthetase_(GS)_deficient_cells_|rdf:type|imgt:ExpressionSystem imgt:Segment_333_1|rdf:type|imgt:Segment imgt:Product_1b66cd8f-973f-324a-9af1-29e3f46d766e|imgt:hasStudyProduct|imgt:StudyProduct_895bacc3-02a9-3f50-8df3-055219a4f520 imgt:mAb_1256|rdfs:label|mAb_1256 imgt:digoxin|skos:definition|digoxin imgt:RPI-MH1Like|imgt:isDescribedBy|imgt:MH1LIKE-ALPHA imgt:Segment_4_1|imgt:has_rank|1 _:B6886783945eae3db669739626afc4c70|rdf:type|obo:NCIT_C53285 imgt:StudyProduct_dc8e8832-a548-38c5-9bec-3f5f63c1ea11|imgt:isStudyProductOf|imgt:Product_161faa12-b0ac-3430-b158-48f495203162 pubmed:8302875|dc:date|1994 imgt:Colitis_ulcerative_(UC)_pediatric|imgt:isClinicalIndicationOf|imgt:StudyProduct_b9c1c916-5714-3827-9cc3-e400f7b2e42c imgt:FC-ALPHA|rdf:type|imgt:StructureLabels imgt:CPCA_PEPTIDE-PEG-FC_830|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/CPCA_PEPTIDE-PEG-FC.png imgt:Segment_26_1|rdfs:label|Segment_26_1 imgt:StudyProduct_d08001fe-9bd8-377d-b56d-2cffd39b2bdd|imgt:application_type|Therapeutic imgt:TR-Subgroup|rdfs:subClassOf|imgt:Subgroup imgt:_E.coli_(Escherichia_coli)|imgt:isExpressionSystemOf|imgt:StudyProduct_82fd7c74-ea4a-3e37-ba9a-116be9109767 imgt:StudyProduct_7c032185-923e-30f0-809b-77357355d8de|rdfs:label|StudyProduct_7c032185-923e-30f0-809b-77357355d8de imgt:Product_0dc35379-efa3-32cf-93ef-6c88dcbb0baf|imgt:commun_name|ALG-991 imgt:StudyProduct_32d70ad9-f8d2-39b5-89d8-a879ed7a2880|imgt:hasDecision|_:Bab4256bc642422224222047650fc306d imgt:Segment_568_1|imgt:has_rank|1 imgt:mAb_249|imgt:centerwatch_link|http://www.centerwatch.com/drug-information/fda-approvals/drug-details.aspx?DrugID=1104 imgt:mAb_54|imgt:hasBibliographicReference|https://doi.org/10.1038/321522a0 imgt:Melanoma|imgt:isClinicalIndicationOf|imgt:StudyProduct_40ffcbf7-63af-365e-b8de-1fef7954cc01 imgt:CPCA_PROTEIN_3REPEATS-PEPTIDE-MYRISTOYL_264|rdfs:comment|CPCA_PROTEIN_3REPEATS-PEPTIDE-MYRISTOYL imgt:DomainLabel|rdfs:subClassOf|imgt:DomainLabels imgt:StudyProduct_88292b86-7a14-37c5-9681-001550cab8be|imgt:hasClinicalIndication|imgt:Diabetic_macular_edema imgt:mAb_1092|imgt:inn_proposed_list|123 (2020) imgt:Clone_971|rdf:type|obo:NCIT_C37925 imgt:StudyProduct_8d7975cb-13e4-34b9-80f4-71a0cba59723|rdfs:label|StudyProduct_8d7975cb-13e4-34b9-80f4-71a0cba59723 imgt:IG-Locus|owl:disjointWith|imgt:MH-Locus imgt:StudyProduct_19cc6408-f0aa-3834-ad48-f94c100cab33|rdfs:label|StudyProduct_19cc6408-f0aa-3834-ad48-f94c100cab33 _:B0f5064bb9e544923cfb2fc282a492665|imgt:isDecisionOf|imgt:StudyProduct_28790f9e-30be-3e9c-b827-69ba060ccb1e imgt:StudyProduct_d234256b-ab49-3a01-95d9-b79cd3fb3168|imgt:hasDecision|_:B5ad7a6ec832e46209737e95c2f2391c4 imgt:Product_36cb4986-4d03-31c7-b2d0-954c198844be|imgt:isProducedBy|imgt:Janssen_Biotech_Inc imgt:IgG4-kappa_1112|http://semanticscience.org/resource/SIO_000291|imgt:ANGPT2 imgt:Construct_324|rdf:type|imgt:Construct imgt:Product_d3b1c87b-c5d7-3da1-8427-6001eddc9b90|imgt:hasStudyProduct|imgt:StudyProduct_62b47614-c15e-3d58-853f-5748943ec9d8 imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_6a59b155-d8b1-35ec-952e-799b7e86acb1 imgt:IgG1-kappa_360|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:Product_1a2d7afe-fb0d-33fe-9798-879a917f9548|rdf:type|obo:NCIT_C51980 imgt:Construct_212|obo:BFO_0000051|imgt:Segment_212_2 imgt:Segment_392_2|imgt:hasImgtLabel|imgt:IGHG1 imgt:Wnt_ligands|rdfs:label|Wnt ligands _:B9a63d6004a6633e417e3d5b8dac7970e|dc:date|2018-08-08 imgt:StudyProduct_d13463ab-484e-3b47-821a-63605119d127|imgt:hasClinicalIndication|imgt:Stroke imgt:Product_36cb4986-4d03-31c7-b2d0-954c198844be|rdf:type|obo:NCIT_C51980 imgt:StudyProduct_19fc649f-7083-3cef-91d4-f00a7feb01af|imgt:hasClinicalIndication|imgt:Hepatocellular_carcinoma_(HCC) imgt:mAb_1153|imgt:inn_proposed_list|124 (2020) imgt:Solid_tumors|imgt:isClinicalIndicationOf|imgt:StudyProduct_ba5846bc-9689-3122-b3c1-045007a7f673 imgt:IgG2a-kappa_132|rdf:type|imgt:MAbReceptor imgt:11198|rdf:type|obo:NCIT_C25402 imgt:IG-Heavy-Alpha-1-IGHA1|rdf:type|imgt:GeneLevelChainType imgt:StudyProduct_e9b87722-0d14-35a4-a37e-fbe53bca414e|imgt:isStudyProductOf|imgt:Product_04ac483d-3770-31ee-be76-21b370f3667d imgt:StudyProduct_96603d21-ce18-3f87-9d06-4acc1b685b08|imgt:isStudyProductOf|imgt:Product_dfe835ee-5c5b-301c-9664-637ed6a8128c imgt:IgG1-kappa_660|rdfs:comment|IgG1 - kappa imgt:StudyProduct_c75294a2-ea9c-39c5-945a-77fcbfc9098c|imgt:development_technology| Abgenix's XenoMouse® imgt:mAb_673|imgt:inn_number|9580 imgt:Segment_701_2|rdf:type|imgt:Segment imgt:Product_97984f90-666b-3255-b4ca-53dfa6fe9b05|imgt:hasStudyProduct|imgt:StudyProduct_9411466a-7875-375d-97bd-cd5c967040d3 imgt:mAb_584|imgt:inn_number|9916 imgt:FC-GAMMA-2A|skos:definition|Fc comprising the CH2-CH3 domains from two H-GAMMA-2A chains imgt:Product_eea47d07-89ad-3942-ae9e-4016eb771f1a|imgt:hasStudyProduct|imgt:StudyProduct_0d5420ee-e3c6-3849-9587-702f367ec256 imgt:mAb_1206|imgt:hasImgtStructureEntry|imgt:11843 imgt:mAb_419|imgt:hasProduct|imgt:Product_73d7ad4c-b6ea-323f-9ed4-f75c83e0c600 imgt:StudyProduct_f2c33795-07dd-383e-98dc-a816a4d6062f|rdfs:label|StudyProduct_f2c33795-07dd-383e-98dc-a816a4d6062f imgt:StudyProduct_d99b48a5-f6e6-3f2c-86fc-22b10b5e48c4|rdf:type|obo:NCIT_C174271 imgt:IgG1-kappa_518|rdfs:comment|IgG1 - kappa imgt:Construct_563|imgt:isConstructOf|imgt:IgG4-kappa_563 imgt:Cytomegalovirus_(CMV)_infections|rdf:type|obo:NCIT_C185637 imgt:Product_12be981a-d52d-3197-b2a3-b970642e0c79|imgt:isProductOf|imgt:mAb_1128 imgt:IgG1-kappa_362|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:_Sp2/0_mouse_hybridoma_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_005d9944-c515-3db3-943a-842810fe9642 imgt:mAb_470|imgt:imgt_note| June 13, 2014. Oncomed’s voluntary clinical trial halt enrollment and dosing of vantictumab and ipafricept following reports of mild-to-moderate bone marrow adverse events. July 1, 2014: FDA partial clinical hold following the company's voluntary halt. August 28, 2014: FDA removal of the partial clinical hold. imgt:StudyProduct_1a95c6e9-fbfd-3aa5-8b53-495de00d8b5d|imgt:hasClinicalIndication|imgt:Pemphigus_vulgaris_(PV) imgt:Controlled_Ovarian_Stimulation_(COS)|imgt:isClinicalIndicationOf|imgt:StudyProduct_465c65e8-2298-32e9-bc34-8aaabb00e18f _:Bf70d41281fdbc18fe9ab7b1f1e7f9ff1|imgt:hasStatut|imgt:approval imgt:IgG1-lambda_852|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-lambda.png _:Bbc746d2f081c1f71625b6b973d70f9cc|rdf:type|obo:NCIT_C53285 imgt:Fab-G2a-kappa_124|http://semanticscience.org/resource/SIO_000291|imgt:myosin,_cardiac imgt:V-J-gene|protege:protege#subclassesDisjoint|true imgt:mAb_639|imgt:hasProduct|imgt:Product_bb920c26-88f7-3605-b3b5-e5f956005067 imgt:Product_30bb3825-e8f6-31cc-a075-c0f87bb4978c|rdfs:label|Product_30bb3825-e8f6-31cc-a075-c0f87bb4978c imgt:IgG1-kappa_300|rdfs:label|IgG1-kappa_300 imgt:10383|rdfs:label|10383 imgt:Inflammatory_bowel_disease_(IBD)|imgt:clinical_domain|Immunology imgt:Product_bebc2f14-8f71-3ea6-8a19-cbba5d49a3c8|rdfs:label|Product_bebc2f14-8f71-3ea6-8a19-cbba5d49a3c8 imgt:Product_dfd76734-a3be-35b1-b724-1e2a258ffacd|imgt:commun_name|SRK-015 imgt:mAb_998|imgt:hasMabReceptor|imgt:FPIA_%5BFC-%5BPEPTIDE-PROTEIN%5D2%5D3_998 imgt:IgG2a-nd_109|rdf:type|imgt:MAbReceptor imgt:Product_9f61d0dc-ba14-3734-8ebb-dff0831d7b1a|imgt:hasStudyProduct|imgt:StudyProduct_0b2dd449-a8d5-3155-b6ea-d97309491c6a imgt:mAb_776|imgt:hasImgtStructureEntry|imgt:10656 imgt:StudyProduct_ebcac4d8-7f2c-3e2f-8ee7-1464fc760694|rdfs:label|StudyProduct_ebcac4d8-7f2c-3e2f-8ee7-1464fc760694 imgt:StudyProduct_f5b5f2b6-8fd7-38b9-938b-4f838a392b75|imgt:hasClinicalPhase|imgt:Phase_M imgt:mAb_157|imgt:hasMabReceptor|imgt:IgG1-lambda_157 imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_7cce0a19-7542-3e6a-817e-a15921eca2f5 imgt:CONJUGATE-(Oxyntomodulin_analog_PEG_linker)_-FC-GAMMA-4|rdf:type|imgt:ChainLabels imgt:Alexion_Pharmaceuticals_Inc|rdfs:label|Alexion Pharmaceuticals Inc. imgt:Segment_1151_1|rdfs:label|Segment_1151_1 imgt:TGFB1|skos:definition|TGFB1 (transforming growth factor beta1, TGF beta) _:B90e0dc5974ac68125854df06f2d6e772|rdf:type|obo:NCIT_C53285 imgt:F(AB')2-ALPHA_KAPPA|rdf:type|imgt:StructureLabels imgt:11954|rdfs:label|11954 imgt:StudyProduct_25d572e2-3633-3829-b477-3a66deb30420|imgt:hasClinicalPhase|imgt:Phase_I imgt:MAbReceptor_202|imgt:isMabReceptorOf|imgt:mAb_202 imgt:10277|rdfs:label|10277 imgt:Growth_hormone_(GH)_deficiency_pediatric|rdfs:label|Growth_hormone_(GH)_deficiency_pediatric imgt:StudyProduct_cad06487-fba8-32fe-ac47-aae7c63a6693|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_be510659-5251-3a3c-b846-8a22c519d6d6|imgt:hasDecision|_:B4cbdc2ccc46682942a66bb86df38810a _:B5a82b6eb68ddc792acae8bf12cc9966e|dc:date|2000-05-17 obo:NCIT_C134697|rdfs:subClassOf|obo:NCIT_C1909 imgt:IgM-nd_191|imgt:hasConstruct|imgt:Construct_191 obo:NCIT_C170281|rdfs:subClassOf|obo:NCIT_C1909 imgt:IL15|skos:definition|IL15 (interleukin 15, IL-15) imgt:mAb_139|imgt:inn_number|7519 imgt:is_defined_by|dc:identifier|imgt_000109 imgt:Canine_B-cell_lymphoma|imgt:isClinicalIndicationOf|imgt:StudyProduct_b499475d-1ffb-3506-b588-4b1369c49104 imgt:StudyProduct_505c50fd-582b-39f6-a814-3ba9cee5db61|rdf:type|obo:NCIT_C174271 imgt:F|rdfs:label|Functional imgt:Segment_119_1|rdf:type|imgt:Segment imgt:IgM-kappa_129|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgM-kappa.png obo:NCIT_C174727|rdf:type|owl:Class imgt:Product_a9dc8357-d2fb-326b-8112-94c3a050705d|imgt:isProductOf|imgt:mAb_1045 imgt:Cytogen_Corp|rdf:type|obo:NCIT_C54131 imgt:mAb_281|imgt:hasProduct|imgt:Product_e3796ae8-3883-3da0-b6f6-ea37bcf8bcb7 _:B30727169319a3efd28b5addc528962e4|imgt:isDecisionOf|imgt:StudyProduct_0485cef8-ac82-346b-aa36-ae9f4bdb7da9 imgt:Segment_507_1|obo:BFO_0000050|imgt:Construct_507 imgt:Autoimmune_diseases|imgt:isClinicalIndicationOf|imgt:StudyProduct_f06e7a18-a561-3e84-bf9c-ed6f94641b1f imgt:mAb_346|imgt:imgt_note| previously developed by CuraGen Corporation (Branford CT USA) imgt:Product_ed1e8186-4f31-37d5-85c3-9b5b8b1a524f|rdf:type|obo:NCIT_C51980 imgt:StudyProduct_ea79bddf-0faf-384d-97e2-e6a5b3d491d6|imgt:hasClinicalPhase|imgt:Phase_M imgt:Construct_428|rdfs:label|Construct_428 imgt:Product_10043700-1e80-3056-8d74-e66e9f904bbf|imgt:isProductOf|imgt:mAb_208 imgt:Segment_814_1|obo:BFO_0000050|imgt:Construct_814 imgt:Segment_351_1|imgt:has_rank|1 imgt:FUSION-(Oxyntomodulin_analog_PEG_linker)_-FC-GAMMA-4|rdf:type|imgt:ChainLabels imgt:mAb_1154|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=1154 imgt:StudyProduct_47845097-3a00-3b73-9d59-751c4db6a7ee|rdf:type|obo:NCIT_C174271 imgt:ROR1|rdfs:label|ROR1 imgt:mAb_667|rdf:type|imgt:INN imgt:Product_7ce2f7b8-fb77-36e0-89f8-7a6d2aa437ac|imgt:commun_name|inebilizumab-cdon imgt:mAb_96|imgt:atc_link|http://www.whocc.no/atc_ddd_index/?code=L04AC07 imgt:Segment_429_1|rdf:type|imgt:Segment imgt:10664|rdfs:label|10664 imgt:StudyProduct_132fafe7-9b8f-3d86-8705-46849fb24080|imgt:hasDecision|_:B1f9064a8a40f017c8da5b4e23906b3de imgt:produces|rdfs:range|obo:NCIT_C51980 imgt:_Saccharomyces_cerevisiae|imgt:isExpressionSystemOf|imgt:StudyProduct_60dfa53b-3345-3e41-ac21-3e5522a41ada imgt:mAb_55|imgt:hasBibliographicReference|pubmed:2451287 imgt:StudyProduct_39a07acf-358e-3f3a-825b-9ea75267ff72|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_d434aff9-6703-3bb9-bf7d-2b8c4392570a|imgt:application_type|Therapeutic imgt:Segment_581_3|rdfs:label|Segment_581_3 imgt:Segment_409_1|obo:BFO_0000050|imgt:Construct_409 imgt:Construct_1108|rdfs:label|Construct_1108 imgt:StudyProduct_e06ffe39-2f35-3f04-be74-5419cd3e8cbb|imgt:application_type|Therapeutic imgt:10820|rdfs:label|10820 imgt:StudyProduct_7b3742d7-bcb4-3f36-a556-e5759a2f156f|rdfs:label|StudyProduct_7b3742d7-bcb4-3f36-a556-e5759a2f156f imgt:mAb_1033|imgt:inn_proposed_list|122 (2019) pubmed:14676105|dc:contributor|Shibata S imgt:Clone_105|obo:RO_0002162|imgt:Ratsp. imgt:IgG1-kappa_234|http://semanticscience.org/resource/SIO_000291|imgt:TNFRSF10B imgt:StudyProduct_0b960111-911b-397c-80ea-abee4766eb34|imgt:application_type|Therapeutic imgt:Clone_151|imgt:isOriginCloneOf|imgt:mAb_151 imgt:Product_e70ba7eb-94b9-348c-8b18-b66d7bca828b|imgt:isProducedBy|imgt:OBI_Pharma_USA_Inc imgt:StudyProduct_d17f568c-2f95-3814-9c7b-159fefc500e3|imgt:hasClinicalPhase|imgt:Phase_II imgt:MAbReceptor_317|rdf:type|imgt:MAbReceptor https://doi.org/10.1371/journal.pmed.0030237|imgt:isBibliographicReferenceOf|imgt:mAb_439 imgt:IgG1-kappa_661|imgt:isMabReceptorOf|imgt:mAb_661 imgt:8824|imgt:isImgtStructureEntryOf|imgt:mAb_396 imgt:IgG4-kappa_1131|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG4-kappa.png imgt:StudyProduct_4a9f9692-20ef-39ea-8fed-211ffb4c6e6a|rdfs:label|StudyProduct_4a9f9692-20ef-39ea-8fed-211ffb4c6e6a imgt:Biogen_Inc|rdfs:comment|Cambridge , USA imgt:MedImmune|rdfs:comment|Gaithersburg , USA _:B28d4baf838f42478db517f659bb86b48|imgt:isDecidedBy|imgt:FDA imgt:StudyProduct_f076d291-a18a-317a-9d91-2653f3cde677|imgt:development_technology| Medarex’s UltiMAb® imgt:MH2|rdfs:label|MH2 imgt:StudyProduct_5182aa24-c119-3cff-b150-a7a40e3bf4f9|imgt:isStudyProductOf|imgt:Product_6a18513a-d0e4-37c5-80b2-122a63ee4ba2 imgt:StudyProduct_28790f9e-30be-3e9c-b827-69ba060ccb1e|imgt:hasClinicalIndication|imgt:Solid_organ_transplantation imgt:StudyProduct_508a95bf-5d28-3d49-be16-322407c6ed14|rdfs:label|StudyProduct_508a95bf-5d28-3d49-be16-322407c6ed14 imgt:StudyProduct_8a84372d-24b7-33d8-9f94-7a6a1fe6782b|imgt:application_type|Therapeutic 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imgt:StudyProduct_58f8aee9-c2f0-36d7-87a8-70b094eb6267|imgt:isStudyProductOf|imgt:Product_8e058ff0-4725-306f-82b2-de22387d53af imgt:IgG1-kappa_90|rdfs:label|IgG1-kappa_90 imgt:IgG4-kappa_1017|http://semanticscience.org/resource/SIO_000291|imgt:LAG3 _:B99555052f58c2ede402ed013a3d49f9b|rdf:type|obo:NCIT_C53285 imgt:mAb_246|imgt:inn_recommended_list|60 (2008) imgt:Construct_949|imgt:hasImgtLabel|imgt:Ig(G1-kappa_G1-lambda) imgt:Product_69aca6bd-b362-373e-98be-9f1735773595|imgt:hasStudyProduct|imgt:StudyProduct_b184eb22-771a-392e-9d61-6646f94d32ca imgt:Product_4fca6fa6-19ec-3b75-967c-377d6768e2ef|imgt:hasStudyProduct|imgt:StudyProduct_dc72fa34-486c-3e9d-a321-65ce6cbb02ef imgt:Product_d8f8f32a-4a56-3077-910a-bd55a9d0cae3|imgt:isProducedBy|imgt:Gilead imgt:StudyProduct_52c977a0-d7e8-34e4-94d4-a8442f8eb205|imgt:hasClinicalIndication|imgt:Mesothelioma_pleural_malignant imgt:StudyProduct_6a3cd9f0-59b0-3a03-8c62-c9b42238c140|imgt:hasExpressionSystem|imgt:_CHO-K1 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imgt:mAb_1176|imgt:hasImgtStructureEntry|imgt:11699 imgt:Adenocarcinoma|rdfs:label|Adenocarcinoma imgt:FUSION-TNFSF18-GAMMA-1|skos:definition|TNFSF18 fused with G1 H-CH2-CH3 imgt:FUSION-malE-MPZ|rdfs:label|FUSION-malE-MPZ pubmed:648586|dc:contributor|Bright LD imgt:StudyProduct_7c032185-923e-30f0-809b-77357355d8de|imgt:isStudyProductOf|imgt:Product_cc1f4c5e-16f9-3c1a-81a2-ad837c23f5bb imgt:mAb_1200|imgt:inn_proposed_list|125 (2021) _:B5ebf0da577c90c199924e89ce1cdbe2f|rdf:type|obo:NCIT_C53285 imgt:Product_9bc66176-d2dc-31b3-aa83-29aeeafd4d04|imgt:commun_name|antidote for dabigatran imgt:Segment_14_1|rdfs:label|Segment_14_1 imgt:mAb_82|imgt:hasProduct|imgt:Product_cb1dc7ce-b8b2-385d-93aa-ad7f2c2311af imgt:IL2RG|rdfs:label|IL2RG obo:NCIT_C125549|rdf:type|owl:Class imgt:Segment_706_1|imgt:segment_detail|1-39 peptidylpenta-L-lysyl-L-lysinamide imgt:mAb_142|imgt:imgt_note| mAb radiolabelled used in radio-immuno-scintigraphy Withdrawal of approval of the indication for treatment of patients with relapsed or refractory, low grade, follicular, or transformed CD20 positive Non-Hodgkin's lymphoma who have not received prior rituximab; BEXXAR® (Press release ). imgt:StudyProduct_624f84ca-f52b-3a1c-8c31-9d3e5868f307|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:Construct_866|obo:BFO_0000051|imgt:Segment_866_1 imgt:Clone_186|obo:RO_0002162|imgt:Homsap imgt:StudyProduct_e189c556-df4c-3e83-8fbb-71a91cb759a8|imgt:hasDecision|_:B9845a1d968d3496af6a6aa322c4c0bdf imgt:mAb_279|imgt:hasBibliographicReference|pubmed:8844835 imgt:Construct_844|obo:BFO_0000051|imgt:Segment_844_1 imgt:IgG1-kappa_1005|rdf:type|imgt:MAbReceptor imgt:StudyProduct_5d929fb9-1a83-3c1b-9d53-25c8414a39bb|rdfs:label|StudyProduct_5d929fb9-1a83-3c1b-9d53-25c8414a39bb imgt:Construct_566|rdf:type|imgt:Construct imgt:Kidney_transplantation_treatment_of_antibody-mediated_rejection_(AMR)|imgt:isClinicalIndicationOf|imgt:StudyProduct_5073cae6-7c07-3b27-b9f0-0d169d9b8328 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imgt:StudyProduct_fe6a6dcb-b974-3272-b7e1-eba9e336f6d2|imgt:isStudyProductOf|imgt:Product_589c62e2-46ec-3016-ac0f-8ee0131ebfaf imgt:Human_Genome_Sciences|rdf:type|obo:NCIT_C54131 obo:NCIT_C156705|rdfs:subClassOf|obo:NCIT_C1909 imgt:Product_770e5549-b827-3967-8e0a-db64781042be|imgt:hasStudyProduct|imgt:StudyProduct_8d8de119-afe2-3a45-bc9e-7cc917c3df93 imgt:PROTEIN_1DOMAIN-PEG_625|rdf:type|imgt:MAbReceptor imgt:(scFv-kappa-heavy)-h-CH3|imgt:construction_detail|(scFv - kappa - heavy) -h- CH3 imgt:Cancers|imgt:isClinicalIndicationOf|imgt:StudyProduct_3b49444b-27d5-3009-9948-320cd9518ba7 imgt:Product_2c97ff1c-8864-35a5-9400-a09ca0516e0d|imgt:isProductOf|imgt:mAb_227 imgt:mAb_1108|imgt:inn_number|11863 imgt:Cancers_esophageal|rdf:type|obo:NCIT_C185637 imgt:10737|imgt:isImgtStructureEntryOf|imgt:mAb_802 imgt:StudyProduct_07dfb1be-7cba-3419-a233-465efef5c44d|imgt:application_type|Therapeutic imgt:mAb_1007|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=1007 imgt:mAb_696|imgt:inn_recommended_list|42 (1999) imgt:di-Fab%27|rdfs:label|di - Fab' _:B239266280859919ce082ee111695a609|imgt:isDecidedBy|imgt:FDA imgt:mAb_544|imgt:hasMabReceptor|imgt:IgG1-kappa_544 imgt:Clone_274|rdfs:label|Clone_274 imgt:Product_472580a9-a9b7-36d2-8b15-c38c1bd71e1f|imgt:hasStudyProduct|imgt:StudyProduct_a67a0c59-7b7f-38d1-aa09-7b70854fe345 imgt:isDecisionOf|rdfs:label|isDecisionOf imgt:J-sequence|protege:protege#subclassesDisjoint|true imgt:StudyProduct_5f6ba3f1-6121-376f-9726-4f0554e86b62|rdfs:label|StudyProduct_5f6ba3f1-6121-376f-9726-4f0554e86b62 imgt:Construct_1214|rdf:type|imgt:Construct imgt:MAbReceptor_833|imgt:hasMolecularComponent|imgt:IG imgt:Inflammatory_conditions|imgt:isClinicalIndicationOf|imgt:StudyProduct_9be1aca9-e335-3957-b164-170056af884c imgt:StudyProduct_d056838d-1c33-3a44-80ed-6217d85daf28|rdfs:label|StudyProduct_d056838d-1c33-3a44-80ed-6217d85daf28 imgt:mAb_1091|rdf:type|obo:NCIT_C175793 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Proposed INN List 124 – COVID-19 (special edition) (9 October 2020) pages 642-669. Proposed INN List 124 (19 December 2020, published on 22 January 2021) pages 929-1102. 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imgt:Clone_967|rdf:type|obo:NCIT_C37925 imgt:Construct_1239|rdfs:label|Construct_1239 imgt:StudyProduct_939b3314-6b35-370e-aadb-30c09a6e28f6|rdfs:label|StudyProduct_939b3314-6b35-370e-aadb-30c09a6e28f6 imgt:Product_20fcba1e-a0bb-3838-8745-6c6f5da541f2|rdf:type|obo:NCIT_C51980 imgt:StudyProduct_bf101d12-c918-343a-af15-691a79ed2bb6|rdfs:label|StudyProduct_bf101d12-c918-343a-af15-691a79ed2bb6 imgt:IgG1-kappa_812|http://semanticscience.org/resource/SIO_000291|imgt:CD3E imgt:IgG1-kappa_860|obo:RO_0002162|imgt:Chi imgt:StudyProduct_d4930ea7-e483-3038-bacf-0735e7e036b9|imgt:application_type|Therapeutic imgt:StudyProduct_ba0c4175-6d0a-3397-888e-10055e790391|imgt:application_type|Therapeutic imgt:StudyProduct_63a86089-810a-39d9-ae53-715878b51594|imgt:hasClinicalIndication|imgt:Adenocarcinoma_gastric imgt:IgG1-kappa-S239C_2cys-drug_904|rdfs:label|IgG1-kappa-S239C_2cys-drug_904 imgt:mAb_1037|rdfs:label|mAb_1037 imgt:Platelet_aggregation|rdf:type|obo:NCIT_C185637 imgt:StudyProduct_692b60e6-af48-3d91-b20f-8d02fdda6b57|imgt:application_type|Therapeutic imgt:11611|imgt:isImgtStructureEntryOf|imgt:mAb_1122 imgt:V-INTRON|skos:definition|noncoding sequence of an IG or TR between L-PART1 and V-EXON, in gDNA or in unspliced cDNA obo:NCIT_C170054|rdfs:subClassOf|obo:NCIT_C1909 imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_4ae01645-c1e9-38af-86e6-d49652281689 imgt:Clone_234|rdf:type|obo:NCIT_C37925 imgt:Segment_615_1|imgt:hasImgtLabel|imgt:PDCD1LG2 imgt:Product_40fd3b5d-f917-3fed-97f6-62ec12bc834e|imgt:isProductOf|imgt:mAb_541 imgt:mAb_731|imgt:clinical_trials|13 studies found, 6 recruiting imgt:IgG2a-lambda_142|imgt:radiolabelled_with| Iodine-131, I-131 imgt:_Hybridoma_murine_ascites|imgt:isExpressionSystemOf|imgt:StudyProduct_85cd4d9f-8bd0-3880-8a9c-3d163d5e1644 imgt:IgG1-kappa_740|obo:RO_0002162|imgt:Hum imgt:StudyProduct_8fe16f6f-1d15-3ebd-a29a-5600ea1fef34|imgt:hasClinicalPhase|imgt:Phase_M imgt:mAb_1105|rdfs:label|mAb_1105 imgt:IgG1-lambda_852|imgt:hasConstruct|imgt:Construct_852 imgt:Product_2b62ff3b-5777-30b1-8021-af790e255f4e|imgt:hasStudyProduct|imgt:StudyProduct_4784e7fe-8ef2-3b5d-82a9-2a04b89fe5ff imgt:9940|rdf:type|obo:NCIT_C25402 imgt:Infertility|imgt:isClinicalIndicationOf|imgt:StudyProduct_a87c7ab7-0aba-3c60-b0ce-34686ba730c0 imgt:StudyProduct_026b75f7-c995-3045-a2f6-daa0a331f298|imgt:hasClinicalIndication|imgt:Solid_tumors imgt:Product_55aa2dba-a058-31a7-91b8-376994712cb7|imgt:isProductOf|imgt:mAb_1102 imgt:hasMabReceptor|rdf:type|owl:ObjectProperty _:B89b5de6e03d0106adffe658117018ba6|imgt:hasStatut|imgt:approval imgt:IgG1-kappa_1024|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:mAb_802|imgt:imgt_note| True North Therapeutics, Inc was bought by Bioverativ, Inc. in June, 2017. See publication imgt:isPrototypeOf|rdf:type|owl:ObjectProperty imgt:Product_c49fe1bd-70e4-3192-91d0-1125b060119b|imgt:commun_name|MEDI-507 imgt:11581|rdfs:label|11581 imgt:Product_537aaf49-2c7a-3981-8bd7-5b72ab2e0fb9|imgt:isProducedBy|imgt:Roche_F_Hoffmann-La_Roche_Ltd imgt:StudyProduct_81102e8a-33d7-3b67-9d03-c9113452c687|imgt:isStudyProductOf|imgt:Product_4bf3114f-4cbf-347a-af9a-2e7f19e6991f imgt:StudyProduct_ef0fc8d7-fd61-3b8a-a8e0-a1f2e5bc4431|imgt:hasClinicalPhase|imgt:Phase_I imgt:Product_79efa394-2362-32e1-a324-34d6c5fe9313|rdf:type|obo:NCIT_C51980 imgt:Product_37ffad37-3840-3cfc-a777-f523c62fcb62|imgt:commun_name|GEN-1042 imgt:Product_d8f8f32a-4a56-3077-910a-bd55a9d0cae3|imgt:hasStudyProduct|imgt:StudyProduct_7260d7d2-b3b5-3029-b88b-e6c4988593c0 pubmed:1905261|rdf:type|bibo:Article imgt:Segment_2_1|rdfs:label|Segment_2_1 imgt:Product_f36504b9-7a54-3056-b3e8-26781525dfe1|rdfs:label|Product_f36504b9-7a54-3056-b3e8-26781525dfe1 imgt:StudyProduct_f076d291-a18a-317a-9d91-2653f3cde677|rdfs:label|StudyProduct_f076d291-a18a-317a-9d91-2653f3cde677 imgt:Canine_parvovirus|imgt:isClinicalIndicationOf|imgt:StudyProduct_f06ddced-f629-3fe1-8214-39aeb5883f40 imgt:mAb_102|imgt:inn_recommended_list|66 (2011) imgt:mAb_543|imgt:hasMabReceptor|imgt:MAbReceptor_543 imgt:mAb_802|imgt:inn_recommended_list|80 (2018) imgt:StudyProduct_3e8e545e-eddd-3e3f-8a98-e684875993b4|imgt:hasClinicalIndication|imgt:Autoimmune_diseases imgt:mAb_38|imgt:inn_recommended_list|47 (2002) imgt:mAb_130|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=130 obo:NCIT_C170350|rdfs:subClassOf|obo:NCIT_C1909 imgt:mAb_199|rdf:type|obo:NCIT_C2066 imgt:mAb_811|imgt:hasMabReceptor|imgt:IgG1-lambda_811 imgt:Construct_660|rdf:type|imgt:Construct imgt:Construct_1132|rdfs:label|Construct_1132 imgt:StudyProduct_6e9abc4c-f770-366f-bfcb-7d494780f0d8|imgt:hasDecision|_:Be0db5e1772a0edcab25821901ed53c51 imgt:Product_9ebf016b-a406-3b46-a794-766df093076c|rdf:type|obo:NCIT_C51980 imgt:StudyProduct_037a290c-5cd1-3f09-b298-2d6e639875bc|rdf:type|obo:NCIT_C174271 imgt:Segment_959_1|imgt:has_rank|1 imgt:IG-GAMMA-2-4_KAPPA|rdf:type|imgt:IGEngineeredLabel imgt:mAb_311|imgt:hasMabReceptor|imgt:IgG1-nd_311 imgt:PROTEIN_1DOMAIN_683|rdfs:comment|PROTEIN_1DOMAIN imgt:mAb_647|imgt:hasImgtStructureEntry|imgt:10301 imgt:mAb_115|imgt:inn_number|7201 imgt:mAb_536|imgt:hasMabReceptor|imgt:scFv-kappa-heavy_536 imgt:Construct_1111|rdf:type|imgt:Construct imgt:StudyProduct_ba9e9204-abc8-3172-8a91-386bfbb5abb7|rdfs:label|StudyProduct_ba9e9204-abc8-3172-8a91-386bfbb5abb7 imgt:Segment_445_1|imgt:has_rank|1 imgt:IgG2-lambda_664|obo:RO_0002162|imgt:Homsap imgt:Segment_697_2|obo:BFO_0000050|imgt:Construct_697 imgt:Product_338fcdb6-423f-3b44-a92f-0d5476cec2df|rdf:type|obo:NCIT_C51980 imgt:Product_3a189900-85ec-39fd-961e-db4cc48bbcb2|imgt:isProductOf|imgt:mAb_1245 imgt:Construct_999|rdfs:label|Construct_999 imgt:StudyProduct_e32138e4-4d52-3d17-ac1c-1ded34267982|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_8fafb39d-a882-31f1-80c7-29f8cbf3627b|imgt:hasDecision|_:Bfaad2e7c1461d7a240c704c9bb4ee582 imgt:9710|imgt:isImgtStructureEntryOf|imgt:mAb_455 pubmed:21091110|rdfs:label|PMID_21091110 imgt:V-D-REGION|rdf:type|imgt:ComposedRegionLabel imgt:StudyProduct_ea189e94-52bf-3ada-9202-208f164eaee5|imgt:application_type|Therapeutic imgt:mAb_227|imgt:imgt_note| Biogen (Cambridge MA USA) and IDEC Pharmaceuticals (San Diego USA CA) merged in 2003 creating Biogen Idec. Biogen Idec has changed its name to Biogen (23 March 2015). Genentech Inc. is a member of Roche Group since March 26, 2009. imgt:StudyProduct_ad122ef9-3131-34d2-a14b-4ed64d51c069|rdf:type|obo:NCIT_C174271 imgt:Segment_358_1|rdfs:label|Segment_358_1 imgt:StudyProduct_ad148a23-483e-36c3-a08d-6918c97fabc6|imgt:hasClinicalIndication|imgt:Systemic_lupus_erythematosus_(SLE) imgt:MAbReceptor_751|imgt:hasConstruct|imgt:Construct_751 imgt:mAb_966|imgt:hasImgtStructureEntry|imgt:10940 imgt:IgG1-nd_68|imgt:hasMolecularComponent|imgt:IG _:Bb361c75360909c8d70e95248a223b73e|imgt:isDecisionOf|imgt:StudyProduct_1bb5231d-7bbf-380d-8760-5bc506b4667c imgt:Product_63e4e4b4-5918-3eef-818c-291c25f73777|imgt:isProductOf|imgt:mAb_255 imgt:StudyProduct_4782b1c1-f2ea-311e-ba07-ac9afd5f009b|rdf:type|obo:NCIT_C174271 obo:NCIT_C174771|rdfs:subClassOf|obo:NCIT_C1909 imgt:Planet_Biotechnology|rdfs:comment|Hayward , USA imgt:StudyProduct_5a6137d4-60d5-3de5-934c-96a3a1bbbd70|rdfs:label|StudyProduct_5a6137d4-60d5-3de5-934c-96a3a1bbbd70 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imgt:mAb_289|imgt:inn_name|alvircept sudotox imgt:StudyProduct_325e5cda-6137-3a4e-80fe-43c7609968e4|imgt:hasClinicalPhase|imgt:Phase_M imgt:StudyProduct_141c27b7-1f12-324c-9e37-98bea60711bf|rdf:type|obo:NCIT_C174271 imgt:Product_bfb4b102-cf74-3ddd-b981-5824b1904091|imgt:isProducedBy|imgt:Genentech_Inc imgt:StudyProduct_895bacc3-02a9-3f50-8df3-055219a4f520|imgt:application_type|Therapeutic imgt:IgG1-lambda_323|obo:RO_0002162|imgt:Homsap imgt:Segment_24_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:StudyProduct_b5bb588b-b379-31c3-9058-a22e42f60488|imgt:hasClinicalIndication|imgt:Cancers_bladder imgt:StudyProduct_2b7f353a-d8aa-3509-b95e-9945de9a63ae|imgt:hasClinicalIndication|imgt:Autoimmune_diseases obo:NCIT_C175073|rdfs:subClassOf|obo:NCIT_C1909 imgt:FPIA_%5BPROTEIN-PROTEIN-PROTEIN-PROTEIN%5D2-FC_1158|imgt:hasMolecularComponent|imgt:FPIA imgt:StudyProduct_880048e4-140b-39df-8cc2-288ca967d860|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:StudyProduct_4b3ccea3-961f-3102-9e9c-20f015542dfe|imgt:application_type|Therapeutic imgt:mAb_850|imgt:hasOriginClone|imgt:Clone_850 imgt:LEO_pharma|rdf:type|obo:NCIT_C54131 imgt:IgG1-kappa-2cys-CH3-1_1284|imgt:hasConstruct|imgt:Construct_1284 imgt:Construct_875|imgt:isConstructOf|imgt:IgG1-kappa_875 imgt:Product_dafd1d43-d4e4-3d41-aea8-181641c8acbd|rdfs:label|Product_dafd1d43-d4e4-3d41-aea8-181641c8acbd imgt:mAb_1152|imgt:inn_proposed_list|124 (2020) imgt:mAb_1174|imgt:inn_recommended_list|87 (2022) imgt:StudyProduct_fcde6171-1334-344c-8c41-75e1d52240e1|rdf:type|obo:NCIT_C174271 imgt:IgG4-kappa_1021|imgt:isMabReceptorOf|imgt:mAb_1021 imgt:StudyProduct_c385cdfb-64b4-3173-a9ec-4b1c36083e42|imgt:isStudyProductOf|imgt:Product_85bf09db-dcaa-3c16-83c2-0e68aaabd997 imgt:StudyProduct_e543e8e8-b123-3318-b436-d583a18ef879|imgt:hasClinicalPhase|imgt:Phase_I imgt:Product_6c67e17c-42f8-38c2-9f6f-6580bc4cf2e7|imgt:isProductOf|imgt:mAb_662 imgt:Clone_1253|rdf:type|obo:NCIT_C37925 imgt:Product_46d67bc6-e981-393e-b1cb-7109846d0174|imgt:hasStudyProduct|imgt:StudyProduct_5e4bd1ba-5aaf-3593-8928-ee78cc13f6bb imgt:IgG2-lambda_470|rdfs:comment|IgG2 - lambda imgt:IgG1-kappa-4F-drug_1259|imgt:conjugated_with| debotansine imgt:StudyProduct_4cb665ec-b73c-3c97-a281-597114c2b2dc|imgt:hasClinicalIndication|imgt:Renal_cell_carcinoma_(RCC) imgt:Clone_128|rdfs:label|Clone_128 imgt:IgG1-kappa_454|imgt:isMabReceptorOf|imgt:mAb_454 imgt:IL4|imgt:isTargetOf|imgt:IgG1-kappa_88 imgt:Celiac_disease|imgt:isClinicalIndicationOf|imgt:StudyProduct_d80656d3-6574-3674-9d8d-460d84f0d743 imgt:Solid_tumors|imgt:isClinicalIndicationOf|imgt:StudyProduct_bb3f95c6-4b3d-35c9-ba6e-13fe3700b5fa obo:SO_0000539|rdf:type|owl:Class imgt:Segment_52_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:StudyProduct_6a51865b-a2bb-3a85-9e96-4a425b1806c1|imgt:application_type|Therapeutic imgt:Xencor_Inc|rdf:type|obo:NCIT_C54131 imgt:Product_557d6f3c-8aa3-35e6-bb7d-6df5196f42e8|imgt:isProducedBy|imgt:Pfizer imgt:mAb_436|imgt:hasProduct|imgt:Product_27f3c39d-c940-36e9-b77b-b5638fb484c9 imgt:StudyProduct_5bdaac6d-ba9c-3f18-bdc9-82c9ce089909|imgt:development_technology| Abgenix's XenoMouse® _:Bbe2a3440a9ba62ac28d059c0075d7090|imgt:isDecisionOf|imgt:StudyProduct_8bc896ef-ddc2-370c-bd39-256effff24e0 imgt:StudyProduct_26216034-05b3-3a88-9946-c371c77b099c|imgt:isStudyProductOf|imgt:Product_02550586-7a1b-3018-bf60-0ad7c06c9f86 imgt:Product_f0221536-d202-3194-8a6c-80a5b460de1b|imgt:commun_name|BART imgt:Anemia_associated_with_end_stage_renal_disease|imgt:isClinicalIndicationOf|imgt:StudyProduct_03b7ff0f-2d1f-3a11-b8bd-d1b049ee566b imgt:StudyProduct_4a15ef37-c104-3c66-be53-61f0924d6fb2|rdf:type|obo:NCIT_C174271 imgt:mAb_1177|imgt:inn_name|ivicentamab _:B5ecdb45c3fc7b6bd6906aa8012f0342b|imgt:hasDesignation|imgt:Orphan_drug imgt:Construct_1224|obo:BFO_0000051|imgt:Segment_1224_1 imgt:Segment_1141_1|rdf:type|imgt:Segment imgt:StudyProduct_608de4f2-5325-32d0-8f68-c3fd942fe4a3|rdfs:label|StudyProduct_608de4f2-5325-32d0-8f68-c3fd942fe4a3 imgt:9838|rdfs:label|9838 _:B671ec60fcb2ac3e5cea67463f608d8d2|imgt:isDecidedBy|imgt:FDA imgt:MAbReceptor_74|rdfs:label|MAbReceptor_74 imgt:StudyProduct_4460729a-4b16-35cd-b240-876f2567a78b|imgt:isStudyProductOf|imgt:Product_b8b97efb-86a2-33a6-b3a8-01f88c1daea3 imgt:Segment_1225_1|rdfs:label|Segment_1225_1 imgt:StudyProduct_895e271b-202a-317d-a39f-fe20626fc86e|imgt:hasClinicalPhase|imgt:Phase_M imgt:Segment_1255_1|rdfs:label|Segment_1255_1 imgt:Construct_1281|imgt:isConstructOf|imgt:IgG1-lambda-kappa_1281 imgt:Segment_394_2|imgt:hasImgtLabel|imgt:IGHG4 pubmed:15994800|imgt:isBibliographicReferenceOf|imgt:mAb_94 obo:NCIT_C1474|rdfs:subClassOf|obo:NCIT_C1909 imgt:IgG4-kappa_1203|obo:RO_0002162|imgt:Hum imgt:Osteoporosis_postmenopausal_women|imgt:isClinicalIndicationOf|imgt:StudyProduct_e10fb030-a327-3e32-9249-263591627ebd imgt:StudyProduct_a15d6560-0651-3e4d-a9f9-d4c5e6f8d11f|imgt:hasClinicalPhase|imgt:Phase_II imgt:_CHO-K1|imgt:isExpressionSystemOf|imgt:StudyProduct_e1799e8f-13ac-3603-8792-720b056338d1 imgt:StudyProduct_fe441ab6-d6b4-390c-80a2-9be0f43c9d3b|imgt:hasClinicalPhase|imgt:Phase_II imgt:CD70|imgt:isTargetOf|imgt:MAbReceptor_514 imgt:mAb_128|imgt:inn_recommended_list|35 (1995) imgt:StudyProduct_3114e87f-1cdb-3dbb-9326-bcde5d342889|rdfs:label|StudyProduct_3114e87f-1cdb-3dbb-9326-bcde5d342889 imgt:StudyProduct_94857d13-f5a5-38b1-8d94-5d1cfb81ee60|imgt:isStudyProductOf|imgt:Product_c7cf4dec-df13-33c9-9a7e-798c0993539c imgt:StudyProduct_afa4e4b2-72ed-30e2-b398-0e6843dde2fa|imgt:hasDecision|_:B3ee3fd8f2ed78f37a30b99937e5417f7 imgt:Product_950458ce-5b79-3a87-87fd-0d76107f13a3|imgt:hasStudyProduct|imgt:StudyProduct_cb7167ad-d7e4-3970-8752-f2a0b6b7e5e5 imgt:CD47|imgt:isTargetOf|imgt:IgG4-kappa_1066 imgt:StudyProduct_16d4da35-58bb-399a-894b-7f3c3443aab9|imgt:isStudyProductOf|imgt:Product_00bacc20-6ab0-3330-acf7-f6cdf2e390a8 imgt:Clone_126|rdf:type|obo:NCIT_C37925 imgt:J-MOTIF|rdfs:label|J-MOTIF imgt:StudyProduct_4753c316-f20e-330a-b025-1aeef079ec42|imgt:hasClinicalPhase|imgt:Phase_III imgt:2FGW|imgt:isImgtStructureEntryOf|imgt:mAb_46 imgt:IG-Heavy-Gamma-2-b-IGHG2B|imgt:defines|imgt:IgG2b_Kappa imgt:StudyProduct_9956daea-9485-3ff6-953b-301e631be9e2|imgt:isStudyProductOf|imgt:Product_00ade453-d15c-3978-9598-f6299449d14e imgt:Product_5c0aac93-e5ec-3675-b1ef-16f7fbe485d4|imgt:isProducedBy|imgt:Novartis_Pharmaceuticals_Corp imgt:11625|imgt:isImgtStructureEntryOf|imgt:mAb_1168 obo:BFO_0000051|rdfs:range|faldo:Region imgt:StudyProduct_624f84ca-f52b-3a1c-8c31-9d3e5868f307|imgt:application_type|Therapeutic imgt:Bayer_HealthCare_Pharmaceuticals|rdfs:label|Bayer HealthCare Pharmaceuticals imgt:ICOS|imgt:isTargetOf|imgt:IgG1-kappa_801 imgt:mAb_229|imgt:hasImgtStructureEntry|imgt:9226 imgt:mAb_1171|rdfs:label|mAb_1171 imgt:IgG1-kappa_788|rdfs:comment|IgG1 - kappa imgt:Segment_184_1|rdf:type|imgt:Segment imgt:Product_ba16bede-241a-3cbe-9851-2b007ff0211d|imgt:hasStudyProduct|imgt:StudyProduct_4885c462-bdd8-3ecc-8e8c-51aef23a087a imgt:Product_827a202e-1f6c-316d-b5b0-b1ebd391a8c6|imgt:hasStudyProduct|imgt:StudyProduct_3fe8e925-30b8-30ce-8efb-22088860ac21 imgt:Product_91dd13bd-ad80-3827-8858-249f91b20ff5|imgt:isProductOf|imgt:mAb_128 imgt:StudyProduct_54fafb51-6774-36d0-995a-b42da3cb9585|rdf:type|obo:NCIT_C174271 imgt:Clone_23|rdf:type|obo:NCIT_C37925 imgt:Segment_983_1|obo:BFO_0000050|imgt:Construct_983 imgt:GH1*01(Pr27-217)|skos:definition|Somatotropin imgt:Product_9bc66176-d2dc-31b3-aa83-29aeeafd4d04|imgt:commun_name|anti-dabigatran imgt:StudyProduct_ea0afbf7-0368-37d0-9d22-e22c3668a661|rdfs:label|StudyProduct_ea0afbf7-0368-37d0-9d22-e22c3668a661 imgt:mAb_1158|rdf:type|obo:NCIT_C184840 imgt:mAb_433|rdfs:label|mAb_433 imgt:VIRLabel|rdfs:label|VIRLabel imgt:Product_ac4234a5-6b5e-3bf3-94f4-def2b50f16fd|imgt:isProductOf|imgt:mAb_139 _:Be60d2233056790b787525c2216cfaf69|rdf:type|obo:NCIT_C53285 imgt:Construct_1208|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Cancers_non-small_cell_lung_(NSCLC)|imgt:isClinicalIndicationOf|imgt:StudyProduct_8f55d686-8290-361c-8038-b10f381fb217 _:Bcc8eb25680981e5c15a452a276684845|imgt:isDecisionOf|imgt:StudyProduct_eef974a7-9264-3494-9f6b-be082ea96452 imgt:StudyProduct_a31d4482-170f-389c-9899-0da1c502dfa7|imgt:hasClinicalIndication|imgt:Cancers_prostate imgt:mAb_908|imgt:hasImgtStructureEntry|imgt:10975 imgt:isOriginCloneOf|rdf:type|owl:ObjectProperty imgt:Segment_783_1|obo:BFO_0000050|imgt:Construct_783 imgt:mAb_1003|imgt:clinical_trials|1 studies found, 1 recruiting imgt:mAb_474|imgt:clinical_trials|11 studies found, 1 recruiting imgt:IG-GAMMA-2-A_LAMBDA|rdf:type|imgt:StructureLabels imgt:Construct_1104|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:mAb_809|imgt:hasMabReceptor|imgt:IgG4-kappa_809 imgt:mAb_551|imgt:inn_number|9976 imgt:CIS_Bio_international|rdfs:comment|Bagnols/C , France imgt:Clone_162|imgt:isOriginCloneOf|imgt:mAb_162 imgt:IgG_Lambda|imgt:isDefinedBy|imgt:IG-Heavy-Gamma imgt:Product_ac4234a5-6b5e-3bf3-94f4-def2b50f16fd|rdf:type|obo:NCIT_C51980 imgt:StudyProduct_d84bded9-4720-3ab6-acaf-6d8202bfa9d7|imgt:hasClinicalIndication|imgt:Lymphoma_B_cell imgt:IG-Light-Kappa-IGKC|imgt:defines|imgt:Fab-Gamma-2_Kappa imgt:mAb_281|imgt:inn_recommended_list|46 (2001) imgt:Construct_408|imgt:hasImgtLabel|imgt:IGHG1_Fc_(Fragment_constant)-%5Bpeptide_14-mer-peptide_14-mer%5D2 imgt:IgM-kappa_129|imgt:hasConstruct|imgt:Construct_129 imgt:Hematologic_malignancies|imgt:isClinicalIndicationOf|imgt:StudyProduct_f3f90a44-ad85-3097-8693-98c7a6e9f52f imgt:Product_df8967e5-5089-3688-ab7d-c0aa071a918e|rdf:type|obo:NCIT_C51980 imgt:Product_18e218fa-ac0d-39a4-9e01-9513fbb2bc7c|imgt:isProducedBy|imgt:Amunix imgt:THB_conjugated_1115|imgt:hasConstruct|imgt:Construct_1115 _:B571a4abf6f04e928f194da0fbbf71526|rdf:type|obo:NCIT_C53285 imgt:StudyProduct_990d9537-fad6-3727-a623-6279efbdf49a|imgt:hasClinicalPhase|imgt:Phase_I imgt:mAb_357|rdf:type|imgt:INN imgt:Product_0d196a0b-ad4e-34ad-b360-537cee190370|imgt:hasStudyProduct|imgt:StudyProduct_d32090e7-fae7-3e87-9f1f-01cdccb6a415 imgt:Construct_1187|imgt:hasImgtLabel|imgt:IgG4-kappa imgt:Product_2b1f1b1c-e23b-39f4-85da-f7f86eccdf32|imgt:commun_name|ALB-rG-CSF imgt:StudyProduct_d901af09-1ed2-3cfd-87a0-6cebfcfe40e5|imgt:development_technology| Medarex's HuMAb-Mouse® imgt:IgG1-kappa_547|rdf:type|imgt:MAbReceptor imgt:Product_a75e30cc-34a4-3dcd-be39-36d249d9bb92|imgt:hasStudyProduct|imgt:StudyProduct_6144f41f-4c54-3c4d-9c59-2a2174eb9b09 imgt:StudyProduct_5335348c-cd60-3fb3-a01c-4588efc82101|imgt:hasDecision|_:B840b2cac76f60fe91f2bac693b0fd783 imgt:Chronic_granulomatous_disease_(CGD)|imgt:isClinicalIndicationOf|imgt:StudyProduct_b9686c63-50ec-3155-b913-7bb91f9942bc imgt:Product_c48dacde-0411-3136-a504-67d0e67b07e5|imgt:comercial_name|ABthrax® imgt:IgG1-kappa_322|imgt:hasConstruct|imgt:Construct_322 imgt:Product_6ef331a9-b7c2-3835-b601-a1cdf2e62923|imgt:commun_name|sclerostin Ab imgt:Construct_736|imgt:hasImgtLabel|imgt:IgG-nd imgt:Segment_438_1|imgt:hasImgtLabel|imgt:IgG1-nd imgt:Clone_225|rdf:type|obo:NCIT_C37925 imgt:V-D-J-CLUSTER|rdfs:label|V-D-J-CLUSTER imgt:functional|dc:identifier|imgt_000047 imgt:StudyProduct_823c31f0-c5d8-3976-9843-0963a819e426|imgt:development_technology| Abgenix's XenoMouse® imgt:Construct_1248|imgt:hasImgtLabel|imgt:(scFv-kappa-heavy)-G1_L-kappa-(scFv-heavy-kappa)-(scFv-heavy-kappa) _:B62891c00844c1e7f5d1c2509ccf7b848|rdf:type|obo:NCIT_C53285 imgt:Psoriatic_arthritis_(PSA)|imgt:clinical_domain|Immunology _:Bcf165fec7b47d9588389e1b30d72da7b|imgt:isDecisionOf|imgt:StudyProduct_03b7ff0f-2d1f-3a11-b8bd-d1b049ee566b imgt:IgG1-nd_680|rdf:type|imgt:MAbReceptor imgt:CytomX_Therapeutics_Inc|rdfs:comment|South San Francisco , USA imgt:IgG4-lambda_171|http://semanticscience.org/resource/SIO_000291|imgt:IL13 imgt:mAb_892|imgt:inn_number|10922 imgt:hasConstruct|rdfs:label|hasConstruct imgt:mAb_666|imgt:hasImgtStructureEntry|imgt:10319 imgt:_Murine_ascites,_pepsin_digestion|rdfs:label| Murine ascites, pepsin digestion imgt:Product_e808844d-6372-3f4f-acc9-93010ad0252a|imgt:commun_name|JSP191 imgt:Construct_97|rdf:type|imgt:Construct imgt:Product_ccaee58d-d4c1-3c86-90f0-df9bb7bf2ae1|imgt:hasStudyProduct|imgt:StudyProduct_8c63dc3d-4414-3596-928d-549fc6f3f5b1 imgt:IgA2_Kappa|imgt:isDefinedBy|imgt:IG-Heavy-Alpha-2-IGHA2 imgt:Segment_376_1|imgt:has_rank|1 imgt:CD3|rdf:type|owl:Class imgt:mAb_500|imgt:imgt_note| vanucizumab INN definition is the one amended in L113 (2015) and published in R73 (2015). imgt:StudyProduct_867c7dc8-fe17-3e79-ac2c-b955cdbe3a19|imgt:hasClinicalPhase|imgt:Phase_I imgt:VH-CH1|imgt:describes|imgt:IG-Heavy-Gamma-2-b-IGHG2B imgt:Product_b7184345-eea1-31c7-8d7d-cf29e2d424aa|imgt:isProductOf|imgt:mAb_133 imgt:Product_930f683b-b5a4-3e8e-8086-62a0f772efc7|rdf:type|obo:NCIT_C51980 imgt:Product_46b4bfd0-03aa-3d3b-92b8-d9d8b3476189|rdfs:label|Product_46b4bfd0-03aa-3d3b-92b8-d9d8b3476189 imgt:Product_a8c88a00-55f6-36e4-a163-a5e3d16adab7|imgt:hasStudyProduct|imgt:StudyProduct_a8c88a00-55f6-36e4-a163-a5e3d16adab7 obo:NCIT_C174871|rdf:type|owl:Class imgt:Segment_546_1|rdfs:label|Segment_546_1 pubmed:11373411|dc:date|2001 imgt:half-G1-kappa_scFv-HEAVY-LAMBDA-h-CH2-CH3_920|http://semanticscience.org/resource/SIO_000291|imgt:IL3RA imgt:mAb_1257|imgt:hasImgtStructureEntry|imgt:12054 imgt:(scFv-kappa-heavy)-(scFv-heavy-kappa)|imgt:construction_detail|(scFv - kappa - heavy) - (scFv - heavy - kappa) imgt:Product_8a6a655e-c029-3db0-abba-ab5a2dc29089|imgt:isProducedBy|imgt:Medarex obo:NCIT_C155976|rdfs:subClassOf|obo:NCIT_C1909 imgt:StudyProduct_98be9812-135f-3199-8453-fb46a2954524|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_163d3209-b354-3651-af01-31d9aea18d8b|rdfs:label|StudyProduct_163d3209-b354-3651-af01-31d9aea18d8b imgt:Segment_1033_1|rdfs:label|Segment_1033_1 _:B1210e9664b81d576423be0ec39f91950|rdf:type|obo:NCIT_C53285 imgt:Lymphoma_follicular_(FL)|rdfs:label|Lymphoma_follicular_(FL) imgt:FUSION-TNFSF10-GAMMA-1|rdfs:label|FUSION-TNFSF10-GAMMA-1 imgt:StudyProduct_a3efdb33-e7a0-3712-96a4-1d95f7771e48|imgt:application_type|Therapeutic imgt:G-ALPHA2-LIKE|rdf:type|imgt:G-LIKE-DomainLabel imgt:IgG1-kappa_414|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:Chugai_Pharmaceutical_Co_Ltd|imgt:produces|imgt:Product_22e71cb5-4fe7-3627-8a07-360ee7654a02 imgt:mAb_751|imgt:hasMabReceptor|imgt:MAbReceptor_751 imgt:Construct_870|obo:BFO_0000051|imgt:Segment_870_1 imgt:mAb_300|imgt:inn_name|vedolizumab imgt:IgG1-kappa_176|http://semanticscience.org/resource/SIO_000291|imgt:CD40 imgt:Construct_1071|obo:BFO_0000051|imgt:Segment_1071_1 imgt:Construct_863|imgt:hasImgtLabel|imgt:IgG4-kappa pubmed:8095956|dc:contributor|Bush BL imgt:Malignant_ascites|rdfs:label|Malignant_ascites imgt:Product_3fbfe977-f5f9-381b-94d0-489e229f2eaf|imgt:isProducedBy|imgt:Amgen imgt:Fc-Gamma-2-c|imgt:isDefinedBy|imgt:IG-Heavy-Gamma-2-c-IGHG2C imgt:IgG1-kappa_937|http://semanticscience.org/resource/SIO_000291|imgt:MET imgt:Product_91cb264b-0c51-33f5-8f57-97e282af35f0|rdfs:label|Product_91cb264b-0c51-33f5-8f57-97e282af35f0 imgt:mAb_713|rdf:type|obo:NCIT_C166557 imgt:flixabi®|rdf:type|obo:NCIT_C156644 imgt:IgG1-nd_MM_305|obo:RO_0002162|imgt:Musmus imgt:mAb_241|imgt:imgt_note| ibalizumab is currently being developed by TaiMed Biologics but was originally developed by Tanox Inc. (Houston, TX, USA), now part of Genentech. As part of Genentech's takeover of Tanox, the patent for ibalizumab was sold to TaiMed Biologics, a biotech company formed in 2007 in Taiwan. bMode of action/b. ibalizumab binds CD4, the primary receptor for HIV, and inhibits HIV from entering cells. It is a post-attachment inhibitor, blocking HIV from binding to the CCR5 and CXCR4 co-receptors after HIV binds to CD4 on the surface of a CD4+ T cell. By targeting HIV-1 entry before coreceptor binding and fusion have taken place, ibalizumab acts broadly on CCR5 and CXCR4 tropic strains.br/ibalizumab and MH2 proteins bind CD4 on different epitopes localized on [D2] and [D1], respectively, and Ibalizumab does not appear to interfere with CD4-dependent immunity. (Emu B. et alPhase 3 Study of ibalizumab for Multidrug-Resistant HIV-1.br/https://www.nejm.org/doi/full/10.1056/nejmoa1711460 Fig. S1 in Supplementary Appendix ). imgt:StudyProduct_498cf157-d9e4-3845-ab8e-e84d45abd28d|imgt:application_type|Therapeutic imgt:mAb_1140|imgt:inn_proposed_list|124 (2020) imgt:AIDS-related_Kaposi's_sarcoma|imgt:isClinicalIndicationOf|imgt:StudyProduct_c3a58be7-6f2c-3796-84c1-70f8564ad24a imgt:Product_3f761eab-e4ff-3721-a3de-e81704c29f01|imgt:isProducedBy|imgt:Amgen imgt:LRR8|skos:definition|Leucine-rich repeat imgt:Product_6700b7b7-e2af-3ee8-873f-cb4f2bdca604|imgt:isProducedBy|imgt:TG_Therapeutics imgt:CPCA_PEPTIDE-PEG-FC_673|imgt:hasConstruct|imgt:Construct_673 imgt:Chronic_lymphocytic_leukemia_(CLL)|imgt:isClinicalIndicationOf|imgt:StudyProduct_15d341a9-fce9-3f04-ba43-7569997016af imgt:Fc-Gamma-2-c|rdf:type|imgt:ReceptorType imgt:Segment_331_1|imgt:hasImgtLabel|imgt:ACVR2A _:B399ad07b178a70d6a7fe52f31992bd64|rdf:type|obo:NCIT_C53285 imgt:IgG1-kappa_945|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:Construct_723|obo:BFO_0000051|imgt:Segment_723_1 imgt:mAb_64|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=64 imgt:Peripheral_Arterial_Disease_(PAD)|imgt:isClinicalIndicationOf|imgt:StudyProduct_15bfb8dd-543a-30d8-b252-cae3eafb8727 imgt:Product_1c249114-8945-30c8-b7cd-23b872aa2f80|imgt:hasStudyProduct|imgt:StudyProduct_fade80e3-dac2-35bc-8e4a-2c6290e838ca imgt:hasTaxonomyRelatedStructureType|rdfs:range|imgt:TaxonomyRelated_StructureType imgt:Construct_149|obo:BFO_0000051|imgt:Segment_149_1 imgt:mAb_434|rdf:type|obo:NCIT_C1909 imgt:FUSION-IL1R1-GAMMA-1|skos:definition|IL1R1 fused with G1 H-CH2-CH3 imgt:Alder_Biopharmaceuticals_Inc|imgt:produces|imgt:Product_3f09e6a8-dad0-3689-9e50-6e9dbb7a5805 imgt:11947|imgt:isImgtStructureEntryOf|imgt:mAb_1273 imgt:StudyProduct_aef39d48-b873-32ee-8aeb-83e40098c167|imgt:hasClinicalPhase|imgt:Phase_I imgt:mAb_519|imgt:imgt_note| Provisional information for species is from the company web site Innate pharmaa (Accessed online on 25/06/17) lacutamab CAS number is that amended in L121 (2019). imgt:StudyProduct_4778a46d-c73d-3a03-9a1f-5b7d0dabf9c3|imgt:hasExpressionSystem|imgt:_Sp2/0_mouse_hybridoma_cells _:B31d6891c5e1ec320871688b45b299b2a|imgt:isDecisionOf|imgt:StudyProduct_64f62fb8-c9d6-33e3-a84a-a8a9713b02e3 imgt:12009|imgt:isImgtStructureEntryOf|imgt:mAb_1218 imgt:Psoriasis|imgt:isClinicalIndicationOf|imgt:StudyProduct_b184eb22-771a-392e-9d61-6646f94d32ca imgt:mAb_929|imgt:inn_proposed_list|120 (2018) imgt:IgG1-kappa_553|rdfs:label|IgG1-kappa_553 imgt:mAb_414|imgt:hasProduct|imgt:Product_5263e9de-956e-3cc5-9f06-d8273ad3417e imgt:half-G1-kappa_scFv-HEAVY-LAMBDA-h-CH2-CH3_920|imgt:hasConstruct|imgt:Construct_920 imgt:mAb_1160|imgt:inn_number|11534 imgt:Product_eea47d07-89ad-3942-ae9e-4016eb771f1a|imgt:isProductOf|imgt:mAb_71 _:B37a49294da2654e4acfe4ef089c10100|imgt:hasStatut|imgt:approval imgt:Construct_1142|imgt:hasImgtLabel|imgt:IgG4-kappa imgt:mAb_285|imgt:hasMabReceptor|imgt:IgG1-kappa_285 imgt:mAb_1233|imgt:inn_recommended_list|87 (2022) imgt:Product_05e5be80-e208-3f76-b968-e0554e88cdc8|imgt:isProducedBy|imgt:Centocor_Inc imgt:CD3E|skos:definition|Chain or receptor comprising a CD3E domain imgt:Product_c92f28b1-5553-3365-b529-29749116a0bc|imgt:commun_name|unconjugated: MLN2045 or 5F9 _:B150ff4626a9f7b6cd3ed3da9a301a4ea|imgt:isDecisionOf|imgt:StudyProduct_41b94ce1-b65d-37bc-aa0f-a71002c3a9ae imgt:Segment_998_1|imgt:has_rank|1 imgt:Allergy|rdfs:label|Allergy imgt:StudyProduct_14e61c20-cab3-33d1-a4bb-d83099d452ed|imgt:isStudyProductOf|imgt:Product_8e8a1379-1ce0-3a6f-bd30-ded74b8a8b53 imgt:10665|rdfs:label|10665 imgt:Acute_myeloid_leukemia_(AML)|imgt:isClinicalIndicationOf|imgt:StudyProduct_702ba1e4-9623-3711-a85b-44cab303d452 imgt:IG-Heavy-Alpha-2-IGHA2|rdf:type|imgt:ChainType imgt:Construct_386|imgt:hasImgtLabel|imgt:IgG4-kappa _:B896840c02032358f107d9a350da23b4c|imgt:isDecidedBy|imgt:FDA imgt:IgG1-kappa_790|imgt:hasConstruct|imgt:Construct_790 imgt:Product_508e2008-3ac6-3a20-8b85-3bae9bb94b1f|imgt:commun_name|NM57 imgt:StudyProduct_e0f17b9d-d2b9-3e09-a385-03d5a433a25d|imgt:hasClinicalIndication|imgt:Osteoporosis_postmenopausal_women imgt:IG-Light-Kappa-IGKC|imgt:defines|imgt:IgA_Kappa imgt:IgG3-kappa|rdfs:label|IgG3 - kappa imgt:Product_13305875-62ad-30ab-800f-d8785a528b64|imgt:hasStudyProduct|imgt:StudyProduct_915b5f50-b0b1-32e8-bfe4-41f3900cc292 imgt:IgG2-kappa_723|imgt:hasMolecularComponent|imgt:IG imgt:Segment_997_1|rdf:type|imgt:Segment imgt:IgG1-kappa_1151|rdfs:label|IgG1-kappa_1151 imgt:IgG1-kappa_753|http://semanticscience.org/resource/SIO_000291|imgt:CLDN18 imgt:TNFRSF12A|rdfs:label|TNFRSF12A imgt:StudyProduct_2ad9d678-26a3-3db3-bc03-8bc7cb226cac|imgt:hasClinicalIndication|imgt:Type_2_diabetes_(T2_DM) imgt:Segment_1079_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:mAb_869|imgt:hasMabReceptor|imgt:IgG1-lambda-%5BPROTEIN%5D2_869 imgt:mAb_77|imgt:inn_recommended_list|46 (2001) imgt:IgG1-nd_439|rdfs:comment|IgG1 - nd _:B90cbd8c644ba6521a322d986f4cc35e0|imgt:isDecidedBy|imgt:FDA imgt:StudyProduct_fe38caba-b9bf-359c-8993-63e9560277bd|imgt:hasClinicalIndication|imgt:Rheumatoid_arthritis_(RA) imgt:StudyProduct_a0d85c1a-e8a8-32c7-a7d3-b4736de24f27|rdf:type|obo:NCIT_C174271 imgt:Severe_sepsis_and_early_septic_shock|rdf:type|obo:NCIT_C185637 imgt:PEPTIDE_706|imgt:hasConstruct|imgt:Construct_706 imgt:Product_ab1469c5-6914-33ba-a094-bef28a95f7f3|imgt:commun_name|VR-942 imgt:StudyProduct_40f1808f-c7aa-3636-b5cf-33b05a8e334c|imgt:hasClinicalPhase|imgt:Phase_I/II imgt:Hepatitis_C|imgt:isClinicalIndicationOf|imgt:StudyProduct_bd3a5690-76d8-3798-bc05-a5cc72b447c9 imgt:mAb_1130|imgt:hasMabReceptor|imgt:IgG1-kappa_1130 imgt:mAb_326|imgt:inn_proposed_list|102 (2009) imgt:StudyProduct_3d9c8b9c-4fa4-3ef1-b3cf-ea6581c2bab5|rdf:type|obo:NCIT_C174271 imgt:Product_2ecc0951-7b88-3a39-9292-ecc5d34fd607|rdfs:label|Product_2ecc0951-7b88-3a39-9292-ecc5d34fd607 imgt:half-G1-kappa_scFv-HEAVY-LAMBDA-h-CH2-CH3_919|obo:RO_0002162|imgt:Hum imgt:StudyProduct_94c0040f-b4c8-3e29-9d30-5d34c53c3c22|imgt:hasClinicalPhase|imgt:Phase_I imgt:StudyProduct_8eac3427-fe5b-3005-a475-4555908e9884|rdf:type|obo:NCIT_C174271 imgt:mAb_1013|rdf:type|obo:NCIT_C168617 imgt:StudyProduct_61ff2dc5-66d9-3ec3-97ff-4109958d9b78|imgt:isStudyProductOf|imgt:Product_1f926dbc-c738-3aa1-a4fc-1a5a0ec04af8 imgt:Product_72b94469-e1c9-3b0f-95ab-b167ceab0072|imgt:commun_name|DI-17E6 imgt:TR-V-GAMMA-C-BETA-2|rdf:type|imgt:ChainLabels imgt:mAb_536|rdf:type|imgt:INN imgt:Segment_668_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Product_f272da3d-d319-39ce-a72e-2eaf8b604878|rdfs:label|Product_f272da3d-d319-39ce-a72e-2eaf8b604878 imgt:MH-Gene|skos:definition|Major histocompatibility Gene. imgt:StudyProduct_0580ff00-ac12-38a2-ab70-73623c2eea2e|imgt:hasClinicalPhase|imgt:Phase_M obo:NCIT_C165507|rdf:type|owl:Class imgt:StudyProduct_0f0dd0bb-f4b9-34f4-acf1-c931e5292c31|imgt:hasDecision|_:B353b778d16c846d7459a99d4de2a33f1 imgt:StudyProduct_c0ffec3c-ac52-3c49-9b5e-457434b1b4a4|rdfs:label|StudyProduct_c0ffec3c-ac52-3c49-9b5e-457434b1b4a4 imgt:Product_74d376fb-ff8e-340f-a10b-23eefb61dbad|imgt:hasStudyProduct|imgt:StudyProduct_6cc2dfda-fb6c-350b-92d8-2a860dbdd091 imgt:11808|rdf:type|obo:NCIT_C25402 imgt:Product_50c728d9-1b75-34fb-a648-dd8d841f3a78|rdf:type|obo:NCIT_C51980 imgt:IgG4-kappa_678|imgt:hasMolecularComponent|imgt:IG imgt:mAb_86|imgt:inn_proposed_list|77 (1997) imgt:Heterozygous_familial_hypercholesterolemia_(HeFH)|imgt:isClinicalIndicationOf|imgt:StudyProduct_ba4d951e-19b0-3ee4-8608-c8dd1945e860 imgt:IgG1-kappa_812|rdf:type|imgt:MAbReceptor imgt:StudyProduct_80a12eef-78f8-319c-9b8b-3bc915c82956|imgt:application_type|Therapeutic imgt:mAb_470|imgt:inn_recommended_list|71 (2014) imgt:Construct_244|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Clone_196|rdf:type|obo:NCIT_C37925 imgt:mAb_500|imgt:inn_proposed_list|111 (2014) imgt:Cancers_breast_triple_negative_(TNBC)_metastatic|rdf:type|obo:NCIT_C185637 imgt:StudyProduct_f9ebad83-378a-39ab-9408-576c062cfcdf|imgt:isStudyProductOf|imgt:Product_f54c6043-6277-3c37-b202-92f1deb4aaff imgt:IgG1-kappa_161|rdf:type|imgt:MAbReceptor imgt:StudyProduct_d8e204cf-0765-3d39-afdc-63016aeb34ef|imgt:hasClinicalPhase|imgt:Phase_M imgt:StudyProduct_49630eff-3c50-36c8-b562-6cd7a15dde73|imgt:isStudyProductOf|imgt:Product_eb402421-c224-38d4-94cb-61de3b050a04 imgt:F(AB%27)2-GAMMA-4_LAMBDA|skos:definition|F(ab')2 comprising the VH-CH1 domains from two H-GAMMA-4 chains and two L-LAMBDA chains imgt:mAb_324|rdfs:label|mAb_324 imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_66442d8f-2ea8-3e4e-b7bb-e1dd8b235ba0 imgt:IgG1-kappa_362|http://semanticscience.org/resource/SIO_000291|imgt:ITGAE_ITGB7 imgt:mAb_1207|rdf:type|imgt:INN imgt:tetravalent|imgt:isTargetOf|imgt:V-kappa-VH-V-lambda-VH%27_tandAb_1152 imgt:Product_95d79f23-a097-3b08-b973-202da2206ead|rdfs:label|Product_95d79f23-a097-3b08-b973-202da2206ead imgt:StudyProduct_630855cb-a105-355f-939c-b30d14d7c0d5|imgt:isStudyProductOf|imgt:Product_3b6c9b0a-cdb1-35e8-a5ba-246fdbd685e6 imgt:Clone_136|rdfs:label|Clone_136 imgt:CD274|imgt:isTargetOf|imgt:IgG1-lambda_946 imgt:StudyProduct_939b3314-6b35-370e-aadb-30c09a6e28f6|imgt:hasExpressionSystem|imgt:_CHOK1SV_(lacking_the_glutamine_synthetase_(GS)_gene)_cells imgt:StudyProduct_422e19e9-a276-3d9d-87fb-b3e6272ef962|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:mAb_640|imgt:inn_name|duvortuxizumab imgt:Rabies_post-exposure|imgt:isClinicalIndicationOf|imgt:StudyProduct_68144c19-458d-3c01-9bee-0b7e962fcf44 imgt:Product_d0619093-38ff-380c-9a52-fc7941cade23|rdf:type|obo:NCIT_C51980 imgt:J-SEQUENCE|imgt:imgt_link|http://www.imgt.org/IMGTScientificChart/SequenceDescription/displayimage.php?id=10 imgt:Product_35c6ca74-2743-3354-8965-d8ba06e48503|imgt:commun_name|3G3 imgt:Product_ce0f5967-53bd-3e4d-8a37-ca434333eb11|imgt:isProducedBy|imgt:Amgen imgt:StudyProduct_4ff3791f-430a-396c-b7dc-38fd60a2e83a|rdfs:label|StudyProduct_4ff3791f-430a-396c-b7dc-38fd60a2e83a imgt:Clone_1280|rdf:type|obo:NCIT_C37925 imgt:Clone_42|obo:RO_0002162|imgt:Musmus imgt:scFv-nd-nd_81|rdf:type|imgt:MAbReceptor imgt:Construct_369|imgt:isConstructOf|imgt:IgG2-kappa_369 imgt:mAb_1106|rdfs:label|mAb_1106 imgt:Sichuan_Clover_Biopharmaceuticals_Inc|imgt:produces|imgt:Product_823dd5e7-e3e3-3909-90c0-6b381ca01691 imgt:Product_508ac5a4-d670-3d35-8997-671e58d97871|imgt:isProducedBy|imgt:MedImmune imgt:11239|rdf:type|obo:NCIT_C25402 imgt:IgG1-kappa_766|rdfs:label|IgG1-kappa_766 imgt:mAb_203|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=203 imgt:Product_58a44815-3c5a-344f-960b-2c9d9ab2ae6d|rdf:type|obo:NCIT_C51980 imgt:HAVCR2|rdfs:label|HAVCR2 imgt:Merck_&_Co_Inc|imgt:produces|imgt:Product_c2f673d4-4d4a-3adb-886b-858a585b47df imgt:StudyProduct_6531837b-e221-3c84-b29d-98740ad35007|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:mAb_516|imgt:hasProduct|imgt:Product_2cc853dd-e3c6-3e19-a19e-85aa74315a15 imgt:Product_1aaa2a7e-6eb9-3729-a3c8-9ebd6913b871|imgt:commun_name|tezepelumab-ekko imgt:Segment_445_1|imgt:hasImgtLabel|imgt:IgG1-nd imgt:Product_ce822f79-054d-3661-8bf4-37f73f52daa5|imgt:comercial_name|CINQAIR imgt:StudyProduct_a4335940-34a0-3627-b2ea-b3c189aa7893|imgt:application_type|Therapeutic imgt:L-V-J-C-transcript|imgt:hasConfigurationType|imgt:R imgt:IgG1-lambda_1290|http://semanticscience.org/resource/SIO_000291|imgt:HIV-1 imgt:StudyProduct_0ae57c72-54b8-3d4b-95d8-e67013c22883|rdf:type|obo:NCIT_C174271 obo:NCIT_C162875|rdf:type|owl:Class imgt:Segment_94_1|rdf:type|imgt:Segment 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imgt:StudyProduct_b7b4c1db-df22-3f75-96fc-bfdd0e484d13|imgt:hasClinicalIndication|imgt:Age-related_macular_degeneration_(AMD)_neovascular_(wet) imgt:Product_00655a06-d268-361e-b76c-bddcf8215232|rdfs:label|Product_00655a06-d268-361e-b76c-bddcf8215232 imgt:Non-Hodgkin's_lymphoma_(NHL)|imgt:isClinicalIndicationOf|imgt:StudyProduct_d5c27e50-25d0-3bda-8182-e40b98934338 imgt:SCFV-DELTA-GAMMA|rdf:type|imgt:ChainLabels imgt:Clone_1168|rdfs:label|Clone_1168 imgt:bispecific|imgt:isTargetOf|imgt:half-G1-kappa_scFv-HEAVY-LAMBDA-h-CH2-CH3_920 imgt:Segment_1299_1|imgt:hasImgtLabel|imgt:IL2 _:B186c530203b38745b54f162d3b542583|rdf:type|obo:NCIT_C53285 imgt:Construct_1110|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:StudyProduct_4885c462-bdd8-3ecc-8e8c-51aef23a087a|rdfs:label|StudyProduct_4885c462-bdd8-3ecc-8e8c-51aef23a087a imgt:StudyProduct_7eed1a8e-d42d-3f3a-bba2-e7cb464b9202|imgt:application_type|Therapeutic imgt:Product_1316e8fc-c324-306e-97c8-ef0e1de0f57c|rdf:type|obo:NCIT_C51980 imgt:9300|rdf:type|obo:NCIT_C25402 imgt:StudyProduct_71e46760-7799-3358-acaf-2ab6daddc448|imgt:hasDecision|_:B6077f5c27d35cc5ca82749228a933c92 imgt:Clone_195|imgt:isOriginCloneOf|imgt:mAb_195 imgt:Fab-nd-nd_187|http://semanticscience.org/resource/SIO_000291|imgt:ICAM1 imgt:Product_1081ab17-8cd8-3029-854d-33096639ce86|imgt:hasStudyProduct|imgt:StudyProduct_2e13c6a2-af13-34bc-8e4c-5702a14274ce imgt:mAb_295|imgt:hasMabReceptor|imgt:IgG1-kappa_295 imgt:Product_c590bcda-c499-3148-b8e2-0bec3917880f|imgt:isProductOf|imgt:mAb_612 imgt:StudyProduct_cac1079e-e48e-330a-a7b6-9da80544e492|imgt:hasExpressionSystem|imgt:_E.coli_(Escherichia_coli) imgt:Biocad|rdf:type|obo:NCIT_C54131 pubmed:9099717|imgt:isBibliographicReferenceOf|imgt:mAb_7 imgt:StudyProduct_cce1cf27-9062-3c21-b311-6b2c23f33ced|imgt:hasClinicalPhase|imgt:Discontinued imgt:Segment_1256_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:IgG1-kappa_180|imgt:hasConstruct|imgt:Construct_180 imgt:mAb_383|imgt:inn_number|9428 imgt:Segment_406_1|imgt:has_rank|1 obo:NCIT_C155813|rdfs:subClassOf|obo:NCIT_C1909 imgt:mAb_1059|rdfs:label|mAb_1059 imgt:Clostridium_difficile_infectious_diarrhea|rdf:type|obo:NCIT_C185637 imgt:StudyProduct_fd5db05e-f2b2-3cd3-b10a-7e7f39c1aeff|imgt:application_type|Therapeutic _:Bf067e2db5b030a4e570331a107ec2108|rdf:type|obo:NCIT_C53285 _:B8d7a7e28f7dc579d3ec3ffd815e196ac|dc:date|2018-08-17 imgt:Product_643b4245-4368-3cc6-9e2e-c746cf6d7ea5|imgt:isProducedBy|imgt:MorphoSys imgt:mAb_554|rdf:type|imgt:INN imgt:HTRA1|obo:RO_0002162|imgt:Homsap imgt:IL15_(Pr49-162)|skos:definition|Interleukine 15 imgt:mAb_809|imgt:inn_proposed_list|118 (2017) imgt:IgG1-kappa_860|obo:RO_0002162|imgt:Hum imgt:mAb_326|imgt:inn_number|9182 imgt:Growth_hormone_(GH)_deficiency|rdf:type|obo:NCIT_C185637 imgt:Hepatitis_B|rdfs:label|Hepatitis_B imgt:Product_866ef94f-ee49-3c14-abc0-90cbc78d1192|imgt:commun_name|BITE MT112 imgt:Construct_1249|rdf:type|imgt:Construct imgt:V-D-J-gene|dc:identifier|imgt_000041 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imgt:FV-HEAVY_KAPPA|rdfs:label|FV-HEAVY_KAPPA imgt:Construct_56|imgt:hasImgtLabel|imgt:IgG1-nd imgt:Clone_91|rdf:type|obo:NCIT_C37925 imgt:StudyProduct_6ef39983-dbe2-33d9-a221-ce67c4fa0550|imgt:isStudyProductOf|imgt:Product_2d6c8b99-1554-3d56-b742-cd6247b80d36 imgt:Segment_1114_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:StudyProduct_74700ff0-ddc2-3caa-9e57-ca997439f9f4|imgt:isStudyProductOf|imgt:Product_a7b373c0-f329-3b03-b24e-41f48c77a159 imgt:Product_ad51ea1f-6af2-30b6-8138-6dbaa3800ad7|imgt:commun_name|RhuFab imgt:Construct_803|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Product_ffe79d3a-7340-3c62-883c-916bc4a8044e|rdf:type|obo:NCIT_C51980 imgt:FPIA_%5BPROTEIN%5D2-FC_475|rdfs:label|FPIA_[PROTEIN]2-FC_475 imgt:StudyProduct_50c57a82-84df-34c5-bed8-09d115373427|imgt:hasClinicalIndication|imgt:Rheumatoid_arthritis_(RA) imgt:Segment_1299_1|rdfs:label|Segment_1299_1 imgt:Product_2d6c8b99-1554-3d56-b742-cd6247b80d36|imgt:isProductOf|imgt:mAb_226 imgt:Segment_213_1|obo:BFO_0000050|imgt:Construct_213 imgt:IgG1-nd_280|rdfs:comment|IgG1 - nd imgt:StudyProduct_373d1dc7-9bed-3b86-8b62-1df9726e1173|imgt:hasClinicalIndication|imgt:Anemia imgt:Product_5fc8c641-ecc9-3932-a38f-e4883d55df69|imgt:hasStudyProduct|imgt:StudyProduct_ffef88d6-739a-374e-828d-ad5eee20ab3e imgt:IgG4-kappa_78|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG4-kappa.png imgt:Hepatitis_C_reinfection_in_liver_transplant_patients|imgt:clinical_domain|Infectiology imgt:FPIA_%5BPROTEIN%5D2-FC_1293|imgt:hasMolecularComponent|imgt:FPIA _:Bb43205bb67745f7bb180c22c9a89d373|rdf:type|obo:NCIT_C53285 imgt:IgG1-lambda_800|imgt:isMabReceptorOf|imgt:mAb_800 imgt:mAb_1072|imgt:hasOriginClone|imgt:Clone_1072 imgt:IgG1-kappa_1277|rdf:type|imgt:MAbReceptor imgt:Segment_234_1|imgt:has_rank|1 imgt:Segment_69_1|imgt:hasImgtLabel|imgt:IgG-nd _:B5ecdb45c3fc7b6bd6906aa8012f0342b|dc:date|2018-11-07 imgt:Clone_186|rdf:type|obo:NCIT_C37925 imgt:IgG1-nd_2|http://semanticscience.org/resource/SIO_000291|imgt:bispecific imgt:mAb_254|rdfs:label|mAb_254 imgt:StudyProduct_eba550c7-d4c5-3404-9bd1-41a9355ec09c|rdf:type|obo:NCIT_C174271 imgt:mAb_697|imgt:hasMabReceptor|imgt:HOR-CTP_697 imgt:Mersana_Therapeutics|rdf:type|obo:NCIT_C54131 imgt:Construct_806|rdfs:label|Construct_806 imgt:SCFV-BETA-ALPHA|skos:definition|scFv comprising a V-BETA and a V-ALPHA domains imgt:mAb_101|imgt:imgt_note| BITE® : bispecific T cell engager blinatumomab is the second approved bispecific antibody (the first one being catumaxomab in 2009 in EU). It is constructed by linking two scFv with a five amino acid linker ‘GGGGS’ (Mack M. et al. 1995, PMID: 7624362). In 2007, AstraZeneca bought MedImmune created in 1988. On Feb 14, 2019, it was announced that MedImmune will cease to exist as an industry name as the owner AstraZenaca has decided to retire the brand as part of ongoing restructuring efforts.https://www.biopharmadive.com/news/astrazeneca-retires-medimmune-name-amid-sales-turnaround/548489/ _:Bbcdffdd6ce2f37d5309d9b24cb4ab037|imgt:isDecidedBy|imgt:EMA imgt:Product_4e5a891b-d6e7-32c2-b255-14bceeb00397|imgt:commun_name|XmAb-23104 imgt:Construct_33|rdfs:label|Construct_33 imgt:Solid_tumors|imgt:isClinicalIndicationOf|imgt:StudyProduct_3d2935a7-28ab-378c-a5ef-6172395de77d imgt:Product_f58ea430-2a54-3467-bc94-a3af8a804da3|imgt:hasStudyProduct|imgt:StudyProduct_f4d00583-2c08-382e-bcfa-853bb79ccd6e imgt:StudyProduct_7c989237-1897-3d9b-bf0d-13cbd5682ac7|imgt:application_type|Therapeutic imgt:Construct_234|rdfs:label|Construct_234 imgt:IgG4-kappa_472|imgt:isMabReceptorOf|imgt:mAb_472 imgt:Clone_464|obo:RO_0002162|imgt:Musmus imgt:Acute_myeloid_leukemia_(AML)|imgt:isClinicalIndicationOf|imgt:StudyProduct_ae27ebd6-88cf-3350-b271-abd3ff3d5bc5 imgt:IgG1-nd_6|rdfs:comment|IgG1 - nd imgt:IgG4-kappa_30|obo:RO_0002162|imgt:Hum imgt:StudyProduct_c0747058-c28c-31fa-8364-f8475c60a950|imgt:hasClinicalIndication|imgt:Cancers_fallopian_tube imgt:CD38|imgt:isTargetOf|imgt:IgG4-kappa-protein_1019 imgt:VH-C-LIKE-CH1|rdf:type|imgt:ChainLabels imgt:StudyProduct_d0b9c36a-47a6-3ed4-963a-755e65fcf1c4|rdf:type|obo:NCIT_C174271 pubmed:7682986|dc:title|Construction of a reshaped HMFG1 antibody and comparison of its fine specificity with that of the parent mouse antibody. imgt:StudyProduct_22eab2bd-fcca-323d-b4ba-b74c6bac47a7|rdf:type|obo:NCIT_C174271 obo:NCIT_C166680|rdf:type|owl:Class imgt:IgG1-kappa_77|imgt:hasConstruct|imgt:Construct_77 imgt:11412|rdf:type|obo:NCIT_C25402 imgt:10385|imgt:isImgtStructureEntryOf|imgt:mAb_657 imgt:mAb_492|rdf:type|imgt:INN 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imgt:StudyProduct_30bb9ffe-becf-3cd4-a4cd-0a524df71a7d|imgt:hasClinicalPhase|imgt:Phase_M imgt:StudyProduct_1bb64584-3372-35f4-979c-739fd455f8fe|imgt:hasClinicalIndication|imgt:Cancers_breast_overexpressing_ERBB2 imgt:StudyProduct_3e24bf2b-d412-3149-819e-5cf5df517861|imgt:application_type|Therapeutic imgt:mAb_73|imgt:hasProduct|imgt:Product_475ec8af-d4f7-3fe4-82b1-ba8b12a3c69d imgt:Product_89e80ca8-7101-3ea6-b527-9c007f878e2b|imgt:isProducedBy|imgt:Trillium_Therapeutics_Inc imgt:IL4R|rdf:type|obo:NCIT_C25702 obo:RO_0001019|rdf:type|owl:ObjectProperty imgt:StudyProduct_71b75379-eb4c-3f15-b0fc-beda141a12a8|rdfs:label|StudyProduct_71b75379-eb4c-3f15-b0fc-beda141a12a8 imgt:IgG1-kappa-%5BPROTEIN%5D2_IFNA2_1157|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa-[PROTEIN]2_IFNA2.png imgt:DomainType|rdf:type|owl:Class imgt:Product_95d79f23-a097-3b08-b973-202da2206ead|imgt:hasStudyProduct|imgt:StudyProduct_d48c15b1-3cc2-3511-956e-3e5095cdf1ac imgt:StudyProduct_c6266a1e-643f-38b6-8f08-90e022c9365a|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_84412462-98e1-3c40-9555-38a0eebd9b4b|imgt:hasClinicalIndication|imgt:Cancers_small_cell_lung_(SCLC) imgt:Product_bb920c26-88f7-3605-b3b5-e5f956005067|imgt:isProducedBy|imgt:Merck_Serono_International_SA imgt:Clone_300|obo:RO_0002162|imgt:Musmus imgt:FPIA_%5BPROTEIN%5D2-FC_582|imgt:hasConstruct|imgt:Construct_582 imgt:Rhein-Minapharm|rdf:type|obo:NCIT_C54131 imgt:Product_a444fd94-b0b7-35fd-bc5c-4dd8b912eed1|imgt:isProducedBy|imgt:Pfizer imgt:Novartis_Pharmaceuticals_Corp|imgt:produces|imgt:Product_11743f52-8d52-3e88-b8df-04e83be3502a imgt:mAb_276|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=276 imgt:StudyProduct_1841856a-e1a3-384f-85a2-2da4d0096dd7|imgt:application_type|Therapeutic imgt:Segment_162_1|imgt:hasImgtLabel|imgt:IgG1-lambda imgt:Type_2_diabetes_(T2_DM)|rdf:type|obo:NCIT_C185637 imgt:Construct_41|imgt:isConstructOf|imgt:IgG1-nd_41 _:Bc4d745c98d70dfd1fe1105012bec4f95|rdf:type|obo:NCIT_C53285 imgt:StudyProduct_45967837-7a5b-388a-8270-99c8a7c5d163|imgt:isStudyProductOf|imgt:Product_6ef331a9-b7c2-3835-b601-a1cdf2e62923 imgt:Segment_497_1|imgt:has_rank|1 imgt:Construct_161|obo:BFO_0000051|imgt:Segment_161_1 imgt:StudyProduct_0895e1ef-0d19-3466-9423-f7b0a797c903|imgt:hasClinicalIndication|imgt:Rheumatoid_arthritis_(RA) imgt:Product_3d3847b0-2ca8-3154-aa57-18221948bd0d|imgt:hasStudyProduct|imgt:StudyProduct_1bc2e1b0-235f-3fd7-895d-a9145c6ef8b1 imgt:IgG4-kappa_1015|rdf:type|imgt:MAbReceptor imgt:mAb_952|imgt:hasProduct|imgt:Product_d0619093-38ff-380c-9a52-fc7941cade23 imgt:CALCB|skos:definition|CALCB (calcitonin-related polypeptide beta) imgt:%5BPEPTIDE-PROTEIN%5D3_818|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/[PEPTIDE-PROTEIN]3.png obo:NCIT_C166498|rdfs:subClassOf|obo:NCIT_C1909 imgt:IgG2-kappa_376|imgt:hasConstruct|imgt:Construct_376 imgt:mAb_225|imgt:clinical_trials|17 studies found, 2 recruiting imgt:FUSION-%5BCSF3%5D1-FC-GAMMA-4|skos:definition|Fusion protein for immune application (FPIA) comprising CSF3 fused with immunoglobulin G4 FC fragment imgt:StudyProduct_b9617fc0-a404-3cff-ac56-94d20bcda253|imgt:hasDecision|_:B8227e98020208d12ba38cb8da151085d imgt:Human_cytomegalovirus_(HCMV)|imgt:isClinicalIndicationOf|imgt:StudyProduct_e87ab206-c83e-3df7-887b-3c92776d9448 imgt:StudyProduct_0138d2f2-7c06-3036-b222-3f2c2f10cab5|imgt:isStudyProductOf|imgt:Product_ee3bfd28-f3fe-364b-ad74-fb9cebac452a imgt:Product_297a09a3-ed5b-3651-8ce5-22baa225b7cf|imgt:isProductOf|imgt:mAb_1015 imgt:Atopic_dermatitis_(AD)|imgt:isClinicalIndicationOf|imgt:StudyProduct_d08a20b2-9c23-3e4f-a00b-6f83c51732a6 obo:NCIT_C152484|rdf:type|owl:Class imgt:StudyProduct_2b7f353a-d8aa-3509-b95e-9945de9a63ae|rdfs:label|StudyProduct_2b7f353a-d8aa-3509-b95e-9945de9a63ae imgt:StudyProduct_be05a673-0f5d-34f9-84d2-fbfe1a49194a|imgt:application_type|Therapeutic imgt:bispecific|imgt:isTargetOf|imgt:MAbReceptor_996 imgt:F(AB%27)2-GAMMA-2_KAPPA|skos:definition|F(ab')2 comprising the VH-CH1 domains from two H-GAMMA-2 chains and two L-KAPPA chains imgt:FG-LOOP|rdfs:label|FG-LOOP imgt:IgG1-lambda_1109|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-lambda.png imgt:Construct_796|imgt:isConstructOf|imgt:%5BscFv-kappa-heavy-PROT%5D2_796 imgt:Construct_527|rdfs:label|Construct_527 imgt:mAb_287|imgt:hasMabReceptor|imgt:Fab-G1-kappa_287 imgt:IgG1-kappa_229|imgt:conjugated_with| chelator tetraxetan (DOTA) imgt:mAb_1297|imgt:hasMabReceptor|imgt:%5BPROTEIN-PROTEIN%5D3_1297 imgt:StudyProduct_c6c42e56-858c-354f-ba81-ed64d33f6552|imgt:hasClinicalIndication|imgt:Rheumatoid_arthritis_(RA) imgt:StudyProduct_f175da2f-c4f7-36e5-98a4-83da5714dd72|rdfs:label|StudyProduct_f175da2f-c4f7-36e5-98a4-83da5714dd72 imgt:PRG4|rdfs:label|PRG4 imgt:StudyProduct_1884c1fa-e53a-3bd2-b507-eae4c4c1906e|rdf:type|obo:NCIT_C174271 obo:NCIT_C54131|skos:definition|Any formal business entity for profit, which may be a corporation, a partnership, association or individual proprietorship. imgt:Clone_1248|rdf:type|obo:NCIT_C37925 imgt:Axial_spondyloarthritis_(axSpA)|imgt:isClinicalIndicationOf|imgt:StudyProduct_90fd282e-02f9-398a-be74-6e57271986c8 imgt:Segment_1038_1|rdf:type|imgt:Segment imgt:StudyProduct_02122574-90c0-3f84-9e7a-48bd2a464e48|rdfs:label|StudyProduct_02122574-90c0-3f84-9e7a-48bd2a464e48 imgt:Segment_688_1|imgt:segment_detail|recombinant (variant_011773) glycosylated (glycoform alfa) imgt:StudyProduct_2187556f-7069-36fb-a3b5-1eac6983f1c9|imgt:hasClinicalIndication|imgt:Graft-versus-host_disease_(GvHD) imgt:Product_485d748c-9ee2-352a-aaf4-3297a649c274|imgt:hasStudyProduct|imgt:StudyProduct_1bffc5d9-6be7-3f6f-aec0-82c150cfc547 imgt:StudyProduct_d482e648-a855-392b-b435-a0f08daa7abd|rdfs:label|StudyProduct_d482e648-a855-392b-b435-a0f08daa7abd 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imgt:Kiniksa_Pharmaceuticals_Ltd|rdf:type|obo:NCIT_C54131 imgt:7042|rdfs:label|7042 imgt:Product_188975ba-e8fc-3ccd-8368-e47522abda48|imgt:isProductOf|imgt:mAb_1218 imgt:IgG2-kappa_369|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG2-kappa.png imgt:F(AB')2-MU_LAMBDA|rdfs:label|F(AB')2-MU_LAMBDA imgt:mAb_161|imgt:hasBiosimilar|imgt:ritemyia imgt:StudyProduct_144729a6-6ff9-310e-bc60-c73ad5b42660|imgt:hasClinicalIndication|imgt:Melanoma imgt:StudyProduct_bb14a1cf-81cc-3fd3-b586-0eb76136c45f|rdfs:label|StudyProduct_bb14a1cf-81cc-3fd3-b586-0eb76136c45f imgt:StudyProduct_bf0c6988-2641-3c0a-8840-60eccf82f63b|imgt:development_technology| MorphoSys's HuCAL® phage library imgt:Segment_350_1|rdfs:label|Segment_350_1 imgt:Product_4a19313c-79ad-3816-90a3-6d5c4ee71379|imgt:commun_name|BAY 79-4620 imgt:F(ab)2-G3-kappa|rdfs:label|F(ab')2 - G3 - kappa imgt:StudyProduct_0c23c19c-5024-3083-90b4-416d2c92751d|rdfs:label|StudyProduct_0c23c19c-5024-3083-90b4-416d2c92751d imgt:Construct_277|rdf:type|imgt:Construct imgt:mAb_45|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=45 imgt:mAb_829|imgt:hasImgtStructureEntry|imgt:11471 _:B4b7a5f03b3e17b50eb4a4c4ac938b307|imgt:isDecidedBy|imgt:FDA imgt:mAb_386|rdf:type|obo:NCIT_C152838 imgt:StudyProduct_a234ffce-a68d-3cca-ab1e-c3c3af138d1d|imgt:application_type|Therapeutic imgt:INHBA|imgt:isTargetOf|imgt:IgG4-kappa_678 imgt:LRR23|rdf:type|imgt:RepeatLabel imgt:StudyProduct_edfc51c0-14ae-35bf-91cd-f83884016c01|rdfs:label|StudyProduct_edfc51c0-14ae-35bf-91cd-f83884016c01 imgt:mAb_183|imgt:inn_proposed_list|95 (2006) imgt:shiga_toxin_type_1|skos:definition|shiga toxin type 1 (shiga toxin-producing Escherichia coli (STEC), stx1, Stx1, Stx-1, Shiga-like toxin 1, SLT-1, SLT-I) imgt:Product_475ec8af-d4f7-3fe4-82b1-ba8b12a3c69d|imgt:comercial_name|NUMAX® imgt:7602|rdf:type|obo:NCIT_C25402 imgt:mAb_712|imgt:inn_number|10342 imgt:D-J-C-SEQUENCE|imgt:describes|imgt:D-J-C-sequence imgt:scFv-kappa-heavy-CD8A_(CO-TM)-N6_(CY)-CD247_1102|obo:RO_0002162|imgt:Chi imgt:V-gene|rdfs:label|V-gene imgt:ImmunoGen_Inc|imgt:produces|imgt:Product_c10a43ba-cfd6-3610-84b1-dabd23fd8ede imgt:CPCA_%5BPROTEIN_BIG%5D2-FC_395|rdfs:comment|CPCA_[PROTEIN_BIG]2-FC imgt:Cancers_breast|imgt:isClinicalIndicationOf|imgt:StudyProduct_c15a680a-df3f-3149-aba2-ca027116eef2 imgt:IFNLR1|skos:definition|IFNLR1 (interferon type III (lambda) receptor subunit 1) _:Be401e33d862bffa5c533efab1d93f4f4|imgt:isDecisionOf|imgt:StudyProduct_ea16d45e-73b3-3460-b29e-70cbd5dea9b5 imgt:TR-Locus-OrphonSet|rdfs:label|TR-Locus-OrphonSet imgt:Product_32616388-2f3b-3bc7-9429-693216dd67ab|imgt:commun_name|RO5553110 imgt:Segment_1177_1|obo:BFO_0000050|imgt:Construct_1177 imgt:Acticor_Biotech|imgt:produces|imgt:Product_8aab193e-5ea6-3d52-8519-ee1de15448f9 imgt:VH-VH%27-VH__trivalent_583|imgt:isMabReceptorOf|imgt:mAb_583 imgt:Fab-G4-nd_188|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/Fab-G4-nd.png imgt:IG-Heavy-Gamma-2-b-IGHG2B|rdf:type|imgt:GeneLevelChainType obo:NCIT_C79828|rdf:type|owl:Class imgt:mAb_1075|imgt:inn_name|zanidatamab zovodotin _:B8ddc97bc87100a40968d27bde3186c1f|imgt:isDecisionOf|imgt:StudyProduct_53334127-51ec-3e46-bb66-71919e3cce29 imgt:StudyProduct_7f9bf084-96c3-3f2d-8e68-adb339a07a1e|rdfs:label|StudyProduct_7f9bf084-96c3-3f2d-8e68-adb339a07a1e imgt:mAb_930|rdf:type|imgt:INN imgt:G1_L-kappa_VH-VH-h-CH2-CH3_1182|rdf:type|imgt:MAbReceptor imgt:Arsanis_Inc|rdfs:comment|Waltham , USA imgt:Product_13979b26-475c-3029-882e-aa3a12fb06d7|imgt:commun_name|LAPS-GLP-1/GCG imgt:CD276|skos:definition|CD276 (B7H3, B7-H3, B7-related protein 2, B7RP2, B7RP-2, B7 homolog 3, B7 homologue 3) imgt:IG-Heavy-Gamma-3-IGHG3|imgt:hasChainTypeLevel|imgt:IG-Heavy-Gamma imgt:Product_c111c6d3-f151-3e27-9849-24a4130043cd|imgt:commun_name|RG-6107 imgt:Solid_tumors|imgt:isClinicalIndicationOf|imgt:StudyProduct_bcd84b48-b116-3270-92e4-33d66f0c7e74 imgt:StudyProduct_de28736e-3e61-3b7a-9b0f-691a923e312a|imgt:application_type|Therapeutic imgt:Product_eee3061f-bf14-3e3d-9646-c7c2fe6d3166|rdf:type|obo:NCIT_C51980 imgt:AXL|imgt:isTargetOf|imgt:IgG1-kappa_813 _:Bf751eeac1d55e62bc05d2672ad73b8fa|imgt:hasDesignation|imgt:Orphan_drug imgt:F(AB')2-ALPHA_LAMBDA|rdfs:label|F(AB')2-ALPHA_LAMBDA imgt:StudyProduct_505c50fd-582b-39f6-a814-3ba9cee5db61|rdfs:label|StudyProduct_505c50fd-582b-39f6-a814-3ba9cee5db61 imgt:Construct_538|imgt:isConstructOf|imgt:IgG2-kappa_538 obo:NCIT_C166557|rdf:type|owl:Class imgt:Product_b73d2d86-860f-31ba-ad24-b3f898e384da|imgt:isProductOf|imgt:mAb_552 _:B2843600d6233016012068bf6f6d580ea|imgt:isDecidedBy|imgt:FDA imgt:Amgen|imgt:produces|imgt:Product_6a18513a-d0e4-37c5-80b2-122a63ee4ba2 imgt:Construct_1148|imgt:isConstructOf|imgt:IgG4-kappa_1148 imgt:StudyProduct_163e4859-4df9-3329-97e3-dc1e168bb762|imgt:development_technology| MorphoSys's HuCAL® phage library imgt:FUSION-SELPG-GAMMA-1|rdfs:label|FUSION-SELPG-GAMMA-1 imgt:IgG1-lambda_1216|imgt:hasMolecularComponent|imgt:IG _:B0125e788dd8a580ea5a131d557c2b4d0|imgt:isDecidedBy|imgt:FDA imgt:Product_5cde7219-6367-3651-8ae8-f6c007a0a286|imgt:hasStudyProduct|imgt:StudyProduct_57b720d4-eb61-3a57-a63e-623b59eb8f24 imgt:mAb_1141|imgt:inn_proposed_list|124 (2020) imgt:TransmembraneRegionLabel|rdfs:subClassOf|imgt:DomainLabels imgt:Construct_562|imgt:hasImgtLabel|imgt:IgG4-kappa imgt:mAb_933|imgt:hasProduct|imgt:Product_a23573c5-b373-324a-9d04-0e37a2bcdfa0 imgt:Construct_685|obo:BFO_0000051|imgt:Segment_685_2 imgt:8734|rdfs:label|8734 imgt:StudyProduct_c6c42e56-858c-354f-ba81-ed64d33f6552|imgt:isStudyProductOf|imgt:Product_576107d9-93d9-3b1e-8ddc-7f802eaadc09 imgt:IgG1-nd_435|obo:RO_0002162|imgt:Homsap imgt:Glanzmann's_thrombasthenia_(GT)|rdfs:label|Glanzmann's_thrombasthenia_(GT) imgt:mAb_1293|rdf:type|imgt:INN imgt:IgG1-kappa-4cys-drug_668|imgt:hasMolecularComponent|imgt:IG imgt:Product_e8622868-8b57-3e77-b971-d5d37d61b031|imgt:comercial_name|KEVZARA® imgt:mAb_221|imgt:hasProduct|imgt:Product_86caf914-ea0e-3a51-93ab-dc2203d9229f imgt:mAb_1006|rdf:type|obo:NCIT_C151967 imgt:mAb_1004|imgt:clinical_trials|1 studies found, 1 recruiting imgt:Cancers_non-small_cell_lung_(NSCLC)|imgt:isClinicalIndicationOf|imgt:StudyProduct_8e5e584f-e616-3b66-8159-45ca4319af19 imgt:Clone_197|rdf:type|obo:NCIT_C37925 imgt:Eosinophilic_granulomatosis_with_polyangiitis_(EGPA)_formerly_known_as_Churg-Strauss_Syndrome|imgt:isClinicalIndicationOf|imgt:StudyProduct_40fc8ece-1fab-3e40-9011-12e54af47f13 imgt:IgG1-nd_227|rdf:type|imgt:MAbReceptor imgt:Product_5c6f069e-5b7f-3b5e-8bc2-2580fdc050f8|imgt:isProducedBy|imgt:Agensys imgt:StudyProduct_773868e5-eff6-3aac-a866-62bdf844a898|imgt:isStudyProductOf|imgt:Product_07a0f8df-d456-3179-a3a2-ab802e7d3e13 imgt:StudyProduct_2a609cc8-d401-3b2d-bcfb-b58ecbcd588d|imgt:hasClinicalIndication|imgt:Type_2_diabetes_(T2_DM) imgt:Segment_199_1|imgt:hasImgtLabel|imgt:IgG3-kappa imgt:StudyProduct_997755ec-78d1-3d75-80b4-20ca997666bc|imgt:hasExpressionSystem|imgt:_CHO-K1 imgt:Product_262ab471-0054-380f-bcca-d0e91b8d0a82|imgt:hasStudyProduct|imgt:StudyProduct_3dd848dc-265a-30d8-ba58-470497ee2ecb imgt:StudyProduct_c2bc9b3a-a15e-376f-bda5-f87089b3f54b|imgt:application_type|Therapeutic imgt:Construct_106|imgt:hasImgtLabel|imgt:Fab%27-G1-kappa imgt:StudyProduct_bcd3d4d4-ac07-39e5-87b1-8595fdb28d97|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:Stroke|imgt:isClinicalIndicationOf|imgt:StudyProduct_b0dad6c0-b927-3321-8f38-6f26d945289d imgt:StudyProduct_dda793a3-6153-3e67-8e8c-30c859b184ba|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_8870f440-5d37-3ef9-bb0e-3c00ea5d4b1a|imgt:isStudyProductOf|imgt:Product_f5e55c8d-239e-36ce-b0ca-d43a9d2f3f03 imgt:StudyProduct_b12799c4-4250-3cf5-9055-370a69eac085|rdf:type|obo:NCIT_C174271 imgt:11649|rdfs:label|11649 imgt:PEPTIDE-PROTEIN_1292|imgt:hasMolecularComponent|imgt:CPCA imgt:TR-GAMMA-3_DELTA|imgt:describes|imgt:TR-Gamma-3_Delta imgt:StudyProduct_23e6cb85-b1f6-376c-a384-fd55c313f434|rdfs:label|StudyProduct_23e6cb85-b1f6-376c-a384-fd55c313f434 imgt:Carcinoma_nasopharyngeal_(NC)|imgt:isClinicalIndicationOf|imgt:StudyProduct_53334127-51ec-3e46-bb66-71919e3cce29 imgt:Clone_420|rdf:type|obo:NCIT_C37925 imgt:Clone_111|obo:RO_0002162|imgt:Musmus _:B94dd5d9cbe6add4da11806501e4367c3|imgt:isDecisionOf|imgt:StudyProduct_e10fb030-a327-3e32-9249-263591627ebd imgt:Segment_1059_1|obo:BFO_0000050|imgt:Construct_1059 imgt:Clone_43|imgt:isOriginCloneOf|imgt:mAb_43 imgt:StudyProduct_c0e7c06f-c62b-3fe8-a0ab-ff5b39e9b281|imgt:hasClinicalPhase|imgt:Phase_I imgt:mAb_171|imgt:hasImgtStructureEntry|imgt:9235 imgt:hapten_NP-cap|rdf:type|obo:NCIT_C25702 imgt:mAb_745|rdfs:label|mAb_745 imgt:Product_e307cb3e-aef8-35ec-8bfb-bee27d4d2030|imgt:hasStudyProduct|imgt:StudyProduct_24927660-46be-3320-af9b-3889951ff778 imgt:StudyProduct_aaf066df-3656-3025-80a3-0e31ed88ed73|imgt:application_type|Therapeutic imgt:StudyProduct_053d3539-2a6d-389b-a439-57ca9bc99d1c|imgt:application_type|Therapeutic _:B15e31c7d18125296a6a7f4f85f768f47|imgt:isDecisionOf|imgt:StudyProduct_937a3a90-3cba-3068-967b-7d14a1c3ac4e imgt:mAb_1084|imgt:inn_proposed_list|123 (2020) imgt:StudyProduct_d1e3b696-3c02-3d2b-88e8-b57f5a72c6df|imgt:isStudyProductOf|imgt:Product_c9cd5d6c-3e39-30c7-8a4f-47103005cdcf imgt:mAb_679|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=679 imgt:MADCAM1|obo:RO_0002162|imgt:Homsap imgt:StudyProduct_adf744e0-724f-3a47-aa93-52d0f375e490|imgt:hasDecision|_:B1d0329fd4270c8c6e5e960dd2124c344 imgt:Product_5fe90c16-d2de-3542-bba6-f7634ec51c07|imgt:hasStudyProduct|imgt:StudyProduct_1932e31c-ebfe-371f-90bc-94871b025a4b imgt:mAb_882|imgt:hasMabReceptor|imgt:IgG1-lambda_882 imgt:VH-VL-VH%27-VL%27-CH2-CH3_1054|imgt:hasMolecularComponent|imgt:IG imgt:Product_4cf2f354-03b0-3649-acb9-df3628a4e9e8|imgt:comercial_name|EPOGEN® imgt:Cancers_cervical|imgt:isClinicalIndicationOf|imgt:StudyProduct_bff647af-97f0-3130-ad25-6db937cf9c00 imgt:mAb_122|imgt:inn_name|ibritumomab tiuxetan imgt:Segment_1162_1|rdf:type|imgt:Segment imgt:StudyProduct_3365e494-cd15-3232-a8be-a08afe6dced2|rdfs:label|StudyProduct_3365e494-cd15-3232-a8be-a08afe6dced2 imgt:Product_67eb0a60-1489-389a-8509-6fd884738332|imgt:isProductOf|imgt:mAb_1173 imgt:mAb_406|imgt:inn_name|quilizumab imgt:StudyProduct_8d7975cb-13e4-34b9-80f4-71a0cba59723|imgt:hasClinicalPhase|imgt:Phase_M _:Bea6e7336a7e87c375155c8f9fcbe2314|imgt:isDecidedBy|imgt:FDA imgt:mAb_220|rdfs:label|mAb_220 imgt:Fab%27-R-Fab%27_220|rdfs:comment|Fab'-R-Fab' imgt:mAb_581|imgt:imgt_note| Human OX40 ligand fusion protein (MEDI6383) as a potent OX40 agonist and immuno-modulator in vitro and in vivo (Scott A Hammond, ASCO Annual Meeting , 2015). MEDI6383 is an agonistic anti-TNFRSF4 (OX40, CD134) fusion protein for immune applications (FPIA), which comprises TNFSF4 hexamer fused to IGHG1-Fc, and binds TNFRSF4 with potential immunostimulatory and antineoplastics activities. In 2007, AstraZeneca bought MedImmune created in 1988. On Feb 14, 2019, it was announced that MedImmune will cease to exist as an industry name as the owner AstraZenaca has decided to retire the brand as part of ongoing restructuring efforts.https://www.biopharmadive.com/news/astrazeneca-retires-medimmune-name-amid-sales-turnaround/548489/ imgt:mAb_712|imgt:hasProduct|imgt:Product_bfa250a2-4d83-369c-923c-0638ab4c386d imgt:mAb_1267|imgt:inn_number|12234 imgt:Segment_121_1|imgt:has_rank|1 imgt:Construct_356|obo:BFO_0000051|imgt:Segment_356_1 imgt:StudyProduct_337bc546-61ff-3922-a9e1-4aa327357535|rdf:type|obo:NCIT_C174271 imgt:Acute_kidney_transplant_rejection|imgt:isClinicalIndicationOf|imgt:StudyProduct_4ef4b397-36e2-3e59-a016-663f2fbdafd8 imgt:mAb_1261|rdfs:label|mAb_1261 imgt:IL7|rdf:type|imgt:SegmentLabels imgt:TF1|skos:definition|Transferrin-like 1 imgt:V-(DJ)-J-CLUSTER|owl:sameAs|obo:SO_0000519 imgt:mAb_9|imgt:hasMabReceptor|imgt:MAbReceptor_9 imgt:Construct_393|rdf:type|imgt:Construct 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_:B6fbcdd14ff662be46de6db90c0298f23|imgt:isDecisionOf|imgt:StudyProduct_1bceaf82-dddc-3f9d-8b7d-91658f1f9533 imgt:Clone_1280|rdfs:label|Clone_1280 imgt:Product_44a38db4-d2d7-391f-9a70-0d60c3d06106|imgt:commun_name|ALX-0061 imgt:Ceva_Santé_Animale|rdf:type|obo:NCIT_C54131 obo:NCIT_C175749|rdfs:subClassOf|obo:NCIT_C1909 imgt:Construct_1047|rdf:type|imgt:Construct imgt:mAb_1064|imgt:inn_name|melrilimab imgt:StudyProduct_8dcdbc19-94fa-3962-86c1-8bf267c075df|imgt:isStudyProductOf|imgt:Product_d4a38f5a-7adc-3e81-9fb9-4d3d7818a952 imgt:mAb_535|imgt:inn_proposed_list|112 (2014) imgt:Clone_194|imgt:isOriginCloneOf|imgt:mAb_194 imgt:10273|imgt:isImgtStructureEntryOf|imgt:mAb_668 imgt:Product_80d28b5d-927e-3e6c-b0eb-c774baeb327b|imgt:commun_name|RO0503821 imgt:scFv-nd-nd|rdf:type|imgt:ConstructLabels imgt:StudyProduct_6b82f34f-3edd-3161-901d-a48e9eb3c856|imgt:isStudyProductOf|imgt:Product_6700b7b7-e2af-3ee8-873f-cb4f2bdca604 imgt:mAb_1208|imgt:inn_proposed_list|125 (2021) imgt:Segment_830_2|rdf:type|imgt:Segment imgt:11963|rdfs:label|11963 imgt:(DJ)-C-CLUSTER|skos:definition|genomic DNA of an IG or TR locus, in rearranged configuration, including at least one D-J-GENE and one C-GENE imgt:Clone_1202|imgt:isOriginCloneOf|imgt:mAb_1202 imgt:mAb_760|imgt:hasProduct|imgt:Product_a485a257-0ee7-3b5b-836e-05670bd746d8 imgt:IgG1-kappa_644|imgt:isMabReceptorOf|imgt:mAb_644 imgt:mAb_556|imgt:inn_number|10087 imgt:IgG1-kappa_80|rdfs:label|IgG1-kappa_80 imgt:IgM-kappa_193|imgt:hasMolecularComponent|imgt:IG imgt:Product_944016ff-54ec-3384-b70a-18daff0aa3ff|imgt:commun_name|BMS-182248-1 imgt:mAb_1250|rdf:type|obo:NCIT_C1909 imgt:Product_0cc20da1-ae51-3f7b-87ed-d03decfebcf7|imgt:hasStudyProduct|imgt:StudyProduct_d7ff2e98-d0a2-3351-9cd5-54d89f2815bc pubmed:11567989|dc:contributor|Long GD imgt:Systemic_lupus_erythematosus_(SLE)|imgt:isClinicalIndicationOf|imgt:StudyProduct_bc047f4c-b7b7-35d8-b830-4aee2324f3bd imgt:StudyProduct_dcb34807-4868-33f7-b1ca-f367fbeefcbc|imgt:hasClinicalPhase|imgt:Phase_M imgt:Segment_910_1|imgt:has_rank|1 imgt:Clone_237|obo:RO_0002162|imgt:Homsap imgt:Sotio|rdfs:comment|null , null imgt:LRR12|rdf:type|imgt:RepeatLabel imgt:Product_538ab0c9-c52c-3c61-ae4c-1c89532b23a7|rdf:type|obo:NCIT_C51980 imgt:StudyProduct_97df522c-ff88-36a0-be77-ae83c150f1af|imgt:isStudyProductOf|imgt:Product_b9b2acd1-80f6-347f-b121-d8241315bba3 imgt:Neutralisation_activity_of_HSV-1|imgt:isClinicalIndicationOf|imgt:StudyProduct_ad128f55-9f9a-39d6-8b42-149263c92261 imgt:StudyProduct_8b2e4e04-64d3-32a1-9c3e-b0f965cb7b77|imgt:hasExpressionSystem|imgt:_CHO_DXB11 imgt:StudyProduct_cddea082-ad7a-3329-9666-85104cd4f3b2|imgt:hasClinicalIndication|imgt:Cancers_non-small_cell_lung_(NSCLC) imgt:StudyProduct_3365e494-cd15-3232-a8be-a08afe6dced2|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_38beca1b-e357-396b-9768-19337fce60ec|imgt:isStudyProductOf|imgt:Product_a77a82e8-1666-32c6-9125-86cdca4d3f25 imgt:IL31RA|skos:definition|IL31RA (interleukin 31 receptor subunit alpha, interleukin 31 receptor A) imgt:FPIA_%5BPROTEIN%5D2-FC_1293|obo:RO_0002162|imgt:Homsap imgt:Clone_663|obo:RO_0002162|imgt:Ratnor imgt:mAb_863|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=863 imgt:StudyProduct_f5b5f2b6-8fd7-38b9-938b-4f838a392b75|imgt:isStudyProductOf|imgt:Product_3b6c9b0a-cdb1-35e8-a5ba-246fdbd685e6 imgt:StudyProduct_ce7454df-edf4-376d-b09d-99300c553173|rdfs:label|StudyProduct_ce7454df-edf4-376d-b09d-99300c553173 imgt:PDCD1|imgt:isTargetOf|imgt:IgG4-kappa_1142 imgt:9680|rdfs:label|9680 imgt:IgG4-kappa_1187|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG4-kappa.png imgt:Clone_226|imgt:isOriginCloneOf|imgt:mAb_226 imgt:mAb_1005|imgt:imgt_note| datopotamab description is that amended in L123 (2020). imgt:mAb_608|rdf:type|imgt:INN imgt:IG-GAMMA-2-C_LAMBDA|imgt:describes|imgt:IgG2c_Lambda imgt:StudyProduct_c02026b1-5b66-33f2-8d3a-233eb1132402|imgt:hasClinicalIndication|imgt:Diabetic_retinopathy imgt:Construct_18|imgt:hasImgtLabel|imgt:IgG1-nd _:B006945158199dca532098d6d4eaf1361|dc:date|2006-01-01 imgt:Product_dbff9770-a682-338f-b165-d9bc2b235a18|imgt:isProducedBy|imgt:Eli_Lilly imgt:Product_92aaaa11-a012-35e5-91ee-9df570fa89a7|rdfs:label|Product_92aaaa11-a012-35e5-91ee-9df570fa89a7 imgt:FV-ALPHA_BETA|rdf:type|imgt:TREngineeredLabel imgt:_CHOK1SV_(expresses_glutamine_synthetase_(GS)_endogenously)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_29320b6a-0fab-3d74-aa2a-2e745b830dbd imgt:ImmunoGen_Inc|imgt:produces|imgt:Product_10043700-1e80-3056-8d74-e66e9f904bbf imgt:SCFV-KAPPA-HEAVY-SCFV-HEAVY-KAPPA|rdf:type|imgt:IGEngineeredLabel imgt:mAb_281|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=281 imgt:mAb_616|imgt:hasBiosimilar|imgt:pelgraz® imgt:Product_a49e9411-d64f-353e-8cfd-d09ad10a15b3|imgt:commun_name|rsv13/19 imgt:IgM-nd_147|imgt:hasMolecularComponent|imgt:IG imgt:scFv-scFv-scFc_kappa-lambda_1249|obo:RO_0002162|imgt:Hum imgt:MAbReceptor_1166|http://semanticscience.org/resource/SIO_000291|imgt:Globo_H imgt:Fc-Mu|rdfs:label|Fc-Mu imgt:Non-Hodgkin's_lymphoma_(NHL)|imgt:isClinicalIndicationOf|imgt:StudyProduct_e98bf506-f790-37ba-ae2d-fd46eda4a404 imgt:StudyProduct_992fc642-4f83-377b-9e80-da41e1824def|imgt:isStudyProductOf|imgt:Product_e0278568-febe-37ab-bbd2-9027ac7db7e5 imgt:10996|rdfs:label|10996 _:B67d565acc16aaeed9c83d19bf36d8455|imgt:isDecisionOf|imgt:StudyProduct_45967837-7a5b-388a-8270-99c8a7c5d163 imgt:StudyProduct_7a967703-290b-3e04-89fc-4cd1051440a7|imgt:application_type|Therapeutic imgt:Product_0517e477-c651-3706-be63-d3b291cef5f7|imgt:commun_name|AMG-212 imgt:mAb_776|imgt:imgt_note| 6nou is the 3D structure of the scFv anti-IL17A derived from the ixekizumab VH and VL (IMGT/mAb-DB ID: #380 , IMGT/3Dstructure-DB: Fab 6nov ), linked with a 25-mer linker and stabilized by a disulfide bridge (VH G49C, V-KAPPA Q120C).The amino acid sequence of the 3D 6nou stabilized scFv and that of each of the scFv fused to the heavy chains in tibulizumab (IMGT/2Dstructure-DB: 10656 ) differ by VH S29K (491) and M59T (517), V-KAPPA N35E (637) and by the linkers (25-mer and 16-mer, respectively). IgG4 - kappa is identical in 9430 (tabalumab) and 10656 (tibulizumab). imgt:mAb_1181|rdf:type|obo:NCIT_C1909 imgt:mAb_594|imgt:hasImgtStructureEntry|imgt:10195 imgt:StudyProduct_6586edfa-dd5f-32c0-bbb9-6c7d64dc0480|imgt:application_type|Therapeutic imgt:Clone_1244|imgt:clone_name|ZTS-00521426-C71 imgt:Bristol-Myers_Squibb|imgt:produces|imgt:Product_6b7288a6-6029-31fb-b656-98758dba3c92 imgt:isClusterOf|skos:definition|inverse of isInCluster imgt:8651|rdf:type|obo:NCIT_C25402 imgt:StudyProduct_c1c79f94-82b3-3634-af44-93c5fd798a7d|imgt:hasClinicalIndication|imgt:Gram-negative_sepsis imgt:Construct_233|obo:BFO_0000051|imgt:Segment_233_1 imgt:Roche_F_Hoffmann-La_Roche_Ltd|imgt:produces|imgt:Product_bf86896a-6e07-3197-9ec5-528592683dd0 imgt:ENZ-CTP_698|imgt:isMabReceptorOf|imgt:mAb_698 _:B58b07bc4f64201d065d0bedce845fa5d|dc:date|2018-12-18 imgt:Solid_organ_transplantation|imgt:isClinicalIndicationOf|imgt:StudyProduct_90360979-47fa-3ad6-ab83-9143ad9b06be imgt:Construct_252|obo:BFO_0000051|imgt:Segment_252_1 imgt:mAb_682|imgt:hasProduct|imgt:Product_4cf2f354-03b0-3649-acb9-df3628a4e9e8 imgt:StudyProduct_23e6cb85-b1f6-376c-a384-fd55c313f434|imgt:application_type|Therapeutic imgt:mAb_893|rdfs:label|mAb_893 imgt:mAb_727|imgt:hasImgtStructureEntry|imgt:10536 imgt:Product_d5331edb-b52e-3dc3-99e7-61c04420b4bb|imgt:comercial_name|BLINCYTO® imgt:FOLH1|imgt:isTargetOf|imgt:IgG1-kappa_MM_115 imgt:Product_87376b34-c995-367f-9c8c-6b74e4f5097b|imgt:commun_name|Leukotuximab imgt:StudyProduct_53334127-51ec-3e46-bb66-71919e3cce29|rdf:type|obo:NCIT_C174271 imgt:Product_e5ca6245-7a11-3390-b7de-6b5e8870b2ab|imgt:hasStudyProduct|imgt:StudyProduct_0bf6eb3e-ae1f-3211-b64b-2e4f87af2cee imgt:FPIA_%5BPROTEIN_VLIKE%5D2-FC_212|http://semanticscience.org/resource/SIO_000291|imgt:CD80 imgt:mAb_1259|imgt:inn_proposed_list|126 (2022) imgt:mAb_481|rdf:type|obo:NCIT_C174737 imgt:CCL11|rdf:type|obo:NCIT_C25702 imgt:Product_e521e71e-0d27-3157-a807-f8780c379245|imgt:hasStudyProduct|imgt:StudyProduct_1ee2b67f-f28b-3127-9a26-1511efd39fc8 imgt:mAb_1074|imgt:hasImgtStructureEntry|imgt:11421 imgt:Product_8b707060-aa4c-3416-b720-0b2304c54b88|imgt:commun_name|MEDI4736 imgt:mAb_519|imgt:clinical_trials|3 studies found, 1 recruiting imgt:9447|rdf:type|obo:NCIT_C25402 imgt:DomainLabel|skos:definition| imgt:Clone_25|rdf:type|obo:NCIT_C37925 imgt:StudyProduct_57c2c1f6-5dab-34a3-8834-04a257252f25|rdf:type|obo:NCIT_C174271 imgt:Segment_283_1|rdfs:label|Segment_283_1 imgt:OtherLabel|rdf:type|owl:Class imgt:StudyProduct_1bd1f357-adce-3f38-b965-daef051d4331|imgt:isStudyProductOf|imgt:Product_010eb41e-d503-390b-825c-4077f0fe83bd imgt:Cancers_colorectal_(CRC)|imgt:isClinicalIndicationOf|imgt:StudyProduct_2a62a5a2-fcbd-3027-9355-dd832fc35623 imgt:Construct_711|obo:BFO_0000051|imgt:Segment_711_1 pubmed:17240489|dc:contributor|Sloan SE imgt:StudyProduct_8520474f-a705-3f52-b54e-4a6a92032f13|imgt:hasClinicalPhase|imgt:Phase_I/II imgt:equidacent™|imgt:isBiosimilarOf|imgt:mAb_24 imgt:StudyProduct_cff2ed84-8d7a-3c61-9a87-baf0ef1d3d9c|imgt:development_technology| Alternative to antigen receptors domain scaffold THB, three helical bundle (Affibody®) imgt:StudyProduct_5e71b1dd-9ab2-3249-a5d9-508cd9d5ced1|rdf:type|obo:NCIT_C174271 imgt:PROTEIN_1DOMAIN_983|obo:RO_0002162|imgt:Homsap imgt:Segment_853_1|imgt:has_rank|1 imgt:mAb_716|imgt:imgt_note| suvratoxumab prevents the binding of Staphylococcus aureus alpha-toxin (AT) to its cellular receptor ADAM metalloproteinase domain 10 (ADAM10, CD156c). It is developed for the prevention of nocosomial pneumonia caused by Staphylococcus aureus. In 2007, AstraZeneca bought MedImmune created in 1988. On Feb 14, 2019, it was announced that MedImmune will cease to exist as an industry name as the owner AstraZenaca has decided to retire the brand as part of ongoing restructuring efforts.https://www.biopharmadive.com/news/astrazeneca-retires-medimmune-name-amid-sales-turnaround/548489/ imgt:Segment_82_1|imgt:hasImgtLabel|imgt:CD4 imgt:IgG1-nd_26|imgt:hasConstruct|imgt:Construct_26 imgt:StudyProduct_ae27ebd6-88cf-3350-b271-abd3ff3d5bc5|imgt:hasClinicalPhase|imgt:Phase_I imgt:mAb_1085|imgt:inn_name|izuralimab imgt:Clone_264|rdf:type|obo:NCIT_C37925 imgt:Product_64d31d25-899a-3941-a5d0-bc3b3c0b468b|imgt:commun_name|RO-7187807 obo:NCIT_C66982|rdfs:subClassOf|obo:NCIT_C1909 imgt:Segment_482_1|imgt:has_rank|1 imgt:IgG1-kappa_1143|http://semanticscience.org/resource/SIO_000291|imgt:bispecific imgt:Roche_F_Hoffmann-La_Roche_Ltd|imgt:produces|imgt:Product_2b62ff3b-5777-30b1-8021-af790e255f4e imgt:mAb_455|rdf:type|imgt:INN imgt:MAbReceptor_509|rdfs:label|MAbReceptor_509 _:B5c9a44e3974168f59d373ba03bb9b9dc|dc:date|2020-08-08 pubmed:1367535|dc:contributor|Taylor G. imgt:II-BETA|rdfs:label|II-BETA imgt:CALCB|rdfs:label|CALCB imgt:Product_ac4bd0ed-460f-34fb-8dc2-a259a562ee2f|imgt:isProductOf|imgt:mAb_124 imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_15335a0b-21d4-30ab-baca-3f098f84411e imgt:StudyProduct_036cdd39-9d78-3853-b645-e48ae3d4b24e|imgt:application_type|Therapeutic imgt:Product_6a9aeddf-c689-31d0-a3b9-ccc3ab651bc5|imgt:hasStudyProduct|imgt:StudyProduct_3b49444b-27d5-3009-9948-320cd9518ba7 imgt:StudyProduct_eb3b48a7-f6ff-3115-9280-0baaaddd2d9d|imgt:hasClinicalIndication|imgt:Hematologic_malignancies imgt:Segment_308_1|imgt:hasImgtLabel|imgt:IgG3-kappa imgt:V-J-C-chain|skos:definition|Identifies, for protein, molecule entities without a leader L region (mature form) and with a rearranged V region, a rearranged J region and a C region in undefined configuration. V-J-C-chain is in rearranged configuration. imgt:Psoriasis|imgt:isClinicalIndicationOf|imgt:StudyProduct_975e1353-8fe5-30e5-bb01-d75eb6760ec9 imgt:mAb_1285|rdfs:label|mAb_1285 imgt:mAb_429|imgt:inn_name|placulumab imgt:mAb_595|imgt:hasMabReceptor|imgt:IgG4-kappa_595 imgt:Segment_1110_1|obo:BFO_0000050|imgt:Construct_1110 imgt:Product_0e71815e-bc5c-3088-87f0-5fb9ca2d7a89|rdf:type|obo:NCIT_C51980 imgt:IgG1-kappa_1004|imgt:hasMolecularComponent|imgt:IG imgt:Product_032579b1-dca3-3eba-bb14-e6a77024cc1e|imgt:isProducedBy|imgt:ImmunoGen_Inc imgt:Construct_464|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Product_73c8f272-2743-3eb0-8838-5a74f2a6d142|imgt:commun_name|Ab-2 imgt:Segment_1115_1|rdfs:label|Segment_1115_1 imgt:Product_1d32d5b1-99c8-31ab-9a21-acfa4c132ab7|imgt:comercial_name|Lymphoscan® imgt:mAb_465|imgt:hasMabReceptor|imgt:IgG1-lambda_465 imgt:IgG1-kappa_861|obo:RO_0002162|imgt:Chi imgt:StudyProduct_e89204d0-5272-3622-a141-6a7837612b20|imgt:application_type|Therapeutic imgt:Roche_F_Hoffmann-La_Roche_Ltd|imgt:produces|imgt:Product_1e3cda94-2406-3561-8738-08bd95e9c60b imgt:Product_43770def-58de-3eca-8895-b84dbe04fcfa|imgt:hasStudyProduct|imgt:StudyProduct_4cfdf2ec-f342-3054-9bde-f57fcde70b5d imgt:StudyProduct_f95e7e1c-4453-3bfe-835c-1245dfb30b90|rdfs:label|StudyProduct_f95e7e1c-4453-3bfe-835c-1245dfb30b90 imgt:Glycotope_GmbH|imgt:produces|imgt:Product_4e3ee393-6309-3c6c-8d2a-20909237db73 obo:NCIT_C166910|rdf:type|owl:Class imgt:Segment_1150_1|rdfs:label|Segment_1150_1 _:B6f1875750fae388d10d018cf30add41d|imgt:isDecidedBy|imgt:FDA imgt:Product_1aaa2a7e-6eb9-3729-a3c8-9ebd6913b871|rdf:type|obo:NCIT_C51980 obo:NCIT_C71009|rdf:type|owl:Class imgt:mAb_643|rdf:type|imgt:INN imgt:mAb_795|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=795 imgt:StudyProduct_d147df3d-6f40-37d7-8fd3-247e6dcd509d|rdf:type|obo:NCIT_C174271 imgt:IGHE|imgt:isTargetOf|imgt:IgG1-kappa_422 imgt:Clone_572|imgt:clone_name|IIIA4 anti-EphA3 imgt:Segment_529_1|rdf:type|imgt:Segment imgt:StudyProduct_f74c0406-a8cf-360b-a0e5-687f8ccd98cd|imgt:development_technology| glutamine synthethase GS Gene Expression System™ imgt:IgG1-kappa_803|imgt:hasConstruct|imgt:Construct_803 obo:NCIT_C130010|rdf:type|owl:Class imgt:Product_90b985a1-c752-3673-801f-841c91bb6278|imgt:isProducedBy|imgt:Affitech imgt:mAb_596|imgt:inn_name|rivabazumab obo:NCIT_C175778|rdfs:subClassOf|obo:NCIT_C1909 imgt:mAb_696|rdf:type|obo:NCIT_C169865 imgt:Segment_1270_1|rdfs:label|Segment_1270_1 imgt:Product_c4204b43-73aa-38da-ac5f-ba2422e984ab|imgt:isProducedBy|imgt:Sanofi _:B1c27eff33108724b257e02e5cd054d6d|rdf:type|obo:NCIT_C53285 imgt:Alzheimer's_disease_(AD)|imgt:isClinicalIndicationOf|imgt:StudyProduct_baa41ac1-2853-3eba-ae43-e487b5c0b4c0 imgt:Lees_Pharmaceutical|rdf:type|obo:NCIT_C54131 imgt:mAb_1251|imgt:inn_name|fiztasovimab obo:NCIT_C84217|rdf:type|owl:Class imgt:Product_4b923003-44a0-305e-869a-41e26bddedbb|rdf:type|obo:NCIT_C51980 imgt:Acute_myeloid_leukemia_(AML)|imgt:isClinicalIndicationOf|imgt:StudyProduct_c0c3e436-3c22-3968-a5d0-efc387b4d777 imgt:9861|rdfs:label|9861 imgt:BETA-ALPHA1_1041|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/BETA-ALPHA1.png imgt:mAb_490|imgt:hasMabReceptor|imgt:IgG1-kappa-4lys-drug_490 imgt:Myasthenia_gravis_(MG)|imgt:isClinicalIndicationOf|imgt:StudyProduct_db1013df-4506-3dee-b7a7-2438a73f2465 imgt:Product_087106c8-1d20-3672-9d32-bc8b102b16ae|imgt:isProductOf|imgt:mAb_32 imgt:StudyProduct_ec304d9a-2c0c-33e1-b37b-df7ea6c79222|rdfs:label|StudyProduct_ec304d9a-2c0c-33e1-b37b-df7ea6c79222 imgt:mAb_456|imgt:imgt_note| Morphosys HuCAL® (Human combinatorial Antibody library) phage display library Aug 20, 2013 FDA breakthrough therapy designation for sporadic inclusion body myositis (sIBM) bimagrumab INN definition is the one amended in L110 (2013) and in R70 (2013). imgt:RPI-Subgroup|rdfs:subClassOf|imgt:Subgroup imgt:mAb_1155|imgt:inn_proposed_list|124 (2020) imgt:StudyProduct_72ff4f54-c4c9-36ac-aee8-60575d89dda8|imgt:application_type|Therapeutic imgt:StudyProduct_f9fba47d-6ea7-3ed9-ac16-97112b9c2224|imgt:hasClinicalIndication|imgt:Crohn's_disease_(CD) imgt:IgG1-kappa-2cys-drug_774|imgt:via_a| cleavable maleimidocaproyl-valyl-citrullinyl-p-aminobenzyloxycarbonyl (mc-val-cit-PABC) type linker imgt:StudyProduct_205fae1d-bebf-35b0-8d3f-36902092b1c1|imgt:hasClinicalIndication|imgt:Lymphoma_diffuse_large_B_cell_(DLBCL) _:B1f9064a8a40f017c8da5b4e23906b3de|dc:date|2013-06-28 imgt:mAb_136|rdfs:label|mAb_136 obo:NCIT_C106118|rdfs:subClassOf|obo:NCIT_C1909 imgt:fibrin-binding_surface_epitope_clumping_factor_A|rdf:type|obo:NCIT_C25702 imgt:Product_0dc35379-efa3-32cf-93ef-6c88dcbb0baf|rdf:type|obo:NCIT_C51980 imgt:Severe_acute_respiratory_syndrome_coronavirus_2_(SARS-CoV-2)|obo:RO_0002162|imgt:Humcor imgt:IgG1-kappa_812|imgt:isMabReceptorOf|imgt:mAb_812 imgt:IgG1-kappa-4cys-drug_571|rdf:type|imgt:MAbReceptor 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imgt:mAb_997|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=997 imgt:StudyProduct_3e64b023-44c7-39c1-bd6a-db6275fc93ef|rdfs:label|StudyProduct_3e64b023-44c7-39c1-bd6a-db6275fc93ef imgt:LRR1|rdf:type|imgt:RepeatLabel imgt:Product_b0734cf2-486f-3853-a05a-854676784ad9|imgt:hasStudyProduct|imgt:StudyProduct_d7b1b25d-3c9f-3e58-bff5-5644fbebb845 imgt:Biogen_Inc|imgt:produces|imgt:Product_37d8c4e2-9f50-3ca5-bcfe-d2357ba209e5 imgt:Segment_1228_3|obo:BFO_0000050|imgt:Construct_1228 pubmed:9099717|dc:title|Antibody humanization using monovalent phage display. imgt:Segment_253_1|obo:BFO_0000050|imgt:Construct_253 imgt:Product_fa1611a1-d429-3eb4-b062-4987c35cddde|rdf:type|obo:NCIT_C51980 imgt:Product_b7a7e4bb-f8f0-300e-9c56-2377c788b72a|imgt:isProductOf|imgt:mAb_225 imgt:StudyProduct_0d0b843e-ae7e-3ec1-8787-5451392da30d|rdfs:label|StudyProduct_0d0b843e-ae7e-3ec1-8787-5451392da30d obo:NCIT_C114500|rdf:type|owl:Class imgt:Segment_18_1|imgt:has_rank|1 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imgt:1AE6|imgt:isImgtStructureEntryOf|imgt:mAb_508 imgt:scFv-kappa-heavy-TOXIN_BIG_237|rdfs:comment|scFv-kappa-heavy-TOXIN_BIG imgt:Construct_1276|rdf:type|imgt:Construct imgt:mAb_300|imgt:hasProduct|imgt:Product_483963c5-2edc-3412-9648-699e6b83a759 imgt:StudyProduct_98533fcd-e194-327a-8789-8909fce031a5|imgt:hasClinicalIndication|imgt:Solid_tumors imgt:4TNFR-CYS|rdfs:label|4TNFR-CYS imgt:IgG2-kappa_230|rdfs:comment|IgG2 - kappa imgt:Clone_963|imgt:isOriginCloneOf|imgt:mAb_963 imgt:mAb_131|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=131 imgt:mAb_1022|imgt:hasMabReceptor|imgt:IgG1-lambda_1022 pubmed:7608568|dc:contributor|Ellis J.H. imgt:IgG4-kappa_75|rdfs:label|IgG4-kappa_75 imgt:StudyProduct_da550ada-9aaa-3da4-a461-f434dc605d65|imgt:development_technology| Dual-Affinity Re-targenting (DART®) imgt:mAb_1214|imgt:inn_proposed_list|125 (2021) imgt:mAb_374|imgt:hasMabReceptor|imgt:IgG1-kappa_374 _:B5a45b170f0ed0a178bf18d3af3ffa4c9|imgt:isDecidedBy|imgt:FDA 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imgt:StudyProduct_521bdb6c-241f-3c8b-83bf-6f87a696275a|imgt:isStudyProductOf|imgt:Product_7223271e-99bc-3aad-b1dc-917ee78af247 imgt:CPCA_three-helical_bundle_1046|http://semanticscience.org/resource/SIO_000291|imgt:ALB imgt:StudyProduct_61dc3c81-aee9-350f-8e30-60af5dc8b9a2|imgt:hasClinicalIndication|imgt:Cancers_non-small_cell_lung_(NSCLC) imgt:Construct_426|rdfs:label|Construct_426 imgt:IgG1-kappa_887|http://semanticscience.org/resource/SIO_000291|imgt:IL6R imgt:mAb_563|imgt:inn_proposed_list|113 (2015) imgt:mAb_1012|imgt:hasProduct|imgt:Product_a838a466-6e78-37f8-8180-fe9953f25670 imgt:StudyProduct_67953f78-4ea2-395b-9a44-816e983f7798|rdfs:label|StudyProduct_67953f78-4ea2-395b-9a44-816e983f7798 imgt:IgG1-kappa_566|obo:RO_0002162|imgt:Hum imgt:StudyProduct_d1accc69-7ed8-3ef7-b9f6-a21126422aa9|rdfs:label|StudyProduct_d1accc69-7ed8-3ef7-b9f6-a21126422aa9 imgt:hasBiosimilar|rdfs:range|obo:NCIT_C156644 imgt:Clone_1236|obo:RO_0002162|imgt:Homsap imgt:StudyProduct_6d193eb7-5b97-3179-b1b3-93367812fe58|imgt:hasClinicalPhase|imgt:Phase_I imgt:StudyProduct_924e9446-ea3e-3428-b541-c85cae529bfd|imgt:hasDecision|_:B16b288eb459887927e90d17d0991607d imgt:mAb_615|rdf:type|obo:NCIT_C1909 imgt:%5BPEP%5D15|rdf:type|imgt:ChainLabels imgt:Product_548e85bb-73f0-3eda-a78b-8134d0e04416|imgt:commun_name|RO5541077-000 imgt:Construct_1261|obo:BFO_0000051|imgt:Segment_1261_1 imgt:IL4|rdfs:label|IL4 imgt:Segment_274_1|imgt:has_rank|1 imgt:StudyProduct_43cc644c-72e4-3a37-9bc5-aaadba950e4d|rdfs:label|StudyProduct_43cc644c-72e4-3a37-9bc5-aaadba950e4d imgt:PVRL4|imgt:isTargetOf|imgt:IgG1-kappa-4cys-drug_476 imgt:StudyProduct_6e1d6f70-6543-3bce-a73d-eacbc56df1a3|imgt:application_type|Therapeutic imgt:9476|rdf:type|obo:NCIT_C25402 imgt:mAb_738|imgt:inn_name|tomuzotuximab obo:NCIT_C120309|rdfs:subClassOf|obo:NCIT_C1909 imgt:StudyProduct_f29636cb-fd68-3398-8fdc-2b599d7c9326|rdf:type|obo:NCIT_C174271 imgt:Construct_400|rdf:type|imgt:Construct imgt:mAb_140|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=140 imgt:StudyProduct_bc9039b6-a991-3026-9681-be607e9c780f|imgt:isStudyProductOf|imgt:Product_05e00a74-7ade-3620-baac-283a328b8f7c imgt:StudyProduct_5707ebaf-6481-3026-aa43-7296288f0f4e|rdfs:label|StudyProduct_5707ebaf-6481-3026-aa43-7296288f0f4e imgt:Millennium_Pharmaceuticals_Inc|imgt:produces|imgt:Product_472580a9-a9b7-36d2-8b15-c38c1bd71e1f imgt:IgA1_Lambda|rdf:type|imgt:ReceptorType imgt:mAb_1008|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=1008 pubmed:21330330|dc:contributor|Morra E imgt:mAb_536|rdf:type|obo:NCIT_C169818 imgt:IgM-nd_191|rdfs:label|IgM-nd_191 imgt:Non-Hodgkin's_lymphoma_(NHL)|imgt:isClinicalIndicationOf|imgt:StudyProduct_e1f9adf1-1e31-39fb-a366-accd099ef99a imgt:StudyProduct_c9cc77d2-0fb1-39bb-b402-6ab0a088f853|rdf:type|obo:NCIT_C174271 imgt:Lonza_Biologics|rdf:type|obo:NCIT_C54131 _:B9733a650011d5bf4b18c314e13de94bd|imgt:hasStatut|imgt:approval imgt:mAb_1016|imgt:inn_number|11194 imgt:StudyProduct_4ae01645-c1e9-38af-86e6-d49652281689|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:Product_bd0c88b6-9625-38c8-87d1-1890eee03a40|rdfs:label|Product_bd0c88b6-9625-38c8-87d1-1890eee03a40 _:B1ddd0d71713c8a0a71446e2e2ebc070d|rdf:type|obo:NCIT_C53285 imgt:Cancers_fallopian_tube|rdfs:label|Cancers_fallopian_tube imgt:interleukin|rdf:type|owl:Class imgt:StudyProduct_b99c5ced-585d-3c4f-8398-9f413b697d87|rdf:type|obo:NCIT_C174271 imgt:Product_e33b9fa9-607c-3ad6-9067-67e1a56774e5|rdfs:label|Product_e33b9fa9-607c-3ad6-9067-67e1a56774e5 imgt:IgG1-nd_26|obo:RO_0002162|imgt:Hum imgt:CONNECTING-REGION|rdfs:label|CONNECTING-REGION _:Bc4bc2a15f227f8bb7e7f2b94c5b3a4f0|rdf:type|obo:NCIT_C53285 obo:NCIT_C87767|rdfs:subClassOf|obo:NCIT_C1909 imgt:Weill_Cornell_Medical|imgt:produces|imgt:Product_23bdc528-2f16-3a86-9e4c-0033da4742f2 imgt:mAb_35|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=35 imgt:Product_cfe7feb8-af89-32b0-b422-e41ff6ece0e5|rdf:type|obo:NCIT_C51980 imgt:Construct_190|obo:BFO_0000051|imgt:Segment_190_1 imgt:IgG1-lambda_157|http://semanticscience.org/resource/SIO_000291|imgt:CD4 imgt:StudyProduct_a3b055d6-b079-3da5-982f-b3d60dd4efd4|rdfs:label|StudyProduct_a3b055d6-b079-3da5-982f-b3d60dd4efd4 imgt:mAb_1217|imgt:hasMabReceptor|imgt:IgG1-kappa_1217 imgt:Product_0627b44a-53c2-39b9-93d4-afa1b06b8a7d|imgt:hasStudyProduct|imgt:StudyProduct_dfbc65ae-8aec-31ce-b75e-aa1c7eb2bcfc imgt:Product_557d6f3c-8aa3-35e6-bb7d-6df5196f42e8|imgt:hasStudyProduct|imgt:StudyProduct_62eabf4d-dc27-3797-992c-83383d2d31b6 imgt:Product_71f993b9-6775-3d87-aa0f-a0d81ddc4f3c|imgt:isProducedBy|imgt:Genentech_Inc imgt:rixathon®/riximyo®|rdfs:comment| RIXATHON®/RIXIMYO® (rituximab GP2013) developed by Sandoz Inc. (Wilson NC USA) approved in the EU by EC on June 19 2017. Same clinical indications as MABTHERA®. imgt:Product_6be191cd-f8da-3267-8190-2deedbc9ec49|rdf:type|obo:NCIT_C51980 imgt:_CHOK1SV_(lacking_the_glutamine_synthetase_(GS)_gene)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_62b19c3b-0d97-3d27-8656-3da0e9319915 imgt:Product_d3b1c87b-c5d7-3da1-8427-6001eddc9b90|imgt:hasStudyProduct|imgt:StudyProduct_bfa3a1bc-fc7c-368a-bff0-d8cb611a8fbf imgt:mAb_404|rdf:type|obo:NCIT_C152246 imgt:10459|rdf:type|obo:NCIT_C25402 imgt:ITGB2|rdfs:label|ITGB2 imgt:Product_565b4b15-341c-3c05-a51b-4245fd8756f8|rdfs:label|Product_565b4b15-341c-3c05-a51b-4245fd8756f8 imgt:Product_79c48f1c-e47e-37e0-a142-44132cbf3ead|rdf:type|obo:NCIT_C51980 imgt:Cancers_colorectal_(CRC)_metastatic|imgt:isClinicalIndicationOf|imgt:StudyProduct_798de131-ed3d-32b5-98df-955db52f62c0 imgt:Construct_673|obo:BFO_0000051|imgt:Segment_673_1 imgt:StudyProduct_4782b1c1-f2ea-311e-ba07-ac9afd5f009b|rdfs:label|StudyProduct_4782b1c1-f2ea-311e-ba07-ac9afd5f009b imgt:Product_5021057f-cae7-3bd7-9a40-1a3c99bf3ca5|imgt:isProductOf|imgt:mAb_867 _:B6fbcdd14ff662be46de6db90c0298f23|imgt:hasStatut|imgt:approval imgt:mAb_190|imgt:hasOriginClone|imgt:Clone_190 imgt:ICAM1|imgt:isTargetOf|imgt:MAbReceptor_317 imgt:StudyProduct_2b299490-c54a-39a2-b2a2-8f33b6b1603b|rdfs:label|StudyProduct_2b299490-c54a-39a2-b2a2-8f33b6b1603b imgt:IgG1-kappa_728|obo:RO_0002162|imgt:Chi imgt:StudyProduct_026b75f7-c995-3045-a2f6-daa0a331f298|imgt:hasClinicalPhase|imgt:Phase_I imgt:IgG1-kappa_806|imgt:isMabReceptorOf|imgt:mAb_806 imgt:mAb_81|rdf:type|obo:NCIT_C95792 imgt:Product_00bacc20-6ab0-3330-acf7-f6cdf2e390a8|rdf:type|obo:NCIT_C51980 imgt:Antithrombotic|imgt:clinical_domain|Hematology imgt:StudyProduct_18ad78ee-c246-3c4f-addd-a08cecc8490f|imgt:isStudyProductOf|imgt:Product_11743f52-8d52-3e88-b8df-04e83be3502a imgt:9053|rdf:type|obo:NCIT_C25402 imgt:Alpine_Immune_Sciences|imgt:produces|imgt:Product_c7be9dd8-8b8f-38bc-9841-af5bf6b87cd0 imgt:StudyProduct_151b8421-560f-3a04-9445-3ac5bd3c9d3a|rdf:type|obo:NCIT_C174271 imgt:IgG1-V-lambda-C-kappa_856|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-V-lambda-C-kappa.png imgt:Factor_VII_deficiency_(treatment_of_bleeding_episodes)|imgt:isClinicalIndicationOf|imgt:StudyProduct_636146a7-faa7-30f7-9b23-dd784755dacc imgt:mAb_261|imgt:hasMabReceptor|imgt:IgG1-kappa_261 imgt:mAb_701|imgt:hasProduct|imgt:Product_18e218fa-ac0d-39a4-9e01-9513fbb2bc7c imgt:IgG4-nd_256|imgt:hasMolecularComponent|imgt:IG imgt:mAb_801|imgt:hasProduct|imgt:Product_62af0e26-0c78-3679-b620-0dd8fc831ab4 imgt:Product_c299e202-690b-3ffc-8c53-e45056548ad0|imgt:hasStudyProduct|imgt:StudyProduct_7085856d-d0c1-3411-960f-754ecb2ea0dd imgt:Segment_771_1|rdfs:label|Segment_771_1 imgt:FAB-GAMMA-1_LAMBDA|rdf:type|imgt:IGProteolyticFragmentLabel imgt:Product_42e77b63-637a-3381-a8be-5f8318cc28a2|imgt:commun_name|Peg-IFNA2 R23 imgt:INTEGRIN-BETA-3|rdfs:label|INTEGRIN-BETA-3 imgt:Tn3-ALB_1117|imgt:hasMolecularComponent|imgt:CPCA imgt:Malignant_ascites|imgt:isClinicalIndicationOf|imgt:StudyProduct_0485cef8-ac82-346b-aa36-ae9f4bdb7da9 imgt:mAb_1050|imgt:inn_proposed_list|122 (2019) imgt:IgG1-kappa_76|http://semanticscience.org/resource/SIO_000291|imgt:EGFR imgt:IgG1-lambda_800|imgt:hasMolecularComponent|imgt:IG imgt:%5BAXL_(AXL_receptor_tyrosine_kinase_ARK_JTK11_Tyro7_UFO)%5D2-IGHG1_Fc_(Fragment_constant)|rdfs:label|[AXL (AXL receptor tyrosine kinase, ARK, JTK11, Tyro7, UFO)]2 - IGHG1 Fc (Fragment constant) _:Be9f52a87b98f99457a00ed45741ec109|dc:date|2013-01-01 imgt:Product_e43a8019-eea8-307e-b67c-b0bd073d0380|imgt:isProductOf|imgt:mAb_374 imgt:mAb_560|imgt:inn_name|clivatuzumab tetraxetan imgt:mAb_528|imgt:inn_proposed_list|112 (2014) imgt:StudyProduct_e189c556-df4c-3e83-8fbb-71a91cb759a8|imgt:hasClinicalPhase|imgt:Phase_I imgt:IgG1-kappa_417|obo:RO_0002162|imgt:Homsap imgt:mAb_1187|imgt:hasMabReceptor|imgt:IgG4-kappa_1187 imgt:StudyProduct_44f02f71-fa31-3d0d-b5d3-9435a6d250ed|imgt:hasDecision|_:Bc2c140e850dedbf8569745f0a5f3462b imgt:Clone_1209|imgt:clone_name|8C11-62A12 imgt:Segment_756_1|obo:BFO_0000050|imgt:Construct_756 imgt:StudyProduct_dd280ef2-2788-362e-80c5-4f8e384785f3|imgt:hasClinicalIndication|imgt:Schnitzler_syndrome obo:NCIT_C95321|rdfs:subClassOf|obo:NCIT_C1909 imgt:StudyProduct_85a32e89-e3eb-363b-9c38-0364c0442362|rdfs:label|StudyProduct_85a32e89-e3eb-363b-9c38-0364c0442362 _:B690ba0ce00923397d0089d050118b36c|rdf:type|obo:NCIT_C53285 _:Be58e4ac46e8500a4a21617bdfbc817f8|dc:date|2020-06-16 imgt:Adult_eosinophilic_asthma|imgt:isClinicalIndicationOf|imgt:StudyProduct_d0ef6cb1-edf4-3df0-930b-7ea881c98a95 imgt:IgG1-kappa_MM_126|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa_MM.png imgt:Segment_333_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Product_6317cbca-eed3-3c33-9a06-07efb4c70202|imgt:commun_name|ABBV-176 imgt:Construct_969|imgt:isConstructOf|imgt:IgG4-kappa_969 imgt:Construct_492|rdf:type|imgt:Construct imgt:Segment_1180_1|imgt:hasImgtLabel|imgt:IgG4-kappa _:Bdff7d1f3ae521a8651c54020f3ecaa27|imgt:isDecisionOf|imgt:StudyProduct_ba0c4175-6d0a-3397-888e-10055e790391 imgt:mAb_1096|rdfs:label|mAb_1096 imgt:IgG1-kappa_662|rdfs:comment|IgG1 - kappa imgt:mAb_212|imgt:inn_name|abatacept imgt:Construct_1080|rdfs:label|Construct_1080 imgt:StudyProduct_dd88f5dd-8d77-3766-9219-118b017a5fe6|imgt:hasClinicalPhase|imgt:Phase_III imgt:FAB-GAMMA-4_KAPPA|imgt:describes|imgt:Fab-Gamma-4_Kappa imgt:mAb_753|imgt:clinical_trials|10 studies found, 4 recruiting imgt:10232|imgt:isImgtStructureEntryOf|imgt:mAb_867 _:Baab72f87c3e1d8847dbaf16dd0b13cf6|rdf:type|obo:NCIT_C53285 imgt:PRLR|skos:definition|PRLR (prolactin receptor) imgt:IFNAR2|imgt:isTargetOf|imgt:PROTEIN_1DOMAIN-PEG_628 obo:NCIT_C174583|rdf:type|owl:Class imgt:IgG2-kappa_597|rdf:type|imgt:MAbReceptor imgt:CSF2_(colony_stimulating_factor_2_(granulocyte-macrophage)_granulocyte-macrophage_colony_stimulating_factor_GM-CSF)_recombinant|rdfs:label|CSF2 (colony stimulating factor 2 (granulocyte-macrophage), granulocyte-macrophage colony stimulating factor, GM-CSF) recombinant _:B32c1cefbfe23c4d2bdfd9ef9fc657023|rdf:type|obo:NCIT_C53285 imgt:CD8A|rdfs:label|CD8A imgt:IgG1-kappa_1181|http://semanticscience.org/resource/SIO_000291|imgt:CD40 _:B444815c10574dfb4e52c879d6f2375a4|imgt:isDecidedBy|imgt:FDA _:B7ce5a20d1ce487a7f39573322299139b|imgt:hasDesignation|imgt:Orphan_drug imgt:Product_d3c2662f-9244-388c-aa91-aa125c885265|rdf:type|obo:NCIT_C51980 imgt:(scFv-heavy-kappa)-(scFv-heavy-lambda)_498|rdfs:comment|(scFv - heavy - kappa) - (scFv - heavy - lambda) imgt:Segment_674_1|obo:BFO_0000050|imgt:Construct_674 imgt:Product_93206283-82d3-36e4-9d0c-3c11439967eb|imgt:hasStudyProduct|imgt:StudyProduct_c2507d13-5072-352d-a3f4-c24fbcd25830 imgt:isDescribedBy|owl:inverseOf|imgt:describes pubmed:16697465|imgt:isBibliographicReferenceOf|imgt:mAb_367 imgt:StudyProduct_b7b4c1db-df22-3f75-96fc-bfdd0e484d13|imgt:hasDecision|_:Bcd70d974eb472dfdc532894476b56451 imgt:Segment_611_1|imgt:has_rank|1 imgt:Segment_1298_2|imgt:segment_detail|Fc (Fragment constant) _:B07b3bafaad95066d34ffc255ab34fc82|imgt:isDecidedBy|imgt:FDA imgt:Product_116668fd-8e29-3f7a-bcf8-aed5bb915412|imgt:isProducedBy|imgt:Regeneron_Pharmaceuticals_Inc imgt:Segment_991_1|imgt:hasImgtLabel|imgt:IgG2b-kappa imgt:Merck_&_Co_Inc|imgt:produces|imgt:Product_c4b5a4f9-01ee-3823-90ef-f047993fe32e _:B387a5e064bf3fc8f28e9d687036e254a|dc:date|1993-07-23 imgt:StudyProduct_2314246e-4d62-3512-9c45-8393eff5d5e5|imgt:hasClinicalIndication|imgt:IgG4-related_disease_(IgG4-RD) imgt:IgG4-kappa_170|rdfs:comment|IgG4 - kappa imgt:Product_23845aab-eacf-316c-b614-80fa65b8d2cd|imgt:hasStudyProduct|imgt:StudyProduct_b0c9b53b-2f37-3115-9c67-115435d102b8 imgt:mAb_809|imgt:inn_name|cetrelimab imgt:Clone_783|rdf:type|obo:NCIT_C37925 imgt:Product_823dd5e7-e3e3-3909-90c0-6b381ca01691|imgt:isProducedBy|imgt:Sichuan_Clover_Biopharmaceuticals_Inc imgt:Product_6bc1d7d7-3572-3445-908f-a32d9aa7218d|rdf:type|obo:NCIT_C51980 imgt:Product_2dc565df-2fcf-3fe3-9975-3a850426b48a|imgt:commun_name|AMG 110 imgt:Product_9de76b2d-1b1c-3b8c-a3f8-9ae079c8a4b0|imgt:hasStudyProduct|imgt:StudyProduct_723687d1-7878-30f1-987e-b1bc5e2c19ec imgt:mAb_767|rdf:type|obo:NCIT_C170182 imgt:Construct_1023|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Construct_820|imgt:isConstructOf|imgt:CPCA_PROTEIN-FC_820 imgt:mAb_1037|imgt:inn_number|11236 imgt:Construct_13|imgt:isConstructOf|imgt:IgG1-nd_13 imgt:Segment_115_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Construct_465|rdf:type|imgt:Construct imgt:Segment_1233_1|obo:BFO_0000050|imgt:Construct_1233 imgt:Solid_tumors|imgt:isClinicalIndicationOf|imgt:StudyProduct_415b73aa-f37b-38eb-a7bf-4854835b0a6e imgt:contact_analysis|rdfs:label|contact_analysis imgt:StudyProduct_58071149-f02d-3be0-9617-339e652fbe0f|imgt:hasClinicalIndication|imgt:Acute_lymphocytic_leukemia_(ALL) imgt:Cancers_pancreatic|imgt:isClinicalIndicationOf|imgt:StudyProduct_df2b1eee-0658-3294-a5a9-6de278413282 imgt:11330|imgt:isImgtStructureEntryOf|imgt:mAb_1031 imgt:Product_9626ca17-3e54-3f1b-821a-f29de93babf6|imgt:isProducedBy|imgt:AbbVie_Inc imgt:mAb_917|imgt:inn_recommended_list|82 (2019) _:Bf2d472bcff88b4db21dadec08d516dac|imgt:isDecidedBy|imgt:FDA imgt:Product_bf01e52c-681c-3e27-a65a-7e56b7753697|imgt:hasStudyProduct|imgt:StudyProduct_0b83fc85-7c3f-32c6-bcac-bd3fabb42c9a imgt:Construct_1278|rdfs:label|Construct_1278 _:B76deaa84a86ba9a1fa74fcd78849e1aa|rdf:type|obo:NCIT_C53285 imgt:Product_0d11bcb8-8209-384d-bad3-07da9a1ee33c|rdf:type|obo:NCIT_C51980 _:Bf4538d00538d181211a1e6f9d86fb8c6|imgt:hasDesignation|imgt:Orphan_drug imgt:StudyProduct_9cd41eec-27b9-3ac7-969a-fe29e7e4d50a|rdf:type|obo:NCIT_C174271 imgt:Construct_474|rdfs:label|Construct_474 imgt:Product_442a60e9-44f1-3d58-be60-70178de04384|rdf:type|obo:NCIT_C51980 imgt:Merck_KgaA|imgt:produces|imgt:Product_f585c3aa-a22a-3afb-9114-31450ab8bf8e imgt:StudyProduct_87c3cbea-c445-3acc-a03a-a2beadcb04ee|imgt:hasClinicalPhase|imgt:Phase_M _:Ba27471d790d19f3818bcac34611989a5|imgt:hasStatut|imgt:application_withdrawal imgt:mAb_271|imgt:inn_name|talizumab imgt:Construct_971|imgt:hasImgtLabel|imgt:VH-VH%27-VH_trivalent imgt:StudyProduct_3ade6364-93b7-321a-9b05-11dd7e21958f|imgt:application_type|Therapeutic imgt:CD47|imgt:isTargetOf|imgt:FPIA_%5BPROTEIN%5D2-FC_1293 imgt:StudyProduct_07369c12-48cc-3b33-a54b-e9d233a35bec|imgt:application_type|Therapeutic imgt:Mus_musculus|dc:identifier|imgt_000330 pubmed:16139892|dc:contributor|Schlereth B imgt:F(ab%27)2-G1-nd_123|imgt:isMabReceptorOf|imgt:mAb_123 imgt:StudyProduct_57a8b408-a3da-3c62-a3f2-c90f8f441843|imgt:application_type|Therapeutic imgt:_CHO-K1|imgt:isExpressionSystemOf|imgt:StudyProduct_d2e57127-b131-3441-881d-1f8e65a7880d imgt:FGF23|skos:definition|FGF23 (fibroblast growth factor 23) imgt:StudyProduct_9e386d2b-e022-3e11-ba72-92e90c36e5f8|imgt:hasClinicalPhase|imgt:Phase_I imgt:Product_0e424174-ac1f-3f3b-842b-0ddcc9a70b4d|rdf:type|obo:NCIT_C51980 imgt:mAb_1021|rdfs:label|mAb_1021 imgt:StudyProduct_343f8f46-06fe-3db0-ad78-66ae433e2087|imgt:hasClinicalPhase|imgt:Discontinued imgt:mAb_1005|imgt:clinical_trials|3 studies found, 2 recruiting imgt:StudyProduct_b5c5b27d-801b-3e42-809a-973b01a08121|rdfs:label|StudyProduct_b5c5b27d-801b-3e42-809a-973b01a08121 imgt:StudyProduct_b4aa5e3e-23d4-3796-a5fc-b1fad12a424f|imgt:hasClinicalPhase|imgt:Phase_I imgt:StudyProduct_b98a8e2b-2a19-32a0-bf8b-098767b79194|imgt:isStudyProductOf|imgt:Product_e75484d6-63ef-3d47-8150-d13346757f21 imgt:Carcinoma_cutaneous_squamous_cell|imgt:clinical_domain|Oncology imgt:IgG1-lambda_1199|http://semanticscience.org/resource/SIO_000291|imgt:RHD imgt:StudyProduct_e7ccbaca-89b8-33e8-962f-c19741fda74e|imgt:hasClinicalPhase|imgt:Phase_III imgt:mAb_567|imgt:inn_name|risankizumab imgt:mAb_317|rdfs:label|mAb_317 imgt:hasImgtStructureEntry|rdf:type|owl:ObjectProperty imgt:Construct_825|obo:BFO_0000051|imgt:Segment_825_2 imgt:StudyProduct_87e2c5f1-33e0-38ab-a626-e465e699fb62|rdf:type|obo:NCIT_C174271 imgt:mAb_657|imgt:inn_name|utomilumab imgt:Segment_205_1|obo:BFO_0000050|imgt:Construct_205 imgt:Product_e9ad6c68-27ee-31c2-86ce-72d047684265|imgt:hasStudyProduct|imgt:StudyProduct_ab7d8ffc-9070-3c4e-afbf-5efec0fbe8cc imgt:TCR2_Therapeutics_Inc|rdf:type|obo:NCIT_C54131 imgt:12023|rdf:type|obo:NCIT_C25402 imgt:StudyProduct_52d64598-ed50-3201-a067-7767d7a82e62|imgt:isStudyProductOf|imgt:Product_52d64598-ed50-3201-a067-7767d7a82e62 imgt:ENZ_1DOMAIN_695|http://semanticscience.org/resource/SIO_000291|imgt:Factor_substitute imgt:StudyProduct_531ed619-12fb-3aa0-b519-7fdb71523fd0|imgt:hasClinicalIndication|imgt:Allergic_asthma imgt:IgG1-nd_56|imgt:hasMolecularComponent|imgt:IG imgt:Construct_577|rdfs:label|Construct_577 imgt:Construct_935|imgt:hasImgtLabel|imgt:%5BTNFSF18_(TNF_superfamily_member_18_AITRL_TL6_GITRL)%5D2-IGHG1_Fc_(Fragment_constant) imgt:Clone_60|obo:RO_0002162|imgt:Musmus imgt:mAb_566|imgt:hasOriginClone|imgt:Clone_566 imgt:StudyProduct_c79acac8-704a-38ac-87bf-2ccb50abfbc7|rdfs:label|StudyProduct_c79acac8-704a-38ac-87bf-2ccb50abfbc7 imgt:Bio_Products_Laboratory|rdf:type|obo:NCIT_C54131 imgt:IgG1-kappa_1125|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:POLYA_SITE|rdfs:label|POLYA_SITE imgt:mAb_1204|imgt:hasProduct|imgt:Product_c43354f7-d1ee-3952-bf61-d7f3d2f18d35 imgt:IgG2-kappa_723|http://semanticscience.org/resource/SIO_000291|imgt:CD40 imgt:StudyProduct_be6e6aeb-e25a-3b7b-8bba-6d8eb655e6d9|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_da35b2ab-85c1-3f27-83f8-e101e879cce1|imgt:application_type|Therapeutic imgt:Product_8ab7fc81-b8d6-308e-9064-5a153be43d1b|imgt:commun_name|AVB-S6-500 imgt:F(AB%27)2-ALPHA-1_KAPPA|skos:definition|F(ab')2 comprising the VH-CH1 domains from two H-ALPHA-1 chains and two L-KAPPA chains imgt:mAb_457|imgt:inn_proposed_list|108 (2012) obo:SO_0000528|rdf:type|owl:Class _:B2a797f528e6c5c0d8015e6d2f38e48cf|imgt:hasStatut|imgt:approval imgt:mAb_487|imgt:hasMabReceptor|imgt:FPIA_%5BPROTEIN%5D2-FC_487 imgt:StudyProduct_bb3f95c6-4b3d-35c9-ba6e-13fe3700b5fa|imgt:hasClinicalIndication|imgt:Solid_tumors imgt:aldifitox:diphteriatoxin_(AB_toxin)_1-387-IL2_(interleukin_2_IL-2)_1-133|rdfs:label|aldifitox : diphteriatoxin (AB toxin) 1-387 - IL2 (interleukin 2, IL-2) 1-133 imgt:StudyProduct_7640506d-2ee9-31ad-b125-b376dafa5452|imgt:hasClinicalPhase|imgt:Phase_I imgt:StudyProduct_a4e4cb9c-3386-3914-b91c-5b6b4e2f790e|imgt:hasClinicalIndication|imgt:Steroid-refractory_acute_GvHD_(SR-GvHD) imgt:IgG1-kappa_504|rdfs:comment|IgG1 - kappa imgt:Construct_29|rdfs:label|Construct_29 imgt:Product_8aa4e449-9a5b-35c3-808a-3f569719efe1|imgt:hasStudyProduct|imgt:StudyProduct_6418f006-4cac-3121-b996-6d1a74606cd0 imgt:StudyProduct_34263c1d-fc01-3448-bb8c-028a50fab1de|rdf:type|obo:NCIT_C174271 imgt:Product_9515173d-a62b-3801-8bd7-de87e171e906|rdfs:label|Product_9515173d-a62b-3801-8bd7-de87e171e906 imgt:mAb_426|imgt:inn_number|9635 imgt:StudyProduct_a7e6a2e7-3932-3a92-9a59-238a750139d0|imgt:hasClinicalPhase|imgt:Phase_II imgt:mAb_536|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=536 imgt:Acute_coronary_syndrome_(ACS)|imgt:isClinicalIndicationOf|imgt:StudyProduct_69aef7a2-4f28-35e9-a5bd-e7d5df4e120e imgt:mAb_412|rdf:type|imgt:INN imgt:Construct_681|imgt:isConstructOf|imgt:PROTEIN_1DOMAIN-PEG_681 _:Bc841c9dc3512dcbf048cfea2a6931b36|imgt:isDecisionOf|imgt:StudyProduct_344e061b-7133-38c4-8a1f-ec5e4af282a2 imgt:StudyProduct_c604db8e-c214-3403-8739-e794fbdea73b|imgt:isStudyProductOf|imgt:Product_45764f66-c3ab-3d8a-83e6-4c68ea46c921 imgt:Product_6de5e4cc-b4a5-392b-a018-f88bb89a8395|imgt:isProductOf|imgt:mAb_811 imgt:CD5|imgt:isTargetOf|imgt:IgG1-nd_MM_314 imgt:%5BV-kappa’-VH-h-CH2-CH3_V-kappa-VH’%5D2|rdf:type|imgt:SegmentLabels _:B72c9affccd5d6107a87ce96c04826a8f|imgt:hasStatut|imgt:withdrawal imgt:TNFRSF17|imgt:isTargetOf|imgt:IgG1-kappa-4cys-drug_784 https://doi.org/10.1371/journal.pmed.0030237|dc:contributor|ter Meulen J. imgt:mAb_673|imgt:inn_recommended_list|73 (2015) imgt:IgG4-kappa_1112|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG4-kappa.png _:B61299c4b05388f506f4863e60bdc19a3|owl:members|_:B5e86292dX2D92ebX2D4958X2D9867X2Decdf00aebd9e imgt:mAb_923|imgt:inn_recommended_list|82 (2019) imgt:StudyProduct_e18346b4-c502-3a24-9514-3f9ecb2d5d74|imgt:hasClinicalPhase|imgt:Phase_M imgt:Segment_1269_1|rdfs:label|Segment_1269_1 imgt:mAb_629|imgt:imgt_note| The proline linker facilitates the synthesis of a predominant (90%) positional isomer which allows for further increases in stability and a longer half-life than previous PEG conjugates imgt:Product_25623bb4-dbeb-3eb1-8289-b2926b511903|imgt:hasStudyProduct|imgt:StudyProduct_f9931cb1-61ae-324e-a2be-bf35bad4a04b imgt:StudyProduct_999c3e3c-f67a-3f68-8491-44ef9f001b19|imgt:application_type|Therapeutic imgt:IgG1-nd_42|imgt:hasConstruct|imgt:Construct_42 imgt:mAb_576|imgt:inn_name|afasevikumab imgt:StudyProduct_b1f755db-a205-37b9-a833-082549620702|rdfs:label|StudyProduct_b1f755db-a205-37b9-a833-082549620702 imgt:monovalent|skos:definition|monovalent imgt:mAb_1049|imgt:hasMabReceptor|imgt:scFv-Lambda-heavy_1049 imgt:mAb_679|imgt:inn_proposed_list|118 (2017) imgt:Segment_949_1|rdfs:label|Segment_949_1 imgt:StudyProduct_8ea9cb56-50d7-3016-a7f3-8606e22666dc|imgt:application_type|Therapeutic imgt:Gilead|imgt:produces|imgt:Product_20a3f071-ad32-3ce5-bf2d-1658fb45f799 imgt:TBP-1_(_tumor_necrosis_factor_(TNF)_binding_protein_variant_1)|imgt:construction_detail|TBP-1 ( tumor necrosis factor (TNF) binding protein variant 1) imgt:IgG1-kappa_801|http://semanticscience.org/resource/SIO_000291|imgt:ICOS imgt:mAb_796|imgt:clinical_trials|13 studies found, 4 recruiting imgt:mAb_644|imgt:hasOriginClone|imgt:Clone_644 imgt:StudyProduct_a338e658-345d-3777-af9b-578f4b8496d0|imgt:isStudyProductOf|imgt:Product_390fb47e-7119-3e38-9d5f-5f1c1b59df0d imgt:StudyProduct_b0bb0702-9e9a-3783-97b1-b32ed1cc0a37|imgt:hasClinicalIndication|imgt:Carcinoma_esophageal imgt:Product_22e71cb5-4fe7-3627-8a07-360ee7654a02|rdfs:label|Product_22e71cb5-4fe7-3627-8a07-360ee7654a02 imgt:INIT-CONS|skos:definition|consensus sequence upstream the INIT-CODON, in 5'UTR imgt:VH-VH%27_523|rdfs:comment|VH - VH' imgt:StudyProduct_5e71b1dd-9ab2-3249-a5d9-508cd9d5ced1|imgt:application_type|Therapeutic imgt:Segment_164_1|obo:BFO_0000050|imgt:Construct_164 obo:NCIT_C88315|rdf:type|owl:Class obo:NCIT_C179103|rdfs:subClassOf|obo:NCIT_C1909 imgt:Fab-G1-TOXIN_BIG-kappa_65|rdfs:comment|Fab-G1-TOXIN_BIG-kappa imgt:StudyProduct_15bfb8dd-543a-30d8-b252-cae3eafb8727|imgt:hasClinicalIndication|imgt:Peripheral_Arterial_Disease_(PAD) imgt:StudyProduct_da25047e-345c-3792-b89f-73042c019bf0|rdfs:label|StudyProduct_da25047e-345c-3792-b89f-73042c019bf0 imgt:StudyProduct_54430c50-7ea4-373d-be19-5cb1bfadd006|rdf:type|obo:NCIT_C174271 imgt:Product_c49fe1bd-70e4-3192-91d0-1125b060119b|imgt:isProducedBy|imgt:MedImmune imgt:Product_94a274de-ded8-3d8a-9d04-5df215c7d578|imgt:isProductOf|imgt:mAb_201 imgt:Construct_913|obo:BFO_0000051|imgt:Segment_913_1 imgt:Segment_612_1|rdf:type|imgt:Segment imgt:mAb_794|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=794 imgt:IG-Heavy-Delta-IGHD|rdfs:label|IG-Heavy-Delta-IGHD imgt:half-G1-kappa_scFv-HEAVY-LAMBDA-h-CH2-CH3_919|obo:RO_0002162|imgt:Chi imgt:mAb_612|rdfs:label|mAb_612 imgt:StudyProduct_86a7ff24-9b88-321d-bcaf-4ac808891ad6|rdf:type|obo:NCIT_C174271 imgt:11280|rdfs:label|11280 imgt:partially_spliced|rdf:type|imgt:Molecule_StructureType imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_08b9cb90-6d16-3be4-9762-c96c5f4f1501 imgt:Product_97984f90-666b-3255-b4ca-53dfa6fe9b05|imgt:commun_name|MBL-CDA1 imgt:MAbReceptor_313|rdf:type|imgt:MAbReceptor imgt:StudyProduct_c6006853-c81f-353b-b151-1d6f639683af|imgt:hasClinicalPhase|imgt:Phase_III imgt:mAb_435|imgt:hasMabReceptor|imgt:IgG1-nd_435 imgt:Product_042c8435-6492-3cdb-a685-d17d13c06937|imgt:commun_name|REGN10933 imgt:StudyProduct_24a1be0f-c642-3557-abfb-e119d3847c1f|imgt:isStudyProductOf|imgt:Product_3c59ddc7-2c9e-3f59-aa28-0ec6b12703f4 imgt:Clone_91|rdfs:label|Clone_91 imgt:Shanghai_Junshi_Biosciences_Co_Ltd|rdfs:comment|Shanghai , China imgt:mAb_656|imgt:inn_number|10383 imgt:Product_be8c10fb-b03e-3972-b6fa-603cee6cfaf1|imgt:commun_name|GS-5423 imgt:mAb_500|imgt:inn_recommended_list|73 (2015) _:B9f4dac0d8a020a96fca7f19fa3159c66|imgt:isDecisionOf|imgt:StudyProduct_d27f3450-4dac-3002-9b81-f849b03174fa imgt:mAb_122|imgt:hasProduct|imgt:Product_5e6fb815-05e1-389d-909a-e10ff1c0fa2c imgt:Fc-Epsilon|imgt:isDescribedBy|imgt:FC-EPSILON imgt:mAb_991|imgt:hasMabReceptor|imgt:IgG2b-kappa_991 imgt:_CHOK1SV_(expresses_glutamine_synthetase_(GS)_endogenously)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_bbd57bc5-9f9c-39a5-8a24-1a13ad4e4c85 imgt:StudyProduct_14f772b0-9f8c-32bb-9418-26d0843c3f20|imgt:hasClinicalPhase|imgt:Phase_I/II http://semanticscience.org/resource/SIO_000291|rdfs:label|hasTarget imgt:Product_ef533a31-26d4-3550-b796-9797afee966f|imgt:isProductOf|imgt:mAb_79 obo:NCIT_C166960|rdf:type|owl:Class imgt:StudyProduct_93d17e42-ebe3-34a2-a91a-e06d34681968|imgt:isStudyProductOf|imgt:Product_30252648-22d2-3bbf-924d-91ade8b9ddd3 imgt:Zoetis|imgt:produces|imgt:Product_3adee3e6-6ae0-336d-9a0a-2290f3ed968a imgt:IgG1-lambda_643|imgt:isMabReceptorOf|imgt:mAb_643 imgt:StudyProduct_0e01938f-c48a-3cfb-9f22-17fbfb00722d|rdf:type|obo:NCIT_C174271 _:Bce35687bdf7989fcde7086659b1f891c|rdf:type|obo:NCIT_C53285 imgt:Segment_494_1|obo:BFO_0000050|imgt:Construct_494 imgt:IL2_(Pr21-153)|rdf:type|imgt:DomainLabel imgt:ICOS|skos:definition|ICOS (inducible T-cell costimulator, activation-inducible lymphocyte immunomediatory molecule, AILIM, CD278) imgt:StudyProduct_c69aaa98-95ca-3d2b-88c1-fa0e760053df|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_5a5c7b16-1104-3817-8817-64e9caa4b33b|imgt:application_type|Therapeutic imgt:Product_946b8f52-507d-3bbc-a1e3-51d4ec44415b|rdf:type|obo:NCIT_C51980 imgt:Construct_1242|rdf:type|imgt:Construct imgt:Construct_403|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Segment_954_1|imgt:has_rank|1 imgt:Product_9b5614c6-8750-39f5-8dfe-86ffd967ed48|rdfs:label|Product_9b5614c6-8750-39f5-8dfe-86ffd967ed48 imgt:Clone_1089|imgt:clone_name|193.49-20 imgt:StudyProduct_1aea0703-4fa8-3be8-823e-3a0b4259c959|imgt:application_type|Therapeutic imgt:Segment_92_1|imgt:has_rank|1 imgt:IgG1-kappa-3cys-drug_712|rdfs:comment|IgG1-kappa-3cys-drug imgt:StudyProduct_3fe8e925-30b8-30ce-8efb-22088860ac21|imgt:isStudyProductOf|imgt:Product_827a202e-1f6c-316d-b5b0-b1ebd391a8c6 imgt:Segment_526_1|rdfs:label|Segment_526_1 imgt:IgG1-kappa_474|rdfs:comment|IgG1 - kappa imgt:IgG1-kappa_168|obo:RO_0002162|imgt:Homsap imgt:IgG4-kappa_564|imgt:hasMolecularComponent|imgt:IG imgt:IgG4-lambda_1063|rdf:type|imgt:MAbReceptor imgt:5BVJ|rdf:type|obo:NCIT_C25402 imgt:9306|rdf:type|obo:NCIT_C25402 _:B82f7aea8366d680a656dc2abbce52922|imgt:isDecidedBy|imgt:EMA imgt:StudyProduct_33e211b6-ebe4-3a0c-b988-d774ed17c900|imgt:development_technology| Human antibody phage display library imgt:mAb_1133|imgt:imgt_note| WHO Drug Information, Vol. 34, No. 3, 2020. Proposed INN List 124 – COVID-19 (special edition) (9 October 2020) pages 642-669. Proposed INN List 124 (19 December 2020, published on 22 January 2021) pages 929-1102. imgt:IgG1-nd_2|imgt:hasMolecularComponent|imgt:IG imgt:IG-Heavy|imgt:hasChainTypeLevel|imgt:IG-Chain imgt:Construct_366|imgt:isConstructOf|imgt:IgG1-kappa_366 imgt:IgG1-kappa_326|rdf:type|imgt:MAbReceptor imgt:Product_3002b6bc-d17a-3738-b656-5b25d617ba95|imgt:isProductOf|imgt:mAb_217 imgt:StudyProduct_8fa31b06-d692-3a3e-8f4b-bb37c825e8ef|imgt:hasClinicalPhase|imgt:Phase_I imgt:Segment_735_1|obo:BFO_0000050|imgt:Construct_735 imgt:StudyProduct_f39528a1-ec68-39ee-a847-69451657ce25|imgt:isStudyProductOf|imgt:Product_94ff4548-cf82-3333-b651-af7954d824c6 imgt:Construct_1098|rdf:type|imgt:Construct imgt:Clone_148|imgt:isOriginCloneOf|imgt:mAb_148 imgt:Inflammatory_diseases|imgt:isClinicalIndicationOf|imgt:StudyProduct_551ac7e6-d7c1-3505-a362-a731b13d1d19 imgt:scFv-scFv-scFc_kappa-lambda_1055|obo:RO_0002162|imgt:Hum imgt:StudyProduct_a653ecce-5953-3e12-95f3-70101cdfde28|imgt:hasClinicalPhase|imgt:Phase_I imgt:mAb_292|imgt:inn_proposed_list|100 (2008) imgt:Product_1c81621a-ff42-3937-8f41-30279f630940|imgt:hasStudyProduct|imgt:StudyProduct_610139e9-1ad4-34aa-99d3-50d54729d262 imgt:Product_d1cda899-6b1f-3fc5-9c4c-cb14c62b0c13|rdf:type|obo:NCIT_C51980 imgt:StudyProduct_64f2be13-231c-3c8c-858b-8442a46a18d2|imgt:hasDecision|_:Bc6d33d3255c332dd6ecc193d5c85034b imgt:IgG1-kappa_17|imgt:isMabReceptorOf|imgt:mAb_17 imgt:10545|imgt:isImgtStructureEntryOf|imgt:mAb_729 imgt:StudyProduct_d141e5ff-8372-358a-8d88-fcc86d2244e0|imgt:hasClinicalIndication|imgt:Colitis_ulcerative_(UC) imgt:StudyProduct_00ad372a-0d4f-39a5-900f-438420dc71ea|imgt:hasClinicalPhase|imgt:Phase_II imgt:Aptevo_Therapeutics|rdfs:label|Aptevo Therapeutics imgt:TNFSF10-COL1A1|rdfs:label|TNFSF10-COL1A1 imgt:11461|rdfs:label|11461 imgt:_CHOK1SV_(lacking_the_glutamine_synthetase_(GS)_gene)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_e431bdd5-d4bb-3422-a165-dec80514e81c imgt:Fc_receptor|rdfs:subClassOf|imgt:related_protein_of_immune_system imgt:Construct_236|obo:BFO_0000051|imgt:Segment_236_1 imgt:IL2RA|imgt:isTargetOf|imgt:IgG1-kappa_36 imgt:5'J-REGION|rdfs:label|5'J-REGION imgt:Construct_529|imgt:isConstructOf|imgt:IgG4-kappa_529 imgt:Clone_1290|imgt:isOriginCloneOf|imgt:mAb_1290 imgt:mAb_257|imgt:hasMabReceptor|imgt:MAbReceptor_257 imgt:StudyProduct_34a5fae0-1542-3908-9606-16dd2eb055ac|imgt:hasClinicalIndication|imgt:Rabies_post-exposure imgt:StudyProduct_8fafb39d-a882-31f1-80c7-29f8cbf3627b|rdfs:label|StudyProduct_8fafb39d-a882-31f1-80c7-29f8cbf3627b imgt:FPIA_%5BPROT-PROT%5D2-FC_615|rdf:type|imgt:MAbReceptor imgt:StudyProduct_06e79333-0df6-3903-975e-83ef7a568ef7|rdfs:label|StudyProduct_06e79333-0df6-3903-975e-83ef7a568ef7 imgt:Clone_1183|imgt:isOriginCloneOf|imgt:mAb_1183 imgt:Product_a3222722-cf6b-3189-8b44-5c791cff2a5e|rdf:type|obo:NCIT_C51980 imgt:Construct_1024|rdf:type|imgt:Construct imgt:Segment_1231_1|rdfs:label|Segment_1231_1 imgt:IGF1|rdfs:label|IGF1 imgt:StudyProduct_1e3d13d6-30e9-30d3-90c2-86212912f6e9|imgt:application_type|Therapeutic imgt:StudyProduct_c4f53f99-c901-3b46-bc43-36742bc83cd0|imgt:hasClinicalPhase|imgt:Phase_I imgt:H5|skos:definition|hinge exon 5 of IG heavy C-GENE-UNIT _:B313a4f1c990a0cae778ff0f97a0cf2fa|imgt:isDecidedBy|imgt:FDA imgt:9369|rdfs:label|9369 imgt:mAb_305|imgt:inn_name|faralimomab imgt:StudyProduct_3fd941bf-0663-37c6-81e0-47e586d03fba|rdf:type|obo:NCIT_C174271 imgt:mAb_172|rdfs:label|mAb_172 imgt:Construct_1158|obo:BFO_0000051|imgt:Segment_1158_4 imgt:Segment_473_1|imgt:has_rank|1 imgt:mAb_65|imgt:hasImgtStructureEntry|imgt:8598 imgt:IgG1-lambda_323|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-lambda.png _:B3d29f285a37bc962fa40f92edeefc10d|dc:date|2016-05-18 imgt:Product_1e6dcbf5-881e-3dae-a9c2-c7d5ca5aaceb|rdfs:label|Product_1e6dcbf5-881e-3dae-a9c2-c7d5ca5aaceb imgt:IgG1-kappa_506|rdf:type|imgt:MAbReceptor imgt:IgG4-lambda_1031|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG4-lambda.png imgt:IL2RA|imgt:isTargetOf|imgt:IgG1-kappa_228 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3393390|dc:contributor|Richie D.L. imgt:StudyProduct_340cb88e-bb79-3b53-9e2a-cbd43b517c55|imgt:hasDecision|_:B4f59a5c8713a63eeb2695675c4dfd339 imgt:Lymphoma_enteropathy-associated_T_cell_(EATL)|imgt:isClinicalIndicationOf|imgt:StudyProduct_d2c92349-c4d2-30cc-bee6-3394752f0c74 imgt:Construct_469|imgt:isConstructOf|imgt:IgG2-kappa_469 imgt:StudyProduct_b35e865b-2d30-3d21-8b19-f6b43d138be5|imgt:hasClinicalIndication|imgt:Asthma imgt:isLitSequenceOf|rdfs:subPropertyOf|obo:GENO_0000251 imgt:Segment_1258_1|imgt:hasImgtLabel|imgt:IgG1-lambda2 imgt:IgG4-kappa_807|imgt:isMabReceptorOf|imgt:mAb_807 imgt:Clone_493|rdf:type|obo:NCIT_C37925 imgt:StudyProduct_062c20ec-d304-30b1-9eec-ad060650ce0b|imgt:hasClinicalPhase|imgt:Phase_M imgt:IgG1-kappa_765|imgt:hasMolecularComponent|imgt:IG imgt:Product_e6d34b40-0690-30b5-ae44-fb644ef0dfed|rdf:type|obo:NCIT_C51980 imgt:StudyProduct_73efe3b5-92db-30db-bd60-e6ce0edfe013|imgt:hasClinicalIndication|imgt:Solid_tumors imgt:Construct_571|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Product_aac2ba8b-69b0-31aa-b7c9-b2dc4b8f4de6|rdfs:label|Product_aac2ba8b-69b0-31aa-b7c9-b2dc4b8f4de6 imgt:StudyProduct_493e2fe7-7cc7-3bf7-8f5d-f255a8d4b409|imgt:hasExpressionSystem|imgt:_CHO-S_(Chinese_Hamster_Ovary)_cells_suspension_culture imgt:DuPont_Merck_Pharmaceutical|rdf:type|obo:NCIT_C54131 imgt:Segment_987_1|imgt:has_rank|1 imgt:StudyProduct_44f02f71-fa31-3d0d-b5d3-9435a6d250ed|imgt:development_technology| Medarex’s UltiMAb® imgt:StudyProduct_d609ac9e-2d3a-3f30-8145-cc39945744f4|rdfs:label|StudyProduct_d609ac9e-2d3a-3f30-8145-cc39945744f4 imgt:mAb_1193|imgt:hasProduct|imgt:Product_7cd4b25d-63bc-3c61-abff-155a50cfecb1 imgt:mAb_986|rdfs:label|mAb_986 imgt:mAb_630|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=630 pubmed:25788700|dc:contributor|Keyes F imgt:mAb_312|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=312 imgt:Segment_832_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:IgG1-kappa-%5BscFv%5D2-lambda_545|http://semanticscience.org/resource/SIO_000291|imgt:IGF1R _:Bb11a96f97be850bb0989323d9e835fe0|imgt:isDecidedBy|imgt:EMA imgt:StudyProduct_a6860c46-8ca9-3f3b-92a0-6aee7665ba18|imgt:hasClinicalPhase|imgt:Phase_I/II imgt:CD22|imgt:isTargetOf|imgt:IgG1-nd_40 imgt:StudyProduct_8de49a78-c152-3081-a848-991cbf0a7e39|imgt:application_type|Therapeutic imgt:mAb_578|imgt:inn_recommended_list|75 (2016) imgt:mAb_757|rdfs:label|mAb_757 imgt:StudyProduct_aed540b8-ec0e-3f5d-9751-74a55f126241|rdfs:label|StudyProduct_aed540b8-ec0e-3f5d-9751-74a55f126241 imgt:riabni™|rdfs:label|RIABNI™ imgt:Construct_75|rdfs:label|Construct_75 imgt:F10|skos:definition|F10 (coagulation factor 10, coagulation factor X) imgt:mAb_1193|imgt:inn_number|11800 pubmed:2480605|dc:contributor|Berger EA imgt:IgG1-kappa_96|imgt:isMabReceptorOf|imgt:mAb_96 imgt:INSR|imgt:isTargetOf|imgt:IgG1-kappa-ENZYME_791 imgt:Product_1ecfbd73-bd44-3962-8d08-3af82d492b28|imgt:hasStudyProduct|imgt:StudyProduct_1ac3ad92-0b63-3d1e-894d-38863d15c6a5 imgt:CPCA|rdf:type|imgt:composite_protein_for_clinical_applications imgt:Product_2dc565df-2fcf-3fe3-9975-3a850426b48a|imgt:commun_name|MT110 _:B8ddc97bc87100a40968d27bde3186c1f|imgt:isDecidedBy|imgt:FDA imgt:Product_987986ac-60bb-3e4d-ba3d-78aae99510bc|imgt:isProducedBy|imgt:Pfizer imgt:3PP3|rdf:type|obo:NCIT_C25402 imgt:Canlupfam_CD52|skos:definition|Canlupfam CD52 (CD52 molecule) imgt:mAb_540|imgt:inn_proposed_list|112 (2014) imgt:StudyProduct_b54609dc-bd12-356e-a5bf-77c43ed0825f|imgt:isStudyProductOf|imgt:Product_8b8b1181-7875-3ca3-aed3-32c1f2536311 imgt:Construct_302|rdf:type|imgt:Construct imgt:StudyProduct_139c25e2-58bd-3782-846d-1abdc865d72e|imgt:isStudyProductOf|imgt:Product_8892de96-5fe3-389f-a136-98d4bfc4724a imgt:mAb_701|imgt:hasProduct|imgt:Product_36dae934-299e-3c35-a473-cb615954069c imgt:Inflammatory_diseases|rdf:type|obo:NCIT_C185637 imgt:influenza_B_virus_hemagglutinin|obo:RO_0002162|imgt:InfBvir imgt:Product_557d6f3c-8aa3-35e6-bb7d-6df5196f42e8|rdf:type|obo:NCIT_C51980 imgt:IgG2b_Kappa|rdfs:label|IgG2b_Kappa _:Bde72025626b3729c3542aafedce82d63|rdf:type|obo:NCIT_C53285 imgt:StudyProduct_7ff14d1e-e1ee-32c2-a20f-569d99384d58|imgt:application_type|Therapeutic imgt:StudyProduct_a5fee61c-61c3-387f-b88a-915bf034be05|imgt:application_type|Therapeutic imgt:StudyProduct_5ff62102-e848-3f73-a032-36953e1cfc52|imgt:hasClinicalPhase|imgt:Phase_M obo:NCIT_C121949|rdf:type|owl:Class imgt:Product_a7783cec-9ac8-35f9-9629-3982e07c2ba0|imgt:isProductOf|imgt:mAb_334 imgt:mAb_1232|rdf:type|obo:NCIT_C1909 imgt:IG-GAMMA-1-%5BTGFBR2%5D2_KAPPA|rdfs:label|IG-GAMMA-1-[TGFBR2]2_KAPPA imgt:FC-GAMMA-1_731|http://semanticscience.org/resource/SIO_000291|imgt:FCGRT imgt:CLASSIFICATION|rdfs:label|CLASSIFICATION _:Bc658917cb2b13c0bf2036cecea05a62e|dc:date|2014-08-25 pubmed:2843774|rdfs:label|PMID_2843774 imgt:mAb_466|imgt:hasMabReceptor|imgt:IgG1-kappa_466 _:B6ececc0777daf44de38865b59a7ad5c3|imgt:isDecidedBy|imgt:FDA obo:NCIT_C179065|rdf:type|owl:Class imgt:Product_cd3c7721-1cc7-3d35-9b13-b8b3103fe71c|imgt:commun_name|CCR5-mAb imgt:StudyProduct_52aec5c4-8017-318a-be45-cf1c1533a0fa|imgt:hasClinicalIndication|imgt:Non-Hodgkin's_lymphoma_(NHL)_follicular_CD20_positive_relapsed_or_refractory_low_grade _:B8050f1c81bef2a2befb7e8bd6799d27f|imgt:isDecisionOf|imgt:StudyProduct_c4cda74f-687e-35cb-9659-ec7d4f939431 imgt:mAb_115|rdf:type|imgt:INN imgt:StudyProduct_f0c8977d-e83e-3a42-b1ae-a6e1a47ee5c2|rdfs:label|StudyProduct_f0c8977d-e83e-3a42-b1ae-a6e1a47ee5c2 _:B50701193709f0a41a9b97b84a5831b15|imgt:hasDesignation|imgt:Orphan_drug imgt:Product_6087ae75-1628-344c-adc7-9279223adb25|imgt:commun_name|F16 scFv anti-tenascin C fused to IL2 imgt:Sepsis_toxic_shock|imgt:isClinicalIndicationOf|imgt:StudyProduct_28be0a14-2fba-3773-b625-52940c25b0b8 imgt:Product_e5ce155e-e05d-3dfc-93a5-26bc31a1072c|imgt:hasStudyProduct|imgt:StudyProduct_ea340336-e89e-3870-8589-fbab497767b7 obo:NCIT_C166827|rdf:type|owl:Class imgt:mAb_565|imgt:hasProduct|imgt:Product_6fc221fc-63c6-300f-8844-5210f60014c6 imgt:Construct_905|rdf:type|imgt:Construct imgt:Roche_F_Hoffmann-La_Roche_Ltd|imgt:produces|imgt:Product_aaf2e2c9-1c88-3eed-ab99-9dbe7332094a imgt:mAb_15|imgt:clinical_trials|10 studies found, 5 recruiting pubmed:25788700|dc:contributor|Spooner J imgt:mAb_882|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=882 imgt:IgG4-nd_3|imgt:hasConstruct|imgt:Construct_3 imgt:IFNAR1|imgt:isTargetOf|imgt:PROTEIN_1DOMAIN_623 imgt:Fab-nd-nd_187|imgt:isMabReceptorOf|imgt:mAb_187 imgt:Product_6b5c5fd9-8960-35c5-8529-7c4bc6114ae0|imgt:isProducedBy|imgt:Gilead imgt:Duchenne_muscular_dystrophy_(DMD)|rdf:type|obo:NCIT_C185637 imgt:Alpine_Immune_Sciences|imgt:produces|imgt:Product_b654dbe7-d35e-34d8-8247-e93e431a41f8 imgt:11021|rdfs:label|11021 imgt:Fab-Gamma-2_Kappa|rdf:type|imgt:ReceptorType imgt:9572|imgt:isImgtStructureEntryOf|imgt:mAb_415 imgt:mAb_629|imgt:hasProduct|imgt:Product_3a36a6b1-3c91-39b2-87d7-55e41990ef73 imgt:Product_432aca3a-1e34-3e33-9f35-a30c8f65edce|rdf:type|obo:NCIT_C51980 _:B1aeed2cf74b423013532aa9da2ee14ab|imgt:hasDesignation|imgt:Orphan_drug imgt:PROTEIN_1DOMAIN-PEG_737|obo:RO_0002162|imgt:Homsap imgt:mAb_37|imgt:centerwatch_link|http://www.centerwatch.com/drug-information/fda-approvals/drug-details.aspx?DrugID=945 imgt:StudyProduct_ffac5a55-cde1-3888-87c9-8b7a7cbed014|imgt:hasClinicalPhase|imgt:Phase_II imgt:StudyProduct_e933a9ea-56e6-33dd-9527-e49e61f16c93|rdf:type|obo:NCIT_C174271 _:Ba286b924adcb6055d2b3860d6434ad7f|rdf:type|obo:NCIT_C53285 imgt:IgG4-nd_272|obo:RO_0002162|imgt:Hum imgt:StudyProduct_d55443f5-070b-3435-acf3-6cb85f4b98c3|rdf:type|obo:NCIT_C174271 _:Bc7691881e5071c0b35e150ea506b4bb7|imgt:isDecisionOf|imgt:StudyProduct_8bc896ef-ddc2-370c-bd39-256effff24e0 _:B1aad377ca9d4d7ab8241bb63179eb825|rdf:type|obo:NCIT_C53285 imgt:IgG1-kappa_1250|rdfs:label|IgG1-kappa_1250 imgt:mAb_898|rdf:type|obo:NCIT_C166423 imgt:mAb_19|imgt:hasProduct|imgt:Product_8aa4e449-9a5b-35c3-808a-3f569719efe1 imgt:Product_5c0aac93-e5ec-3675-b1ef-16f7fbe485d4|imgt:commun_name|HuMax-CD20® imgt:Product_37063952-98fd-3fe4-9109-09b267840368|imgt:isProducedBy|imgt:MacroGenics_Inc imgt:IgG2-kappa_102|rdfs:comment|IgG2 - kappa imgt:F(AB%27)2-GAMMA-3_LAMBDA|rdf:type|imgt:IGProteolyticFragmentLabel imgt:StudyProduct_a4727270-51a2-39ad-a4c3-e1c0fa7af61a|rdf:type|obo:NCIT_C174271 imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_4b9163ff-aee3-3824-823f-d7e8827fa346 imgt:MH2-peptide|imgt:isDefinedBy|imgt:MH2-Beta-peptide _:Bd5f676da51f0c5c1ddf41d4aa14899cd|imgt:isDecidedBy|imgt:FDA 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imgt:StudyProduct_9215dd29-19a5-360f-9f0c-c9c5d5534fe4|rdfs:label|StudyProduct_9215dd29-19a5-360f-9f0c-c9c5d5534fe4 _:B00b36862342c9f1a695f4d7bca92c6f4|dc:date|2017-05-08 imgt:mAb_40|imgt:hasMabReceptor|imgt:IgG1-nd_40 imgt:Segment_604_1|obo:BFO_0000050|imgt:Construct_604 imgt:IgG1-kappa_590|imgt:isMabReceptorOf|imgt:mAb_590 imgt:StudyProduct_b08c3015-33c4-345c-9a3b-608affccfe49|imgt:application_type|Therapeutic obo:NCIT_C121379|rdf:type|owl:Class imgt:mAb_1296|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=1296 imgt:Graft-versus-host_disease_(GvHD)|imgt:isClinicalIndicationOf|imgt:StudyProduct_3abdc460-ed74-31b3-b553-27cf2bfb2c0b imgt:StudyProduct_e4bb4882-62d1-3476-850c-33bd403b7ad3|imgt:isStudyProductOf|imgt:Product_55aa2dba-a058-31a7-91b8-376994712cb7 imgt:Construct_113|rdf:type|imgt:Construct imgt:mAb_1268|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=1268 imgt:Segment_1181_1|obo:BFO_0000050|imgt:Construct_1181 imgt:mAb_1105|imgt:hasImgtStructureEntry|imgt:11861 imgt:IgG1-kappa_960|http://semanticscience.org/resource/SIO_000291|imgt:CTLA4 imgt:Product_6a160c4a-db89-347f-a136-7e561bce3c0f|rdfs:label|Product_6a160c4a-db89-347f-a136-7e561bce3c0f _:B11fd41f41ead1532b4c3b5f39a7db635|imgt:isDecidedBy|imgt:EC imgt:Product_2de293bd-1023-3307-9fbd-5af2cf15c7e6|imgt:commun_name|SB408075 imgt:Product_21b92b88-2674-3575-8a48-80255e478298|imgt:hasStudyProduct|imgt:StudyProduct_ca2e917d-4310-3324-a891-cf35fce0d42a imgt:IgG1-kappa_534|rdfs:label|IgG1-kappa_534 imgt:INTEGRIN-BETA-3|rdf:type|imgt:ChainLabels imgt:StudyProduct_4495f259-8824-3877-b42f-dde6cabec1b7|imgt:isStudyProductOf|imgt:Product_93b7132b-5be4-3248-9d55-bb48290a5de1 imgt:StudyProduct_a720fa50-312f-3e4f-8874-d39007ec9f23|imgt:hasExpressionSystem|imgt:_CHOK1SV_(expresses_glutamine_synthetase_(GS)_endogenously)_cells imgt:L-AA-chain|imgt:hasMoleculeUnit|imgt:chain_unit imgt:StudyProduct_d8d8bce1-46d4-3206-938f-d51e1184816b|imgt:hasClinicalPhase|imgt:Phase_M imgt:IgG1-kappa_96|imgt:hasConstruct|imgt:Construct_96 imgt:mAb_219|imgt:inn_name|ertumaxomab imgt:StudyProduct_5a15c3f0-69e3-3331-89a1-48edf40520f1|imgt:application_type|Therapeutic imgt:Product_f36504b9-7a54-3056-b3e8-26781525dfe1|imgt:isProductOf|imgt:mAb_440 imgt:StudyProduct_50c57a82-84df-34c5-bed8-09d115373427|rdf:type|obo:NCIT_C174271 _:Bf4538d00538d181211a1e6f9d86fb8c6|imgt:isDecidedBy|imgt:FDA _:Bc7691881e5071c0b35e150ea506b4bb7|dc:date|2013-02-01 imgt:Product_f0221536-d202-3194-8a6c-80a5b460de1b|imgt:hasStudyProduct|imgt:StudyProduct_02e6ed45-1e3c-3d4d-bdc7-e3ccfeb40215 imgt:mAb_936|imgt:inn_recommended_list|83 (2020) imgt:Product_67eb0a60-1489-389a-8509-6fd884738332|imgt:hasStudyProduct|imgt:StudyProduct_e714e853-6ae5-3de4-ad2b-40fe5d7eca8e imgt:Segment_732_2|imgt:has_rank|2 imgt:Clone_227|rdfs:label|Clone_227 imgt:StudyProduct_a779018f-4c09-321d-a9a5-bcd91e3cf91f|rdfs:label|StudyProduct_a779018f-4c09-321d-a9a5-bcd91e3cf91f imgt:Segment_298_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:mAb_1123|rdf:type|obo:NCIT_C158557 imgt:10557|imgt:isImgtStructureEntryOf|imgt:mAb_828 imgt:mAb_576|rdf:type|imgt:INN imgt:IL22_(interleukin_22_IL-22_ILTIF_IL-TIF)-IGHG2_Fc_(Fragment_constant)|imgt:construction_detail|Fusion - IL22 (interleukin 22, IL-22, ILTIF, IL-TIF) - IGHG2 Fc (Fragment constant) imgt:mAb_969|imgt:inn_proposed_list|121 (2019) imgt:StudyProduct_5f7d1571-b754-3f66-8ac2-d72782f2337c|imgt:application_type|Therapeutic imgt:mAb_37|imgt:hasImgtStructureEntry|imgt:8231 imgt:mAb_958|rdfs:label|mAb_958 imgt:IgM-kappa_193|http://semanticscience.org/resource/SIO_000291|imgt:endotoxin imgt:IgG4-kappa_155|imgt:isMabReceptorOf|imgt:mAb_155 imgt:MAbReceptor_1165|rdf:type|imgt:MAbReceptor _:B82d3eb42cf786219cf31f7520182677e|imgt:isDecidedBy|imgt:FDA imgt:StudyProduct_31b0c07e-c02c-334d-9608-003386de4210|imgt:hasClinicalIndication|imgt:Crohn's_disease_(CD) imgt:mAb_166|rdfs:label|mAb_166 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imgt:Product_4d3d1c57-c33d-3fb9-a04f-cdb7a0a344c2|imgt:isProductOf|imgt:mAb_76 _:Bfb6b5f5f1e7561d7255233388ba98f3b|imgt:isDecidedBy|imgt:FDA _:B27eda8e658e8e406fa2c3fc52ff8f967|rdf:type|obo:NCIT_C53285 imgt:StudyProduct_8909d1e6-7acf-301c-83f0-55ae992caf23|imgt:isStudyProductOf|imgt:Product_b5e598b6-8945-316b-8c71-ee8e8326048b imgt:mAb_892|imgt:inn_recommended_list|82 (2019) imgt:StudyProduct_a7f48d10-4d15-37ee-a32b-00a715ddd0d7|imgt:isStudyProductOf|imgt:Product_f56c8ab5-59fc-3984-8fc3-5948b6994588 imgt:StudyProduct_7c608379-7a72-3348-bbf8-0b597847afa4|rdf:type|obo:NCIT_C174271 imgt:mAb_236|imgt:imgt_note| Immunotoxin: An immunotoxin is an antibody linked (fused or conjugated) to a toxin. imgt:Product_b040dae5-3608-32e1-b3f2-9802ffb17c21|imgt:commun_name|CSL324 imgt:FGFR4|obo:RO_0002162|imgt:Homsap imgt:mAb_938|rdf:type|imgt:INN imgt:Construct_129|rdf:type|imgt:Construct imgt:Product_745490e4-4044-3296-9c53-5840facf85d0|rdf:type|obo:NCIT_C51980 imgt:XTL_Biopharmaceuticals|imgt:produces|imgt:Product_3e72db9b-e1f8-3042-b36a-b6d976d78dba obo:NCIT_C81166|rdfs:subClassOf|obo:NCIT_C1909 imgt:StudyProduct_7a8a4321-2c20-3c9b-b98e-ac1a3008529e|rdf:type|obo:NCIT_C174271 imgt:mAb_930|imgt:inn_name|cinpanemab imgt:VLRC|rdf:type|imgt:RPILabel imgt:mAb_332|rdfs:label|mAb_332 imgt:mAb_1116|imgt:hasMabReceptor|imgt:ALB-Tn3(2)_1116 imgt:Construct_777|obo:BFO_0000051|imgt:Segment_777_1 imgt:IgG1-kappa_403|http://semanticscience.org/resource/SIO_000291|imgt:TYRP1 imgt:StudyProduct_96f46e52-e9a8-3eeb-8b87-64e1abc367fe|imgt:hasExpressionSystem|imgt:_CHOK1SV_(expresses_glutamine_synthetase_(GS)_endogenously)_cells imgt:mAb_414|imgt:hasImgtStructureEntry|imgt:9599 imgt:Solid_tumors|imgt:isClinicalIndicationOf|imgt:StudyProduct_85b6b72e-1238-3b69-a3e0-ce8bd39a5396 imgt:mAb_1101|imgt:hasProduct|imgt:Product_25709140-bbc7-373c-9a44-2be9be3d8e9d imgt:BETA-ALPHA1_987|imgt:hasConstruct|imgt:Construct_987 imgt:Kyowa_Hakko_Kirin|rdfs:label|Kyowa Hakko Kirin imgt:IgG1-kappa_544|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png _:Bb361c75360909c8d70e95248a223b73e|dc:date|2011-03-25 imgt:StudyProduct_aac27e2f-8d9c-3b3b-92ec-b3a6372b757f|imgt:hasClinicalIndication|imgt:Cancers_gastric imgt:F7_(coagulation_factor_VII_coagulation_serum_prothrombin_conversion_accelerator)-XTEN|rdfs:label|F7 (coagulation factor VII, coagulation serum prothrombin conversion accelerator) - XTEN imgt:SELP|obo:RO_0002162|imgt:Homsap imgt:IgG1-kappa_810|rdfs:comment|IgG1 - kappa imgt:IgG4-kappa_970|imgt:isMabReceptorOf|imgt:mAb_970 imgt:IgG1-kappa_80|rdf:type|imgt:MAbReceptor imgt:Product_8e058ff0-4725-306f-82b2-de22387d53af|rdfs:label|Product_8e058ff0-4725-306f-82b2-de22387d53af imgt:IG-Heavy-Gamma-1-IGHG1|imgt:defines|imgt:IgG1_Kappa imgt:REMD_Biotherapeutics_Inc|imgt:produces|imgt:Product_1a4c8787-fe9d-3f7d-9de8-b2438df5d9b9 obo:NCIT_C38714|rdf:type|owl:Class imgt:Segment_516_1|imgt:has_rank|1 imgt:Product_2baba1ed-1fb0-315f-a829-937a1ea0335b|imgt:isProductOf|imgt:mAb_1219 imgt:9340|rdf:type|obo:NCIT_C25402 imgt:Product_31d88f86-f890-3c06-9160-b268bfdcdad5|rdf:type|obo:NCIT_C51980 imgt:Segment_551_1|rdf:type|imgt:Segment imgt:Segment_801_1|obo:BFO_0000050|imgt:Construct_801 imgt:Segment_75_1|imgt:has_rank|1 imgt:(N-D)-REGION|rdf:type|imgt:ComposedRegionLabel imgt:mAb_439|imgt:hasBibliographicReference|https://doi.org/10.1371/journal.pmed.0030237 imgt:Product_1ee293d6-44ea-3bcb-84c3-b34b51c264d4|imgt:hasStudyProduct|imgt:StudyProduct_c2402af5-16f0-3a7b-872f-e9498ca2173c imgt:StudyProduct_9ede639e-ad34-360b-bf1d-9638c08bbecc|rdf:type|obo:NCIT_C174271 imgt:IL3_(Pr20-152)|rdf:type|imgt:DomainLabel imgt:Product_e25f50c3-9b20-361d-9c46-198fe111366e|imgt:commun_name|MDX-CD4 imgt:Product_9f3b70a8-1ab1-357c-82db-a284346f9860|imgt:hasStudyProduct|imgt:StudyProduct_07fb2eda-c36b-3574-82a8-a0f6f9455cd5 imgt:Phosphorylcholine|skos:definition|Phosphorylcholine (ChoP) imgt:mAb_77|imgt:hasProduct|imgt:Product_4e8c6419-bb31-3dc4-81fe-a499fde05f03 imgt:Product_885d502e-12f5-381c-9601-6d157171b81e|imgt:isProducedBy|imgt:LeafBio_Inc imgt:Product_c4526586-07f1-3afc-81e7-ecabc79a2f1c|rdf:type|obo:NCIT_C51980 imgt:IgG1-lambda_946|rdfs:comment|IgG1 - lambda imgt:G-LIKE-DomainLabel|rdf:type|owl:Class imgt:Construct_140|obo:BFO_0000051|imgt:Segment_140_1 imgt:11464|rdfs:label|11464 imgt:Product_5afec3ec-290b-336b-a08f-33a38d788b45|imgt:hasStudyProduct|imgt:StudyProduct_e82fce6f-f9b1-3c8e-ba70-8a8f50d57e6f imgt:mAb_770|imgt:inn_number|10681 imgt:MedImmune|imgt:produces|imgt:Product_d688aa3b-aa3d-3d8e-9f4f-2f22e5a667f9 imgt:IgG4-kappa_1082|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG4-kappa.png _:B9982431bccc367c01fee5a2c99ec0586|imgt:isDecisionOf|imgt:StudyProduct_84943707-93aa-3f08-8787-9270eb6f179d imgt:Segment_71_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Clone_103|obo:RO_0002162|imgt:Musmus imgt:Construct_656|obo:BFO_0000051|imgt:Segment_656_1 imgt:mAb_368|imgt:hasProduct|imgt:Product_8924fb04-237b-37c3-b29a-712a10fcde39 imgt:VH-C-kappa-CH2-CH3_V-lambda-CH1_H-GAMMA-1_L-kappa_793|rdf:type|imgt:MAbReceptor imgt:StudyProduct_c933dab2-441a-3c14-b9e9-3453cb22aff9|imgt:hasDecision|_:Bf751eeac1d55e62bc05d2672ad73b8fa imgt:Product_2046a78d-ba5a-3908-949c-c2d69a5bb46a|imgt:hasStudyProduct|imgt:StudyProduct_f6d75078-902f-3510-b388-73b8e679bc42 imgt:StudyProduct_0584e143-d0b0-3644-8317-76cde6765c24|imgt:application_type|Therapeutic imgt:mAb_372|imgt:hasProduct|imgt:Product_788b3959-d5c8-36a5-9cf6-738181181b51 imgt:CD248|obo:RO_0002162|imgt:Homsap imgt:mAb_1266|imgt:inn_number|12041 imgt:Segment_851_1|imgt:hasImgtLabel|imgt:IgG4-kappa imgt:Product_9fe2aea9-6590-3730-92bb-c9b32d85d073|imgt:commun_name|PD-0805 imgt:StudyProduct_8699718e-7e34-3ebf-8b46-ef2ca12bacfc|rdfs:label|StudyProduct_8699718e-7e34-3ebf-8b46-ef2ca12bacfc imgt:Construct_1048|rdf:type|imgt:Construct imgt:Construct_1071|imgt:hasImgtLabel|imgt:IgG4-lambda imgt:StudyProduct_ff3ed28b-5382-3602-9a61-d06b879bf722|rdf:type|obo:NCIT_C174271 imgt:Segment_159_1|obo:BFO_0000050|imgt:Construct_159 imgt:Systemic_lupus_erythematosus_(SLE)|imgt:isClinicalIndicationOf|imgt:StudyProduct_6144f41f-4c54-3c4d-9c59-2a2174eb9b09 imgt:Product_0d23f5a7-b8cb-3eb8-ba07-41a57852fdf3|imgt:hasStudyProduct|imgt:StudyProduct_877034ef-cdfa-3d6f-a36c-87e6faef79ca imgt:IgG1-kappa_654|imgt:isMabReceptorOf|imgt:mAb_654 imgt:Segment_733_1|rdf:type|imgt:Segment imgt:Product_2a7ef046-f89a-3047-8fda-d01cd0060b8a|imgt:isProductOf|imgt:mAb_270 imgt:IgG4-kappa_948|imgt:isMabReceptorOf|imgt:mAb_948 obo:NCIT_C170384|rdf:type|owl:Class imgt:StudyProduct_0107ea9f-d05c-34ac-b762-624aeb45f424|imgt:hasClinicalIndication|imgt:Chronic_Hepatitis_C imgt:J-gene|imgt:hasConfigurationType|imgt:G imgt:StudyProduct_9ca532b7-4f84-3ca1-b57f-fff0036e4dd4|imgt:hasClinicalPhase|imgt:Phase_II imgt:Segment_690_1|rdf:type|imgt:Segment obo:NCIT_C67562|rdf:type|owl:Class imgt:Construct_284|rdf:type|imgt:Construct _:B58001b9560ca4acb2799f29da114009b|imgt:isDecisionOf|imgt:StudyProduct_f9ebad83-378a-39ab-9408-576c062cfcdf imgt:Segment_746_2|imgt:has_rank|2 _:Bb73867cc079e3ab87e7870354099e9e7|rdf:type|obo:NCIT_C53285 imgt:Amgen|imgt:produces|imgt:Product_97551870-12ac-39cb-a566-96ca9d85ebc5 imgt:Segment_895_1|rdfs:label|Segment_895_1 imgt:mAb_796|imgt:inn_proposed_list|118 (2017) imgt:IgG1-kappa_1039|http://semanticscience.org/resource/SIO_000291|imgt:KDR imgt:4JN2|rdfs:label|4JN2 imgt:Segment_270_1|rdfs:label|Segment_270_1 imgt:StudyProduct_97bd05c1-676a-3d1b-8ba2-d6d01d37957e|imgt:hasDecision|_:Bea823398c818e9170453fd4090d146a4 imgt:Product_d1ff3524-abf9-3a7a-93d3-8b514c80da83|rdf:type|obo:NCIT_C51980 imgt:Segment_950_1|rdfs:label|Segment_950_1 _:B9616153f5f7b630592b841e1e140ae35|imgt:hasStatut|imgt:approval imgt:StudyProduct_823c31f0-c5d8-3976-9843-0963a819e426|imgt:application_type|Therapeutic imgt:StudyProduct_85ff6d84-e374-3eee-ba39-81d6e0189482|imgt:hasClinicalIndication|imgt:Solid_tumors imgt:mAb_880|rdfs:label|mAb_880 obo:NCIT_C121538|rdf:type|owl:Class imgt:StudyProduct_94f5337b-0646-3463-9f19-8108acffa52d|rdf:type|obo:NCIT_C174271 imgt:Construct_672|rdfs:label|Construct_672 imgt:Taimed_Biologics_Inc|imgt:produces|imgt:Product_f4c1df4f-2677-3e9d-9741-4a08b92eb031 imgt:Amyotrophic_lateral_sclerosis_(ALS)|imgt:clinical_domain|Immunology imgt:Fc-Alpha|imgt:isDefinedBy|imgt:IG-Heavy-Alpha imgt:HOR-CTP_696|imgt:fused_with| CTP (C-terminal peptide of hCG) imgt:Construct_388|rdf:type|imgt:Construct imgt:Product_375c2e4e-3527-3271-b018-448b9ee8aba7|imgt:isProducedBy|imgt:Incyte_Corporation imgt:Cholangiocarcinoma|rdfs:label|Cholangiocarcinoma imgt:Systemic_lupus_erythematosus_(SLE)|rdfs:label|Systemic_lupus_erythematosus_(SLE) imgt:IgG1-kappa_381|imgt:hasMolecularComponent|imgt:IG imgt:Segment_499_1|obo:BFO_0000050|imgt:Construct_499 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imgt:StudyProduct_f1a2ac18-78f7-3354-a4a7-44240a5c9472|imgt:hasClinicalPhase|imgt:Phase_III imgt:KLB|rdf:type|obo:NCIT_C25702 imgt:Sichuan_Kelun-Biotech_Biopharmaceutical|rdf:type|obo:NCIT_C54131 imgt:Segment_701_3|imgt:hasImgtLabel|imgt:XTEN imgt:Product_bcb84be8-9b68-3e5c-9bd8-13ccd209f567|imgt:hasStudyProduct|imgt:StudyProduct_309cbdae-97a1-314b-83a0-f3f22f4b4747 _:Bc3ea9c123d427d84245148d9a6f47f7a|imgt:hasDesignation|imgt:Orphan_drug imgt:StudyProduct_dbd5a879-91a6-3fef-8a6a-6eb4819f1066|imgt:isStudyProductOf|imgt:Product_e5ca6245-7a11-3390-b7de-6b5e8870b2ab imgt:mAb_1023|rdfs:label|mAb_1023 imgt:StudyProduct_38d44c39-7af5-3adc-bd30-2bc14412d098|imgt:hasClinicalPhase|imgt:Phase_II imgt:Product_b2cc8073-23cf-353d-8ced-550f89677c37|imgt:isProductOf|imgt:mAb_957 imgt:L-IOTA-2|imgt:describes|imgt:IG-Light-Iota-2-IGI2 imgt:StudyProduct_e06ffe39-2f35-3f04-be74-5419cd3e8cbb|imgt:isStudyProductOf|imgt:Product_8dffe2b9-7350-3518-817c-92097f359d65 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imgt:CTAG1B_(cancer/testis_antigen_1B_NY-ESO-1_autoimmunogenic_cancer/testis_6.1_CT6.1_L_antigen_family_member_2_LAGE-2)-with_amino-terminal_fused_dipeptide_glycyl-prolyl_(GP)|rdf:type|imgt:ConstructLabels obo:NCIT_C152948|rdf:type|owl:Class imgt:Myocardial_infarction|imgt:isClinicalIndicationOf|imgt:StudyProduct_a394d410-8c86-3267-aadb-19f5cfc44f8e imgt:OPI_(Orphan_Pharma_International)|rdfs:comment|Dardilly , France imgt:ILDR2|rdf:type|obo:NCIT_C25702 imgt:mAb_749|imgt:clinical_trials|6 studies found, 2 recruiting imgt:Segment_11_1|rdfs:label|Segment_11_1 imgt:THPO_(thrombopoietin_megakaryocyte_growth_and_differentiation_factor_MPLLG_MPL_ligand_c-mpl_ligand_megakaryocyte_growth_and_development_factor_megakaryocyte_colony-stimulating_factor)_22-184_(P40225-1)|rdfs:label|THPO (thrombopoietin, megakaryocyte growth and differentiation factor, MPLLG, MPL ligand, c-mpl ligand, megakaryocyte growth and development factor, megakaryocyte colony-stimulating factor) 22-184 (P40225-1) imgt:Janssen_Research_&_Development_LLC|imgt:produces|imgt:Product_60bb6277-81d6-3efe-8951-bb967ff3ce28 imgt:Segment_1101_1|rdfs:label|Segment_1101_1 imgt:CTGF|rdf:type|obo:NCIT_C25702 imgt:Alpine_Immune_Sciences|rdfs:label|Alpine Immune Sciences imgt:Construct_755|rdf:type|imgt:Construct imgt:mAb_114|imgt:hasOriginClone|imgt:Clone_114 imgt:EGF-3|rdfs:label|EGF-3 imgt:mAb_790|imgt:inn_number|10387 imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_5a1ad1e9-3be1-3c12-9469-e6961e41c78a imgt:StudyProduct_4b2ceeb7-05d1-35b6-af06-0b36d91dc0fb|imgt:hasDecision|_:B571a4abf6f04e928f194da0fbbf71526 imgt:Segment_937_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Product_541b4ebc-3d0d-373d-b3df-953377514db9|imgt:hasStudyProduct|imgt:StudyProduct_419e028a-f1b2-380d-baa6-519c478a9ddb imgt:StudyProduct_8c392433-f79a-3598-bd21-e7d09a590193|imgt:application_type|Therapeutic imgt:IgG4-lambda|rdfs:label|IgG4 - lambda imgt:StudyProduct_49630eff-3c50-36c8-b562-6cd7a15dde73|imgt:application_type|Therapeutic imgt:StudyProduct_735319b1-25b9-3224-8bba-19ee5b4fd700|imgt:hasClinicalIndication|imgt:T_cell_lymphoma imgt:Construct_425|imgt:isConstructOf|imgt:IgG1-kappa_425 obo:NCIT_C158436|rdf:type|owl:Class imgt:Product_823dd5e7-e3e3-3909-90c0-6b381ca01691|imgt:isProductOf|imgt:mAb_1297 imgt:IgG1-kappa_MM_269|imgt:conjugated_with| chelator cituxetan imgt:IgG1-kappa_232|imgt:hasMolecularComponent|imgt:IG imgt:Clone_559|rdfs:label|Clone_559 imgt:StudyProduct_51d86a23-4cb4-3676-968e-488d0835771a|imgt:hasDecision|_:B7c489fd74d1e5f1e3af9a114fd6928a4 _:Be0bdf5dade1d2f2e0f211d7255deded4|imgt:hasDesignation|imgt:Orphan_drug imgt:Cytomegalovirus_(CMV)_retinitis_in_HIV_individuals|imgt:isClinicalIndicationOf|imgt:StudyProduct_63bd63f0-1c52-3759-9c53-b9217732b250 imgt:mAb_729|imgt:hasMabReceptor|imgt:IgG1-lambda_729 imgt:Mentrik_Biotech|rdfs:comment|Dallas , USA imgt:mAb_119|imgt:imgt_note| Goldberg R.M. Lessons learned from the edrecolomab story: how a checkered past became a checkered flag for monoclonal antibodies in colorectal cancer therapy. Onkologie 28:311-312 (2005). In IMGT/2Dstructure-DB, only potential sequences for the variable domains are available in #7471 imgt:ImmunoGen_Inc|imgt:produces|imgt:Product_010eb41e-d503-390b-825c-4077f0fe83bd imgt:mAb_393|imgt:imgt_note| MOA: effect analog to THPO (thrombopoeitin) romiplostim, a Fc-peptide fusion protein, is a thrombopoietin receptor agonist. It belongs to the thrombopoietin (TPO) mimetic class, although the peptides have no homology with TPO. By binding to the thrombopoietin receptor (MPL, CD110), it activates the differentiation of the megacaryocytes and therefore increases the platelet production. Romiplostim is a thrombopoietin mimetic Fc-fusion peptide. The sequences of the peptides are different from the natural ligand THPO (thrombopoietin, megakaryocyte growth and differentiation factor, MPLLG, MPL ligand, c-mpl ligand, megakaryocyte growth and development factor, megakaryocyte colony-stimulating factor). \r Romiplostim binds and activates MPL (thrombopoietin receptor, myeloproliferative leukemia virus oncogene, MPL proto-oncogene, TPOR, CD110) and stimulates JAK2 (Janus kinase 2) and STAT5A (signal transducer and activator of transcription 5A) pathways. This leads to megakaryocyte proliferation and differentiation. Megakaryocytes then extend protrusions (proplatelets) into the bone marrow blood vessels. Sheer stress from blood flow fragments the protrusions, creating platelets. imgt:Product_5de6a99e-dedd-3ea1-be46-1a994fd0890e|imgt:hasStudyProduct|imgt:StudyProduct_be02faf8-e597-34bc-9ffc-4f885877877a imgt:Segment_546_2|rdfs:label|Segment_546_2 imgt:CD19|imgt:isTargetOf|imgt:scFv-kappa-heavy-scFv-kappa-heavy-CD4(CO-TM-CY)_1232 imgt:StudyProduct_7b3742d7-bcb4-3f36-a556-e5759a2f156f|imgt:hasClinicalIndication|imgt:Septic_shock_MSS_(meningococcal_septic_shock) imgt:IgM-kappa_129|rdfs:comment|IgM - kappa imgt:mAb_468|rdfs:label|mAb_468 imgt:StudyProduct_1833d0a8-c298-3a28-a897-c4ea51020252|imgt:isStudyProductOf|imgt:Product_1e3e70cb-9c74-352f-bc15-c39c41590fbc imgt:Sanofi|imgt:produces|imgt:Product_92683334-b9aa-397f-afad-ef30225a0323 imgt:mAb_236|imgt:inn_recommended_list|61 (2009) imgt:CYTOPLASMIC-REGION|skos:definition|coding intracytoplasmic region of C-GENE-UNIT, GENE-UNIT or L-GENE-UNIT, in spliced cDNA or in artificially spliced gDNA imgt:Product_fe170d32-2e79-37f8-b44b-a495e80a927a|imgt:hasStudyProduct|imgt:StudyProduct_5ff62102-e848-3f73-a032-36953e1cfc52 imgt:Construct_844|imgt:isConstructOf|imgt:IgG1-lambda_844 imgt:mAb_217|imgt:hasImgtStructureEntry|imgt:8750 imgt:PROTEIN_1DOMAIN-PEG_1299|imgt:isMabReceptorOf|imgt:mAb_1299 imgt:Product_2a7ef046-f89a-3047-8fda-d01cd0060b8a|rdf:type|obo:NCIT_C51980 imgt:Product_d3b3ee2c-a59b-36a5-a62a-c351fa3e366e|rdf:type|obo:NCIT_C51980 imgt:scFv-PROTEIN-scFv_546|http://semanticscience.org/resource/SIO_000291|imgt:ERBB2 imgt:StudyProduct_4c23fda2-e0e0-3183-b219-38ccf5fe3866|imgt:hasClinicalPhase|imgt:Phase_I imgt:StudyProduct_3b05e51f-a753-36a4-8c40-4bc1472d53d5|imgt:hasClinicalIndication|imgt:Liver_transplantation imgt:MS4A1|imgt:isTargetOf|imgt:IgG1-kappa_161 imgt:Cancers_ovarian|imgt:isClinicalIndicationOf|imgt:StudyProduct_608de4f2-5325-32d0-8f68-c3fd942fe4a3 _:Be8edbb9054997db3b9f4292403882fc1|imgt:isDecisionOf|imgt:StudyProduct_55c816e6-6674-30da-bbf5-afa89cd5618b imgt:Construct_671|obo:BFO_0000051|imgt:Segment_671_1 imgt:StudyProduct_b063c60c-7c3d-3aac-92b4-c8661305b3be|imgt:hasClinicalPhase|imgt:Phase_II imgt:CR1_(Pr164-234)|rdf:type|imgt:RPILabel imgt:mAb_525|rdf:type|obo:NCIT_C64779 imgt:IgG1-kappa-4cys-drug_1269|rdfs:comment|IgG1 - kappa - 4cys - drug imgt:Multiple_myeloma_(MM)|imgt:isClinicalIndicationOf|imgt:StudyProduct_e5f9bc32-80ee-33ea-9c6d-c28d60583c72 imgt:Segment_437_1|rdf:type|imgt:Segment imgt:Product_785b96d0-9949-370c-8ff7-5e6014018922|imgt:commun_name|TNX-901 obo:NCIT_C175808|rdfs:subClassOf|obo:NCIT_C1909 imgt:mAb_1000|rdf:type|imgt:INN imgt:Lymphoma_primary_mediastinal_B_cell_(PMBL)|imgt:isClinicalIndicationOf|imgt:StudyProduct_50d40cdb-5c10-3536-957a-9803d78451f5 imgt:SARS-CoV-2|skos:definition|Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2) imgt:Product_a461e569-39a0-3c1c-8ef1-e32c2837aaa7|imgt:isProducedBy|imgt:Regeneron_Pharmaceuticals_Inc imgt:%5B(scFv-heavy-kappa)-IGHE-CH4%5D2|rdfs:label|[(scFv - heavy - kappa) - IGHE - CH4]2 imgt:StudyProduct_6b612b11-5933-3c77-871a-d835dd207209|imgt:hasDecision|_:Bbe7ec607f67369536d676242fd86b879 imgt:StudyProduct_bf5eb408-cd4f-368d-9967-1230c1d1e925|imgt:hasClinicalPhase|imgt:Phase_I/II imgt:_Sp2/0_mouse_hybridoma_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_9f935236-2a5a-3f74-83e3-551ae2020862 imgt:Product_8e4f31af-8bb6-303e-b57e-d15ba5bd4075|imgt:commun_name|BMS986413 imgt:Product_60d67764-c42e-3595-b0ea-20f088fd5134|imgt:hasStudyProduct|imgt:StudyProduct_735319b1-25b9-3224-8bba-19ee5b4fd700 imgt:Severe_acute_respiratory_syndrome_coronavirus_2_(SARS-CoV-2)_infection_(COVID-19)|imgt:isClinicalIndicationOf|imgt:StudyProduct_32077acd-765d-3532-9668-00e229d622c8 imgt:StudyProduct_e6fe1e0b-d794-30a4-9c92-0a5f8a391919|imgt:isStudyProductOf|imgt:Product_6942fb15-771a-33c8-bb83-07688b78a15b imgt:Construct_1019|rdfs:label|Construct_1019 imgt:11947|rdf:type|obo:NCIT_C25402 imgt:Product_5dde1122-ca49-3ad6-8e30-d28049e1461d|imgt:commun_name|adnectin imgt:H-GAMMA-1-IDUA|rdfs:label|H-GAMMA-1-IDUA pubmed:16796401|rdfs:label|PMID_16796401 imgt:Construct_749|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Segment_67_1|imgt:has_rank|1 imgt:KDR|imgt:isTargetOf|imgt:IgG1-kappa_1194 imgt:StudyProduct_a65d783c-20d7-3c58-a5b8-dff0787e156c|imgt:hasClinicalPhase|imgt:Phase_M imgt:mAb_336|imgt:hasMabReceptor|imgt:IgG1-kappa_336 imgt:StudyProduct_c86b5462-bd99-3ee6-b478-75c86ccb1635|imgt:hasClinicalPhase|imgt:Phase_I imgt:Product_76a068f8-e304-3746-aabc-b40c1b23f548|rdf:type|obo:NCIT_C51980 imgt:StudyProduct_b70513a8-0baa-3a75-ab83-97c07e45443a|imgt:development_technology| Cambridge Antibody Technology (CAT) human antibody phage display library imgt:CONNECTING-REGION|skos:definition|coding region connecting the membrane proximal C domain (C-DOMAIN or C-LIKE-DOMAIN) and the TRANSMEMBRANE-REGION of C-GENE-UNIT, GENE-UNIT or L-GENE-UNIT, in spliced cDNA or in artificially spliced gDNA. The CONNECTING-REGION in spliced cDNA is delimited with one additional nucleotide in 5' (= the most 3' of the preceding exon) to obtain a first complete exon (sf1) imgt:mAb_383|imgt:hasMabReceptor|imgt:IgG1-kappa_383 imgt:mAb_671|imgt:imgt_note| Chiron Corporation was an American multinational biotechnology firm based in Emeryville, California that was acquired by Novartis International AG on April 20, 2006. imgt:IgG1-kappa_MM_225|rdfs:label|IgG1-kappa_MM_225 imgt:Cancers_ovarian|imgt:isClinicalIndicationOf|imgt:StudyProduct_a178c7f1-ecfc-3ab2-9391-59c5f850342c imgt:StudyProduct_7e33aa3f-6f4e-3b97-9866-e6b5181831a3|rdf:type|obo:NCIT_C174271 imgt:Product_a767bffc-a297-39f0-a375-f95be362b9e7|imgt:isProductOf|imgt:mAb_918 imgt:StudyProduct_47c83720-4471-39cc-b0d4-0aa7d46fe8da|imgt:hasClinicalIndication|imgt:Congenital_hyperinsulinism_(CHI) imgt:V-LAMBDA-CH1|rdf:type|imgt:ChainLabels imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_f50ee431-70f4-33e4-8ada-f65929afb9ef obo:NCIT_C170346|rdfs:subClassOf|obo:NCIT_C1909 imgt:StudyProduct_a4727270-51a2-39ad-a4c3-e1c0fa7af61a|imgt:hasClinicalIndication|imgt:Colitis_ulcerative_(UC) imgt:Segment_792_1|imgt:hasImgtLabel|imgt:IgG1-lambda imgt:Product_77b1d31f-8986-3dd9-86b7-51b56818e7a2|imgt:isProducedBy|imgt:Celltech_UCB imgt:Product_87376b34-c995-367f-9c8c-6b74e4f5097b|imgt:isProducedBy|imgt:DiNonA_Co_Ltd imgt:Clone_217|rdfs:label|Clone_217 imgt:StudyProduct_33f0c871-917c-343e-a485-18b51d0b2bb4|imgt:application_type|Therapeutic imgt:mAb_179|imgt:imgt_note| ImClone Systems became a wholly-owned subsidiary of Eli Lilly and Company on November 24, 2008. Press release imgt:Age-related_macular_degeneration_(AMD)_geographic_atropy_(GA)_(dry_advanced_form)|imgt:isClinicalIndicationOf|imgt:StudyProduct_0b2dd449-a8d5-3155-b6ea-d97309491c6a imgt:mAb_618|imgt:hasProduct|imgt:Product_372d02b4-b16a-3ff3-89fa-2a311590437e _:B5cb12e48d98a9213059c2cd1746df007|imgt:hasStatut|imgt:approval imgt:StudyProduct_332ed26b-007f-3cdb-b618-a362512d9730|imgt:hasClinicalPhase|imgt:Phase_M imgt:Non-Hodgkin's_lymphoma_(NHL)_follicular_CD20_positive_relapsed_or_refractory_low_grade|imgt:isClinicalIndicationOf|imgt:StudyProduct_d8bb306f-3e8b-3b02-a6fd-7a1446b05de5 imgt:Segment_589_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:IgG2-kappa_293|imgt:hasMolecularComponent|imgt:IG imgt:Segment_819_2|imgt:hasImgtLabel|imgt:IGHG4 imgt:PEPTIDE-PROTEIN_1292|http://semanticscience.org/resource/SIO_000291|imgt:Protein_substitute imgt:StudyProduct_abc3c266-379b-3ea9-9dc9-1980481db404|rdf:type|obo:NCIT_C174271 imgt:Product_6070f2ac-d903-337d-beab-a7ca53d7c933|imgt:isProducedBy|imgt:Genentech_Inc imgt:Product_b040dae5-3608-32e1-b3f2-9802ffb17c21|rdfs:label|Product_b040dae5-3608-32e1-b3f2-9802ffb17c21 imgt:mAb_946|imgt:inn_number|11107 imgt:Allakos_Inc|rdf:type|obo:NCIT_C54131 imgt:Product_f4c1df4f-2677-3e9d-9741-4a08b92eb031|imgt:commun_name|TMB355 imgt:Construct_1160|rdf:type|imgt:Construct imgt:IgG2-kappa_116|imgt:hasMolecularComponent|imgt:IG imgt:mAb_357|imgt:inn_number|9295 imgt:Product_b14b8aa8-e5fd-36c2-a182-be2c0d32c945|imgt:isProductOf|imgt:mAb_88 imgt:StudyProduct_eecf5ce4-fbe7-3768-b545-33e1eb7be4a0|imgt:hasClinicalIndication|imgt:Age-related_macular_degeneration_(AMD)_neovascular_(wet) imgt:Product_e521e71e-0d27-3157-a807-f8780c379245|imgt:commun_name|MRA imgt:Product_9515173d-a62b-3801-8bd7-de87e171e906|imgt:isProducedBy|imgt:OraVax_Inc imgt:mAb_102|rdf:type|obo:NCIT_C97945 imgt:Segment_275_1|rdfs:label|Segment_275_1 obo:NCIT_C121625|rdfs:subClassOf|obo:NCIT_C1909 imgt:HIV-1|rdfs:label|HIV-1 imgt:Product_f1256184-14be-352c-97bb-4a84a7bea8e0|imgt:commun_name|HuZAF imgt:Product_07efa5a7-6da0-33c5-ab78-e24bf8289225|imgt:commun_name|AMG 181 imgt:StudyProduct_3e0a6029-f7fb-3cc4-b507-166eb0790d1f|rdfs:label|StudyProduct_3e0a6029-f7fb-3cc4-b507-166eb0790d1f imgt:mAb_397|rdfs:label|mAb_397 imgt:CLASSIFICATION|owl:disjointWith|imgt:IDENTIFICATION imgt:Severe_acute_respiratory_syndrome_(SARS)_infection|imgt:clinical_domain|Infectiology imgt:StudyProduct_29f41476-00a9-3c6c-9001-d450314ddf97|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_2d924b80-9cd2-391c-9954-1ac1206ab109|imgt:hasClinicalPhase|imgt:Phase_M imgt:Product_b12ab81c-147d-34f3-aa01-f95e94eb88de|imgt:isProductOf|imgt:mAb_1038 imgt:StudyProduct_d21fbd7e-727a-3e75-8765-e89276b143ab|imgt:isStudyProductOf|imgt:Product_ad630571-be3a-37d0-b30d-5b4667c2c49a imgt:Construct_295|imgt:isConstructOf|imgt:IgG1-kappa_295 imgt:mAb_1225|rdf:type|imgt:INN imgt:Construct_423|imgt:isConstructOf|imgt:IgG4-kappa_423 imgt:StudyProduct_794808d5-60bc-384d-80e6-99686e844d7c|imgt:application_type|Therapeutic imgt:Product_1a2d7afe-fb0d-33fe-9798-879a917f9548|imgt:isProductOf|imgt:mAb_1094 imgt:mAb_499|imgt:hasMabReceptor|imgt:V-kappa-PEG-PEG_499 imgt:CONVENTIONAL-GENE|rdfs:label|CONVENTIONAL-GENE imgt:Construct_1173|rdfs:label|Construct_1173 imgt:Genzyme_Corp|rdfs:label|Genzyme Corp. obo:NCIT_C124999|rdfs:subClassOf|obo:NCIT_C1909 imgt:IgG1-nd_40|http://semanticscience.org/resource/SIO_000291|imgt:CD22 imgt:IgG1-kappa_907|rdfs:comment|IgG1 - kappa imgt:Toxin|skos:definition|toxin of crynebacterium diphtheriae imgt:1ZA6|imgt:isImgtStructureEntryOf|imgt:mAb_29 imgt:mAb_722|imgt:hasMabReceptor|imgt:IgG1-kappa-8cys-drug_722 imgt:mAb_587|imgt:inn_proposed_list|114 (2015) imgt:StudyProduct_b5d3394f-e7b8-36c2-ade9-39e65a0dd3db|imgt:hasClinicalPhase|imgt:Phase_II imgt:IgG1-kappa_502|rdfs:label|IgG1-kappa_502 imgt:IgG1-lambda-3lys-drug_575|rdf:type|imgt:MAbReceptor imgt:IgG1-kappa_965|rdfs:comment|IgG1 - kappa imgt:StudyProduct_4c297422-ee66-3012-88ea-315e69f171c0|imgt:hasClinicalPhase|imgt:Phase_M imgt:StudyProduct_88292b86-7a14-37c5-9681-001550cab8be|rdfs:label|StudyProduct_88292b86-7a14-37c5-9681-001550cab8be imgt:IgG1-kappa_1185|imgt:hasMolecularComponent|imgt:IG imgt:StudyProduct_95dd2585-8bee-30e2-8c5c-e42a828f78ce|imgt:hasExpressionSystem|imgt:_CHO_DG44_(Chinese_Hamster_Ovary)_cells imgt:IgG1-kappa_1250|rdf:type|imgt:MAbReceptor imgt:Cancers_breast_metastatic|rdf:type|obo:NCIT_C185637 imgt:mAb_121|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=121 imgt:IgG4-kappa_1037|http://semanticscience.org/resource/SIO_000291|imgt:CD47 imgt:mAb_247|imgt:hasImgtStructureEntry|imgt:8627 imgt:mAb_1222|rdfs:label|mAb_1222 imgt:Pfizer|imgt:produces|imgt:Product_8281a068-f894-3608-8a65-2649dfe666a9 imgt:Construct_939|imgt:isConstructOf|imgt:IgG2-kappa_939 _:Bc91fc90a5b50a13a8535d7d3f6716ae8|imgt:isDecidedBy|imgt:EMA _:B954606fe400c658bc3ceefa68ebffff8|imgt:hasDesignation|imgt:Orphan_drug imgt:IgG2-kappa_1170|imgt:hasMolecularComponent|imgt:IG imgt:Thrombotic_thrombocytopenia_purpura_(TTP)_acquired|rdf:type|obo:NCIT_C185637 imgt:Acute_lymphocytic_leukemia_(ALL)|imgt:isClinicalIndicationOf|imgt:StudyProduct_f8da3f77-3733-32fd-b4fc-d5ef2bae5cfb imgt:Product_6521ccf6-a005-3cb9-9946-f492ecfeb639|imgt:hasStudyProduct|imgt:StudyProduct_643fb5f4-6997-38c7-9b26-e1caa4491330 imgt:Cancers|imgt:isClinicalIndicationOf|imgt:StudyProduct_c9b26fdc-0c61-338f-8e80-c446ecc312fe imgt:Clone_226|rdf:type|obo:NCIT_C37925 imgt:PROTEIN_1DOMAIN_708|rdf:type|imgt:MAbReceptor imgt:mAb_1187|rdf:type|obo:NCIT_C99123 imgt:StudyProduct_6d87d57d-9799-326e-aa32-a570c9033bac|imgt:isStudyProductOf|imgt:Product_bfe2fe91-b07e-31f5-bde7-34f768c8f3f3 imgt:StudyProduct_988f16a7-b509-3d22-868d-d5da13250685|imgt:hasClinicalPhase|imgt:Phase_I imgt:Construct_1187|imgt:isConstructOf|imgt:IgG4-kappa_1187 _:Bf861a4ab8dddc6a38ff1cdb522686aba|rdf:type|obo:NCIT_C53285 imgt:TNFRSF13C|obo:RO_0002162|imgt:Homsap imgt:mAb_726|imgt:hasMabReceptor|imgt:IgG1-kappa_726 imgt:Fab%27-G2a-kappa_306|rdf:type|imgt:MAbReceptor imgt:mAb_333|imgt:hasProduct|imgt:Product_01f3c901-db8e-305c-8b01-2789aa0434c1 imgt:LAG3|skos:definition|LAG3 (lymphocyte activating 3, lymphocyte-activation 3, CD223) imgt:StudyProduct_4b230915-2f77-3da9-ad24-3c19c348430f|rdf:type|obo:NCIT_C174271 imgt:mAb_640|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=640 imgt:J-sequence|rdf:type|imgt:Molecule_EntityType imgt:StudyProduct_94f5337b-0646-3463-9f19-8108acffa52d|imgt:application_type|Therapeutic imgt:StudyProduct_bfb2e54a-e89b-3b48-b84d-cdbd91007b2d|imgt:isStudyProductOf|imgt:Product_4391f6b4-98b1-38e2-94d2-967326f820fe imgt:IgG2-kappa_1202|rdfs:label|IgG2-kappa_1202 imgt:StudyProduct_dbc35ff8-1e6e-3381-8154-ed33e47dc52d|rdfs:label|StudyProduct_dbc35ff8-1e6e-3381-8154-ed33e47dc52d imgt:Crohn's_disease_(CD)|imgt:isClinicalIndicationOf|imgt:StudyProduct_3d3b1b00-4296-3c01-9e34-6a5b725dbe90 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imgt:PROTEIN_1DOMAIN-PEG_637|imgt:hasConstruct|imgt:Construct_637 imgt:mAb_717|imgt:inn_name|frunevetmab imgt:StudyProduct_0c2e289e-0371-3b3e-b7e2-40c276bbb416|imgt:hasClinicalPhase|imgt:Phase_I imgt:mAb_1052|imgt:inn_name|ledelabricin alfa imgt:IG-Heavy-Alpha|imgt:defines|imgt:IgA_Kappa imgt:Clone_274|imgt:clone_name|KM-641 (IgG3) imgt:mAb_1114|rdfs:label|mAb_1114 pubmed:7937713|dc:title|Humanization of 60.3, an anti-CD18 antibody; importance of the L2 loop. imgt:Segment_1257_1|obo:BFO_0000050|imgt:Construct_1257 imgt:Product_ae524b04-99c4-38a9-90a9-969c902b7d04|rdf:type|obo:NCIT_C51980 imgt:EGFL7|imgt:isTargetOf|imgt:IgG1-kappa_427 imgt:Product_5038f9ea-65d4-3eb8-b074-e25dab59e6c5|rdf:type|obo:NCIT_C51980 imgt:Cancers_prostate|imgt:isClinicalIndicationOf|imgt:StudyProduct_155a9067-b940-3fed-b7cc-27c6460913bb obo:NCIT_C80038|rdfs:subClassOf|obo:NCIT_C1909 imgt:Product_362c36a5-0d9f-32a2-944c-5cf8f9c56f68|rdf:type|obo:NCIT_C51980 imgt:mAb_532|imgt:inn_number|10033 imgt:IgG1-kappa-2cys-drug_959|http://semanticscience.org/resource/SIO_000291|imgt:CD276 imgt:Clone_147|rdfs:label|Clone_147 imgt:StudyProduct_367eb35a-3f79-3cce-9549-59f69797c5e0|imgt:hasClinicalIndication|imgt:Diabetes_mellitus_(DM) imgt:StudyProduct_50e9635b-a1da-3a13-bd40-082697af1c76|rdf:type|obo:NCIT_C174271 imgt:9723|imgt:isImgtStructureEntryOf|imgt:mAb_459 imgt:HGNC_link|skos:definition|link to HGNC (Human Genome Organization (HUGO) Nomenclature Committee) imgt:mAb_317|rdf:type|imgt:INN imgt:Construct_1214|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Segment_744_1|rdfs:label|Segment_744_1 imgt:Product_538ab0c9-c52c-3c61-ae4c-1c89532b23a7|imgt:isProductOf|imgt:mAb_97 imgt:F(AB')2-GAMMA-2-A_LAMBDA|imgt:describes|imgt:F(ab’)2-Gamma-2-a_Lambda imgt:Wnt_ligands|skos:definition|Wnt ligands imgt:StudyProduct_bb050277-acb5-3c72-ad0f-0f86e2867b02|rdf:type|obo:NCIT_C174271 imgt:mAb_539|imgt:inn_name|isatuximab imgt:StudyProduct_acb91568-6d59-3391-b836-4a871624d002|imgt:hasDecision|_:B8611164b7e4e98463264a4bc1c00e297 imgt:mAb_74|imgt:hasProduct|imgt:Product_e8616ca0-4a3d-34d5-9d8f-312766b99786 imgt:mAb_723|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=723 imgt:mAb_291|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=291 imgt:Synthetic_Biologics_Inc|imgt:produces|imgt:Product_bb842732-4cc6-3670-99b1-2dc2863e673d imgt:Product_9e85a06f-cc89-31ca-b689-1be2820b0536|imgt:commun_name|BMS-734016 imgt:Pain_chronic|imgt:isClinicalIndicationOf|imgt:StudyProduct_49da4a97-7e26-3138-8135-9bd4fc348fd1 imgt:StudyProduct_849db2fa-5569-30bf-9299-feb6f251a154|imgt:hasClinicalPhase|imgt:Phase_II imgt:Cancers|imgt:isClinicalIndicationOf|imgt:StudyProduct_742c2b4e-d0c6-31a4-8553-8114c3e14529 imgt:Segment_633_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Product_ab1469c5-6914-33ba-a094-bef28a95f7f3|imgt:commun_name|UCB4144 imgt:9074|rdf:type|obo:NCIT_C25402 imgt:Segment_507_1|rdfs:label|Segment_507_1 imgt:Segment_230_1|imgt:has_rank|1 imgt:mAb_1146|imgt:hasMabReceptor|imgt:IgG1-kappa_1146 imgt:mAb_719|rdf:type|imgt:INN imgt:mAb_705|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=705 imgt:TR-GAMMA-2_DELTA|imgt:describes|imgt:TR-Gamma-2_Delta imgt:Construct_1263|rdf:type|imgt:Construct imgt:StudyProduct_5aaf2721-67bc-315b-8810-084f9246df86|imgt:hasDecision|_:B3a3ec349b62de95cef646d7e79761613 imgt:Segment_1240_1|rdf:type|imgt:Segment obo:NCIT_C175797|rdfs:subClassOf|obo:NCIT_C1909 imgt:Construct_677|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:isLocusLocationTypeOf|rdfs:domain|imgt:LocusLocationType imgt:IgG1-kappa-2cys-CH3_879|http://semanticscience.org/resource/SIO_000291|imgt:IL3RA imgt:StudyProduct_d7f19d8a-4189-35e7-a73c-23e92d344117|imgt:application_type|Therapeutic imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_c47859a9-7323-3b02-9b97-441848f91191 imgt:10791|rdfs:label|10791 _:B4b2891488252da3269024f1c01c8234f|dc:date|2005-07-11 imgt:Product_8bdb3425-f72a-3777-be41-82fdaed26099|imgt:isProducedBy|imgt:MedImmune imgt:Construct_308|obo:BFO_0000051|imgt:Segment_308_1 imgt:IgG1-kappa_1141|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:StudyProduct_337c97f1-fee5-35a1-a552-4d1e6dcc3d63|imgt:application_type|Therapeutic imgt:Segment_730_2|rdf:type|imgt:Segment imgt:mAb_636|imgt:imgt_note| Type III interferon. imgt:Construct_596|imgt:isConstructOf|imgt:Fab%27-G1-kappa_596 imgt:Solid_tumors|imgt:isClinicalIndicationOf|imgt:StudyProduct_4c4b7899-8942-3476-8599-6a420c003c3a obo:NCIT_C174672|rdfs:subClassOf|obo:NCIT_C1909 imgt:mAb_1026|imgt:hasProduct|imgt:Product_d20d5641-8781-3f8c-9a35-3836a5995abc imgt:Product_251879e5-8c72-335f-89ef-7f76ad06fea2|imgt:isProductOf|imgt:mAb_645 imgt:StudyProduct_024b4b67-b3a6-3886-a04b-f0a3feef3807|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_0b9b180b-365a-3d5d-9ff6-ab0449929fca|imgt:hasClinicalIndication|imgt:Systemic_lupus_erythematosus_(SLE) imgt:AbGenomics_International_Inc|imgt:produces|imgt:Product_2155a726-3d06-3867-beba-3c3ffc3763ac imgt:mAb_218|imgt:atc_link|http://www.whocc.no/atc_ddd_index/?code=L01XC09 imgt:mAb_1216|imgt:hasProduct|imgt:Product_c4c827f8-eb1f-3253-8d37-f5b1a1d56ac7 imgt:IgG1-kappa_788|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:mAb_171|rdf:type|obo:NCIT_C152710 imgt:mAb_547|imgt:hasProduct|imgt:Product_4e4ab0ff-b8e5-3715-8f65-3904933d179e imgt:CARsgen_Therapeutics|rdfs:comment|Shanghai , China imgt:Segment_694_2|imgt:segment_detail|25-609 _:B2df5898b6be90aa6666e0742921b8017|rdf:type|obo:NCIT_C53285 imgt:V-D-J-C-chain|protege:protege#subclassesDisjoint|true imgt:mAb_165|imgt:inn_recommended_list|44 (2000) imgt:Fab-G1-kappa_901|obo:RO_0002162|imgt:Hum imgt:StudyProduct_a1b9a129-59be-3640-8abe-e26dd946e3c0|imgt:application_type|Therapeutic imgt:Construct_797|rdf:type|imgt:Construct imgt:Product_166b2758-4ccb-3e25-b5d9-61631837270f|imgt:commun_name|(Gly2)glp-2, Glucagon-like peptide ii (2-glycine) (human) imgt:%5BTNFRSF1B_(tumor_necrosis_factor_receptor_(TNFR)_superfamily_member_1B_TNFBR_p75_CD120b)%5D2-IGHG1_Fc_(Fragment_constant)|rdf:type|imgt:ConstructLabels imgt:mAb_1093|imgt:inn_proposed_list|123 (2020) imgt:GH1_(growth_hormone_1_somatotropin_GH_GH-N_GHN_hGH-N_pituitary_growth_hormone)-CTP_(C-terminal_peptide_of_the_β-subunit_of_human_chorionic_gonadotropin_(hCG))|rdf:type|imgt:ConstructLabels imgt:Hairy_cell_leukemia_(HCL)|imgt:isClinicalIndicationOf|imgt:StudyProduct_f8872358-c5ae-3d19-aa7e-89ec0f830df2 imgt:StudyProduct_5ad138eb-1b7c-3b50-a0f2-f5dfad6021a6|imgt:application_type|Therapeutic imgt:StudyProduct_e66b4ba4-8439-37c2-b264-1a3a6aeac91f|rdfs:label|StudyProduct_e66b4ba4-8439-37c2-b264-1a3a6aeac91f 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imgt:Neoplasms|imgt:isClinicalIndicationOf|imgt:StudyProduct_0baedbe6-1604-34c0-94ab-a794447ae333 _:B4281005899d54b45c8be1ebc1b3f4393|rdf:type|obo:NCIT_C53285 imgt:mAb_695|imgt:inn_proposed_list|77 (1997) imgt:IgG1-nd_MM_309|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-nd_MM.png imgt:Regeneron_Pharmaceuticals_Inc|imgt:produces|imgt:Product_84a2dc5c-f110-3334-bc8a-686353a3e2f3 _:B261109ae9fcd2e395c1a283e3f4e132e|rdf:type|obo:NCIT_C53285 imgt:PROTEIN_2DOMAINS_2F_278|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/PROTEIN_2DOMAINS_2F.png imgt:StudyProduct_2fdf0265-3f28-3adf-8b07-7ab12e193b1f|imgt:hasClinicalIndication|imgt:Rheumatoid_arthritis_(RA) _:B740865473acdfef0cd54ef1598485944|imgt:hasDesignation|imgt:Orphan_drug imgt:F(ab’)2-Delta_Lambda|imgt:isDefinedBy|imgt:IG-Light-Lambda-IGL imgt:mAb_1072|imgt:inn_proposed_list|123 (2020) 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imgt:Product_f01e8205-2d54-3f91-849d-e8708ee470b7|imgt:hasStudyProduct|imgt:StudyProduct_733eed86-fad6-30b9-b886-0b1fc85af195 imgt:mAb_1095|rdf:type|obo:NCIT_C156490 imgt:Cardiomyopathy_associated_with_dystrophinopathies|rdfs:label|Cardiomyopathy_associated_with_dystrophinopathies imgt:ganglioside_GD2_(disialoganglioside_GD2)|imgt:isTargetOf|imgt:IgG3-nd_70 imgt:Carcinoma_urothelial|rdfs:label|Carcinoma_urothelial imgt:Product_0018ff01-a960-34f5-a962-6894cb73438e|imgt:isProducedBy|imgt:Singh_biotechnology imgt:IL5RA|imgt:isTargetOf|imgt:IgG1-kappa_334 pubmed:7594506|dc:contributor|Guyre P.M. imgt:StudyProduct_d6603759-fe6a-3cb2-bdef-285ef9c6777e|imgt:isStudyProductOf|imgt:Product_b6db4dcb-3841-3302-afce-13d1e43b067e imgt:StudyProduct_25835666-f627-3743-aa83-e8ff38e5106a|imgt:hasDecision|_:B85af6548c4a2baf99b8b7f5390c99d3f imgt:mAb_1010|imgt:hasImgtStructureEntry|imgt:11311 imgt:Product_0517e477-c651-3706-be63-d3b291cef5f7|imgt:isProductOf|imgt:mAb_498 imgt:mAb_888|rdfs:label|mAb_888 imgt:StudyProduct_3f9bd427-1ccd-3281-9c05-1b70fead3c8d|imgt:hasClinicalIndication|imgt:Carcinoma_bladder_cancer_advanced_or_metastatic_urothelial_cancers imgt:StudyProduct_ba900ffd-ff21-33e4-bbef-8eaace304b8b|imgt:hasDecision|_:B6558d19e22917da1d00051ea042f3ee1 imgt:Segment_795_1|rdfs:label|Segment_795_1 imgt:mAb_952|rdf:type|imgt:INN imgt:mAb_874|rdfs:label|mAb_874 _:B4cc13ea090d1d004fb1c63fb7b02fa56|imgt:hasStatut|imgt:approval imgt:Product_f2202260-1eb1-3ea7-b7bb-a7ab1d7930ea|imgt:hasStudyProduct|imgt:StudyProduct_3c33cf64-59ff-3621-8d4f-95a3d85afee6 imgt:IgG4-nd_182|obo:RO_0002162|imgt:Homsap imgt:Segment_269_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:mAb_735|imgt:inn_number|10997 imgt:KLKB1|skos:definition|KLKB1 (kallikrein B1, kallikrein B, plasma (Fletcher factor) 1, KLK3, Fletcher factor) imgt:J-C-CLUSTER|skos:definition|genomic DNA of an IG or TR locus, in germline configuration, including at least one J-GENE and one C-GENE imgt:Segment_247_2|rdf:type|imgt:Segment imgt:Product_475ec8af-d4f7-3fe4-82b1-ba8b12a3c69d|imgt:hasStudyProduct|imgt:StudyProduct_870cb216-92e0-3b76-ae22-d76634800ed2 imgt:Clone_80|obo:RO_0002162|imgt:Musmus imgt:mAb_591|imgt:inn_number|10174 imgt:Product_1f926dbc-c738-3aa1-a4fc-1a5a0ec04af8|rdf:type|obo:NCIT_C51980 imgt:StudyProduct_8b2e4e04-64d3-32a1-9c3e-b0f965cb7b77|imgt:hasClinicalIndication|imgt:Melanoma imgt:Cancers_head_and_neck|imgt:isClinicalIndicationOf|imgt:StudyProduct_b87fb69e-090e-336d-a0fd-95a335fb5806 imgt:mAb_549|imgt:hasProduct|imgt:Product_b18c7489-8c67-32b7-93b0-4b6452620c97 imgt:StudyProduct_89118c8d-7608-3f85-ac54-b4741cfaeeb4|imgt:application_type|Therapeutic imgt:10224|imgt:isImgtStructureEntryOf|imgt:mAb_598 imgt:LRR3|rdfs:label|LRR3 imgt:StudyProduct_5a015869-203e-3633-b5b1-648059ab181c|imgt:isStudyProductOf|imgt:Product_a16baed9-ed2e-396b-98d0-5ddeb1eb104c imgt:StudyProduct_e18346b4-c502-3a24-9514-3f9ecb2d5d74|imgt:hasExpressionSystem|imgt:_Sp2/0_mouse_hybridoma_cells pubmed:8428365|dc:contributor|Ohsugi Y imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_1289578f-2bc9-3bf7-9a21-741d6e16a068 imgt:11827|imgt:isImgtStructureEntryOf|imgt:mAb_1227 imgt:Clone_132|rdfs:label|Clone_132 imgt:mAb_890|rdf:type|imgt:INN imgt:StudyProduct_ef73ae15-7bea-36d6-947c-43594144d0a8|rdf:type|obo:NCIT_C174271 imgt:mAb_238|imgt:imgt_note| obinutuzumab INN sequence and characteristics (disulfide bridges, glycosylation site) are those amended in L109 (2013) and published in R69 (2013). Biogen (Cambridge MA USA) and IDEC Pharmaceuticals (San Diego USA CA) merged in 2003 creating Biogen Idec. Biogen Idec has changed its name to Biogen (23 March 2015). Genentech Inc. is a member of Roche Group since March 26, 2009. GAZYVARO® is marketed as GAZYVA® outside of the EU and Switzerland. _:B19669455770995ecfb982801baea60de|imgt:isDecisionOf|imgt:StudyProduct_772021ea-8f08-37d4-a45a-9616e5a489d0 _:Bf861a4ab8dddc6a38ff1cdb522686aba|dc:date|2005-08-12 imgt:StudyProduct_47fe8ede-ae52-3e23-a933-4892db166791|imgt:hasClinicalIndication|imgt:Solid_tumors imgt:mAb_1224|imgt:inn_name|ensomafusp alfa imgt:StudyProduct_9ca532b7-4f84-3ca1-b57f-fff0036e4dd4|imgt:hasClinicalIndication|imgt:Cancers_colon imgt:Product_62e555bc-de18-34ed-b8f6-f3695acdd1ce|imgt:commun_name|unconjugated : AGS-22C3 or AGSM6 imgt:Clone_1249|obo:RO_0002162|imgt:Homsap imgt:mAb_632|rdf:type|imgt:INN imgt:StudyProduct_04a588ca-f4e9-3453-8e00-e517064379bc|imgt:isStudyProductOf|imgt:Product_e606d79d-bde1-3cc6-a544-20c1bf6683c4 _:B2e2418692ab81ff29ba814860f51fe93|imgt:isDecisionOf|imgt:StudyProduct_762ab1c3-8dde-3fee-9496-5629aeb9084a imgt:IFNAR1|imgt:isTargetOf|imgt:PROTEIN_1DOMAIN-PEG_737 imgt:Construct_498|imgt:hasImgtLabel|imgt:(scFv-heavy-kappa)-(scFv-heavy-lambda) imgt:11582|imgt:isImgtStructureEntryOf|imgt:mAb_1126 imgt:Product_8232fb63-0976-3003-9d0b-804e47a16825|imgt:hasStudyProduct|imgt:StudyProduct_6238d66f-2021-387b-b1dd-92265e7f354c imgt:Segment_636_1|imgt:hasImgtLabel|imgt:IFNL1 imgt:StudyProduct_4c9fd200-e7af-3f10-9c46-515efc0feb2b|imgt:hasClinicalIndication|imgt:Chronic_granulomatous_disease_(CGD) imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_cb165dea-b32d-3a5d-9161-130862d4c9e9 imgt:Clone_1157|imgt:clone_name|3F3 _:B73b0d0c9e6c40d6a741d3d0e415c3b8b|imgt:isDecisionOf|imgt:StudyProduct_8362701e-b95a-325e-8288-da965886a6f2 imgt:Segment_399_2|rdf:type|imgt:Segment imgt:StudyProduct_daf44e44-c01d-3a29-b352-4b015d4fc247|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:IgG1-kappa_379|imgt:hasMolecularComponent|imgt:IG imgt:mAb_548|imgt:inn_recommended_list|82 (2019) imgt:Construct_723|imgt:hasImgtLabel|imgt:IgG2-kappa imgt:Cancers_squamous|imgt:isClinicalIndicationOf|imgt:StudyProduct_df66b8bb-9491-3583-a2b2-3342c5f2393a imgt:mAb_668|imgt:inn_recommended_list|77 (2017) imgt:StudyProduct_cf928976-b0b8-39a0-92fc-e8fa9339991f|imgt:isStudyProductOf|imgt:Product_b9a7e713-902d-3fb3-afff-5da968f3c336 imgt:StudyProduct_edc037eb-991b-38b0-a754-be3ba8b8d178|imgt:hasClinicalIndication|imgt:Atopic_dermatitis_(AD) imgt:Construct_1043|rdf:type|imgt:Construct imgt:mAb_766|imgt:hasImgtStructureEntry|imgt:10646 obo:RO_0001019|rdfs:domain|faldo:Region imgt:mAb_228|imgt:hasImgtStructureEntry|imgt:10590 pubmed:8309946|dc:title|Humanization of a mouse anti-human IgE antibody: a potential therapeutic for IgE-mediated allergies. imgt:Segment_637_1|imgt:hasImgtLabel|imgt:IFNB1 imgt:mAb_96|imgt:inn_name|tocilizumab _:B746ac5bd753c0eedf43618f31eaf4fe9|imgt:isDecidedBy|imgt:FDA imgt:mAb_171|imgt:inn_proposed_list|102 (2009) imgt:Product_92683334-b9aa-397f-afad-ef30225a0323|imgt:commun_name|SAR-650984 imgt:Segment_13_1|obo:BFO_0000050|imgt:Construct_13 imgt:ZAP70|rdfs:label|ZAP70 obo:NCIT_C152273|rdfs:subClassOf|obo:NCIT_C1909 imgt:StudyProduct_4aa7a948-2d16-30f7-83bb-a19c45424e20|rdfs:label|StudyProduct_4aa7a948-2d16-30f7-83bb-a19c45424e20 imgt:IgG1-kappa-S239C_2cys-drug_904|rdf:type|imgt:MAbReceptor imgt:POLYA_SITE|rdf:type|imgt:RegulationLabel imgt:mAb_1071|imgt:hasMabReceptor|imgt:IgG4-lambda_1071 imgt:StudyProduct_0d159da4-02de-3768-90bb-c071c26d5c1a|imgt:application_type|Therapeutic imgt:Valerion_Therapeutics_LLC|rdfs:label|Valerion Therapeutics, LLC. imgt:StudyProduct_30f1e3f7-8634-3b1c-b40a-0a2722a5b718|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_d6dac861-cda2-3e3e-b302-80ea5d678ce2|rdf:type|obo:NCIT_C174271 imgt:IGF1R|skos:definition|IGF1R (insulin-like growth factor 1 receptor, IGF1-R, IGF-1R, CD221) imgt:Product_ff7f8ab2-ffcc-3549-b91f-01ae4cd1fac6|imgt:hasStudyProduct|imgt:StudyProduct_ea0afbf7-0368-37d0-9d22-e22c3668a661 imgt:Product_e9e52bcc-24ec-39dc-8de4-b4ba591c6845|rdf:type|obo:NCIT_C51980 imgt:Segment_633_1|rdfs:label|Segment_633_1 _:Be8dc678ec633dcbf8390208eccb053a9|dc:date|2014-04-30 imgt:StudyProduct_1df780ca-8602-328d-9d48-e259fef5c601|imgt:application_type|Therapeutic imgt:Product_6bc1d7d7-3572-3445-908f-a32d9aa7218d|imgt:isProductOf|imgt:mAb_559 imgt:Product_d38d61b1-643a-33d9-9785-f4b0aad161ed|rdfs:label|Product_d38d61b1-643a-33d9-9785-f4b0aad161ed imgt:IG-Heavy-Gamma-2-a-IGHG2A|imgt:defines|imgt:Fc-Gamma-2-a imgt:Segment_837_1|obo:BFO_0000050|imgt:Construct_837 imgt:Construct_446|obo:BFO_0000051|imgt:Segment_446_2 imgt:7828|rdfs:label|7828 imgt:Ridgeback_Biotherapeutics_LP|rdfs:comment|Coconut Grove , USA imgt:V-D-J-EXON|skos:definition|gDNA of an IG or TR in rearranged configuration, encompassing L-PART2, V-REGION, any D-REGION and any N-REGION, and J-REGION imgt:mAb_1064|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=1064 imgt:Lambda-Lambda|imgt:defines|imgt:Lambda-Lambda imgt:StudyProduct_abd6f0a5-7c5e-36fb-8b5c-0c9d2b6fbc0f|imgt:application_type|Therapeutic imgt:StudyProduct_a97a8d93-fa7e-3f39-ba19-1929fe3fab4c|imgt:hasClinicalIndication|imgt:Cancers_breast imgt:mAb_1071|imgt:hasImgtStructureEntry|imgt:11413 imgt:StudyProduct_3e303329-b47c-3318-9f05-a0e5b97359ed|imgt:isStudyProductOf|imgt:Product_804344aa-9846-368c-b3c2-764390d1bcc8 imgt:StudyProduct_fbc64e78-8c98-3434-b768-619855e75617|imgt:hasClinicalPhase|imgt:Phase_II imgt:mAb_1263|imgt:hasProduct|imgt:Product_34d390d4-4caa-3b24-b9bd-975fca71bdeb imgt:StudyProduct_91e80317-5746-38cb-821c-77be6c8c26c4|imgt:development_technology| POTELLIGENT® technology (afucosylation) imgt:mAb_1154|imgt:hasImgtStructureEntry|imgt:11636 imgt:Segment_834_1|rdf:type|imgt:Segment imgt:mAb_912|rdfs:label|mAb_912 imgt:truxima®|rdfs:comment| TRUXIMA® (rituximab CT-P10 rituximab-abbs) developed by Celltrion Inc. (Incheon Korea) approved in Korea (MFDS) on November 18 2016 for the treatment of rheumatoid arthritis (RA) chronic lymphocytic leukemia (CLL) and non-Hodgkin's lymphoma (NHL) approved by FDA on November 28 2018. Same clinical indications as MABTHERA® and RITUXAN®. imgt:StudyProduct_c18dfb91-f043-3ef9-9383-04d13a25ce28|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_24927660-46be-3320-af9b-3889951ff778|imgt:application_type|Therapeutic imgt:mAb_221|rdfs:label|mAb_221 imgt:StudyProduct_a99896ab-29c5-3fae-b076-1cf206ff08e6|rdf:type|obo:NCIT_C174271 imgt:IgG1-lambda-4cys-drug_665|rdf:type|imgt:MAbReceptor imgt:StudyProduct_ed873384-096e-3b31-a3a1-bae5c2714dde|imgt:isStudyProductOf|imgt:Product_27c6ab4e-8ce9-3ad2-92b3-945ee20d9e46 imgt:10316|imgt:isImgtStructureEntryOf|imgt:mAb_667 imgt:Segment_13_1|imgt:hasImgtLabel|imgt:IgG1-nd imgt:Product_23294cb2-f184-3e8c-86a4-69dff1f85cd9|imgt:isProductOf|imgt:mAb_1002 imgt:Product_483963c5-2edc-3412-9648-699e6b83a759|imgt:commun_name|MLN0002 imgt:ADM|obo:RO_0002162|imgt:Homsap imgt:StudyProduct_b9617fc0-a404-3cff-ac56-94d20bcda253|imgt:development_technology| BiTE® (Bispecific T cell Engager) technology imgt:Clone_1182|imgt:clone_name|IBI322-16-272-335 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imgt:Crohn's_disease_(CD)|imgt:isClinicalIndicationOf|imgt:StudyProduct_c47859a9-7323-3b02-9b97-441848f91191 imgt:StudyProduct_a4579212-c26a-3666-8b80-15da493b5d2b|rdf:type|obo:NCIT_C174271 imgt:IgG1-kappa-2cys-drug_815|http://semanticscience.org/resource/SIO_000291|imgt:LRRC15 imgt:MRC_Technology|imgt:produces|imgt:Product_2a2104d9-3a94-3396-af44-33905f4d1f8b imgt:StudyProduct_19d23e6a-0f31-3650-a817-d2389d919f74|imgt:development_technology| Dyax human antibody phage display library imgt:Product_d7c83c7a-94a0-330e-98d7-6d98bcc47c31|imgt:isProducedBy|imgt:Genmab_A/S imgt:Construct_965|rdfs:label|Construct_965 imgt:Clone_866|imgt:clone_name|PR-804-P05-20-P09-05 imgt:StudyProduct_9ed90791-6eef-326c-96b5-5f27dcea7e16|imgt:isStudyProductOf|imgt:Product_01f3c901-db8e-305c-8b01-2789aa0434c1 imgt:IgG4-kappa_595|rdfs:label|IgG4-kappa_595 imgt:zessly|rdfs:label|ZESSLY imgt:PROTEIN_1DOMAIN-PEG_634|http://semanticscience.org/resource/SIO_000291|imgt:KDR imgt:LHCGR|rdf:type|obo:NCIT_C25702 imgt:IgG1-kappa-6cys-drug_558|rdfs:comment|IgG1 - kappa - 6cys - drug imgt:IgG1-kappa_1150|obo:RO_0002162|imgt:Chi imgt:StudyProduct_d8190ccc-b57c-3021-9c9b-2142ef7f434e|imgt:hasClinicalIndication|imgt:Cancers imgt:StudyProduct_18bab775-f1d4-3bf1-93e0-a16f02bcd6c3|imgt:development_technology| Dual-Affinity Re-targenting (DART®) imgt:Gram-negative_sepsis|rdf:type|obo:NCIT_C185637 imgt:IgG1-kappa_766|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png obo:NCIT_C120554|rdf:type|owl:Class imgt:Clone_188|obo:RO_0002162|imgt:Homsap imgt:toxin|obo:RO_0002162|imgt:Borper imgt:StudyProduct_b97ea00c-a193-3e97-b1e7-738ccbd8aa85|rdf:type|obo:NCIT_C174271 imgt:Product_4f24624b-491f-33db-a319-e376f0ccc76f|rdfs:label|Product_4f24624b-491f-33db-a319-e376f0ccc76f imgt:Product_4c11ab27-05af-3a09-8d86-91e6154e14c1|imgt:commun_name|PRX002 imgt:Product_efb61065-7b20-3c3c-a956-d520973c84fe|imgt:commun_name|IMMU-4 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imgt:G1-kappa_scFv-h-CH2-CH3_1085|obo:RO_0002162|imgt:Hum _:B58b07bc4f64201d065d0bedce845fa5d|rdf:type|obo:NCIT_C53285 imgt:LTBR|skos:definition|Tumor necrosis factor receptor superfamily member 3 imgt:mAb_303|imgt:inn_recommended_list|44 (2000) _:B74b4700226a08554724b6e8bfc64869a|dc:date|2018-01-25 imgt:Product_bcb21f4c-72e4-3022-a04c-c911e4e8a2d0|imgt:commun_name|AGEN2034 imgt:StudyProduct_c905f749-92b7-35ce-8e77-1bb48e3bca6a|imgt:development_technology| Chimeric antigen receptor (CAR) T cell engineering imgt:Type_1_diabetes|rdf:type|obo:NCIT_C185637 imgt:BioNTech_SE|rdfs:comment|Mainz , Germany imgt:IgG1-lambda_1290|imgt:isMabReceptorOf|imgt:mAb_1290 obo:NCIT_C81166|rdf:type|owl:Class imgt:Product_165975b7-c4e2-3663-8b7e-03bb4d0ac418|imgt:hasStudyProduct|imgt:StudyProduct_1cb7d82f-0cd2-3305-9ca9-0bb9cf334893 imgt:KAN_Research_Institute_Inc|rdf:type|obo:NCIT_C54131 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imgt:MAbReceptor_114|imgt:hasMolecularComponent|imgt:IG imgt:IgG1-lambda_535|http://semanticscience.org/resource/SIO_000291|imgt:C5 imgt:IgG2-lambda_924|rdf:type|imgt:MAbReceptor imgt:MAbReceptor_1302|imgt:hasMolecularComponent|imgt:IG imgt:Product_87b4f91f-0f72-3325-99d8-da600f41c074|imgt:isProducedBy|imgt:Teva_Pharmaceutical_Industries_Ltd_(Cephalon) imgt:Construct_773|rdfs:label|Construct_773 _:Bbcdffdd6ce2f37d5309d9b24cb4ab037|imgt:isDecisionOf|imgt:StudyProduct_f9aa0ea1-c550-3cee-b95e-13dd8665a63a imgt:ANK-REPEAT|rdfs:label|ANK-REPEAT imgt:StudyProduct_e543e8e8-b123-3318-b436-d583a18ef879|imgt:application_type|Therapeutic imgt:mAb_503|imgt:inn_recommended_list|73 (2015) imgt:mAb_1043|rdf:type|imgt:INN imgt:StudyProduct_4e03a35f-639e-3c28-925a-2505a32230fa|rdf:type|obo:NCIT_C174271 imgt:Symphogen|imgt:produces|imgt:Product_80543f95-22b7-3761-a574-ef4df0802d70 imgt:IgG4-kappa_562|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG4-kappa.png imgt:scFv-heavy-kappa|imgt:construction_detail|scFv - heavy - kappa imgt:StudyProduct_b4e36d43-0876-3ff3-b45b-ec8429167295|imgt:application_type|Therapeutic imgt:CD3E|imgt:isTargetOf|imgt:VH-VL-VH%27-VL%27-CH2-CH3_1054 imgt:Product_916014f3-4780-3901-8e7b-eba7e0eeb0d5|rdf:type|obo:NCIT_C51980 imgt:IgG1-kappa_1076|imgt:isMabReceptorOf|imgt:mAb_1076 imgt:IgG1-kappa_554|rdf:type|imgt:MAbReceptor imgt:Bullous_pemphigoid|imgt:isClinicalIndicationOf|imgt:StudyProduct_469a2965-c713-3c5d-9a91-b1a0403bb593 obo:NCIT_C100101|rdfs:subClassOf|obo:NCIT_C1909 imgt:StudyProduct_5d73388e-1ce1-3b49-baa5-c24c65fbfd2d|rdfs:label|StudyProduct_5d73388e-1ce1-3b49-baa5-c24c65fbfd2d obo:NCIT_C175774|rdf:type|owl:Class pubmed:8931129|dc:title|A comparison of two murine monoclonal antibodies humanized by CDR-grafting and variable domain resurfacing. imgt:StudyProduct_c1117566-1853-3680-b415-167f13a10149|imgt:hasDecision|_:B7ce5a20d1ce487a7f39573322299139b 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imgt:12145|imgt:isImgtStructureEntryOf|imgt:mAb_1238 imgt:mAb_655|imgt:hasImgtStructureEntry|imgt:10382 imgt:Product_60e9fa18-d4b5-3b41-999a-e61a0ca37372|imgt:commun_name|anti-CD6-blocked ricin imgt:HOR-CTP_697|imgt:hasConstruct|imgt:Construct_697 imgt:Product_eabf76ed-a75b-38a7-beee-34c4b6f691bb|imgt:commun_name|oregovamab imgt:StudyProduct_76beb6a6-708c-38dd-9e66-0e207c521204|imgt:application_type|Therapeutic imgt:FPIA_%5BPROTEIN%5D2-FC_487|imgt:hasMolecularComponent|imgt:FPIA imgt:Biotest_AG|imgt:produces|imgt:Product_69aca6bd-b362-373e-98be-9f1735773595 imgt:IgG4-kappa_564|rdf:type|imgt:MAbReceptor imgt:Construct_787|imgt:hasImgtLabel|imgt:IgG-nd pubmed:3393390|rdfs:label|PMID_3393390 imgt:mAb_407|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=407 imgt:StudyProduct_48b01d58-4c5f-3786-a0ab-fcd7e0038c42|imgt:isStudyProductOf|imgt:Product_ed79f4b0-7ee9-336f-9b80-2a7c225d9ac4 imgt:IgG1-kappa_336|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png obo:NCIT_C146860|rdf:type|owl:Class imgt:StudyProduct_1b5cf8e3-aa2f-38ba-b7e3-e35fff725897|rdfs:label|StudyProduct_1b5cf8e3-aa2f-38ba-b7e3-e35fff725897 imgt:J-PHE|skos:definition|codon (3 nucleotides) for conserved phenylalanine at position 118 in G-STRAND of IG or TR V-DOMAIN (FR4-IMGT), in J-REGION of IG light chain or TR imgt:Construct_173|imgt:isConstructOf|imgt:scFv-heavy-kappa_173 imgt:StudyProduct_5a0cba82-db5d-38b2-aa35-2dd98c602d95|imgt:hasDecision|_:Bc5cfbf02cf6038f0b95bcb2e41df131e imgt:Segment_1112_1|obo:BFO_0000050|imgt:Construct_1112 imgt:mAb_792|imgt:hasMabReceptor|imgt:IgG1-lambda_792 imgt:StudyProduct_3e1c3e75-0f62-3155-a4de-382c650b2cc0|rdf:type|obo:NCIT_C174271 imgt:Construct_531|obo:BFO_0000051|imgt:Segment_531_1 imgt:mAb_62|imgt:hasProduct|imgt:Product_ffe79d3a-7340-3c62-883c-916bc4a8044e imgt:Construct_77|rdf:type|imgt:Construct imgt:IgG1-kappa_547|http://semanticscience.org/resource/SIO_000291|imgt:IGHE imgt:Clone_111|rdf:type|obo:NCIT_C37925 imgt:mAb_403|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=403 imgt:Cholangiocarcinoma|imgt:isClinicalIndicationOf|imgt:StudyProduct_c286e60e-41e0-36d5-b2cb-d414b008e43d imgt:Product_5fdc7efb-0010-311e-a532-3ec954b08b78|imgt:isProductOf|imgt:mAb_233 imgt:IG-MU_IOTA-3|skos:definition|IG receptor comprising two H-MU and two L-IOTA-3 chains imgt:Construct_1289|imgt:isConstructOf|imgt:IgG1-kappa-4cys-drug5_1289 imgt:IgG1-kappa_231|http://semanticscience.org/resource/SIO_000291|imgt:IL13 imgt:StudyProduct_db78e87f-1d08-345d-b723-fd170090c47c|rdf:type|obo:NCIT_C174271 imgt:Construct_613|obo:BFO_0000051|imgt:Segment_613_1 imgt:mAb_668|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=668 imgt:9533|rdfs:label|9533 imgt:9374|imgt:isImgtStructureEntryOf|imgt:mAb_366 imgt:Construct_1051|rdfs:label|Construct_1051 imgt:IgG1-kappa_98|imgt:radiolabelled_with| Indium-111, In-111 imgt:Staphylococcus_epidermidis_lipoteichoic_acid|rdf:type|obo:NCIT_C25702 imgt:StudyProduct_afef77f5-1ece-3756-9722-4edd208c7552|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:IgG1-lambda_956|imgt:isMabReceptorOf|imgt:mAb_956 imgt:StudyProduct_ff3ed28b-5382-3602-9a61-d06b879bf722|rdfs:label|StudyProduct_ff3ed28b-5382-3602-9a61-d06b879bf722 imgt:Product_fcbef86b-e625-3f8d-964f-93d0c8c3c7ef|imgt:isProductOf|imgt:mAb_509 imgt:StudyProduct_1d99192d-4b8f-35ef-bd0b-fa72bd86cd18|imgt:hasClinicalPhase|imgt:Phase_I imgt:StudyProduct_419a4556-e132-397a-82cb-9be68da5963f|imgt:hasClinicalIndication|imgt:Graft-versus-host_disease_(GvHD) _:B6a470e01747e73366e4aea29926b1c86|rdf:type|obo:NCIT_C53285 imgt:9713|imgt:isImgtStructureEntryOf|imgt:mAb_457 imgt:Construct_412|rdf:type|imgt:Construct imgt:Solid_tumors|imgt:isClinicalIndicationOf|imgt:StudyProduct_1884c1fa-e53a-3bd2-b507-eae4c4c1906e imgt:9321|rdfs:label|9321 imgt:IgG1-kappa_349|rdf:type|imgt:MAbReceptor imgt:Segment_999_1|imgt:hasImgtLabel|imgt:IgG4-kappa imgt:Construct_793|obo:BFO_0000051|imgt:Segment_793_1 imgt:Construct_880|obo:BFO_0000051|imgt:Segment_880_1 imgt:StudyProduct_eb7704fc-d825-3975-9e65-ca24023cad33|imgt:isStudyProductOf|imgt:Product_f0c3d7ec-73fc-3e13-804c-c87d05009d94 imgt:mAb_671|imgt:hasProduct|imgt:Product_dd5b0ea7-dfc0-3434-88fe-69d7271939ab imgt:IgG4-nd_3|imgt:hasMolecularComponent|imgt:IG imgt:Sanofi|imgt:produces|imgt:Product_4bf3114f-4cbf-347a-af9a-2e7f19e6991f imgt:Clone_314|imgt:clone_name|H65 imgt:IL13|imgt:isTargetOf|imgt:Fab-G1-kappa_804 imgt:Immunomedics_Inc|imgt:produces|imgt:Product_1d32d5b1-99c8-31ab-9a21-acfa4c132ab7 imgt:StudyProduct_1bb64584-3372-35f4-979c-739fd455f8fe|rdfs:label|StudyProduct_1bb64584-3372-35f4-979c-739fd455f8fe imgt:StudyProduct_47fe8ede-ae52-3e23-a933-4892db166791|rdf:type|obo:NCIT_C174271 imgt:mAb_1260|imgt:hasImgtStructureEntry|imgt:12022 imgt:StudyProduct_cb666bf7-76ef-38f3-ba4f-2d867501e03e|rdf:type|obo:NCIT_C174271 imgt:Clone_645|rdfs:label|Clone_645 imgt:StudyProduct_0f7055d8-c758-3097-87c0-4548bbf4491a|rdf:type|obo:NCIT_C174271 imgt:IL7R|skos:definition|IL7R (interleukin 7 receptor, IL7RA, CD127) imgt:Product_77f8ba38-fded-39d3-93d9-1a942135fbd4|rdf:type|obo:NCIT_C51980 imgt:StudyProduct_cd2510d3-90f0-37ba-a6f9-504913366008|imgt:hasClinicalIndication|imgt:Ankylosing_spondylitis_(AS) _:Bb8f3a2e470a0fc74a161df00dcda8d18|imgt:isDecidedBy|imgt:FDA imgt:Product_a22e1e73-39c4-3d58-810c-61a5fe2f2b92|imgt:isProductOf|imgt:mAb_1260 imgt:mAb_1094|imgt:inn_recommended_list|85 (2021) imgt:Segment_375_1|imgt:hasImgtLabel|imgt:IgG4-kappa imgt:mAb_47|imgt:hasProduct|imgt:Product_161faa12-b0ac-3430-b158-48f495203162 imgt:11141|imgt:isImgtStructureEntryOf|imgt:mAb_960 imgt:Product_e0741335-4875-3e01-a996-dc560274708e|rdfs:label|Product_e0741335-4875-3e01-a996-dc560274708e imgt:StudyProduct_4a0a6e3a-0139-3c93-b656-67e46a290237|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:IgG4-kappa_977|rdfs:comment|IgG4 - kappa imgt:mAb_1007|imgt:hasImgtStructureEntry|imgt:11211 imgt:Clone_118|obo:RO_0002162|imgt:Musmus imgt:StudyProduct_95f8f51f-1152-388e-b759-713b64855faf|rdfs:label|StudyProduct_95f8f51f-1152-388e-b759-713b64855faf imgt:Homozygous_familial_hypercholesterolemia_(HoFH)|imgt:isClinicalIndicationOf|imgt:StudyProduct_d492924c-a2a3-326f-b523-5710d41d12a6 imgt:Product_ecfa8f3a-cd95-3ccc-a977-0bea43414c8a|imgt:isProducedBy|imgt:Neogenix_Oncology_Inc imgt:FV-GAMMA_DELTA|rdf:type|imgt:StructureLabels imgt:Construct_86|rdf:type|imgt:Construct imgt:StudyProduct_c0e7c06f-c62b-3fe8-a0ab-ff5b39e9b281|imgt:isStudyProductOf|imgt:Product_0142f6fe-7297-3e48-855f-ae8298ad4948 imgt:StudyProduct_83022c95-c34d-302b-ac2f-5a4982727495|imgt:hasDecision|_:B08d5f0c8287cbdf582daf2e5d69d9554 imgt:IgM-kappa_scFv-heavy-kappa_1257|obo:RO_0002162|imgt:Homsap imgt:StudyProduct_c69aaa98-95ca-3d2b-88c1-fa0e760053df|imgt:hasClinicalIndication|imgt:Type_2_diabetes_(T2_DM) imgt:Product_9f6816fa-bfdc-3378-adc1-d4dd379f2138|imgt:commun_name|TAK-079 _:Be9f52a87b98f99457a00ed45741ec109|imgt:isDecisionOf|imgt:StudyProduct_dfb01347-79d7-3f8d-b192-1e95a225d3c4 imgt:mAb_270|rdfs:label|mAb_270 imgt:Adult_eosinophilic_asthma|imgt:isClinicalIndicationOf|imgt:StudyProduct_07c2f5c9-d098-3e2a-aeda-aface4f5a09a imgt:Dyax_Corp|rdf:type|obo:NCIT_C54131 imgt:Segment_413_3|imgt:hasImgtLabel|imgt:IGHG1 imgt:PROTEIN_1DOMAIN-PEG_629|http://semanticscience.org/resource/SIO_000291|imgt:IFNAR1 imgt:Segment_867_1|obo:BFO_0000050|imgt:Construct_867 imgt:Product_c7e70c82-a2f1-32d7-9982-829cd1d4d4e7|imgt:isProductOf|imgt:mAb_568 imgt:Product_32b86460-a45e-3754-b094-c62785f30884|imgt:hasStudyProduct|imgt:StudyProduct_08b9cb90-6d16-3be4-9762-c96c5f4f1501 imgt:StudyProduct_3b92338f-1569-3227-9eea-a1f46a67f928|imgt:hasDecision|_:B2e5cd6a94d8e0eb99c3f88b4fa0e7266 imgt:Construct_806|obo:BFO_0000051|imgt:Segment_806_1 imgt:Product_08bd6972-3307-3ac1-9be9-270ca2564841|imgt:isProductOf|imgt:mAb_1186 imgt:VH-VH%27-H-Gamma1-VL-VL%27-C-kappa_517|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/VH-VH'-H-Gamma1-VL-VL'-C-kappa.png imgt:C5|skos:definition|C5 (complement 5) imgt:Product_12be981a-d52d-3197-b2a3-b970642e0c79|imgt:isProducedBy|imgt:Sinocelltech_Ltd _:Baf347226fbf0b9f9efb69ba637202e1c|dc:date|2022-03-18 imgt:Segment_397_1|imgt:segment_detail|98-127 (glucagon-like peptide 1, GLP1) 7-36 imgt:mAb_610|rdf:type|imgt:INN imgt:Clone_558|rdf:type|obo:NCIT_C37925 imgt:Construct_685|rdf:type|imgt:Construct imgt:Product_1359517a-169f-37c5-bcf3-e739b8e3653d|imgt:hasStudyProduct|imgt:StudyProduct_34126c3d-db6b-30d9-947b-8ddb35129177 _:Bb23dd2bc585b4e061dc43d835d8fc2f8|imgt:isDecisionOf|imgt:StudyProduct_d0ef6cb1-edf4-3df0-930b-7ea881c98a95 imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_6a3d73b1-d98e-3a7a-a499-079a203ad53f imgt:mAb_13|imgt:hasProduct|imgt:Product_c10a43ba-cfd6-3610-84b1-dabd23fd8ede imgt:StudyProduct_5654df68-9e63-3113-a117-b2c763657f36|rdfs:label|StudyProduct_5654df68-9e63-3113-a117-b2c763657f36 _:B4932bbb58f7ed34af26266c4417f5d3f|rdf:type|obo:NCIT_C53285 imgt:mAb_806|rdf:type|imgt:INN imgt:mAb_382|imgt:hasOriginClone|imgt:Clone_382 imgt:Construct_728|rdfs:label|Construct_728 imgt:StudyProduct_4b3ccea3-961f-3102-9e9c-20f015542dfe|rdfs:label|StudyProduct_4b3ccea3-961f-3102-9e9c-20f015542dfe imgt:Malignant_pleural_effusion|rdf:type|obo:NCIT_C185637 imgt:1L7I|imgt:isImgtStructureEntryOf|imgt:mAb_80 _:Bd703c4994349002ad6081908a495ccc5|rdf:type|obo:NCIT_C53285 imgt:9688|imgt:isImgtStructureEntryOf|imgt:mAb_452 imgt:Construct_945|rdfs:label|Construct_945 imgt:Construct_389|imgt:isConstructOf|imgt:IgG4-kappa-4lys-drug_389 imgt:Product_16d030ee-d4af-35e5-af65-2c8a5b6b131f|imgt:commun_name|EM-901 imgt:Centocor_Inc|imgt:produces|imgt:Product_c2a35708-7257-3084-8079-8ca3bcca6373 imgt:StudyProduct_a6f45061-c9c7-3e16-9147-26b49563e46b|imgt:hasClinicalIndication|imgt:Melanoma imgt:Cancers_breast|imgt:isClinicalIndicationOf|imgt:StudyProduct_d6603759-fe6a-3cb2-bdef-285ef9c6777e imgt:Construct_676|rdfs:label|Construct_676 imgt:Product_ed1e8186-4f31-37d5-85c3-9b5b8b1a524f|imgt:hasStudyProduct|imgt:StudyProduct_e32291ae-4c12-389d-9d34-49b8592b09c1 imgt:VZV_(envelope_glycoprotein_H)|rdf:type|obo:NCIT_C25702 imgt:VIRLabel|rdfs:subClassOf|imgt:StructureLabels imgt:mAb_476|imgt:imgt_note| Agensys, Inc. is an affiliate of Astellas Pharma Inc. The average AGS-22-CS molecule has a molar ratio of 3.8 drugs per antibody molecule imgt:StudyProduct_c15bccdd-bf01-38ee-b5a7-5a4e74d5fde2|imgt:isStudyProductOf|imgt:Product_c2a35708-7257-3084-8079-8ca3bcca6373 imgt:Segment_264_2|rdf:type|imgt:Segment imgt:VH-V-LAMBDA|skos:definition|Chain or receptor comprising a VH and a L-LAMBDA domains imgt:Construct_982|rdfs:label|Construct_982 imgt:FUSION-SCFV-KAPPA-HEAVY-ETA|rdf:type|imgt:ChainLabels imgt:Segment_268_1|imgt:hasImgtLabel|imgt:IgG1-nd imgt:F(ab%27)2-G3-kappa_128|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/F(ab')2-G3-kappa.png imgt:IgG1-kappa-%5BPROTEIN%5D2_1223|http://semanticscience.org/resource/SIO_000291|imgt:IL2RG imgt:Product_9714b306-6ce1-3c30-b822-479b49ca52de|rdfs:label|Product_9714b306-6ce1-3c30-b822-479b49ca52de imgt:IgG1-kappa_1094|obo:RO_0002162|imgt:Chi imgt:StudyProduct_e6e1484c-6b19-39e1-8c86-fdd4a1500997|rdfs:label|StudyProduct_e6e1484c-6b19-39e1-8c86-fdd4a1500997 pubmed:21091310|dc:contributor|Fox EJ imgt:StudyProduct_0a7ee814-2505-3fad-b45d-eb973c69a29d|rdf:type|obo:NCIT_C174271 imgt:IgG1-kappa_853|rdf:type|imgt:MAbReceptor imgt:StudyProduct_a67a0c59-7b7f-38d1-aa09-7b70854fe345|rdf:type|obo:NCIT_C174271 imgt:J-SPACER|rdfs:label|J-SPACER imgt:IgG1-kappa_168|imgt:hasMolecularComponent|imgt:IG imgt:Product_38366130-a996-3336-8943-ab4efcfb1fbc|imgt:commun_name|unconjugated : AGS-22C3 or AGSM6 imgt:F7_(Pr213-466)|skos:definition|Coagulation factor VII imgt:Construct_856|rdfs:label|Construct_856 imgt:11056|imgt:isImgtStructureEntryOf|imgt:mAb_948 imgt:CD274|imgt:isTargetOf|imgt:IgG1-lambda-kappa(2)_1119 imgt:F(ab%27)2-G3-kappa_128|http://semanticscience.org/resource/SIO_000291|imgt:TNF imgt:mAb_574|imgt:inn_proposed_list|113 (2015) imgt:StudyProduct_608cec66-6b49-3ffc-965e-9d278f033de8|imgt:application_type|Therapeutic imgt:ArmaGen_Inc|rdfs:comment|Calabas , USA _:Bc14ac54c22c74bb29088253218119f32|dc:date|2009-04-24 imgt:StudyProduct_1833d0a8-c298-3a28-a897-c4ea51020252|rdfs:label|StudyProduct_1833d0a8-c298-3a28-a897-c4ea51020252 imgt:GCG_(glucagon)_146-178_(glucagon-like_peptide_2_GLP2)_2-glycine-peptide_2_analogue|imgt:construction_detail|GCG (glucagon) 146-178 (glucagon-like peptide 2, GLP2) 2-glycine-peptide 2 analogue imgt:StudyProduct_9cad8c06-7815-3bb8-9d5a-d03c23192156|imgt:hasClinicalIndication|imgt:Neuroblastoma_pediatric imgt:IgG1-kappa_274|rdfs:label|IgG1-kappa_274 imgt:Segment_214_1|obo:BFO_0000050|imgt:Construct_214 imgt:IgG1-kappa_1194|imgt:isMabReceptorOf|imgt:mAb_1194 imgt:StudyProduct_6e8862e1-6025-3b68-abe0-2478f8808aaa|imgt:hasDecision|_:B3bfb64b9fe3d8916dbf3d53c8b0a7adf imgt:Product_cef966d9-7220-3c3b-8d4c-3695c4e55488|imgt:commun_name|ESBA-1622 imgt:Construct_269|obo:BFO_0000051|imgt:Segment_269_1 imgt:mAb_1258|rdfs:label|mAb_1258 imgt:Product_58a491b5-79db-3fa2-b693-4ba518a8dcac|imgt:commun_name|AGS15C –SGD-1006 imgt:StudyProduct_570b0f62-6343-325d-9344-8d8294daefd4|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:mAb_75|rdf:type|imgt:INN imgt:Segment_446_1|rdfs:label|Segment_446_1 imgt:Segment_1158_3|imgt:hasImgtLabel|imgt:FGFR1 imgt:Product_f84d9b3b-a562-3515-9186-fc2d57976aa5|imgt:hasStudyProduct|imgt:StudyProduct_b491f4a1-8ff3-3630-af35-11b68c0fb731 imgt:FASLG|rdf:type|obo:NCIT_C25702 imgt:StudyProduct_1ac3ad92-0b63-3d1e-894d-38863d15c6a5|rdf:type|obo:NCIT_C174271 imgt:Product_438169eb-1ed6-3400-8ca1-cc7d334d5640|imgt:commun_name|ASG-22ME imgt:StudyProduct_961a8cbb-97f6-330d-a900-59d58ea33047|imgt:hasClinicalIndication|imgt:Osteomalacia_oncogenic imgt:StudyProduct_6d61fdae-1304-33c2-8720-c865ada225cd|imgt:isStudyProductOf|imgt:Product_e92a1f6b-b0a8-3d24-915b-82fcb6694c39 imgt:Product_90f4823e-5cb9-333f-bd91-f83046626483|imgt:hasStudyProduct|imgt:StudyProduct_34a1caac-6f2c-3e1e-9946-120ac114ef28 imgt:Construct_603|obo:BFO_0000051|imgt:Segment_603_1 imgt:%5BV-kappa%5D2-Fc_429|obo:RO_0002162|imgt:Homsap _:B92f409afcceea6676eaeafda63a76fb4|dc:date|2014-05-29 imgt:IgG1-kappa_572|rdf:type|imgt:MAbReceptor imgt:L-V-D-J-C-chain|protege:protege#subclassesDisjoint|true imgt:Construct_508|obo:BFO_0000051|imgt:Segment_508_1 imgt:StudyProduct_b11269fe-e332-3368-a43f-122b11dfc8db|imgt:application_type|Therapeutic imgt:StudyProduct_415efdcc-8613-3723-a864-a37bb37c4a53|imgt:hasExpressionSystem|imgt:_XpressCF+™ imgt:StudyProduct_a49e9411-d64f-353e-8cfd-d09ad10a15b3|rdfs:label|StudyProduct_a49e9411-d64f-353e-8cfd-d09ad10a15b3 imgt:Product_2624320e-1e97-3af4-89b8-c8b313ff97f4|rdf:type|obo:NCIT_C51980 imgt:mAb_843|imgt:inn_name|efmitermant alfa imgt:VH-CH1-SCFV-HEAVY-KAPPA|rdfs:label|VH-CH1-SCFV-HEAVY-KAPPA imgt:IgG1-kappa_1264|imgt:hasConstruct|imgt:Construct_1264 imgt:StudyProduct_41e90f6e-c090-366c-96f0-1c5ba688abe4|rdfs:label|StudyProduct_41e90f6e-c090-366c-96f0-1c5ba688abe4 imgt:StudyProduct_d61cdbc7-d49b-3c3c-8db0-e0f053e8957e|rdfs:label|StudyProduct_d61cdbc7-d49b-3c3c-8db0-e0f053e8957e imgt:IgG1-kappa_417|imgt:hasMolecularComponent|imgt:IG imgt:StudyProduct_82dde1e2-eead-3694-b95a-d3c6a1467300|rdfs:label|StudyProduct_82dde1e2-eead-3694-b95a-d3c6a1467300 imgt:Construct_1251|rdf:type|imgt:Construct _:Bbe09eaeda9c719d931e6d4f6b4b67ee5|imgt:hasDesignation|imgt:Orphan_drug imgt:IgG4-kappa_556|rdfs:label|IgG4-kappa_556 imgt:StudyProduct_0bf9653b-86cf-3e52-9bef-23c6b999731e|imgt:isStudyProductOf|imgt:Product_a1e50f83-c20d-35e3-9283-988f5a4850ad imgt:ANKYRIN|rdf:type|imgt:ChainLabels imgt:scFv-scFv-scFc_lambda_1200|http://semanticscience.org/resource/SIO_000291|imgt:MUC17 imgt:3'V-REGION|skos:definition|region from 2nd-CYS to the 3' end of the V-REGION (for germline or rearranged), with same 3' end delimitation (nt) as V-REGION, in gDNA or in cDNA imgt:mAb_1110|rdfs:label|mAb_1110 imgt:Product_711d76e7-b1b0-3c1e-b6b1-19c1df3bcad1|imgt:commun_name|RG-7597 imgt:mAb_381|imgt:inn_name|narnatumab imgt:mAb_398|rdf:type|imgt:INN imgt:Product_b2047389-8f1a-3406-9333-efe3ec11daac|imgt:hasStudyProduct|imgt:StudyProduct_5d73388e-1ce1-3b49-baa5-c24c65fbfd2d imgt:IgG1-kappa_255|rdf:type|imgt:MAbReceptor imgt:IgG1-kappa_913|rdfs:label|IgG1-kappa_913 imgt:StudyProduct_28790f9e-30be-3e9c-b827-69ba060ccb1e|imgt:hasDecision|_:B0f5064bb9e544923cfb2fc282a492665 imgt:StudyProduct_07dfb1be-7cba-3419-a233-465efef5c44d|imgt:isStudyProductOf|imgt:Product_02550586-7a1b-3018-bf60-0ad7c06c9f86 imgt:IgG1-lambda_1238|rdfs:label|IgG1-lambda_1238 imgt:Clone_42|rdfs:label|Clone_42 imgt:StudyProduct_ff1a9f4e-d90b-3b0f-aeee-532955fda8a4|rdf:type|obo:NCIT_C174271 imgt:Product_d7375334-d0db-32f3-81ba-3cfa540a5cf4|imgt:hasStudyProduct|imgt:StudyProduct_e0daf030-fc7e-3412-ac9a-5502e64e6f88 imgt:StudyProduct_9ac34664-9570-3c7d-90b6-3eb23cd0e79b|imgt:hasClinicalPhase|imgt:Phase_M imgt:Segment_970_1|imgt:hasImgtLabel|imgt:IgG4-kappa imgt:Construct_824|imgt:isConstructOf|imgt:FPIA_FC-%5BPROTEIN%5D2_824 imgt:Segment_678_1|imgt:has_rank|1 imgt:Glioblastoma|imgt:isClinicalIndicationOf|imgt:StudyProduct_25a6c8e9-1ad5-39ee-8db0-028214308a24 _:Bcd50bb786e7f6611279b1b309fe2613b|rdf:type|obo:NCIT_C53285 imgt:StudyProduct_17fffcc0-45dc-3607-ba3a-7a9c5ec0a221|rdf:type|obo:NCIT_C174271 imgt:Cancers_pancreatic|imgt:isClinicalIndicationOf|imgt:StudyProduct_731e0a81-9e68-35db-b84d-365665c4a62b imgt:Product_a05390bf-1495-3785-a5b6-edf17b39170e|imgt:isProducedBy|imgt:Roche_F_Hoffmann-La_Roche_Ltd imgt:Product_eee3061f-bf14-3e3d-9646-c7c2fe6d3166|imgt:isProducedBy|imgt:Medarex imgt:F(ab’)2-Gamma-2-b_Kappa|imgt:isDefinedBy|imgt:IG-Heavy-Gamma-2-b-IGHG2B imgt:Product_472580a9-a9b7-36d2-8b15-c38c1bd71e1f|imgt:isProducedBy|imgt:Millennium_Pharmaceuticals_Inc imgt:Product_e98a7b41-0f51-3064-ae4a-a9ee58d6b895|rdf:type|obo:NCIT_C51980 imgt:Osteoarthritis_(OA)|rdfs:label|Osteoarthritis_(OA) imgt:Globo_H|imgt:isTargetOf|imgt:MAbReceptor_1166 imgt:StudyProduct_91d1e008-c2d8-3b4c-8b31-e5faddcb4b37|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:StudyProduct_cac1079e-e48e-330a-a7b6-9da80544e492|imgt:isStudyProductOf|imgt:Product_c4b5a4f9-01ee-3823-90ef-f047993fe32e _:B3dee6172fadeb5a9535020bf1dde1ade|imgt:isDecisionOf|imgt:StudyProduct_90360979-47fa-3ad6-ab83-9143ad9b06be imgt:Product_892634ba-c82f-36f9-9106-1537e1c79b28|imgt:hasStudyProduct|imgt:StudyProduct_58fd01ed-11b1-3d24-b0db-8844bb814951 imgt:Product_4391f6b4-98b1-38e2-94d2-967326f820fe|imgt:hasStudyProduct|imgt:StudyProduct_f1853933-358a-3fe4-aaa5-ae1d1aad92b7 imgt:Segment_1176_1|rdfs:label|Segment_1176_1 imgt:Segment_613_3|imgt:hasImgtLabel|imgt:IGHG4 imgt:Product_dcf2f323-352b-3484-abe2-f1687814dc60|rdfs:label|Product_dcf2f323-352b-3484-abe2-f1687814dc60 imgt:half-G1-kappa_scFv-HEAVY-LAMBDA-h-CH2-CH3_920|rdf:type|imgt:MAbReceptor imgt:H-CH2-CH3|rdfs:label|H-CH2-CH3 imgt:IgG1-kappa_261|http://semanticscience.org/resource/SIO_000291|imgt:fibrin-binding_surface_epitope_clumping_factor_A imgt:mAb_946|rdfs:label|mAb_946 imgt:StudyProduct_fa63fa2f-f4fb-3169-9a7a-39ce5cdb63c7|imgt:hasClinicalIndication|imgt:Psoriasis imgt:StudyProduct_c9240909-e6ce-3134-b3c0-f9bc48f5d4f4|rdf:type|obo:NCIT_C174271 imgt:10737|rdfs:label|10737 imgt:StudyProduct_4ce0d1e9-2be8-3981-94d6-170ce87e91d5|rdf:type|obo:NCIT_C174271 imgt:Segment_394_2|rdf:type|imgt:Segment imgt:StudyProduct_1488a7ea-5fe0-3ac3-a8a3-82aeca5bfbac|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:StudyProduct_c8ae31b6-988f-31d9-b3f8-d4e8e0c245ce|rdfs:label|StudyProduct_c8ae31b6-988f-31d9-b3f8-d4e8e0c245ce imgt:StudyProduct_49c97a1d-0850-3fad-97df-ddda4fd3e497|imgt:isStudyProductOf|imgt:Product_6333261c-0d6e-371b-919b-12076c3a014c imgt:Product_f4c1df4f-2677-3e9d-9741-4a08b92eb031|imgt:isProductOf|imgt:mAb_241 imgt:12362|imgt:isImgtStructureEntryOf|imgt:mAb_1247 imgt:(VJ)-C-CLUSTER|rdfs:label|(VJ)-C-CLUSTER imgt:StudyProduct_95f2348f-0d7e-3304-99e9-a1649fc0abe7|imgt:hasDecision|_:B896840c02032358f107d9a350da23b4c imgt:Product_8a6a655e-c029-3db0-abba-ab5a2dc29089|imgt:commun_name|MDX-010 imgt:Construct_526|rdfs:label|Construct_526 imgt:D1-REGION|rdf:type|imgt:CoreLabel imgt:CH3-CH4|skos:definition|CH3 and CH4 C-DOMAINs from an IG-HEAVY (H) chain imgt:Product_55b8a3e2-4377-316b-b207-25ad9507669a|imgt:commun_name|PBP 1510 imgt:MS4A1|imgt:isTargetOf|imgt:IgG4-nd_748 imgt:IG-Heavy-Gamma-3-IGHG3|imgt:defines|imgt:IgG3_Kappa imgt:CD28|skos:definition|CD28 (TP44, T cell specific surface glycoprotein CD28) imgt:StudyProduct_9578ebf7-143d-3548-9867-706dd07f2f9a|rdf:type|obo:NCIT_C174271 imgt:Segment_1073_1|obo:BFO_0000050|imgt:Construct_1073 imgt:Clone_1077|rdfs:label|Clone_1077 _:Be5f92519e80e9ee429029636d1aed2ca|imgt:isDecisionOf|imgt:StudyProduct_bc606674-85bc-39c9-b047-4a11a0d34321 obo:ERO_0000405|owl:inverseOf|imgt:isAccessionNumberOf imgt:Fv-Gamma_Delta|rdf:type|imgt:ReceptorType imgt:StudyProduct_830193a8-dcb3-30cc-9d67-b921881c4d6d|imgt:hasClinicalIndication|imgt:Solid_tumors imgt:mAb_647|imgt:inn_name|burosumab imgt:Product_d7fdef9d-ffc1-3cfa-a0c4-55b5452505c5|rdfs:label|Product_d7fdef9d-ffc1-3cfa-a0c4-55b5452505c5 imgt:EX4|rdfs:label|EX4 imgt:Asthma|imgt:isClinicalIndicationOf|imgt:StudyProduct_a0cee844-95a7-3621-85d5-dddc3c33fda3 imgt:IgG1-kappa_1104|rdfs:comment|IgG1 - kappa imgt:Construct_259|imgt:isConstructOf|imgt:IgG4-kappa_259 imgt:Construct_638|imgt:isConstructOf|imgt:PROTEIN_1DOMAIN_638 imgt:mAb_1092|rdfs:label|mAb_1092 imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_f3cb0d51-0ece-38b1-a867-a2fde28d62a3 imgt:Laboratoire_Français_du_fractionnement_et_des_Biotechnologies_(LFB)|rdfs:label|Laboratoire Français du fractionnement et des Biotechnologies (LFB) imgt:hapten_NP-cap|imgt:isTargetOf|imgt:IgE-nd_54 imgt:high-risk_hematopoietic_stem_cell_transplant-associated_thrombotic_microangiopathy_(HSCT-TMA)|imgt:clinical_domain|Oncology imgt:StudyProduct_f39528a1-ec68-39ee-a847-69451657ce25|rdfs:label|StudyProduct_f39528a1-ec68-39ee-a847-69451657ce25 imgt:StudyProduct_c3bac2e0-465b-3fba-bcf3-be022b1e732e|rdfs:label|StudyProduct_c3bac2e0-465b-3fba-bcf3-be022b1e732e imgt:Autoimmune_diseases|imgt:isClinicalIndicationOf|imgt:StudyProduct_2b7f353a-d8aa-3509-b95e-9945de9a63ae imgt:StudyProduct_993b42c9-04b6-37fc-aee8-478969b79fa4|rdfs:label|StudyProduct_993b42c9-04b6-37fc-aee8-478969b79fa4 imgt:Killer_cell_lectine-like_receptor|dc:identifier|imgt_000293 imgt:IgG1-kappa_504|rdf:type|imgt:MAbReceptor imgt:StudyProduct_4bb50129-b3f6-36d9-b2a1-041dcec42164|imgt:application_type|Therapeutic imgt:mAb_400|imgt:inn_name|sarilumab imgt:StudyProduct_4b310d9f-8117-369c-83fa-2873787eda90|rdf:type|obo:NCIT_C174271 imgt:mAb_673|imgt:clinical_trials|13 studies found, 2 recruiting imgt:Construct_1246|obo:BFO_0000051|imgt:Segment_1246_1 imgt:Segment_450_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:StudyProduct_90ded528-5aeb-3f2f-ad4a-9fc2f1cbaa5c|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_91c8c4c2-c45b-3abc-b0d3-014bbfc1b9ab|rdf:type|obo:NCIT_C174271 imgt:Clone_1251|imgt:clone_name|L62M81 imgt:Innovent_Biologics|imgt:produces|imgt:Product_390fb47e-7119-3e38-9d5f-5f1c1b59df0d imgt:Facet_Biotech|rdf:type|obo:NCIT_C54131 imgt:Product_8ab7fc81-b8d6-308e-9064-5a153be43d1b|imgt:isProductOf|imgt:mAb_1098 imgt:Construct_190|imgt:hasImgtLabel|imgt:IgG1-nd imgt:LCN1|rdf:type|imgt:SegmentLabels imgt:9323|imgt:isImgtStructureEntryOf|imgt:mAb_168 imgt:MorphoSys|imgt:produces|imgt:Product_5af2b777-511f-3260-bde3-2f7f1819889f imgt:IgG1-lambda_348|imgt:hasMolecularComponent|imgt:IG imgt:StudyProduct_c5074f11-9520-3726-bb53-f999c28df5fc|imgt:application_type|Therapeutic imgt:Product_d0ab5070-db16-3ae6-b607-37ad63abcbcc|imgt:hasStudyProduct|imgt:StudyProduct_0d2cb8c0-e68b-3e47-9b1e-a501c7e245ab imgt:Segment_221_1|imgt:hasImgtLabel|imgt:F(ab)2-G1-nd imgt:mAb_814|imgt:hasMabReceptor|imgt:IgG1-kappa-4cys-drug_814 _:Bea823398c818e9170453fd4090d146a4|imgt:isDecidedBy|imgt:FDA imgt:IgG2-kappa-%5BPROTEIN%5D2_908|imgt:hasConstruct|imgt:Construct_908 imgt:Construct_857|rdf:type|imgt:Construct imgt:mAb_448|imgt:hasProduct|imgt:Product_9f3b70a8-1ab1-357c-82db-a284346f9860 imgt:Segment_502_1|imgt:has_rank|1 imgt:Segment_331_2|rdfs:label|Segment_331_2 imgt:Segment_1149_1|imgt:hasImgtLabel|imgt:IgG1-lambda2 imgt:IgG2-G4-kappa|rdfs:label|IgG2-G4 - kappa imgt:IgG1-kappa_87|rdf:type|imgt:MAbReceptor imgt:mAb_692|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=692 imgt:Hemophilia_B_(with_inhibitors)|imgt:clinical_domain|Hematology imgt:StudyProduct_c705bca7-5973-3e15-87f9-106e3fa87b06|rdfs:label|StudyProduct_c705bca7-5973-3e15-87f9-106e3fa87b06 imgt:Product_ecb3c0eb-db31-3f63-a0a2-a59c047defae|rdf:type|obo:NCIT_C51980 imgt:Product_2bfb276f-0cd4-3496-a28f-c9af723650c0|imgt:isProductOf|imgt:mAb_584 imgt:Construct_430|rdfs:label|Construct_430 imgt:GPC3|imgt:isTargetOf|imgt:IgG1-kappa_466 imgt:Product_f3abdd35-f591-3d8f-9db6-8a118a10c572|imgt:isProducedBy|imgt:University_of_California imgt:EX2C|rdf:type|imgt:C-RegionExonLabel imgt:PROTEIN_1DOMAIN-PEG_625|imgt:hasMolecularComponent|imgt:RPI imgt:StudyProduct_3c33cf64-59ff-3621-8d4f-95a3d85afee6|imgt:application_type|Therapeutic obo:NCIT_C41207|rdfs:label|Chain imgt:StudyProduct_f9ebad83-378a-39ab-9408-576c062cfcdf|imgt:application_type|Therapeutic imgt:StudyProduct_19956f23-5079-3cdc-a50c-e6fb4aebfc9f|imgt:hasClinicalPhase|imgt:Phase_II imgt:CTLA4|rdf:type|imgt:SegmentLabels imgt:StudyProduct_118ca9c4-e6f8-34e1-a003-b93f6f5b8d89|imgt:hasClinicalIndication|imgt:Musculoskeletal_diseases imgt:StudyProduct_cf211e0b-6a75-3b78-919e-27956a3554aa|rdfs:label|StudyProduct_cf211e0b-6a75-3b78-919e-27956a3554aa imgt:mAb_530|rdf:type|imgt:INN imgt:Melanoma_metastatic_or_unresectable|imgt:clinical_domain|Oncology imgt:IgM-nd_140|imgt:hasConstruct|imgt:Construct_140 imgt:mAb_580|imgt:hasProduct|imgt:Product_cf289a81-4759-3b71-b23f-2bf99ef59edf imgt:mAb_326|imgt:clinical_trials|164 studies found, 37 recruiting imgt:Product_73c8f272-2743-3eb0-8838-5a74f2a6d142|rdfs:label|Product_73c8f272-2743-3eb0-8838-5a74f2a6d142 imgt:StudyProduct_ec44632e-85a9-3925-a446-75a4f03602f3|imgt:hasClinicalPhase|imgt:Phase_I imgt:9310|rdf:type|obo:NCIT_C25402 imgt:StudyProduct_891fb42a-584d-39d0-adbc-58d869837ab6|imgt:hasClinicalIndication|imgt:Influenza_A_infection imgt:StudyProduct_ba5846bc-9689-3122-b3c1-045007a7f673|imgt:hasClinicalPhase|imgt:Phase_II imgt:SELE|rdf:type|obo:NCIT_C25702 imgt:Product_eabf76ed-a75b-38a7-beee-34c4b6f691bb|imgt:isProducedBy|imgt:AltaRex_Corp pubmed:10960454|dc:title|Preclinical evaluation of two human anti-hepatitis B virus (HBV) monoclonal antibodies in the HBV-trimera mouse model and in HBV chronic carrier chimpanzees. imgt:Product_bba8b2a4-0f05-3650-b850-894d24293147|imgt:hasStudyProduct|imgt:StudyProduct_48474ed3-d570-312e-a6fb-683e3913eea7 imgt:IgG4-kappa_564|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG4-kappa.png imgt:IgG2a-kappa/G2b-lambda|rdfs:label|IgG2a - kappa / G2b - lambda imgt:MPL|rdf:type|obo:NCIT_C25702 imgt:StudyProduct_19cc6408-f0aa-3834-ad48-f94c100cab33|imgt:hasClinicalIndication|imgt:Lymphoma_cutaneous_T_cell_(CTCL) imgt:hasMoleculeUnit|rdf:type|owl:ObjectProperty imgt:12050|imgt:isImgtStructureEntryOf|imgt:mAb_1251 imgt:Clone_356|imgt:clone_name|C2aB7 imgt:Chronic_granulomatous_disease_(CGD)|imgt:clinical_domain|Hematology imgt:StudyProduct_f4807e52-f39a-3b92-ad82-f3540c8f3fcc|imgt:hasClinicalPhase|imgt:Discontinued _:B6a63787b4e9d2b7c4f9b2732560a31a3|imgt:isDecidedBy|imgt:FDA imgt:Segment_830_1|imgt:has_rank|1 imgt:Product_92683334-b9aa-397f-afad-ef30225a0323|imgt:commun_name|hu38SB19 _:B8658f4b34f94117c1c7835c589ce931d|imgt:isDecidedBy|imgt:FDA imgt:F(AB%27)2-GAMMA-2B_LAMBDA|rdf:type|imgt:IGProteolyticFragmentLabel imgt:Lupus_nephritis|rdf:type|obo:NCIT_C185637 imgt:mAb_825|imgt:inn_recommended_list|80 (2018) imgt:Segment_1210_1|obo:BFO_0000050|imgt:Construct_1210 imgt:Chronic_lymphocytic_leukemia_(CLL)|rdfs:label|Chronic_lymphocytic_leukemia_(CLL) imgt:Segment_912_1|obo:BFO_0000050|imgt:Construct_912 imgt:Construct_697|obo:BFO_0000051|imgt:Segment_697_1 imgt:mAb_191|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=191 imgt:Segment_452_1|rdf:type|imgt:Segment imgt:FCER2|skos:definition|FCER2 (immunoglobulin E Fc receptor low affinity II, Fc epsilon RII, CD23) imgt:StudyProduct_ff02fdb0-13d8-318a-af5f-902f811d122b|imgt:application_type|Therapeutic imgt:IgG1-kappa_677|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:Clone_1289|obo:RO_0002162|imgt:Musmus imgt:Fibronectin-1Label|skos:definition|Fibronectin domains F1 very similar to a C-DOMAIN with big insertions imgt:mAb_774|rdf:type|imgt:INN imgt:4C-LIKE|skos:definition|Chain or receptor comprising four C-LIKE domains imgt:Cancers_head_and_neck|imgt:isClinicalIndicationOf|imgt:StudyProduct_3ddaf22c-92f7-3eaa-9933-8dc274f0f92e imgt:Celgene_corporation|imgt:produces|imgt:Product_1d8957b9-d04f-3bf2-9ecb-463987894434 imgt:StudyProduct_3f00c5d2-52d1-309d-857c-875e8e9304cf|imgt:hasClinicalIndication|imgt:Charcot-Marie-Tooth_(CMT)_disease imgt:StudyProduct_bf0c6988-2641-3c0a-8840-60eccf82f63b|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:Product_95f41e2a-be09-3c81-80de-1897a5986fef|rdf:type|obo:NCIT_C51980 imgt:Clone_125|imgt:isOriginCloneOf|imgt:mAb_125 imgt:Construct_721|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:StudyProduct_7cae7db3-e810-3407-a918-eb090cc1b252|imgt:application_type|Therapeutic imgt:IgG4-kappa_1066|rdf:type|imgt:MAbReceptor imgt:mAb_609|imgt:inn_recommended_list|76 (2016) imgt:IgG4-kappa_378|http://semanticscience.org/resource/SIO_000291|imgt:APP imgt:EGFR|imgt:isTargetOf|imgt:IgG1-kappa_433 imgt:Segment_818_2|obo:BFO_0000050|imgt:Construct_818 imgt:mAb_460|imgt:inn_number|9724 imgt:StudyProduct_25835666-f627-3743-aa83-e8ff38e5106a|rdfs:label|StudyProduct_25835666-f627-3743-aa83-e8ff38e5106a imgt:Severe_sepsis_and_early_septic_shock|imgt:clinical_domain|Immunology imgt:Segment_1226_1|rdf:type|imgt:Segment imgt:VH|rdf:type|imgt:V-DomainLabel imgt:mAb_1285|imgt:inn_name|trastuzumab corixetan imgt:Cancers_head_and_neck|imgt:isClinicalIndicationOf|imgt:StudyProduct_3309214d-18ef-35e6-8b89-8e5b98aafdff imgt:mAb_957|imgt:hasMabReceptor|imgt:IgG4-kappa_957 imgt:Product_49c2056b-e4db-3d7e-aeaa-1e329f6571e9|rdfs:label|Product_49c2056b-e4db-3d7e-aeaa-1e329f6571e9 imgt:IgG4-kappa_155|rdf:type|imgt:MAbReceptor _:Ba6dda752f5d72771a2e30578f8080a76|rdf:type|obo:NCIT_C53285 imgt:Intracranial_hemorrhage_(ICH)|imgt:isClinicalIndicationOf|imgt:StudyProduct_85f27b86-dd49-30eb-b046-b3920adebed7 imgt:Product_f13441d6-24fa-3bbd-8cf9-c42aef37f1b1|imgt:isProductOf|imgt:mAb_392 imgt:mAb_681|imgt:hasMabReceptor|imgt:PROTEIN_1DOMAIN-PEG_681 imgt:Product_d20addb4-f657-3cc7-982c-8be5405b1b3a|imgt:hasStudyProduct|imgt:StudyProduct_df66b8bb-9491-3583-a2b2-3342c5f2393a imgt:StudyProduct_c5774158-3f34-39b3-9850-003a4415fb21|imgt:isStudyProductOf|imgt:Product_c7be9dd8-8b8f-38bc-9841-af5bf6b87cd0 imgt:mAb_886|rdf:type|imgt:INN imgt:scFv-h-CH2-CH3_1189|imgt:hasMolecularComponent|imgt:IG obo:NCIT_C87768|rdf:type|owl:Class _:Bb4c36dd5bc023ee2de9d0c7d5afc9e4d|dc:date|2016-10-19 imgt:mAb_909|imgt:inn_number|10988 imgt:Product_5c35ec7d-f892-34d7-a57f-2709a11d3612|imgt:isProductOf|imgt:mAb_594 imgt:Construct_1256|rdf:type|imgt:Construct imgt:Acute_lymphocytic_leukemia_(ALL)|imgt:isClinicalIndicationOf|imgt:StudyProduct_0c373d90-768b-334b-9f1f-d5225dd3f2e3 imgt:StudyProduct_db1471ac-0b14-38e9-ae83-f5e6efc97f5f|rdfs:label|StudyProduct_db1471ac-0b14-38e9-ae83-f5e6efc97f5f imgt:H-GAMMA-2B|skos:definition|Ig-Heavy-Gamma-2B chain comprising VH, CH1, HINGE, CH2, CH3 and CHS domains imgt:StudyProduct_e2e0e4e8-186e-366d-bf96-3cdbf085e738|imgt:isStudyProductOf|imgt:Product_885d502e-12f5-381c-9601-6d157171b81e imgt:mAb_155|rdf:type|obo:NCIT_C172657 imgt:StudyProduct_c7982c10-665e-3ee2-b3d4-b98508bc7c3c|rdfs:label|StudyProduct_c7982c10-665e-3ee2-b3d4-b98508bc7c3c imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_b0068f1c-09c6-31a5-a114-bad6096c12c7 imgt:F(AB')2-GAMMA-3_LAMBDA|imgt:describes|imgt:F(ab’)2-Gamma-3_Lambda imgt:10663|rdf:type|obo:NCIT_C25402 _:B4e136a2dc204982f9b0f16221164035b|rdf:type|obo:NCIT_C53285 imgt:TYRP1|obo:RO_0002162|imgt:Homsap imgt:IG-GAMMA-1_LAMBDA-2|rdfs:label|IG-GAMMA-1_LAMBDA-2 imgt:Product_f573aa69-629e-35d8-890f-6f7dc4dc84d2|imgt:isProductOf|imgt:mAb_401 imgt:IG-GAMMA-3_KAPPA|rdf:type|imgt:StructureLabels imgt:mAb_397|imgt:inn_recommended_list|59 (2008) imgt:StudyProduct_f95e7e1c-4453-3bfe-835c-1245dfb30b90|imgt:application_type|Therapeutic imgt:IgG1-kappa_151|rdfs:label|IgG1-kappa_151 imgt:mAb_263|rdf:type|imgt:INN imgt:StudyProduct_3c33cf64-59ff-3621-8d4f-95a3d85afee6|imgt:hasClinicalPhase|imgt:Phase_IV imgt:Product_ee42c2a8-bd22-307b-8b06-6b191270e9a0|imgt:isProducedBy|imgt:Pfizer imgt:Product_6b42a0d3-1383-3dc2-a533-4f51868e60f6|imgt:commun_name|VAY-736 imgt:Segment_400_1|obo:BFO_0000050|imgt:Construct_400 imgt:StudyProduct_105a4697-29fc-3299-83ce-6af63d477662|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:StudyProduct_71af956f-bf2b-35b7-aff8-5a8adf09bfd5|imgt:hasClinicalPhase|imgt:Phase_III imgt:StudyProduct_faac2e57-fc8e-322b-b5e6-e0ba34ef089f|rdf:type|obo:NCIT_C174271 imgt:Product_6921438e-7c6b-3e42-bd7f-0e3bc47d6848|imgt:hasStudyProduct|imgt:StudyProduct_59edc1c8-0af5-39b0-9197-e5eeadad6f19 imgt:StudyProduct_c51d4fa7-6bdd-3cfc-9c62-a748ac70ea31|rdf:type|obo:NCIT_C174271 imgt:Segment_1124_2|obo:BFO_0000050|imgt:Construct_1124 imgt:mAb_398|imgt:hasImgtStructureEntry|imgt:8947 imgt:Product_69aca6bd-b362-373e-98be-9f1735773595|imgt:isProductOf|imgt:mAb_371 _:B1b1f6d8619a28a8b65ef36792f784c6b|dc:date|2017-08-30 imgt:Product_37e454ae-c400-32fb-913e-b064fbf26cc6|imgt:commun_name|serum amyloid P-component imgt:Crohn's_disease_(CD)|imgt:isClinicalIndicationOf|imgt:StudyProduct_c5074f11-9520-3726-bb53-f999c28df5fc imgt:TNFR-CYS|rdfs:label|TNFR-CYS imgt:mAb_777|imgt:inn_number|10674 obo:NCIT_C171700|rdf:type|owl:Class imgt:TGFB1|imgt:isTargetOf|imgt:IgG4-kappa_186 imgt:StudyProduct_5cd87dea-34f0-34e4-97ea-af0982f08b31|imgt:hasClinicalPhase|imgt:Phase_II imgt:IgG1-kappa_296|http://semanticscience.org/resource/SIO_000291|imgt:IGF1R imgt:mAb_392|imgt:inn_number|8337 imgt:Construct_13|obo:BFO_0000051|imgt:Segment_13_1 imgt:ERBB2|imgt:isTargetOf|imgt:IgG1-kappa_1171 _:Bb24448a4cdbde72d92bb3d0a311f7370|imgt:isDecisionOf|imgt:StudyProduct_3adc6318-e634-3534-9fb2-a10d3048eb2f imgt:hasImgtStructureEntry|rdfs:domain|obo:NCIT_C1909 imgt:StudyProduct_2dd3404f-1979-37e2-9af4-6960a4e508ea|imgt:isStudyProductOf|imgt:Product_9b5614c6-8750-39f5-8dfe-86ffd967ed48 imgt:StudyProduct_309cbdae-97a1-314b-83a0-f3f22f4b4747|imgt:hasClinicalIndication|imgt:Non-Hodgkin's_lymphoma_(NHL) imgt:H3|skos:definition|hinge exon 3 of IG heavy C-GENE-UNIT imgt:Product_165975b7-c4e2-3663-8b7e-03bb4d0ac418|imgt:hasStudyProduct|imgt:StudyProduct_769558a0-d1ae-3f69-b2ca-d770db4dbf13 imgt:StudyProduct_c4a58d65-10f4-386e-8564-cadd29a4fb1f|imgt:hasClinicalIndication|imgt:Solid_tumors imgt:D-J-CLUSTER|skos:definition|genomic DNA of an IG or TR locus, in germline configuration, including at least one D-GENE and one J-GENE imgt:Segment_396_2|rdf:type|imgt:Segment imgt:Product_a7783cec-9ac8-35f9-9629-3982e07c2ba0|imgt:hasStudyProduct|imgt:StudyProduct_7c02ae71-57b5-3268-83a4-424069d7d5c9 _:B55e7025d7bc807aa110512a4ea44fe81|imgt:hasDesignation|imgt:Orphan_drug imgt:11372|imgt:isImgtStructureEntryOf|imgt:mAb_1099 imgt:mAb_1173|imgt:hasImgtStructureEntry|imgt:11679 imgt:mAb_352|imgt:clinical_trials|33 studies found, 8 recruiting imgt:mAb_369|imgt:inn_number|9322 imgt:mAb_291|imgt:inn_number|9074 imgt:StudyProduct_8dbf6b8e-61d6-3faa-b68f-46ef365b37fb|rdfs:label|StudyProduct_8dbf6b8e-61d6-3faa-b68f-46ef365b37fb imgt:Product_aac2ba8b-69b0-31aa-b7c9-b2dc4b8f4de6|imgt:hasStudyProduct|imgt:StudyProduct_3d7a7c5d-f67d-3d22-acb3-8a9ceec296ee imgt:IgG1-lambda_235|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-lambda.png imgt:Product_2cc853dd-e3c6-3e19-a19e-85aa74315a15|imgt:hasStudyProduct|imgt:StudyProduct_6b12cc8b-fb90-35c4-9c2b-37dcf5c052cd imgt:Zaire_Ebola_virus|imgt:isTargetOf|imgt:IgG1-kappa_1114 imgt:MAbReceptor_202|rdfs:label|MAbReceptor_202 imgt:mAb_1016|imgt:hasProduct|imgt:Product_b902d379-45ba-3460-955c-938cf82600f1 imgt:IgG4-lambda_915|obo:RO_0002162|imgt:Hum imgt:CEACAM5|imgt:isTargetOf|imgt:MAbReceptor_62 imgt:8659|rdf:type|obo:NCIT_C25402 imgt:IG-GAMMA_LAMBDA|imgt:describes|imgt:IgG_Lambda imgt:MH2-Alpha-MH2-DA|rdf:type|imgt:GeneLevelChainType imgt:IgG1-lambda-4cys-drug_665|rdfs:label|IgG1-lambda-4cys-drug_665 imgt:mAb_1112|imgt:imgt_note| WHO Drug Information, Vol. 34, No. 3, 2020. Proposed INN List 124 – COVID-19 (special edition) (9 October 2020) pages 642-669. Proposed INN List 124 (19 December 2020, published on 22 January 2021) pages 929-1102. imgt:FPIA_%5BPROTEIN%5D2-FC_843|imgt:fused_with| Homo sapiens IGHG2 Fc (Fragment constant) imgt:frizzled_family_receptor_(FZD)|obo:RO_0002162|imgt:Homsap imgt:J-PHE|rdf:type|imgt:ConservedAALabel imgt:StudyProduct_7e9612a2-9c03-375f-9baa-d119aa6ee68c|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_10fe858f-824f-3374-b210-1fe3fe64531d|imgt:isStudyProductOf|imgt:Product_60d92d53-d63b-32a9-9c01-e5ac6fb8d93c imgt:Construct_935|obo:BFO_0000051|imgt:Segment_935_1 imgt:Severe_acute_respiratory_syndrome_(SARS)_infection|rdfs:label|Severe_acute_respiratory_syndrome_(SARS)_infection imgt:Product_6749bce5-ca17-3a1e-b6a6-716da8fc041b|imgt:commun_name|MDX-CD4 imgt:mAb_169|imgt:hasMabReceptor|imgt:IgG1-lambda_169 imgt:Product_ed1b4d51-6349-3a0c-b888-039ed6131076|imgt:isProducedBy|imgt:Roche_F_Hoffmann-La_Roche_Ltd imgt:mAb_1268|imgt:hasImgtStructureEntry|imgt:11951 imgt:mAb_1194|imgt:inn_proposed_list|125 (2021) imgt:StudyProduct_026b75f7-c995-3045-a2f6-daa0a331f298|imgt:application_type|Therapeutic imgt:Product_d7fdef9d-ffc1-3cfa-a0c4-55b5452505c5|imgt:comercial_name|ALBUFERON imgt:Product_c2a35708-7257-3084-8079-8ca3bcca6373|imgt:hasStudyProduct|imgt:StudyProduct_c15bccdd-bf01-38ee-b5a7-5a4e74d5fde2 imgt:mAb_835|imgt:hasImgtStructureEntry|imgt:10858 obo:NCIT_C166971|rdf:type|owl:Class imgt:Segment_901_1|imgt:has_rank|1 imgt:mAb_103|imgt:inn_number|8651 imgt:11046|rdfs:label|11046 imgt:mAb_472|imgt:hasImgtStructureEntry|imgt:9798 imgt:Severe_acute_respiratory_syndrome_coronavirus_2_(SARS-CoV-2)|imgt:isTargetOf|imgt:IgG1-kappa_1279 _:B2620cb60d40ca83eded43e696c909c45|imgt:hasDesignation|imgt:Orphan_drug imgt:IgM-nd_310|rdfs:comment|IgM - nd imgt:Product_78905744-ca8d-34e5-af60-99dbb915396d|imgt:hasStudyProduct|imgt:StudyProduct_d9a56cdb-aa81-30ba-9e20-78c4bd03b8f4 imgt:mAb_957|rdfs:label|mAb_957 imgt:TR-Gamma-2-TRGC2|rdfs:label|TR-Gamma-2-TRGC2 imgt:10803|rdfs:label|10803 imgt:IgG4-kappa_898|imgt:hasConstruct|imgt:Construct_898 imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_aaf34cfb-ccb6-39bf-a6ae-0c91c314772d imgt:StudyProduct_6b12cc8b-fb90-35c4-9c2b-37dcf5c052cd|rdfs:label|StudyProduct_6b12cc8b-fb90-35c4-9c2b-37dcf5c052cd imgt:Product_7a590139-a8dc-33f6-b868-ffaa80fc628a|imgt:hasStudyProduct|imgt:StudyProduct_9937a441-0ec1-3a63-aad1-05d1c815f902 imgt:mAb_608|imgt:inn_recommended_list|78 (2017) imgt:Product_a461e569-39a0-3c1c-8ef1-e32c2837aaa7|imgt:hasStudyProduct|imgt:StudyProduct_5ff03aa4-c1a6-333f-bab6-96c68bad5a17 imgt:FPIA_%5BPROTEIN_3DOMAINS_3CLIKE-PROTEIN_3DOMAINS_3CLIKE%5D2-FC_217|imgt:isMabReceptorOf|imgt:mAb_217 imgt:Product_8a1b8bbe-2945-3cb5-b953-e62a4fdd3269|imgt:commun_name|STIM003 imgt:2C-LIKE|rdfs:label|2C-LIKE imgt:Product_dfacdb0c-b486-3d1e-aa2b-38d3b8a8a4ee|imgt:commun_name|IDEC-114 imgt:Product_7206ce92-2c30-3a53-96b4-d2f0bd2f1dd3|imgt:commun_name|IBI 939 imgt:10973|rdf:type|obo:NCIT_C25402 imgt:Product_19be9437-f626-344b-9200-e7b704079fdb|imgt:commun_name|RO7227166 imgt:HBV|skos:definition|HBV (hepatitis B virus) imgt:StudyProduct_e465dd93-a9f9-3a4a-b21b-b3aa05e08da9|imgt:hasClinicalPhase|imgt:Phase_I imgt:8869|rdf:type|obo:NCIT_C25402 imgt:Construct_970|imgt:isConstructOf|imgt:IgG4-kappa_970 imgt:Construct_1295|imgt:hasImgtLabel|imgt:LCN2_(lipocalin_2) imgt:1C-LIKE|rdf:type|imgt:ChainLabels imgt:Segment_820_1|imgt:has_rank|1 imgt:Construct_418|rdfs:label|Construct_418 imgt:TNF|imgt:isTargetOf|imgt:FPIA_%5BPROTEIN_4REPEATS%5D2-3S-FC_733 imgt:Product_0dc35379-efa3-32cf-93ef-6c88dcbb0baf|imgt:isProductOf|imgt:mAb_147 pubmed:648586|dc:contributor|Nozaki M imgt:Segment_230_1|obo:BFO_0000050|imgt:Construct_230 imgt:Segment_694_2|rdfs:label|Segment_694_2 imgt:SAA1|imgt:isTargetOf|imgt:IgG1-kappa_619 imgt:StudyProduct_b446062e-05b8-397d-92a8-a54a2fb2ab92|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_09b6a2e9-00c3-3e0c-bed9-f7b4114a276a|imgt:application_type|Therapeutic imgt:Construct_941|obo:BFO_0000051|imgt:Segment_941_1 imgt:Hemophilia_B_(control_and_prevention_of_bleeding_episodes)|imgt:isClinicalIndicationOf|imgt:StudyProduct_a09699b6-3df5-36aa-8724-b398d8742a93 imgt:Product_e486c14a-a89f-327e-8f36-b95267609593|imgt:isProducedBy|imgt:Regeneron_Pharmaceuticals_Inc imgt:IgG1-kappa_379|rdfs:label|IgG1-kappa_379 imgt:mAb_869|rdf:type|obo:NCIT_C124229 imgt:Segment_331_1|imgt:has_rank|1 imgt:StudyProduct_946f07c9-d4f0-31e7-93ab-c6d674e08dd4|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_7b9bd74a-b763-35c0-949a-2f2387ddcbfe|imgt:isStudyProductOf|imgt:Product_29ed30a2-7708-3212-b64a-672c17f2dab4 imgt:IgG1-kappa_1070|imgt:hasConstruct|imgt:Construct_1070 imgt:Elan_Pharmaceuticals_International_Ltd|rdf:type|obo:NCIT_C54131 imgt:StudyProduct_baec2f65-4160-3b27-b529-a70a14c5af0f|imgt:application_type|Therapeutic imgt:VH-CH1-VH-V-KAPPA-CH2-CH3_953|imgt:hasConstruct|imgt:Construct_953 imgt:StudyProduct_3a9f50d7-b150-3a63-a2a7-78541cfc65d9|imgt:application_type|Therapeutic imgt:mAb_1268|imgt:hasProduct|imgt:Product_d279ead2-db0d-31e8-b926-370dcdea07b4 imgt:StudyProduct_6e1d6f70-6543-3bce-a73d-eacbc56df1a3|imgt:isStudyProductOf|imgt:Product_538ab0c9-c52c-3c61-ae4c-1c89532b23a7 imgt:StudyProduct_3f7a0a09-5aa7-36c1-be82-035bbcbc3190|imgt:hasExpressionSystem|imgt:_Hybridoma_P3X63 imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_7a967703-290b-3e04-89fc-4cd1051440a7 imgt:10537|rdfs:label|10537 imgt:FUSION-%5BSELPLG%5D2-FC-GAMMA-1|skos:definition|Fusion protein for immune application (FPIA) comprising SELPG fused with immunoglobulin G1 FC fragment imgt:L-IOTA-1|rdfs:label|L-IOTA-1 imgt:StudyProduct_72189fbf-3bee-3734-b92b-10895d2c122d|imgt:isStudyProductOf|imgt:Product_07a0f8df-d456-3179-a3a2-ab802e7d3e13 imgt:Product_5434bb15-0743-328f-bf03-72722410825d|rdf:type|obo:NCIT_C51980 imgt:Segment_374_1|rdfs:label|Segment_374_1 imgt:Product_463a66bb-9d66-383f-941e-52398ad21a7e|imgt:isProducedBy|imgt:University_of_Aberdeen imgt:C-REGION|rdfs:label|C-REGION imgt:Product_b73d2d86-860f-31ba-ad24-b3f898e384da|imgt:isProducedBy|imgt:Seattle_genetics_Inc imgt:IgG2a-kappa/G2b-lambda|imgt:construction_detail|IgG2a - kappa / G2b - lambda imgt:Construct_475|obo:BFO_0000051|imgt:Segment_475_1 imgt:(VH-CH2-CH3)2_S_1220|rdfs:label|(VH-CH2-CH3)2_S_1220 imgt:StudyProduct_bcd84b48-b116-3270-92e4-33d66f0c7e74|imgt:isStudyProductOf|imgt:Product_3ed1f3fa-f665-3b01-944a-008c6983dd4c imgt:Construct_1032|rdfs:label|Construct_1032 imgt:StudyProduct_56910023-f831-3f31-a66c-2f627228bcc5|rdf:type|obo:NCIT_C174271 imgt:Construct_1161|imgt:isConstructOf|imgt:scFv-heavy-kappa-scFv-kappa-heavy-CD8A(CO-TM)-TNFRSF9(CY)-CD247_1161 imgt:Segment_70_1|obo:BFO_0000050|imgt:Construct_70 imgt:Segment_152_1|obo:BFO_0000050|imgt:Construct_152 imgt:mAb_870|imgt:inn_recommended_list|81 (2019) imgt:Product_a485a257-0ee7-3b5b-836e-05670bd746d8|imgt:commun_name|BTCT4465A imgt:Construct_653|obo:BFO_0000051|imgt:Segment_653_1 imgt:StudyProduct_2a63fd24-af5c-31ed-9c46-cda848997546|rdf:type|obo:NCIT_C174271 imgt:Segment_546_2|imgt:has_rank|2 imgt:mAb_463|rdfs:label|mAb_463 imgt:StudyProduct_5dc76bb1-18f7-3f8f-8690-147217414e5e|imgt:isStudyProductOf|imgt:Product_90e11668-63b2-3af3-a7d4-2217cda61a3f imgt:StudyProduct_dd32b9ab-1c56-36d1-bfba-8116f809cfa0|imgt:hasClinicalIndication|imgt:Psoriasis imgt:Product_0e71815e-bc5c-3088-87f0-5fb9ca2d7a89|imgt:isProductOf|imgt:mAb_400 imgt:Segment_17_1|imgt:has_rank|1 imgt:Product_32072254-9d17-31cf-bf24-7855f937b982|imgt:isProductOf|imgt:mAb_320 imgt:TaxonomyRelated_StructureType|dc:identifier|imgt_000303 imgt:Product_50c591cd-103a-3ec1-b4c9-d3d55b7a0ca4|imgt:commun_name|IGN002 imgt:StudyProduct_b61f946d-b608-3531-851b-b002dcaad596|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_95f8f51f-1152-388e-b759-713b64855faf|rdf:type|obo:NCIT_C174271 imgt:IgG4-kappa_864|rdf:type|imgt:MAbReceptor imgt:mAb_746|rdfs:label|mAb_746 imgt:StudyProduct_8c1b462f-c962-344a-9c3d-afcb903712e3|imgt:isStudyProductOf|imgt:Product_a8c8c8c2-d189-3ad8-a6d9-9c8f8d8c89c0 imgt:hasImgtLabel|skos:definition|Link feature to its label w.r.t of IMGT standardization imgt:11952|rdfs:label|11952 imgt:Product_39647f9c-5a2a-3d4d-b584-bce5721f1fed|imgt:isProducedBy|imgt:Amgen _:Bc5cfbf02cf6038f0b95bcb2e41df131e|imgt:hasStatut|imgt:approval imgt:IgG2a-kappa_125|obo:RO_0002162|imgt:Musmus imgt:FV-HEAVY_LAMBDA|skos:definition|Fv comprising a VH and a V-LAMBDA domains pubmed:8652509|imgt:isBibliographicReferenceOf|imgt:mAb_725 imgt:Segment_1229_1|rdf:type|imgt:Segment imgt:Thermal_injury|rdf:type|obo:NCIT_C185637 imgt:CH9|rdf:type|imgt:C-DomainLabel imgt:IgG2-kappa_363|rdfs:label|IgG2-kappa_363 imgt:Product_406390c3-6cd8-3629-be68-66016fce19cf|imgt:hasStudyProduct|imgt:StudyProduct_c6695b95-8579-3d6e-8979-be659fbc07b6 imgt:9053|imgt:isImgtStructureEntryOf|imgt:mAb_90 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imgt:Construct_708|imgt:hasImgtLabel|imgt:IL1RN_(interleukin_1_receptor_antagonist_IL1RA_IL-1RN_%22interleukin-1_receptor_antagonist_protein%22)_recombinant_non_glycosylated imgt:mAb_1113|imgt:hasMabReceptor|imgt:FPIA_%5BPROTEIN%5D2-FC_1113 imgt:IgG4-kappa_472|rdfs:label|IgG4-kappa_472 imgt:Segment_1130_1|imgt:has_rank|1 imgt:StudyProduct_8dbf6b8e-61d6-3faa-b68f-46ef365b37fb|imgt:hasExpressionSystem|imgt:_CHO-K1 imgt:Construct_658|rdf:type|imgt:Construct imgt:Construct_1004|rdf:type|imgt:Construct imgt:Product_58a44815-3c5a-344f-960b-2c9d9ab2ae6d|imgt:hasStudyProduct|imgt:StudyProduct_15335a0b-21d4-30ab-baca-3f098f84411e imgt:PROTEIN_1DOMAIN_778|http://semanticscience.org/resource/SIO_000291|imgt:EPOR imgt:Construct_679|imgt:isConstructOf|imgt:VH-VL-VH%27-VL%27_679 imgt:StudyProduct_7f63e836-5b8c-308d-97f6-a77b5d984e21|imgt:isStudyProductOf|imgt:Product_0650976e-e362-337e-ab9a-2cf669b1c2b0 imgt:Product_3c62c1d3-6697-377e-b40d-3cf466d466f6|rdfs:label|Product_3c62c1d3-6697-377e-b40d-3cf466d466f6 imgt:StudyProduct_4b3ccea3-961f-3102-9e9c-20f015542dfe|imgt:isStudyProductOf|imgt:Product_3fbfe977-f5f9-381b-94d0-489e229f2eaf obo:NCIT_C166806|rdf:type|owl:Class imgt:StudyProduct_f765eebb-5180-3806-84f0-27613a9fb127|imgt:application_type|Therapeutic imgt:StudyProduct_e672be16-de9f-37bd-a0e8-3f96dfdbe39d|imgt:hasClinicalPhase|imgt:Phase_I/II imgt:mAb_608|rdf:type|obo:NCIT_C121376 imgt:2XA8|rdf:type|obo:NCIT_C25402 imgt:StudyProduct_0b960111-911b-397c-80ea-abee4766eb34|rdfs:label|StudyProduct_0b960111-911b-397c-80ea-abee4766eb34 imgt:Construct_821|imgt:hasImgtLabel|imgt:%5BTNFRSF1B_(tumor_necrosis_factor_receptor_(TNFR)_superfamily_member_1B_TNFBR_p75_CD120b)%5D2-IGHG1_Fc_(Fragment_constant) imgt:mAb_225|imgt:hasProduct|imgt:Product_b7a7e4bb-f8f0-300e-9c56-2377c788b72a pubmed:2451287|dc:contributor|Milstein C. imgt:mAb_1157|imgt:imgt_note| WHO Drug Information, Vol. 34, No. 3, 2020. Proposed INN List 124 – COVID-19 (special edition) (9 October 2020) pages 642-669. Proposed INN List 124 (19 December 2020, published on 22 January 2021) pages 929-1102. eramkafusp alfa consist of an anti-CD20 monoclonal antibody (rituximab) fused to interferon alpha (IFNA2) using a short peptide linker SGGGGS. imgt:StudyProduct_c7f183f5-16c3-306a-be1d-ef45499042d2|rdfs:label|StudyProduct_c7f183f5-16c3-306a-be1d-ef45499042d2 imgt:IgG1-kappa-4cys-drug_532|rdf:type|imgt:MAbReceptor imgt:Hairy_cell_leukemia_(HCL)|imgt:isClinicalIndicationOf|imgt:StudyProduct_45b63be0-6516-3287-a513-78eea2ee1562 imgt:mAb_162|imgt:hasProduct|imgt:Product_ccfd4bb7-d8bd-302b-8b17-e3329a65fcc8 imgt:11721|imgt:isImgtStructureEntryOf|imgt:mAb_1231 imgt:Product_48a3e4f4-bc9a-3246-8b3d-6b922a64162b|rdfs:label|Product_48a3e4f4-bc9a-3246-8b3d-6b922a64162b imgt:Clone_1158|imgt:clone_name|RC28-E062A2034S imgt:IgG2-kappa_1170|obo:RO_0002162|imgt:Hum imgt:Migraine|imgt:isClinicalIndicationOf|imgt:StudyProduct_e76dd271-b84f-3aaf-b1f8-6154e72d3c61 _:Bff17f71910ba5c1bb333786d7b12098b|dc:date|2015-11-23 imgt:StudyProduct_f125f536-cb07-3d41-9944-5fae1929288e|imgt:hasClinicalPhase|imgt:Phase_II imgt:FUSION-IL2-GAMMA-1|skos:definition|IL2 fused with G1 H-CH2-CH3 imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_e9448e9b-2d6c-31a8-a5fa-b02d1a05de2a imgt:StudyProduct_99437481-72fe-3999-af98-dd27259f1f62|rdfs:label|StudyProduct_99437481-72fe-3999-af98-dd27259f1f62 imgt:mAb_88|rdf:type|imgt:INN imgt:IgG1-kappa_234|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:Product_f6eddd34-803e-38c4-988e-4fdccd05fd3b|imgt:commun_name|MEDI2070 imgt:FUSION-SCFV-HEAVY-KAPPA-IL2|rdf:type|imgt:ChainLabels imgt:AstraZeneca|imgt:produces|imgt:Product_e457f880-631c-3188-aa6a-c8ab128920c4 imgt:1C-LIKE-3F-DOMAIN|rdf:type|imgt:RPILabel imgt:LukGH|rdfs:label|LukGH imgt:IgG2-kappa-4cys-drug_772|rdfs:label|IgG2-kappa-4cys-drug_772 imgt:ERBB2|imgt:isTargetOf|imgt:IgG1-kappa_1122 imgt:Product_92b259d6-26a2-3e90-b3f3-a59104dd74f7|imgt:commun_name|GLP-1Fc imgt:StudyProduct_26f816cb-d7cc-3323-8ff2-a13cee4d35ca|imgt:isStudyProductOf|imgt:Product_b73d2d86-860f-31ba-ad24-b3f898e384da imgt:IgG2b-kappa_991|rdfs:label|IgG2b-kappa_991 imgt:scFv-kappa-heavy-IGHG4_h_(CO)-CD28_(TM)-TNFRSF9_(CY)_CD247-TEApep-EGFRt_874|rdf:type|imgt:MAbReceptor imgt:%5B(scFv-heavy-kappa)-IGHE-CH4%5D2_370|http://semanticscience.org/resource/SIO_000291|imgt:FN_(fibronectin) imgt:Melanoma|rdfs:label|Melanoma imgt:F11|imgt:isTargetOf|imgt:IgG1-kappa_857 imgt:StudyProduct_43484832-71db-3790-b17a-351b54b3d17a|imgt:hasClinicalIndication|imgt:Psoriasis imgt:StudyProduct_ec44632e-85a9-3925-a446-75a4f03602f3|imgt:application_type|Therapeutic imgt:Synthetic_Biologics_Inc|imgt:produces|imgt:Product_5fa85db2-30f3-3bc1-b3dd-17ad4f3c942c imgt:PROTEIN_2DOMAINS_933|rdfs:label|PROTEIN_2DOMAINS_933 obo:NCIT_C156017|rdfs:subClassOf|obo:NCIT_C1909 imgt:StudyProduct_3ff2cb83-f81b-3da6-9128-579440ac058a|imgt:application_type|Therapeutic pubmed:16697465|dc:contributor|Bruckmaier S imgt:mAb_525|imgt:hasProduct|imgt:Product_55641d75-4bea-3672-954b-a633026b9972 imgt:Segment_190_1|imgt:hasImgtLabel|imgt:IgG1-nd pubmed:7695263|dc:contributor|Mittler ES obo:NCIT_C26449|rdf:type|owl:Class imgt:StudyProduct_5bd00c15-5132-3b98-92ad-994980aadd96|imgt:hasExpressionSystem|imgt:_NS0_mouse_myeloma_cells imgt:Segment_56_1|obo:BFO_0000050|imgt:Construct_56 imgt:mAb_301|rdf:type|imgt:INN imgt:ClassLevelChainType|rdf:type|owl:Class imgt:FUSION-FC-GAMMA-4-%5BTRAF2-TNFSF4%5D2|rdfs:label|FUSION-FC-GAMMA-4-[TRAF2-TNFSF4]2 imgt:mAb_265|imgt:imgt_note| CAS number : 502496-16-4, Composition : C6414 H9934 N1718 O2010 S40 imgt:IgG1-lambda|imgt:construction_detail|IgG1 - lambda imgt:StudyProduct_3b49444b-27d5-3009-9948-320cd9518ba7|rdf:type|obo:NCIT_C174271 imgt:mAb_1068|imgt:inn_proposed_list|123 (2020) imgt:mAb_81|imgt:hasProduct|imgt:Product_67bd7f52-411a-3222-8c8e-7f9687f922eb imgt:VZV_(envelope_glycoprotein_H)|imgt:isTargetOf|imgt:IgG1-nd_440 imgt:IgG1-kappa_1023|obo:RO_0002162|imgt:Hum imgt:TNFRSF17|imgt:isTargetOf|imgt:scFv-heavy-kappa-CD8A_(CO-TM)-TNFRSF9_(CY)-CD247_1230 imgt:Segment_583_1|imgt:hasImgtLabel|imgt:VH-VH-VH imgt:mAb_977|rdfs:label|mAb_977 imgt:Segment_216_2|imgt:segment_detail|Fc (Fragment constant) imgt:mAb_618|imgt:inn_proposed_list|115 (2016) imgt:Solid_tumors|imgt:isClinicalIndicationOf|imgt:StudyProduct_7a8a4321-2c20-3c9b-b98e-ac1a3008529e imgt:F(ab’)2-Alpha-1_Kappa|imgt:isDefinedBy|imgt:IG-Light-Kappa-IGKC imgt:StudyProduct_6426c0e3-845f-3486-8395-327590472c1e|rdf:type|obo:NCIT_C174271 imgt:Product_550b04fe-bcb2-3cf8-ab43-92130dafa2b3|imgt:commun_name|PR-1283233 _:B962f24c63ef3479c302471fe76ef9c4b|dc:date|2021-06-07 imgt:StudyProduct_c986d0a4-d7b4-3e39-a59f-c99f231921e9|rdf:type|obo:NCIT_C174271 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imgt:Age-related_macular_degeneration_(AMD)_geographic_atropy_(GA)_(dry_advanced_form)|imgt:clinical_domain|Ophthalmology imgt:Lymphoma_primary_mediastinal_B_cell_(PMBL)|rdfs:label|Lymphoma_primary_mediastinal_B_cell_(PMBL) imgt:mAb_329|imgt:inn_recommended_list|63 (2010) imgt:StudyProduct_d51f2da4-db5f-3ef5-be58-0680a7bca194|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:mAb_406|imgt:imgt_note| Genentech Inc. is a member of Roche Group since March 26, 2009. imgt:StudyProduct_33a1b4cd-f6bd-33f9-a1fc-87fe2b1244ca|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_89fa8513-4260-38ca-9cb8-762f0d2cc377|imgt:isStudyProductOf|imgt:Product_394a3a14-77f4-3e75-bfe2-0af838e9926b imgt:Product_d4a38f5a-7adc-3e81-9fb9-4d3d7818a952|imgt:isProducedBy|imgt:Jiangsu_Hengrui_Medicine_Co_Ltd imgt:11565|imgt:isImgtStructureEntryOf|imgt:mAb_1119 imgt:Alkermes_Inc|imgt:produces|imgt:Product_c4ad3947-577f-31a6-9ca5-62124b9ab8cf imgt:10165|rdf:type|obo:NCIT_C25402 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imgt:mAb_121|rdf:type|obo:NCIT_C1909 imgt:IG-Light-Iota-IGI|rdf:type|imgt:ChainType imgt:MSTN|imgt:isTargetOf|imgt:FPIA_%5BPROTEIN%5D2-FC_843 imgt:mAb_780|imgt:hasProduct|imgt:Product_90e11668-63b2-3af3-a7d4-2217cda61a3f imgt:StudyProduct_6a8a9e2e-2b56-336b-b146-1e73cbaccb25|imgt:isStudyProductOf|imgt:Product_12e83c22-d0d4-30c2-8197-cc9eececef54 imgt:Myelodysplastic_syndromes_(MDS)|imgt:isClinicalIndicationOf|imgt:StudyProduct_f0b8db0f-c770-338b-9507-40d0d2a0c9b3 imgt:mAb_1004|rdf:type|imgt:INN _:B10f5ecdbcafe82c4b50c540c587ccbb9|imgt:hasStatut|imgt:withdrawal imgt:IgG4-kappa_606|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG4-kappa.png imgt:Clone_108|rdf:type|obo:NCIT_C37925 imgt:IG-Heavy|rdf:type|imgt:ChainType imgt:IgG1-lambda_1022|http://semanticscience.org/resource/SIO_000291|imgt:CD274 imgt:Crohn's_disease_(CD)|imgt:isClinicalIndicationOf|imgt:StudyProduct_b87ee559-aea6-37ce-82b5-a1c9e1c007a2 imgt:%5BAXL_(AXL_receptor_tyrosine_kinase_ARK_JTK11_Tyro7_UFO)%5D2-IGHG1_Fc_(Fragment_constant)|imgt:construction_detail|Fusion - [AXL (AXL receptor tyrosine kinase, ARK, JTK11, Tyro7, UFO)]2 - IGHG1 Fc (Fragment constant) imgt:mAb_1174|rdf:type|imgt:INN imgt:Segment_651_1|rdf:type|imgt:Segment _:Bb75820f862cd825bb21e05bebbed8c18|imgt:isDecidedBy|imgt:FDA imgt:Segment_555_1|imgt:has_rank|1 imgt:B_cell_lymphoma|imgt:clinical_domain|Hematology imgt:StudyProduct_470fba3c-c13f-3b6a-b2a8-d44d7213ccc6|imgt:isStudyProductOf|imgt:Product_69f2feec-1ed2-3d80-9a95-8377b7888856 pubmed:27144973|dc:contributor|Gonzalez A imgt:Construct_1003|imgt:isConstructOf|imgt:IgG1-kappa_1003 imgt:StudyProduct_1245f7ca-ccb2-393f-9b53-4db15adb0ce2|rdfs:label|StudyProduct_1245f7ca-ccb2-393f-9b53-4db15adb0ce2 imgt:FPIA_%5BFC-%5BPEPTIDE-PROTEIN%5D2%5D3_998|rdf:type|imgt:MAbReceptor imgt:StudyProduct_a6379966-3f78-33e3-95cc-01bd8510d32a|rdf:type|obo:NCIT_C174271 imgt:Product_31c76a78-4c41-3e46-80fd-2ed38c0b8459|imgt:commun_name|rFIX-HSA imgt:Mesothelioma_malignant|imgt:isClinicalIndicationOf|imgt:StudyProduct_7a34b138-251b-35be-8436-2c6dc1728af2 imgt:Genentech_Inc|imgt:produces|imgt:Product_5ce3b46d-9c42-34a1-a25d-2571a2d48a7a imgt:IgG1-kappa_MM_138|http://semanticscience.org/resource/SIO_000291|imgt:tumour_associated_glycoprotein_72 imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_a1e1919e-055c-39d7-be00-d35393a10a71 imgt:StudyProduct_094bbabf-87fa-3f74-8c08-4fb2775296d8|imgt:application_type|Therapeutic imgt:IgG1-kappa_764|imgt:isMabReceptorOf|imgt:mAb_764 _:B146ef11d7eb0000eeee448015f51d805|imgt:hasStatut|imgt:approval imgt:Product_5cde7219-6367-3651-8ae8-f6c007a0a286|imgt:isProducedBy|imgt:Roche_F_Hoffmann-La_Roche_Ltd imgt:Segment_1021_1|obo:BFO_0000050|imgt:Construct_1021 imgt:mAb_223|imgt:inn_proposed_list|108 (2012) imgt:mAb_446|imgt:inn_recommended_list|70 (2013) obo:NCIT_C170383|rdfs:subClassOf|obo:NCIT_C1909 imgt:Segment_660_1|imgt:has_rank|1 _:Bce2f42a1b959292050dd6a0d1fae8689|imgt:isDecidedBy|imgt:FDA imgt:StudyProduct_3d7a7c5d-f67d-3d22-acb3-8a9ceec296ee|imgt:hasClinicalPhase|imgt:Phase_III imgt:StudyProduct_b0087114-0cf2-333e-b7a1-d7921ad26553|rdfs:label|StudyProduct_b0087114-0cf2-333e-b7a1-d7921ad26553 _:B592a0e47c5d4ab617bc89506fa73920e|imgt:isDecidedBy|imgt:FDA imgt:(scFv-heavy-kappa)-(scFv-heavy-lambda)_1057|rdf:type|imgt:MAbReceptor imgt:Construct_913|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:mAb_674|rdf:type|obo:NCIT_C124657 imgt:F(ab%27)2-G1-nd_123|imgt:hasMolecularComponent|imgt:IG imgt:mAb_415|rdf:type|imgt:INN imgt:Product_d3c2662f-9244-388c-aa91-aa125c885265|rdfs:label|Product_d3c2662f-9244-388c-aa91-aa125c885265 imgt:PROTEIN_1DOMAIN_917|rdfs:label|PROTEIN_1DOMAIN_917 imgt:MS4A1|imgt:isTargetOf|imgt:IgG1-kappa-%5BPROTEIN%5D2_IFNA2_1157 imgt:MAbReceptor_346|imgt:via_a| cleavable maleimidocaproyl-valyl-citrullinyl-p-aminobenzyloxycarbonyl (mc-val-cit-PABC) type linker imgt:mAb_553|imgt:hasProduct|imgt:Product_38dcb3a9-d366-365a-80b8-285719fdf525 imgt:Product_0e78d35e-30de-3c24-864a-dd1796feff85|rdfs:label|Product_0e78d35e-30de-3c24-864a-dd1796feff85 imgt:mAb_837|rdf:type|obo:NCIT_C1909 imgt:mAb_105|rdfs:label|mAb_105 imgt:(Fab-G1-kappa)-(Fc-G1)|rdf:type|imgt:SegmentLabels imgt:Segment_1218_1|imgt:hasImgtLabel|imgt:IgG4-kappa imgt:Segment_348_1|imgt:hasImgtLabel|imgt:IgG1-lambda imgt:9185|rdf:type|obo:NCIT_C25402 imgt:Neuromyelitis_optica_(NMO)|imgt:isClinicalIndicationOf|imgt:StudyProduct_6e0d7ab7-1246-3ec0-adef-e0cc395836aa pubmed:24927856|dc:contributor|Tarantolo SR imgt:Iba_Molecular_Imaging|rdfs:label|Iba Molecular Imaging imgt:StudyProduct_d41df579-0a6a-3c21-b92f-531508ff83c7|rdfs:label|StudyProduct_d41df579-0a6a-3c21-b92f-531508ff83c7 imgt:Segment_212_1|rdf:type|imgt:Segment imgt:Segment_377_1|obo:BFO_0000050|imgt:Construct_377 imgt:11020|rdf:type|obo:NCIT_C25402 imgt:IgG1-kappa_1105|obo:RO_0002162|imgt:Homsap imgt:4A-DOMAIN-PEPTIDASE-S1|rdfs:label|4A-DOMAIN-PEPTIDASE-S1 imgt:V-RS|rdf:type|imgt:RSLabel imgt:Segment_571_1|rdfs:label|Segment_571_1 imgt:VH-VH%27-h-CH2-CH3_1127|obo:RO_0002162|imgt:Chi imgt:HIV-1_infection_AIDS|imgt:isClinicalIndicationOf|imgt:StudyProduct_59a5eaf5-d39e-3d53-9166-ffcf09d837e9 imgt:Product_6921438e-7c6b-3e42-bd7f-0e3bc47d6848|imgt:hasStudyProduct|imgt:StudyProduct_b02fd50f-696c-3bb6-b7c8-73f2fa82adcd imgt:ITGAV_ITGB3|obo:RO_0002162|imgt:Homsap imgt:StudyProduct_9d7ec8b0-3345-3ffa-9904-622fa82f62b8|imgt:application_type|Therapeutic imgt:toxin_(Pr1_26-411)|rdfs:label|toxin (Pr1, 26-411) imgt:Clone_221|imgt:clone_name|CC49 imgt:Construct_407|rdf:type|imgt:Construct imgt:StudyProduct_55e7541c-3eab-3d0c-9193-6cda10fdcba2|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_a5041f6f-38ad-36eb-8be8-2917d0dd8a6b|imgt:hasClinicalPhase|imgt:Phase_M _:B006945158199dca532098d6d4eaf1361|imgt:hasDesignation|imgt:Orphan_drug imgt:IG-DELTA_KAPPA|rdf:type|imgt:IGCompleteReceptorLabel imgt:StudyProduct_233122d6-a975-377b-8d6a-a86d5c73aa72|imgt:isStudyProductOf|imgt:Product_25709140-bbc7-373c-9a44-2be9be3d8e9d imgt:Kenta_Biotech_Ltd|rdfs:label|Kenta Biotech Ltd imgt:IgG1-kappa_1275|rdf:type|imgt:MAbReceptor imgt:bispecific|imgt:isTargetOf|imgt:IgG2-kappa_1202 imgt:mAb_1034|rdf:type|imgt:INN imgt:C-transcript|skos:definition|Identifies, for mRNA, molecule entities with a C region in undefined configuration. C-transcript is in undefined configuration. imgt:Segment_531_1|imgt:has_rank|1 imgt:FAB-ALPHA-2_KAPPA|rdf:type|imgt:StructureLabels imgt:mAb_198|rdf:type|obo:NCIT_C68819 obo:NCIT_C2268|rdf:type|owl:Class imgt:Segment_733_1|rdfs:label|Segment_733_1 imgt:StudyProduct_e9fde481-76d5-3f46-ac81-d553a0f4bfdc|imgt:hasClinicalIndication|imgt:Asthma_severe_persistent imgt:mAb_801|imgt:hasMabReceptor|imgt:IgG1-kappa_801 imgt:Henlix_Inc|rdf:type|obo:NCIT_C54131 imgt:Construct_1200|imgt:hasImgtLabel|imgt:(scFv-heavy-lambda)-(scFv-heavy-lambda)-scFc imgt:Product_d8f8f32a-4a56-3077-910a-bd55a9d0cae3|imgt:isProductOf|imgt:mAb_1233 imgt:IL36RN|skos:definition|IL36RN (IL1F5, interleukin 1 family, member 5 (delta)) imgt:mAb_214|imgt:inn_recommended_list|57 (2007) imgt:StudyProduct_4782b1c1-f2ea-311e-ba07-ac9afd5f009b|imgt:hasClinicalPhase|imgt:Phase_II imgt:Product_2f33022b-bbc0-3f59-bc75-86deb8919d2c|imgt:comercial_name|ALLOMUNE™ imgt:StudyProduct_5893f77a-8ead-33d5-accb-55e4c2563b5d|imgt:isStudyProductOf|imgt:Product_d1cda899-6b1f-3fc5-9c4c-cb14c62b0c13 imgt:Construct_1173|imgt:hasImgtLabel|imgt:IgG4-kappa imgt:StudyProduct_3413c33b-a4b2-365e-9fa5-d378577a0308|rdf:type|obo:NCIT_C174271 imgt:Product_b1370aed-0f04-32a5-9fa3-29cf7e6cb0c7|imgt:isProductOf|imgt:mAb_709 imgt:Leap_Therapeutics|rdf:type|obo:NCIT_C54131 _:Bafb0b015d0ec0e82b3a08dd76968924a|dc:date|2018-09-28 _:B7c505214f888e6446faca8c0560b626f|imgt:isDecisionOf|imgt:StudyProduct_2043e7aa-cb22-378a-a1d8-1630b3306bcd imgt:IgG1-kappa_1193|rdf:type|imgt:MAbReceptor imgt:mAb_1280|imgt:hasProduct|imgt:Product_c67d4f68-56c4-3c24-8eaa-730b7fd45aaf imgt:isStudyProductOf|rdf:type|owl:ObjectProperty imgt:Construct_663|imgt:isConstructOf|imgt:IgG1-kappa_MM_663 imgt:scFv-heavy-kappa-CD8A_(CO-TM)-TNFRSF9_(CY)-CD247_1231|imgt:hasConstruct|imgt:Construct_1231 _:B42b89728a371f703c0e4a906a9738ba3|imgt:isDecisionOf|imgt:StudyProduct_9800c448-f4ee-3249-9e9a-fb121a3ddbae imgt:mAb_662|imgt:hasImgtStructureEntry|imgt:10420 imgt:Product_d162eac6-223f-3784-93c7-8637ba2b95cc|rdfs:label|Product_d162eac6-223f-3784-93c7-8637ba2b95cc imgt:StudyProduct_735319b1-25b9-3224-8bba-19ee5b4fd700|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_dihydrofolate_reductase_(DHFR)_cells pubmed:1737932|dc:contributor|Scheinberg D.A. imgt:Construct_321|obo:BFO_0000051|imgt:Segment_321_1 imgt:StudyProduct_13b1fa06-ad4b-388d-a2ec-3f587daded7f|imgt:hasClinicalIndication|imgt:Cancers_breast imgt:gDNA|protege:protege#subclassesDisjoint|true imgt:StudyProduct_b36541b6-ed7b-3042-8d5d-b27eb1b0b96a|rdf:type|obo:NCIT_C174271 imgt:mAb_854|imgt:inn_number|10825 imgt:StudyProduct_0be86c1d-c760-383a-8925-0c1bdd77caa5|imgt:isStudyProductOf|imgt:Product_9f3b70a8-1ab1-357c-82db-a284346f9860 imgt:Product_7e5d1d6d-b55c-3e83-81ba-8f67e321c93b|imgt:commun_name|CD166 PDC imgt:mAb_240|imgt:inn_name|etaracizumab imgt:Sanofi|rdfs:label|Sanofi imgt:Product_1f73dd63-2db7-39af-95ec-0844134e2f55|imgt:comercial_name|FASENRA™ imgt:StudyProduct_3288add2-7527-3c53-aea1-253f00307045|imgt:isStudyProductOf|imgt:Product_13281f2f-4bca-3019-be00-e57c1e8a801b imgt:Construct_687|imgt:hasImgtLabel|imgt:F9_(coagulation_factor_9_coagulation_factor_IX)_recombinant-ALB_(albumin_human_serum_albumin_HSA)_25-609 imgt:StudyProduct_856c5397-7756-3d89-9380-256a0d6c6b0f|rdfs:label|StudyProduct_856c5397-7756-3d89-9380-256a0d6c6b0f imgt:IgG1-kappa_1209|obo:RO_0002162|imgt:Hum _:Be0bdf5dade1d2f2e0f211d7255deded4|rdf:type|obo:NCIT_C53285 imgt:Product_705ed763-9a95-3dbd-9dae-53dd2e5131cc|imgt:hasStudyProduct|imgt:StudyProduct_fb21276c-2e68-3a34-a1e0-0370a33b37c2 imgt:StudyProduct_f9931cb1-61ae-324e-a2be-bf35bad4a04b|imgt:hasClinicalIndication|imgt:Rheumatoid_arthritis_(RA) imgt:CH4D4|skos:definition|fourth duplicated CH4 exon of IG heavy C-GENE in gDNA (found in teleostei), or fourth duplicated CH4 domain of IG heavy chain in cDNA imgt:Construct_960|imgt:isConstructOf|imgt:IgG1-kappa_960 imgt:11640|rdfs:label|11640 imgt:mAb_860|rdf:type|obo:NCIT_C166849 imgt:StudyProduct_bf5fb72f-9b99-31e6-93c6-6576fa80b026|imgt:hasExpressionSystem|imgt:_NS0_mouse_myeloma_cells imgt:Condylomata_acuminata_(anogenital_warts)|imgt:isClinicalIndicationOf|imgt:StudyProduct_94857d13-f5a5-38b1-8d94-5d1cfb81ee60 imgt:Construct_488|rdfs:label|Construct_488 imgt:SAG-DOMAIN|skos:definition|Superantigen Domain imgt:Segment_635_1|obo:BFO_0000050|imgt:Construct_635 imgt:Product_f25d68a8-4ad4-319e-aa7a-07c818be11c3|imgt:commun_name|TSR-033 _:Ba48cf146924d14a875b0813ef1415ed5|imgt:isDecidedBy|imgt:EMA imgt:Abgenix|rdf:type|obo:NCIT_C54131 imgt:FR2|skos:definition|second framework imgt:STEC_(Shiga-like_toxin-producing_Escherichia_coli_or_E._coli_serotype_O121)_infection_causing_diarrhea_and_hemolytic-uremic_syndrome_(HUS)|rdfs:label|STEC_(Shiga-like_toxin-producing_Escherichia_coli_or_E._coli_serotype_O121)_infection_causing_diarrhea_and_hemolytic-uremic_syndrome_(HUS) imgt:Product_27c6ab4e-8ce9-3ad2-92b3-945ee20d9e46|imgt:commun_name|GS-6624 imgt:StudyProduct_effa3831-1319-3a49-852d-d5eef1587a6e|imgt:hasExpressionSystem|imgt:_COS_cells_transient_expression imgt:Product_987a190a-246c-3d52-be28-47005ed09173|imgt:hasStudyProduct|imgt:StudyProduct_3de9dcf6-ee4c-31a8-b1a6-053559b14b57 imgt:Product_17f1c06a-7254-3bcb-a6b8-f928b4298284|imgt:isProducedBy|imgt:Boehringer_Ingelheim_Pharmaceuticals imgt:StudyProduct_401aaa14-9487-3e81-b224-afdfd9bfcee9|rdfs:label|StudyProduct_401aaa14-9487-3e81-b224-afdfd9bfcee9 imgt:IgG4-kappa_1168|rdfs:comment|IgG4 - kappa imgt:StudyProduct_39b3999c-d6e1-3a37-b0cb-7f6ed4baf430|imgt:application_type|Therapeutic imgt:Hemophilia_B|imgt:clinical_domain|Hematology imgt:mAb_305|rdfs:label|mAb_305 imgt:Kidney_transplantation_prevention_of_delayed_graft_function_(DGF)|imgt:clinical_domain|Immunology imgt:StudyProduct_8deb92d7-c9b3-3497-aa96-ca650a98e7d1|rdf:type|obo:NCIT_C174271 _:Bdd67d6228b9c8d9e0cf9fef2a1947846|imgt:hasStatut|imgt:approval imgt:MH2|obo:RO_0002162|imgt:Homsap imgt:Clone_366|obo:RO_0002162|imgt:Musmus imgt:Product_c4bc2033-a7b8-33b5-bffe-c1764f721429|imgt:isProductOf|imgt:mAb_996 imgt:Clone_1243|imgt:clone_name|91-37-1 imgt:KIT|imgt:isTargetOf|imgt:IgG1-kappa_1205 imgt:StudyProduct_337c97f1-fee5-35a1-a552-4d1e6dcc3d63|rdf:type|obo:NCIT_C174271 imgt:hasStatut|rdfs:label|hasStatut imgt:mAb_683|imgt:inn_number|8073 imgt:IgG1-kappa_274|imgt:hasMolecularComponent|imgt:IG imgt:ENHANCER|rdfs:label|ENHANCER imgt:FC-ALPHA-2|skos:definition|Fc comprising the CH2-CH3 domains from two H-ALPHA-2 chains imgt:IgG2a-lambda|rdf:type|imgt:SegmentLabels imgt:StudyProduct_7176d990-6d3d-3a30-b428-1afcc64e0c0f|imgt:hasClinicalIndication|imgt:Adenocarcinoma_gastric imgt:Carcinoma_head_and_neck_squamous_cell_carcinoma_(HNSCC)|imgt:isClinicalIndicationOf|imgt:StudyProduct_6c067b5c-8944-3d0a-9f1c-03d5a0b3a59f imgt:Duchenne_muscular_dystrophy_(DMD)|imgt:isClinicalIndicationOf|imgt:StudyProduct_71619e4c-0a71-3045-8eb6-0f20fac38956 imgt:IgG4-nd_3|rdf:type|imgt:MAbReceptor imgt:mAb_301|imgt:inn_number|9128 obo:NCIT_C152350|rdf:type|owl:Class imgt:StudyProduct_6fad6acb-c3ec-3c46-a459-b4675e583d8c|imgt:hasClinicalPhase|imgt:Phase_II imgt:Segment_592_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Construct_562|obo:BFO_0000051|imgt:Segment_562_1 obo:NCIT_C102566|rdfs:subClassOf|obo:NCIT_C1909 imgt:Product_ed8d0555-7f62-3cdb-9892-679238204c82|imgt:hasStudyProduct|imgt:StudyProduct_06e79333-0df6-3903-975e-83ef7a568ef7 imgt:mAb_504|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=504 imgt:Severe_acute_respiratory_syndrome_coronavirus_(SARS-CoV)|imgt:isTargetOf|imgt:(VH-CH2-CH3)2_S_1220 imgt:IgG1-kappa_1175|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:Oculis_SA|rdfs:label|Oculis SA imgt:mAb_1264|imgt:inn_proposed_list|126 (2022) imgt:Product_38366130-a996-3336-8943-ab4efcfb1fbc|rdf:type|obo:NCIT_C51980 imgt:StudyProduct_4809e2f0-a270-39eb-a913-7c592fd65ccc|imgt:isStudyProductOf|imgt:Product_480f91be-f048-34a5-9224-9a68a0291dd8 imgt:Product_6b5c5fd9-8960-35c5-8529-7c4bc6114ae0|imgt:isProductOf|imgt:mAb_873 imgt:Chronic_focal_encephalitis_(CFE)|imgt:isClinicalIndicationOf|imgt:StudyProduct_73ab36bd-5102-3aa2-b945-5975cdc7247f imgt:Hereditary_Angioedema (HAE)|imgt:isClinicalIndicationOf|imgt:StudyProduct_ec1798ac-2199-3919-ad0e-c13ffdccdd14 imgt:AstraZeneca|imgt:produces|imgt:Product_65ff39db-abc8-3fea-a44b-33c9a2a782e2 imgt:Type_2_diabetes_(T2_DM)|imgt:isClinicalIndicationOf|imgt:StudyProduct_b07cddb6-dde6-357b-8183-6c0a9d745fc5 imgt:F(AB')2-GAMMA-2_KAPPA|rdf:type|imgt:StructureLabels imgt:StudyProduct_c93d5477-8120-313a-86b7-5b1befbe0ef3|imgt:isStudyProductOf|imgt:Product_e52c7cd4-ad8e-39a4-bf10-d325883a23cd imgt:StudyProduct_25d572e2-3633-3829-b477-3a66deb30420|rdfs:label|StudyProduct_25d572e2-3633-3829-b477-3a66deb30420 imgt:mAb_619|rdfs:label|mAb_619 imgt:StudyProduct_c44937d5-47d6-3303-a118-7b724d88dc14|imgt:isStudyProductOf|imgt:Product_5830c2e2-44a5-3e14-982c-9fb387cb368a imgt:StudyProduct_ec304d9a-2c0c-33e1-b37b-df7ea6c79222|rdf:type|obo:NCIT_C174271 imgt:Incyte_Corporation|imgt:produces|imgt:Product_375c2e4e-3527-3271-b018-448b9ee8aba7 imgt:Segment_700_2|imgt:hasImgtLabel|imgt:XTEN imgt:IgG1-kappa_381|imgt:isMabReceptorOf|imgt:mAb_381 imgt:Product_5de6a99e-dedd-3ea1-be46-1a994fd0890e|imgt:commun_name|MORAb-028 imgt:half-G1-kappa_scFv-HEAVY-LAMBDA-h-CH2-CH3_921|imgt:isMabReceptorOf|imgt:mAb_921 imgt:StudyProduct_a186afa2-4718-3a82-81f9-640ec7c1cc30|rdf:type|obo:NCIT_C174271 imgt:Segment_1017_1|rdf:type|imgt:Segment imgt:Product_94679014-1264-3d40-af82-d997b52a4481|imgt:isProductOf|imgt:mAb_703 imgt:Segment_639_1|rdf:type|imgt:Segment imgt:mAb_879|imgt:hasProduct|imgt:Product_93b7132b-5be4-3248-9d55-bb48290a5de1 imgt:StudyProduct_6c878ada-1306-3956-b6b2-ee886b0c2e29|imgt:hasClinicalPhase|imgt:Phase_II imgt:Gout|rdfs:label|Gout imgt:Clone_165|imgt:isOriginCloneOf|imgt:mAb_165 imgt:FN2-2|skos:definition|Fibronectin II imgt:Product_75887499-8f5b-30c3-93da-094e1967a72b|rdf:type|obo:NCIT_C51980 imgt:Triumvira_Immunologics|rdf:type|obo:NCIT_C54131 imgt:Cancers|imgt:isClinicalIndicationOf|imgt:StudyProduct_11ac2320-3ae3-3557-ae97-a40a10f1798b imgt:StudyProduct_163e4859-4df9-3329-97e3-dc1e168bb762|imgt:hasClinicalIndication|imgt:Solid_tumors imgt:11038|rdf:type|obo:NCIT_C25402 imgt:Product_f5a5b548-f6f0-301d-a830-84a84abe6bed|rdfs:label|Product_f5a5b548-f6f0-301d-a830-84a84abe6bed imgt:mAb_327|imgt:hasMabReceptor|imgt:IgG1-kappa_327 imgt:Construct_1191|obo:BFO_0000051|imgt:Segment_1191_1 imgt:Boehringer_Ingelheim_Pharmaceuticals|imgt:produces|imgt:Product_b8b97efb-86a2-33a6-b3a8-01f88c1daea3 imgt:Ebola_virus_infection|imgt:isClinicalIndicationOf|imgt:StudyProduct_7a96fb44-bee0-36fc-89c4-dfaffc85aa16 imgt:IgG1-kappa_463|obo:RO_0002162|imgt:Homsap imgt:StudyProduct_3d3b1b00-4296-3c01-9e34-6a5b725dbe90|imgt:isStudyProductOf|imgt:Product_8deb0f9b-5b13-309d-a50b-a0f5692743cc imgt:StudyProduct_edecf533-0f48-3169-b1b6-54b81c7e8009|rdf:type|obo:NCIT_C174271 imgt:Product_9152abee-e3e8-3240-868b-21aaee47b104|imgt:commun_name|IMC-20D7S imgt:IgG2-kappa_363|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG2-kappa.png imgt:StudyProduct_a44c4da7-3f39-38c1-8aef-8bfc59cb734e|imgt:hasClinicalPhase|imgt:Phase_II imgt:Construct_397|obo:BFO_0000051|imgt:Segment_397_2 imgt:mAb_211|imgt:imgt_note| Immunotoxin: An immunotoxin is an antibody linked (fused or conjugated) to a toxin. December 1994 Discontinued by Immunogen. 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imgt:Solid_tumors|imgt:isClinicalIndicationOf|imgt:StudyProduct_5bdaac6d-ba9c-3f18-bdc9-82c9ce089909 imgt:StudyProduct_a3800fc5-233c-3edd-bd1c-f42059b81c6a|imgt:isStudyProductOf|imgt:Product_485d748c-9ee2-352a-aaf4-3297a649c274 imgt:Construct_232|rdf:type|imgt:Construct imgt:(DJ)-J-C-CLUSTER|skos:definition|genomic DNA of an IG or TR locus, in rearranged configuration, including at least one D-J-GENE, one J-GENE and one C-GENE imgt:Product_87b4f91f-0f72-3325-99d8-da600f41c074|imgt:isProductOf|imgt:mAb_646 imgt:Product_5a522bda-223b-3b4e-80fb-796b1b9ea3b5|rdfs:label|Product_5a522bda-223b-3b4e-80fb-796b1b9ea3b5 _:B97c3ef969c6b306c07800b734dde316b|imgt:isDecidedBy|imgt:FDA obo:NCIT_C1647|rdfs:subClassOf|obo:NCIT_C1909 imgt:IgG4-kappa_970|imgt:hasConstruct|imgt:Construct_970 imgt:StudyProduct_c0ffec3c-ac52-3c49-9b5e-457434b1b4a4|imgt:development_technology| Alternative to antigen receptors domain scaffold ANK, ankyrin repeats (DARPin®) imgt:StudyProduct_39c8413c-f2f0-387f-9491-e0db23b778a5|imgt:application_type|Therapeutic imgt:PEPTIDE-PEPTIDE-CARRIER_BIG_397|obo:RO_0002162|imgt:Homsap _:B28e143124171a2016dec4e580e494853|dc:date|2018-04-16 imgt:Vir_Biotechnology|rdfs:comment|San Francisco , USA imgt:11402|rdf:type|obo:NCIT_C25402 imgt:StudyProduct_185b82b9-df56-3ad2-94f8-31f51bdf8e85|imgt:hasClinicalPhase|imgt:Phase_M imgt:Fab-G2b-kappa_133|rdfs:label|Fab-G2b-kappa_133 imgt:PDCD1|imgt:isTargetOf|imgt:IgG4-kappa_846 _:Bc811fa3cbe901692ea6d2592d64e96cc|imgt:isDecidedBy|imgt:FDA imgt:V-gene|rdf:type|imgt:Molecule_EntityType imgt:IgG4-kappa_752|imgt:isMabReceptorOf|imgt:mAb_752 imgt:StudyProduct_a3aa9a89-b162-305d-b9cf-f56e5aee9631|imgt:hasDecision|_:Beed3b5cdaa2425c8b20c23d28a4f5d43 imgt:Hematologic_malignancies|imgt:isClinicalIndicationOf|imgt:StudyProduct_7640506d-2ee9-31ad-b125-b376dafa5452 imgt:IgG1-kappa-S239C_2cys-drug_904|rdfs:comment|IgG1 - kappa - S239C_2cys - drug imgt:Construct_931|obo:BFO_0000051|imgt:Segment_931_1 imgt:11111|rdf:type|obo:NCIT_C25402 imgt:StudyProduct_6cda6c53-9c78-3193-8e03-e70cf6022635|imgt:hasDecision|_:Be3c3f917d51b84f91a81e154fa5311e6 imgt:9083|rdf:type|obo:NCIT_C25402 imgt:Product_db3d4ac6-821a-3423-ba1d-61b8ad6cf363|imgt:isProductOf|imgt:mAb_605 imgt:mAb_760|imgt:inn_recommended_list|79 (2018) imgt:Product_e9ad6c68-27ee-31c2-86ce-72d047684265|rdfs:label|Product_e9ad6c68-27ee-31c2-86ce-72d047684265 imgt:B-cell_malignancies|imgt:isClinicalIndicationOf|imgt:StudyProduct_0f8fede9-ec3e-312e-b988-8fd26a9c1fd3 imgt:IgG4-kappa-protein_982|rdf:type|imgt:MAbReceptor imgt:Product_c35429a8-2c73-3c01-bfd2-200427b3e81f|imgt:commun_name|131-l-8H9 imgt:mAb_617|rdf:type|obo:NCIT_C1909 _:Bee5c62a7b3aad55cb832b3bb94b72646|dc:date|2004-07-16 imgt:CEACAM5|imgt:isTargetOf|imgt:MAbReceptor_50 imgt:StudyProduct_0f7eb5d2-25f4-3ec3-903d-96073744e63d|imgt:isStudyProductOf|imgt:Product_9dffd059-b722-3974-93df-d78b1bdd84a7 imgt:11435|imgt:isImgtStructureEntryOf|imgt:mAb_1076 imgt:mAb_654|rdf:type|imgt:INN imgt:StudyProduct_6cda6c53-9c78-3193-8e03-e70cf6022635|rdf:type|obo:NCIT_C174271 imgt:IgG1-kappa_724|imgt:hasConstruct|imgt:Construct_724 imgt:mAb_885|imgt:inn_name|efgivanermin alfa imgt:Product_b8b97efb-86a2-33a6-b3a8-01f88c1daea3|imgt:isProducedBy|imgt:Boehringer_Ingelheim_Pharmaceuticals imgt:Product_1b66cd8f-973f-324a-9af1-29e3f46d766e|imgt:isProducedBy|imgt:Mycenax_Biotech_Inc imgt:mAb_512|imgt:inn_number|10062 imgt:Segment_890_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_0854d775-99e9-3c84-9281-f5daab24b6dc imgt:Construct_247|rdfs:label|Construct_247 imgt:StudyProduct_4b3ccea3-961f-3102-9e9c-20f015542dfe|imgt:hasClinicalPhase|imgt:Phase_M imgt:F(ab’)2-Gamma-3_Kappa|imgt:isDefinedBy|imgt:IG-Light-Kappa-IGKC imgt:StudyProduct_1c930957-c1fa-3c37-9b43-b9b974ede1ac|imgt:hasClinicalIndication|imgt:Cancers_gastric imgt:Product_e055a0d3-71ff-3d4e-ad35-050d316b88bd|imgt:comercial_name|ACTIMMUNE® imgt:Construct_889|imgt:isConstructOf|imgt:PROTEIN_1DOMAIN-PEG_889 imgt:Product_eb402421-c224-38d4-94cb-61de3b050a04|imgt:isProductOf|imgt:mAb_122 imgt:StudyProduct_a6cccb99-f53a-3f9d-a88a-78cddbbb9f74|imgt:isStudyProductOf|imgt:Product_d61df4aa-b1c6-3a08-a7ca-b17b107e0a96 imgt:Genentech_Inc|imgt:produces|imgt:Product_32e24328-6c7b-375a-89c3-aca2f2e5265b imgt:IgG1-G2-kappa|rdf:type|imgt:SegmentLabels imgt:TR-GAMMA-4|imgt:describes|imgt:TR-Gamma-4-TRGC4 imgt:mAb_1214|rdf:type|obo:NCIT_C175228 imgt:4GW1|rdf:type|obo:NCIT_C25402 imgt:mAb_79|imgt:hasBibliographicReference|pubmed:9779762 imgt:isDecisionOf|rdfs:range|obo:NCIT_C174271 imgt:IgG1-kappa_544|http://semanticscience.org/resource/SIO_000291|imgt:IL1A imgt:StudyProduct_474aa71c-98e8-33be-a008-be448cf8004d|rdf:type|obo:NCIT_C174271 imgt:HLA-DR10|skos:definition|HLA-DR10 (DRB1*1001) imgt:Cancers_colorectal_(CRC)_metastatic|imgt:isClinicalIndicationOf|imgt:StudyProduct_aff38747-7ed5-3b5c-a493-e2efbccb1aa7 imgt:IgG1-kappa_1126|rdfs:label|IgG1-kappa_1126 imgt:Segment_1010_1|imgt:hasImgtLabel|imgt:IgG4-kappa imgt:mAb_30|rdf:type|obo:NCIT_C1909 imgt:StudyProduct_ea0488b6-c294-342d-a0a3-e55774de78f0|imgt:hasDecision|_:Bee2ffe8d818afd6889abb95956e3d931 imgt:9153|imgt:isImgtStructureEntryOf|imgt:mAb_162 imgt:Product_fe170d32-2e79-37f8-b44b-a495e80a927a|imgt:hasStudyProduct|imgt:StudyProduct_4778a46d-c73d-3a03-9a1f-5b7d0dabf9c3 imgt:StudyProduct_988f16a7-b509-3d22-868d-d5da13250685|rdfs:label|StudyProduct_988f16a7-b509-3d22-868d-d5da13250685 imgt:mAb_180|imgt:hasProduct|imgt:Product_8a6a655e-c029-3db0-abba-ab5a2dc29089 imgt:Solid_tumors|imgt:isClinicalIndicationOf|imgt:StudyProduct_a8ea883b-ad98-3d73-b97d-2073a9f79ed1 imgt:Product_2715c586-cf44-3ed8-a87b-0d76d5b9bd0c|rdf:type|obo:NCIT_C51980 imgt:H-GAMMA-2A|rdfs:label|H-GAMMA-2A imgt:INN|rdfs:label|INN obo:NCIT_C71694|rdfs:subClassOf|obo:NCIT_C1909 imgt:F9_(coagulation_factor_9_coagulation_factor_IX)_recombinant_(variant_011773)_glycosylated_(glycoform_alfa)|rdfs:label|F9 (coagulation factor 9, coagulation factor IX) recombinant (variant_011773) glycosylated (glycoform alfa) imgt:Construct_621|imgt:isConstructOf|imgt:IgG1-kappa_621 imgt:scFv-kappa-heavy-scFv-kappa-heavy-CD4(CO-TM-CY)_1232|imgt:hasMolecularComponent|imgt:IG imgt:Clone_58|obo:RO_0002162|imgt:Musmus imgt:Janssen_Biotech_Inc|imgt:produces|imgt:Product_01b5f204-410d-3c17-b3ed-fa08cfd577af imgt:Clone_793|imgt:isOriginCloneOf|imgt:mAb_793 imgt:Construct_665|rdfs:label|Construct_665 imgt:Construct_911|rdf:type|imgt:Construct imgt:Construct_701|obo:BFO_0000051|imgt:Segment_701_1 imgt:StudyProduct_33f0c871-917c-343e-a485-18b51d0b2bb4|imgt:hasClinicalIndication|imgt:Melanoma_metastatic imgt:Product_c4b5a4f9-01ee-3823-90ef-f047993fe32e|rdf:type|obo:NCIT_C51980 imgt:Sanofi|imgt:produces|imgt:Product_0e71815e-bc5c-3088-87f0-5fb9ca2d7a89 imgt:Clone_1244|rdfs:label|Clone_1244 imgt:Product_d2ec8f84-8e6c-3e77-a1a1-3801089fac58|imgt:hasStudyProduct|imgt:StudyProduct_f4bdbbd9-8aab-3285-8551-ea24893f5ea6 imgt:Construct_591|rdf:type|imgt:Construct imgt:StudyProduct_1139de5f-d2df-3035-acd7-dd41b73b2066|imgt:hasDecision|_:B0b527a90fab17cbdfe67f8a445c6d57b imgt:Lonza_Biologics|imgt:produces|imgt:Product_48a3e4f4-bc9a-3246-8b3d-6b922a64162b imgt:StudyProduct_280d1c05-63f1-3caa-830e-5c037b28d442|imgt:hasClinicalPhase|imgt:Phase_II imgt:grasustek|rdfs:comment| GRASUSTEK developed by Amgen (Thousand Oaks CA USA) approved in EU by EC on April 26 2019 EMEA/H/C/004556 Same clinical indications as NEULASTA®. imgt:Construct_1102|rdfs:label|Construct_1102 imgt:mAb_75|rdfs:label|mAb_75 imgt:StudyProduct_1ab6f629-409a-3845-af58-ed63289782ab|rdf:type|obo:NCIT_C174271 imgt:Segment_36_1|obo:BFO_0000050|imgt:Construct_36 imgt:Pfizer|imgt:produces|imgt:Product_9a37b649-0228-35b8-a6ed-2d5443acebbc imgt:StudyProduct_910fdcc2-e291-3f1f-9bc5-5013d7e52310|rdf:type|obo:NCIT_C174271 imgt:FUSION-TNFRSF1A-GAMMA-1|rdf:type|imgt:ChainLabels imgt:Product_2cb0cab5-75d3-3ff4-8cf5-4895a2fa5226|imgt:isProductOf|imgt:mAb_169 _:B63c7d069b724fa5444696b20cdac46f4|dc:date|2013-09-12 imgt:Product_45b55869-eb86-366c-8a1f-6cb1704d14b2|imgt:hasStudyProduct|imgt:StudyProduct_49f1d43e-264d-3e76-badc-3188f448e9a7 imgt:IgG2-kappa_196|imgt:hasMolecularComponent|imgt:IG imgt:Product_856b0b55-813b-3ad1-b994-aaca500e9da0|imgt:commun_name|ACA125 imgt:Segment_285_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:IgG1-kappa-2cys-drug_775|imgt:isMabReceptorOf|imgt:mAb_775 imgt:mAb_428|imgt:hasMabReceptor|imgt:IgG1-kappa_428 imgt:ACVR2A|skos:definition|ActRIIA receptor imgt:StudyProduct_a0d85c1a-e8a8-32c7-a7d3-b4736de24f27|imgt:hasClinicalIndication|imgt:Acute_myocardial_infarction imgt:StudyProduct_a69d95a2-61b0-3b7f-90b8-ae7a1a95ba77|rdfs:label|StudyProduct_a69d95a2-61b0-3b7f-90b8-ae7a1a95ba77 imgt:Construct_103|obo:BFO_0000051|imgt:Segment_103_1 _:Bc1f8e9b42142e46db86471c708845dea|rdf:type|obo:NCIT_C53285 imgt:Fab-G1-kappa_901|imgt:hasMolecularComponent|imgt:IG imgt:StudyProduct_0a9ebf98-2862-3f47-984d-b0a63bc0d12f|rdf:type|obo:NCIT_C174271 imgt:Construct_264|obo:BFO_0000051|imgt:Segment_264_2 imgt:Product_e38af4fc-2c80-31d3-819d-531f2c0ed7a1|imgt:hasStudyProduct|imgt:StudyProduct_509bb226-401e-3d90-9013-44d26182ffb5 imgt:StudyProduct_0be86c1d-c760-383a-8925-0c1bdd77caa5|imgt:application_type|Therapeutic imgt:Segment_941_1|imgt:has_rank|1 imgt:IgG2-kappa_332|rdfs:comment|IgG2 - kappa imgt:IgG1-kappa_MM_663|imgt:hasMolecularComponent|imgt:IG imgt:10506|rdf:type|obo:NCIT_C25402 imgt:StudyProduct_266c9a8b-b30f-31e0-8c88-5a81d6029d4d|imgt:isStudyProductOf|imgt:Product_d38d61b1-643a-33d9-9785-f4b0aad161ed imgt:Product_b867f21e-ad50-386a-8346-0ac25d92425d|rdf:type|obo:NCIT_C51980 imgt:StudyProduct_c175e745-f820-3535-a583-cecc65a29f5f|imgt:hasClinicalIndication|imgt:Waldenstrom's_macroglobulinemia imgt:mAb_578|imgt:hasProduct|imgt:Product_8f6778ef-a64d-388c-88a1-0e1430c26f55 imgt:FC-%5BPEPTIDE-PEPTIDE%5D2_408|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/FC-[PEPTIDE-PEPTIDE]2.png imgt:StudyProduct_975e1353-8fe5-30e5-bb01-d75eb6760ec9|imgt:development_technology| Alternative to antigen receptors domain scaffold THB, three helical bundle (Affibody®) imgt:Segment_1284_1|imgt:has_rank|1 imgt:StudyProduct_3ff2cb83-f81b-3da6-9128-579440ac058a|imgt:isStudyProductOf|imgt:Product_571363e1-b863-3e4b-852a-36fb1cc4957c imgt:Construct_581|imgt:hasImgtLabel|imgt:%5BIGHG4_Fc_(Fragment_constant)-TRAF2_(TNF_receptor_associated_factor_2_TRAP3_RNF117)-TNFSF4_(tumor_necrosis_factor_(TNF)_superfamily_member_4_OX40_ligand_OX-40L_TAX_transcriptionally-activated_glycoprotein_1_TXGP1_gp34_CD252)%5D-trimer imgt:StudyProduct_96603d21-ce18-3f87-9d06-4acc1b685b08|imgt:hasClinicalIndication|imgt:Crohn's_disease_(CD) imgt:Product_d34f1ebd-acfa-3151-b703-7247bec7bb83|imgt:isProductOf|imgt:mAb_367 imgt:IG-GAMMA-1_LAMBDA|imgt:describes|imgt:IgG1_Lambda _:B2e5cd6a94d8e0eb99c3f88b4fa0e7266|imgt:isDecidedBy|imgt:FDA imgt:Age-related_macular_degeneration_(AMD)_neovascular_(wet)|imgt:isClinicalIndicationOf|imgt:StudyProduct_4d1292cd-3039-3fa6-b39f-3bfb654a58a7 imgt:mAb_180|imgt:hasImgtStructureEntry|imgt:6JC2 imgt:StudyProduct_b25cd041-82a5-3088-b657-c14bfb556311|imgt:application_type|Diagnostic imgt:atc_link|rdf:type|owl:AnnotationProperty imgt:Construct_498|obo:BFO_0000051|imgt:Segment_498_1 imgt:mAb_316|imgt:inn_recommended_list|35 (1995) imgt:StudyProduct_d8318d00-b414-39be-b333-9d2efbca41d1|rdfs:label|StudyProduct_d8318d00-b414-39be-b333-9d2efbca41d1 imgt:StudyProduct_6cc7eb61-cc26-3a7e-88f5-9c4a2d7d3d53|imgt:isStudyProductOf|imgt:Product_f3abdd35-f591-3d8f-9db6-8a118a10c572 imgt:mAb_1057|rdf:type|imgt:INN imgt:Cancers_colorectal_(CRC)_metastatic|imgt:isClinicalIndicationOf|imgt:StudyProduct_33ab53fc-a53d-3a35-abcd-10985da021b7 imgt:Segment_974_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:StudyProduct_3713f3fb-8ee7-3050-ab44-1f50b9aa2bb6|imgt:hasClinicalPhase|imgt:Phase_I imgt:Product_811fe504-a8bf-3b42-ac45-867ba561364b|rdfs:label|Product_811fe504-a8bf-3b42-ac45-867ba561364b imgt:mAb_723|rdf:type|obo:NCIT_C119740 imgt:VH-V-LAMBDA|rdfs:label|VH-V-LAMBDA imgt:Segment_1247_1|rdf:type|imgt:Segment imgt:mAb_44|imgt:inn_recommended_list|45 (2001) imgt:CD274|imgt:isTargetOf|imgt:VH-VH%27-h-CH2-CH3_1127 imgt:(VDJ)-C-CLUSTER|rdf:type|imgt:ComposedClusterLabel imgt:mAb_1036|imgt:hasImgtStructureEntry|imgt:11344 imgt:Product_2a04404b-386e-38b5-b7dc-852b6a25d83c|rdf:type|obo:NCIT_C51980 imgt:Clone_1217|rdfs:label|Clone_1217 imgt:Multiple_myeloma_(MM)|imgt:isClinicalIndicationOf|imgt:StudyProduct_136b19c1-f828-3e0c-ae4b-7485ce8c4389 imgt:Product_80df9e94-ee60-3921-a952-9cd7b81e01e6|imgt:isProductOf|imgt:mAb_994 imgt:StudyProduct_6467b730-1f75-3463-aefd-b86721502ab9|rdf:type|obo:NCIT_C174271 imgt:MADCAM1|rdf:type|imgt:ChainLabels imgt:mAb_65|imgt:inn_name|naptumomab estafenatox imgt:StudyProduct_968fbf49-5957-3688-82d1-663e77cd7d5d|imgt:hasClinicalIndication|imgt:Cachexia imgt:flixabi®|imgt:isBiosimilarOf|imgt:mAb_156 imgt:7906|imgt:isImgtStructureEntryOf|imgt:mAb_151 imgt:Product_aaf2e2c9-1c88-3eed-ab99-9dbe7332094a|imgt:commun_name|NI-1401 imgt:IgG4-kappa_859|obo:RO_0002162|imgt:Homsap imgt:Lipodystrophy|rdf:type|obo:NCIT_C185637 imgt:mAb_408|imgt:inn_proposed_list|106 (2011) imgt:IgG1-kappa_1275|imgt:hasMolecularComponent|imgt:IG imgt:StudyProduct_b967370f-7324-3cbd-ae31-63047f764182|imgt:hasClinicalIndication|imgt:Congenital_F_VII_deficiency imgt:Product_ad7c3645-09ab-3543-a583-4b655423ca16|rdf:type|obo:NCIT_C51980 imgt:IgG4-kappa_259|obo:RO_0002162|imgt:Hum imgt:5V-LIKE|skos:definition|Chain or receptor comprising five V-LIKE domains imgt:StudyProduct_3dd848dc-265a-30d8-ba58-470497ee2ecb|imgt:development_technology| Cambridge Antibody Technology (CAT) human antibody phage display library imgt:Product_f67bf612-c97e-3f7e-9be7-c3022bf8d1b1|imgt:isProductOf|imgt:mAb_486 imgt:describes|rdfs:comment|describes imgt:StudyProduct_2314246e-4d62-3512-9c45-8393eff5d5e5|imgt:hasExpressionSystem|imgt:_CHO-S_(Chinese_Hamster_Ovary)_cells_suspension_culture imgt:StudyProduct_1158859d-da28-3dbe-974c-69b321460d2c|imgt:hasClinicalPhase|imgt:Phase_M _:B2ce12e99eb7ae1cc6af52e9fd11aed03|rdf:type|obo:NCIT_C53285 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imgt:mAb_885|imgt:inn_recommended_list|82 (2019) imgt:Construct_1083|imgt:hasImgtLabel|imgt:half-IG_G1-kappa/(scFv-kappa-heavy)-h-CH2-CH3 imgt:Product_cc23c10b-ddcd-3dab-8705-97745fb10a52|imgt:commun_name|IBI-302 imgt:Segment_505_1|rdfs:label|Segment_505_1 imgt:Segment_1294_1|imgt:segment_detail|fragment (1-305, containing the\r immunoglobulin-like C2-type domains 1, 2 and 3) imgt:VH-VH%27-H-Gamma4-VL-VL%27-C-kappa_794|obo:RO_0002162|imgt:Hum imgt:StudyProduct_a78a0ef6-c705-3475-860d-516b5d771dea|imgt:development_technology| TRuC-T Cell Therapy imgt:Product_eb402421-c224-38d4-94cb-61de3b050a04|imgt:hasStudyProduct|imgt:StudyProduct_49630eff-3c50-36c8-b562-6cd7a15dde73 imgt:Product_d48dfd80-b563-3b2c-bc14-3f6855226bd6|rdf:type|obo:NCIT_C51980 imgt:IgG2-lambda_448|rdfs:label|IgG2-lambda_448 imgt:IgG1-kappa-4lys-drug_490|imgt:hasMolecularComponent|imgt:IG imgt:CH2D|skos:definition|duplicated CH2 exon of IG heavy C-GENE in gDNA (found in teleostei), or duplicated CH2 domain of IG heavy chain in cDNA _:B54ba76f45c209d42e8ee61bc84aaa3b1|imgt:isDecisionOf|imgt:StudyProduct_5f24239e-1e10-32d1-8b60-8abd532e4dd8 imgt:Asthma|imgt:isClinicalIndicationOf|imgt:StudyProduct_eba550c7-d4c5-3404-9bd1-41a9355ec09c imgt:mAb_594|rdf:type|obo:NCIT_C152505 imgt:StudyProduct_0073239e-4b51-34b4-b68a-9247058363c5|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:Hepatocellular_carcinoma_(HCC)|imgt:isClinicalIndicationOf|imgt:StudyProduct_3df7fc50-e08e-3bfa-8850-a020eaf0a4fd imgt:Product_2b19c2f5-d596-3bcf-8b1b-86730cfcfc4b|imgt:isProducedBy|imgt:Eli_Lilly _:B02ce6bcbe50f8087e67877a80b0c4ef8|imgt:hasDesignation|imgt:Orphan_drug imgt:VH-VH%27_523|imgt:hasConstruct|imgt:Construct_523 imgt:Eli_Lilly|imgt:produces|imgt:Product_4b923003-44a0-305e-869a-41e26bddedbb imgt:IgG1-kappa_1018|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:FPIA_%5BPROTEIN_PROTEIN%5D2-FC-%5BPROTEIN%5D2_1228|http://semanticscience.org/resource/SIO_000291|imgt:C3 imgt:Construct_779|rdf:type|imgt:Construct imgt:Segment_58_1|rdf:type|imgt:Segment imgt:IgG1-kappa_407|rdfs:comment|IgG1 - kappa imgt:StudyProduct_19d23e6a-0f31-3650-a817-d2389d919f74|imgt:hasClinicalIndication|imgt:Cancers_colorectal_(CRC)_metastatic imgt:StudyProduct_11d7cde9-1c65-30b2-ab31-d7861e5ed7cc|rdfs:label|StudyProduct_11d7cde9-1c65-30b2-ab31-d7861e5ed7cc _:B5c9a44e3974168f59d373ba03bb9b9dc|imgt:isDecisionOf|imgt:StudyProduct_dece01d9-67ae-3cd7-8c6c-b0a053d1f3e8 imgt:StudyProduct_c8332a03-e7ae-3c3b-909b-b7aeff4285b8|imgt:application_type|Therapeutic imgt:mAb_176|imgt:hasImgtStructureEntry|imgt:8887 imgt:mAb_172|imgt:hasProduct|imgt:Product_892634ba-c82f-36f9-9106-1537e1c79b28 imgt:Product_a77a82e8-1666-32c6-9125-86cdca4d3f25|rdf:type|obo:NCIT_C51980 imgt:Clone_36|obo:RO_0002162|imgt:Musmus imgt:mAb_757|imgt:inn_proposed_list|117 (2017) imgt:Product_b9d6b5b2-5634-3387-bfc9-34637876dd2c|imgt:hasStudyProduct|imgt:StudyProduct_f5388cb8-36d9-38bd-8a0d-06112db2d0b9 imgt:mAb_259|imgt:inn_name|inotuzumab ozogamicin imgt:PEPTIDE_706|rdfs:label|PEPTIDE_706 imgt:Segment_1151_1|obo:BFO_0000050|imgt:Construct_1151 imgt:Construct_1254|rdf:type|imgt:Construct imgt:mAb_941|imgt:inn_name|avizakimab imgt:3'D-NONAMER|owl:sameAs|obo:SO_0000494 imgt:Segment_872_1|imgt:has_rank|1 imgt:StudyProduct_7e5efcc1-687c-365c-a2e5-3aca55e7574e|imgt:hasExpressionSystem|imgt:_CHO_DG44_(Chinese_Hamster_Ovary)_cells obo:NCIT_C53285|skos:definition|A position, opinion, or judgment reached on an issue under consideration. imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_6974cbb5-2147-37d3-b512-1d3f6aa12a09 imgt:Construct_159|imgt:hasImgtLabel|imgt:IgG2a-nd imgt:_Corynebacterium_glutamicum|imgt:isExpressionSystemOf|imgt:StudyProduct_18a6f88b-127f-31d2-8cc4-dba82ee281b8 imgt:mAb_392|imgt:inn_recommended_list|53 (2005) imgt:mAb_335|rdfs:label|mAb_335 imgt:Segment_1227_2|rdfs:label|Segment_1227_2 imgt:mAb_320|imgt:inn_number|6345 imgt:IG-GAMMA-1_LAMBDA-2|rdf:type|imgt:IGCompleteReceptorLabel imgt:StudyProduct_b1c4136c-d42f-3286-9835-8b24f416647c|imgt:hasClinicalIndication|imgt:Inflammatory_conditions imgt:RTN4|obo:RO_0002162|imgt:Homsap imgt:IgG4-kappa_1236|imgt:isMabReceptorOf|imgt:mAb_1236 imgt:mAb_63|rdf:type|obo:NCIT_C1909 imgt:Product_02fe4a68-d0bb-3cbf-b94d-94fcfd5ced22|imgt:commun_name|MSB-0010841 imgt:Fab-G1-kappa_421|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/Fab-G1-kappa.png imgt:Product_0477f890-c9d2-3f6e-a320-339542f67ab5|rdfs:label|Product_0477f890-c9d2-3f6e-a320-339542f67ab5 imgt:StudyProduct_779e8d3c-771b-3db2-b266-f39270e7d9a7|imgt:hasClinicalPhase|imgt:Phase_IV imgt:StudyProduct_0d0b843e-ae7e-3ec1-8787-5451392da30d|rdf:type|obo:NCIT_C174271 imgt:mAb_448|imgt:clinical_trials|93 studies found, 38 recruiting imgt:Product_e0d4f8c9-7b9c-3c41-b174-0bc1765d8966|imgt:isProductOf|imgt:mAb_1234 imgt:%5BACE2_(angiotensin_converting_enzyme_2_angiotensin_I_converting_enzyme_(peptidyl-dipeptidase_A)_2_ACEH)_fragment_(1-715)%5D2-IGHG4_Fc_(Fragment_constant)|imgt:construction_detail|Fusion - [ACE2 (angiotensin converting enzyme 2, angiotensin I converting enzyme (peptidyl-dipeptidase A) 2, ACEH) fragment (1-715)]2 - IGHG4 Fc (Fragment constant) imgt:StudyProduct_946f07c9-d4f0-31e7-93ab-c6d674e08dd4|imgt:application_type|Therapeutic pubmed:3393390|dc:contributor|Herin P imgt:mAb_1266|imgt:hasOriginClone|imgt:Clone_1266 imgt:Product_27c6ab4e-8ce9-3ad2-92b3-945ee20d9e46|imgt:hasStudyProduct|imgt:StudyProduct_55e7541c-3eab-3d0c-9193-6cda10fdcba2 imgt:mAb_626|rdf:type|obo:NCIT_C1909 imgt:StudyProduct_1d4aa306-6821-3719-8f13-e1bab47134c8|rdf:type|obo:NCIT_C174271 imgt:Product_e307cb3e-aef8-35ec-8bfb-bee27d4d2030|imgt:isProducedBy|imgt:Kyowa_Hakko_Kirin imgt:StudyProduct_3d3b1b00-4296-3c01-9e34-6a5b725dbe90|imgt:hasClinicalPhase|imgt:Phase_III imgt:Construct_312|rdf:type|imgt:Construct imgt:StudyProduct_53587d06-8dde-35d5-8cd7-46ca2236a4ff|imgt:hasClinicalPhase|imgt:Phase_I imgt:StudyProduct_aa504c9b-ee8c-379e-bf9d-7b3a22c05ac9|imgt:hasClinicalPhase|imgt:Phase_I imgt:Severe_acute_respiratory_syndrome_coronavirus_2_(SARS-CoV-2)|imgt:isTargetOf|imgt:IgG1-kappa_1104 imgt:Segment_129_1|rdfs:label|Segment_129_1 imgt:mAb_1103|imgt:hasProduct|imgt:Product_d9fe60c8-e3ba-38f6-9a6b-356dcf80a1bc imgt:mAb_970|imgt:inn_recommended_list|83 (2020) imgt:Segment_1052_1|imgt:segment_detail|isoform A imgt:Segment_865_1|imgt:hasImgtLabel|imgt:scFv-heavy-lambda imgt:Pseudomonas_aeruginosa_infections|imgt:isClinicalIndicationOf|imgt:StudyProduct_f5c1627a-5729-3447-8e2f-af98343675cf imgt:Segment_540_1|obo:BFO_0000050|imgt:Construct_540 imgt:mAb_604|imgt:hasProduct|imgt:Product_4a5c4039-6661-3fa4-a1ee-9a7e6ff795b2 imgt:IL22RA1|rdf:type|obo:NCIT_C25702 imgt:Product_64d31d25-899a-3941-a5d0-bc3b3c0b468b|imgt:isProductOf|imgt:mAb_939 imgt:kanjinti™|imgt:isBiosimilarOf|imgt:mAb_97 imgt:StudyProduct_77aa179b-ea76-31b2-9bd8-8288232f87f0|imgt:hasClinicalPhase|imgt:Phase_II imgt:Construct_265|rdfs:label|Construct_265 imgt:Product_b16c8a70-63cb-386b-877e-1df7640dae70|imgt:hasStudyProduct|imgt:StudyProduct_f5830fbe-63ca-3d3f-999b-81b658186793 _:Ba247da921a82ca27f62faea2bc01e5d6|imgt:isDecidedBy|imgt:EMA imgt:11311|rdfs:label|11311 imgt:StudyProduct_bc0d9794-75bd-3a37-ab0d-df9bc7114583|imgt:application_type|Therapeutic imgt:Product_4a3e77b0-665b-30cc-8259-ed42deba2921|rdf:type|obo:NCIT_C51980 _:Ba9ef72b9d6c9661d4a7f82bd9aee9a1a|dc:date|1997-11-05 imgt:Y-Biologics|imgt:produces|imgt:Product_20681962-782d-323a-88be-94240e1b0ace imgt:Product_90ad7f45-90c8-3bb5-9234-c4e52497e415|imgt:isProducedBy|imgt:Roche_F_Hoffmann-La_Roche_Ltd imgt:3'KDE-RS|rdfs:label|3'KDE-RS imgt:Product_f4071a62-44ea-3bb4-9bb6-5c68735042f7|imgt:isProducedBy|imgt:CureTech imgt:FPIA_%5BPROTEIN_4REPEATS%5D2-FC_245|http://semanticscience.org/resource/SIO_000291|imgt:LTB imgt:StudyProduct_ef280720-2f3f-34d6-946f-6e23dd2954ea|rdfs:label|StudyProduct_ef280720-2f3f-34d6-946f-6e23dd2954ea imgt:mAb_879|rdfs:label|mAb_879 imgt:Product_207c84ee-0165-34e2-a44f-35b5b3e342fe|imgt:hasStudyProduct|imgt:StudyProduct_f4807e52-f39a-3b92-ad82-f3540c8f3fcc imgt:Product_508ac5a4-d670-3d35-8997-671e58d97871|imgt:commun_name|anifrolumab-fnia imgt:Large-vessel_vasculitis|imgt:isClinicalIndicationOf|imgt:StudyProduct_a9f55676-d321-39a7-8686-9ee4acfc0ef9 imgt:Product_1aa37c1d-0409-3829-ba45-a5a52bab10aa|imgt:hasStudyProduct|imgt:StudyProduct_364d075a-927b-3ee3-a096-3518c76d8777 imgt:IgG2-kappa-4cys-drug_565|rdfs:label|IgG2-kappa-4cys-drug_565 imgt:OncoMed_Pharmaceuticals|imgt:produces|imgt:Product_6334626c-0b18-3fe9-93f5-4d56b3819ce7 imgt:IgG4-nd_3|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG4-nd.png imgt:Product_c2cf8e9a-b6f0-3bef-989a-2dce59eae331|imgt:isProducedBy|imgt:Thallion_Pharmaceuticals_Inc imgt:GCGR|skos:definition|GCGR (glucagon receptor) imgt:mAb_68|imgt:hasBibliographicReference|pubmed:8360482 imgt:StudyProduct_608de4f2-5325-32d0-8f68-c3fd942fe4a3|rdf:type|obo:NCIT_C174271 imgt:Tropical_spastic_paraparesis_(TSP_model_for_multiple_sclerosis)|rdfs:label|Tropical_spastic_paraparesis_(TSP_model_for_multiple_sclerosis) imgt:Product_2b1f1b1c-e23b-39f4-85da-f7f86eccdf32|imgt:commun_name|G-CSF-HAS imgt:StudyProduct_a1e1919e-055c-39d7-be00-d35393a10a71|rdf:type|obo:NCIT_C174271 imgt:V-kappa-PEG-PEG_499|imgt:isMabReceptorOf|imgt:mAb_499 imgt:J-C-transcript|imgt:hasMoleculeType|imgt:mRNA imgt:StudyProduct_c398d23a-1697-3b9d-be1d-6684184d1772|imgt:hasDecision|_:B64e681c19649b7dc1faf4a9fd2dcd0c6 imgt:Mycosis_fungoides_(MF)_relapsed_or_refractory|rdf:type|obo:NCIT_C185637 imgt:StudyProduct_96f46e52-e9a8-3eeb-8b87-64e1abc367fe|imgt:development_technology| Humanization by CDR grafting imgt:Product_8c9ef270-e03e-375b-ae61-95678879bb35|imgt:isProductOf|imgt:mAb_145 obo:NCIT_C111039|rdfs:subClassOf|obo:NCIT_C1909 imgt:brenzys®|rdfs:label|BRENZYS® imgt:Clone_1033|rdfs:label|Clone_1033 imgt:(scFv-heavy-kappa)-(scFv-heavy-lambda)_1056|rdfs:comment|(scFv - heavy - kappa) - (scFv - heavy - lambda) imgt:IgG1-kappa_803|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png _:B7089ed09133341ece009efadbba4b530|dc:date|2017-08-16 imgt:Clone_90|imgt:isOriginCloneOf|imgt:mAb_90 imgt:IgG1-kappa-4cys-drug_668|imgt:conjugated_with| seco-DUBA imgt:Product_4b923003-44a0-305e-869a-41e26bddedbb|imgt:isProducedBy|imgt:Eli_Lilly imgt:mAb_1111|imgt:inn_name|tixagevimab imgt:ganglioside_GD2_(disialoganglioside_GD2)|imgt:isTargetOf|imgt:IgG1-kappa-%5BPROTEIN%5D2_900 imgt:IgG1-nd_57|obo:RO_0002162|imgt:Hum imgt:StudyProduct_3b1fb8be-81b2-30af-b47a-73a4f15ef025|imgt:hasDecision|_:B25ec13d780ea75311569aa2d6a5e0e00 imgt:mAb_508|imgt:hasImgtStructureEntry|imgt:1AE6 imgt:StudyProduct_f107c835-5ce6-382b-860a-04945c855c8c|rdfs:label|StudyProduct_f107c835-5ce6-382b-860a-04945c855c8c imgt:StudyProduct_0c2e289e-0371-3b3e-b7e2-40c276bbb416|imgt:hasClinicalIndication|imgt:Multiple_myeloma_(MM) imgt:IgG1-kappa_1093|imgt:hasMolecularComponent|imgt:IG imgt:Clone_594|rdf:type|obo:NCIT_C37925 imgt:Product_736e7801-d395-37e7-97ba-6a0f2e81dbaa|imgt:hasStudyProduct|imgt:StudyProduct_ae22c6a7-5041-356e-90ac-920dec712ac8 imgt:1C-LIKE-1F-DOMAIN|rdf:type|imgt:ChainLabels imgt:Segment_765_1|imgt:has_rank|1 imgt:reversal_of_the_antiplatelet_effects_of_ticagrelor_(BRILINTA®_a_blood_thinner_platelet_aggregation_inhibitor)|imgt:isClinicalIndicationOf|imgt:StudyProduct_f194b2c1-54af-36a1-9743-5293ec4e34ae imgt:Fab-G1-kappa_434|imgt:isMabReceptorOf|imgt:mAb_434 imgt:Construct_457|obo:BFO_0000051|imgt:Segment_457_1 imgt:mAb_909|rdfs:label|mAb_909 imgt:RemeGen_Ltd|rdfs:comment|Shandong , China imgt:Segment_750_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:StudyProduct_f4e82d7a-070a-369a-8823-f63259da2a80|rdfs:label|StudyProduct_f4e82d7a-070a-369a-8823-f63259da2a80 imgt:mAb_160|imgt:hasMabReceptor|imgt:IgG1-kappa_160 imgt:IgG1-kappa-4cys-drug_478|imgt:hasMolecularComponent|imgt:IG imgt:mAb_502|imgt:inn_name|lumretuzumab imgt:Product_2521e381-177f-3b68-870d-8cbad0e77285|imgt:commun_name|BAN-2401 imgt:IgG1-kappa_974|rdfs:label|IgG1-kappa_974 imgt:1V-LIKE-CH2-CH3|rdf:type|imgt:ChainLabels imgt:Segment_769_1|rdfs:label|Segment_769_1 imgt:IgG1-kappa_1204|rdf:type|imgt:MAbReceptor imgt:IgG4-kappa-%5BscFv%5D2|rdf:type|imgt:SegmentLabels imgt:StudyProduct_a7a67e43-7d13-32e5-9da3-93ac0b5d6a4f|imgt:hasDecision|_:B9704bcdf71a840956bd30d4e30f0fd56 imgt:Product_8a1dff90-0729-3d27-ae1d-58240f84e744|imgt:isProductOf|imgt:mAb_1291 pubmed:7985543|dc:contributor|Lyons A imgt:mAb_324|imgt:inn_recommended_list|65 (2011) imgt:TNFSF13|rdfs:label|TNFSF13 imgt:Fab-Gamma-3_Kappa|imgt:isDescribedBy|imgt:FAB-GAMMA-3_KAPPA imgt:VZV_(envelope_glycoprotein_H)|rdfs:label|VZV (envelope glycoprotein H) imgt:mAb_291|imgt:hasProduct|imgt:Product_076eabd5-82bc-35a3-9425-216ef5fdee71 imgt:Product_ee3787f8-7750-3f82-81f2-4aaf222c5ffd|imgt:isProductOf|imgt:mAb_499 imgt:IgG4-kappa_1129|rdfs:label|IgG4-kappa_1129 imgt:Construct_790|rdfs:label|Construct_790 imgt:StudyProduct_87e2c5f1-33e0-38ab-a626-e465e699fb62|imgt:application_type|Therapeutic _:Bc4326bf04c540c80ee876419a29acd33|dc:date|1999-02-25 imgt:Product_bf01e52c-681c-3e27-a65a-7e56b7753697|imgt:commun_name|CNTO-1959 imgt:Product_950458ce-5b79-3a87-87fd-0d76107f13a3|imgt:hasStudyProduct|imgt:StudyProduct_27c8d894-d57d-3373-ab92-3279a037a393 imgt:StudyProduct_b3b77be6-ab94-3cd6-9fdf-6223c76c8192|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:GlaxoSmithKline|imgt:produces|imgt:Product_a0a0acd9-1b1b-3f2a-94ce-e55fbf6054e3 imgt:CD33|imgt:isTargetOf|imgt:V-kappa-VH-V-lambda-VH%27_tandAb_1152 _:Bbc5b9f6f061dd4a3b4236c51c02904c8|dc:date|2010-06-01 imgt:Construct_162|rdf:type|imgt:Construct imgt:Construct_140|rdf:type|imgt:Construct imgt:%5BCD4-H-Gamma2_CD4-C-kappa%5D-dimer_82|imgt:hasMolecularComponent|imgt:FPIA _:B8bef2fb76481b53e270919aff7344a0f|imgt:isDecisionOf|imgt:StudyProduct_f6a4d3e0-3533-34cd-b5a3-e402980b80d9 imgt:IgG1-kappa-4lys-drug_490|rdf:type|imgt:MAbReceptor obo:NCIT_C175773|rdf:type|owl:Class imgt:StudyProduct_eba83d89-9fc8-31a7-9337-0a034a6a47cd|imgt:hasClinicalIndication|imgt:Cancers_fallopian_tube imgt:Product_7bade22b-a6c5-3b9d-9336-099f730a41de|imgt:hasStudyProduct|imgt:StudyProduct_0bcfa7a5-b05a-3c0d-b5f4-a2c98ae2a8da imgt:IgG1-kappa_858|obo:RO_0002162|imgt:Chi imgt:mAb_259|imgt:clinical_trials|42 studies found, 20 recruiting imgt:Non-Hodgkin's_lymphoma_(NHL)|imgt:isClinicalIndicationOf|imgt:StudyProduct_4b310d9f-8117-369c-83fa-2873787eda90 imgt:Construct_843|obo:BFO_0000051|imgt:Segment_843_2 imgt:Construct_482|rdf:type|imgt:Construct imgt:mAb_928|rdf:type|imgt:INN pubmed:20848453|imgt:isBibliographicReferenceOf|imgt:mAb_350 imgt:Product_d8a5ae73-24a6-3fa8-9ce9-ad6827deda46|imgt:hasStudyProduct|imgt:StudyProduct_eecf5ce4-fbe7-3768-b545-33e1eb7be4a0 imgt:Segment_1089_1|rdfs:label|Segment_1089_1 imgt:CureTech|rdfs:label|CureTech imgt:mAb_755|imgt:hasProduct|imgt:Product_bec82608-56a6-34c7-8eb5-2ffa2f5406da imgt:Merus_NV|rdf:type|obo:NCIT_C54131 imgt:has_rank|rdfs:label|has_rank _:Bfc0bdff0b78538e269a5fba4858dcf52|imgt:hasStatut|imgt:approval imgt:Construct_533|imgt:hasImgtLabel|imgt:IgG4-kappa imgt:StudyProduct_5a1d70be-9799-3766-a0cf-3fcdf0fffb95|imgt:hasClinicalPhase|imgt:Phase_I/II _:Be320747c879b25ef53049c42d2465304|imgt:isDecidedBy|imgt:EC _:B3b6d4ee9a8493e6450c5b06d1b9018ed|dc:date|1996-06-28 imgt:rearranged|rdfs:label|rearranged imgt:Segment_580_2|imgt:has_rank|2 imgt:11256|imgt:isImgtStructureEntryOf|imgt:mAb_1030 imgt:StudyProduct_3ce51bf4-2da7-3b9c-8a07-55b43d4693c3|imgt:application_type|Therapeutic imgt:Product_a77a82e8-1666-32c6-9125-86cdca4d3f25|imgt:hasStudyProduct|imgt:StudyProduct_683283a5-8ee3-3684-8cd5-82144f28dbc5 imgt:StudyProduct_46126144-d789-3994-b8cc-2669cb607f7e|imgt:isStudyProductOf|imgt:Product_49c2056b-e4db-3d7e-aeaa-1e329f6571e9 imgt:Systemic_lupus_erythematosus_(SLE)|imgt:isClinicalIndicationOf|imgt:StudyProduct_171f4271-1a0a-3d85-a978-4adf1ec3b14d imgt:Clone_835|rdfs:label|Clone_835 imgt:StudyProduct_7ae73e7a-7e50-321a-8cda-c099c16e56fc|imgt:isStudyProductOf|imgt:Product_0a8c1189-94c5-3c97-8084-ac55604f60a3 imgt:Segment_83_1|obo:BFO_0000050|imgt:Construct_83 imgt:pelmeg®|rdfs:comment| PELMEG® developed by Mundipharma Corporation (Dublin Ireland) approved by EMA on September 2018. EMEA/H/C/004700 Same clinical indications as NEULASTA®. _:Be16a091924adb04ee88db3e3447080c7|rdf:type|obo:NCIT_C53285 obo:NCIT_C1476|rdf:type|owl:Class imgt:Tanox_Inc|rdfs:label|Tanox Inc. imgt:Product_48254897-faf9-3351-a974-a0f1aae477e6|imgt:commun_name|BAY 79-4620 imgt:StudyProduct_bc96394e-4266-3b0c-9ff1-ec9e290b0e3f|rdf:type|obo:NCIT_C174271 imgt:has_fcode_qualif|rdf:type|owl:AnnotationProperty imgt:Product_0c4ce40c-4004-3873-ac20-3d6e604874e8|imgt:commun_name|BIIB029 imgt:mAb_771|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=771 imgt:StudyProduct_8bb54045-8ad1-3474-9b0d-c2ec2a570bdb|imgt:hasClinicalPhase|imgt:Phase_III imgt:mAb_967|rdfs:label|mAb_967 imgt:influenza_B_virus_hemagglutinin|skos:definition|influenza B virus hemagglutinin imgt:StudyProduct_7dd98b78-286f-3866-841b-d82c5914a07a|imgt:application_type|Therapeutic imgt:StudyProduct_3adc6318-e634-3534-9fb2-a10d3048eb2f|rdfs:label|StudyProduct_3adc6318-e634-3534-9fb2-a10d3048eb2f imgt:Product_b5e598b6-8945-316b-8c71-ee8e8326048b|imgt:commun_name|OncoScint CR/OV imgt:StudyProduct_ec10ad9a-e25c-3579-a254-0285c1909c30|imgt:isStudyProductOf|imgt:Product_39ec5d7e-7e56-320e-81b0-dd2a88a3adf0 imgt:Segment_246_2|imgt:has_rank|2 imgt:StudyProduct_62b47614-c15e-3d58-853f-5748943ec9d8|rdfs:label|StudyProduct_62b47614-c15e-3d58-853f-5748943ec9d8 imgt:Segment_880_1|rdf:type|imgt:Segment imgt:StudyProduct_33faeb62-9c6d-3140-98f2-c046c2f59f9b|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:mAb_48|rdf:type|obo:NCIT_C1909 imgt:Product_ae26fe5d-0957-3750-9fd4-e84dc4303b03|imgt:hasStudyProduct|imgt:StudyProduct_dc3d33f4-c22a-3435-b95f-e883651517dc imgt:StudyProduct_14463583-eb30-3e6b-b17d-75f1022568ed|rdfs:label|StudyProduct_14463583-eb30-3e6b-b17d-75f1022568ed imgt:StudyProduct_60dfa53b-3345-3e41-ac21-3e5522a41ada|rdf:type|obo:NCIT_C174271 imgt:mAb_562|imgt:hasProduct|imgt:Product_0d23f5a7-b8cb-3eb8-ba07-41a57852fdf3 imgt:Solid_tumors|imgt:isClinicalIndicationOf|imgt:StudyProduct_043adbe2-5122-3b2d-b5c9-7dcefb38c2c7 imgt:IG-GAMMA_KAPPA|rdf:type|imgt:StructureLabels pubmed:8360482|imgt:isBibliographicReferenceOf|imgt:mAb_68 imgt:5ICX|imgt:isImgtStructureEntryOf|imgt:mAb_151 imgt:StudyProduct_6609c77d-5c25-3143-a062-e1fd5c12a176|imgt:isStudyProductOf|imgt:Product_e606d79d-bde1-3cc6-a544-20c1bf6683c4 imgt:Product_5024ee29-d1ef-33f4-9ff5-34e4c3a98933|imgt:hasStudyProduct|imgt:StudyProduct_c41a5aad-60fe-3bea-a5d7-9fe2d148dc75 imgt:NGM_Biopharmaceuticals_Inc|rdf:type|obo:NCIT_C54131 imgt:C5|obo:RO_0002162|imgt:Homsap imgt:Construct_882|obo:BFO_0000051|imgt:Segment_882_1 imgt:Construct_92|rdf:type|imgt:Construct imgt:FPIA_%5BPROTEIN_VLIKE%5D2-FC_212|rdf:type|imgt:MAbReceptor imgt:Peripheral_T/NK_cell_lymphoma|rdf:type|obo:NCIT_C185637 imgt:Product_66c1ccb4-fede-3350-b3b2-b3f8a1777ea0|rdfs:label|Product_66c1ccb4-fede-3350-b3b2-b3f8a1777ea0 imgt:PCSK9|rdfs:label|PCSK9 imgt:Product_1ee293d6-44ea-3bcb-84c3-b34b51c264d4|imgt:hasStudyProduct|imgt:StudyProduct_424bbbb3-c7ce-334b-8c8c-6862d1c2610c imgt:Product_3ac0b998-f720-388a-bb51-08f38d12f3e9|imgt:hasStudyProduct|imgt:StudyProduct_ef02f05c-ea13-311e-975a-324b5b147726 imgt:StudyProduct_bb80f2f4-20e6-3b38-9f95-aa0392d89512|imgt:hasClinicalPhase|imgt:Phase_M imgt:Clone_63|rdfs:label|Clone_63 imgt:Construct_1280|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Clone_1126|imgt:clone_name|501-14 imgt:StudyProduct_a3cc3c99-76ff-3041-8a15-26c76e38ca13|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_b6178625-3cf7-3178-960f-6d7ef1f13a42|imgt:hasClinicalIndication|imgt:Poison_oak imgt:StudyProduct_7c7d1559-1e96-3c5e-9e42-3aac703c1921|imgt:isStudyProductOf|imgt:Product_f54c6043-6277-3c37-b202-92f1deb4aaff imgt:IgG4_Lambda|imgt:isDefinedBy|imgt:IG-Light-Lambda-IGL _:Bf95e381016d47cd1f0cd959186044e2d|dc:date|2016-11-10 imgt:StudyProduct_7e5efcc1-687c-365c-a2e5-3aca55e7574e|imgt:application_type|Therapeutic imgt:IgG1-Fab-kappa-lambda_1286|rdfs:comment|IgG1-Fab-kappa-lambda imgt:IgG2-G4-kappa_37|obo:RO_0002162|imgt:Hum imgt:PEPTIDE-XTEN_703|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/PEPTIDE-XTEN.png imgt:LINGO1|skos:definition|LINGO1 (leucine-rich repeat and Ig-like domain-containing nogo receptor-interacting protein 1, LINGO-1, leucine-rich repeat neuronal protein 1, LERN1, leucine-rich repeat neuronal protein 6A, LRRN6A) imgt:Segment_527_1|rdf:type|imgt:Segment imgt:Product_f6c7a871-ae54-30b2-abf8-50b6400072df|rdf:type|obo:NCIT_C51980 imgt:amjevita™|rdfs:comment| AMJEVITA™ (adalimumab-atto ABP 501) developed by Amgen (Thousand Oaks CA USA) approved by FDA on September 23 2016 for multiple inflammatory diseases (it is the fourth biosimilar - and second mAb - approved by FDA press release Same clinical indications as HUMIRA®. imgt:Clone_498|rdfs:label|Clone_498 imgt:Product_885d502e-12f5-381c-9601-6d157171b81e|rdf:type|obo:NCIT_C51980 imgt:10498|imgt:isImgtStructureEntryOf|imgt:mAb_720 imgt:Segment_1221_1|rdfs:label|Segment_1221_1 obo:NCIT_C179065|rdfs:subClassOf|obo:NCIT_C1909 imgt:Construct_497|rdf:type|imgt:Construct imgt:mAb_529|imgt:clinical_trials|9 studies found, 1 recruiting imgt:Segment_153_1|rdfs:label|Segment_153_1 imgt:Product_8ab7fc81-b8d6-308e-9064-5a153be43d1b|imgt:isProducedBy|imgt:Aravive_Biologics_Inc imgt:Construct_661|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:mAb_327|imgt:inn_name|rontalizumab imgt:StudyProduct_a3b055d6-b079-3da5-982f-b3d60dd4efd4|rdf:type|obo:NCIT_C174271 imgt:Product_d7fdef9d-ffc1-3cfa-a0c4-55b5452505c5|imgt:commun_name|Alb-IFNA2 R23 (608) imgt:StudyProduct_df96c908-31f4-3b5e-bc30-3919b5ae18fb|imgt:hasClinicalPhase|imgt:Phase_I imgt:IgG4-kappa_385|imgt:hasMolecularComponent|imgt:IG imgt:IgG1-kappa_176|imgt:hasConstruct|imgt:Construct_176 imgt:Anemia_associated_with_cancer|rdf:type|obo:NCIT_C185637 imgt:Product_3086b99e-8c37-3a44-8aaf-14e046e82b3b|imgt:hasStudyProduct|imgt:StudyProduct_db545417-635e-3438-a88d-54bebe760e5b imgt:IgG1-nd_6|imgt:isMabReceptorOf|imgt:mAb_6 obo:NCIT_C90578|rdf:type|owl:Class imgt:StudyProduct_e395edb7-2255-390e-9f03-4a940b773bc4|imgt:application_type|Therapeutic imgt:StudyProduct_01549b7c-b89b-3100-ab84-41fa0b04e2a5|rdfs:label|StudyProduct_01549b7c-b89b-3100-ab84-41fa0b04e2a5 imgt:Segment_439_1|rdfs:label|Segment_439_1 imgt:mAb_463|imgt:inn_number|9746 imgt:Hypercholesterolemia|imgt:isClinicalIndicationOf|imgt:StudyProduct_01521ddb-ecdc-3ff5-8659-d40f72c1207d _:Bedea11eb5faef5d5433912224b3c1ff3|rdf:type|obo:NCIT_C53285 imgt:StudyProduct_ab0a5643-24b0-395f-bf6c-b53b8211bd94|imgt:hasClinicalIndication|imgt:Cancers imgt:Product_e521e71e-0d27-3157-a807-f8780c379245|imgt:hasStudyProduct|imgt:StudyProduct_10017535-53ac-3035-a341-863eeaff2240 imgt:Product_e6cefd95-eb16-32aa-adc9-813b1166be33|imgt:commun_name|SAR650984 imgt:StudyProduct_1bffc5d9-6be7-3f6f-aec0-82c150cfc547|imgt:hasClinicalIndication|imgt:Asthma imgt:Cancers_non-small_cell_lung_(NSCLC)|imgt:isClinicalIndicationOf|imgt:StudyProduct_bc948b67-2463-3ad7-990e-7a42c8101991 imgt:StudyProduct_63c5c2f7-4314-3a62-9ed6-730a7b512559|imgt:hasClinicalIndication|imgt:Acute_gout imgt:mAb_767|imgt:inn_name|mirikizumab imgt:Product_b874e91f-5c72-30ea-8bd2-f0bf2e6cc591|imgt:commun_name|SAR 441344 imgt:Product_73e835ec-f2f0-3c7f-9278-25c653d1147e|imgt:commun_name|cG250 imgt:StudyProduct_db1471ac-0b14-38e9-ae83-f5e6efc97f5f|imgt:isStudyProductOf|imgt:Product_c7810095-aebe-3853-904f-69aab48efb59 imgt:ERBB2|imgt:isTargetOf|imgt:IgG1-kappa-4cys-drug_896 imgt:mAb_17|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=17 imgt:FPIA_%5BPROTEIN_VLIKE%5D2-1S-FC_247|http://semanticscience.org/resource/SIO_000291|imgt:CD80 imgt:StudyProduct_31ef0b93-ca9d-32bb-83cc-86d57abf70c4|rdf:type|obo:NCIT_C174271 imgt:IgG1-kappa-4lys-drug_387|imgt:hasMolecularComponent|imgt:IG imgt:Segment_1073_1|imgt:has_rank|1 imgt:StudyProduct_7ff14d1e-e1ee-32c2-a20f-569d99384d58|rdfs:label|StudyProduct_7ff14d1e-e1ee-32c2-a20f-569d99384d58 imgt:IgG1-kappa_416|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:StudyProduct_4424f4cb-1edc-3c5e-9c61-b3a2bfc1415a|imgt:application_type|Therapeutic imgt:IgG1-kappa_768|rdfs:comment|IgG1 - kappa imgt:Kidney_transplantation_prevention_of_delayed_graft_function_(DGF)|rdf:type|obo:NCIT_C185637 imgt:mAb_568|rdf:type|imgt:INN imgt:1V-1C-LIKE_1V-1C-LIKE_1V-1C-LIKE_1V-1C-LIKE|rdf:type|imgt:RPILabel imgt:StudyProduct_e71f82cd-4d55-3f0e-bac1-74d5fa41efb3|imgt:application_type|Therapeutic imgt:Construct_264|obo:BFO_0000051|imgt:Segment_264_1 imgt:IgG1-kappa_263|imgt:isMabReceptorOf|imgt:mAb_263 imgt:IgG1-kappa_371|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:mAb_846|imgt:inn_name|cemiplimab imgt:Product_16d030ee-d4af-35e5-af65-2c8a5b6b131f|imgt:isProductOf|imgt:mAb_1081 imgt:peptidyl_linker|rdfs:label|peptidyl linker imgt:Scarring|imgt:clinical_domain|Dermatology imgt:StudyProduct_32ef0399-42b0-3bc5-8e21-99bfc436083d|rdfs:label|StudyProduct_32ef0399-42b0-3bc5-8e21-99bfc436083d imgt:Product_bf813acf-a5a5-3c97-95c6-5809bda944e1|imgt:commun_name|IBI 322 imgt:IgG1-kappa-S239C_2cys-drug_552|imgt:isMabReceptorOf|imgt:mAb_552 imgt:Product_6070f2ac-d903-337d-beab-a7ca53d7c933|rdf:type|obo:NCIT_C51980 imgt:mAb_1272|imgt:imgt_note| On Jan 1, 2019, HJB and MabSpace Biosciences announce the fusion of the two companies to creat Transcenta Holding Ltd. (Transcenta), a fully-integrated biotherapeutics company. imgt:StudyProduct_14857b94-bdbd-375d-bdb5-a38f05a59a47|imgt:development_technology| MorphoSys's HuCAL® phage library imgt:StudyProduct_d326469e-6f88-3537-a40c-8ab4d0953fec|rdfs:label|StudyProduct_d326469e-6f88-3537-a40c-8ab4d0953fec imgt:StudyProduct_47845097-3a00-3b73-9d59-751c4db6a7ee|imgt:hasClinicalPhase|imgt:Phase_I imgt:StudyProduct_3c1e5518-5900-3b45-8c8e-375084cd177e|imgt:hasClinicalIndication|imgt:Lymphoma imgt:Product_508ac5a4-d670-3d35-8997-671e58d97871|imgt:hasStudyProduct|imgt:StudyProduct_bb14a1cf-81cc-3fd3-b586-0eb76136c45f imgt:mAb_1237|imgt:inn_proposed_list|126 (2022) imgt:Product_08d8d415-5012-3fff-89bc-339b87dd0ab0|imgt:hasStudyProduct|imgt:StudyProduct_7d240539-92d2-38a0-9db1-90963f0f98d8 imgt:Product_56576134-cfbd-35a6-b65a-05844543f13f|imgt:hasStudyProduct|imgt:StudyProduct_1bd034c3-034e-3ec1-99c5-e7a5d97ae863 imgt:Segment_124_1|imgt:has_rank|1 imgt:Construct_718|obo:BFO_0000051|imgt:Segment_718_1 imgt:StudyProduct_5ff62102-e848-3f73-a032-36953e1cfc52|imgt:hasClinicalIndication|imgt:Crohn's_disease_(CD) obo:NCIT_C80038|rdf:type|owl:Class imgt:IgG1-kappa-4cys-drug_814|obo:RO_0002162|imgt:Homsap imgt:alymsys®|imgt:isBiosimilarOf|imgt:mAb_24 imgt:MUC1|imgt:isTargetOf|imgt:IgG1-nd_49 imgt:Fab-G1-kappa_287|imgt:isMabReceptorOf|imgt:mAb_287 imgt:StudyProduct_a6408207-9703-365a-badb-e1f481cce777|imgt:hasClinicalIndication|imgt:Chronic_lymphocytic_leukemia_(CLL) imgt:Segment_628_1|imgt:segment_detail|*b (R46,H57) 24-188 imgt:IgG1-kappa-4cys-drug2_1208|rdfs:label|IgG1-kappa-4cys-drug2_1208 imgt:Product_1ff282bc-eb72-3378-9c95-2ad8aac8ba1d|imgt:hasStudyProduct|imgt:StudyProduct_9356e1ff-b86a-345b-99f2-b7aeb630222c imgt:Coat’s_disease|rdfs:label|Coat’s_disease imgt:Segment_1224_1|obo:BFO_0000050|imgt:Construct_1224 imgt:Product_5361ee36-3770-3139-a6be-27e3520b6392|imgt:commun_name|SGN-70 imgt:Product_076eabd5-82bc-35a3-9425-216ef5fdee71|imgt:commun_name|PDL-063 imgt:mAb_1183|imgt:inn_number|11734 imgt:9028|rdfs:label|9028 imgt:StudyProduct_5ba3245c-13cb-3e17-a35e-fe9bd9ab660b|imgt:hasDecision|_:B2901adce123595f06b05e84dc8a91550 imgt:HOR-CTP_1051|rdfs:label|HOR-CTP_1051 _:Bf058fcc2ea44da4bf609fa7bdc5a2bcd|imgt:hasDesignation|imgt:Orphan_drug imgt:IgG1-kappa_298|rdfs:comment|IgG1 - kappa imgt:mAb_386|imgt:hasMabReceptor|imgt:IgG4-kappa_386 imgt:StudyProduct_b499475d-1ffb-3506-b588-4b1369c49104|rdf:type|obo:NCIT_C174271 imgt:mAb_1011|rdf:type|imgt:INN imgt:MH2|imgt:isTargetOf|imgt:FPIA_%5BPROTEIN-PROTEIN-PROTEIN-PROTEIN%5D2-3S-FC_611 imgt:StudyProduct_2b766eec-8b24-3d41-a7f5-632494792905|imgt:hasClinicalPhase|imgt:Phase_II imgt:mAb_1200|imgt:hasOriginClone|imgt:Clone_1200 _:Bade5b99bbe5312bb8ea1b51859c6bd5d|imgt:hasStatut|imgt:approval imgt:TR|imgt:isTargetOf|imgt:IgM-kappa_129 imgt:mAb_908|imgt:inn_proposed_list|120 (2018) imgt:StudyProduct_caefcc10-c9e9-3bb3-8576-158012138944|imgt:hasClinicalIndication|imgt:Neoplasms imgt:Product_00b8895b-c794-3a80-a7c8-7629892c32c2|imgt:commun_name|DS-8201 imgt:IgG1-lambda-4lys-drug_656|obo:RO_0002162|imgt:Homsap imgt:Product_b8b97efb-86a2-33a6-b3a8-01f88c1daea3|imgt:hasStudyProduct|imgt:StudyProduct_14c43a92-6218-3954-aa5b-a9e5fa1474b2 imgt:StudyProduct_330d1681-6a7e-3450-9bbd-4065f27813aa|imgt:isStudyProductOf|imgt:Product_78800bde-0415-316d-9569-aa8f4930c5fb imgt:Product_68afb854-61e9-3368-bcb1-806b4a0975fc|imgt:commun_name|ONO-4482 pubmed:15994800|dc:contributor|Marissen WE imgt:mAb_1061|imgt:inn_proposed_list|123 (2020) imgt:Segment_1109_1|imgt:hasImgtLabel|imgt:IgG1-lambda imgt:benepali®|rdf:type|obo:NCIT_C156644 imgt:StudyProduct_d571aff8-5be1-3eb0-9067-8bae72728f52|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells obo:NCIT_C132339|rdf:type|owl:Class imgt:KIT|rdfs:label|KIT imgt:RGMA|imgt:isTargetOf|imgt:IgG1-kappa_1151 _:B05741806e61256feffc827e962130db5|imgt:isDecidedBy|imgt:EC imgt:IL1R1|rdf:type|obo:NCIT_C25702 imgt:MHEngineeredLabel|skos:definition|Major histocompatibility engineered imgt:mAb_895|imgt:inn_number|10932 imgt:StudyProduct_34059830-dab5-3ad5-9c3b-bbbb454ba9e9|imgt:hasClinicalPhase|imgt:Phase_I imgt:Segment_794_1|imgt:hasImgtLabel|imgt:VH-VH-H-Gamma4_VL-VL-C-kappa imgt:StudyProduct_054e1b6c-5c9b-3a23-85f4-2725ae559110|imgt:hasClinicalPhase|imgt:Phase_II imgt:StudyProduct_d1accc69-7ed8-3ef7-b9f6-a21126422aa9|imgt:hasClinicalPhase|imgt:Phase_II _:B7c505214f888e6446faca8c0560b626f|rdf:type|obo:NCIT_C53285 imgt:Product_c9cafb67-7c5b-36ee-93fb-4c7df9648b85|imgt:commun_name|MSL109 imgt:mAb_482|imgt:inn_recommended_list|72 (2014) imgt:mAb_753|imgt:inn_number|10473 imgt:Construct_569|rdfs:label|Construct_569 imgt:CA9|obo:RO_0002162|imgt:Homsap obo:NCIT_C68821|skos:definition|A rule or order issued by an authority stating what may or may not be done or how something must be done. _:Bc2a59547244489488a0d39580a99e304|imgt:hasStatut|imgt:approval imgt:Clone_20|rdfs:label|Clone_20 imgt:TIR|rdfs:label|TIR imgt:Segment_1013_1|rdfs:label|Segment_1013_1 imgt:Segment_624_1|rdf:type|imgt:Segment imgt:mAb_389|imgt:inn_number|9486 imgt:IgG1-kappa-4cys-drug_571|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa-4cys-drug.png imgt:mAb_170|imgt:inn_name|bertilimumab imgt:mAb_264|imgt:inn_proposed_list|91 (2004) obo:NCIT_C85475|rdfs:subClassOf|obo:NCIT_C1909 imgt:11987|rdf:type|obo:NCIT_C25402 imgt:Product_1c53045c-f69d-32cc-92d5-edd603543aa2|imgt:isProductOf|imgt:mAb_91 imgt:mAb_1159|imgt:hasMabReceptor|imgt:IgG4-kappa-protein_1159 _:B8e26f408e45bdf91a65a9bf5882afe15|dc:date|2015-01-21 imgt:StudyProduct_fcbf841b-9d17-33d8-bf41-d4bbd626cbb6|rdfs:label|StudyProduct_fcbf841b-9d17-33d8-bf41-d4bbd626cbb6 imgt:StudyProduct_105a4697-29fc-3299-83ce-6af63d477662|imgt:hasClinicalPhase|imgt:Phase_I/II imgt:IgG4-kappa-protein_1019|rdfs:label|IgG4-kappa-protein_1019 imgt:Product_0efba242-cde9-3874-a460-fdde00169ee1|rdf:type|obo:NCIT_C51980 imgt:mAb_1162|imgt:inn_name|acazicolcept imgt:IgG1-kappa-2cys-drug_959|imgt:isMabReceptorOf|imgt:mAb_959 imgt:Segment_323_1|imgt:has_rank|1 imgt:V-LAMBDA-VH-CH2-CH3|skos:definition|Chain comprising a V-LAMBDA, a VH domains, CH2 and CH3 imgt:mAb_148|imgt:inn_recommended_list|38 (1997) imgt:Segment_870_1|imgt:has_rank|1 imgt:Huntington’s_disease|imgt:clinical_domain|Neurology imgt:Clone_294|rdf:type|obo:NCIT_C37925 imgt:IL15RA_(interleukin_15_receptor_subunit_alpha_CD215_IL-15RA)-20-mer_Gly-Ser_linker-IL15_(interleukin_15_IL-15)|imgt:construction_detail|Fusion - IL15RA (interleukin 15 receptor subunit alpha, CD215, IL-15RA) - 20-mer Gly-Ser linker - IL15 (interleukin 15, IL-15) imgt:Paroxysmal_nocturnal_hemoglobinuria_(PNH)|imgt:clinical_domain|Hematology imgt:FN2-1|skos:definition|Fibronectin II imgt:Product_3fa823ee-5424-3729-b15a-e24345c3efb9|imgt:commun_name|MM-302 imgt:mAb_1117|imgt:inn_name|lerodalcibep imgt:mAb_301|rdfs:label|mAb_301 imgt:Construct_323|rdf:type|imgt:Construct imgt:StudyProduct_a58de7d6-5c2f-36d9-a947-8febd94a17f1|rdfs:label|StudyProduct_a58de7d6-5c2f-36d9-a947-8febd94a17f1 imgt:Segment_455_1|obo:BFO_0000050|imgt:Construct_455 imgt:IgG1-kappa_1120|imgt:isMabReceptorOf|imgt:mAb_1120 imgt:StudyProduct_9cd1533d-275c-316f-9ca4-783d18d335e9|rdfs:label|StudyProduct_9cd1533d-275c-316f-9ca4-783d18d335e9 imgt:mAb_24|imgt:hasBiosimilar|imgt:aybintio® imgt:Pulmonary_Fibrosis|imgt:clinical_domain|Pulmonary, Respiratory diseases imgt:mAb_852|imgt:inn_recommended_list|81 (2019) imgt:Segment_953_1|rdfs:label|Segment_953_1 obo:NCIT_C166733|rdf:type|owl:Class imgt:StudyProduct_c9893c28-0b44-3b20-bbdc-f42c12eebae7|rdf:type|obo:NCIT_C174271 imgt:Segment_772_1|rdfs:label|Segment_772_1 imgt:CytomX_Therapeutics_Inc|imgt:produces|imgt:Product_7e5d1d6d-b55c-3e83-81ba-8f67e321c93b imgt:IgG4-nd_442|rdfs:label|IgG4-nd_442 imgt:10296|rdfs:label|10296 imgt:StudyProduct_d59c5999-c730-3c35-8ac7-4595f774bc89|rdf:type|obo:NCIT_C174271 imgt:Segment_360_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:StudyProduct_9176e0ea-83fd-3dbe-979a-a20148b486ca|imgt:hasClinicalPhase|imgt:Phase_I imgt:9475|imgt:isImgtStructureEntryOf|imgt:mAb_376 _:B4f59a5c8713a63eeb2695675c4dfd339|imgt:isDecidedBy|imgt:FDA imgt:mAb_864|imgt:inn_recommended_list|81 (2019) imgt:Product_1d32d5b1-99c8-31ab-9a21-acfa4c132ab7|rdf:type|obo:NCIT_C51980 imgt:Segment_981_1|obo:BFO_0000050|imgt:Construct_981 imgt:StudyProduct_5e4004b3-1015-3051-a220-2854ddad8641|rdf:type|obo:NCIT_C174271 imgt:L-KAPPA-TOXIN|skos:definition|Ig-Light-Kappa chain comprising a V-KAPPA, a C-KAPPA and TOX domain imgt:Non-Hodgkin's_lymphoma_(NHL)_follicular_CD20_positive_relapsed_or_refractory_low_grade|rdfs:label|Non-Hodgkin's_lymphoma_(NHL)_follicular_CD20_positive_relapsed_or_refractory_low_grade imgt:Product_92683334-b9aa-397f-afad-ef30225a0323|imgt:hasStudyProduct|imgt:StudyProduct_eb3b48a7-f6ff-3115-9280-0baaaddd2d9d imgt:mAb_999|imgt:inn_name|adebrelimab imgt:CPCA_PEPTIDE-PEG-FC_673|rdfs:comment|CPCA_PEPTIDE-PEG-FC imgt:mAb_407|imgt:inn_recommended_list|68 (2012) imgt:Construct_1098|imgt:isConstructOf|imgt:FPIA_%5BPROTEIN%5D2-FC_1098 imgt:AstraZeneca|imgt:produces|imgt:Product_8bd206f8-aceb-33f2-82ee-f4b3427759f5 imgt:J-transcript|imgt:hasMoleculeUnit|imgt:transcript_unit imgt:Product_c7be9dd8-8b8f-38bc-9841-af5bf6b87cd0|imgt:isProducedBy|imgt:Alpine_Immune_Sciences imgt:Product_7a63f972-9c9e-3455-92cd-81ee704c6884|imgt:hasStudyProduct|imgt:StudyProduct_76beb6a6-708c-38dd-9e66-0e207c521204 imgt:StudyProduct_3cf885c8-c7b2-3a9b-b637-6fadb2324fb9|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:Product_d37750e2-ebcd-3a4a-802e-29afea0dbc7d|imgt:isProductOf|imgt:mAb_976 imgt:mAb_388|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=388 imgt:Segment_360_1|rdf:type|imgt:Segment imgt:11846|rdfs:label|11846 imgt:StudyProduct_2ceaa53e-6ad0-350e-8c2b-77078eee2f94|imgt:application_type|Therapeutic _:Beed6dc7c14342bd0025c0e849b1c4342|imgt:isDecidedBy|imgt:FDA imgt:CPCA_PROTEIN-FC_820|imgt:fused_with| Homo sapiens IGHG4 Fc (Fragment constant) imgt:StudyProduct_f9931cb1-61ae-324e-a2be-bf35bad4a04b|imgt:application_type|Therapeutic imgt:Segment_504_1|rdf:type|imgt:Segment imgt:StudyProduct_8fa0a452-5792-33e2-a012-f986e36e6fca|imgt:hasClinicalPhase|imgt:Phase_M imgt:Clone_62|imgt:isOriginCloneOf|imgt:mAb_62 imgt:Product_61d1bcf7-a2ee-33c8-8e6e-422bfd8da242|rdf:type|obo:NCIT_C51980 imgt:Product_6fff76bc-baa0-3e3c-9cf8-839e804eb2ac|imgt:isProductOf|imgt:mAb_610 imgt:mAb_60|imgt:inn_number|8232 imgt:Severe_combined_immunodeficiency_(SCID)|rdf:type|obo:NCIT_C185637 imgt:10646|rdfs:label|10646 imgt:RPI-Group|rdf:type|owl:Class imgt:Adaptimmune_LLC|rdf:type|obo:NCIT_C54131 imgt:StudyProduct_8ce86eff-8b49-3cde-a769-b0f3f57d671f|imgt:hasDecision|_:B6982ca1cacfe030f2400e3b5ff18ed97 imgt:V-D-J-gene|imgt:hasMoleculeType|imgt:gDNA imgt:Product_76a068f8-e304-3746-aabc-b40c1b23f548|imgt:commun_name|CTB 012 imgt:IgG1-kappa_1025|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:Segment_1204_1|rdf:type|imgt:Segment imgt:StudyProduct_eb4d9582-e479-3f96-a6a0-a55b7ce7bed5|imgt:application_type|Therapeutic imgt:IgG1-kappa_502|rdfs:comment|IgG1 - kappa imgt:StudyProduct_90fd282e-02f9-398a-be74-6e57271986c8|imgt:isStudyProductOf|imgt:Product_02550586-7a1b-3018-bf60-0ad7c06c9f86 imgt:mAb_282|imgt:inn_proposed_list|84 (2000) imgt:11927|rdf:type|obo:NCIT_C25402 imgt:Product_7832c9e8-c4d7-3ca7-8c44-6880985116a0|imgt:isProductOf|imgt:mAb_683 imgt:Product_f4dda718-cf10-3efb-a60a-ef580f59896d|imgt:commun_name|BI 767551 imgt:mAb_1277|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=1277 imgt:mAb_427|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=427 imgt:Product_d4257b3b-e73f-39d7-9439-417ecbb213f1|imgt:isProducedBy|imgt:JCR_Pharmaceuticals_Co_Ltd imgt:StudyProduct_7ed7242f-3444-378f-812e-8ff84c1f6368|rdf:type|obo:NCIT_C174271 imgt:Product_38467291-7ffe-3c19-9668-d0dbeafcd182|imgt:commun_name|AMG-256 imgt:mAb_761|imgt:inn_name|spartalizumab obo:NCIT_C152635|rdf:type|owl:Class imgt:Construct_1188|imgt:isConstructOf|imgt:IgG1-kappa_1188 imgt:_fucosyltransferase-deficient_CHO_(Chinese_Hamster_Ovary)|imgt:isExpressionSystemOf|imgt:StudyProduct_3e64b023-44c7-39c1-bd6a-db6275fc93ef imgt:scFv-kappa-heavy-CD8A_(CO-TM)-TNFRSF9_(CY)-CD247_873|rdf:type|imgt:MAbReceptor imgt:Product_c2cf8e9a-b6f0-3bef-989a-2dce59eae331|rdfs:label|Product_c2cf8e9a-b6f0-3bef-989a-2dce59eae331 imgt:MAbReceptor_99|rdfs:label|MAbReceptor_99 imgt:9653|imgt:isImgtStructureEntryOf|imgt:mAb_422 imgt:9648|rdf:type|obo:NCIT_C25402 imgt:mAb_593|rdfs:label|mAb_593 imgt:IgG4-kappa-lambda_1183|http://semanticscience.org/resource/SIO_000291|imgt:bispecific imgt:mAb_480|imgt:inn_name|fletikumab imgt:mAb_379|rdf:type|obo:NCIT_C78844 imgt:Cancers_colorectal_(CRC)|imgt:isClinicalIndicationOf|imgt:StudyProduct_3da0db8d-1eec-321a-9900-792118d84944 imgt:REMD_Biotherapeutics_Inc|rdfs:label|REMD Biotherapeutics, Inc _:Bbcdffdd6ce2f37d5309d9b24cb4ab037|dc:date|2018-01-08 imgt:mAb_297|imgt:hasImgtStructureEntry|imgt:9051 imgt:IgG1-nd_67|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-nd.png imgt:mAb_370|rdf:type|imgt:INN imgt:AbbVie_Inc|imgt:produces|imgt:Product_7a63f972-9c9e-3455-92cd-81ee704c6884 imgt:Segment_213_2|obo:BFO_0000050|imgt:Construct_213 imgt:VH-CH1|imgt:describes|imgt:IG-Heavy-Gamma-2-IGHG2 imgt:10187|rdf:type|obo:NCIT_C25402 imgt:StudyProduct_0fe403ef-7b3a-3686-8283-a4cb356a3e53|imgt:hasDecision|_:B6c0e3dfb428e18cb60a1ed48a1479f8f imgt:Allergy|imgt:isClinicalIndicationOf|imgt:StudyProduct_1e2bc35b-44f3-3a3b-8938-77751325cdeb imgt:PROTEIN_1DOMAIN_626|imgt:hasConstruct|imgt:Construct_626 imgt:StudyProduct_f95e7e1c-4453-3bfe-835c-1245dfb30b90|imgt:development_technology| Azymetric™ imgt:11958|imgt:isImgtStructureEntryOf|imgt:mAb_1277 imgt:PROTEIN_1DOMAIN-PEG_628|http://semanticscience.org/resource/SIO_000291|imgt:IFNAR2 imgt:StudyProduct_76bc383b-6576-3677-b0c2-72abff042665|rdfs:label|StudyProduct_76bc383b-6576-3677-b0c2-72abff042665 imgt:Construct_134|imgt:isConstructOf|imgt:F(ab%27)2-G1-nd_134 imgt:Clone_111|imgt:isOriginCloneOf|imgt:mAb_111 obo:NCIT_C128799|rdfs:subClassOf|obo:NCIT_C1909 imgt:Ono_Pharmaceuticals_Co_Ltd|rdf:type|obo:NCIT_C54131 imgt:BioInvent|rdfs:label|BioInvent imgt:StudyProduct_8a84372d-24b7-33d8-9f94-7a6a1fe6782b|imgt:hasClinicalPhase|imgt:Phase_II imgt:mAb_1193|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=1193 imgt:Clone_27|obo:RO_0002162|imgt:Musmus imgt:Segment_80_1|obo:BFO_0000050|imgt:Construct_80 imgt:PGF|rdfs:label|PGF imgt:IgG1-nd_435|imgt:isMabReceptorOf|imgt:mAb_435 imgt:mAb_1003|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=1003 imgt:mAb_632|imgt:inn_proposed_list|117 (2017) imgt:Product_285bd500-f170-3f00-920a-d6ab36e76e9a|imgt:hasStudyProduct|imgt:StudyProduct_f53e30ea-a3de-35af-974e-1cfe117d9fce imgt:Bostau_FSHR|skos:definition|Bostau FSHR (follicle stimulating hormone receptor) imgt:Segment_290_1|rdf:type|imgt:Segment imgt:Construct_1173|rdf:type|imgt:Construct imgt:StudyProduct_901a93fd-4460-3779-a192-04d20bf627bb|imgt:hasClinicalPhase|imgt:Phase_I/II imgt:Construct_948|rdfs:label|Construct_948 imgt:mAb_74|imgt:hasMabReceptor|imgt:MAbReceptor_74 imgt:IgG1-nd_55|rdfs:label|IgG1-nd_55 imgt:Product_d76084cc-0969-3c2e-96cd-515c35ac1758|imgt:hasStudyProduct|imgt:StudyProduct_a4b72b6a-53ce-3ee3-83c5-d44557866ec1 imgt:mAb_141|rdf:type|obo:NCIT_C1909 imgt:mAb_771|imgt:inn_name|zenocutuzumab imgt:Product_95f41e2a-be09-3c81-80de-1897a5986fef|rdfs:label|Product_95f41e2a-be09-3c81-80de-1897a5986fef imgt:F(ab%27)2-G1-kappa-PROT_906|imgt:hasMolecularComponent|imgt:IG imgt:StudyProduct_9b9bf253-4abd-3586-adc0-258764ae7a38|imgt:hasClinicalPhase|imgt:Phase_I/II imgt:StudyProduct_bd1cadae-bb8d-34d3-b194-3aa2a8a95dab|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_d0b9c36a-47a6-3ed4-963a-755e65fcf1c4|imgt:application_type|Therapeutic imgt:IG-Light-Lambda-IGL|imgt:defines|imgt:Fv-Heavy_Lambda imgt:IgG1-kappa_1035|rdfs:label|IgG1-kappa_1035 imgt:StudyProduct_d1e3b696-3c02-3d2b-88e8-b57f5a72c6df|imgt:hasClinicalIndication|imgt:Rheumatoid_arthritis_(RA) imgt:11597|imgt:isImgtStructureEntryOf|imgt:mAb_1150 imgt:Product_bec82608-56a6-34c7-8eb5-2ffa2f5406da|rdfs:label|Product_bec82608-56a6-34c7-8eb5-2ffa2f5406da imgt:Product_d9c0e462-7a45-30ba-bdd2-48dcf77e60dc|imgt:hasStudyProduct|imgt:StudyProduct_788c17fd-ae90-3f97-b8b8-0976786b20e7 imgt:IG-Heavy-Gamma-3-IGHG3|imgt:defines|imgt:F(ab’)2-Gamma-3_Lambda imgt:StudyProduct_385d9601-5136-3e78-b474-c2ad80ba4425|rdf:type|obo:NCIT_C174271 imgt:Product_da115066-6a6b-3fbc-83fe-48573602f57d|imgt:isProducedBy|imgt:Genmab_A/S imgt:mAb_112|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=112 imgt:StudyProduct_794808d5-60bc-384d-80e6-99686e844d7c|imgt:development_technology| Dyax human antibody phage display library imgt:StudyProduct_9f190a40-7b10-3eba-9bc2-9c3ad668abf1|imgt:development_technology| Abgenix's XenoMouse® _:Bc314c5dfd0beab5555267e909a1e84a7|imgt:isDecisionOf|imgt:StudyProduct_76ee9841-a655-331c-a8ef-8ffe48ebe5fc imgt:IgG4-lambda2_780|imgt:hasConstruct|imgt:Construct_780 imgt:StudyProduct_4a79c9a8-a58f-374e-8616-d854d046a585|rdfs:label|StudyProduct_4a79c9a8-a58f-374e-8616-d854d046a585 _:Ba5a9acf928dfc91ed06177aec20e1be3|dc:date|2010-01-08 _:B8b656adb3f8b5eae7873ec29349c61ee|imgt:isDecisionOf|imgt:StudyProduct_f8928c21-029a-311e-a5ae-b2505b18b929 imgt:Product_5c35ec7d-f892-34d7-a57f-2709a11d3612|rdf:type|obo:NCIT_C51980 imgt:IgG1-kappa_960|imgt:isMabReceptorOf|imgt:mAb_960 imgt:Product_33c97ddf-49a2-3444-885e-824d06bac68c|imgt:isProductOf|imgt:mAb_216 _:B7ce2850c3ac4b450e404dd4747c6bd8c|rdf:type|obo:NCIT_C53285 imgt:mAb_707|imgt:inn_name|insulin imgt:StudyProduct_88ac1799-ed28-3ed0-ba98-64ed71a84b83|rdfs:label|StudyProduct_88ac1799-ed28-3ed0-ba98-64ed71a84b83 imgt:mAb_1000|imgt:inn_name|alsevalimab imgt:StudyProduct_ec9edeaa-3a0d-3d75-9378-824aa1457d40|imgt:isStudyProductOf|imgt:Product_a99a661f-dfac-39f3-8f7d-abb5c67d65e2 imgt:StudyProduct_70af1ad9-fd1c-3cd9-90bd-29309d4e1b92|rdfs:label|StudyProduct_70af1ad9-fd1c-3cd9-90bd-29309d4e1b92 imgt:StudyProduct_d9103763-486b-34cf-8c35-e38f5b5cd090|imgt:isStudyProductOf|imgt:Product_c5655770-b6fa-3ca9-a0be-de4d35304022 imgt:Thromboembolic_diseases|imgt:clinical_domain|Cardiology imgt:StudyProduct_f8e070f0-9178-373d-9d81-ffb46c539e03|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_f8e070f0-9178-373d-9d81-ffb46c539e03|imgt:isStudyProductOf|imgt:Product_d6661c7d-81b0-3c2b-8328-9a7b5dfcae38 imgt:Product_84e76124-e7a6-3d53-bb0d-67db69ff6aa5|rdfs:label|Product_84e76124-e7a6-3d53-bb0d-67db69ff6aa5 imgt:StudyProduct_c9c9dc56-f803-3d24-984f-92c13838571c|imgt:hasDecision|_:B6262a01e127f92cce188edb49a63eff2 imgt:StudyProduct_dec3e93b-f8fd-3f69-8b0f-c893f2bf1763|imgt:application_type|Therapeutic imgt:mAb_321|rdf:type|obo:NCIT_C61070 imgt:StudyProduct_6b82f34f-3edd-3161-901d-a48e9eb3c856|rdf:type|obo:NCIT_C174271 imgt:EGF-1|rdf:type|imgt:IntegrinDomainLabel imgt:Sjögren's_syndrome_(SjS)|imgt:clinical_domain|Autoimmunity imgt:F(ab%27)2-nd-nd_14|http://semanticscience.org/resource/SIO_000291|imgt:ITGB2 imgt:Construct_335|rdfs:label|Construct_335 imgt:StudyProduct_87007e39-9ed3-3b6d-823a-59a1e99759cd|rdf:type|obo:NCIT_C174271 imgt:Product_3086b99e-8c37-3a44-8aaf-14e046e82b3b|imgt:hasStudyProduct|imgt:StudyProduct_976548a2-8826-3492-9d76-e971038eae5b imgt:mAb_665|imgt:hasImgtStructureEntry|imgt:10257 imgt:IgG2-kappa_2bridges_1261|rdfs:label|IgG2-kappa_2bridges_1261 imgt:FN1-6|rdfs:label|FN1-6 imgt:StudyProduct_80610928-6623-3030-a3d3-2a45b78f27bb|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:IgG1-kappa_MM_541|rdfs:comment|IgG1-kappa_MM imgt:Clone_252|imgt:isOriginCloneOf|imgt:mAb_252 imgt:Construct_895|obo:BFO_0000051|imgt:Segment_895_1 imgt:Schering-Plough|rdf:type|obo:NCIT_C54131 imgt:StudyProduct_1e3fba41-da07-3999-a7c1-baadbea6c956|rdfs:label|StudyProduct_1e3fba41-da07-3999-a7c1-baadbea6c956 imgt:mAb_1233|imgt:inn_number|11886 imgt:mAb_266|imgt:inn_proposed_list|89 (2003) imgt:Product_fab94625-4756-3e6a-befb-29a38260d15a|rdfs:label|Product_fab94625-4756-3e6a-befb-29a38260d15a imgt:IgG4-kappa_950|http://semanticscience.org/resource/SIO_000291|imgt:LAG3 imgt:StudyProduct_83022c95-c34d-302b-ac2f-5a4982727495|imgt:hasDecision|_:B43928fa05b54cee6e486f6066a501a0c imgt:Product_04ff78f3-f5e6-3084-a13e-fe88238ffe09|imgt:commun_name|MCLA-117 imgt:Mesothelioma_pleural_malignant|rdf:type|obo:NCIT_C185637 imgt:IL3RA|imgt:isTargetOf|imgt:IgG1-kappa_754 imgt:StudyProduct_dd7b4348-2917-3eed-a2c5-63ef8cfe5e6a|imgt:isStudyProductOf|imgt:Product_892634ba-c82f-36f9-9106-1537e1c79b28 imgt:StudyProduct_35b496e7-fefe-3df9-8267-b3e19da1e48f|imgt:hasDecision|_:B2aa5e70bea458177ac668e4faad61024 imgt:StudyProduct_24d90c1b-8a02-3108-862b-5a8e2f6ff5fc|rdf:type|obo:NCIT_C174271 imgt:mAb_1036|imgt:inn_proposed_list|122 (2019) imgt:Clone_357|rdf:type|obo:NCIT_C37925 imgt:Product_f1ec19af-7de9-3338-a0c4-5659cd375377|imgt:commun_name|hPAM4-DOTA imgt:AIDS-related_Kaposi's_sarcoma|imgt:isClinicalIndicationOf|imgt:StudyProduct_a5fee61c-61c3-387f-b88a-915bf034be05 imgt:Segment_451_1|rdf:type|imgt:Segment imgt:10904|rdf:type|obo:NCIT_C25402 imgt:Construct_352|obo:BFO_0000051|imgt:Segment_352_1 imgt:Product_18e218fa-ac0d-39a4-9e01-9513fbb2bc7c|imgt:commun_name|BIVV001 imgt:Hodgkin_lymphoma|imgt:isClinicalIndicationOf|imgt:StudyProduct_913d020b-28b5-3b7f-babc-1c4477d0ecfc imgt:11433|rdf:type|obo:NCIT_C25402 imgt:Segment_396_2|imgt:has_rank|2 imgt:StudyProduct_570b0f62-6343-325d-9344-8d8294daefd4|imgt:isStudyProductOf|imgt:Product_6b3150d9-5508-39df-a43d-348dac71bd4c imgt:mAb_963|imgt:hasImgtStructureEntry|imgt:10938 imgt:Segment_1194_1|obo:BFO_0000050|imgt:Construct_1194 imgt:mAb_407|imgt:hasImgtStructureEntry|imgt:9549 imgt:10558|rdf:type|obo:NCIT_C25402 imgt:Construct_139|rdfs:label|Construct_139 imgt:mAb_146|rdfs:label|mAb_146 imgt:StudyProduct_e76b895a-f38a-3b79-8863-09dba68b48d8|imgt:hasExpressionSystem|imgt:_CHO-S_(Chinese_Hamster_Ovary)_cells_suspension_culture imgt:Product_2617d7d5-76ab-3d60-b161-b32038696bd6|imgt:commun_name|PF-3446962 imgt:mAb_416|imgt:inn_name|duligotuzumab imgt:8448|imgt:isImgtStructureEntryOf|imgt:mAb_242 imgt:Product_bf6d0ac4-ff7a-36cb-8a46-33427568ee37|imgt:isProducedBy|imgt:AstraZeneca _:B7ebc41a6b98e28205c6bbbb2f8f6c680|imgt:isDecidedBy|imgt:FDA imgt:Product_fdbfc3ad-93cd-3a0a-bc28-d12d3fabe50a|imgt:commun_name|BH-2950 obo:NCIT_C166446|rdfs:subClassOf|obo:NCIT_C1909 imgt:IG-Heavy-Epsilon-IGHE|rdfs:label|IG-Heavy-Epsilon-IGHE imgt:Allergies_severe_ocular|imgt:clinical_domain|Immunology imgt:Segment_1082_1|rdfs:label|Segment_1082_1 imgt:StudyProduct_8fa0a452-5792-33e2-a012-f986e36e6fca|imgt:hasDecision|_:B4e563ee6e62edd906dcc0efd074701aa imgt:Clone_508|rdfs:label|Clone_508 imgt:StudyProduct_87fffe94-ae1a-3006-a8ee-be81eb91dd75|imgt:hasClinicalIndication|imgt:Cancers_ovarian imgt:Clone_867|rdf:type|obo:NCIT_C37925 _:B97c3ef969c6b306c07800b734dde316b|imgt:hasStatut|imgt:approval imgt:J-gene|skos:definition|Identifies, for gDNA, molecule entities with a germline J gene. 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imgt:mAb_1209|imgt:inn_name|teropavimab pubmed:1367535|dc:contributor|Bremner P. imgt:PROTEIN_BIG_TOXIN_BIG_732|imgt:hasMolecularComponent|imgt:CPCA imgt:Construct_1043|rdfs:label|Construct_1043 imgt:Segment_894_1|rdf:type|imgt:Segment imgt:IgG4-kappa_1015|imgt:isMabReceptorOf|imgt:mAb_1015 imgt:IgG1-kappa_194|obo:RO_0002162|imgt:Homsap imgt:mAb_1067|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=1067 imgt:11421|imgt:isImgtStructureEntryOf|imgt:mAb_1074 imgt:F7|imgt:isTargetOf|imgt:Fab-nd-nd_153 imgt:StudyProduct_30a720ac-7d77-31fb-963e-7075ddafc936|imgt:development_technology| Abgenix's XenoMouse® imgt:IgG1-nd-%5BPROTEIN%5D2_254|rdfs:comment|IgG1-nd-[PROTEIN]2 imgt:IgG1-kappa_761|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:IgG1-lambda-kappa(2)_1119|imgt:hasMolecularComponent|imgt:IG imgt:Segment_1079_1|rdf:type|imgt:Segment imgt:Cancers_breast_overexpressing_ERBB2_metastatic|imgt:isClinicalIndicationOf|imgt:StudyProduct_3405bca4-94e9-300a-9364-2b8815237935 imgt:pelmeg®|imgt:isBiosimilarOf|imgt:mAb_616 imgt:IGEngineeredLabel|skos:definition|Immunoglobulin engineered imgt:StudyProduct_93fa8b38-cc21-3fb3-a3d1-c26a79942eac|imgt:application_type|Therapeutic imgt:Product_02550586-7a1b-3018-bf60-0ad7c06c9f86|rdf:type|obo:NCIT_C51980 imgt:IG-Light-Kappa-IGKC|imgt:defines|imgt:F(ab’)2-Gamma-2-a_Kappa imgt:Product_6956a607-0f47-33a7-bdff-92b6edef93c2|imgt:commun_name|rFVIIIFc-VWF-XTEN imgt:Product_2b19c2f5-d596-3bcf-8b1b-86730cfcfc4b|imgt:hasStudyProduct|imgt:StudyProduct_1f3fc38a-852e-3414-a634-598255a47be7 imgt:StudyProduct_742c2b4e-d0c6-31a4-8553-8114c3e14529|imgt:hasClinicalIndication|imgt:Cancers imgt:mAb_655|rdfs:label|mAb_655 imgt:Product_ed1edad0-0dff-3bc0-86df-b902af890c2a|rdfs:label|Product_ed1edad0-0dff-3bc0-86df-b902af890c2a _:Be94718665d2921ee93156f126f0b8684|rdf:type|obo:NCIT_C53285 imgt:IL12B_(Pr122-232)|rdfs:label|IL12B (Pr122-232) imgt:mAb_349|rdfs:label|mAb_349 imgt:StudyProduct_735c0bc0-0411-315c-9537-87ebbfd1c806|imgt:hasClinicalPhase|imgt:Phase_I imgt:Product_1fc5752b-f7dc-3b64-af76-b622400cbd5f|rdfs:label|Product_1fc5752b-f7dc-3b64-af76-b622400cbd5f imgt:mAb_644|rdfs:label|mAb_644 imgt:DECAMER|rdf:type|imgt:RegulationLabel imgt:mAb_365|rdf:type|obo:NCIT_C79808 imgt:scFv-kappa-heavy-CD28_(CO-TM-CY)-CD247_827|http://semanticscience.org/resource/SIO_000291|imgt:CD19 imgt:StudyProduct_d141e5ff-8372-358a-8d88-fcc86d2244e0|rdfs:label|StudyProduct_d141e5ff-8372-358a-8d88-fcc86d2244e0 imgt:fibrin_II_beta_chain|imgt:isTargetOf|imgt:Fab%27-G1-kappa_131 imgt:3'D-NONAMER|rdfs:label|3'D-NONAMER imgt:Product_a1e50f83-c20d-35e3-9283-988f5a4850ad|rdfs:label|Product_a1e50f83-c20d-35e3-9283-988f5a4850ad _:B10bc87d1e68c38f1db281d50d3e999ab|imgt:hasStatut|imgt:approval _:Bbc004ecb8987cfea9a0c640dbaa5350e|imgt:isDecidedBy|imgt:FDA imgt:Product_be4ceb56-c2c1-3a7b-90f6-a24ff96b8e20|imgt:isProducedBy|imgt:MRC_Technology imgt:StudyProduct_4a15ef37-c104-3c66-be53-61f0924d6fb2|imgt:application_type|Therapeutic imgt:%5BVH-H-GAMMA-4_V-KAPPA-L-KAPPA%5D2|rdf:type|imgt:IGEngineeredLabel imgt:Product_711d76e7-b1b0-3c1e-b6b1-19c1df3bcad1|imgt:isProductOf|imgt:mAb_416 imgt:Segment_701_1|imgt:has_rank|1 imgt:Product_1df66a5a-21d1-3e20-92d6-5eaa918101c7|imgt:isProducedBy|imgt:Eli_Lilly imgt:StudyProduct_87df2003-d770-3cc3-88b8-b055ef490e3c|imgt:application_type|Therapeutic imgt:StudyProduct_02eab5fa-383c-309d-a7ae-08a64adc9956|imgt:isStudyProductOf|imgt:Product_d829c3cd-3223-3480-91af-ae2450ad4b2d imgt:Product_c5742b05-8a72-38fc-bf73-d7469ee38fbf|imgt:isProductOf|imgt:mAb_861 imgt:IgG4-kappa_241|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG4-kappa.png imgt:mAb_1142|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=1142 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imgt:Product_31d88f86-f890-3c06-9160-b268bfdcdad5|rdfs:label|Product_31d88f86-f890-3c06-9160-b268bfdcdad5 imgt:mAb_286|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=286 imgt:mAb_268|imgt:inn_proposed_list|89 (2003) imgt:FCRL5|skos:definition|FCRL5 (Fc receptor like 5, FCRH5, IRTA2, BXMAS1) imgt:Felcat_NGF|imgt:isTargetOf|imgt:IgG1-kappa_925 imgt:StudyProduct_aec72b5b-969b-3486-a11b-fe905a7ecdb7|imgt:hasClinicalPhase|imgt:Phase_II imgt:Construct_21|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Segment_583_1|rdf:type|imgt:Segment imgt:Product_fdbfc3ad-93cd-3a0a-bc28-d12d3fabe50a|imgt:commun_name|BH2950 _:B840b2cac76f60fe91f2bac693b0fd783|imgt:hasDesignation|imgt:Orphan_drug imgt:Segment_997_1|obo:BFO_0000050|imgt:Construct_997 _:B1ad98f8aac6d5c638161e7da144e19ab|rdf:type|obo:NCIT_C53285 imgt:mAb_477|imgt:hasImgtStructureEntry|imgt:9627 imgt:Clone_1167|rdfs:label|Clone_1167 imgt:Segment_1098_1|obo:BFO_0000050|imgt:Construct_1098 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imgt:Product_c67d4f68-56c4-3c24-8eaa-730b7fd45aaf|imgt:commun_name|JNJ-63733657 imgt:Construct_410|rdf:type|imgt:Construct imgt:mAb_646|rdfs:label|mAb_646 imgt:Cancers_prostate|imgt:isClinicalIndicationOf|imgt:StudyProduct_b063c60c-7c3d-3aac-92b4-c8661305b3be imgt:8653|rdf:type|obo:NCIT_C25402 imgt:StudyProduct_cf69c47f-5cad-39c6-a803-971560bf4b0d|imgt:hasClinicalPhase|imgt:Preclinical imgt:mAb_1254|imgt:inn_number|12003 imgt:Segment_704_2|rdf:type|imgt:Segment imgt:StudyProduct_7027cb45-d588-3eb7-b1c2-d35ec6045bee|imgt:hasDecision|_:B32b546605a004397d1839ab94d5b63c4 imgt:Product_dbe05b64-0640-322a-811c-7c37fcafe09b|imgt:hasStudyProduct|imgt:StudyProduct_9d1d9e74-0c74-3afb-b27e-f900f0034a60 imgt:StudyProduct_dc6809e6-c4ad-3782-9f75-308bff25ee20|rdfs:label|StudyProduct_dc6809e6-c4ad-3782-9f75-308bff25ee20 pubmed:7991583|imgt:isBibliographicReferenceOf|imgt:mAb_206 imgt:J-SEQUENCE|rdfs:label|J-SEQUENCE imgt:StudyProduct_a7e6a2e7-3932-3a92-9a59-238a750139d0|imgt:hasClinicalIndication|imgt:Solid_tumors imgt:mAb_909|imgt:hasImgtStructureEntry|imgt:10988 imgt:IgG1-kappa_560|obo:RO_0002162|imgt:Hum imgt:CH1|skos:definition|exon CH1 of IG heavy C-GENE in gDNA, or first C-DOMAIN of IG heavy chain in cDNA imgt:amjevita™|rdfs:label|AMJEVITA™ imgt:StudyProduct_345ef669-7c62-3f42-9cb3-e48a745498e0|rdf:type|obo:NCIT_C174271 imgt:hasEntry|rdfs:range|obo:GENO_0000722 imgt:IgG1-kappa_961|rdfs:comment|IgG1 - kappa imgt:Product_17ddf92e-c382-3c3c-b38b-fe0f24dae88d|imgt:commun_name|AGS-15E imgt:Construct_593|imgt:hasImgtLabel|imgt:IgG2-kappa-lambda imgt:StudyProduct_06f7f86b-9caf-3c74-88da-482672c16dbf|imgt:application_type|Therapeutic imgt:Fab%27-G1-kappa_596|imgt:isMabReceptorOf|imgt:mAb_596 imgt:StudyProduct_38804e2c-8020-32ad-8f9e-7e0a6981e8ab|imgt:application_type|Therapeutic imgt:mAb_1186|imgt:inn_recommended_list|87 (2022) imgt:PROTEIN_1DOMAIN_1050|rdfs:comment|PROTEIN_1DOMAIN imgt:mAb_245|imgt:inn_proposed_list|98 (2007) imgt:RemeGen_Ltd|rdfs:label|RemeGen, Ltd. imgt:StudyProduct_1488a7ea-5fe0-3ac3-a8a3-82aeca5bfbac|imgt:isStudyProductOf|imgt:Product_60d50ddc-7055-3124-936b-1628e2af1236 imgt:StudyProduct_788aba1c-003a-351a-94b2-fdb63d57c91e|imgt:application_type|Therapeutic imgt:mAb_771|rdf:type|imgt:INN imgt:StudyProduct_732c9358-8d39-3fa0-b48b-532b199af3bb|imgt:application_type|Therapeutic imgt:_BHK_cells_(ATCC_CCL_10)|imgt:isExpressionSystemOf|imgt:StudyProduct_a038f980-d395-3ef6-983a-e845316292be imgt:StudyProduct_f498a1e3-3991-390f-9004-c1d353f32e45|imgt:hasDecision|_:B0abc931c8896e5134b8db49be8b91976 _:B2450d3c61272c6c8d082c409ff72bdb8|imgt:isDecisionOf|imgt:StudyProduct_c02869ac-3e7f-384b-ade1-ea4d2187a1e8 imgt:Segment_650_1|imgt:has_rank|1 imgt:mAb_296|imgt:inn_name|robatumumab imgt:IgG2-kappa_538|rdfs:label|IgG2-kappa_538 imgt:StudyProduct_d7862a1c-b5f8-31f9-b5ff-c51bd8e6311c|imgt:hasClinicalPhase|imgt:Phase_III 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imgt:Clone_196|imgt:isOriginCloneOf|imgt:mAb_196 imgt:Product_0c4ce40c-4004-3873-ac20-3d6e604874e8|imgt:comercial_name|ALPROLIX® imgt:Progressive_supranuclear_palsy_(PSP)|imgt:isClinicalIndicationOf|imgt:StudyProduct_629d4aff-1483-3f88-bf03-a1d3ebc3a37e imgt:StudyProduct_5861d665-eb7e-3f6a-9693-10b825e40585|imgt:application_type|Therapeutic imgt:Clone_1215|rdf:type|obo:NCIT_C37925 pubmed:11567989|imgt:isBibliographicReferenceOf|imgt:mAb_112 imgt:IgG1-kappa-S239C_2cys-drug_904|imgt:hasMolecularComponent|imgt:IG imgt:StudyProduct_07c2f5c9-d098-3e2a-aeda-aface4f5a09a|imgt:hasClinicalIndication|imgt:Adult_eosinophilic_asthma imgt:Segment_554_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:IgG4-kappa_962|http://semanticscience.org/resource/SIO_000291|imgt:bispecific imgt:Clone_1141|imgt:clone_name|31C4 imgt:GCG|rdf:type|imgt:RPILabel imgt:StudyProduct_823c31f0-c5d8-3976-9843-0963a819e426|imgt:hasClinicalPhase|imgt:Phase_II 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imgt:mAb_52|imgt:hasProduct|imgt:Product_2de293bd-1023-3307-9fbd-5af2cf15c7e6 imgt:StudyProduct_000fefbd-8616-3e3d-aa5c-29ce1a6e2aad|imgt:application_type|Therapeutic imgt:StudyProduct_990d9537-fad6-3727-a623-6279efbdf49a|rdfs:label|StudyProduct_990d9537-fad6-3727-a623-6279efbdf49a imgt:Construct_775|rdf:type|imgt:Construct _:B13512b84187cc4739c22846e96457296|imgt:isDecidedBy|imgt:FDA imgt:Clone_1001|rdf:type|obo:NCIT_C37925 imgt:mAb_295|imgt:inn_name|ramucirumab imgt:mAb_148|rdf:type|obo:NCIT_C52186 imgt:Product_4dc025d9-1a02-3974-9131-37a906a286fa|imgt:commun_name|MEDI6469 imgt:TFRC|obo:RO_0002162|imgt:Homsap imgt:IgG1-lambda_792|http://semanticscience.org/resource/SIO_000291|imgt:CD70 imgt:IgG2-kappa_1170|rdf:type|imgt:MAbReceptor imgt:StudyProduct_e50d4ed9-46fe-35cb-8f6d-3c285717fee2|imgt:hasDecision|_:Bd60495b8d114f1336f51bd29cf958395 imgt:StudyProduct_3bedfdbd-9d24-3de1-9398-b8e83b752b51|imgt:development_technology| Chimeric antigen receptor (CAR) T cell engineering 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imgt:Cancers_colorectal_(CRC)|imgt:isClinicalIndicationOf|imgt:StudyProduct_55146c27-621e-353f-a87d-430a39e8e3e8 imgt:mAb_457|imgt:hasImgtStructureEntry|imgt:9713 imgt:Scleroderma|imgt:clinical_domain|Immunology imgt:StudyProduct_75dc4e56-f274-3fc3-8e16-9ebe8ace02b2|imgt:hasClinicalPhase|imgt:Phase_M imgt:CDR3|rdf:type|imgt:OldLabel imgt:StudyProduct_bb826a96-50b2-374c-8452-41846bbc3f98|imgt:isStudyProductOf|imgt:Product_7059201d-e2a8-3adc-9d1e-93b8e0e1285d imgt:%5BVH-CH1-VH-C-KAPPA-CH2-CH3(_L-KAPPA)_V-LAMBDA-CH1%5D_%5BH-GAMMA1_L-KAPPA%5D_795|http://semanticscience.org/resource/SIO_000291|imgt:bispecific imgt:StudyProduct_f46daee3-70a0-3629-8853-470a04aad715|imgt:hasClinicalPhase|imgt:Phase_III imgt:StudyProduct_bb826a96-50b2-374c-8452-41846bbc3f98|imgt:hasClinicalPhase|imgt:Phase_I imgt:IgG4-lambda_1031|rdfs:label|IgG4-lambda_1031 obo:NCIT_C155879|rdf:type|owl:Class imgt:Construct_561|imgt:isConstructOf|imgt:IgG2-kappa_561 imgt:Construct_1176|imgt:isConstructOf|imgt:IgG1-kappa_1176 obo:NCIT_C62179|rdfs:subClassOf|obo:NCIT_C1909 imgt:9235|rdfs:label|9235 imgt:Construct_1053|rdf:type|imgt:Construct pubmed:8097341|dc:contributor|Haug CE imgt:Construct_492|imgt:hasImgtLabel|imgt:IgG2-lambda imgt:Non-Hodgkin's_lymphoma_(NHL)|imgt:isClinicalIndicationOf|imgt:StudyProduct_ec70a093-6d3c-35c5-be2c-98a08bf4c33a imgt:StudyProduct_73f5f5ca-2a3d-37b5-8182-03eec8cde324|imgt:application_type|Therapeutic imgt:StudyProduct_f4519ce4-aa6b-3730-8911-9251055bc0be|imgt:hasClinicalPhase|imgt:Phase_I/II imgt:StudyProduct_c7137ab6-4e1f-3dda-8263-686958b19b19|imgt:hasClinicalPhase|imgt:Phase_I imgt:inn_proposed_list|rdfs:label|inn_proposed_list imgt:Construct_227|imgt:isConstructOf|imgt:IgG1-nd_227 imgt:mAb_1084|rdf:type|obo:NCIT_C1909 imgt:mAb_474|rdf:type|obo:NCIT_C166658 imgt:StudyProduct_b03c0e61-e11c-3a86-bf82-dbd54cd8549c|imgt:application_type|Therapeutic _:B99beaa92ec1285a5f38148d252b33c7a|rdf:type|obo:NCIT_C53285 imgt:Product_37f1c052-5249-3881-9f48-76440121e0dd|imgt:commun_name|SI-3106 imgt:Scotgen_Biopharmaceuticals_Ltd|imgt:produces|imgt:Product_b72d0fd8-0cf5-3f6d-ba1c-4cb49f256aa1 imgt:StudyProduct_40b274c9-cbce-3d0d-9e45-f57a914447eb|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:Product_f9431fba-428e-323c-9e21-0749755e9867|imgt:isProductOf|imgt:mAb_1184 imgt:IG-Heavy-Alpha|rdf:type|imgt:ChainType imgt:scFv-kappa-heavy-CD8A_(CO-TM)-TNFRSF9_(CY)-CD247_828|obo:RO_0002162|imgt:Chi imgt:Segment_1059_1|imgt:has_rank|1 imgt:StudyProduct_880048e4-140b-39df-8cc2-288ca967d860|imgt:isStudyProductOf|imgt:Product_7a63f972-9c9e-3455-92cd-81ee704c6884 imgt:mAb_1172|imgt:hasMabReceptor|imgt:IgG1-lambda_1172 imgt:Product_ad7c3645-09ab-3543-a583-4b655423ca16|imgt:isProductOf|imgt:mAb_325 imgt:Product_4a3e77b0-665b-30cc-8259-ed42deba2921|imgt:hasStudyProduct|imgt:StudyProduct_9eae6e66-7f22-3fb1-9cda-7d6c32e162fc imgt:StudyProduct_a803188d-b219-3817-8304-9b68c3f4e087|rdfs:label|StudyProduct_a803188d-b219-3817-8304-9b68c3f4e087 imgt:StudyProduct_e11efdd3-ff61-3f7d-bfdf-71a48aecb94f|imgt:application_type|Therapeutic imgt:Segment_711_1|imgt:has_rank|1 imgt:Product_1fc5752b-f7dc-3b64-af76-b622400cbd5f|imgt:isProductOf|imgt:mAb_264 imgt:IgG1-nd_MM_7|obo:RO_0002162|imgt:Musmus imgt:bispecific|skos:definition|bispecific imgt:IgG1-kappa_431|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:StudyProduct_840fc260-3eb1-31df-a157-7005ef62b2ae|imgt:hasClinicalIndication|imgt:Graft-versus-host_disease_(GvHD) imgt:Construct_977|obo:BFO_0000051|imgt:Segment_977_1 imgt:8693|rdf:type|obo:NCIT_C25402 obo:NCIT_C152172|rdf:type|owl:Class imgt:%5BICOSLG_(inducible_T-cell_co-stimulator_ligand_B7H2_B7-H2_ICOS-L_B7-related_protein_1_B7RP1_B7RP-1_B7_homolog_2_B7_homologue_2_GL50_KIAA0653_CD275)_N-terminal_fragment_(1-122)%5D2-IGHG1_Fc_(Fragment_constant)|imgt:construction_detail|Fusion - [ICOSLG (inducible T-cell co-stimulator ligand, B7H2, B7-H2, ICOS-L, B7-related protein 1, B7RP1, B7RP-1, B7 homolog 2, B7 homologue 2, GL50, KIAA0653, CD275) N-terminal fragment (1-122)]2 - IGHG1 Fc (Fragment constant) imgt:Inflammatory_conditions_acute_and_chronic|rdfs:label|Inflammatory_conditions_acute_and_chronic imgt:Product_c42c3c26-2cfd-36ea-9d59-76a604b6b704|imgt:isProducedBy|imgt:Genmab_A/S imgt:Product_2be3ac92-206e-3913-a568-7aff3f809d0d|rdfs:label|Product_2be3ac92-206e-3913-a568-7aff3f809d0d imgt:StudyProduct_a1894a79-2e9b-3344-a488-c121627450a0|imgt:hasDecision|_:Bc55f4d7b1c69d8c8030e2f2c034cadad imgt:StudyProduct_8fbe27b0-9f2d-3db9-9003-bb0408a6f289|rdfs:label|StudyProduct_8fbe27b0-9f2d-3db9-9003-bb0408a6f289 imgt:Construct_20|obo:BFO_0000051|imgt:Segment_20_1 imgt:Product_a88f085a-e137-3444-9a20-261605447b86|rdfs:label|Product_a88f085a-e137-3444-9a20-261605447b86 imgt:mAb_979|rdf:type|obo:NCIT_C171844 imgt:Product_5dea998c-cfea-32c4-a7bd-01fd1839b7c7|imgt:commun_name|PF-06741086 imgt:Product_a40b72fa-6beb-3dea-9182-268887df521d|rdfs:label|Product_a40b72fa-6beb-3dea-9182-268887df521d imgt:MacroGenics_Inc|imgt:produces|imgt:Product_27f3c39d-c940-36e9-b77b-b5638fb484c9 imgt:StudyProduct_165a82e1-b3b3-3d74-8e9b-63f471a1f450|imgt:hasDecision|_:B54502329a7281b700e04b1024a9c093c imgt:StudyProduct_a1c85df1-9a7e-3cbb-8c9e-a8bcb6aaadd5|rdf:type|obo:NCIT_C174271 imgt:mAb_1077|imgt:inn_recommended_list|85 (2021) imgt:StudyProduct_3a112820-24e5-38b4-b74d-fed953863cdc|imgt:hasExpressionSystem|imgt:_CHOK1SV_(expresses_glutamine_synthetase_(GS)_endogenously)_cells imgt:mAb_28|imgt:hasOriginClone|imgt:Clone_28 imgt:Product_18dc50b9-4d8b-3250-ab3a-3303c63eafcb|rdfs:label|Product_18dc50b9-4d8b-3250-ab3a-3303c63eafcb imgt:CD52|skos:definition|CD52 imgt:Product_4b769096-e5f9-3d05-b824-bd6eba506323|imgt:isProductOf|imgt:mAb_423 _:B23841aa4e82d3379c618367e5c638767|imgt:hasDesignation|imgt:Orphan_drug imgt:Product_7e295705-2be2-3155-abb4-bbd44acfd06b|rdf:type|obo:NCIT_C51980 imgt:IgG1-kappa_813|http://semanticscience.org/resource/SIO_000291|imgt:AXL imgt:KIRD2_subgroup|obo:RO_0002162|imgt:Homsap imgt:IgG4-kappa_809|imgt:hasConstruct|imgt:Construct_809 imgt:Product_d94907bf-4e03-3fa2-b966-fc5265718562|rdf:type|obo:NCIT_C51980 obo:GENO_0000413|rdfs:label|hasAllele imgt:Clone_235|rdf:type|obo:NCIT_C37925 imgt:Construct_218|rdf:type|imgt:Construct imgt:StudyProduct_f5830fbe-63ca-3d3f-999b-81b658186793|imgt:application_type|Therapeutic imgt:bivalent|imgt:isTargetOf|imgt:VH-VH%27_1014 imgt:IgG4-kappa_957|imgt:hasMolecularComponent|imgt:IG imgt:mAb_261|imgt:hasProduct|imgt:Product_ed8a74ee-19be-3e61-b1da-90ff79b0637d _:B54ba76f45c209d42e8ee61bc84aaa3b1|imgt:isDecidedBy|imgt:EMA imgt:Clone_88|imgt:isOriginCloneOf|imgt:mAb_88 imgt:StudyProduct_d64333ec-cf02-36ce-82e7-e744a8d3d307|imgt:hasClinicalIndication|imgt:Idiopathic_thrombocytopenic_purpura pubmed:9140729|dc:date|1996 imgt:Product_eaa50595-7c42-33fb-a33a-988a28daf176|rdfs:label|Product_eaa50595-7c42-33fb-a33a-988a28daf176 imgt:mAb_469|imgt:hasProduct|imgt:Product_77251cf3-dc70-36b8-b2f0-5ab289f17bc9 imgt:Product_be72163f-78a5-3a36-89d3-87e234fb9f7b|rdf:type|obo:NCIT_C51980 imgt:mAb_75|imgt:hasProduct|imgt:Product_07a0f8df-d456-3179-a3a2-ab802e7d3e13 imgt:ENZ-CTP_698|rdfs:label|ENZ-CTP_698 imgt:Cancers_gastric|imgt:clinical_domain|Oncology imgt:11173|rdfs:label|11173 imgt:Product_bf813acf-a5a5-3c97-95c6-5809bda944e1|imgt:isProductOf|imgt:mAb_1182 imgt:mAb_1282|imgt:hasImgtStructureEntry|imgt:11909 _:Bc650f687496c77e4d9ee16c1de3903c8|imgt:isDecisionOf|imgt:StudyProduct_57a8b408-a3da-3c62-a3f2-c90f8f441843 _:Bcbaad141d89b883004104388c819a717|dc:date|2008-02-22 imgt:mAb_212|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=212 imgt:StudyProduct_114bfc0c-1fcf-3f53-b88a-6ee6f0c72428|imgt:application_type|Therapeutic imgt:Segment_762_1|rdf:type|imgt:Segment obo:NCIT_C174929|rdfs:subClassOf|obo:NCIT_C1909 imgt:mAb_534|rdf:type|obo:NCIT_C101895 imgt:Construct_71|imgt:isConstructOf|imgt:IgG1-kappa_71 imgt:heat_shock_protein_90_homolog|rdfs:label|heat shock protein 90 homolog imgt:mAb_79|imgt:hasMabReceptor|imgt:IgG1-kappa_79 imgt:EX2T|rdf:type|imgt:C-RegionExonLabel imgt:mAb_106|rdf:type|obo:NCIT_C152236 imgt:VH-C-kappa-CH2-CH3_V-lambda-CH1_H-GAMMA-1_L-kappa_793|obo:RO_0002162|imgt:Homsap imgt:mAb_395|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=395 imgt:Product_d34f1ebd-acfa-3151-b703-7247bec7bb83|imgt:hasStudyProduct|imgt:StudyProduct_f2c33795-07dd-383e-98dc-a816a4d6062f imgt:Valeant_Pharmaceuticals_International_Inc|rdfs:comment|Laval , Canada imgt:Product_e92a1f6b-b0a8-3d24-915b-82fcb6694c39|imgt:isProductOf|imgt:mAb_152 imgt:Hypereosinophilic_syndrome_(HES)|rdfs:label|Hypereosinophilic_syndrome_(HES) imgt:Rheumatoid_arthritis_(RA)|imgt:isClinicalIndicationOf|imgt:StudyProduct_32c61a15-2c8b-3f79-bbad-89bdad015cc7 imgt:FGFR4|rdf:type|obo:NCIT_C25702 imgt:mAb_128|imgt:hasOriginClone|imgt:Clone_128 imgt:Clone_1174|imgt:isOriginCloneOf|imgt:mAb_1174 imgt:Product_804344aa-9846-368c-b3c2-764390d1bcc8|imgt:hasStudyProduct|imgt:StudyProduct_f74c0406-a8cf-360b-a0e5-687f8ccd98cd imgt:mAb_713|imgt:inn_recommended_list|78 (2017) obo:NCIT_C2658|rdfs:subClassOf|obo:NCIT_C1909 _:B08d5f0c8287cbdf582daf2e5d69d9554|rdf:type|obo:NCIT_C53285 imgt:Construct_907|obo:BFO_0000051|imgt:Segment_907_1 imgt:Segment_571_1|imgt:has_rank|1 imgt:mAb_367|rdf:type|imgt:INN imgt:StudyProduct_da5ccc3d-ad58-3594-8f96-7cc55262d8fc|imgt:hasClinicalIndication|imgt:Cancers imgt:StudyProduct_c959e43a-2545-3a0e-a9d2-28ecca63ff2a|imgt:isStudyProductOf|imgt:Product_bebc2f14-8f71-3ea6-8a19-cbba5d49a3c8 imgt:Product_6904ec1c-c8e9-3f52-a5cf-64b44b46bc2d|rdfs:label|Product_6904ec1c-c8e9-3f52-a5cf-64b44b46bc2d imgt:StudyProduct_85da48ac-fe22-3b3d-8f2b-9949bbfef548|rdfs:label|StudyProduct_85da48ac-fe22-3b3d-8f2b-9949bbfef548 imgt:Product_16f344fd-3b77-3409-a0be-a0781c08856c|rdf:type|obo:NCIT_C51980 imgt:StudyProduct_f55e0ab5-a277-3480-81b4-9981b86c5f54|imgt:isStudyProductOf|imgt:Product_b72d0fd8-0cf5-3f6d-ba1c-4cb49f256aa1 imgt:mAb_606|imgt:inn_proposed_list|114 (2015) imgt:Clone_226|rdfs:label|Clone_226 imgt:SCFV-DELTA-GAMMA|rdfs:label|SCFV-DELTA-GAMMA imgt:Chugai_Pharmaceutical_Co_Ltd|imgt:produces|imgt:Product_23845aab-eacf-316c-b614-80fa65b8d2cd imgt:IgG1-kappa-4cys-drug4_1278|imgt:conjugated_with| analogue of motolimod (an agonist for the toll-like receptor 8, TLR8) imgt:Lombar_radicular_pain|rdfs:label|Lombar_radicular_pain imgt:mAb_668|imgt:hasImgtStructureEntry|imgt:10273 imgt:Construct_1120|imgt:isConstructOf|imgt:IgG1-kappa_1120 imgt:StudyProduct_d790e869-4e7c-36d6-bac0-07c0818036ec|imgt:isStudyProductOf|imgt:Product_2d7e77c3-d14e-30b0-9aab-5d03bcd3b872 imgt:StudyProduct_45bb821b-369c-31a4-bd72-4bb41b86a986|imgt:isStudyProductOf|imgt:Product_68ba4461-b5a0-3c71-bc9b-64306af5f891 imgt:IgG1-kappa_360|imgt:hasConstruct|imgt:Construct_360 imgt:StudyProduct_9b52f642-d4b7-3cc8-93f2-281f15bb283c|imgt:application_type|Therapeutic imgt:VH-CH1-VH-C-KAPPA-CH2-CH3_V-LAMBDA-CH1_GAMMA-1_KAPPA|rdf:type|imgt:IGEngineeredLabel _:B6a79c6f0bc2fb1962abdfec6240a1584|imgt:isDecidedBy|imgt:FDA imgt:Product_d688aa3b-aa3d-3d8e-9f4f-2f22e5a667f9|imgt:isProductOf|imgt:mAb_1062 imgt:mAb_745|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=745 imgt:IG-GAMMA-2_LAMBDA|rdf:type|imgt:StructureLabels imgt:F(ab’)2-Gamma-4_Kappa|rdfs:label|F(ab’)2-Gamma-4_Kappa imgt:11267|rdfs:label|11267 imgt:Construct_880|imgt:hasImgtLabel|imgt:IgG-nd imgt:Segment_576_1|imgt:has_rank|1 imgt:mAb_898|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=898 imgt:IgG2-kappa_249|http://semanticscience.org/resource/SIO_000291|imgt:TNFSF11 imgt:IgG4-kappa_375|obo:RO_0002162|imgt:Hum imgt:mAb_911|imgt:hasProduct|imgt:Product_b0d0c09a-7196-3fc5-8676-4db70c57ba7c imgt:mAb_227|rdfs:label|mAb_227 imgt:J-GENE|rdf:type|imgt:PrototypeLabel imgt:StudyProduct_f96588b4-d3c1-35cb-b6d7-f2867a3f3bbe|imgt:isStudyProductOf|imgt:Product_3adee3e6-6ae0-336d-9a0a-2290f3ed968a imgt:IgG1-nd_439|http://semanticscience.org/resource/SIO_000291|imgt:Severe_acute_respiratory_syndrome_coronavirus_(SARS-CoV) _:Bf9aca44de51070d9583b06053e38df92|imgt:hasDesignation|imgt:Orphan_drug imgt:IgG1-kappa_223|http://semanticscience.org/resource/SIO_000291|imgt:APP imgt:half-IG_G1-kappa/(scFv-kappa-heavy)-h-CH2-CH3|rdfs:label|half-IG G1 - kappa / (scFv - kappa - heavy) -h-CH2-CH3 imgt:C-LAMBDA|rdf:type|imgt:C-DomainLabel imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_44315cfa-b923-3486-b0f2-03ffdd0d2a9f imgt:mAb_1076|rdf:type|obo:NCIT_C177097 imgt:CARRIER_BIG-8PEPTIDE_398|imgt:conjugated_with| cridificar : diphteria toxin mutant CRM197 (vaccine carrier) via a Cys-S-CH2-CO- linker imgt:IgG2-kappa_2bridges_1261|obo:RO_0002162|imgt:Can imgt:Influenza_A_infection|imgt:isClinicalIndicationOf|imgt:StudyProduct_56d88cd4-2915-3f42-bd78-e9ea39318671 imgt:Product_410df2c2-31fc-38b5-a007-2574a4c85dde|imgt:isProducedBy|imgt:Cubist_Pharmaceuticals_Inc imgt:StudyProduct_dcba4409-14f2-34be-b16e-a35978b32e15|rdf:type|obo:NCIT_C174271 imgt:mAb_1196|imgt:hasProduct|imgt:Product_747d2bfa-44b6-3feb-95ae-81e3134044b6 imgt:Product_2890017a-13c6-3886-aebb-4d04a806965e|imgt:isProducedBy|imgt:National_Institute_Allergy_Infectious_Diseases_(NIAID) imgt:StudyProduct_4f49afd7-292a-34b7-bc35-bdfc3ab50fc7|imgt:hasClinicalIndication|imgt:Cancers_fallopian_tube imgt:Segment_30_1|rdfs:label|Segment_30_1 imgt:Construct_280|imgt:hasImgtLabel|imgt:IgG1-nd imgt:Product_cbd0baaf-87ab-3efd-87a0-619e0f9667a5|imgt:commun_name|F7a-ALB imgt:Construct_579|obo:BFO_0000051|imgt:Segment_579_1 imgt:abrilada™|rdfs:comment| ABRILADA™ (adalimumab-afzb) developed by Pfizer (New York NY USA) approved by FDA on November 15 2019. (BLA) 761118 Same clinical indications as HUMIRA®. imgt:Product_6749bce5-ca17-3a1e-b6a6-716da8fc041b|imgt:isProducedBy|imgt:Genmab_A/S imgt:OSMR|skos:definition|OSMR (oncostatin M receptor, OSMRB, OSMRbeta) imgt:Segment_1099_1|imgt:has_rank|1 imgt:Segment_692_2|rdfs:label|Segment_692_2 imgt:StudyProduct_85da48ac-fe22-3b3d-8f2b-9949bbfef548|rdf:type|obo:NCIT_C174271 imgt:PROTEIN_BIG_TOXIN_BIG_732|rdfs:comment|PROTEIN_BIG_TOXIN_BIG imgt:Neoplasms|imgt:clinical_domain|Oncology pubmed:1813210|dc:contributor|Saunders JA imgt:mAb_706|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=706 imgt:OBTENTION|rdfs:label|OBTENTION imgt:mAb_375|imgt:hasProduct|imgt:Product_df7aa59a-c953-3d7c-aae2-38c9ce0095f4 imgt:Segment_692_1|obo:BFO_0000050|imgt:Construct_692 imgt:Segment_430_1|imgt:has_rank|1 imgt:Lombar_radicular_pain|rdf:type|obo:NCIT_C185637 imgt:FC-%5BPEPTIDE-PEPTIDE%5D2_393|http://semanticscience.org/resource/SIO_000291|imgt:MPL imgt:Segment_540_1|imgt:has_rank|1 imgt:3'D-NONAMER|rdf:type|imgt:NonamerLabel imgt:StudyProduct_ceb873d1-dc26-35e6-ba29-202f1ea45e3b|rdfs:label|StudyProduct_ceb873d1-dc26-35e6-ba29-202f1ea45e3b imgt:StudyProduct_2d05efe7-5286-304e-b7ab-f9b4a8c4e937|imgt:application_type|Therapeutic imgt:Product_93b7132b-5be4-3248-9d55-bb48290a5de1|imgt:isProductOf|imgt:mAb_879 imgt:IgG1-kappa-4cys-drug_482|imgt:isMabReceptorOf|imgt:mAb_482 imgt:Product_0c9f5d50-b81e-3ee8-93bc-e8be40fcc398|rdf:type|obo:NCIT_C51980 imgt:StudyProduct_4ff3791f-430a-396c-b7dc-38fd60a2e83a|rdf:type|obo:NCIT_C174271 imgt:TNFRSF8|skos:definition|TNFRSF8 (tumor necrosis factor receptor (TNFR) superfamily member 8, KI-1, CD30) imgt:StudyProduct_fe4cfbeb-d0d6-35d8-b5c5-a9be61e63041|imgt:isStudyProductOf|imgt:Product_b2072ae4-eefb-349e-8d86-917940ef0bb3 imgt:StudyProduct_fd29fe6c-dc18-3851-a09b-b0e6a16e6e45|imgt:development_technology| Cambridge Antibody Technology (CAT) human antibody phage display library imgt:8832|rdf:type|obo:NCIT_C25402 imgt:mAb_916|imgt:hasMabReceptor|imgt:IgG4-kappa_916 imgt:Product_d3b3ee2c-a59b-36a5-a62a-c351fa3e366e|rdfs:label|Product_d3b3ee2c-a59b-36a5-a62a-c351fa3e366e imgt:Segment_5_1|rdfs:label|Segment_5_1 obo:NCIT_C170906|rdfs:subClassOf|obo:NCIT_C1909 imgt:mAb_408|imgt:hasProduct|imgt:Product_75a2ea16-7c01-33b5-99ec-50f47304f68d imgt:chicken_lysosyme|obo:RO_0002162|imgt:Galgal imgt:IgG2-kappa_249|rdf:type|imgt:MAbReceptor imgt:StudyProduct_06f7f86b-9caf-3c74-88da-482672c16dbf|rdfs:label|StudyProduct_06f7f86b-9caf-3c74-88da-482672c16dbf imgt:StudyProduct_9b10453f-0712-3496-ae6f-71002f8c38bb|imgt:hasDecision|_:B12bfedd4c7a6ff56170de1cee88c8cc5 imgt:StudyProduct_14827a6a-a4ac-3723-b51f-22dea68d060e|rdfs:label|StudyProduct_14827a6a-a4ac-3723-b51f-22dea68d060e imgt:Product_e92a1f6b-b0a8-3d24-915b-82fcb6694c39|imgt:isProducedBy|imgt:GlaxoSmithKline imgt:StudyProduct_3cf885c8-c7b2-3a9b-b637-6fadb2324fb9|imgt:hasClinicalIndication|imgt:Stroke imgt:Zoetis|rdfs:label|Zoetis imgt:mAb_918|imgt:inn_recommended_list|82 (2019) imgt:IgG4-kappa-%5BscFv%5D2_776|imgt:hasConstruct|imgt:Construct_776 imgt:Cancers_blood|rdfs:label|Cancers_blood imgt:Product_3240bd63-d353-315d-9029-d61ff35ab692|imgt:comercial_name|REMOVAB® imgt:StudyProduct_1932e31c-ebfe-371f-90bc-94871b025a4b|imgt:isStudyProductOf|imgt:Product_5fe90c16-d2de-3542-bba6-f7634ec51c07 _:B6b5c24242167703262af7fb8bd914a16|imgt:isDecidedBy|imgt:FDA imgt:CPCA_PROTEIN-FC_820|rdfs:comment|CPCA_PROTEIN-FC imgt:Non-Hodgkin's_lymphoma_(NHL)|imgt:isClinicalIndicationOf|imgt:StudyProduct_c905f749-92b7-35ce-8e77-1bb48e3bca6a imgt:IgG1-lambda_1219|imgt:isMabReceptorOf|imgt:mAb_1219 imgt:Acute_myocardial_infarction|imgt:isClinicalIndicationOf|imgt:StudyProduct_53183842-71ef-3bbc-a045-3c4e63aa385f imgt:Ono_Pharmaceuticals_Co_Ltd|rdfs:comment|Osaka , Japan imgt:Segment_151_1|rdfs:label|Segment_151_1 imgt:Product_d1ff3524-abf9-3a7a-93d3-8b514c80da83|imgt:commun_name|IFNA2 R23 imgt:StudyProduct_9fb25145-bfe7-33f6-9117-a8a9ca677ff6|rdf:type|obo:NCIT_C174271 imgt:Segment_575_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:StudyProduct_e7755a61-bc17-385d-8e2e-53e84a96dc04|imgt:isStudyProductOf|imgt:Product_95973100-5a45-3d50-9924-c8932582e63b imgt:11133|imgt:isImgtStructureEntryOf|imgt:mAb_956 imgt:Transplantation|imgt:isClinicalIndicationOf|imgt:StudyProduct_e98c2bee-e41e-31b4-bedf-7b531366ad96 imgt:ganglioside_N-glycolyl_GM3|imgt:isTargetOf|imgt:IgG1-kappa_MM_108 imgt:Construct_382|rdf:type|imgt:Construct imgt:Clone_1237|rdfs:label|Clone_1237 imgt:mAb_368|imgt:inn_recommended_list|66 (2011) imgt:StudyProduct_99e9dc7c-7bd4-3b09-9fe5-56caee4039e2|imgt:hasDecision|_:B690ba0ce00923397d0089d050118b36c imgt:mAb_510|imgt:hasMabReceptor|imgt:MAbReceptor_510 imgt:StudyProduct_6ffca9d6-47be-3885-833e-fc7f8d57c423|imgt:hasClinicalPhase|imgt:Phase_M imgt:Construct_350|rdfs:label|Construct_350 imgt:Clone_1286|imgt:clone_name|A-beta mAb31hTfR BBB-1026 imgt:Construct_473|rdf:type|imgt:Construct imgt:mAb_149|imgt:hasImgtStructureEntry|imgt:8734 imgt:StudyProduct_3593e4ce-f227-33e4-a62d-662cc6212276|imgt:isStudyProductOf|imgt:Product_2f33022b-bbc0-3f59-bc75-86deb8919d2c imgt:Asthma_severe_persistent|imgt:isClinicalIndicationOf|imgt:StudyProduct_5103d28f-4657-32c4-8d25-5305c9f99bce imgt:StudyProduct_c44937d5-47d6-3303-a118-7b724d88dc14|rdf:type|obo:NCIT_C174271 imgt:Construct_1047|imgt:isConstructOf|imgt:ENZ_1DOMAIN_1047 _:B93283afd87fb80f70128d8487d481ba5|imgt:isDecidedBy|imgt:FDA imgt:StudyProduct_5cf0c516-2972-37f2-ab70-2c2d6e4acfc6|imgt:hasClinicalPhase|imgt:Phase_I _:B9fbc0aee9b03c91f0d9e484b9f3b4363|imgt:isDecisionOf|imgt:StudyProduct_4be745c4-3084-3be0-bc46-8406ddd707b1 imgt:StudyProduct_48088129-f77a-30bd-b1af-d861ec4ac8bf|imgt:application_type|Therapeutic imgt:Product_616f015a-2ec9-334a-933d-d673091d2b9e|imgt:hasStudyProduct|imgt:StudyProduct_685eb30b-6447-3724-aa29-186322adbbab imgt:Carcinoma_esophageal|imgt:isClinicalIndicationOf|imgt:StudyProduct_8dcdbc19-94fa-3962-86c1-8bf267c075df imgt:MH2|imgt:isDefinedBy|imgt:MH2-Alpha imgt:Product_1888d397-b8cb-3822-a596-eae642392bfc|imgt:isProductOf|imgt:mAb_571 imgt:StudyProduct_71b75379-eb4c-3f15-b0fc-beda141a12a8|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_08f5e779-ba8f-3f4a-a6c5-8c761d1fcfb9|imgt:hasDecision|_:Bf72210ff4eb973224f03e2728a31bfba imgt:Product_824a35bb-e1eb-3559-99fa-ab9a1858d010|imgt:hasStudyProduct|imgt:StudyProduct_5a5c7b16-1104-3817-8817-64e9caa4b33b imgt:Construct_546|obo:BFO_0000051|imgt:Segment_546_1 imgt:PROTEIN_1DOMAIN_1050|imgt:isMabReceptorOf|imgt:mAb_1050 imgt:APEIRON_Biologics_AG|imgt:produces|imgt:Product_73163992-bca3-3133-8e3d-bb21f7359d0d imgt:StudyProduct_232b48c8-5c3f-38af-9a24-d625cb31e8d9|imgt:isStudyProductOf|imgt:Product_b040dae5-3608-32e1-b3f2-9802ffb17c21 imgt:Product_c4281e8f-8be3-33d2-a3b5-de0eaf8f6d6d|rdf:type|obo:NCIT_C51980 imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_1e3d13d6-30e9-30d3-90c2-86212912f6e9 imgt:Segment_72_1|imgt:hasImgtLabel|imgt:IgG1-nd imgt:IL17A|imgt:isTargetOf|imgt:IgG1-kappa_326 imgt:F(AB%27)2-GAMMA-1_LAMBDA|rdfs:label|F(AB')2-GAMMA-1_LAMBDA imgt:PRIMER_BIND|rdfs:label|PRIMER_BIND _:Be241cf9c320810c49d2c4d198b87e1ac|imgt:isDecidedBy|imgt:FDA imgt:mAb_961|rdf:type|imgt:INN obo:NCIT_C166512|rdf:type|owl:Class imgt:mAb_968|rdf:type|obo:NCIT_C142168 imgt:mAb_97|imgt:hasImgtStructureEntry|imgt:7637 imgt:Waldenstrom's_macroglobulinemia|imgt:clinical_domain|Oncology imgt:Construct_462|imgt:hasImgtLabel|imgt:Fab-G1-kappa imgt:IgG1-kappa-2cys-drug_775|obo:RO_0002162|imgt:Homsap imgt:Cancers_non-small_cell_lung_(NSCLC)|imgt:isClinicalIndicationOf|imgt:StudyProduct_d147df3d-6f40-37d7-8fd3-247e6dcd509d _:B33aa435f17d3698de6858121cc66ad1c|imgt:isDecisionOf|imgt:StudyProduct_454fa2ab-d4ad-3680-9760-9da2d95eb36a imgt:IgG1-lambda-3lys-drug_471|imgt:conjugated_with| maytansinoid DM4 imgt:Segment_1084_1|imgt:has_rank|1 imgt:Product_508e2008-3ac6-3a20-8b85-3bae9bb94b1f|rdf:type|obo:NCIT_C51980 imgt:mAb_236|imgt:inn_proposed_list|99 (2008) imgt:isLocusLocationTypeOf|rdfs:range|imgt:Locus imgt:Product_c6e625a6-b97d-3e44-9c4f-6b949cd3d815|rdf:type|obo:NCIT_C51980 pubmed:18088084|dc:contributor|Pastan I imgt:6XDG|imgt:isImgtStructureEntryOf|imgt:mAb_1108 imgt:mAb_705|imgt:clinical_trials|356 studies found, 38 recruiting _:Bda17b9beaad0e3fb32ab299e21393306|dc:date|2014-12-16 imgt:StudyProduct_0bd97db3-603e-34a6-baf5-8b7e007d228a|imgt:isStudyProductOf|imgt:Product_c2cf8e9a-b6f0-3bef-989a-2dce59eae331 imgt:Product_b986b41d-7c9e-35e9-89a2-8bf0e574d823|rdfs:label|Product_b986b41d-7c9e-35e9-89a2-8bf0e574d823 imgt:PROTEIN_1DOMAIN_893|obo:RO_0002162|imgt:Homsap imgt:IgG2-kappa_954|http://semanticscience.org/resource/SIO_000291|imgt:TNFRSF4 imgt:StudyProduct_50c57a82-84df-34c5-bed8-09d115373427|imgt:hasClinicalPhase|imgt:Phase_III imgt:IgG1-lambda_1267|imgt:hasConstruct|imgt:Construct_1267 imgt:StudyProduct_d5c67ac7-981f-3c29-bfc0-5cb699da847b|imgt:hasClinicalIndication|imgt:Ebola_virus_infection imgt:StudyProduct_333df381-8e4d-3f9f-ad92-9e329e8a5721|imgt:isStudyProductOf|imgt:Product_7059201d-e2a8-3adc-9d1e-93b8e0e1285d imgt:StudyProduct_3b49444b-27d5-3009-9948-320cd9518ba7|imgt:application_type|Therapeutic _:B771c4f0fee882b45fad53e8f860235e1|imgt:isDecisionOf|imgt:StudyProduct_ff3ed28b-5382-3602-9a61-d06b879bf722 _:B3211eaeee2b00e7ee1df55fc7061fe32|dc:date|2019-08-08 imgt:True_North_Therapeutics|rdf:type|obo:NCIT_C54131 imgt:Factor_substitute|imgt:isTargetOf|imgt:ENZ-XTEN_700 imgt:scFv-kappa-heavy-scFv-kappa-heavy-CD4(CO-TM-CY)_1232|obo:RO_0002162|imgt:Chi imgt:mAb_1001|imgt:inn_proposed_list|122 (2019) imgt:mAb_366|imgt:inn_recommended_list|66 (2011) imgt:mAb_198|imgt:inn_name|moxetumomab pasudotox imgt:MUC16|imgt:isTargetOf|imgt:IgG4-kappa_1173 imgt:mAb_251|imgt:hasProduct|imgt:Product_dc5d0295-91f0-3aeb-9b3e-15ed4c4c9f19 imgt:hasChainTypeLevel|skos:definition|allows to set the Level of granularity of a concept of ChainType. pubmed:7682986|dc:contributor|Briggs S imgt:IgG1-nd_41|imgt:hasConstruct|imgt:Construct_41 imgt:StudyProduct_fb834bc6-a761-32b7-ac2b-49f6c3d77751|imgt:hasDecision|_:B1bf75098e709ec0814604a314a240213 imgt:hasConfigurationType|rdf:type|owl:ObjectProperty imgt:StudyProduct_41b94ce1-b65d-37bc-aa0f-a71002c3a9ae|imgt:hasDecision|_:B150ff4626a9f7b6cd3ed3da9a301a4ea imgt:Product_ca415bf9-d43d-31ef-b23e-bec5b4023720|imgt:commun_name|AMG-403 _:B6b1ed379b5ceb2c228d566b313a1cd98|imgt:hasStatut|imgt:approval imgt:mAb_1108|imgt:inn_proposed_list|124 (2020) imgt:StudyProduct_849db2fa-5569-30bf-9299-feb6f251a154|imgt:isStudyProductOf|imgt:Product_916014f3-4780-3901-8e7b-eba7e0eeb0d5 imgt:StudyProduct_e00e2ac8-e24b-3067-9bd3-e8f55c8a2ddd|rdfs:label|StudyProduct_e00e2ac8-e24b-3067-9bd3-e8f55c8a2ddd imgt:Clone_94|obo:RO_0002162|imgt:Homsap imgt:IgG1-kappa_330|obo:RO_0002162|imgt:Hum imgt:StudyProduct_95dd2585-8bee-30e2-8c5c-e42a828f78ce|imgt:application_type|Therapeutic imgt:Product_1e6dcbf5-881e-3dae-a9c2-c7d5ca5aaceb|imgt:commun_name|SDZ MSL 109 imgt:Construct_291|rdf:type|imgt:Construct imgt:Segment_1041_1|rdfs:label|Segment_1041_1 imgt:Alexion_Pharmaceuticals_Inc|imgt:produces|imgt:Product_9ccb1dfa-df47-33b6-91db-84c6d523a3dd imgt:Product_a8c88a00-55f6-36e4-a163-a5e3d16adab7|rdfs:label|Product_a8c88a00-55f6-36e4-a163-a5e3d16adab7 imgt:FSH_(follicle-stimulating_hormone)|rdf:type|imgt:SegmentLabels imgt:Construct_205|obo:BFO_0000051|imgt:Segment_205_1 imgt:StudyProduct_a3eeba9e-d742-3b4f-951f-bc3d277da478|imgt:application_type|Therapeutic imgt:Oncternal_Therapeutics|rdf:type|obo:NCIT_C54131 imgt:Solid_tumors|imgt:isClinicalIndicationOf|imgt:StudyProduct_54944a58-885e-3faa-910e-36c9c4a047ee imgt:Segment_909_1|obo:BFO_0000050|imgt:Construct_909 imgt:TF2|rdfs:label|TF2 obo:SO_0000572|rdf:type|owl:Class pubmed:7991583|rdfs:label|PMID_7991583 imgt:Construct_4|imgt:isConstructOf|imgt:IgG1-nd_4 _:Bddbdda5cd5c69c082b0a16a4e5f81d8c|dc:date|2010-02-18 imgt:VH-VH-VH|imgt:construction_detail|VH - VH - VH imgt:StudyProduct_296f279e-8084-328b-b38c-9b44cf4d7e5b|imgt:application_type|Therapeutic imgt:1UCB|imgt:isImgtStructureEntryOf|imgt:mAb_150 imgt:StudyProduct_ec9edeaa-3a0d-3d75-9378-824aa1457d40|imgt:development_technology| YB2/0 cell line: low fucosylation imgt:8932|imgt:isImgtStructureEntryOf|imgt:mAb_21 imgt:StudyProduct_cad06487-fba8-32fe-ac47-aae7c63a6693|imgt:application_type|Therapeutic imgt:StudyProduct_4b851f49-d7ec-3723-ad3b-48dd091181b6|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_MTX_(methotrexate_resistant)_cells imgt:IgG1-kappa_MM_947|http://semanticscience.org/resource/SIO_000291|imgt:Felcat_IL31 imgt:IgG1-kappa_333|imgt:hasMolecularComponent|imgt:IG imgt:mAb_1174|rdfs:label|mAb_1174 imgt:Construct_1233|imgt:isConstructOf|imgt:scFv-kappa-heavy-CD28_(CO-TM-CY)-CD247_1233 imgt:Lymphocytopenia|imgt:isClinicalIndicationOf|imgt:StudyProduct_2a681d4d-fe7a-32d4-8416-27631a75f6a7 imgt:StudyProduct_156f8352-f12f-38a5-a6ac-4ec4ba7a2208|imgt:hasClinicalIndication|imgt:Non-alcoholic_fatty_liver_disease_(NAFLD) obo:RO_0002131|rdfs:range|faldo:Region imgt:11793|imgt:isImgtStructureEntryOf|imgt:mAb_1224 imgt:Johnson_&_Johnson|imgt:produces|imgt:Product_91cb264b-0c51-33f5-8f57-97e282af35f0 imgt:Segment_1085_1|rdf:type|imgt:Segment imgt:Construct_989|rdf:type|imgt:Construct imgt:StudyProduct_ee00fd15-4396-3146-9aa4-d1dc63eeb3c2|imgt:application_type|Therapeutic imgt:Construct_172|imgt:hasImgtLabel|imgt:IgG1-kappa _:B0798134bf6f92e4647cb27459895158b|imgt:hasDesignation|imgt:Orphan_drug imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_f5b5f2b6-8fd7-38b9-938b-4f838a392b75 imgt:StudyProduct_5511d3d8-82d2-35ce-8b66-66e212033b67|imgt:hasClinicalIndication|imgt:Systemic_lupus_erythematosus_(SLE) imgt:Leucocyte_immunoglobulin-like_receptor|rdf:type|owl:Class obo:NCIT_C106119|rdfs:subClassOf|obo:NCIT_C1909 imgt:StudyProduct_87b3c163-f46d-311c-9d15-c42b9f2bf7b1|rdf:type|obo:NCIT_C174271 imgt:Breakthrough_therapy|rdf:type|obo:NCIT_C25688 imgt:Product_cbd0baaf-87ab-3efd-87a0-619e0f9667a5|imgt:commun_name|rFVIIa-FP imgt:StudyProduct_fcef52ae-a97c-304d-b574-ed050298bbd7|imgt:isStudyProductOf|imgt:Product_a97d10f5-7176-34fb-8235-5903305f1d2d imgt:Product_be4ceb56-c2c1-3a7b-90f6-a24ff96b8e20|imgt:isProductOf|imgt:mAb_34 imgt:Genentech_Inc|imgt:produces|imgt:Product_480f91be-f048-34a5-9224-9a68a0291dd8 imgt:Lymphoma_diffuse_large_B_cell_(DLBCL)|imgt:isClinicalIndicationOf|imgt:StudyProduct_325e5cda-6137-3a4e-80fe-43c7609968e4 imgt:mAb_64|imgt:inn_number|9343 imgt:LOCALIZATION|skos:definition|The LOCALIZATION axiom of the Formal IMGT-ONTOLOGY or IMGT-Kaleidoscope postulates that molecules, cells, organs, organisms or populations and their processes and relations have to be localized in time or space. At the molecular level in the field of immunogenetics, the concepts of localization allow to characterize the localization of IG and TR genes. pubmed:1718599|dc:contributor|Nadler LM _:B13705560a78d885ea5d04e487d56be57|imgt:isDecisionOf|imgt:StudyProduct_ce85069f-44c6-3077-953e-6d7a0efeb14f imgt:FPIA_%5BPROTEIN_2REPEATS%5D2-FC_213|imgt:hasMolecularComponent|imgt:FPIA imgt:PROTEIN_1DOMAIN_997|imgt:isMabReceptorOf|imgt:mAb_997 imgt:Clone_214|rdf:type|obo:NCIT_C37925 _:Bad71ddd55f2e8b44efe435b165dbfde1|imgt:isDecidedBy|imgt:EMA imgt:StudyProduct_2dd3404f-1979-37e2-9af4-6960a4e508ea|imgt:application_type|Therapeutic imgt:IgG1-kappa_758|rdfs:label|IgG1-kappa_758 imgt:Lymphoma_follicular_(FL)|imgt:isClinicalIndicationOf|imgt:StudyProduct_cb7ae197-a0ed-3f1f-933f-f7be3e2b0d51 imgt:IG-Light-Kappa-IGKC|imgt:defines|imgt:Fab-Gamma-2-b_Kappa imgt:StudyProduct_e7d55985-d5f8-3eb2-98ae-964a79e5b78a|imgt:hasExpressionSystem|imgt:_Pichia_pastoris_(Komagataella_pastoris) imgt:mAb_1155|imgt:hasProduct|imgt:Product_e1a45191-3ce1-3854-8d8e-bbc72e11be98 _:B99beaa92ec1285a5f38148d252b33c7a|imgt:hasStatut|imgt:approval imgt:StudyProduct_bcd14e53-bdb2-3301-8a94-47c1c744e4a4|imgt:application_type|Therapeutic imgt:IgG1-kappa_330|rdfs:label|IgG1-kappa_330 imgt:Product_d83f11d1-0413-38d7-9027-724429ec0e9f|imgt:hasStudyProduct|imgt:StudyProduct_082e3d53-1b6b-37ea-a6c2-900c6e405048 imgt:Peripheral_T/NK_cell_lymphoma|imgt:isClinicalIndicationOf|imgt:StudyProduct_422b563f-43e3-308c-8b21-895b0539ecd5 imgt:StudyProduct_cf211e0b-6a75-3b78-919e-27956a3554aa|imgt:application_type|Therapeutic imgt:StudyProduct_cff2ed84-8d7a-3c61-9a87-baf0ef1d3d9c|imgt:isStudyProductOf|imgt:Product_f5534f35-f0b5-3400-a66f-297adc7553e0 imgt:IgG1-kappa_1178|imgt:hasConstruct|imgt:Construct_1178 imgt:Segment_188_1|imgt:has_rank|1 imgt:Segment_843_2|imgt:hasImgtLabel|imgt:IGHG2 imgt:mAb_165|imgt:hasBiosimilar|imgt:cyltezo™ imgt:StudyProduct_bbc7d3de-0c87-36ae-bd44-6a67cbd3c900|imgt:hasClinicalPhase|imgt:Phase_III imgt:G1-kappa_scFv-h-CH2-CH3_1075|rdf:type|imgt:MAbReceptor imgt:StudyProduct_7f83ca8a-97b1-303e-9748-a108364e17c5|imgt:hasClinicalPhase|imgt:Phase_M imgt:IFNA2_(interferon_alpha_2)_*b_(R46_H57)_ 24-188|imgt:construction_detail|IFNA2 (interferon alpha 2) *b (R46,H57)  24-188 imgt:IgG1-kappa-8cys-drug_722|imgt:isMabReceptorOf|imgt:mAb_722 imgt:IgG1-nd_271|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-nd.png imgt:Cancers_colorectal_(CRC)_metastatic|imgt:isClinicalIndicationOf|imgt:StudyProduct_b5d3394f-e7b8-36c2-ade9-39e65a0dd3db imgt:Product_c299e202-690b-3ffc-8c53-e45056548ad0|imgt:hasStudyProduct|imgt:StudyProduct_53183842-71ef-3bbc-a045-3c4e63aa385f imgt:Product_b9226bfe-9ade-3567-89de-3debdadbfd1e|imgt:isProducedBy|imgt:ImClone_Systems_Inc imgt:CARRIER_BIG-PROTEIN_1DOMAIN_691|imgt:hasMolecularComponent|imgt:CPCA imgt:ELP-PEPTIDE_746|imgt:isMabReceptorOf|imgt:mAb_746 imgt:Product_7e18bb4f-f694-3944-a8d9-13b24a315559|imgt:hasStudyProduct|imgt:StudyProduct_5fd82fcb-b163-3742-9246-bea610f85fff imgt:mAb_886|imgt:clinical_trials|5 studies found, 4 recruiting imgt:mAb_754|rdfs:label|mAb_754 imgt:mAb_262|rdfs:label|mAb_262 imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_47fe8ede-ae52-3e23-a933-4892db166791 imgt:mAb_737|imgt:inn_name|sampeginterferon beta-1a imgt:IL21|imgt:isTargetOf|imgt:IgG1-kappa_941 imgt:mAb_911|imgt:inn_name|cendakimab imgt:TNFRSF17|imgt:isTargetOf|imgt:IgG4-kappa_1263 imgt:StudyProduct_af7ab420-55ff-3688-8469-664dcd2fd595|rdfs:label|StudyProduct_af7ab420-55ff-3688-8469-664dcd2fd595 _:B17df8f45f893d670be2fcb0ef0d4d3c7|imgt:isDecidedBy|imgt:FDA imgt:CD80|skos:definition|CD80 (B7-1, CD28LG1) imgt:IG-GAMMA-1_V-KAPPA-C-LAMBDA|rdfs:label|IG-GAMMA-1_V-KAPPA-C-LAMBDA imgt:IgG3-kappa_199|rdfs:comment|IgG3 - kappa imgt:StudyProduct_4aa7a948-2d16-30f7-83bb-a19c45424e20|rdf:type|obo:NCIT_C174271 imgt:ITGA2B_ITGB3|rdfs:label|ITGA2B_ITGB3 imgt:Construct_729|imgt:isConstructOf|imgt:IgG1-lambda_729 imgt:Segment_100_1|obo:BFO_0000050|imgt:Construct_100 imgt:VH-V-kappa-CH2-CH3_488|rdfs:comment|VH - V-kappa - CH2 - CH3 imgt:is_completed|rdfs:label|is_completed imgt:mAb_1248|rdfs:label|mAb_1248 imgt:StudyProduct_6fa2687b-6915-3b16-86ac-2b3309cc6cbc|rdfs:label|StudyProduct_6fa2687b-6915-3b16-86ac-2b3309cc6cbc pubmed:7985542|imgt:isBibliographicReferenceOf|imgt:mAb_26 imgt:Construct_821|imgt:isConstructOf|imgt:FPIA_%5BPROTEIN_4REPEATS%5D2-3S-FC_821 imgt:StudyProduct_773868e5-eff6-3aac-a866-62bdf844a898|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_7ae73e7a-7e50-321a-8cda-c099c16e56fc|rdf:type|obo:NCIT_C174271 imgt:Clone_160|obo:RO_0002162|imgt:Musmus imgt:StudyProduct_9499cb2a-4142-3f81-ae02-a71d5a9ec790|imgt:hasClinicalIndication|imgt:Psoriatic_arthritis_(PSA) _:B8f235f29f329d465c66a219e27c4d1ce|imgt:isDecisionOf|imgt:StudyProduct_c2f36ef8-ad43-3248-a9b9-9f002f265773 imgt:StudyProduct_b0bb0702-9e9a-3783-97b1-b32ed1cc0a37|imgt:hasClinicalPhase|imgt:Phase_III imgt:Product_964f3a74-fab3-3a7d-b372-0346f67780f4|imgt:isProducedBy|imgt:Nobelpharma_Co_Ltd obo:NCIT_C167050|rdfs:subClassOf|obo:NCIT_C1909 imgt:StudyProduct_e2f142a9-d738-374b-9de3-f9212eca3c7b|imgt:hasClinicalPhase|imgt:Phase_II imgt:Segment_224_1|obo:BFO_0000050|imgt:Construct_224 imgt:Product_5599efd0-7eee-32e0-ad93-253e80b8b7e3|imgt:commun_name|785A070802 _:Bce25bc9a87435ede4610d7dab9305954|rdf:type|obo:NCIT_C53285 imgt:StudyProduct_63df4182-a56c-3791-98cd-3d2446f520ce|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_ba051135-cbbf-3584-9f69-8c5f8a7bcd62|imgt:development_technology| Medarex’s UltiMAb® imgt:Hepatocellular_carcinoma_(HCC)|imgt:isClinicalIndicationOf|imgt:StudyProduct_5a94926c-6eaf-334c-bbd7-458628b36de7 imgt:StudyProduct_49b9216b-c4b3-320b-a46c-debe10ac306f|rdfs:label|StudyProduct_49b9216b-c4b3-320b-a46c-debe10ac306f imgt:Bristol-Myers_Squibb|imgt:produces|imgt:Product_276f54fa-be22-3c7b-a5d4-425797582646 _:B5ecdb45c3fc7b6bd6906aa8012f0342b|imgt:isDecisionOf|imgt:StudyProduct_3132b9f6-aaad-3395-9967-548169c7bd46 obo:NCIT_C152782|rdfs:subClassOf|obo:NCIT_C1909 imgt:GHR_(Pr19-150)|rdfs:label|GHR (Pr19-150) imgt:SELPLG|imgt:isTargetOf|imgt:MAbReceptor_833 pubmed:23307031|dc:contributor|Matlawska-Wasowska K imgt:IgG1-nd_25|imgt:isMabReceptorOf|imgt:mAb_25 imgt:Product_97551870-12ac-39cb-a566-96ca9d85ebc5|rdfs:label|Product_97551870-12ac-39cb-a566-96ca9d85ebc5 imgt:StudyProduct_4b572631-1446-330b-9486-e221894b7c40|imgt:isStudyProductOf|imgt:Product_0348fc3a-dd69-3bf2-bb93-d6d2b096d5f2 imgt:mAb_899|rdf:type|obo:NCIT_C169769 imgt:NOTCH3|obo:RO_0002162|imgt:Homsap imgt:mAb_492|imgt:hasOriginClone|imgt:Clone_492 imgt:mAb_730|rdf:type|imgt:INN imgt:Construct_385|rdf:type|imgt:Construct imgt:Product_7e5d1d6d-b55c-3e83-81ba-8f67e321c93b|imgt:isProducedBy|imgt:CytomX_Therapeutics_Inc imgt:Product_7cca64de-f3bb-30c5-bf9b-350701744112|imgt:hasStudyProduct|imgt:StudyProduct_1c9131bf-ec68-35f4-a459-fb100c20ff72 imgt:StudyProduct_bfa3a1bc-fc7c-368a-bff0-d8cb611a8fbf|rdfs:label|StudyProduct_bfa3a1bc-fc7c-368a-bff0-d8cb611a8fbf imgt:F(AB%27)2-DELTA_LAMBDA|skos:definition|F(ab')2 comprising the VH-CH1 domains from two H-DELTA chains and two L-LAMBDA chains imgt:Construct_1284|rdfs:label|Construct_1284 imgt:IgG4-kappa_472|http://semanticscience.org/resource/SIO_000291|imgt:PDCD1 imgt:mAb_588|imgt:inn_name|xentuzumab imgt:FN1-10|rdfs:label|FN1-10 imgt:Product_16598ce5-139e-369a-9c15-ff7fed2d1f12|imgt:isProducedBy|imgt:Roche_F_Hoffmann-La_Roche_Ltd imgt:Construct_1064|rdfs:label|Construct_1064 imgt:mAb_1208|imgt:hasMabReceptor|imgt:IgG1-kappa-4cys-drug2_1208 imgt:Product_b9a7e713-902d-3fb3-afff-5da968f3c336|imgt:isProducedBy|imgt:MacroGenics_Inc imgt:Asthma|imgt:isClinicalIndicationOf|imgt:StudyProduct_6d61fdae-1304-33c2-8720-c865ada225cd imgt:12159|imgt:isImgtStructureEntryOf|imgt:mAb_1279 imgt:IgG1-kappa_1090|imgt:isMabReceptorOf|imgt:mAb_1090 imgt:StudyProduct_d24549d2-16af-3305-88f2-6445585bd19e|imgt:development_technology| Medarex’s UltiMAb® imgt:9295|rdf:type|obo:NCIT_C25402 imgt:CD248|skos:definition|CD248 (endosialin, tumor endothelial marker 1, TEM1) obo:NCIT_C96757|rdf:type|owl:Class obo:NCIT_C166988|rdf:type|owl:Class imgt:Fab%27-G1-kappa-PEG-PEG_242|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/Fab'-G1-kappa-PEG-PEG.png imgt:Fab-Alpha_Lambda|imgt:isDescribedBy|imgt:FAB-ALPHA_LAMBDA imgt:Product_c5ef56a8-976b-3908-a950-7c23335315c5|imgt:isProducedBy|imgt:Mapp_Biopharmaceutical_Inc imgt:StudyProduct_f0431bbe-f9ca-3eba-a26f-88d04c64aaaf|imgt:isStudyProductOf|imgt:Product_b38076b1-97d5-32d7-963f-54f73830057b imgt:Product_5eb41d03-904f-31e2-99cf-e8e07792e97b|imgt:hasStudyProduct|imgt:StudyProduct_11eb3f72-0f2b-3790-be11-0d26f34cde2c imgt:mAb_634|imgt:hasProduct|imgt:Product_5dde1122-ca49-3ad6-8e30-d28049e1461d imgt:StudyProduct_4a815db4-c662-3d9e-a584-51db01c7a9fa|imgt:isStudyProductOf|imgt:Product_ffe79d3a-7340-3c62-883c-916bc4a8044e imgt:IgG1-kappa_1217|obo:RO_0002162|imgt:Homsap imgt:Product_546d6daa-5d28-3e8b-9d12-ffa5d6ed0afa|imgt:hasStudyProduct|imgt:StudyProduct_c4649a4e-c99c-3539-9c34-17152c87eed9 _:Ba6b3e5fbac750cbfdee8be8db91010f3|rdf:type|obo:NCIT_C53285 imgt:mAb_1208|imgt:inn_recommended_list|87 (2022) imgt:mAb_585|imgt:inn_number|10037 imgt:Segment_1273_1|rdf:type|imgt:Segment imgt:StudyProduct_659bf455-776a-356c-a03d-c231f4a90bfb|imgt:hasDecision|_:Bfa4a363b5e3cce6fa638b25ea13cf64a imgt:Product_73c8f272-2743-3eb0-8838-5a74f2a6d142|imgt:isProducedBy|imgt:BerGenBio_AS pubmed:18088084|dc:contributor|Hassan R imgt:Fab-G1-lambda_1191|imgt:hasMolecularComponent|imgt:IG imgt:G1-kappa_scFv-h-CH2-CH3_735|imgt:hasConstruct|imgt:Construct_735 imgt:_Tobacco_plant_Nicotiana_benthamiana|imgt:isExpressionSystemOf|imgt:StudyProduct_591a07d2-306a-3665-93e9-5761f2d56e3a imgt:IgG1-kappa_913|imgt:hasConstruct|imgt:Construct_913 imgt:Product_61b4397b-5f33-35bd-9e48-2503ed74686a|imgt:commun_name|anti-Tac(Fv)-PE38 imgt:StudyProduct_50560455-18be-3aa0-a51c-8721a7c66c11|imgt:hasClinicalIndication|imgt:Cancers imgt:Product_07a0f8df-d456-3179-a3a2-ab802e7d3e13|imgt:commun_name|BG00002 imgt:Clone_243|imgt:isOriginCloneOf|imgt:mAb_243 _:B4f1c0d53d7a69f3cfdd64d7782eb25f0|imgt:hasStatut|imgt:approval imgt:StudyProduct_f546d8a8-dbdd-37c5-ad86-10969591ce76|imgt:hasClinicalPhase|imgt:Phase_M imgt:binocrit®|rdfs:label|BINOCRIT® imgt:IgG1-kappa_1005|rdfs:label|IgG1-kappa_1005 imgt:StudyProduct_19fc649f-7083-3cef-91d4-f00a7feb01af|imgt:isStudyProductOf|imgt:Product_75f84b83-eb14-3a03-a9e0-3efba822c52f imgt:mAb_2|imgt:hasMabReceptor|imgt:IgG1-nd_2 imgt:Product_ab1469c5-6914-33ba-a094-bef28a95f7f3|rdfs:label|Product_ab1469c5-6914-33ba-a094-bef28a95f7f3 imgt:Product_a1bd042a-5618-349f-b413-1f465cdadc23|imgt:hasStudyProduct|imgt:StudyProduct_c0747058-c28c-31fa-8364-f8475c60a950 imgt:StudyProduct_af9be6be-ea5b-33ab-9ae0-3a9e93b1c12e|imgt:hasClinicalPhase|imgt:Phase_I imgt:IgG1-kappa_244|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:Construct_1197|imgt:hasImgtLabel|imgt:IgG4-kappa imgt:mAb_1062|rdf:type|imgt:INN imgt:mAb_739|imgt:inn_recommended_list|78 (2017) imgt:Solid_tumors|imgt:isClinicalIndicationOf|imgt:StudyProduct_46c56f9c-5366-3170-bda9-a73054c07bce imgt:StudyProduct_fafaa338-3a65-3f96-9bf7-6290eda1212b|imgt:isStudyProductOf|imgt:Product_0eb736c9-6065-3b28-af5d-d12963aca376 imgt:mAb_135|imgt:hasProduct|imgt:Product_cc81b200-a475-38e4-ac34-dc6fd03fa04b imgt:Construct_970|rdf:type|imgt:Construct imgt:StudyProduct_4814e59b-aeed-348f-9b94-2959517715f8|rdf:type|obo:NCIT_C174271 imgt:Product_7a1abd88-229a-3bf5-8243-84d6e7f846e5|imgt:hasStudyProduct|imgt:StudyProduct_094bbabf-87fa-3f74-8c08-4fb2775296d8 _:B64f0f03ba58b6f2d481ed6447010b07f|imgt:isDecisionOf|imgt:StudyProduct_32ca3e79-d321-3d7a-85a7-31eebcc38bf8 imgt:ENZ-XTEN_700|rdfs:comment|ENZ-XTEN imgt:mAb_1299|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=1299 imgt:Construct_165|rdfs:label|Construct_165 imgt:Segment_332_1|rdfs:label|Segment_332_1 _:Bca13937a998780d0222ae768225f837f|imgt:isDecisionOf|imgt:StudyProduct_f0115dbb-2f33-3902-9ee5-b841771466d8 imgt:Product_8a843cd1-05ec-3b12-8269-e99f43ea2baf|imgt:commun_name|AMG-330 imgt:StudyProduct_96a85267-79e5-38bd-a186-3eff727e5d32|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:11625|rdfs:label|11625 _:Bd489bfa320c4853ad10e975f7f475b64|rdf:type|obo:NCIT_C53285 imgt:StudyProduct_6b2977b7-c6a1-33d0-89f9-9dfc928a3a40|imgt:hasClinicalPhase|imgt:Phase_I imgt:StudyProduct_70b9a532-ec91-3494-b50f-e40c7adaae58|rdfs:label|StudyProduct_70b9a532-ec91-3494-b50f-e40c7adaae58 imgt:Segment_1156_2|rdfs:label|Segment_1156_2 imgt:J-C-gene|skos:definition|Identifies, for gDNA, molecule entities that are processed (usually orphon) with a germline J gene joined to a C gene in undefined configuration. J-C-gene is in germline configuration. obo:NCIT_C179129|rdfs:subClassOf|obo:NCIT_C1909 imgt:Product_6bc1d7d7-3572-3445-908f-a32d9aa7218d|imgt:commun_name|hRS7-SN-38 _:B387ac121563f930c1c364117366da962|dc:date|1992-12-01 imgt:StudyProduct_901a93fd-4460-3779-a192-04d20bf627bb|imgt:hasClinicalIndication|imgt:Cancers_non-small_cell_lung_(NSCLC) imgt:GCG_(glucagon)_146-178_(glucagon-like_peptide_2_GLP2)_2-glycine-peptide_2_analogue|rdfs:label|GCG (glucagon) 146-178 (glucagon-like peptide 2, GLP2) 2-glycine-peptide 2 analogue imgt:Segment_123_1|obo:BFO_0000050|imgt:Construct_123 imgt:Product_7059201d-e2a8-3adc-9d1e-93b8e0e1285d|rdfs:label|Product_7059201d-e2a8-3adc-9d1e-93b8e0e1285d imgt:Amgen|imgt:produces|imgt:Product_dafd22c1-b296-344b-a18a-fcd81228093f _:Ba5a12cb103757e091531982f7bfa1442|imgt:isDecidedBy|imgt:FDA imgt:Construct_729|rdf:type|imgt:Construct imgt:mAb_800|imgt:inn_proposed_list|118 (2017) imgt:StudyProduct_422b563f-43e3-308c-8b21-895b0539ecd5|rdfs:label|StudyProduct_422b563f-43e3-308c-8b21-895b0539ecd5 imgt:Product_261d61fb-02a3-3c36-8a44-8027b7a60a03|imgt:isProducedBy|imgt:Amgen imgt:Segment_808_1|rdfs:label|Segment_808_1 imgt:germline|rdfs:label|germline imgt:StudyProduct_1a95c6e9-fbfd-3aa5-8b53-495de00d8b5d|imgt:application_type|Therapeutic imgt:StudyProduct_ca2e917d-4310-3324-a891-cf35fce0d42a|imgt:application_type|Therapeutic imgt:StudyProduct_55222386-95f1-3c39-b73c-b6e578c31ef5|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:LRR26|rdfs:label|LRR26 imgt:TNFSF13|skos:definition|TNFSF13 (tumor necrosis factor (TNF) superfamily member 13, APRIL, CD256) imgt:Autoimmune_diseases|imgt:isClinicalIndicationOf|imgt:StudyProduct_b470137b-16f7-3b18-a3f9-c8d64a66653c imgt:StudyProduct_1db01a4a-0599-3f66-acfb-95f6b0d781ee|imgt:isStudyProductOf|imgt:Product_804344aa-9846-368c-b3c2-764390d1bcc8 imgt:Construct_374|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:GPC3|obo:RO_0002162|imgt:Homsap imgt:mAb_730|imgt:inn_proposed_list|116 (2016) imgt:mAb_294|imgt:hasProduct|imgt:Product_c4281e8f-8be3-33d2-a3b5-de0eaf8f6d6d imgt:Calypso_Biotech_BV|rdfs:comment|Plan-les-Ouates , Switzerland imgt:IgG2a-nd_120|imgt:isMabReceptorOf|imgt:mAb_120 imgt:Product_bba8672b-beba-3b1b-a573-c401cafeeb59|imgt:commun_name|JNJ-8081 imgt:Segment_653_1|imgt:has_rank|1 imgt:mAb_1093|imgt:hasProduct|imgt:Product_6d00b4b8-121c-3156-854d-ae9f08aba45a imgt:StudyProduct_32ca3e79-d321-3d7a-85a7-31eebcc38bf8|imgt:hasClinicalIndication|imgt:Celiac_disease imgt:StudyProduct_8dbf6b8e-61d6-3faa-b68f-46ef365b37fb|imgt:isStudyProductOf|imgt:Product_d688aa3b-aa3d-3d8e-9f4f-2f22e5a667f9 imgt:mAb_43|imgt:hasProduct|imgt:Product_bba2d2e3-c1d5-3df4-a957-7bf830c1b58a imgt:10316|rdfs:label|10316 imgt:IgG4-kappa_606|rdfs:comment|IgG4 - kappa imgt:Pseudomonas_aeruginosa_nosocomial_pneumonia|rdf:type|obo:NCIT_C185637 imgt:Construct_650|rdfs:label|Construct_650 imgt:F(ab’)2-Gamma-4_Lambda|rdfs:label|F(ab’)2-Gamma-4_Lambda imgt:Product_7a640788-9a95-363a-8d3a-541b7fcd35e8|imgt:commun_name|huMAb-OX40L imgt:Segment_218_1|imgt:has_rank|1 imgt:StudyProduct_33bca2be-a910-3fcc-bb8d-f94fabf2cbc3|imgt:application_type|Therapeutic imgt:Age-related_macular_degeneration_(AMD)_neovascular_(wet)|imgt:isClinicalIndicationOf|imgt:StudyProduct_5fdbf507-352c-34e8-a0b0-00c7a6c7863e imgt:Product_251879e5-8c72-335f-89ef-7f76ad06fea2|rdf:type|obo:NCIT_C51980 imgt:StudyProduct_fb21276c-2e68-3a34-a1e0-0370a33b37c2|imgt:application_type|Therapeutic obo:NCIT_C139553|rdfs:subClassOf|obo:NCIT_C1909 imgt:ConservedAALabel|rdf:type|owl:Class imgt:Product_c5655770-b6fa-3ca9-a0be-de4d35304022|rdf:type|obo:NCIT_C51980 imgt:StudyProduct_a4a7bca6-26d4-3a2d-b63d-927b4e781968|rdfs:label|StudyProduct_a4a7bca6-26d4-3a2d-b63d-927b4e781968 imgt:Clone_181|rdfs:label|Clone_181 imgt:9636|rdf:type|obo:NCIT_C25402 imgt:mAb_859|rdf:type|imgt:INN imgt:mAb_1147|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=1147 imgt:Non-alcoholic_steatohepatitis_(NASH)|imgt:isClinicalIndicationOf|imgt:StudyProduct_84b54caa-ef19-3736-8e05-8b6617854431 imgt:Viventia_Biotechnologies_Inc|rdfs:label|Viventia Biotechnologies Inc. imgt:StudyProduct_330d1681-6a7e-3450-9bbd-4065f27813aa|rdf:type|obo:NCIT_C174271 imgt:mAb_430|rdfs:label|mAb_430 imgt:StudyProduct_8deb92d7-c9b3-3497-aa96-ca650a98e7d1|rdfs:label|StudyProduct_8deb92d7-c9b3-3497-aa96-ca650a98e7d1 imgt:StudyProduct_ace35e24-f1a9-3bbd-b8fa-6b97394812a3|rdf:type|obo:NCIT_C174271 imgt:Cancers_nasopharyngeal|rdfs:label|Cancers_nasopharyngeal imgt:mAb_1106|imgt:hasMabReceptor|imgt:IgG1-kappa_1106 imgt:StudyProduct_3f946c8d-a436-351a-8ff1-340d491a42a7|imgt:development_technology| POTELLIGENT® technology (afucosylation) imgt:Segment_866_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Product_7bade22b-a6c5-3b9d-9336-099f730a41de|rdf:type|obo:NCIT_C51980 imgt:Product_aeb9b1ac-6efd-336f-af32-ebc0ea62dbd3|imgt:isProducedBy|imgt:Roche_F_Hoffmann-La_Roche_Ltd imgt:Product_30984d74-c01e-3818-be62-a95c03ad4613|imgt:isProductOf|imgt:mAb_153 imgt:mAb_936|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=936 imgt:Sophiris_Bio_Inc|rdfs:label|Sophiris Bio, Inc. imgt:IgG1-kappa_1154|rdfs:label|IgG1-kappa_1154 imgt:Product_3957ad43-a072-3d12-9355-7674de66eb12|rdfs:label|Product_3957ad43-a072-3d12-9355-7674de66eb12 imgt:IgG1-kappa_966|rdfs:comment|IgG1 - kappa imgt:StudyProduct_4cd327d5-becb-33b0-9063-1b4d45383724|imgt:development_technology| Cambridge Antibody Technology (CAT) human antibody phage display library imgt:Product_c7cf4dec-df13-33c9-9a7e-798c0993539c|imgt:comercial_name|INTRON® A imgt:Product_0c4ce40c-4004-3873-ac20-3d6e604874e8|imgt:isProducedBy|imgt:Biogen_Inc imgt:Product_f4af35da-7830-3280-b962-8cc6e7f4bd35|imgt:isProducedBy|imgt:Seattle_genetics_Inc imgt:mAb_920|imgt:inn_recommended_list|82 (2019) imgt:PEPTIDE_711|imgt:hasConstruct|imgt:Construct_711 imgt:StudyProduct_c9240909-e6ce-3134-b3c0-f9bc48f5d4f4|rdfs:label|StudyProduct_c9240909-e6ce-3134-b3c0-f9bc48f5d4f4 https://doi.org/10.1371/journal.pmed.0030237|dc:contributor|Cheung C.Y. imgt:IgG1-kappa_887|imgt:isMabReceptorOf|imgt:mAb_887 imgt:Construct_1300|obo:BFO_0000051|imgt:Segment_1300_1 imgt:TNC-ALB|rdfs:label|TNC-ALB imgt:mAb_570|imgt:hasMabReceptor|imgt:IgG1-kappa_570 imgt:Construct_109|imgt:hasImgtLabel|imgt:IgG2a-nd imgt:OtherLabel|rdfs:label|OtherLabel imgt:StudyProduct_0fca7506-9287-3470-a77f-f57284843269|rdf:type|obo:NCIT_C174271 imgt:Clone_1216|rdfs:label|Clone_1216 imgt:StudyProduct_f91ef26e-4be5-3cf2-b150-bdc12f32826e|rdf:type|obo:NCIT_C174271 imgt:Product_65f1a583-9ab6-38d8-8b26-1a11dfa24b99|imgt:comercial_name|ZENAPAX® (EC withdrawal 2009) imgt:Segment_1064_1|rdfs:label|Segment_1064_1 imgt:StudyProduct_87e2c5f1-33e0-38ab-a626-e465e699fb62|imgt:isStudyProductOf|imgt:Product_5dea998c-cfea-32c4-a7bd-01fd1839b7c7 imgt:Product_293982f0-db82-3a23-94e8-ade06e297476|imgt:hasStudyProduct|imgt:StudyProduct_63bd63f0-1c52-3759-9c53-b9217732b250 imgt:Construct_413|rdf:type|imgt:Construct imgt:IgG1-kappa_958|imgt:isMabReceptorOf|imgt:mAb_958 imgt:Dementia_Alzheimer_s_type|imgt:isClinicalIndicationOf|imgt:StudyProduct_4e03a35f-639e-3c28-925a-2505a32230fa imgt:StudyProduct_185b82b9-df56-3ad2-94f8-31f51bdf8e85|rdfs:label|StudyProduct_185b82b9-df56-3ad2-94f8-31f51bdf8e85 imgt:Product_84e76124-e7a6-3d53-bb0d-67db69ff6aa5|imgt:isProducedBy|imgt:Genzyme_Corp imgt:FPIA_%5BFC-%5BPEPTIDE-PROTEIN%5D2%5D3_581|imgt:isMabReceptorOf|imgt:mAb_581 imgt:Segment_113_1|imgt:hasImgtLabel|imgt:Fab-G1-nd imgt:IgG1-kappa_MM_111|obo:RO_0002162|imgt:Musmus imgt:IL1RAP|rdf:type|obo:NCIT_C25702 imgt:mAb_1131|imgt:hasProduct|imgt:Product_380468a1-298c-37f8-8d02-622fb021aa02 imgt:StudyProduct_32077acd-765d-3532-9668-00e229d622c8|imgt:hasExpressionSystem|imgt:_CHO-K1 imgt:StudyProduct_ec3e69b2-60fd-38b8-824f-479713d10289|rdfs:label|StudyProduct_ec3e69b2-60fd-38b8-824f-479713d10289 obo:NCIT_C171817|rdf:type|owl:Class imgt:Segment_92_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:StudyProduct_02ea65e9-4c4d-37f8-997d-8e64aeddc41b|imgt:hasDecision|_:B596f0f40c96d876c926025362fd2a232 imgt:mAb_832|imgt:clinical_trials|10 studies found, 3 recruiting imgt:Clan|owl:disjointWith|imgt:Group _:Bfdf098c70fc2412800c67a61c047a3e6|imgt:hasDesignation|imgt:Orphan_drug imgt:mAb_1075|imgt:hasMabReceptor|imgt:G1-kappa_scFv-h-CH2-CH3_1075 imgt:mAb_682|imgt:imgt_note| epoetin alfa INN definition is the one amended in L66 (1991). Binds to the erythropoietin receptor on erythroid progenitor cells, stimulating RBC production and differentiation. imgt:_E.coli_(Escherichia_coli)|imgt:isExpressionSystemOf|imgt:StudyProduct_f4c6b23a-506f-3b37-be20-32b17c3bfc58 _:B8dd87d9130853998597eca0f5cfbc731|rdf:type|obo:NCIT_C53285 imgt:Segment_875_1|obo:BFO_0000050|imgt:Construct_875 imgt:mAb_399|rdf:type|obo:NCIT_C2811 imgt:Cancers|imgt:isClinicalIndicationOf|imgt:StudyProduct_b29f4dc1-8aa0-3662-989e-415c06c97bf5 imgt:StudyProduct_b44fe2d8-f4da-3c16-a5f7-2d62a5c7deb7|rdfs:label|StudyProduct_b44fe2d8-f4da-3c16-a5f7-2d62a5c7deb7 imgt:StudyProduct_6616f4bc-be90-3a89-a4ee-a36f12cb72d3|imgt:hasClinicalIndication|imgt:Feline_osteoarthritis_(OA) imgt:mAb_1197|imgt:inn_name|ligufalimab imgt:mAb_899|imgt:clinical_trials|4 studies found, 2 recruiting imgt:mAb_699|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=699 imgt:Product_08bd6972-3307-3ac1-9be9-270ca2564841|imgt:commun_name|SYN023 imgt:J-SPACER|skos:definition|12 or 23 nucleotide spacer between the J-NONAMER and the J-HEPTAMER of a J-RS _:B4ba5b43fd4f0db63e27e48e0b777c140|dc:date|2015-03-04 imgt:IgG1-kappa_652|rdfs:label|IgG1-kappa_652 imgt:Product_1409f0bb-81d5-3a94-aea6-99517bf76035|imgt:commun_name|rFIXFc-XTEN _:Be8a20742098bdb2bb357b213131a19ec|imgt:hasStatut|imgt:approval imgt:StudyProduct_3405bca4-94e9-300a-9364-2b8815237935|imgt:isStudyProductOf|imgt:Product_d162eac6-223f-3784-93c7-8637ba2b95cc imgt:IgG1-kappa_661|rdf:type|imgt:MAbReceptor imgt:mAb_788|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=788 pubmed:8769601|dc:contributor|Ilson B imgt:StudyProduct_cfc283b3-c688-3da8-ad58-33f8486263eb|imgt:hasDecision|_:B184659daf20e103d54f208ab569686a7 imgt:mAb_648|rdf:type|obo:NCIT_C171835 imgt:Construct_245|imgt:isConstructOf|imgt:FPIA_%5BPROTEIN_4REPEATS%5D2-FC_245 imgt:mAb_1240|imgt:inn_name|briquilimab imgt:StudyProduct_9a45a23e-ef31-3fb2-ab29-3865864ef13a|imgt:application_type|Therapeutic imgt:Product_0dea9063-7da8-3df3-9249-b5cddeecec56|imgt:isProducedBy|imgt:Glycotope_GmbH imgt:Cancers_head_and_neck|imgt:isClinicalIndicationOf|imgt:StudyProduct_151b8421-560f-3a04-9445-3ac5bd3c9d3a imgt:TR-BETA-2-VH-V-KAPPA|rdfs:label|TR-BETA-2-VH-V-KAPPA imgt:StudyProduct_b0858c8e-e130-3de5-8485-057e1651450c|imgt:hasClinicalPhase|imgt:Withdrawn imgt:mAb_978|rdfs:label|mAb_978 imgt:Product_ed1e8186-4f31-37d5-85c3-9b5b8b1a524f|imgt:hasStudyProduct|imgt:StudyProduct_0baedbe6-1604-34c0-94ab-a794447ae333 imgt:Product_d61df4aa-b1c6-3a08-a7ca-b17b107e0a96|imgt:commun_name|TJ-004309 imgt:FAB-GAMMA-2-B_LAMBDA|imgt:describes|imgt:Fab-Gamma-2-b_Lambda pubmed:8844835|dc:contributor|Narula SK pubmed:21330330|dc:contributor|Ricci F imgt:ITGA5|obo:RO_0002162|imgt:Homsap imgt:StudyProduct_5bdaac6d-ba9c-3f18-bdc9-82c9ce089909|rdf:type|obo:NCIT_C174271 imgt:mAb_835|imgt:inn_proposed_list|119 (2018) imgt:IgG2a-nd|rdf:type|imgt:SegmentLabels imgt:mAb_1150|imgt:hasOriginClone|imgt:Clone_1150 _:B83511847d8d583997cf99df54a162d9e|rdf:type|obo:NCIT_C53285 imgt:StudyProduct_591a07d2-306a-3665-93e9-5761f2d56e3a|imgt:application_type|Therapeutic imgt:Construct_320|obo:BFO_0000051|imgt:Segment_320_1 imgt:Construct_494|obo:BFO_0000051|imgt:Segment_494_1 imgt:Acute_gout|imgt:clinical_domain|Immunology imgt:mAb_176|imgt:hasMabReceptor|imgt:IgG1-kappa_176 imgt:Taxonomy_ID|dc:identifier|imgt_000321 imgt:Construct_530|imgt:hasImgtLabel|imgt:%5BFAS_(Fas_cell_surface_death_receptor_TNFRSF6_tumor_necrosis_factor_receptor_(TNFR)_superfamily_member_6_FAS1_APO-1_CD95)%5D2-IGHG1_Fc_(Fragment_constant) imgt:Clone_133|imgt:clone_name|NR-LU-10 imgt:StudyProduct_31db3412-1de4-3cda-93a1-620c8c9c19bf|imgt:hasClinicalIndication|imgt:Atopic_dermatitis_(AD) imgt:11904|rdfs:label|11904 imgt:Segment_14_1|imgt:hasImgtLabel|imgt:F(ab)2-nd-nd imgt:Product_ee3787f8-7750-3f82-81f2-4aaf222c5ffd|imgt:isProducedBy|imgt:Bristol-Myers_Squibb imgt:Segment_399_1|rdfs:label|Segment_399_1 imgt:mAb_592|imgt:hasMabReceptor|imgt:IgG1-kappa_592 imgt:Clone_1061|rdf:type|obo:NCIT_C37925 imgt:mAb_943|imgt:hasOriginClone|imgt:Clone_943 imgt:Segment_1227_2|obo:BFO_0000050|imgt:Construct_1227 imgt:PROTEIN_1DOMAIN_917|http://semanticscience.org/resource/SIO_000291|imgt:LHCGR imgt:Amgen|imgt:produces|imgt:Product_3d3847b0-2ca8-3154-aa57-18221948bd0d imgt:Segment_462_1|rdf:type|imgt:Segment pubmed:7682986|dc:contributor|Eida SJ imgt:Construct_94|imgt:hasImgtLabel|imgt:IgG1-lambda imgt:mAb_799|imgt:inn_recommended_list|80 (2018) imgt:10843|imgt:isImgtStructureEntryOf|imgt:mAb_864 imgt:StudyProduct_fbb4cf37-a488-33e7-87cc-3e9d916c14dd|imgt:hasClinicalIndication|imgt:Growth_hormone_(GH)_deficiency_pediatric imgt:mAb_1186|imgt:hasProduct|imgt:Product_08bd6972-3307-3ac1-9be9-270ca2564841 imgt:StudyProduct_439373f8-c0ae-3451-8ad8-d505c32172d3|imgt:isStudyProductOf|imgt:Product_35874c60-bbc8-3078-95f7-d5da364ab3b8 imgt:StudyProduct_80610928-6623-3030-a3d3-2a45b78f27bb|rdf:type|obo:NCIT_C174271 imgt:IgG1-kappa_1195|rdfs:label|IgG1-kappa_1195 imgt:Product_1e3e70cb-9c74-352f-bc15-c39c41590fbc|imgt:hasStudyProduct|imgt:StudyProduct_1833d0a8-c298-3a28-a897-c4ea51020252 imgt:StudyProduct_08ede5e9-5468-3e28-ab2c-a7204ea416e6|imgt:hasDecision|_:Be0bdf5dade1d2f2e0f211d7255deded4 imgt:mAb_25|imgt:hasMabReceptor|imgt:IgG1-nd_25 imgt:StudyProduct_506a8738-be67-31c5-b7a4-40d5065a88ce|imgt:hasClinicalPhase|imgt:Phase_M imgt:StudyProduct_24f7a218-01dc-3469-b000-c47934d7f395|rdf:type|obo:NCIT_C174271 imgt:Product_38467291-7ffe-3c19-9668-d0dbeafcd182|imgt:isProducedBy|imgt:Amgen imgt:mAb_574|rdf:type|imgt:INN imgt:Product_f04cdfd4-6994-39a9-83ff-19d51122d4c0|rdf:type|obo:NCIT_C51980 _:B02ce6bcbe50f8087e67877a80b0c4ef8|imgt:isDecidedBy|imgt:FDA imgt:mAb_1099|rdf:type|imgt:INN imgt:IgG1-lambda_909|rdfs:label|IgG1-lambda_909 imgt:Construct_354|rdf:type|imgt:Construct imgt:Segment_507_1|imgt:has_rank|1 imgt:IgG1-kappa_1094|imgt:hasConstruct|imgt:Construct_1094 imgt:StudyProduct_af1bf769-285d-3a3e-b8ab-7b4988d6ea1c|rdfs:label|StudyProduct_af1bf769-285d-3a3e-b8ab-7b4988d6ea1c imgt:mAb_1142|imgt:imgt_note| WHO Drug Information, Vol. 34, No. 3, 2020. Proposed INN List 124 – COVID-19 (special edition) (9 October 2020) pages 642-669. Proposed INN List 124 (19 December 2020, published on 22 January 2021) pages 929-1102. imgt:StudyProduct_1f9c25e9-dd47-3d6f-995e-3d7688808037|rdf:type|obo:NCIT_C174271 imgt:mAb_496|imgt:hasImgtStructureEntry|imgt:9932 pubmed:1873503|rdfs:label|PMID_1873503 imgt:StudyProduct_5a1d70be-9799-3766-a0cf-3fcdf0fffb95|imgt:application_type|Therapeutic imgt:Genzyme_Corp|imgt:produces|imgt:Product_c9b09440-3c97-37f9-a7a3-a051cfd3499c imgt:mAb_947|imgt:hasOriginClone|imgt:Clone_947 obo:NCIT_C120309|rdf:type|owl:Class imgt:Multiple_myeloma_(MM)|imgt:isClinicalIndicationOf|imgt:StudyProduct_95f8f51f-1152-388e-b759-713b64855faf imgt:scFv-kappa-heavy-CD8A(CO-TM)-CD28(CY1)-CD247(CY2)_1229|rdf:type|imgt:MAbReceptor imgt:StudyProduct_976548a2-8826-3492-9d76-e971038eae5b|imgt:hasClinicalIndication|imgt:GE_Junction_Cancer imgt:Construct_924|obo:BFO_0000051|imgt:Segment_924_1 imgt:Product_29ed30a2-7708-3212-b64a-672c17f2dab4|imgt:commun_name|90Y-epratuzumab tetraxetan imgt:Construct_1099|rdfs:label|Construct_1099 imgt:Construct_250|obo:BFO_0000051|imgt:Segment_250_1 _:Ba120394fe5a9a2ad93dabda9fcec9cf8|imgt:isDecidedBy|imgt:FDA obo:NCIT_C174831|rdf:type|owl:Class imgt:Segment_1222_1|rdf:type|imgt:Segment imgt:mAb_646|imgt:hasProduct|imgt:Product_87b4f91f-0f72-3325-99d8-da600f41c074 imgt:IgG1-kappa_603|imgt:isMabReceptorOf|imgt:mAb_603 imgt:StudyProduct_be5358f9-3086-3522-8547-d074b5a04c80|rdfs:label|StudyProduct_be5358f9-3086-3522-8547-d074b5a04c80 imgt:Product_261d61fb-02a3-3c36-8a44-8027b7a60a03|rdfs:label|Product_261d61fb-02a3-3c36-8a44-8027b7a60a03 imgt:mAb_630|rdfs:label|mAb_630 imgt:IgG1-kappa_1215|http://semanticscience.org/resource/SIO_000291|imgt:Severe_acute_respiratory_syndrome_coronavirus_2_(SARS-CoV-2) imgt:mAb_1084|imgt:hasMabReceptor|imgt:G1-kappa_scFv-HEAVY-KAPPA-h-CH2-CH3_1084 imgt:StudyProduct_14857b94-bdbd-375d-bdb5-a38f05a59a47|imgt:isStudyProductOf|imgt:Product_67e444bf-348a-3c05-b092-025f7e9ae4b8 imgt:Product_ea1f78d0-d14b-3203-92b8-85d96b7f6211|imgt:isProducedBy|imgt:Xencor_Inc imgt:IgG1-kappa_526|http://semanticscience.org/resource/SIO_000291|imgt:CD274 imgt:mAb_400|imgt:hasProduct|imgt:Product_e8622868-8b57-3e77-b971-d5d37d61b031 imgt:StudyProduct_76ed5004-fdcf-3c32-b93d-ddd111280196|imgt:application_type|Therapeutic imgt:ENZ_1DOMAIN_695|rdfs:comment|ENZ_1DOMAIN imgt:StudyProduct_b8543b44-c170-31d9-9985-bdcaa45b9a1d|imgt:application_type|Therapeutic imgt:Product_950458ce-5b79-3a87-87fd-0d76107f13a3|imgt:hasStudyProduct|imgt:StudyProduct_3938e3bf-5caa-3bde-a890-4e5001b4a0ae imgt:IgG1-lambda_882|rdfs:label|IgG1-lambda_882 imgt:Clone_1237|imgt:clone_name|3D10 imgt:StudyProduct_6159ba4f-4996-34de-843a-75de55eb9a82|imgt:isStudyProductOf|imgt:Product_4a302c39-2f94-36f4-92b1-fd214b3ec5d3 imgt:_CHOK1SV_(lacking_the_glutamine_synthetase_(GS)_gene)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_49173df6-3d5e-3e39-9b77-e529b896ab32 _:Bcf165fec7b47d9588389e1b30d72da7b|imgt:isDecidedBy|imgt:FDA imgt:Construct_816|rdf:type|imgt:Construct imgt:StudyProduct_45bb821b-369c-31a4-bd72-4bb41b86a986|imgt:application_type|Therapeutic imgt:Product_4975e7ab-7850-3795-8d34-6526bce56205|imgt:commun_name|CR3022 imgt:StudyProduct_e063cc0f-b119-3176-8cb4-d7ecb41d8c08|rdf:type|obo:NCIT_C174271 imgt:Product_bf674d94-88de-356e-8f92-90585d0c6453|imgt:isProductOf|imgt:mAb_47 imgt:F(AB%27)2-ALPHA-1_LAMBDA|rdfs:label|F(AB')2-ALPHA-1_LAMBDA _:B353b778d16c846d7459a99d4de2a33f1|imgt:isDecidedBy|imgt:FDA imgt:IgG1-kappa-4cys-drug5_1289|imgt:conjugated_with| seco-DUBA imgt:IgG1-kappa_567|http://semanticscience.org/resource/SIO_000291|imgt:IL23A imgt:3'D-RS|skos:definition|recombination signal including the 3'D-HEPTAMER, 3'D-SPACER, and 3'D-NONAMER of the D-REGION of a D-GENE-UNIT (germline gDNA) (in the 3'UTR) or of the D-REGION of partially-rearranged V-D-GENE (in the 3'UTR), also in D-SEQUENCE (germline cDNA) or L-V-D-SEQUENCE (partially-rearranged cDNA) imgt:StudyProduct_0b0aa2e9-07ab-322d-8a83-b83c20b96031|imgt:hasClinicalPhase|imgt:Phase_II imgt:StudyProduct_bc693e63-c908-3a8a-9039-6678a1526aa9|imgt:hasClinicalPhase|imgt:Phase_I imgt:_CHOK1SV_(expresses_glutamine_synthetase_(GS)_endogenously)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_e156aa64-974c-3c8b-b484-c306fbda3c82 imgt:Construct_183|obo:BFO_0000051|imgt:Segment_183_1 imgt:Clone_834|imgt:isOriginCloneOf|imgt:mAb_834 imgt:mAb_1224|imgt:inn_number|11793 imgt:Age-related_macular_degeneration_(AMD)_neovascular_(wet)|imgt:isClinicalIndicationOf|imgt:StudyProduct_eecf5ce4-fbe7-3768-b545-33e1eb7be4a0 imgt:Product_7a614fd0-6c32-3499-b168-0b9896beedeb|imgt:commun_name|HuDreg-55 imgt:IgG1-lambda-kappa(2)_1119|rdf:type|imgt:MAbReceptor imgt:mAb_1256|imgt:inn_number|11954 imgt:Construct_963|rdf:type|imgt:Construct imgt:StudyProduct_58f8aee9-c2f0-36d7-87a8-70b094eb6267|imgt:application_type|Therapeutic imgt:G1-K-L_with_domain_crossover2_952|imgt:hasMolecularComponent|imgt:IG imgt:Segment_603_1|obo:BFO_0000050|imgt:Construct_603 imgt:mAb_399|imgt:hasImgtStructureEntry|imgt:8527 imgt:StudyProduct_685eb30b-6447-3724-aa29-186322adbbab|imgt:development_technology| Abgenix's XenoMouse® imgt:Segment_389_1|rdf:type|imgt:Segment imgt:mAb_1101|imgt:inn_recommended_list|85 (2021) imgt:Product_27b2ce59-fbe0-3c24-abf6-bf39a8d6c18b|imgt:commun_name|BC1-IL12 imgt:Construct_147|imgt:isConstructOf|imgt:IgM-nd_147 imgt:Product_0dc35379-efa3-32cf-93ef-6c88dcbb0baf|imgt:isProducedBy|imgt:Allergene imgt:mAb_27|imgt:hasProduct|imgt:Product_30252648-22d2-3bbf-924d-91ade8b9ddd3 imgt:Product_7a1abd88-229a-3bf5-8243-84d6e7f846e5|rdf:type|obo:NCIT_C51980 imgt:Segment_467_1|rdfs:label|Segment_467_1 imgt:StudyProduct_7b9bd74a-b763-35c0-949a-2f2387ddcbfe|imgt:hasClinicalIndication|imgt:Non-Hodgkin's_lymphoma_(NHL) imgt:PROTEIN_1DOMAIN_893|imgt:hasMolecularComponent|imgt:RPI imgt:StudyProduct_dcf8ea96-fca7-3822-8560-6029e8a77add|imgt:hasClinicalPhase|imgt:Phase_I imgt:StudyProduct_eb2001b5-f2f3-3b57-a83e-5363729c6bf5|imgt:hasClinicalIndication|imgt:Neutralisation_activity_of_HSV-1 imgt:Clone_966|rdfs:label|Clone_966 imgt:StudyProduct_da7b0ba2-8773-30c0-9a09-cf9dd7a94e71|imgt:application_type|Therapeutic imgt:mAb_244|imgt:hasImgtStructureEntry|imgt:5BVJ imgt:Clone_57|obo:RO_0002162|imgt:Musmus imgt:StudyProduct_49f1d43e-264d-3e76-badc-3188f448e9a7|rdfs:label|StudyProduct_49f1d43e-264d-3e76-badc-3188f448e9a7 imgt:Construct_654|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:StudyProduct_f5388cb8-36d9-38bd-8a0d-06112db2d0b9|imgt:hasClinicalPhase|imgt:Phase_I imgt:Product_70afe02b-053c-3bb6-a9a0-a670b69fb01d|imgt:isProductOf|imgt:mAb_1200 _:B30adb4b74d6632876dfb7aa680ef48d6|rdf:type|obo:NCIT_C53285 imgt:IG-GAMMA-1-%5BIL2%5D1_KAPPA|rdfs:label|IG-GAMMA-1-[IL2]1_KAPPA imgt:StudyProduct_c7928638-d1b3-315b-95a2-3d1e1262649f|imgt:development_technology| MorphoSys's HuCAL® phage library imgt:mAb_398|imgt:inn_recommended_list|62 (2009) imgt:mAb_560|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=560 imgt:Product_dafd22c1-b296-344b-a18a-fcd81228093f|imgt:isProducedBy|imgt:Amgen imgt:Segment_396_1|imgt:segment_detail|25-609 imgt:StudyProduct_b4f563ea-ccf4-35fb-8a1e-7a37ea7c98f2|imgt:hasClinicalPhase|imgt:Phase_I imgt:grastofil|rdfs:label|GRASTOFIL imgt:Diabetic_macular_edema|imgt:isClinicalIndicationOf|imgt:StudyProduct_39779c1c-7eeb-31f3-a2b4-36db904168b4 imgt:Segment_592_1|rdf:type|imgt:Segment imgt:Osteoarthritis_(OA)|imgt:isClinicalIndicationOf|imgt:StudyProduct_214336cc-76a7-3542-a798-589f69786a27 imgt:10825|rdfs:label|10825 _:B136d68e1d2a9127f59953e2e5d014e1d|dc:date|2021-02-09 imgt:IgD_Kappa|imgt:isDefinedBy|imgt:IG-Heavy-Delta-IGHD imgt:Segment_440_1|rdfs:label|Segment_440_1 imgt:Construct_774|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:StudyProduct_bd1cadae-bb8d-34d3-b194-3aa2a8a95dab|imgt:hasClinicalIndication|imgt:Pemphigus_vulgaris_(PV) imgt:StudyProduct_3d3b1b00-4296-3c01-9e34-6a5b725dbe90|imgt:hasClinicalIndication|imgt:Crohn's_disease_(CD) imgt:mAb_1299|imgt:inn_number|12107 imgt:StudyProduct_99e9dc7c-7bd4-3b09-9fe5-56caee4039e2|imgt:hasClinicalIndication|imgt:Migraine pubmed:20035694|dc:date|2009 imgt:Product_da697f5a-1938-3687-a103-54610aa291dd|imgt:isProductOf|imgt:mAb_596 imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_3c2f802d-354a-3caa-9d1a-424f1a8ee48d imgt:Beta2-Microglobulin|imgt:isDescribedBy|imgt:B2M imgt:IgG1-kappa-4cys-drug_571|obo:RO_0002162|imgt:Homsap imgt:mAb_799|imgt:clinical_trials|12 studies found, 6 recruiting _:Bae0be993847c5363b95c6cf4316e7ca1|imgt:isDecisionOf|imgt:StudyProduct_49630eff-3c50-36c8-b562-6cd7a15dde73 obo:NCIT_C78853|rdfs:subClassOf|obo:NCIT_C1909 imgt:_E.coli_(Escherichia_coli)|imgt:isExpressionSystemOf|imgt:StudyProduct_4d1292cd-3039-3fa6-b39f-3bfb654a58a7 imgt:StudyProduct_bc4be0a0-39f5-37b0-a4b0-a549dae1ceda|imgt:isStudyProductOf|imgt:Product_35c6ca74-2743-3354-8965-d8ba06e48503 imgt:StudyProduct_c6ba0088-98b9-3023-a557-82f9c72013ab|imgt:hasClinicalIndication|imgt:Cancers_gastric _:B2e2418692ab81ff29ba814860f51fe93|imgt:hasDesignation|imgt:Orphan_drug imgt:StudyProduct_5dfe30be-eda1-3639-8dea-4939175ff170|rdfs:label|StudyProduct_5dfe30be-eda1-3639-8dea-4939175ff170 imgt:StudyProduct_db8d8267-f336-3715-b038-38454987d7a7|imgt:hasExpressionSystem|imgt:_Sp2/0_mouse_hybridoma_cells imgt:Clone_1187|rdfs:label|Clone_1187 imgt:StudyProduct_d2145a16-62dc-3c18-906f-9edcf621d667|rdf:type|obo:NCIT_C174271 imgt:IgG4-kappa_609|imgt:hasMolecularComponent|imgt:IG imgt:toxin|rdfs:label|toxin imgt:IgG1-kappa_979|rdfs:label|IgG1-kappa_979 imgt:StudyProduct_cd05fc1e-523d-37e9-acc4-bf06c8ea5473|imgt:application_type|Therapeutic imgt:F(ab’)2-Alpha-2_Lambda|rdfs:label|F(ab’)2-Alpha-2_Lambda imgt:CARRIER_BIG-PROTEIN_1DOMAIN_685|http://semanticscience.org/resource/SIO_000291|imgt:GHR imgt:IgG1-kappa_238|imgt:isMabReceptorOf|imgt:mAb_238 imgt:Segment_933_1|imgt:hasImgtLabel|imgt:IL15RA imgt:mAb_725|imgt:inn_name|gilvetmab imgt:mAb_232|rdf:type|obo:NCIT_C62179 imgt:Construct_491|rdf:type|imgt:Construct imgt:Construct_825|rdf:type|imgt:Construct imgt:Fc-Gamma-4|rdfs:label|Fc-Gamma-4 imgt:CureTech|imgt:produces|imgt:Product_499c41a6-6810-367e-b82d-0cab484bef45 imgt:StudyProduct_a9bbcdc9-dd80-3727-9554-cafb62b18319|imgt:application_type|Therapeutic imgt:StudyProduct_52308407-6e88-3b91-8ebe-dc1fc6809c57|imgt:hasClinicalPhase|imgt:Phase_II imgt:Psoriatic_arthritis_(PSA)|imgt:isClinicalIndicationOf|imgt:StudyProduct_61d8846d-a4ae-3443-98e5-3e742149cd7e imgt:mAb_3|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=3 imgt:mAb_81|rdfs:label|mAb_81 imgt:StudyProduct_8562d300-1909-3706-8746-e3555642759e|imgt:application_type|Therapeutic imgt:Organ_transplant_immunological_rejection_suppression|imgt:isClinicalIndicationOf|imgt:StudyProduct_4ce0d1e9-2be8-3981-94d6-170ce87e91d5 imgt:StudyProduct_c6494b0e-d421-3873-97b8-dfb8dcff49a7|imgt:development_technology| MorphoSys's HuCAL® phage library imgt:F(ab%27)2-G1-kappa-PROT_906|obo:RO_0002162|imgt:Hum _:B64e681c19649b7dc1faf4a9fd2dcd0c6|rdf:type|obo:NCIT_C53285 imgt:StudyProduct_43cc644c-72e4-3a37-9bc5-aaadba950e4d|imgt:application_type|Therapeutic imgt:8380|imgt:isImgtStructureEntryOf|imgt:mAb_80 imgt:StudyProduct_198071b8-33f2-34af-af3c-077bd6f0ca62|imgt:application_type|Therapeutic imgt:mAb_234|imgt:hasMabReceptor|imgt:IgG1-kappa_234 imgt:mAb_175|imgt:centerwatch_link|http://www.centerwatch.com/drug-information/fda-approvals/drug-details.aspx?DrugID=1271 imgt:StudyProduct_daf44e44-c01d-3a29-b352-4b015d4fc247|imgt:hasClinicalIndication|imgt:Hematologic-blood_cancer imgt:mAb_796|imgt:inn_number|10652 imgt:IgG1-kappa-4lys-drug_1065|rdfs:comment|IgG1 - kappa - 4lys - drug imgt:MAbReceptor_208|imgt:hasMolecularComponent|imgt:IG obo:NCIT_C121775|rdfs:subClassOf|obo:NCIT_C1909 imgt:StudyProduct_1b5cf8e3-aa2f-38ba-b7e3-e35fff725897|imgt:hasClinicalPhase|imgt:Phase_M imgt:Product_39ce302d-6b9c-33f3-9a9e-b7291f2904f6|imgt:isProducedBy|imgt:Bristol-Myers_Squibb imgt:StudyProduct_34a5fae0-1542-3908-9606-16dd2eb055ac|imgt:hasClinicalPhase|imgt:Phase_I/II imgt:Product_770ad40f-89bb-3a05-96a9-fffbdef50c28|imgt:hasStudyProduct|imgt:StudyProduct_3f74c4e2-4cae-3809-815c-52a4ccb76660 imgt:StudyProduct_bbf45e5e-377b-3639-b622-b079804455bc|imgt:hasClinicalIndication|imgt:Melanoma imgt:Product_93b7132b-5be4-3248-9d55-bb48290a5de1|imgt:hasStudyProduct|imgt:StudyProduct_8deb92d7-c9b3-3497-aa96-ca650a98e7d1 imgt:mAb_753|rdfs:label|mAb_753 obo:RO_0001019|owl:inverseOf|obo:RO_0001018 imgt:Product_88568e72-96c0-305a-a89f-24f789162533|rdf:type|obo:NCIT_C51980 imgt:Influenza_B_infection|imgt:isClinicalIndicationOf|imgt:StudyProduct_a234ffce-a68d-3cca-ab1e-c3c3af138d1d imgt:mAb_818|imgt:hasMabReceptor|imgt:%5BPEPTIDE-PROTEIN%5D3_818 imgt:StudyProduct_09cb89dc-7fb2-3f6a-980e-48d78bdb7716|rdfs:label|StudyProduct_09cb89dc-7fb2-3f6a-980e-48d78bdb7716 _:B25cbfe1a6c0f1d4e0092355808805650|imgt:isDecisionOf|imgt:StudyProduct_a65d783c-20d7-3c58-a5b8-dff0787e156c imgt:Segment_233_1|rdf:type|imgt:Segment imgt:Product_8cbc64f1-a09e-3b24-8971-ec6382ae015a|imgt:isProducedBy|imgt:OncoMed_Pharmaceuticals imgt:5'KDE-3'KDE-JOINT|rdf:type|imgt:IntronConceptLabel imgt:Construct_1247|rdf:type|imgt:Construct _:B5e595980c6d9d0f6eae4c3a574e25f56|imgt:isDecisionOf|imgt:StudyProduct_773868e5-eff6-3aac-a866-62bdf844a898 imgt:StudyProduct_c0c3e436-3c22-3968-a5d0-efc387b4d777|rdf:type|obo:NCIT_C174271 pubmed:16699037|dc:contributor|Izumi Y imgt:StudyProduct_49630eff-3c50-36c8-b562-6cd7a15dde73|rdfs:label|StudyProduct_49630eff-3c50-36c8-b562-6cd7a15dde73 imgt:mAb_905|imgt:inn_name|tamrintamab imgt:Polymyositis|imgt:isClinicalIndicationOf|imgt:StudyProduct_133b632f-0805-34c9-91dc-d9bfcae1944b imgt:Segment_1234_1|rdf:type|imgt:Segment imgt:StudyProduct_6c042a80-99ac-3632-92c2-98656ca8f62e|imgt:hasClinicalIndication|imgt:Lupus_nephritis imgt:IgG4-lambda2_780|http://semanticscience.org/resource/SIO_000291|imgt:MASP2 imgt:StudyProduct_b1f755db-a205-37b9-a833-082549620702|rdf:type|obo:NCIT_C174271 imgt:Clone_1245|imgt:isOriginCloneOf|imgt:mAb_1245 imgt:mAb_1290|imgt:inn_number|11879 imgt:StudyProduct_e7a8bcac-b8ac-3439-9208-78e57898f5c8|rdfs:label|StudyProduct_e7a8bcac-b8ac-3439-9208-78e57898f5c8 imgt:Construct_304|rdfs:label|Construct_304 imgt:Product_36dae934-299e-3c35-a473-cb615954069c|imgt:commun_name|Factor VIII-XTEN imgt:Product_218005ef-16bd-34ee-970f-6ed51853e661|imgt:commun_name|NKTR-214 imgt:Vidara_Therapeutics_Ltd|rdfs:label|Vidara Therapeutics Ltd. imgt:IgG1-kappa_768|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:11348|rdfs:label|11348 imgt:StudyProduct_004cd2da-ac49-3ae9-a39b-84a0ad770ddb|imgt:hasExpressionSystem|imgt:_COS_cells_transient_expression imgt:Clone_182|obo:RO_0002162|imgt:Homsap imgt:Product_60bb6277-81d6-3efe-8951-bb967ff3ce28|imgt:hasStudyProduct|imgt:StudyProduct_997755ec-78d1-3d75-80b4-20ca997666bc imgt:9983|rdfs:label|9983 imgt:StudyProduct_92ec2139-e6cd-301c-9c7c-75b68c19bf4b|imgt:development_technology| Medarex’s UltiMAb® imgt:Cancers_squamous|rdf:type|obo:NCIT_C185637 imgt:D-J-C-SEQUENCE|rdf:type|imgt:PrototypeLabel imgt:Construct_892|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:mAb_1249|imgt:inn_number|12028 imgt:12044|rdf:type|obo:NCIT_C25402 _:B261109ae9fcd2e395c1a283e3f4e132e|imgt:isDecidedBy|imgt:FDA imgt:CJSC_Biocad|rdfs:label|CJSC Biocad imgt:Construct_298|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:C-CLUSTER|rdfs:label|C-CLUSTER imgt:StudyProduct_4809e2f0-a270-39eb-a913-7c592fd65ccc|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_6531837b-e221-3c84-b29d-98740ad35007|imgt:application_type|Therapeutic imgt:THPO_(thrombopoietin_megakaryocyte_growth_and_differentiation_factor_MPLLG_MPL_ligand_c-mpl_ligand_megakaryocyte_growth_and_development_factor_megakaryocyte_colony-stimulating_factor)_22-184_(P40225-1)|rdf:type|imgt:ConstructLabels imgt:StudyProduct_86415a3f-bfa4-310e-97f9-2fae4f934b54|imgt:hasClinicalIndication|imgt:Allergic_asthma imgt:mAb_328|imgt:inn_number|9116 _:B668e6ec25cbb82bd419cb4a5c6b1e048|rdf:type|obo:NCIT_C53285 imgt:Segment_200_1|obo:BFO_0000050|imgt:Construct_200 imgt:IgG4-kappa_402|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG4-kappa.png imgt:Segment_424_1|imgt:has_rank|1 imgt:StudyProduct_7a614fd0-6c32-3499-b168-0b9896beedeb|rdf:type|obo:NCIT_C174271 imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_d3a265a6-bed9-31df-b3db-036c7062c581 imgt:IgG1-kappa_374|rdf:type|imgt:MAbReceptor 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imgt:IgG2b-kappa-ricin_A_1092|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG2b-kappa-ricin%20A.png imgt:StudyProduct_26ff60fb-090b-332b-a751-9cfb2b0b6a2e|imgt:hasExpressionSystem|imgt:_Sp2/0_mouse_hybridoma_cells imgt:mAb_1250|imgt:inn_number|12017 imgt:FPIA_%5BPROTEIN%5D2-FC_1162|rdf:type|imgt:MAbReceptor imgt:StudyProduct_d8df10ca-44f2-3bd4-9c5d-3824aa605a4c|imgt:application_type|Therapeutic imgt:IgG1-kappa_1194|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:(scFv-kappa-heavy)-(scFv-heavy-kappa)|rdf:type|imgt:SegmentLabels imgt:mAb_67|imgt:clinical_trials|298 studies found, 28 recruiting pubmed:8798431|dc:contributor|Cruz GA imgt:StudyProduct_723687d1-7878-30f1-987e-b1bc5e2c19ec|imgt:hasClinicalPhase|imgt:Phase_II imgt:mAb_112|imgt:hasMabReceptor|imgt:IgM-nd_112 imgt:StudyProduct_910fdcc2-e291-3f1f-9bc5-5013d7e52310|imgt:hasDecision|_:B9f09bef5ecfb024e8df3be79e6f49508 imgt:Center_of_Molecular_Immunology_(CMI)|rdfs:comment|Havana , Cuba imgt:Product_c48dacde-0411-3136-a504-67d0e67b07e5|imgt:isProducedBy|imgt:Human_Genome_Sciences_Inc_(HGSI) imgt:Segment_1089_1|rdf:type|imgt:Segment imgt:Product_1eac0fc9-e051-34a3-b536-b2e4e0192fa3|rdfs:label|Product_1eac0fc9-e051-34a3-b536-b2e4e0192fa3 imgt:StudyProduct_f29346f3-33d7-390e-bd59-8bd7be027cfe|imgt:application_type|Therapeutic imgt:StudyProduct_c5762f39-ceaa-3bef-b2bc-1b12f751b0d8|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_c5ac7867-a692-3b88-8978-27c030921afe|imgt:application_type|Therapeutic imgt:IgG4-nd_279|imgt:isMabReceptorOf|imgt:mAb_279 imgt:StudyProduct_f7a6745b-24a9-360a-9e52-f65b1e5d89c3|imgt:hasClinicalPhase|imgt:Phase_I imgt:mAb_171|imgt:imgt_note| Origine clone from Cambridge Antibody Technology (CAT) library (Cambridge UK) In 2007, AstraZeneca bought MedImmune created in 1988. On Feb 14, 2019, it was announced that MedImmune will cease to exist as an industry name as the owner AstraZenaca has decided to retire the brand as part of ongoing restructuring efforts.https://www.biopharmadive.com/news/astrazeneca-retires-medimmune-name-amid-sales-turnaround/548489/ _:B0125e788dd8a580ea5a131d557c2b4d0|imgt:hasStatut|imgt:approval imgt:Construct_697|rdf:type|imgt:Construct imgt:StudyProduct_115bc04d-cd5b-3146-9ec7-c78e72875181|imgt:hasClinicalIndication|imgt:Solid_tumors imgt:IgG1-kappa-4cys-drug_493|rdf:type|imgt:MAbReceptor imgt:Human_Genome_Sciences_Inc_(HGSI)|imgt:produces|imgt:Product_d7fdef9d-ffc1-3cfa-a0c4-55b5452505c5 imgt:Product_4eeaa614-ef03-3234-84a9-d2d1c82a6455|imgt:hasStudyProduct|imgt:StudyProduct_e20403bd-7c3c-33eb-84b6-74e03b01492a imgt:Fab-Delta_Lambda|imgt:isDefinedBy|imgt:IG-Heavy-Delta-IGHD imgt:MAbReceptor_239|imgt:hasMolecularComponent|imgt:IG imgt:HiFiBiO_Therapeutics|rdfs:label|HiFiBiO Therapeutics imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_ab579b46-5b62-3349-b790-7a05c13bb56b imgt:Colitis_ulcerative_(UC)|imgt:isClinicalIndicationOf|imgt:StudyProduct_66007dfd-a14c-3ed3-98b8-c170f40ad8e0 imgt:FUSION-ACVR2B-GAMMA-1|rdfs:label|FUSION-ACVR2B-GAMMA-1 imgt:mAb_439|imgt:hasProduct|imgt:Product_4975e7ab-7850-3795-8d34-6526bce56205 imgt:Clone_235|rdfs:label|Clone_235 imgt:N-GLYCOSYLATION-SITE|rdfs:label|N-GLYCOSYLATION-SITE imgt:1MIM|rdf:type|obo:NCIT_C25402 imgt:Product_19035bc7-8361-3721-af18-5bc56c99124d|imgt:hasStudyProduct|imgt:StudyProduct_0d4702ea-d962-3cfe-994a-255a645af6e1 imgt:Product_92aaaa11-a012-35e5-91ee-9df570fa89a7|imgt:commun_name|CNTO 1275 imgt:StudyProduct_1a64ef25-30ed-3988-9d19-9bfcc5d21705|imgt:hasDecision|_:Bbe09eaeda9c719d931e6d4f6b4b67ee5 imgt:IgG4-kappa_807|obo:RO_0002162|imgt:Hum imgt:StudyProduct_578e7d79-47b0-3e26-be4a-bc9a9f72efe9|imgt:hasClinicalIndication|imgt:Cancers_prostate imgt:mAb_1190|rdf:type|obo:NCIT_C184863 imgt:Construct_594|rdf:type|imgt:Construct _:B0798134bf6f92e4647cb27459895158b|imgt:isDecidedBy|imgt:EMA imgt:mAb_446|rdf:type|obo:NCIT_C152151 imgt:Crohn's_disease_(CD)|imgt:isClinicalIndicationOf|imgt:StudyProduct_0e54bccd-7463-3c62-b3aa-f7ef86c2fb45 imgt:Segment_677_1|rdf:type|imgt:Segment imgt:StudyProduct_52aec5c4-8017-318a-be45-cf1c1533a0fa|rdfs:label|StudyProduct_52aec5c4-8017-318a-be45-cf1c1533a0fa imgt:StudyProduct_fc17d1f0-b127-3b8d-b372-34a39c1f9265|imgt:hasClinicalIndication|imgt:Psoriasis obo:NCIT_C182100|rdf:type|owl:Class imgt:Construct_368|imgt:isConstructOf|imgt:Fab-G1-kappa-%5BFc-G1%5D_368 imgt:Product_38467291-7ffe-3c19-9668-d0dbeafcd182|imgt:isProductOf|imgt:mAb_1296 imgt:StudyProduct_1bd034c3-034e-3ec1-99c5-e7a5d97ae863|rdfs:label|StudyProduct_1bd034c3-034e-3ec1-99c5-e7a5d97ae863 imgt:Clone_134|rdf:type|obo:NCIT_C37925 imgt:Segment_1041_1|imgt:hasImgtLabel|imgt:TR-Alpha_Beta-2 imgt:mAb_937|imgt:inn_recommended_list|83 (2020) 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imgt:StudyProduct_5b2accd7-abb8-3404-b64e-41d8677041ff|imgt:hasDecision|_:Bf7e99dd1871cc4c10252b06772add9aa imgt:Product_90f4823e-5cb9-333f-bd91-f83046626483|imgt:isProductOf|imgt:mAb_495 imgt:Segment_587_1|obo:BFO_0000050|imgt:Construct_587 imgt:Construct_667|obo:BFO_0000051|imgt:Segment_667_1 imgt:mAb_553|imgt:inn_recommended_list|75 (2016) imgt:mAb_854|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=854 imgt:IgG1-kappa_1215|imgt:hasMolecularComponent|imgt:IG _:B74f626a7adf08954d6755fdc1366fe00|imgt:isDecisionOf|imgt:StudyProduct_d09500bb-2347-3079-9934-c8bd743f9eeb imgt:Product_12e83c22-d0d4-30c2-8197-cc9eececef54|imgt:comercial_name|PegIntronTM imgt:StudyProduct_0e404088-fe07-3e25-8630-993e3507585c|imgt:hasClinicalIndication|imgt:Solid_tumors imgt:IgG1-lambda_1020|imgt:hasConstruct|imgt:Construct_1020 imgt:Solid_tumors|imgt:isClinicalIndicationOf|imgt:StudyProduct_033d3022-252a-3fe4-b6c7-ebde639ce973 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imgt:Product_3e72db9b-e1f8-3042-b36a-b6d976d78dba|imgt:isProductOf|imgt:mAb_262 imgt:StudyProduct_94f5337b-0646-3463-9f19-8108acffa52d|imgt:hasClinicalIndication|imgt:Lymphoma_diffuse_large_B_cell_(DLBCL) imgt:StudyProduct_9ff7f76b-6834-3a20-a391-b12d27fb1ff0|imgt:hasClinicalIndication|imgt:Rheumatoid_arthritis_(RA) imgt:Construct_393|imgt:hasImgtLabel|imgt:IGHG1_Fc_(Fragment_constant)-%5Bpeptide_14-mer-peptide_14-mer%5D2 imgt:StudyProduct_64ae4f5a-6e22-3dd8-8377-f95cecc297c6|imgt:isStudyProductOf|imgt:Product_950458ce-5b79-3a87-87fd-0d76107f13a3 imgt:Product_56576134-cfbd-35a6-b65a-05844543f13f|imgt:hasStudyProduct|imgt:StudyProduct_9bada0f9-48f1-338a-9830-59c351659204 imgt:Anthrax_inhalation|rdf:type|obo:NCIT_C185637 imgt:mAb_308|imgt:inn_proposed_list|80 (1998) imgt:mAb_1174|imgt:hasOriginClone|imgt:Clone_1174 imgt:Product_9644c27e-d6e1-34ac-b2e2-7fc4cdf6bc66|imgt:commun_name|VR-942 imgt:HTRA1|imgt:isTargetOf|imgt:Fab-G1-kappa_1169 imgt:Mesothelioma|imgt:clinical_domain|Oncology imgt:Segment_1179_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:StudyProduct_22103a77-55ac-3a6b-969c-686e568dfecb|rdfs:label|StudyProduct_22103a77-55ac-3a6b-969c-686e568dfecb imgt:StudyProduct_0cf110d5-c16d-3145-883f-5cb8cb26f2aa|imgt:hasClinicalIndication|imgt:Cancers_breast imgt:Segment_700_2|rdfs:label|Segment_700_2 imgt:TR-Delta-TRD|imgt:defines|imgt:TR-Gamma-5_Delta imgt:Product_e606b546-26e7-3e5c-961c-32e499a13320|imgt:comercial_name|STRENSIQ™ imgt:StudyProduct_48088129-f77a-30bd-b1af-d861ec4ac8bf|imgt:isStudyProductOf|imgt:Product_6ef331a9-b7c2-3835-b601-a1cdf2e62923 imgt:StudyProduct_5bd00c15-5132-3b98-92ad-994980aadd96|rdfs:label|StudyProduct_5bd00c15-5132-3b98-92ad-994980aadd96 imgt:Product_69f9aeb0-186e-34fb-829c-f2217552ddf1|imgt:isProductOf|imgt:mAb_389 imgt:Cancers_prostate|rdf:type|obo:NCIT_C185637 imgt:mAb_1156|rdf:type|imgt:INN imgt:mAb_630|imgt:inn_name|mipeginterferon alfa-2b imgt:Product_a3222722-cf6b-3189-8b44-5c791cff2a5e|imgt:commun_name|EMD 273066 imgt:mAb_856|imgt:inn_proposed_list|119 (2018) _:Bb24448a4cdbde72d92bb3d0a311f7370|imgt:hasStatut|imgt:approval imgt:%5BG1_VH-h-CH2-CH3%5D-dimer|rdf:type|imgt:ConstructLabels imgt:StudyProduct_0aca5178-6a90-387a-8990-1deac7a84c73|imgt:application_type|Therapeutic pubmed:1350088|dc:contributor|Henner D imgt:Product_e9e52bcc-24ec-39dc-8de4-b4ba591c6845|imgt:hasStudyProduct|imgt:StudyProduct_6bde1980-495c-3cc6-ad93-882c2bb2a125 imgt:Product_7bade22b-a6c5-3b9d-9336-099f730a41de|rdfs:label|Product_7bade22b-a6c5-3b9d-9336-099f730a41de imgt:IgG4-lambda_171|obo:RO_0002162|imgt:Homsap imgt:mAb_615|imgt:imgt_note| AMP-224 has a unique, non-blocking mechanism of action (MOA). It binds PD-1supHI/supB7-H1sup-/supT cells (chronically stimulated / exhausted T cells). Does not bind PD-1sup+/supB7-H1sup+/sup cells (normal activated T cells). Poster ASCO 2013. AMP-224 was developed by Amplimmune (Gaithersburg, MD, USA) founded in 2007. On October 4, 2013, AstraZeneca\\'s MedImmune LLC biologics unit acquired cancer immunotherapy company Amplimmune. In 2007, AstraZeneca bought MedImmune created in 1988. On Feb 14, 2019, it was announced that MedImmune will cease to exist as an industry name as the owner AstraZenaca has decided to retire the brand as part of ongoing restructuring efforts.https://www.biopharmadive.com/news/astrazeneca-retires-medimmune-name-amid-sales-turnaround/548489/ imgt:mAb_305|imgt:hasMabReceptor|imgt:IgG1-nd_MM_305 imgt:mAb_748|imgt:hasMabReceptor|imgt:IgG4-nd_748 imgt:Segment_240_1|rdfs:label|Segment_240_1 imgt:Product_80c5a255-5aa4-3782-9556-7a0618ee7c39|imgt:hasStudyProduct|imgt:StudyProduct_43c6a240-a4d7-3834-a62e-3bff5e8b3114 pubmed:18088084|dc:contributor|Nicolaides NC imgt:mAb_906|imgt:inn_recommended_list|82 (2019) imgt:mAb_216|imgt:centerwatch_link|http://www.centerwatch.com/drug-information/fda-approvals/drug-details.aspx?DrugID=737 imgt:StudyProduct_4bc6fe2a-8e1e-302f-9a0f-d3a9f0efffc6|imgt:hasClinicalPhase|imgt:Phase_I/II imgt:StudyProduct_94bed1e7-0c3a-3eb5-9087-72b06c2758dc|imgt:hasDecision|_:B5c8295b5f9ca49c820eda73b12b9b9a2 imgt:CPCA_three-helical_bundle_1053|rdfs:comment|CPCA_three-helical bundle imgt:MUC1_sialylated_carbohydrate_tumour-associated|obo:RO_0002162|imgt:Homsap imgt:IgG1-kappa_1171|imgt:isMabReceptorOf|imgt:mAb_1171 _:B0cf5d79f6c48f898d1f188e28f4fa573|imgt:isDecidedBy|imgt:FDA imgt:StudyProduct_feb2b884-1e28-3cf6-b19a-b46c52cca30a|rdf:type|obo:NCIT_C174271 imgt:Product_f4dda718-cf10-3efb-a60a-ef580f59896d|imgt:commun_name|EX 14870 imgt:ADCYAP1R1|imgt:isTargetOf|imgt:IgG1-kappa_978 imgt:StudyProduct_8dcdbc19-94fa-3962-86c1-8bf267c075df|rdfs:label|StudyProduct_8dcdbc19-94fa-3962-86c1-8bf267c075df imgt:StudyProduct_48088129-f77a-30bd-b1af-d861ec4ac8bf|rdfs:label|StudyProduct_48088129-f77a-30bd-b1af-d861ec4ac8bf _:B5ed9d6367100d1979e91d8039ba61b0d|dc:date|2017-02-06 imgt:mAb_1211|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=1211 imgt:IgG1-kappa_1104|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:HTRA1|rdf:type|obo:NCIT_C25702 _:B746ac5bd753c0eedf43618f31eaf4fe9|imgt:isDecisionOf|imgt:StudyProduct_206ad344-2ed9-380f-bfc1-5aa8d9191483 obo:GENO_0000408|rdfs:label|isAlleleOf imgt:HIV-1|imgt:isTargetOf|imgt:IgG1-kappa_1209 imgt:Product_540b3929-a375-3db7-8982-d2f9143d05ad|imgt:hasStudyProduct|imgt:StudyProduct_d2145a16-62dc-3c18-906f-9edcf621d667 imgt:mAb_624|rdfs:label|mAb_624 imgt:FPIALabel|rdfs:label|FPIALabel imgt:StudyProduct_ef3d9b0a-7bcf-3f8e-b7f4-7c0f3bc47e65|imgt:isStudyProductOf|imgt:Product_7ce2f7b8-fb77-36e0-89f8-7a6d2aa437ac imgt:10652|rdf:type|obo:NCIT_C25402 imgt:IgG1-lambda_1109|http://semanticscience.org/resource/SIO_000291|imgt:Severe_acute_respiratory_syndrome_coronavirus_2_(SARS-CoV-2) imgt:Construct_680|rdf:type|imgt:Construct imgt:IgG1-nd_72|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-nd.png imgt:mAb_1111|imgt:hasProduct|imgt:Product_1f864c32-9353-3a93-8c8b-c41e0f2b9f98 imgt:Product_2527517c-0a7a-3f6a-b4c5-fff6e5f2d499|rdfs:label|Product_2527517c-0a7a-3f6a-b4c5-fff6e5f2d499 imgt:Product_39647f9c-5a2a-3d4d-b584-bce5721f1fed|imgt:hasStudyProduct|imgt:StudyProduct_f8872358-c5ae-3d19-aa7e-89ec0f830df2 imgt:mAb_165|imgt:inn_number|7860 imgt:StudyProduct_bdfc03ae-258c-35c5-944d-ccc2478989da|imgt:hasClinicalIndication|imgt:Cancers_pancreatic imgt:scFv-kappa-heavy-CD28_(CO-TM-CY)-CD247_827|imgt:isMabReceptorOf|imgt:mAb_827 imgt:StudyProduct_4ceeafbd-cd1c-3ed8-9980-a390e57b69f6|imgt:hasClinicalPhase|imgt:Phase_II imgt:StudyProduct_6ee58395-ba07-36f4-abe7-f7b57669944c|imgt:application_type|Therapeutic imgt:Product_20fcba1e-a0bb-3838-8745-6c6f5da541f2|imgt:isProducedBy|imgt:Genmab_A/S imgt:Clone_212|rdf:type|obo:NCIT_C37925 obo:NCIT_C170329|rdf:type|owl:Class imgt:BTLA|rdf:type|imgt:RPILabel imgt:Product_e96e8627-0681-30c2-9863-debf929a349d|imgt:comercial_name|RYBREVANT™ imgt:Segment_1092_1|rdf:type|imgt:Segment imgt:LILRB1|skos:definition|Leukocyte immunoglobulin-like receptor subfamily B member 1 imgt:Clone_235|obo:RO_0002162|imgt:Ratsp. imgt:IgG1-lambda_426|obo:RO_0002162|imgt:Homsap imgt:Segment_1022_1|imgt:hasImgtLabel|imgt:IgG1-lambda imgt:IgG1-kappa-4cys-drug_721|imgt:hasConstruct|imgt:Construct_721 imgt:IgG1-kappa-4F_1266|rdf:type|imgt:MAbReceptor imgt:mAb_354|imgt:hasProduct|imgt:Product_20fcba1e-a0bb-3838-8745-6c6f5da541f2 imgt:IgG1-kappa_1035|rdfs:comment|IgG1 - kappa imgt:mAb_1086|imgt:hasImgtStructureEntry|imgt:11467 _:B43b7d374858e7912ceb10f9e07cfa87f|imgt:hasDesignation|imgt:Orphan_drug imgt:VH-VH_672|imgt:hasConstruct|imgt:Construct_672 imgt:StudyProduct_7d267f09-5c2d-385e-9f8e-59d3f4aafe63|rdfs:label|StudyProduct_7d267f09-5c2d-385e-9f8e-59d3f4aafe63 imgt:IgG4-kappa_483|rdf:type|imgt:MAbReceptor imgt:Construct_40|obo:BFO_0000051|imgt:Segment_40_1 _:Bde3ad9e05eb510f656bcf39f94d4efb9|rdf:type|obo:NCIT_C53285 imgt:mAb_915|imgt:hasProduct|imgt:Product_1c004b38-ab4d-3414-acd3-4ffa3acf8432 imgt:Telangiectasia_hereditary_haemorrhagic_(HHT)|imgt:clinical_domain|Cardiology imgt:StudyProduct_bd276df3-9f9e-34f3-add1-266cb6c98abe|imgt:application_type|Therapeutic imgt:mAb_627|imgt:inn_number|7909 imgt:IL13|rdf:type|obo:NCIT_C25702 imgt:Product_d897727a-4fb2-3eb1-99b5-48e3b1af7b74|imgt:commun_name|SHR-1210 imgt:mAb_349|imgt:inn_proposed_list|103 (2010) imgt:Construct_898|imgt:isConstructOf|imgt:IgG4-kappa_898 imgt:mAb_764|imgt:inn_name|berlimatoxumab imgt:Product_0c5fb596-41fb-3ab4-bbc2-3ab6a19b5b7e|imgt:commun_name|coagulation Factor IX [Recombinant] imgt:scFv-scFv-scFc_kappa-lambda_1055|imgt:hasConstruct|imgt:Construct_1055 imgt:StudyProduct_c0c3e436-3c22-3968-a5d0-efc387b4d777|imgt:isStudyProductOf|imgt:Product_4a5c4039-6661-3fa4-a1ee-9a7e6ff795b2 imgt:Product_9b8fd23d-77df-3897-9633-83ec58c245d0|imgt:comercial_name|ADBRY™ imgt:Product_0c9f5d50-b81e-3ee8-93bc-e8be40fcc398|imgt:comercial_name|LAROFERON imgt:mAb_1118|imgt:hasMabReceptor|imgt:IL2-IL2-IL2RA_1118 imgt:Wilex_AG|rdf:type|obo:NCIT_C54131 imgt:mAb_196|imgt:hasProduct|imgt:Product_de6b73a9-944b-34bc-ad4c-f6cbd43ea96a imgt:RSV|skos:definition|RSV (respiratory syncytial virus) imgt:mAb_1280|rdfs:label|mAb_1280 obo:NCIT_C166879|rdfs:subClassOf|obo:NCIT_C1909 imgt:Product_d51c7a19-f660-3ffb-8ce3-c176dfe0b4d7|imgt:hasStudyProduct|imgt:StudyProduct_e89ce4e2-c1fe-3695-b4a5-5397d1914039 _:B10a13de8fe2d90157c0734dfcc7242de|imgt:isDecisionOf|imgt:StudyProduct_9a7a6532-3f44-3fdc-becf-191b4f94dcc5 imgt:StudyProduct_788c17fd-ae90-3f97-b8b8-0976786b20e7|imgt:development_technology| Abgenix's XenoMouse® imgt:Product_bfe41bf2-718f-3803-b385-cfc07fd9645d|imgt:hasStudyProduct|imgt:StudyProduct_21b1c5a4-0f90-32a1-ad7b-f5dc913800a5 imgt:StudyProduct_7db4409b-932c-3b0e-98bc-041e914b8692|rdf:type|obo:NCIT_C174271 pubmed:8931129|dc:contributor|Searle SM imgt:mAb_344|rdfs:label|mAb_344 imgt:Polyarticular_Juvenile_Idiopathic_Arthritis_(PJIA)|imgt:isClinicalIndicationOf|imgt:StudyProduct_cfcfdb97-fa02-3890-8459-d5defed66faa imgt:Construct_838|imgt:hasImgtLabel|imgt:(scFv-heavy-kappa)-(scFv-heavy-lambda) imgt:StudyProduct_85681a62-3f0c-3e0d-a4db-876fd563c5ec|rdf:type|obo:NCIT_C174271 imgt:IgG4-kappa_483|obo:RO_0002162|imgt:Homsap imgt:Construct_220|obo:BFO_0000051|imgt:Segment_220_1 imgt:mAb_462|imgt:atc_link|http://www.whocc.no/atc_ddd_index/?code=V03AB37 imgt:IgG1-nd_840|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-nd.png imgt:mAb_661|imgt:inn_number|10418 imgt:Locus|owl:disjointWith|obo:NCIT_C164455 imgt:mAb_801|imgt:inn_number|10730 imgt:Product_64d31d25-899a-3941-a5d0-bc3b3c0b468b|imgt:commun_name|AMG-282 imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_66f95757-979d-33b3-8aec-fb76b3c73d96 imgt:scFv-kappa-heavy-CD3E_(CO-TM-CY)_1300|obo:RO_0002162|imgt:Chi imgt:StudyProduct_2b14bfff-9798-340b-b834-432071918ab6|imgt:application_type|Therapeutic imgt:Product_38366130-a996-3336-8943-ab4efcfb1fbc|imgt:commun_name|enfortumab vedotin-ejfv _:Bb7a48a2b380d3264a8bad2536a1de264|dc:date|2019-10-07 imgt:Construct_915|imgt:hasImgtLabel|imgt:IgG4-lambda imgt:Segment_99_1|obo:BFO_0000050|imgt:Construct_99 imgt:Clone_585|obo:RO_0002162|imgt:Musmus imgt:mAb_1023|imgt:hasMabReceptor|imgt:IgG1-kappa_1023 imgt:10882|imgt:isImgtStructureEntryOf|imgt:mAb_783 imgt:Diabetic_nephropathy|rdfs:label|Diabetic_nephropathy imgt:Product_d7375334-d0db-32f3-81ba-3cfa540a5cf4|imgt:hasStudyProduct|imgt:StudyProduct_a4727270-51a2-39ad-a4c3-e1c0fa7af61a imgt:Segment_1118_3|imgt:hasImgtLabel|imgt:IL2RA imgt:Segment_673_2|rdf:type|imgt:Segment imgt:mAb_629|imgt:inn_name|ropeginterferon alfa-2b imgt:Product_7afcc8b3-764f-3d4d-9070-eb5b2b97002f|rdfs:label|Product_7afcc8b3-764f-3d4d-9070-eb5b2b97002f _:Bfe857a5832c9a8893003dc1ec40bc432|rdf:type|obo:NCIT_C53285 imgt:11886|imgt:isImgtStructureEntryOf|imgt:mAb_1233 imgt:Product_7fff9d3d-ea92-356d-86ba-ac6cbbbf10dd|rdf:type|obo:NCIT_C51980 imgt:IgG1-kappa_1036|rdfs:label|IgG1-kappa_1036 imgt:Product_981dc5f1-b82e-3839-b7ef-ffb6e029ad46|rdf:type|obo:NCIT_C51980 imgt:F12|skos:definition|F12 (coagulation factor XII (Hageman factor)) imgt:CD22|imgt:isTargetOf|imgt:Fab%27-G2a-kappa_306 imgt:ALB-Tn3(2)_1116|obo:RO_0002162|imgt:syncon imgt:FOLH1|imgt:isTargetOf|imgt:MAbReceptor_513 imgt:Antiphospholipid_syndrome_(APS)|imgt:isClinicalIndicationOf|imgt:StudyProduct_e56ab5b1-3248-3291-b805-2ba2f0c9b846 obo:NCIT_C102784|rdfs:subClassOf|obo:NCIT_C1909 imgt:Product_8ce04d69-ff3a-3c28-a88f-ba8875ab2e2a|imgt:commun_name|CD38-Attenukine imgt:StudyProduct_8884105a-95a2-34a2-9f41-9dd1caaf8643|rdfs:label|StudyProduct_8884105a-95a2-34a2-9f41-9dd1caaf8643 imgt:Product_710cc786-b093-3241-ad04-1d69bb1caaf0|imgt:hasStudyProduct|imgt:StudyProduct_2523ae41-58c5-34a2-a352-75ae04be2b97 imgt:StudyProduct_4eb8a332-ece7-382c-8149-c69ae3f2d44f|imgt:isStudyProductOf|imgt:Product_508ac5a4-d670-3d35-8997-671e58d97871 imgt:Product_e40335c6-1d9d-3d4d-b9fe-75c1775c1450|imgt:isProductOf|imgt:mAb_667 imgt:Segment_938_1|imgt:has_rank|1 imgt:IgG4-kappa_962|http://semanticscience.org/resource/SIO_000291|imgt:CD3E imgt:IgG2a-kappa-G2b-lambda_218|obo:RO_0002162|imgt:Musmus imgt:Product_684bea4e-8e04-3000-b35f-cff891c612da|imgt:isProducedBy|imgt:Novartis_Pharmaceuticals_Corp imgt:StudyProduct_4be745c4-3084-3be0-bc46-8406ddd707b1|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:PDCD1|imgt:isTargetOf|imgt:IgG4-kappa_968 imgt:Product_c5ef56a8-976b-3908-a950-7c23335315c5|imgt:comercial_name|ZMapp™ imgt:StudyProduct_0d4702ea-d962-3cfe-994a-255a645af6e1|imgt:hasClinicalIndication|imgt:Cancers_colorectal_(CRC) imgt:Product_1814bcd8-3086-35ba-9fec-07ef12678af1|imgt:commun_name|hBS910 imgt:CPCA_PROTEIN-FC_819|http://semanticscience.org/resource/SIO_000291|imgt:GHR imgt:StudyProduct_15a257d3-e7cf-393d-9482-4fadc2a060bb|imgt:application_type|Therapeutic imgt:StudyProduct_21694c6c-877e-3426-8dc2-a88c164223db|imgt:isStudyProductOf|imgt:Product_251879e5-8c72-335f-89ef-7f76ad06fea2 imgt:IgG1-kappa-4cys-drug_532|imgt:hasConstruct|imgt:Construct_532 imgt:Construct_726|obo:BFO_0000051|imgt:Segment_726_1 imgt:mAb_684|imgt:inn_name|somatropin imgt:Psoriasis|imgt:isClinicalIndicationOf|imgt:StudyProduct_59edc1c8-0af5-39b0-9197-e5eeadad6f19 imgt:StudyProduct_6e5f2ee6-162d-347d-a21a-5935fa70bf14|rdfs:label|StudyProduct_6e5f2ee6-162d-347d-a21a-5935fa70bf14 imgt:Product_afbf7fd5-a1d9-3e32-a5a3-10bbf3a99dee|imgt:isProductOf|imgt:mAb_298 _:B24ee16b030df15184ba87c431511df5b|imgt:isDecisionOf|imgt:StudyProduct_df49bbb4-57e9-326f-96b3-7785919c313d imgt:IgG1-kappa-4cys-drug_482|imgt:via_a| cleavable maleimidocaproyl-valyl-citrullinyl-p-aminobenzyloxycarbonyl (mc-val-cit-PABC) type linker imgt:mAb_49|imgt:hasMabReceptor|imgt:IgG1-nd_49 imgt:5'D-NONAMER|skos:definition|9 nucleotide recombination site like 'ggtttttgt', part of a 5'D-RS, in germline gDNA, or in germline or partially-rearranged cDNA _:Bfe74fdc482894a7db75c080addf7c396|imgt:hasDesignation|imgt:Orphan_drug imgt:IgG4-kappa_402|imgt:isMabReceptorOf|imgt:mAb_402 imgt:C5|imgt:isTargetOf|imgt:IgG1-kappa_783 imgt:mAb_1055|imgt:hasProduct|imgt:Product_467035a4-5e99-3c73-80a8-3bde5e974c48 imgt:Kenta_Biotech_Ltd|imgt:produces|imgt:Product_dd7c53c2-e62e-38a6-89d3-770f9d73c78c imgt:mAb_1085|imgt:hasImgtStructureEntry|imgt:11466 imgt:StudyProduct_b2fe6b3e-01db-34fc-be38-60a96062f2fd|imgt:hasClinicalIndication|imgt:Axial_spondyloarthritis_(axSpA) imgt:IgG1-nd_45|rdfs:label|IgG1-nd_45 imgt:herzuma™|rdfs:comment| HERZUMA™ (trastuzumab CT-P6 CT-P06) developed by Celltrion Inc. (Incheon Korea) approved in Korea (MFDS) on January 15 2014 approved in Canada on September 10 2019. Same clinical indications as HERCEPTIN®. imgt:StudyProduct_bdb855d2-1971-3748-84d7-811750a7c365|rdfs:label|StudyProduct_bdb855d2-1971-3748-84d7-811750a7c365 imgt:mAb_92|imgt:inn_name|teplizumab imgt:Product_485d748c-9ee2-352a-aaf4-3297a649c274|imgt:hasStudyProduct|imgt:StudyProduct_40fc8ece-1fab-3e40-9011-12e54af47f13 imgt:VH-VH%27-H-Gamma1-VL-VL%27-C-kappa_517|imgt:hasConstruct|imgt:Construct_517 imgt:Segment_794_1|imgt:has_rank|1 imgt:mAb_171|rdfs:label|mAb_171 imgt:PROTEIN_1DOMAIN-PEG_1299|imgt:hasConstruct|imgt:Construct_1299 imgt:mAb_753|imgt:inn_proposed_list|117 (2017) imgt:StudyProduct_a7f41f29-9e48-3863-a476-6400dc9dfac4|imgt:hasDecision|_:Bf58573117a767aa72045113d2934179b imgt:Product_c85dbcd7-b2a5-315e-880f-d1ba52bd5d6c|imgt:commun_name|NN-8765 imgt:Construct_1289|rdf:type|imgt:Construct imgt:G1-kappa_scFv-h-CH2-CH3_1083|rdfs:label|G1-kappa_scFv-h-CH2-CH3_1083 imgt:Product_f1ec19af-7de9-3338-a0c4-5659cd375377|rdf:type|obo:NCIT_C51980 imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_b9c1c916-5714-3827-9cc3-e400f7b2e42c _:Bb5d87ce371271b8c02e253226f545365|imgt:hasStatut|imgt:approval imgt:Lymphoma_diffuse_large_B_cell_(DLBCL)|imgt:isClinicalIndicationOf|imgt:StudyProduct_a4c07e51-096f-375a-9089-19e379332867 imgt:IgG1-nd_49|imgt:isMabReceptorOf|imgt:mAb_49 _:B93f2b5a64d2ab51e86e6b08449fdd9a9|imgt:isDecidedBy|imgt:FDA imgt:mAb_109|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=109 imgt:mAb_645|rdf:type|imgt:INN imgt:FPIA_%5BPROT-PROT%5D2-FC_615|http://semanticscience.org/resource/SIO_000291|imgt:PDCD1 imgt:StudyProduct_8d7975cb-13e4-34b9-80f4-71a0cba59723|imgt:application_type|Therapeutic imgt:Construct_956|obo:BFO_0000051|imgt:Segment_956_1 imgt:VPREB1_IGLL1|rdfs:label|VPREB1_IGLL1 imgt:StudyProduct_a4c07e51-096f-375a-9089-19e379332867|imgt:hasClinicalPhase|imgt:Phase_II imgt:Construct_744|obo:BFO_0000051|imgt:Segment_744_1 imgt:Product_8e8a1379-1ce0-3a6f-bd30-ded74b8a8b53|imgt:hasStudyProduct|imgt:StudyProduct_3e8a1cc1-7db6-3b17-a247-0d25e03076e5 imgt:IgG1-kappa_1122|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:FUSION-F10-GAMMA1|rdfs:label|FUSION-F10-GAMMA1 imgt:IFNAR2|imgt:isTargetOf|imgt:MAbReceptor_622 imgt:IgG1-kappa_1120|obo:RO_0002162|imgt:Homsap imgt:mAb_1169|imgt:inn_number|11632 imgt:9185|rdfs:label|9185 imgt:Segment_389_1|imgt:hasImgtLabel|imgt:IgG4-kappa imgt:IgG4-kappa_1211|imgt:hasMolecularComponent|imgt:IG _:B66acb3186743dde31b4a1144c779a59b|dc:date|2016-07-27 obo:NCIT_C174931|rdfs:subClassOf|obo:NCIT_C1909 imgt:StudyProduct_92fa5e3e-ae62-31a2-939f-aab0c6095c4b|imgt:isStudyProductOf|imgt:Product_dcf2f323-352b-3484-abe2-f1687814dc60 _:B2f6ed5ca07d7f567c9f389a41f260016|imgt:isDecisionOf|imgt:StudyProduct_a6f45061-c9c7-3e16-9147-26b49563e46b imgt:StudyProduct_af68e858-94af-390a-8590-75fd4e9f358e|rdf:type|obo:NCIT_C174271 imgt:mAb_272|imgt:inn_name|aselizumab imgt:Product_a67505b3-33ab-373f-8cc4-0f19a5a0e8ab|imgt:hasStudyProduct|imgt:StudyProduct_b95b0186-bd43-39ff-8924-e9e5390db2ff imgt:StudyProduct_3d94e0a5-599b-32e8-96c3-26e178605197|rdfs:label|StudyProduct_3d94e0a5-599b-32e8-96c3-26e178605197 imgt:IgG4-kappa_942|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG4-kappa.png imgt:Cardiovascular_thrombosis|rdfs:label|Cardiovascular_thrombosis imgt:StudyProduct_dfb01347-79d7-3f8d-b192-1e95a225d3c4|imgt:isStudyProductOf|imgt:Product_7547be12-737a-3e6a-82f2-436c48142632 imgt:mAb_914|imgt:hasImgtStructureEntry|imgt:10995 imgt:GlaxoSmithKline|imgt:produces|imgt:Product_b14b8aa8-e5fd-36c2-a182-be2c0d32c945 imgt:Product_90b985a1-c752-3673-801f-841c91bb6278|imgt:comercial_name|APAGIN imgt:MAbReceptor_59|obo:RO_0002162|imgt:Hum imgt:StudyProduct_fb299b3f-f4d1-3b52-8f3a-47cc96451ce5|imgt:hasClinicalIndication|imgt:Severe_acute_respiratory_syndrome_coronavirus_2_(SARS-CoV-2)_infection_(COVID-19) imgt:Product_3c4a9900-15e9-3b91-a699-2014802dc816|imgt:isProductOf|imgt:mAb_275 imgt:StudyProduct_664d9ecb-1e7e-3a5b-a985-b08289096f29|imgt:hasDecision|_:B5ab461e397ed4a016280ed728d22e555 imgt:Product_6921438e-7c6b-3e42-bd7f-0e3bc47d6848|rdfs:label|Product_6921438e-7c6b-3e42-bd7f-0e3bc47d6848 imgt:Segment_569_1|obo:BFO_0000050|imgt:Construct_569 imgt:StudyProduct_961a8cbb-97f6-330d-a900-59d58ea33047|imgt:hasDecision|_:Be6f3af41cb2872bcb5d61505560ea38d imgt:StudyProduct_2e1627be-7d57-3081-b019-6d6815084712|imgt:development_technology| Human antibody phage display library imgt:Product_31913cee-6bf1-33ef-9a45-4d5a8f0a7f07|rdfs:label|Product_31913cee-6bf1-33ef-9a45-4d5a8f0a7f07 imgt:mAb_19|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=19 imgt:IgG1-kappa_605|imgt:isMabReceptorOf|imgt:mAb_605 imgt:IgG2-kappa-4cys-drug_772|rdf:type|imgt:MAbReceptor imgt:mAb_40|imgt:hasProduct|imgt:Product_a75e30cc-34a4-3dcd-be39-36d249d9bb92 imgt:shiga_toxin_type_2|imgt:isTargetOf|imgt:IgG1-kappa_460 imgt:IgG4-kappa_863|rdfs:label|IgG4-kappa_863 imgt:mAb_1084|rdf:type|imgt:INN imgt:mAb_433|imgt:hasProduct|imgt:Product_5165f95d-de70-3e0c-9a9c-2a9dd0889401 imgt:Construct_824|imgt:hasImgtLabel|imgt:IGHG1_Fc_(Fragment_constant)-%5BIL2_(interleukin_2_IL-2)%5D2 imgt:Construct_102|obo:BFO_0000051|imgt:Segment_102_1 imgt:Construct_116|imgt:hasImgtLabel|imgt:IgG2-kappa imgt:mAb_1266|imgt:imgt_note| XpressCF® technology, developed by Sutro Biopharma, provides a cell-free bacterial expression for therapeutic proteins. XpressCF® also enables a non-natural amino acid conjugation technology XpressCF+™. The Fc is aglycosylated. imgt:MAbReceptor_736|http://semanticscience.org/resource/SIO_000291|imgt:ERBB2 imgt:Segment_631_1|rdf:type|imgt:Segment imgt:IgM_Iota-4|imgt:isDescribedBy|imgt:IG-MU_IOTA-1 pubmed:20848453|dc:contributor|Dijkstra G obo:NCIT_C174944|rdf:type|owl:Class imgt:mAb_1125|rdfs:label|mAb_1125 imgt:IgG1-kappa_958|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:StudyProduct_b8d27e6b-3e65-397a-be65-a52394b34b40|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:IgG1-kappa-1lys-drug_1285|rdfs:comment|IgG1-kappa-1lys-drug imgt:Product_fe4f62af-c472-3818-8fe1-ff947cd6497c|imgt:isProductOf|imgt:mAb_739 imgt:StudyProduct_f3630f74-f953-395b-93d3-1119b53391a6|imgt:application_type|Therapeutic _:Bf01397a08755b2e5599f218c75e1236c|imgt:isDecidedBy|imgt:FDA imgt:StudyProduct_aaf88d47-e347-3a74-85df-c908aa9bede9|imgt:hasClinicalPhase|imgt:Phase_I imgt:StudyProduct_50560455-18be-3aa0-a51c-8721a7c66c11|rdfs:label|StudyProduct_50560455-18be-3aa0-a51c-8721a7c66c11 pubmed:7858182|dc:contributor|Rao PE imgt:Segment_644_1|rdf:type|imgt:Segment imgt:Segment_429_1|imgt:hasImgtLabel|imgt:%5BV-kappa%5D2-Fc imgt:8598|rdfs:label|8598 imgt:VZV_(envelope_glycoprotein_H)|obo:RO_0002162|imgt:Humalp3 imgt:StudyProduct_8adbb782-4619-32a3-9dc4-7daef2f29f39|imgt:isStudyProductOf|imgt:Product_f4071a62-44ea-3bb4-9bb6-5c68735042f7 imgt:10165|rdfs:label|10165 imgt:F(ab’)2-Alpha_Lambda|rdfs:label|F(ab’)2-Alpha_Lambda imgt:IgG4-nd_442|obo:RO_0002162|imgt:Homsap imgt:mAb_71|imgt:imgt_note| ALLOMUNE™ : Orphan Drug Designation in combination with (non-myeloablative) allogenic bone marrow transplantation In 2007, AstraZeneca bought MedImmune created in 1988. On Feb 14, 2019, it was announced that MedImmune will cease to exist as an industry name as the owner AstraZenaca has decided to retire the brand as part of ongoing restructuring efforts.https://www.biopharmadive.com/news/astrazeneca-retires-medimmune-name-amid-sales-turnaround/548489/ imgt:Product_73a2400a-b469-322f-a790-9bf7a108b9d8|rdf:type|obo:NCIT_C51980 imgt:Product_8f121ce0-7d74-317e-8b1f-21d122e04521|imgt:commun_name|B-E8 imgt:IgG1-nd_67|rdf:type|imgt:MAbReceptor imgt:StudyProduct_3d57ba3d-0057-3447-b98c-41cae08f98b2|imgt:isStudyProductOf|imgt:Product_b6db4dcb-3841-3302-afce-13d1e43b067e imgt:IgG1-kappa_1271|rdfs:comment|IgG1 - kappa imgt:Product_33c97ddf-49a2-3444-885e-824d06bac68c|rdfs:label|Product_33c97ddf-49a2-3444-885e-824d06bac68c imgt:Construct_141|rdfs:label|Construct_141 imgt:IG-Light-Lambda-IGL|imgt:defines|imgt:IgG2c_Lambda imgt:10769|imgt:isImgtStructureEntryOf|imgt:mAb_814 imgt:IgG1-kappa_1133|imgt:hasConstruct|imgt:Construct_1133 imgt:StudyProduct_d51f2da4-db5f-3ef5-be58-0680a7bca194|imgt:hasClinicalIndication|imgt:Hemophilia_B_(control_and_prevention_of_bleeding_episodes) imgt:Alternative_to_antigen_receptors_(domain_scaffold:_ANK_ankyrin_repeats)-pegol|imgt:construction_detail|Conjugate - Alternative to antigen receptors (domain scaffold: ANK, ankyrin repeats) - pegol imgt:Construct_556|rdf:type|imgt:Construct imgt:StudyProduct_49e8d5cc-d97b-3254-9441-7552e198c97d|rdfs:label|StudyProduct_49e8d5cc-d97b-3254-9441-7552e198c97d imgt:9128|imgt:isImgtStructureEntryOf|imgt:mAb_301 imgt:mAb_403|imgt:imgt_note| ImClone Systems became a wholly-owned subsidiary of Eli Lilly and Company on November 24, 2008. Press release imgt:StudyProduct_988f16a7-b509-3d22-868d-d5da13250685|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_32ca3e79-d321-3d7a-85a7-31eebcc38bf8|imgt:application_type|Therapeutic imgt:F(AB%27)2-EPSILON_LAMBDA|rdf:type|imgt:IGProteolyticFragmentLabel imgt:TNFRSF4|rdfs:label|TNFRSF4 obo:NCIT_C166475|rdf:type|owl:Class imgt:ExeVir|imgt:produces|imgt:Product_aec98c23-c599-3342-9e7b-b9e6f0b64095 imgt:Product_3be9932d-5ca6-3496-9afa-cc3cf10e2e4d|imgt:hasStudyProduct|imgt:StudyProduct_aec72b5b-969b-3486-a11b-fe905a7ecdb7 imgt:mAb_545|imgt:inn_name|istiratumab imgt:IgG4-kappa_609|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG4-kappa.png imgt:11467|imgt:isImgtStructureEntryOf|imgt:mAb_1086 imgt:APP|imgt:isTargetOf|imgt:IgG1-Fab-kappa-lambda_1286 imgt:Construct_1235|obo:BFO_0000051|imgt:Segment_1235_1 imgt:Rheumatoid_arthritis_(RA)|imgt:isClinicalIndicationOf|imgt:StudyProduct_2a973a1a-e37f-35eb-9dc5-08529b842cc7 imgt:CD15|rdf:type|obo:NCIT_C25702 imgt:Product_a22e1e73-39c4-3d58-810c-61a5fe2f2b92|imgt:commun_name|SI-B001 imgt:Product_00ade453-d15c-3978-9598-f6299449d14e|imgt:isProducedBy|imgt:EUSA_Pharma imgt:CRM197_%5BPEP%5D15|skos:definition|Action of VAC at the μ-opiate receptor imgt:StudyProduct_f0f33bd5-8f18-36e2-97c2-5f7c94332ea9|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_f2011b88-e166-3b82-a33b-c06ed4f1f95a|imgt:hasClinicalIndication|imgt:Asthma imgt:mAb_264|imgt:imgt_note| The myristoyl group allows anchoring in the membrane of epithelial and endothelial cells of transplanted organs. Used for renal transplantation in perfusion of organs during the transfer from the donor to the recipient (MRC, King's College London) imgt:Zaire_Ebola_virus|imgt:isTargetOf|imgt:IgG1-kappa_728 imgt:Product_e8b11d66-dff7-3eda-b238-320ea0e901eb|imgt:isProductOf|imgt:mAb_717 _:B3f22013ecadccdd574074573031b98f3|imgt:isDecidedBy|imgt:FDA imgt:bispecific|imgt:isTargetOf|imgt:VH-VH%27-h-CH2-CH3_1127 imgt:StudyProduct_c6266a1e-643f-38b6-8f08-90e022c9365a|imgt:isStudyProductOf|imgt:Product_04ff78f3-f5e6-3084-a13e-fe88238ffe09 imgt:StudyProduct_f293da32-20d7-3f78-aa0c-d0d12e5145e8|rdf:type|obo:NCIT_C174271 imgt:Construct_151|obo:BFO_0000051|imgt:Segment_151_1 imgt:Product_b994b085-bbaa-3996-8731-aaa92b1466d1|imgt:isProductOf|imgt:mAb_327 imgt:IgG1-kappa_677|imgt:hasMolecularComponent|imgt:IG _:B54502329a7281b700e04b1024a9c093c|imgt:isDecisionOf|imgt:StudyProduct_165a82e1-b3b3-3d74-8e9b-63f471a1f450 imgt:IgG1-kappa_461|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:Segment_1217_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:IGKC|rdfs:label|IGKC imgt:Genentech_Inc|imgt:produces|imgt:Product_f5eb8070-c0e6-3c90-8a3e-0480be89ee9b imgt:Product_8bc22827-09a3-3eb0-9e53-3f97c122310c|rdf:type|obo:NCIT_C51980 _:B6886783945eae3db669739626afc4c70|imgt:isDecidedBy|imgt:FDA imgt:mAb_413|imgt:inn_number|9583 imgt:StudyProduct_d21fbd7e-727a-3e75-8765-e89276b143ab|rdf:type|obo:NCIT_C174271 imgt:Product_480f91be-f048-34a5-9224-9a68a0291dd8|imgt:commun_name|L22-Fc imgt:StudyProduct_577f4c82-90c0-3ae2-aa18-5f93ea2a0d6c|imgt:hasClinicalIndication|imgt:Psoriasis imgt:mAb_632|imgt:imgt_note| Novartis announced today a swap of clinical assets for equity with Mereo BioPharma Group Ltd. The deal involves compounds in areas of unmet medical need including BPS-804, to improve bone density in brittle bone syndrome, an orphan disease; BCT-197 for acute exacerbations in COPD, and BGS-649 for obese men with hypogonadotrophic hypogonadism to normalize testosterone levels. (July 29, 2015) Originally developed by Novartis, BPS-804 was acquired by Mereo BioPharma3 Limited in July 2015. imgt:Construct_878|rdf:type|imgt:Construct imgt:Clone_1046|imgt:isOriginCloneOf|imgt:mAb_1046 imgt:mAb_820|imgt:inn_proposed_list|118 (2017) imgt:IgG4-kappa_912|obo:RO_0002162|imgt:Homsap imgt:StudyProduct_f5b5f2b6-8fd7-38b9-938b-4f838a392b75|imgt:application_type|Therapeutic imgt:L-IOTA-1|imgt:describes|imgt:IG-Light-Iota-1-IGI1 imgt:FPIA_%5BPROTEIN_4REPEATS%5D2-3S-FC_733|rdf:type|imgt:MAbReceptor imgt:StudyProduct_be5358f9-3086-3522-8547-d074b5a04c80|rdf:type|obo:NCIT_C174271 imgt:CD4_(p55_T_cell_surface_antigen_T4/Leu-3)-Pseudomonas_aeruginosa_exotoxin_A|imgt:construction_detail|Fusion - CD4 (p55, T cell surface antigen T4/Leu-3) - Pseudomonas aeruginosa exotoxin A _:Bf01397a08755b2e5599f218c75e1236c|imgt:hasDesignation|imgt:Orphan_drug imgt:StudyProduct_d67b1219-df4f-3910-9c4c-c34f7efcf865|rdfs:label|StudyProduct_d67b1219-df4f-3910-9c4c-c34f7efcf865 _:Bd4eca48c0e85a45426d335e3efdf6404|imgt:hasDesignation|imgt:Orphan_drug imgt:StudyProduct_7cf9c789-4569-32e3-b570-6f6bd2343490|imgt:application_type|Therapeutic imgt:Product_550b04fe-bcb2-3cf8-ab43-92130dafa2b3|imgt:isProducedBy|imgt:AbbVie_Inc imgt:mAb_192|imgt:hasOriginClone|imgt:Clone_192 imgt:SCFV-KAPPA-HEAVY-SCFV-HEAVY-KAPPA|rdf:type|imgt:ChainLabels imgt:FPIA_%5BPROTEIN_VLIKE%5D2-1S-FC_247|http://semanticscience.org/resource/SIO_000291|imgt:CD86 imgt:StudyProduct_2443544f-9e51-33f7-be6e-0423708447df|imgt:hasClinicalIndication|imgt:Eosinophilic_gastroenteritis _:B941dd6899d388775006493d265b9b4d4|imgt:hasDesignation|imgt:Orphan_drug pubmed:21170091|dc:contributor|Karakantza M imgt:Construct_392|obo:BFO_0000051|imgt:Segment_392_2 imgt:mAb_305|imgt:inn_recommended_list|38 (1997) imgt:mAb_808|imgt:hasMabReceptor|imgt:IgG1-kappa_808 imgt:EGFR1|skos:definition|EGFR protein imgt:IgG4-kappa_1210|rdfs:label|IgG4-kappa_1210 imgt:Construct_138|imgt:isConstructOf|imgt:IgG1-kappa_MM_138 imgt:mAb_370|imgt:inn_proposed_list|104 (2010) imgt:mAb_422|imgt:hasProduct|imgt:Product_0d196a0b-ad4e-34ad-b360-537cee190370 imgt:IgG1-kappa_501|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:StudyProduct_50e9635b-a1da-3a13-bd40-082697af1c76|rdfs:label|StudyProduct_50e9635b-a1da-3a13-bd40-082697af1c76 imgt:Product_4a210fe1-cd13-31c5-a0f8-83e6e6417a4d|rdf:type|obo:NCIT_C51980 imgt:StudyProduct_e0523f80-1719-3f7e-a335-72cb39e65668|rdfs:label|StudyProduct_e0523f80-1719-3f7e-a335-72cb39e65668 imgt:11503|rdfs:label|11503 imgt:Celldex_Therapeutics_Inc|imgt:produces|imgt:Product_6fc221fc-63c6-300f-8844-5210f60014c6 imgt:Construct_258|obo:BFO_0000051|imgt:Segment_258_1 imgt:Product_2afcb1d2-59f0-3021-b52c-19a197ec5ec9|imgt:hasStudyProduct|imgt:StudyProduct_94109571-0d67-3d99-9eac-55b1be8e6370 imgt:StudyProduct_6df32054-85ca-320b-821e-1aaa146ca94c|imgt:development_technology| CrossMAb technology imgt:Age-related_macular_degeneration_(AMD)_neovascular_(wet)|imgt:isClinicalIndicationOf|imgt:StudyProduct_b7b4c1db-df22-3f75-96fc-bfdd0e484d13 imgt:IgG4-kappa_1287|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG4-kappa.png _:Bb8f3a2e470a0fc74a161df00dcda8d18|imgt:isDecisionOf|imgt:StudyProduct_f19a4730-ebae-3b17-9e9f-07ffc57c68a9 imgt:Segment_1246_1|obo:BFO_0000050|imgt:Construct_1246 _:Bc650f687496c77e4d9ee16c1de3903c8|imgt:hasStatut|imgt:approval imgt:IgG1-kappa_1154|rdfs:comment|IgG1 - kappa imgt:IgG1-lambda-PROTEIN_1296|imgt:fused_with| Homo sapiens IL21 (interleukin 21) Pr29-162, engineered (98.5%) (1:1) imgt:MedImmune|imgt:produces|imgt:Product_e9e52bcc-24ec-39dc-8de4-b4ba591c6845 imgt:StudyProduct_3413c33b-a4b2-365e-9fa5-d378577a0308|imgt:application_type|Therapeutic imgt:IgG1-kappa_MM_111|rdfs:comment|IgG1-kappa_MM obo:RO_0002162|rdf:type|owl:ObjectProperty imgt:Product_a5810bfd-fa83-3b91-b1a2-1fde9a86f7ba|imgt:hasStudyProduct|imgt:StudyProduct_005d9944-c515-3db3-943a-842810fe9642 imgt:mAb_488|imgt:hasProduct|imgt:Product_546d6daa-5d28-3e8b-9d12-ffa5d6ed0afa _:B429ef8e2dd5adb3b7ed73234fc2cd062|imgt:hasStatut|imgt:approval imgt:Construct_481|imgt:isConstructOf|imgt:Fab%27-G1-kappa-PEG-PEG_481 _:B1e0c4006d5016c9dc870f94c292dfc3d|imgt:isDecisionOf|imgt:StudyProduct_801c8339-57b5-3f8c-8836-5923647a48db imgt:IgG4-lambda_1031|imgt:hasMolecularComponent|imgt:IG imgt:IgG4-kappa_950|rdf:type|imgt:MAbReceptor imgt:mAb_91|rdf:type|obo:NCIT_C1909 imgt:Construct_424|rdf:type|imgt:Construct obo:NCIT_C29981|rdfs:subClassOf|obo:NCIT_C1909 imgt:mAb_651|imgt:hasMabReceptor|imgt:VH-VH%27-H-Gamma1-VL-VL%27-C-kappa_651 imgt:mAb_1014|imgt:inn_recommended_list|84 (2020) imgt:LEPR|rdfs:label|LEPR imgt:Cluster_of_Differentiation|skos:definition|Identifies proteins defined in the cluster of differentiation (CD) nomenclatures (originally defined as cluster of cell surface molecules identified by specific monoclonal antibodies). imgt:StudyProduct_88b7f4da-6add-3303-94de-de5618010eff|imgt:hasClinicalPhase|imgt:Phase_III imgt:hybrid|rdf:type|imgt:TaxonomyRelated_StructureType imgt:Construct_331|imgt:isConstructOf|imgt:FPIA_%5BPROTEIN%5D2-FC_331 imgt:Segment_374_1|rdf:type|imgt:Segment imgt:Product_9644c27e-d6e1-34ac-b2e2-7fc4cdf6bc66|imgt:isProducedBy|imgt:Vectura_Group_Plc imgt:Construct_763|obo:BFO_0000051|imgt:Segment_763_1 imgt:mAb_982|imgt:inn_recommended_list|83 (2020) obo:NCIT_C152710|rdfs:subClassOf|obo:NCIT_C1909 imgt:StudyProduct_c398d23a-1697-3b9d-be1d-6684184d1772|imgt:hasClinicalIndication|imgt:Heart_transplant_rejection imgt:IgG1-kappa_1276|rdfs:label|IgG1-kappa_1276 imgt:Product_b9a7e713-902d-3fb3-afff-5da968f3c336|imgt:hasStudyProduct|imgt:StudyProduct_8ddcfd94-ddb6-37ce-bd4f-fa0867c480ce imgt:Product_14914095-c8ee-3cb4-877f-013fc6ba8589|rdfs:label|Product_14914095-c8ee-3cb4-877f-013fc6ba8589 _:B1f9064a8a40f017c8da5b4e23906b3de|imgt:isDecisionOf|imgt:StudyProduct_132fafe7-9b8f-3d86-8705-46849fb24080 _:B865a69dfe442b873dbe55e79f1446904|dc:date|2021-12-07 _:B544527d36a081f0c809a27e091cba5c3|imgt:isDecidedBy|imgt:FDA imgt:ADC_Therapeutics|imgt:produces|imgt:Product_19a1534c-6a6d-3e36-8e22-4f68fcf59ddf imgt:bispecific|imgt:isTargetOf|imgt:(scFv-heavy-kappa)-(scFv-heavy-lambda)_498 imgt:Construct_491|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:G-ALPHA1-ALPHA2-LIKE|rdf:type|imgt:ChainLabels imgt:StudyProduct_319335a0-2bef-3d34-bb33-1ba138c412f9|imgt:isStudyProductOf|imgt:Product_39647f9c-5a2a-3d4d-b584-bce5721f1fed imgt:11304|rdfs:label|11304 imgt:StudyProduct_5aaf2721-67bc-315b-8810-084f9246df86|imgt:application_type|Therapeutic imgt:Product_35bd5711-24c5-3f61-b2db-ffaa28dc248f|imgt:hasStudyProduct|imgt:StudyProduct_6ee58395-ba07-36f4-abe7-f7b57669944c imgt:%5BIL1RAP_(interleukin-1_receptor_accessory_protein)-IL1R1_(type_1_interleukin-1_receptor_interleukin_1_receptor_type_I)%5D2-IGHG1_Fc_(Fragment_constant)|imgt:construction_detail|Fusion - [IL1RAP (interleukin-1 receptor accessory protein) - IL1R1 (type 1 interleukin-1 receptor, interleukin 1 receptor, type I)]2 - IGHG1 Fc (Fragment constant) imgt:StudyProduct_c6006853-c81f-353b-b151-1d6f639683af|imgt:isStudyProductOf|imgt:Product_95d79f23-a097-3b08-b973-202da2206ead imgt:StudyProduct_3114e87f-1cdb-3dbb-9326-bcde5d342889|imgt:hasClinicalIndication|imgt:Cancers_ovarian imgt:mAb_1299|rdfs:label|mAb_1299 imgt:Clone_569|rdfs:label|Clone_569 imgt:Segment_260_1|rdfs:label|Segment_260_1 imgt:Construct_830|imgt:isConstructOf|imgt:CPCA_PEPTIDE-PEG-FC_830 _:B5267f7d7363951a03c105a9662dbc449|imgt:isDecidedBy|imgt:EMA imgt:StudyProduct_d6eea420-21f8-33bb-9977-ccffea181200|rdfs:label|StudyProduct_d6eea420-21f8-33bb-9977-ccffea181200 imgt:mAb_1242|imgt:hasMabReceptor|imgt:IgG1-kappa_1242 imgt:mAb_1058|imgt:hasProduct|imgt:Product_0cd8ff0b-ebf8-3d6f-85de-2839ab7a8d46 imgt:Product_c792f957-68a0-3d5a-bf5b-bd0b528b5832|imgt:commun_name|XTEN-hGH _:B9f4dac0d8a020a96fca7f19fa3159c66|dc:date|2019-12-18 imgt:StudyProduct_3393d31f-18bd-3191-8d92-efbc7b554fa7|imgt:application_type|Therapeutic imgt:StudyProduct_a414af3e-eea8-303a-966b-5051ae5bf14b|imgt:hasDecision|_:B7b51b5e5ef21c296581307ef34240df5 imgt:IgG2-kappa_230|obo:RO_0002162|imgt:Hum imgt:StudyProduct_0f716783-e77d-3248-b12d-10abe68624c8|imgt:hasClinicalIndication|imgt:Septic_shock imgt:Construct_37|rdf:type|imgt:Construct imgt:mAb_940|imgt:inn_proposed_list|121 (2019) imgt:mAb_630|imgt:hasProduct|imgt:Product_9cc138f8-dc04-3bf1-a240-daa92d8d50e2 imgt:IgG2-kappa_469|rdf:type|imgt:MAbReceptor imgt:StudyProduct_bc0d9794-75bd-3a37-ab0d-df9bc7114583|imgt:isStudyProductOf|imgt:Product_c1583c88-e53a-3e51-9a2c-fabecf1e8960 imgt:Construct_278|obo:BFO_0000051|imgt:Segment_278_1 imgt:IG_Light_Kappa|rdfs:label|IG_Light_Kappa imgt:FUSION-SCFV(V-KAPPA-VH)-ETA|rdfs:label|FUSION-SCFV(V-KAPPA-VH)-ETA imgt:StudyProduct_64f62fb8-c9d6-33e3-a84a-a8a9713b02e3|imgt:hasClinicalIndication|imgt:Diabetic_macular_edema imgt:Product_571363e1-b863-3e4b-852a-36fb1cc4957c|imgt:comercial_name|EXTAVIA® pubmed:7695263|rdfs:label|PMID_7695263 pubmed:9265500|dc:contributor|Hines DK imgt:FPIA_FC-%5BPROTEIN%5D2_824|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/FPIA_FC-[PROTEIN]2.png imgt:L-V-D-J-C-SEQUENCE|imgt:imgt_link|http://www.imgt.org/IMGTScientificChart/SequenceDescription/displayimage.php?id=13 imgt:IL1RN|rdf:type|imgt:SegmentLabels imgt:StudyProduct_cb165dea-b32d-3a5d-9161-130862d4c9e9|imgt:isStudyProductOf|imgt:Product_c4ad3947-577f-31a6-9ca5-62124b9ab8cf imgt:StudyProduct_7bb4b624-6a3a-379b-b1e7-93902135949f|imgt:isStudyProductOf|imgt:Product_e29f95d1-36be-37c4-9018-e60cabbdb8fb imgt:PROTEIN_1DOMAIN-PEG_627|imgt:hasMolecularComponent|imgt:RPI imgt:mAb_712|imgt:imgt_note| There is one amino acid difference between the H chain of 10409 losatuxizumab (10342 losatuxizumab vedotin) CH2 S3 (238) and 10960 serclutamab (10959 serclutamab talirine) due to a site-specific drug attachment engineered cysteine CH2 C3 (238) in 10960 (conjugated in 10959).There are four amino acid differences (two in the VH and two linked to allotypes) between the H chain of of 10409 losatuxizumab (10342 losatuxizumab vedotin) VH R (31), S (100), CH3 E12 (355), M14 (357) and 10262 depatuxizumab (10263 depatuxizumab mafodotin) VH S (31), G (100), CH3 D12 (355), L14 (357).The amino acid sequence of the kappa chain (1-214 AA) is identical in 10262, 10263, 10342, 10409, 10959 and 10960. imgt:Product_37dbf624-575c-3ba0-b8f4-ad41ea714ebb|imgt:commun_name|ZW33 imgt:Segment_504_1|imgt:has_rank|1 imgt:Product_f4e496f3-7e6c-32b1-aa62-8491e0329ca3|imgt:comercial_name|LEMTRADA® imgt:Segment_750_1|rdf:type|imgt:Segment imgt:Segment_861_1|imgt:has_rank|1 imgt:StudyProduct_a17bc945-2871-36cb-aa6e-2fe64953f402|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_f9f91a5c-a710-3c19-8fea-34097d3b675b|rdfs:label|StudyProduct_f9f91a5c-a710-3c19-8fea-34097d3b675b imgt:mAb_481|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=481 imgt:Product_a444fd94-b0b7-35fd-bc5c-4dd8b912eed1|imgt:commun_name|PF-05335810 imgt:IgG4-kappa_44|rdf:type|imgt:MAbReceptor imgt:Construct_851|rdfs:label|Construct_851 imgt:StudyProduct_3b1174ed-1f4c-3e90-aebf-72ce60ef0cf1|imgt:hasClinicalIndication|imgt:Colitis imgt:StudyProduct_7d100d5a-05e0-3ffb-ad07-68ea0a7560bd|imgt:hasClinicalPhase|imgt:Phase_I/II imgt:IgG1-lambda_1022|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-lambda.png imgt:mAb_286|imgt:inn_name|technetium (99mtc) pintumomab imgt:Segment_642_1|imgt:hasImgtLabel|imgt:IgG4-kappa imgt:Construct_197|imgt:isConstructOf|imgt:IgG1-kappa_197 imgt:Clone_508|obo:RO_0002162|imgt:Musmus imgt:mAb_743|rdfs:label|mAb_743 imgt:StudyProduct_7a34b138-251b-35be-8436-2c6dc1728af2|imgt:isStudyProductOf|imgt:Product_25709140-bbc7-373c-9a44-2be9be3d8e9d imgt:mAb_180|imgt:hasImgtStructureEntry|imgt:8568 imgt:StudyProduct_7fbbee76-70ac-3b49-b030-8b7ad9569c07|rdfs:label|StudyProduct_7fbbee76-70ac-3b49-b030-8b7ad9569c07 imgt:IgG1-kappa_158|rdfs:label|IgG1-kappa_158 imgt:mAb_400|imgt:hasMabReceptor|imgt:IgG1-kappa_400 _:Be0b8df7ead9c0c8ca291927c2b901e40|imgt:isDecidedBy|imgt:FDA imgt:IgG1-kappa_47|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:Clone_481|rdf:type|obo:NCIT_C37925 imgt:PROTEIN_1DOMAIN_631|imgt:hasConstruct|imgt:Construct_631 imgt:Construct_895|imgt:hasImgtLabel|imgt:%5BTNFRSF13B_(tumor_necrosis_factor_receptor_(TNFR)_superfamily_member_13B_TACI_transmembrane_activator_and_CAML_Interactor)%5D2-IGHG1_Fc_(Fragment_constant) imgt:HSV|obo:RO_0002162|imgt:Humalp1 imgt:StudyProduct_394d4b82-fd16-3fbe-809d-af59b6380eb1|imgt:hasClinicalPhase|imgt:Phase_M imgt:StudyProduct_8a9cd26d-f333-3b71-8411-80fdfab1538b|imgt:isStudyProductOf|imgt:Product_031662a0-3a4d-355b-86b2-68009454e886 imgt:StudyProduct_e6cc2358-6c8b-34b7-a981-0870ff7fe000|imgt:isStudyProductOf|imgt:Product_a461e569-39a0-3c1c-8ef1-e32c2837aaa7 imgt:Product_161faa12-b0ac-3430-b158-48f495203162|imgt:isProducedBy|imgt:University_of_Aberdeen imgt:IL6|imgt:isTargetOf|imgt:IgG1-kappa_384 imgt:Product_406390c3-6cd8-3629-be68-66016fce19cf|imgt:hasStudyProduct|imgt:StudyProduct_9a1ace4b-c686-3cab-bf14-c4bc22f32a84 imgt:Construct_743|imgt:hasImgtLabel|imgt:IgG1-nd imgt:CPCA_PROTEIN-FC_819|obo:RO_0002162|imgt:Homsap imgt:StudyProduct_bb3319d9-9bf0-3ca2-8bea-3859c50d58bf|imgt:application_type|Therapeutic imgt:StudyProduct_74b41bf4-dd7e-3c1e-b02d-5c9335d22ece|rdfs:label|StudyProduct_74b41bf4-dd7e-3c1e-b02d-5c9335d22ece imgt:mAb_132|imgt:hasImgtStructureEntry|imgt:1SY6 imgt:Carcinoma_nasopharyngeal_(NC)|imgt:clinical_domain|Oncology imgt:MedImmune|imgt:produces|imgt:Product_8bdb3425-f72a-3777-be41-82fdaed26099 imgt:Product_bd756867-c2d7-332c-8078-ce332c14176d|imgt:hasStudyProduct|imgt:StudyProduct_01c02561-34f0-3864-a55d-2a07cc089cc1 imgt:Product_c7cf4dec-df13-33c9-9a7e-798c0993539c|imgt:commun_name|interferon alfa(-2b) imgt:mAb_1154|imgt:hasMabReceptor|imgt:IgG1-kappa_1154 imgt:Construct_778|rdf:type|imgt:Construct imgt:StudyProduct_f8928c21-029a-311e-a5ae-b2505b18b929|imgt:application_type|Therapeutic imgt:Clone_37|imgt:isOriginCloneOf|imgt:mAb_37 imgt:IgG1-kappa_321|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:mAb_969|imgt:hasImgtStructureEntry|imgt:11161 imgt:Product_d7375334-d0db-32f3-81ba-3cfa540a5cf4|imgt:hasStudyProduct|imgt:StudyProduct_bfa4c5bc-f925-34a6-aca5-541ba43c3b76 imgt:Novartis_Pharmaceuticals_Corp|imgt:produces|imgt:Product_e40335c6-1d9d-3d4d-b9fe-75c1775c1450 imgt:4CNI|rdf:type|obo:NCIT_C25402 imgt:SLAMF7|rdf:type|obo:NCIT_C25702 pubmed:7858182|dc:contributor|Bodmer MW imgt:Construct_512|rdf:type|imgt:Construct imgt:Segment_445_1|rdf:type|imgt:Segment imgt:Cancers_breast|imgt:isClinicalIndicationOf|imgt:StudyProduct_a30aa114-76b9-3dfd-aeb4-317ad0368396 imgt:Construct_225|rdf:type|imgt:Construct imgt:Product_261d61fb-02a3-3c36-8a44-8027b7a60a03|rdf:type|obo:NCIT_C51980 _:Be2dfaa81a5d78061fd4de59518c18a97|imgt:isDecisionOf|imgt:StudyProduct_1204991a-cd46-3f61-85bb-d54a4922eb42 imgt:StudyProduct_c4f75093-f1f4-3917-bb28-01d27e6d0db6|imgt:hasClinicalIndication|imgt:CD70-positive_hematologic_malignancies imgt:LRRNT|rdfs:label|LRRNT imgt:Construct_898|imgt:hasImgtLabel|imgt:IgG4-kappa imgt:StudyProduct_3bee2b98-2cf0-3b1b-a82e-3fc7bbac25d6|imgt:hasClinicalPhase|imgt:Phase_II imgt:IgG1-kappa_MM_282|imgt:hasMolecularComponent|imgt:IG imgt:mAb_1214|imgt:hasImgtStructureEntry|imgt:11966 imgt:mAb_879|imgt:inn_name|pivekimab sunirine imgt:Segment_118_1|imgt:has_rank|1 imgt:Psoriasis_pediatric|imgt:isClinicalIndicationOf|imgt:StudyProduct_1ab8d4c3-d225-3383-97de-5f1bb986f6f1 https://doi.org/10.1080/2162402X.2018.1532759|dc:contributor|Weissensteiner T imgt:IgG2-lambda_664|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG2-lambda.png imgt:StudyProduct_1200f9cf-8825-34f4-abe8-7b78c6049249|imgt:hasExpressionSystem|imgt:_CHO_DG44_(Chinese_Hamster_Ovary)_cells imgt:V-GAMMA|rdf:type|imgt:V-DomainLabel imgt:StudyProduct_7db4409b-932c-3b0e-98bc-041e914b8692|imgt:isStudyProductOf|imgt:Product_643b4245-4368-3cc6-9e2e-c746cf6d7ea5 https://doi.org/10.1016/0161-5890(94)00146-R|dc:date|1995 imgt:IgG4-kappa_846|imgt:isMabReceptorOf|imgt:mAb_846 imgt:Solid_tumors_advanced_or_metastatic|imgt:isClinicalIndicationOf|imgt:StudyProduct_175feb57-cfac-34ae-9b82-f9d393da7ca5 imgt:Product_6700b7b7-e2af-3ee8-873f-cb4f2bdca604|imgt:hasStudyProduct|imgt:StudyProduct_f41ae699-17c8-38d8-a153-5c12ec20f37a imgt:Construct_1147|rdf:type|imgt:Construct imgt:Product_c311e57b-5fdf-3259-ae3a-0eab5583a035|imgt:commun_name|MDX-447 obo:NCIT_C95755|rdfs:subClassOf|obo:NCIT_C1909 imgt:mAb_286|imgt:inn_proposed_list|75 (1996) _:B4207407f9437d3ad5b97f374d30e8d05|dc:date|2017-09-20 imgt:Clone_58|imgt:isOriginCloneOf|imgt:mAb_58 imgt:StudyProduct_aedffa5f-0866-31f3-b361-3e84aef3d109|imgt:application_type|Therapeutic imgt:mAb_294|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=294 imgt:IgG1-kappa_1151|imgt:isMabReceptorOf|imgt:mAb_1151 imgt:Cancers_colorectal_microsatellite_stable_metastatic|imgt:clinical_domain|Oncology imgt:Product_cd3bec45-390a-31ab-b8e2-3ad6f87b4c5e|rdfs:label|Product_cd3bec45-390a-31ab-b8e2-3ad6f87b4c5e imgt:PROTEIN_1DOMAIN_631|imgt:isMabReceptorOf|imgt:mAb_631 imgt:StudyProduct_db2405b4-3c00-39c2-a8e3-2ad1c51f9e46|rdf:type|obo:NCIT_C174271 _:B5c81c21c7da3d82c1b5e8de7c76160e1|imgt:hasDesignation|imgt:Orphan_drug imgt:StudyProduct_0bcfa7a5-b05a-3c0d-b5f4-a2c98ae2a8da|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_06e79333-0df6-3903-975e-83ef7a568ef7|imgt:isStudyProductOf|imgt:Product_ed8d0555-7f62-3cdb-9892-679238204c82 imgt:StudyProduct_38906f87-bda5-34ff-be13-2ad09d9a87b9|imgt:hasClinicalPhase|imgt:Phase_M imgt:IgG1-lambda_1022|rdfs:label|IgG1-lambda_1022 imgt:Construct_583|rdfs:label|Construct_583 imgt:StudyProduct_ef029a7b-df7c-3925-84a0-031d671632a1|rdf:type|obo:NCIT_C174271 imgt:Inflammatory_diseases|imgt:clinical_domain|Immunology imgt:StudyProduct_5238c8b8-e8b4-32d3-a68f-157633d0b23b|rdfs:label|StudyProduct_5238c8b8-e8b4-32d3-a68f-157633d0b23b imgt:Product_788b3959-d5c8-36a5-9cf6-738181181b51|imgt:commun_name|TGTX-1101 imgt:Product_a142a049-54e9-384c-a505-7346d9abf873|rdfs:label|Product_a142a049-54e9-384c-a505-7346d9abf873 imgt:Clone_1215|imgt:clone_name|2276-T2-04 imgt:XTEN|rdf:type|imgt:SegmentLabels imgt:Congenital_hyperinsulinism_(CHI)|imgt:isClinicalIndicationOf|imgt:StudyProduct_051d8124-b535-3374-8060-ad17a4f6caec imgt:Product_8dd9c7a0-e2a1-3cf3-8a77-90dc8f8a4372|imgt:commun_name|1F5 imgt:_CHO-K1|imgt:isExpressionSystemOf|imgt:StudyProduct_ba74e17d-054e-3ed5-8dbc-8dbe4ef00021 imgt:StudyProduct_be359762-d4a5-3e56-b121-4315410d69db|imgt:hasClinicalIndication|imgt:Esophagitis_eosinophilic pubmed:20848453|rdfs:label|PMID_20848453 imgt:mAb_221|imgt:imgt_note| Bispecific molecules directed to tumor associated glycoprotein-72 and Fc receptor. WO 1999019362 A1 , Deo YM and Keler T (1999) As of August 2009, Medarex, Inc. operates as a subsidisary of Brystol-Myers Squibb company. The two Fab’ are chemically linked as described in Russoniello C (1992) Clinical Cancer Res. 4:2237-2243 (1998) PMID: 9748144 (directed chemical coupling of the Fab’-thionitrobenzoate derivative (Fab’-TNB) of H22 with the Fab’-SH of HCC49). H22 F(ab') binds CD64 (FcγRI) (but outside the normal ligand binding site for IgG) and HCC49 F(ab') binds TAG-72. MDX-220 directs CD64-positive effector cells (monocytes, macrophages…) to tumor cells that overexpress TAG-72, to phagocyte or kill them. imgt:Clone_158|rdf:type|obo:NCIT_C37925 imgt:Segment_1298_1|imgt:hasImgtLabel|imgt:ACE2 _:Bd7c02b105e7f1b4ef4d04dee640a7f61|imgt:isDecidedBy|imgt:FDA imgt:Construct_827|obo:BFO_0000051|imgt:Segment_827_1 imgt:StudyProduct_deb0d4c3-e3f4-3460-89c0-e57d8a8012bf|rdf:type|obo:NCIT_C174271 imgt:Construct_1056|obo:BFO_0000051|imgt:Segment_1056_1 imgt:IgG3-nd|imgt:construction_detail|IgG3 - nd imgt:MH1-Alpha-MH1-A|imgt:hasChainTypeLevel|imgt:MH1-Alpha imgt:NovImmmune|imgt:produces|imgt:Product_32616388-2f3b-3bc7-9429-693216dd67ab imgt:StudyProduct_ba051135-cbbf-3584-9f69-8c5f8a7bcd62|rdfs:label|StudyProduct_ba051135-cbbf-3584-9f69-8c5f8a7bcd62 imgt:Product_e0278568-febe-37ab-bbd2-9027ac7db7e5|imgt:hasStudyProduct|imgt:StudyProduct_0b2cb239-be87-31e9-839a-31757af1e6c3 imgt:Kidney_transplantation_prevention_of_delayed_graft_function_(DGF)|rdfs:label|Kidney_transplantation_prevention_of_delayed_graft_function_(DGF) imgt:IgG1-kappa_87|imgt:hasMolecularComponent|imgt:IG imgt:StudyProduct_5ad71dc8-9728-3c41-aef5-1290aea0238f|imgt:isStudyProductOf|imgt:Product_30cfee56-6804-3214-89a1-b3e5246abb80 imgt:Fab-nd-nd_320|rdfs:comment|Fab - nd - nd _:Badcbba74a42bb88cc9338119103b5a7c|dc:date|2015-10-23 imgt:mAb_513|imgt:hasMabReceptor|imgt:MAbReceptor_513 imgt:mAb_1175|imgt:inn_proposed_list|125 (2021) imgt:StudyProduct_a32d582b-55bb-35e7-9274-4cdbe7710561|imgt:hasDecision|_:B1c27eff33108724b257e02e5cd054d6d imgt:mAb_69|rdfs:label|mAb_69 imgt:Segment_1148_1|imgt:has_rank|1 imgt:mAb_528|imgt:hasImgtStructureEntry|imgt:10010 imgt:Product_fa00974f-cc39-3d66-81f4-d1d02461414c|imgt:isProducedBy|imgt:Roche_F_Hoffmann-La_Roche_Ltd imgt:StudyProduct_30a720ac-7d77-31fb-963e-7075ddafc936|imgt:application_type|Therapeutic imgt:mAb_772|imgt:hasImgtStructureEntry|imgt:10467 imgt:mAb_937|imgt:inn_name|amivantamab imgt:IgG1-lambda_588|rdf:type|imgt:MAbReceptor imgt:StudyProduct_3b191dcf-99b4-3707-b950-63b947220000|imgt:application_type|Therapeutic imgt:StudyProduct_15a0a4ce-6b3c-34bc-9df1-8eb1c35bc123|rdfs:label|StudyProduct_15a0a4ce-6b3c-34bc-9df1-8eb1c35bc123 imgt:mAb_486|imgt:hasOriginClone|imgt:Clone_486 _:B1f894a17c2d729d8c73a10da58b43dc4|imgt:isDecisionOf|imgt:StudyProduct_58fd01ed-11b1-3d24-b0db-8844bb814951 imgt:Construct_637|imgt:hasImgtLabel|imgt:IFNB1_(interferon_beta_1_IFNB)_*a_(C38)_22-187 imgt:StudyProduct_87df2003-d770-3cc3-88b8-b055ef490e3c|rdfs:label|StudyProduct_87df2003-d770-3cc3-88b8-b055ef490e3c imgt:Product_1a5a7655-b7fd-3b5a-8928-0839477de93d|imgt:isProducedBy|imgt:MorphoSys imgt:Segment_751_1|rdfs:label|Segment_751_1 imgt:OSMR|obo:RO_0002162|imgt:Homsap imgt:StudyProduct_2312fb48-bad1-35ad-8365-5f0d8342d5de|rdfs:label|StudyProduct_2312fb48-bad1-35ad-8365-5f0d8342d5de imgt:Product_20a3f071-ad32-3ce5-bf2d-1658fb45f799|rdfs:label|Product_20a3f071-ad32-3ce5-bf2d-1658fb45f799 imgt:mAb_560|imgt:hasOriginClone|imgt:Clone_560 imgt:Product_35151183-9d05-3e40-99a6-c6765fb8df78|imgt:commun_name|PR-1625011 imgt:mAb_849|imgt:hasMabReceptor|imgt:IgG4-kappa_849 imgt:Product_b12ab81c-147d-34f3-aa01-f95e94eb88de|imgt:commun_name|CaCP-29 imgt:Segment_776_1|rdf:type|imgt:Segment imgt:mAb_950|imgt:inn_proposed_list|121 (2019) imgt:Product_aba2626b-9c25-3e94-b338-0474747ed52b|rdfs:label|Product_aba2626b-9c25-3e94-b338-0474747ed52b imgt:Construct_936|obo:BFO_0000051|imgt:Segment_936_1 imgt:StudyProduct_c6105a47-0fa2-36f2-aeb1-db5d7d615bc2|rdfs:label|StudyProduct_c6105a47-0fa2-36f2-aeb1-db5d7d615bc2 imgt:mAb_478|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=478 imgt:IgG1-nd_43|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-nd.png imgt:FGFR1|obo:RO_0002162|imgt:Homsap imgt:Segment_369_1|imgt:hasImgtLabel|imgt:IgG2-kappa imgt:Product_38dcb3a9-d366-365a-80b8-285719fdf525|rdf:type|obo:NCIT_C51980 imgt:Product_e45601ef-1642-347e-acf6-1d5dc5b29091|rdfs:label|Product_e45601ef-1642-347e-acf6-1d5dc5b29091 imgt:Clone_633|imgt:clone_name|BC8 imgt:mAb_952|imgt:hasImgtStructureEntry|imgt:11145 imgt:Colitis_ulcerative_(UC)|imgt:isClinicalIndicationOf|imgt:StudyProduct_a48ff6b5-27dc-38b4-b171-f6bc8fba6a2d imgt:Product_c2414a6e-ad35-3580-8d4a-413aebd6d777|imgt:commun_name|MOR101 imgt:StudyProduct_683283a5-8ee3-3684-8cd5-82144f28dbc5|rdf:type|obo:NCIT_C174271 imgt:Segment_1075_1|imgt:hasImgtLabel|imgt:half-IG_G1-kappa/(scFv-kappa-heavy)-h-CH2-CH3 imgt:Interstitial_cystitis|imgt:isClinicalIndicationOf|imgt:StudyProduct_f03529af-62ae-377e-9f3a-4dae8ef40574 obo:NCIT_C174638|rdfs:subClassOf|obo:NCIT_C1909 _:B86df446dd0e8eff0694f247ce4f9e3a0|imgt:isDecisionOf|imgt:StudyProduct_2e13c6a2-af13-34bc-8e4c-5702a14274ce imgt:StudyProduct_f194b2c1-54af-36a1-9743-5293ec4e34ae|rdfs:label|StudyProduct_f194b2c1-54af-36a1-9743-5293ec4e34ae imgt:StudyProduct_d5546bb8-654e-3baa-9401-775ab79759eb|rdfs:label|StudyProduct_d5546bb8-654e-3baa-9401-775ab79759eb imgt:StudyProduct_eecf5ce4-fbe7-3768-b545-33e1eb7be4a0|imgt:application_type|Therapeutic imgt:StudyProduct_b817e0d6-e270-368b-9f21-b99d0f4e7e9c|imgt:isStudyProductOf|imgt:Product_442a60e9-44f1-3d58-be60-70178de04384 imgt:StudyProduct_bd3a5690-76d8-3798-bc05-a5cc72b447c9|imgt:application_type|Therapeutic imgt:IgG1-kappa_1185|imgt:isMabReceptorOf|imgt:mAb_1185 imgt:Segment_1006_1|obo:BFO_0000050|imgt:Construct_1006 _:Bae0be993847c5363b95c6cf4316e7ca1|imgt:hasStatut|imgt:approval imgt:scFv-TR_798|http://semanticscience.org/resource/SIO_000291|imgt:bispecific imgt:StudyProduct_40fc9c18-8047-3b09-810d-4e0bc08fe647|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_3f9bd427-1ccd-3281-9c05-1b70fead3c8d|imgt:hasClinicalPhase|imgt:Phase_M imgt:StudyProduct_cdf565e1-ead4-3a2d-97be-b89ca1f90952|imgt:development_technology| TRuC-T Cell Therapy imgt:FUSION-%5BTNFRSF13C%5D2-FC-GAMMA-1|rdfs:label|FUSION-[TNFRSF13C]2-FC-GAMMA-1 imgt:Product_4391f6b4-98b1-38e2-94d2-967326f820fe|imgt:hasStudyProduct|imgt:StudyProduct_bb657515-54e5-392c-a891-61c8e3ea325b imgt:IgG1-kappa_354|rdfs:label|IgG1-kappa_354 imgt:StudyProduct_56707d84-4db0-39aa-b4f3-46813eb2b013|imgt:development_technology| Abgenix's XenoMouse® imgt:Construct_563|imgt:hasImgtLabel|imgt:IgG4-kappa imgt:StudyProduct_fc6b0f53-0956-3020-8280-75e1126908e4|imgt:hasClinicalIndication|imgt:Cancers_small_cell_lung_(SCLC) imgt:mAb_96|rdfs:label|mAb_96 imgt:Systemic_sclerosis|imgt:isClinicalIndicationOf|imgt:StudyProduct_292db794-322f-322e-8b76-7185b7823008 imgt:StudyProduct_c6ccc3ad-b770-3749-bc17-36286460a4bd|rdf:type|obo:NCIT_C174271 imgt:Product_01c40390-bb74-3de1-b375-a335e45892b8|imgt:commun_name|VGX-300 imgt:(VH-CH2-CH3)2_S_1220|obo:RO_0002162|imgt:Chi imgt:StudyProduct_3dd848dc-265a-30d8-ba58-470497ee2ecb|imgt:hasClinicalIndication|imgt:Acute_lymphocytic_leukemia_(ALL) imgt:StudyProduct_b90a5902-ae88-3923-ad6c-cff986b5b910|imgt:hasClinicalIndication|imgt:Crohn's_disease_(CD) imgt:THB_conjugated_1115|obo:RO_0002162|imgt:syncon imgt:Nventa_Biopharmaceuticals_Corporation|rdfs:label|Nventa Biopharmaceuticals Corporation imgt:D-gene|dc:identifier|imgt_000014 imgt:scFv-kappa-heavy-IGHG4_h_(CO)-CD28_(TM)-TNFRSF9_(CY)_CD247-TEApep-EGFRt_1099|http://semanticscience.org/resource/SIO_000291|imgt:CD19 imgt:G-BETA|skos:definition|G-DOMAIN first domain [D1] of a MH2-Beta chain, encoded by EX2 of a MH2 beta gene imgt:Construct_153|imgt:isConstructOf|imgt:Fab-nd-nd_153 imgt:Product_4a5c4039-6661-3fa4-a1ee-9a7e6ff795b2|imgt:hasStudyProduct|imgt:StudyProduct_c0c3e436-3c22-3968-a5d0-efc387b4d777 imgt:Construct_832|imgt:isConstructOf|imgt:IgG1-kappa_832 imgt:mAb_629|rdf:type|imgt:INN imgt:Extranodal_NK/T-cell_lymphoma_(ENKTL)|rdfs:label|Extranodal_NK/T-cell_lymphoma_(ENKTL) imgt:VH-H-GAMMA-1|rdfs:label|VH-H-GAMMA-1 imgt:Carcinoma_head_and_neck_squamous_cell_carcinoma_(HNSCC)|imgt:clinical_domain|Oncology imgt:StudyProduct_5eba0bdd-228a-37c4-8fce-1867c33b991d|imgt:hasClinicalPhase|imgt:Phase_M imgt:IgG1-kappa_1280|imgt:isMabReceptorOf|imgt:mAb_1280 imgt:IgG4-kappa_781|rdfs:comment|IgG4 - kappa imgt:mAb_171|imgt:hasMabReceptor|imgt:IgG4-lambda_171 imgt:StudyProduct_df2cfb74-301d-31c5-871c-e021350b02af|imgt:application_type|Therapeutic imgt:Canlupfam_MS4A1|rdf:type|obo:NCIT_C25702 imgt:mAb_907|rdfs:label|mAb_907 imgt:StudyProduct_30ba83bf-e275-3f08-bf5c-e896c99662ee|imgt:hasDecision|_:B11f0ffeaffec4467088bb0abf66de36a _:B7dfb5ce205d033ff3d7f45aa8ecdc482|rdf:type|obo:NCIT_C53285 imgt:StudyProduct_0bf6eb3e-ae1f-3211-b64b-2e4f87af2cee|imgt:hasClinicalIndication|imgt:Nasal_polyposis imgt:Product_cbd0baaf-87ab-3efd-87a0-619e0f9667a5|imgt:hasStudyProduct|imgt:StudyProduct_9fb4386e-5e4a-3b51-904f-1105838ad11e pubmed:7719381|dc:contributor|Xiang J. imgt:APP|imgt:isTargetOf|imgt:IgG4-kappa_378 _:Bfd334cdbbd98d6c2ef3df0a27e18f83c|imgt:isDecidedBy|imgt:FDA imgt:StudyProduct_e9a7c8f3-f7cf-359e-b817-11dba4592ec9|imgt:hasClinicalPhase|imgt:Phase_I imgt:Segment_825_1|rdf:type|imgt:Segment imgt:Construct_151|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Product_0872db0d-9d18-336b-aa58-45b3210cb065|imgt:isProducedBy|imgt:Memorial_Sloan-Kettering_Cancer_Center _:Ba5a9acf928dfc91ed06177aec20e1be3|imgt:hasStatut|imgt:approval imgt:Product_90b985a1-c752-3673-801f-841c91bb6278|imgt:isProductOf|imgt:mAb_714 _:Bfaad2e7c1461d7a240c704c9bb4ee582|rdf:type|obo:NCIT_C53285 imgt:StudyProduct_98dc1b90-812d-3b2c-a33d-4c5121b2f350|imgt:hasDecision|_:B2ce12e99eb7ae1cc6af52e9fd11aed03 obo:NCIT_C71542|rdf:type|owl:Class imgt:IgG1-kappa-4F_1266|imgt:hasMolecularComponent|imgt:IG imgt:CPCA_three-helical_bundle_1046|http://semanticscience.org/resource/SIO_000291|imgt:bispecific imgt:Fab-G4-nd|rdfs:label|Fab - G4 - nd imgt:IL18|obo:RO_0002162|imgt:Homsap imgt:mAb_167|rdf:type|obo:NCIT_C1909 imgt:TNFRSF13C|rdf:type|imgt:SegmentLabels imgt:mAb_669|imgt:imgt_note| XOMA 358 is a fully human negative allosteric modulating insulin receptor antibody (which attenuates insulin action) derived from the XMet platform. It is being investigated as a novel treatment for non-drug-induced, endogenous hyperinsulinemic hypoglycemia (low blood glucose caused by excessive insulin production), as well as hypoglycemia after bariatric surgery and other related disorders. imgt:Product_d30bc7a3-4607-3c49-9f28-691cff219e66|imgt:commun_name|CR6261 imgt:IgG1-lambda_266|rdf:type|imgt:MAbReceptor imgt:mAb_893|imgt:hasMabReceptor|imgt:PROTEIN_1DOMAIN_893 imgt:StudyProduct_6586edfa-dd5f-32c0-bbb9-6c7d64dc0480|imgt:hasClinicalIndication|imgt:Psoriasis imgt:StudyProduct_961a8cbb-97f6-330d-a900-59d58ea33047|imgt:application_type|Therapeutic imgt:IgG1-kappa_654|imgt:hasConstruct|imgt:Construct_654 imgt:Autoimmunity|rdf:type|obo:NCIT_C185637 imgt:Product_71907de7-5031-39df-916b-6180a1642a1c|imgt:commun_name|PF-00547659 imgt:StudyProduct_b44fe2d8-f4da-3c16-a5f7-2d62a5c7deb7|imgt:hasClinicalIndication|imgt:Cytomegalovirus_(CMV)_retinitis_in_HIV_individuals imgt:mAb_634|imgt:inn_number|9306 imgt:CH1-IGHG1|skos:definition|CH1 corresponding to constant region of immunoglobulin heavy chains imgt:FUSION-TNFRSF1A-GAMMA-1|skos:definition|TNFRSF1A fused with G1 H-CH2-CH3 imgt:mAb_264|imgt:hasImgtStructureEntry|imgt:8412 imgt:Product_5599efd0-7eee-32e0-ad93-253e80b8b7e3|imgt:commun_name|romosozumab-aqqg imgt:Cancers_prostate|rdfs:label|Cancers_prostate imgt:Segment_776_1|imgt:has_rank|1 imgt:StudyProduct_4d1292cd-3039-3fa6-b39f-3bfb654a58a7|rdf:type|obo:NCIT_C174271 imgt:Segment_566_1|obo:BFO_0000050|imgt:Construct_566 imgt:PharmAbcine_Inc|rdfs:label|PharmAbcine Inc imgt:StudyProduct_9282dfd1-9bea-3b0f-8a57-206f14824065|imgt:isStudyProductOf|imgt:Product_645dae0f-4159-327b-abf7-586dd4526f26 imgt:Clone_1143|rdf:type|obo:NCIT_C37925 imgt:Product_e8799a18-910d-3034-89ea-23f84f7fa73f|imgt:isProducedBy|imgt:Novartis_Pharmaceuticals_Corp imgt:Construct_1291|obo:BFO_0000051|imgt:Segment_1291_1 imgt:mAb_1040|imgt:inn_name|zuberitamab imgt:LRR15|rdfs:label|LRR15 imgt:StudyProduct_ef73ae15-7bea-36d6-947c-43594144d0a8|imgt:hasClinicalIndication|imgt:Melanoma imgt:Product_ffe79d3a-7340-3c62-883c-916bc4a8044e|imgt:hasStudyProduct|imgt:StudyProduct_4a815db4-c662-3d9e-a584-51db01c7a9fa imgt:Product_4a19313c-79ad-3816-90a3-6d5c4ee71379|rdf:type|obo:NCIT_C51980 imgt:mAb_571|imgt:inn_number|10148 imgt:Product_e69abcdb-3e37-3bed-a630-2ae4ee615e7a|imgt:isProducedBy|imgt:Abgenix imgt:Product_6900c4b8-952b-3ae4-8daf-ac079d21e5eb|imgt:isProducedBy|imgt:Boston_Pharmaceuticals imgt:Segment_11_1|imgt:has_rank|1 imgt:StudyProduct_c324869b-0dfa-314c-bbda-8940375ac705|imgt:application_type|Therapeutic imgt:mAb_1107|imgt:imgt_note| WHO Drug Information, Vol. 34, No. 3, 2020. Proposed INN List 124 – COVID-19 (special edition) (9 October 2020) pages 642-669. Proposed INN List 124 (19 December 2020, published on 22 January 2021) pages 929-1102. On February 9, 2021, Food and Drug Administration (FDA) issued an Emergency Use Authorization (EUA) for emergency use of bamlanivimab and etesevimab to be administered together for the treatment of mild to moderate coronavirus disease 2019 (COVID-19) in adults and pediatric patients. Press release Bamlanivimab and etesevimab are neutralizing IgG1 monoclonal antibodies that bind to distinct but overlapping epitopes within the receptor binding domain of the spike protein of SARS-CoV-2. They are both investigational drugs and are not currently approved for any indication. On February 25, 2021, FDA reissued the February 9, 2021 letter. imgt:Gas_gangrene|imgt:isClinicalIndicationOf|imgt:StudyProduct_38402fd4-efab-3d3d-bf21-6f1360722674 imgt:mAb_1168|imgt:hasImgtStructureEntry|imgt:11625 imgt:TR-GAMMA-4|rdf:type|imgt:ChainLabels imgt:IG-Heavy-Xi|rdf:type|imgt:ClassLevelChainType imgt:StudyProduct_baa41ac1-2853-3eba-ae43-e487b5c0b4c0|rdfs:label|StudyProduct_baa41ac1-2853-3eba-ae43-e487b5c0b4c0 imgt:mAb_1270|imgt:hasProduct|imgt:Product_98a40d96-4f45-305e-ab3e-b032a15f3eef imgt:Lambda-Lambda|imgt:isDefinedBy|imgt:Lambda-Lambda imgt:ENZ-XTEN_702|imgt:hasConstruct|imgt:Construct_702 imgt:10788|imgt:isImgtStructureEntryOf|imgt:mAb_886 imgt:scFv-heavy-kappa-CD8A_(CO-TM)-TNFRSF9_(CY)-CD247_1103|rdf:type|imgt:MAbReceptor imgt:Clone_1028|imgt:isOriginCloneOf|imgt:mAb_1028 imgt:Segment_94_1|obo:BFO_0000050|imgt:Construct_94 imgt:StudyProduct_bf5eb408-cd4f-368d-9967-1230c1d1e925|imgt:hasClinicalIndication|imgt:Solid_tumors imgt:GlaxoSmithKline|imgt:produces|imgt:Product_6082be18-1302-36ab-8a6c-75b884b65d62 imgt:Product_689cd79f-29d1-3d43-bdd9-edb405308805|imgt:hasStudyProduct|imgt:StudyProduct_8520474f-a705-3f52-b54e-4a6a92032f13 imgt:Segment_1162_1|imgt:has_rank|1 imgt:IgG1-kappa_760|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:Clone_171|imgt:isOriginCloneOf|imgt:mAb_171 obo:NCIT_C157242|rdfs:subClassOf|obo:NCIT_C1909 imgt:FCGR3B|rdf:type|imgt:ChainLabels imgt:Segment_154_1|obo:BFO_0000050|imgt:Construct_154 imgt:IgG1-kappa-4cys-drug_1274|imgt:hasConstruct|imgt:Construct_1274 imgt:Construct_662|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:IgG2-lambda_470|obo:RO_0002162|imgt:Homsap imgt:mAb_1026|rdf:type|imgt:INN imgt:IgG1-kappa_MM_269|rdfs:label|IgG1-kappa_MM_269 imgt:mAb_720|imgt:inn_number|10498 imgt:GCG_(Pr146-178)|rdfs:label|GCG (Pr146-178) imgt:IgM-nd|imgt:construction_detail|IgM - nd imgt:Construct_131|imgt:hasImgtLabel|imgt:Fab%27-G1-kappa imgt:CPCA_PROTEIN-PEG-FC_613|rdf:type|imgt:MAbReceptor obo:NCIT_C142821|rdf:type|owl:Class _:Bf5497b162f109b6b3e707dedc13351ae|rdf:type|obo:NCIT_C53285 imgt:StudyProduct_a4a7bca6-26d4-3a2d-b63d-927b4e781968|imgt:development_technology| Medarex’s UltiMAb® imgt:Clone_1243|rdf:type|obo:NCIT_C37925 imgt:IgG4-kappa_385|imgt:isMabReceptorOf|imgt:mAb_385 _:Bd4c073dc1dfdcf018d16c24cfbac9ffe|imgt:hasDesignation|imgt:Orphan_drug imgt:StudyProduct_7d267f09-5c2d-385e-9f8e-59d3f4aafe63|rdf:type|obo:NCIT_C174271 imgt:Product_1ef9686e-7d67-35c1-af7f-537b5eb7aee2|imgt:commun_name|c13C6-FR1-N imgt:Segment_27_1|imgt:hasImgtLabel|imgt:IgG3-nd imgt:11094|rdf:type|obo:NCIT_C25402 imgt:IgG4-kappa_548|rdfs:comment|IgG4 - kappa imgt:Product_bf813acf-a5a5-3c97-95c6-5809bda944e1|rdf:type|obo:NCIT_C51980 imgt:mAb_917|rdfs:label|mAb_917 imgt:Product_485d748c-9ee2-352a-aaf4-3297a649c274|imgt:isProductOf|imgt:mAb_334 imgt:_CHOK1SV_(expresses_glutamine_synthetase_(GS)_endogenously)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_0a8a5bf8-b179-3f11-aca7-644878e57936 imgt:mAb_152|imgt:inn_number|7615 imgt:StudyProduct_d9feeca2-18ef-3224-a694-0b590cc924db|rdfs:label|StudyProduct_d9feeca2-18ef-3224-a694-0b590cc924db imgt:StudyProduct_80df9e94-ee60-3921-a952-9cd7b81e01e6|imgt:isStudyProductOf|imgt:Product_80df9e94-ee60-3921-a952-9cd7b81e01e6 _:B6e9ca4c651201e649bde5a6703456586|imgt:isDecidedBy|imgt:FDA imgt:Construct_1090|rdfs:label|Construct_1090 imgt:Product_4eeaa614-ef03-3234-84a9-d2d1c82a6455|imgt:comercial_name|ARZERRA® imgt:mAb_122|rdf:type|imgt:INN imgt:PROTEIN_1DOMAIN_683|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/PROTEIN_1DOMAIN.png imgt:Segment_894_1|rdfs:label|Segment_894_1 _:Beed3b5cdaa2425c8b20c23d28a4f5d43|imgt:isDecidedBy|imgt:FDA imgt:Severe_acute_respiratory_syndrome_coronavirus_2_(SARS-CoV-2)_infection_(COVID-19)|imgt:isClinicalIndicationOf|imgt:StudyProduct_49dfd581-e83a-319a-8e18-6cf9e4b527c4 imgt:StudyProduct_9937caad-f7d1-3094-978d-bf1219411187|rdfs:label|StudyProduct_9937caad-f7d1-3094-978d-bf1219411187 imgt:N-GLYCOSYLATION-MOT|rdf:type|imgt:RegulationLabel imgt:IgG1-kappa_662|obo:RO_0002162|imgt:Hum imgt:Segment_164_1|imgt:hasImgtLabel|imgt:IgG1-nd imgt:StudyProduct_f9d091c1-0d73-3ff4-b753-7ffab31fd62b|rdf:type|obo:NCIT_C174271 imgt:Segment_1288_1|rdf:type|imgt:Segment imgt:mAb_272|rdfs:label|mAb_272 imgt:StudyProduct_3e0a6029-f7fb-3cc4-b507-166eb0790d1f|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:Product_20b6d3b5-9b57-3faf-8a71-7c264afd5776|imgt:commun_name|ISU-104 imgt:IgG2-kappa_196|imgt:isMabReceptorOf|imgt:mAb_196 imgt:StudyProduct_6e0d7ab7-1246-3ec0-adef-e0cc395836aa|imgt:hasClinicalIndication|imgt:Neuromyelitis_optica_(NMO) imgt:mAb_925|imgt:hasProduct|imgt:Product_69126e38-2f0c-3448-b499-cabc3ca17145 imgt:StudyProduct_c93d5477-8120-313a-86b7-5b1befbe0ef3|rdf:type|obo:NCIT_C174271 imgt:IgG1-kappa-S239C_2cys-drug_902|obo:RO_0002162|imgt:Hum imgt:Cancers_testicular|imgt:isClinicalIndicationOf|imgt:StudyProduct_77a24d4f-800e-3887-ac4b-f8b7ceba87c7 imgt:Segment_1192_1|rdf:type|imgt:Segment imgt:GH1*01(Pr27-217)|rdfs:label|GH1*01(Pr27-217) imgt:mAb_1145|imgt:inn_number|11649 imgt:StudyProduct_7b861a94-9e6b-3cac-af47-59cbb1fad6a4|rdfs:label|StudyProduct_7b861a94-9e6b-3cac-af47-59cbb1fad6a4 imgt:IgG1-kappa_1033|http://semanticscience.org/resource/SIO_000291|imgt:TNFRSF4 imgt:Segment_1010_1|rdf:type|imgt:Segment imgt:FR1-IMGT|rdf:type|imgt:FRLabel imgt:9233|imgt:isImgtStructureEntryOf|imgt:mAb_334 imgt:Product_6a160c4a-db89-347f-a136-7e561bce3c0f|imgt:isProducedBy|imgt:Xenikos_BV imgt:Product_73d7ad4c-b6ea-323f-9ed4-f75c83e0c600|imgt:commun_name|Sym 004 (combination of modotuximab and futuximab) imgt:Bristol-Myers_Squibb|imgt:produces|imgt:Product_f4aba402-2987-38e9-bc54-e9bacc917b27 imgt:PSI|rdfs:label|PSI imgt:Segment_933_2|imgt:has_rank|2 imgt:Product_ba43734d-62ba-3121-bacd-1df363311834|imgt:isProducedBy|imgt:Checkpoint_Therapeutics imgt:shiga_toxin_type_2|imgt:isTargetOf|imgt:IgG1-kappa_265 imgt:CCL11|rdfs:label|CCL11 imgt:Segment_73_1|obo:BFO_0000050|imgt:Construct_73 imgt:IgG1-kappa_168|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:Construct_700|obo:BFO_0000051|imgt:Segment_700_2 imgt:Construct_647|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:9841|imgt:isImgtStructureEntryOf|imgt:mAb_484 imgt:Clone_296|obo:RO_0002162|imgt:Homsap imgt:StudyProduct_1b8c3e38-fc16-35dc-9bdf-272dc77ca40b|imgt:hasClinicalPhase|imgt:Phase_I imgt:StudyProduct_05289ac9-e124-37fb-b382-3c58fb3a6759|rdfs:label|StudyProduct_05289ac9-e124-37fb-b382-3c58fb3a6759 imgt:IgG2-kappa_954|rdf:type|imgt:MAbReceptor imgt:Construct_534|obo:BFO_0000051|imgt:Segment_534_1 imgt:(VH-CH2-CH3)2_S_934|imgt:hasMolecularComponent|imgt:IG imgt:StudyProduct_e4eea69e-43e4-3e5d-aef6-5c28239018ea|imgt:isStudyProductOf|imgt:Product_6a18513a-d0e4-37c5-80b2-122a63ee4ba2 imgt:PSCA|rdf:type|obo:NCIT_C25702 imgt:F(ab’)2-Epsilon_Kappa|rdf:type|imgt:ReceptorType imgt:VH-VH%27-VH__trivalent_971|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/VH-VH'-VH,%20trivalent.png imgt:IG-GAMMA-2-A_LAMBDA|rdfs:label|IG-GAMMA-2-A_LAMBDA imgt:IG-GAMMA-2C_LAMBDA|rdf:type|imgt:IGCompleteReceptorLabel imgt:Solid_tumors|imgt:isClinicalIndicationOf|imgt:StudyProduct_e71f82cd-4d55-3f0e-bac1-74d5fa41efb3 imgt:11274|imgt:isImgtStructureEntryOf|imgt:mAb_1049 imgt:StudyProduct_500fe82b-fc21-36e0-9c3c-fca5c48da3eb|imgt:application_type|Diagnostic imgt:mAb_1184|rdfs:label|mAb_1184 imgt:StudyProduct_dcb34807-4868-33f7-b1ca-f367fbeefcbc|imgt:hasDecision|_:Be7334b9835ecb2faf2a099d90a1a005a imgt:IgG1-kappa_553|imgt:hasMolecularComponent|imgt:IG imgt:FN1-5|rdf:type|imgt:Fibronectin-1Label imgt:MAbReceptor_32|imgt:isMabReceptorOf|imgt:mAb_32 imgt:StudyProduct_90fd282e-02f9-398a-be74-6e57271986c8|imgt:hasClinicalIndication|imgt:Axial_spondyloarthritis_(axSpA) imgt:Clone_133|rdf:type|obo:NCIT_C37925 imgt:MH-Gene|rdfs:subClassOf|imgt:Gene imgt:mAb_590|imgt:hasOriginClone|imgt:Clone_590 imgt:Product_bfe2fe91-b07e-31f5-bde7-34f768c8f3f3|imgt:hasStudyProduct|imgt:StudyProduct_25470ec4-f4d3-3cc4-991e-7ba070dc3aea imgt:IG-Heavy-Delta-IGHD|imgt:hasChainTypeLevel|imgt:IG-Heavy-Delta imgt:Construct_734|rdf:type|imgt:Construct imgt:StudyProduct_4495f259-8824-3877-b42f-dde6cabec1b7|rdf:type|obo:NCIT_C174271 imgt:mAb_566|rdf:type|imgt:INN imgt:mAb_764|imgt:hasImgtStructureEntry|imgt:10639 imgt:Product_00890ef7-c752-3fa4-98ed-dcfff088e354|imgt:commun_name|BH2950 imgt:StudyProduct_6c878ada-1306-3956-b6b2-ee886b0c2e29|imgt:hasClinicalIndication|imgt:Cancers_gastric imgt:10114|rdfs:label|10114 imgt:Daiichi_Sankyo_Inc|imgt:produces|imgt:Product_e759fefd-9101-3729-bd7b-5f4394e694e6 _:B58001b9560ca4acb2799f29da114009b|imgt:hasStatut|imgt:approval imgt:Product_f36504b9-7a54-3056-b3e8-26781525dfe1|imgt:commun_name|V3 imgt:mAb_613|imgt:hasProduct|imgt:Product_d83f11d1-0413-38d7-9027-724429ec0e9f imgt:Crohn's_disease_(CD)|imgt:isClinicalIndicationOf|imgt:StudyProduct_6bae9e91-12f7-3b99-89d5-7e63a5f2d57e imgt:mAb_82|imgt:hasMabReceptor|imgt:%5BCD4-H-Gamma2_CD4-C-kappa%5D-dimer_82 imgt:StudyProduct_b87ee559-aea6-37ce-82b5-a1c9e1c007a2|imgt:application_type|Therapeutic imgt:Cancers_non-small_cell_lung_(NSCLC)|imgt:isClinicalIndicationOf|imgt:StudyProduct_ff02fdb0-13d8-318a-af5f-902f811d122b imgt:Fracture_healing|rdfs:label|Fracture_healing imgt:mAb_671|imgt:hasImgtStructureEntry|imgt:6510 imgt:StudyProduct_3af4fc94-a470-31a6-b10b-f0a9c38ec2f9|imgt:hasClinicalPhase|imgt:Phase_II imgt:Product_60d50ddc-7055-3124-936b-1628e2af1236|imgt:commun_name|F(ab)-12 IgG1 imgt:Product_a05390bf-1495-3785-a5b6-edf17b39170e|imgt:commun_name|GA-501 imgt:Segment_772_1|rdf:type|imgt:Segment obo:NCIT_C169767|rdfs:subClassOf|obo:NCIT_C1909 imgt:Segment_1271_1|imgt:has_rank|1 imgt:Segment_641_1|rdf:type|imgt:Segment imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_dab25960-187a-3ef7-8541-9922a9f0c26b imgt:GUCY2C|obo:RO_0002162|imgt:Homsap imgt:StudyProduct_2e17b2e2-7238-381e-b471-370897d5c9e4|imgt:isStudyProductOf|imgt:Product_6d00b4b8-121c-3156-854d-ae9f08aba45a imgt:IgG1-kappa_MM_108|imgt:hasConstruct|imgt:Construct_108 imgt:IgG4-kappa-lambda_1183|http://semanticscience.org/resource/SIO_000291|imgt:FOLH1 imgt:StudyProduct_fe683cf1-3e60-38cf-9475-d6d80b127665|imgt:application_type|Therapeutic imgt:StudyProduct_dab25960-187a-3ef7-8541-9922a9f0c26b|imgt:hasClinicalPhase|imgt:Phase_II imgt:mAb_590|rdf:type|imgt:INN imgt:Segment_896_1|imgt:has_rank|1 imgt:mAb_1106|imgt:inn_name|cilgavimab pubmed:12359774|dc:contributor|Fukuda T imgt:Segment_703_1|rdf:type|imgt:Segment imgt:StudyProduct_e4eea69e-43e4-3e5d-aef6-5c28239018ea|imgt:application_type|Therapeutic imgt:Segment_863_1|imgt:hasImgtLabel|imgt:IgG4-kappa imgt:mAb_653|imgt:hasImgtStructureEntry|imgt:10365 imgt:Novartis_Pharmaceuticals_Corp|imgt:produces|imgt:Product_27f37a2c-626d-3660-be9f-abc0020e4b15 imgt:StudyProduct_322aeb8c-670b-31bd-b097-1ebce08e7478|rdfs:label|StudyProduct_322aeb8c-670b-31bd-b097-1ebce08e7478 imgt:StudyProduct_f3cb0d51-0ece-38b1-a867-a2fde28d62a3|imgt:hasClinicalIndication|imgt:Crohn's_disease_(CD) obo:NCIT_C82406|rdfs:subClassOf|obo:NCIT_C1909 imgt:EGFR|rdf:type|obo:NCIT_C25702 imgt:Fab-Alpha-1_Kappa|rdf:type|imgt:ReceptorType imgt:StudyProduct_d8d8bce1-46d4-3206-938f-d51e1184816b|imgt:hasDecision|_:Bb73867cc079e3ab87e7870354099e9e7 imgt:Alphamab_CoLtd|rdfs:label|Alphamab Co.,Ltd imgt:Product_d435ac5c-4b8d-3683-9fae-ecfcb9abc376|imgt:commun_name|IMGN529 imgt:CARRIER_BIG-PROTEIN_1DOMAIN_692|rdfs:comment|CARRIER_BIG-PROTEIN_1DOMAIN imgt:IgG1-nd_2|http://semanticscience.org/resource/SIO_000291|imgt:SFRP1 imgt:10536|imgt:isImgtStructureEntryOf|imgt:mAb_727 imgt:Neurimmune|imgt:produces|imgt:Product_22ec6ed9-ddd5-3fc9-bb08-2d8f3efa3145 imgt:Construct_954|rdfs:label|Construct_954 imgt:Segment_843_1|rdfs:label|Segment_843_1 imgt:ziextenzo™|rdf:type|obo:NCIT_C156644 _:B32e226c498779057b9c076c492fa3245|imgt:hasDesignation|imgt:Orphan_drug imgt:StudyProduct_3da0db8d-1eec-321a-9900-792118d84944|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:Segment_249_1|obo:BFO_0000050|imgt:Construct_249 imgt:Clone_295|imgt:isOriginCloneOf|imgt:mAb_295 imgt:Takeda_Pharmaceuticals_USA_Inc|rdfs:label|Takeda Pharmaceuticals U.S.A., Inc. imgt:Construct_748|rdf:type|imgt:Construct imgt:mAb_1052|rdfs:label|mAb_1052 _:B5677f9e365577d65348d2381ea77913f|imgt:isDecidedBy|imgt:FDA imgt:StudyProduct_be59984e-2e11-35c7-91d3-05fc86caef5e|rdf:type|obo:NCIT_C174271 imgt:mAb_99|imgt:hasProduct|imgt:Product_56e1aba5-d1fa-3556-89ad-76c1dd577359 imgt:Product_2046a78d-ba5a-3908-949c-c2d69a5bb46a|imgt:commun_name|KW-0761 imgt:StudyProduct_6da5c90c-7d49-340d-89f5-e40e28b71aea|rdfs:label|StudyProduct_6da5c90c-7d49-340d-89f5-e40e28b71aea imgt:mAb_1037|imgt:hasMabReceptor|imgt:IgG4-kappa_1037 imgt:IgG4-kappa_1121|rdfs:label|IgG4-kappa_1121 imgt:Product_85bf09db-dcaa-3c16-83c2-0e68aaabd997|imgt:hasStudyProduct|imgt:StudyProduct_5e4004b3-1015-3051-a220-2854ddad8641 _:B2901adce123595f06b05e84dc8a91550|dc:date|2017-06-15 imgt:StudyProduct_9b3dd0f9-56f2-3a5d-9452-a0310c985e83|rdfs:label|StudyProduct_9b3dd0f9-56f2-3a5d-9452-a0310c985e83 imgt:mAb_60|imgt:hasOriginClone|imgt:Clone_60 imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_85da48ac-fe22-3b3d-8f2b-9949bbfef548 imgt:Clone_81|rdfs:label|Clone_81 imgt:IgG4-kappa_1128|rdfs:comment|IgG4 - kappa imgt:Merck_&_Co_Inc|imgt:produces|imgt:Product_c7cf4dec-df13-33c9-9a7e-798c0993539c 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imgt:Osteomalacia_oncogenic|rdf:type|obo:NCIT_C185637 imgt:Product_64290ba9-0505-3e73-bd11-364751196aba|rdfs:label|Product_64290ba9-0505-3e73-bd11-364751196aba imgt:IgG1-kappa_713|obo:RO_0002162|imgt:Chi imgt:mAb_1174|imgt:hasProduct|imgt:Product_7206ce92-2c30-3a53-96b4-d2f0bd2f1dd3 imgt:prevention_of_feto-maternal_allo-immunization_in_RhD-_women|imgt:clinical_domain|Immunology imgt:Construct_985|imgt:hasImgtLabel|imgt:TR-Alpha_Beta-2 imgt:mAb_903|imgt:inn_recommended_list|82 (2019) imgt:StudyProduct_8d208b80-c17f-31ca-8b2b-5b074a0c7dcd|imgt:isStudyProductOf|imgt:Product_419876d7-c157-30b2-b42a-6232519b26b0 imgt:Segment_1170_1|obo:BFO_0000050|imgt:Construct_1170 imgt:Kodiak_Sciences_USA|rdfs:comment|Palo Alto , USA imgt:StudyProduct_c286e60e-41e0-36d5-b2cb-d414b008e43d|rdf:type|obo:NCIT_C174271 imgt:Product_a3c9d665-6135-3ace-a49a-560364fbe5be|imgt:hasStudyProduct|imgt:StudyProduct_47c83720-4471-39cc-b0d4-0aa7d46fe8da imgt:IgG1-kappa_223|imgt:hasConstruct|imgt:Construct_223 imgt:Product_0872db0d-9d18-336b-aa58-45b3210cb065|imgt:hasStudyProduct|imgt:StudyProduct_b2d959f6-4ef0-3b93-80d4-43afe5dbb1a7 imgt:IgG1-lambda_262|imgt:hasMolecularComponent|imgt:IG imgt:Canlupfam_NGF|imgt:isTargetOf|imgt:IgG2-lambda_924 imgt:IgG1-kappa_1105|rdfs:comment|IgG1 - kappa imgt:FUSION-H-GAMMA-1-IL2|skos:definition|H-GAMMA-1 fused with IL2 imgt:mAb_1072|imgt:hasImgtStructureEntry|imgt:11416 imgt:mAb_484|imgt:hasMabReceptor|imgt:IgG2-kappa_484 obo:NCIT_C121540|rdf:type|owl:Class _:Bbc4858d69ee31006a2a3bfbdc26b94d0|imgt:isDecisionOf|imgt:StudyProduct_d7f19d8a-4189-35e7-a73c-23e92d344117 imgt:Product_1ff282bc-eb72-3378-9c95-2ad8aac8ba1d|imgt:isProducedBy|imgt:Millennium_Pharmaceuticals_Inc imgt:mAb_619|imgt:inn_proposed_list|119 (2018) imgt:Construct_544|rdfs:label|Construct_544 imgt:Product_65f1a583-9ab6-38d8-8b26-1a11dfa24b99|imgt:hasStudyProduct|imgt:StudyProduct_78d0ac92-bd27-3b92-ab3b-d6fb6611cc7e imgt:StudyProduct_f0b8db0f-c770-338b-9507-40d0d2a0c9b3|imgt:hasClinicalIndication|imgt:Myelodysplastic_syndromes_(MDS) imgt:Construct_683|obo:BFO_0000051|imgt:Segment_683_1 imgt:CX3CL1|obo:RO_0002162|imgt:Homsap imgt:Segment_919_1|obo:BFO_0000050|imgt:Construct_919 imgt:Segment_1282_1|rdfs:label|Segment_1282_1 imgt:IgG4-kappa_898|rdf:type|imgt:MAbReceptor imgt:StudyProduct_393a9101-6f44-3cff-855c-d1a42fcc9d31|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:%5BTNFSF18_(TNF_superfamily_member_18_AITRL_TL6_GITRL)%5D2-IGHG1_Fc_(Fragment_constant)|imgt:construction_detail|Fusion - [TNFSF18 (TNF superfamily member 18, AITRL, TL6, GITRL)]2 - IGHG1 Fc (Fragment constant) imgt:D-sequence|imgt:hasConfigurationType|imgt:G imgt:mAb_621|imgt:hasImgtStructureEntry|imgt:10303 imgt:mAb_448|imgt:inn_name|evolocumab _:Bf0e4e75f54c13c0d033c3974705d2678|rdf:type|obo:NCIT_C53285 imgt:Construct_393|imgt:isConstructOf|imgt:FC-%5BPEPTIDE-PEPTIDE%5D2_393 imgt:Product_4384026e-ba8b-350f-b05f-d196a99c173c|rdfs:label|Product_4384026e-ba8b-350f-b05f-d196a99c173c imgt:Medarex|imgt:produces|imgt:Product_f01e8205-2d54-3f91-849d-e8708ee470b7 imgt:Construct_1230|obo:BFO_0000051|imgt:Segment_1230_1 _:Ba99aea26187015f3fd5d93c37bc24e64|rdf:type|obo:NCIT_C53285 imgt:Product_f4fd9a30-eef7-3bcb-a2d0-e163992e5369|rdfs:label|Product_f4fd9a30-eef7-3bcb-a2d0-e163992e5369 _:Bb24ef3b76039e50d7e7ea7af4178c1d4|dc:date|2005-04-28 imgt:Adult_T_cell_leukemia/lymphoma_(ATL)|imgt:clinical_domain|Oncology imgt:Hepatocellular_carcinoma_(HCC)|rdf:type|obo:NCIT_C185637 imgt:CO-PART1|rdfs:label|CO-PART1 imgt:Cancers_non-small_cell_lung_(NSCLC)|imgt:isClinicalIndicationOf|imgt:StudyProduct_1fb6363e-1126-3c35-9f7a-641a367792e6 imgt:PRE-TCR|rdf:type|imgt:RPILabel imgt:IgG1-kappa_1252|imgt:hasMolecularComponent|imgt:IG imgt:Product_29519aab-8c0a-3e53-8eea-8f07f4fc346a|imgt:hasStudyProduct|imgt:StudyProduct_94c0040f-b4c8-3e29-9d30-5d34c53c3c22 imgt:Construct_707|rdf:type|imgt:Construct imgt:mAb_455|imgt:clinical_trials|13 studies found, 1 recruiting imgt:PROTEIN_1DOMAIN-PEG_616|imgt:conjugated_with| pegol imgt:IgG1-nd_680|rdfs:comment|IgG1 - nd imgt:StudyProduct_6a412ddc-a257-3bc8-bee2-46b40c60a237|rdfs:label|StudyProduct_6a412ddc-a257-3bc8-bee2-46b40c60a237 imgt:StudyProduct_08c22142-db46-3298-b221-05fa460a0128|imgt:hasDecision|_:B9d6d63ba48c67a0d27638a70fb7ef1ff imgt:StudyProduct_08b9cb90-6d16-3be4-9762-c96c5f4f1501|imgt:isStudyProductOf|imgt:Product_32b86460-a45e-3754-b094-c62785f30884 imgt:StudyProduct_1d4d92a6-c2bc-30e8-b38e-2f674fdd2e06|imgt:application_type|Therapeutic imgt:CPCA_PEPTIDE-PEG-FC_673|obo:RO_0002162|imgt:Helsus imgt:Product_4ecbc6e7-591c-327e-83d0-e2f2e4a2a07d|rdfs:label|Product_4ecbc6e7-591c-327e-83d0-e2f2e4a2a07d imgt:Segment_383_1|imgt:has_rank|1 imgt:IgG1-kappa_551|rdfs:label|IgG1-kappa_551 imgt:Product_9167f067-90ce-3085-a54d-a51746667cfb|imgt:commun_name|PRO-140 imgt:inflectra™|imgt:isBiosimilarOf|imgt:mAb_156 imgt:Segment_1260_2|obo:BFO_0000050|imgt:Construct_1260 imgt:Product_56e1aba5-d1fa-3556-89ad-76c1dd577359|rdf:type|obo:NCIT_C51980 imgt:mAb_891|imgt:hasImgtStructureEntry|imgt:10919 imgt:Product_39ec5d7e-7e56-320e-81b0-dd2a88a3adf0|imgt:hasStudyProduct|imgt:StudyProduct_c3bac2e0-465b-3fba-bcf3-be022b1e732e imgt:StudyProduct_c951f76e-4f06-3ee7-9142-fae30dd7a065|rdfs:label|StudyProduct_c951f76e-4f06-3ee7-9142-fae30dd7a065 imgt:StudyProduct_11b9842e-0a27-3ff2-92c1-903e7132cd68|rdf:type|obo:NCIT_C174271 imgt:Segment_288_2|imgt:hasImgtLabel|imgt:IGHG1 imgt:mAb_64|imgt:hasOriginClone|imgt:Clone_64 imgt:StudyProduct_3ff2cb83-f81b-3da6-9128-579440ac058a|rdfs:label|StudyProduct_3ff2cb83-f81b-3da6-9128-579440ac058a imgt:StudyProduct_a2cf14ef-242a-32b4-817c-814f3fcb2e78|rdf:type|obo:NCIT_C174271 imgt:TR-BETA-1|imgt:describes|imgt:TR-Beta-1-TRBC1 imgt:Complement_component_deficiency|imgt:isClinicalIndicationOf|imgt:StudyProduct_7074878e-5024-3517-aad8-1d22b5ae0f39 imgt:StudyProduct_2e1627be-7d57-3081-b019-6d6815084712|imgt:application_type|Therapeutic imgt:mAb_604|rdfs:label|mAb_604 imgt:Mucopolysaccharidosis_I_(MPSI)|imgt:isClinicalIndicationOf|imgt:StudyProduct_169d962c-e3d7-30e3-a52c-5cf35ed5fff0 imgt:StudyProduct_bf9c4751-a32e-3ad6-a1c3-f8822432d8d2|rdf:type|obo:NCIT_C174271 imgt:mAb_224|rdf:type|obo:NCIT_C71015 imgt:StudyProduct_dbd9c39c-f335-3893-9973-0b460a8f03fa|rdfs:label|StudyProduct_dbd9c39c-f335-3893-9973-0b460a8f03fa imgt:Product_1aaa2a7e-6eb9-3729-a3c8-9ebd6913b871|imgt:commun_name|anti-TSLP-Receptor (TSLP-R; Crl2) imgt:Construct_1029|rdfs:label|Construct_1029 imgt:Product_1b93be2b-0d55-3628-845a-afdbb028443f|rdfs:label|Product_1b93be2b-0d55-3628-845a-afdbb028443f obo:NCIT_C66582|rdf:type|owl:Class imgt:Adult_T_cell_leukemia/lymphoma_(ATL)|imgt:isClinicalIndicationOf|imgt:StudyProduct_e027ab59-74de-3238-8f49-45275ebb305b imgt:StudyProduct_7203423a-8a25-3a39-963b-82f12d06aea0|imgt:hasClinicalIndication|imgt:Cancers_gastric imgt:Product_ae26fe5d-0957-3750-9fd4-e84dc4303b03|imgt:commun_name|cirmtuzumab imgt:mAb_244|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=244 imgt:IgG2-kappa_586|imgt:isMabReceptorOf|imgt:mAb_586 imgt:Construct_268|imgt:isConstructOf|imgt:IgG1-nd_MM_268 imgt:mAb_33|rdf:type|obo:NCIT_C1909 imgt:Regeneron_Pharmaceuticals_Inc|imgt:produces|imgt:Product_971c8e9f-b2e9-3a2b-81cf-ec9cc91e320b imgt:Product_d0ab5070-db16-3ae6-b607-37ad63abcbcc|rdfs:label|Product_d0ab5070-db16-3ae6-b607-37ad63abcbcc _:Bd130e1519d830b4742b49c00630262d0|imgt:isDecidedBy|imgt:FDA imgt:Product_98a3e0f3-b097-3350-b298-3d2f113181b0|imgt:isProducedBy|imgt:Sinocelltech_Ltd imgt:Product_df08d729-eee9-3267-b396-c4c3480ef28b|imgt:hasStudyProduct|imgt:StudyProduct_aed1894e-85c8-30fe-9928-aa2ec48a80f4 imgt:mAb_216|imgt:hasProduct|imgt:Product_33c97ddf-49a2-3444-885e-824d06bac68c imgt:BETA-ALPHA1_987|obo:RO_0002162|imgt:Homsap imgt:StudyProduct_69613c5b-ad4f-3679-a3c1-32124318d3f8|imgt:development_technology| Medarex’s UltiMAb® imgt:Segment_560_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Segment_499_1|imgt:has_rank|1 imgt:Melanoma|imgt:isClinicalIndicationOf|imgt:StudyProduct_89ad5c02-180f-3502-8e7e-d5abc65f569c imgt:StudyProduct_115bc04d-cd5b-3146-9ec7-c78e72875181|imgt:hasClinicalPhase|imgt:Phase_I imgt:Novo_Nordisk|rdf:type|obo:NCIT_C54131 imgt:Product_3086b99e-8c37-3a44-8aaf-14e046e82b3b|imgt:hasStudyProduct|imgt:StudyProduct_07f88f08-8bb3-39d1-8416-508d41a38406 imgt:SIGLEC8|skos:definition|SIGLEC8 (sialic acid binding Ig like lectin 8, sialic acid binding Ig-like lectin 8, MGC59785, SAF2, SIGLEC-8, SIGLEC8L) imgt:Asthma|imgt:isClinicalIndicationOf|imgt:StudyProduct_6fab05c0-87cb-30fa-b215-f67f8886e4ab imgt:mAb_1022|imgt:hasImgtStructureEntry|imgt:11310 imgt:StudyProduct_00ad372a-0d4f-39a5-900f-438420dc71ea|imgt:isStudyProductOf|imgt:Product_e9725593-72db-3005-b841-06e3fc3b71a1 _:Bb0c4ec91ea6d956b9a43ef16860d91a9|rdf:type|obo:NCIT_C53285 imgt:Clone_603|obo:RO_0002162|imgt:Musmus imgt:Product_96905c13-ffcf-3341-aed9-29326be6e91d|imgt:isProducedBy|imgt:MRC_Laboratory_of_Molecular_Biology _:B17b55de5399efbc86eea66f248de90c6|imgt:isDecidedBy|imgt:Japan_(MHLW) imgt:Segment_546_1|obo:BFO_0000050|imgt:Construct_546 imgt:IL13RA1|imgt:isTargetOf|imgt:IgG4-kappa_1210 imgt:1V-1C-LIKE_1V-LIKE|skos:definition|Receptor comprising two chains, one with a V-LIKE and a C-LIKE domains and the other with a V-LIKE domain imgt:mAb_1248|imgt:inn_name|emfizatamab imgt:IL1RL1|rdf:type|obo:NCIT_C25702 imgt:Melanoma_metastatic_or_unresectable|imgt:isClinicalIndicationOf|imgt:StudyProduct_feae6a22-c82c-3d95-9134-7ab7f653eba9 imgt:11039|rdf:type|obo:NCIT_C25402 imgt:Segment_97_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Beta_thalassemia_(Cooley’s_anemia)|imgt:clinical_domain|Hematology imgt:Product_e71972eb-fe86-3835-944b-ec9b77978c50|imgt:commun_name|NeutroSpec imgt:Product_2527517c-0a7a-3f6a-b4c5-fff6e5f2d499|imgt:isProducedBy|imgt:ImClone_Systems_Inc imgt:mAb_432|imgt:hasProduct|imgt:Product_78eebd3e-f8c8-3948-963d-3585de3125e3 imgt:Product_f4aba402-2987-38e9-bc54-e9bacc917b27|imgt:hasStudyProduct|imgt:StudyProduct_ceb7772c-4230-3f78-9b92-e823888f62fb imgt:mAb_1068|imgt:hasProduct|imgt:Product_d3c2662f-9244-388c-aa91-aa125c885265 imgt:11137|rdf:type|obo:NCIT_C25402 imgt:Clone_279|obo:RO_0002162|imgt:Ratsp. imgt:IgG1-kappa_328|obo:RO_0002162|imgt:Chi imgt:Chugai_Pharmaceutical_Co_Ltd|imgt:produces|imgt:Product_ae24c953-5ef0-3ff3-9d24-34f1a89ee93f imgt:Segment_803_1|rdfs:label|Segment_803_1 imgt:Segment_937_1|obo:BFO_0000050|imgt:Construct_937 _:Bd3110e9f41efc15d28ebdbac7ba3b8fb|imgt:isDecidedBy|imgt:FDA imgt:Segment_454_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:IG-ALPHA_KAPPA|rdf:type|imgt:StructureLabels imgt:Anemia|imgt:isClinicalIndicationOf|imgt:StudyProduct_866e45f8-bfed-34b8-accf-51cb795897b9 imgt:mAb_560|rdf:type|obo:NCIT_C166491 imgt:Product_792c9a29-fe82-3435-90da-504b22106ca9|imgt:hasStudyProduct|imgt:StudyProduct_493e2fe7-7cc7-3bf7-8f5d-f255a8d4b409 imgt:mAb_447|imgt:inn_number|9636 imgt:AbbVie_Inc|imgt:produces|imgt:Product_52d64598-ed50-3201-a067-7767d7a82e62 pubmed:2843774|dc:contributor|FitzGerald DJ imgt:Factor_substitute|imgt:isTargetOf|imgt:ENZ_1DOMAIN_1047 obo:NCIT_C104260|rdfs:subClassOf|obo:NCIT_C1909 imgt:10621|rdf:type|obo:NCIT_C25402 imgt:StudyProduct_ba5846bc-9689-3122-b3c1-045007a7f673|imgt:hasClinicalIndication|imgt:Solid_tumors imgt:Psoriasis_pediatric|rdfs:label|Psoriasis_pediatric _:B7ebc41a6b98e28205c6bbbb2f8f6c680|dc:date|2014-12-03 imgt:%5BscFv-kappa-heavy-PROT%5D2_796|imgt:isMabReceptorOf|imgt:mAb_796 imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_ebcac4d8-7f2c-3e2f-8ee7-1464fc760694 imgt:StudyProduct_40ffcbf7-63af-365e-b8de-1fef7954cc01|imgt:hasClinicalPhase|imgt:Phase_III imgt:StudyProduct_5893f77a-8ead-33d5-accb-55e4c2563b5d|imgt:hasClinicalPhase|imgt:Phase_I imgt:JW_Therapeutics|imgt:produces|imgt:Product_04ac483d-3770-31ee-be76-21b370f3667d imgt:Construct_149|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:mAb_1264|imgt:inn_name|litifilimab imgt:StudyProduct_46ba9f2a-6976-370b-8353-203ec4474217|imgt:isStudyProductOf|imgt:Product_46ba9f2a-6976-370b-8353-203ec4474217 imgt:mAb_912|imgt:hasImgtStructureEntry|imgt:10993 imgt:StudyProduct_193a5cb7-6d02-39c0-908f-de2bd30cecd3|imgt:application_type|Therapeutic _:B6982ca1cacfe030f2400e3b5ff18ed97|imgt:isDecidedBy|imgt:FDA imgt:Product_e3686309-2689-3dcf-a5f8-b6119a1bb380|imgt:hasStudyProduct|imgt:StudyProduct_811a510e-cdbc-366f-984f-6ee8aafee53d imgt:Product_2cc853dd-e3c6-3e19-a19e-85aa74315a15|imgt:isProductOf|imgt:mAb_516 imgt:mAb_1136|rdfs:label|mAb_1136 imgt:Rheumatoid_arthritis_(RA)|imgt:isClinicalIndicationOf|imgt:StudyProduct_2394b2ec-3d78-30aa-a147-6fca07f60040 imgt:_LAG-3-immunized_KM®|imgt:isExpressionSystemOf|imgt:StudyProduct_0fde7fe1-e260-3c20-9361-f9caebe22024 imgt:aybintio®|imgt:isBiosimilarOf|imgt:mAb_24 imgt:Product_2cb15a3e-feff-380a-a4cd-ce375f581bfc|rdf:type|obo:NCIT_C51980 pubmed:12180488|dc:title|Clinical effects of alemtuzumab (Campath-1H) in B-cell chronic lymphocytic leukemia. imgt:IgG4-kappa_609|imgt:isMabReceptorOf|imgt:mAb_609 imgt:mAb_1113|imgt:inn_name|efmarodocokin alfa imgt:Product_b0125efb-d294-356b-81c9-df23c973888d|imgt:isProducedBy|imgt:EpimAb_Biotherapeutics imgt:11647|imgt:isImgtStructureEntryOf|imgt:mAb_1149 imgt:StudyProduct_798de131-ed3d-32b5-98df-955db52f62c0|rdf:type|obo:NCIT_C174271 imgt:Segment_707_1|imgt:hasImgtLabel|imgt:INS imgt:V-D-J-C-CLUSTER|skos:definition|genomic DNA of an IG or TR locus, in germline configuration, including at least one V-GENE, one D-GENE, one J-GENE and one C-GENE imgt:Clone_594|imgt:isOriginCloneOf|imgt:mAb_594 imgt:IgG4-kappa_948|rdfs:label|IgG4-kappa_948 imgt:_CHOK1SV_(lacking_the_glutamine_synthetase_(GS)_gene)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_d811f4a9-53dd-3953-b036-55fba677f99a imgt:IgG1-kappa_1181|http://semanticscience.org/resource/SIO_000291|imgt:bispecific imgt:Segment_674_1|rdf:type|imgt:Segment imgt:FOLH1|imgt:isTargetOf|imgt:IgG1-kappa_1276 imgt:StudyProduct_1ea82c62-b6a1-32b1-bd9e-fb92e540f9ab|rdfs:label|StudyProduct_1ea82c62-b6a1-32b1-bd9e-fb92e540f9ab imgt:mAb_1235|imgt:imgt_note| PRM-151 is developed by PROMEDIOR for fibrotic diseases. On Feb. 13, 2020, Promedior , Inc. announced the successful completion of its sale to Roche (SIX: RO, ROG; OTCQX: RHHBY). With this acquisition, Roche obtained full rights to Promedior's entire portfolio of molecules for serious fibrotic diseases, notably PRM-151. obo:NCIT_C148535|rdfs:subClassOf|obo:NCIT_C1909 imgt:VH-VH|rdfs:label|VH - VH' imgt:StudyProduct_132c53a3-6899-367b-b1e6-9d1015288b30|imgt:isStudyProductOf|imgt:Product_1e6dcbf5-881e-3dae-a9c2-c7d5ca5aaceb imgt:StudyProduct_b9c1c916-5714-3827-9cc3-e400f7b2e42c|rdf:type|obo:NCIT_C174271 imgt:PROTEIN_2DOMAINS_VLIKE_CLIKE-TOXIN_2DOMAINS_289|rdfs:comment|PROTEIN_2DOMAINS_VLIKE_CLIKE-TOXIN_2DOMAINS imgt:Cancers_lung|imgt:isClinicalIndicationOf|imgt:StudyProduct_915b5f50-b0b1-32e8-bfe4-41f3900cc292 imgt:V-LAMBDA-CH1_VH-C-KAPPA|skos:definition|IG receptor comprising a V-LAMBDA-CH1 and a VH-C-KAPPA chains imgt:StudyProduct_0c23c19c-5024-3083-90b4-416d2c92751d|imgt:hasDecision|_:B4d3a0dc77235eca0cc3ef10e29559613 imgt:Segment_1231_1|imgt:has_rank|1 imgt:Thyroid_eye_disease_(TED)|imgt:isClinicalIndicationOf|imgt:StudyProduct_a4a7bca6-26d4-3a2d-b63d-927b4e781968 imgt:mAb_360|imgt:inn_number|9354 imgt:StudyProduct_b9617fc0-a404-3cff-ac56-94d20bcda253|imgt:isStudyProductOf|imgt:Product_8bdb3425-f72a-3777-be41-82fdaed26099 imgt:ENZ-CTP_698|rdfs:comment|ENZ-CTP imgt:Product_be7fe1ac-60ec-3e93-a36a-4383c0cb79ad|imgt:commun_name|DuoHexaBody-CD37 imgt:mAb_142|rdfs:label|mAb_142 imgt:StudyProduct_bb502ee3-e64f-37f4-8ad4-4af1f15f64f6|imgt:hasClinicalIndication|imgt:Immune_thrombocytopenia_(ITP) imgt:10315|rdfs:label|10315 imgt:StudyProduct_8037ac88-b353-3582-afaf-b797db588a1b|imgt:hasClinicalPhase|imgt:Phase_I/II obo:NCIT_C95784|rdf:type|owl:Class imgt:F(ab%27)2-nd-nd_207|rdfs:comment|F(ab')2 - nd - nd imgt:Fab-G1-kappa_287|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/Fab-G1-kappa.png imgt:C5_(complement_5)_anaphylatoxin_(C5a,_C5_Pr678-751)|skos:definition|C5 (complement 5) anaphylatoxin (C5a, C5 Pr678-751) imgt:IgG1-kappa_422|http://semanticscience.org/resource/SIO_000291|imgt:IGHE imgt:Product_16aae7ef-cb35-3b16-8b5b-31224a407d63|imgt:isProductOf|imgt:mAb_702 imgt:Construct_1137|imgt:isConstructOf|imgt:IgG4-kappa_1137 imgt:mAb_923|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=923 imgt:Product_d7c83c7a-94a0-330e-98d7-6d98bcc47c31|imgt:isProductOf|imgt:mAb_340 imgt:Construct_1081|rdfs:label|Construct_1081 imgt:mAb_249|imgt:inn_name|denosumab imgt:Clone_38|imgt:isOriginCloneOf|imgt:mAb_38 imgt:IL31RA|imgt:isTargetOf|imgt:IgG2-kappa_538 _:B1210e9664b81d576423be0ec39f91950|imgt:hasDesignation|imgt:Orphan_drug imgt:Product_73e39efa-0896-3bae-99e0-f9cfef01166f|rdf:type|obo:NCIT_C51980 imgt:Segment_1213_1|rdfs:label|Segment_1213_1 imgt:IgM-nd_310|imgt:isMabReceptorOf|imgt:mAb_310 imgt:Product_df36c7dd-b2c5-31f0-8c96-9341a9d2efeb|imgt:hasStudyProduct|imgt:StudyProduct_3d121ca8-316d-3ca0-b2f7-e6bf6fd3dbc7 imgt:StudyProduct_14e61c20-cab3-33d1-a4bb-d83099d452ed|imgt:hasClinicalIndication|imgt:Pemphigus_vulgaris_(PV) imgt:IgG1-kappa_648|imgt:isMabReceptorOf|imgt:mAb_648 imgt:StudyProduct_58617ef2-e46f-39d3-ac02-35c77464c839|imgt:application_type|Therapeutic imgt:StudyProduct_da35b2ab-85c1-3f27-83f8-e101e879cce1|rdfs:label|StudyProduct_da35b2ab-85c1-3f27-83f8-e101e879cce1 imgt:Construct_685|obo:BFO_0000051|imgt:Segment_685_1 imgt:StudyProduct_49a6ecb0-696f-32af-84e6-e9658bf9999a|imgt:hasClinicalPhase|imgt:Phase_M imgt:StudyProduct_f27f0576-2955-3f34-b8f5-1c8f6feec033|imgt:isStudyProductOf|imgt:Product_6bc98c9a-0b0b-3b1e-a407-ec0e4a4c2c92 imgt:Fab-nd-nd_320|rdf:type|imgt:MAbReceptor imgt:CPCA_PROTEIN-PEG-FC_613|obo:RO_0002162|imgt:Homsap imgt:mAb_638|imgt:inn_name|interferon gamma imgt:Rheumatoid_arthritis_(RA)|imgt:isClinicalIndicationOf|imgt:StudyProduct_7f439e60-29e2-39db-a44a-9727a9db98cb imgt:mAb_125|imgt:imgt_note| mAb radiolabelled used in radio-immuno-scintigraphy The murine ImmuRAIT-LL2 was halted in favor of the humanized epratuzumab to obviate immunogenicity imgt:V-IOTA|rdf:type|imgt:V-DomainLabel imgt:Product_509a2852-44b3-30df-adde-48683fe9f2d4|imgt:isProductOf|imgt:mAb_41 imgt:Segment_161_1|imgt:has_rank|1 imgt:11532|rdf:type|obo:NCIT_C25402 imgt:ConfigurationType|owl:disjointWith|imgt:MolecularComponent imgt:Product_7a640788-9a95-363a-8d3a-541b7fcd35e8|imgt:hasStudyProduct|imgt:StudyProduct_61a5914e-5af5-35d9-96f6-491cc8d3f099 imgt:StudyProduct_7a967703-290b-3e04-89fc-4cd1051440a7|imgt:isStudyProductOf|imgt:Product_822d4860-e4cc-3044-94aa-7b43f22ba9d7 imgt:mAb_845|rdf:type|obo:NCIT_C137682 imgt:StudyProduct_50790561-55d2-36e3-8516-a31edc3dcfeb|imgt:hasExpressionSystem|imgt:_CHOK1SV_(expresses_glutamine_synthetase_(GS)_endogenously)_cells imgt:9537|imgt:isImgtStructureEntryOf|imgt:mAb_405 imgt:Product_540b3929-a375-3db7-8982-d2f9143d05ad|rdfs:label|Product_540b3929-a375-3db7-8982-d2f9143d05ad imgt:C-GAMMA-1|rdf:type|imgt:ChainLabels imgt:PharmAbcine_Inc|rdf:type|obo:NCIT_C54131 imgt:Construct_667|imgt:isConstructOf|imgt:IgG2-kappa_667 imgt:Product_ff7f8ab2-ffcc-3549-b91f-01ae4cd1fac6|imgt:commun_name|REGN-3470/REGN-3471/REGN-3479 imgt:IgG4-kappa_375|http://semanticscience.org/resource/SIO_000291|imgt:SOST imgt:Product_548e85bb-73f0-3eda-a78b-8134d0e04416|imgt:hasStudyProduct|imgt:StudyProduct_25d572e2-3633-3829-b477-3a66deb30420 imgt:StudyProduct_0c6fab37-a4a5-3c73-807f-26e4849bf093|imgt:hasClinicalIndication|imgt:Cancers_nasopharyngeal imgt:mAb_994|imgt:imgt_note| Ruf P. et al. Ganglioside GD2-specific trifunctional surrogate antibody Surek demonstrates therapeutic activity in a mouse melanoma model. J Translational Medicine 10, 219 (2012).https://translational-medicine.biomedcentral.com/articles/10.1186/1479-5876-10-219 \r Surek antibody (#994) is a surrogate of ektomab (#996), used in a mouse melanoma model. \r The targets of these bispecific antibodies are Homo sapiens GD2 ganglioside (cell surface antigen glycolipids, melanoma associated gangliosides GD2 as well as its precursor GD3) and CD3E (respectively, Mus musculus CD3E (#994) and Homo sapiens CD3E (#996)). imgt:StudyProduct_11ccf5f8-b5db-36fd-b9b4-9e072257a5f4|rdfs:label|StudyProduct_11ccf5f8-b5db-36fd-b9b4-9e072257a5f4 imgt:IgG1-lambda_262|imgt:isMabReceptorOf|imgt:mAb_262 imgt:IgG1-kappa-4lys-drug_600|rdf:type|imgt:MAbReceptor imgt:Product_4a797e84-8295-30a5-8686-ca6de1774780|imgt:isProducedBy|imgt:Facet_Biotech imgt:IgG1-kappa_255|http://semanticscience.org/resource/SIO_000291|imgt:AFP imgt:8887|rdf:type|obo:NCIT_C25402 imgt:StudyProduct_d3511696-fb40-3fd3-86b5-7762cd34d2b1|rdfs:label|StudyProduct_d3511696-fb40-3fd3-86b5-7762cd34d2b1 imgt:mAb_374|imgt:hasProduct|imgt:Product_e43a8019-eea8-307e-b67c-b0bd073d0380 imgt:Product_19be9437-f626-344b-9200-e7b704079fdb|imgt:commun_name|CD19-4-1BBL imgt:StudyProduct_20176e48-84e8-3a6b-b2b8-ab0c782c868a|imgt:application_type|Therapeutic imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_22103a77-55ac-3a6b-969c-686e568dfecb imgt:IgG4-kappa-lambda_973|imgt:hasMolecularComponent|imgt:IG imgt:Construct_80|rdfs:label|Construct_80 imgt:Product_4567b158-71e6-3aab-97f8-559512f41894|imgt:hasStudyProduct|imgt:StudyProduct_e60fb895-c627-39e6-a56f-3b0b545cbd12 imgt:StudyProduct_ffef88d6-739a-374e-828d-ad5eee20ab3e|imgt:hasClinicalIndication|imgt:Sporadic_inclusion_body_myositis_(sIBM) imgt:StudyProduct_0f7eb5d2-25f4-3ec3-903d-96073744e63d|imgt:hasClinicalIndication|imgt:Palmoplantar_pustulosis imgt:Product_cef966d9-7220-3c3b-8d4c-3695c4e55488|rdf:type|obo:NCIT_C51980 _:B7fbff108376d32b20983db1b13df9a1e|dc:date|2016-02-10 imgt:STAB1|rdfs:label|STAB1 imgt:StudyProduct_a4579212-c26a-3666-8b80-15da493b5d2b|imgt:hasClinicalIndication|imgt:Chronic_lymphocytic_leukemia_(CLL) imgt:Construct_501|imgt:isConstructOf|imgt:IgG1-kappa_501 imgt:hasDesignation|rdfs:label|hasDesignation imgt:mAb_567|imgt:hasProduct|imgt:Product_dfe835ee-5c5b-301c-9664-637ed6a8128c imgt:Product_15a67350-7e03-3a46-9478-b8533a0c6d6a|imgt:isProducedBy|imgt:Roche_F_Hoffmann-La_Roche_Ltd imgt:Segment_522_1|obo:BFO_0000050|imgt:Construct_522 imgt:Construct_943|imgt:isConstructOf|imgt:IgG1-lambda_943 imgt:Product_23bdc528-2f16-3a86-9e4c-0033da4742f2|rdfs:label|Product_23bdc528-2f16-3a86-9e4c-0033da4742f2 imgt:mAb_653|imgt:inn_proposed_list|115 (2016) imgt:Refractory_B-lineage_non-Hodgkin_lymphoma|rdfs:label|Refractory_B-lineage_non-Hodgkin_lymphoma imgt:Product_e82ab2c8-921c-3025-bab2-62336472f64d|imgt:hasStudyProduct|imgt:StudyProduct_ff02fdb0-13d8-318a-af5f-902f811d122b imgt:Product_616f015a-2ec9-334a-933d-d673091d2b9e|rdfs:label|Product_616f015a-2ec9-334a-933d-d673091d2b9e imgt:Product_dfc4f177-ae40-3384-9acd-82ec2294cba6|imgt:isProducedBy|imgt:Shanghai_Junshi_Biosciences_Co_Ltd imgt:Construct_605|imgt:isConstructOf|imgt:IgG1-kappa_605 imgt:IgG2-kappa_929|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG2-kappa.png imgt:EX4UTR|skos:definition|untranslated EX4 with 3'UTR of TR alpha or TR delta C-GENE, in gDNA or in cDNA imgt:StudyProduct_977172bc-a3d4-34c3-95d9-591ceea2178a|rdf:type|obo:NCIT_C174271 _:B7dc15e7181cfada9cd71f017c16f7c3d|dc:date|2018-08-16 imgt:mAb_584|imgt:hasMabReceptor|imgt:IgG1-kappa_584 obo:NCIT_C184936|rdf:type|owl:Class obo:NCIT_C38697|rdf:type|owl:Class imgt:FPIA_%5BPROTEIN_1DOMAIN_1CLIKE-PROTEIN_5DOMAINS_5F%5D2-FC_730|imgt:isMabReceptorOf|imgt:mAb_730 imgt:mAb_761|imgt:hasMabReceptor|imgt:IgG1-kappa_761 imgt:mAb_886|imgt:inn_proposed_list|120 (2018) imgt:Clone_1003|rdf:type|obo:NCIT_C37925 imgt:Segment_951_1|imgt:has_rank|1 imgt:Cancers_non-small_cell_lung_(NSCLC)|imgt:isClinicalIndicationOf|imgt:StudyProduct_5b4aa7bc-b75e-3c8f-ba79-dfaf86f501a9 imgt:StudyProduct_ae9eb8ad-e43a-358b-b30c-6a6b816d5366|rdf:type|obo:NCIT_C174271 pubmed:21170091|imgt:isBibliographicReferenceOf|imgt:mAb_11 imgt:EGFR_(Pr28-459)|skos:definition|EGFR protein imgt:mAb_1068|imgt:hasImgtStructureEntry|imgt:11390 imgt:StudyProduct_319335a0-2bef-3d34-bb33-1ba138c412f9|rdfs:label|StudyProduct_319335a0-2bef-3d34-bb33-1ba138c412f9 imgt:F(ab’)2-Gamma-3_Lambda|rdfs:label|F(ab’)2-Gamma-3_Lambda imgt:StudyProduct_77048b76-4d88-3f02-aef9-5d02df47e969|rdf:type|obo:NCIT_C174271 imgt:Product_a8e7144e-8be0-3481-a89b-994c08a8e5d0|rdf:type|obo:NCIT_C51980 imgt:RPILabel|skos:definition|Related proteins of the immune system imgt:IG-Heavy-Alpha-1-IGHA1|rdfs:label|IG-Heavy-Alpha-1-IGHA1 imgt:IgG2-lambda_492|imgt:hasConstruct|imgt:Construct_492 imgt:StudyProduct_f8e070f0-9178-373d-9d81-ffb46c539e03|imgt:hasClinicalPhase|imgt:Phase_M imgt:Product_f54c6043-6277-3c37-b202-92f1deb4aaff|imgt:comercial_name|RoACTEMRA® imgt:EPOR|imgt:isTargetOf|imgt:PROTEIN_1DOMAIN-PEG_681 imgt:ScFv-Gamma-Delta|imgt:isDefinedBy|imgt:ScFv-Gamma-Delta imgt:StudyProduct_f0431bbe-f9ca-3eba-a26f-88d04c64aaaf|imgt:hasDecision|_:Bc0c13bd529ea24702d9a75607bf1b749 imgt:mAb_879|imgt:hasMabReceptor|imgt:IgG1-kappa-2cys-CH3_879 imgt:Condylomata_acuminata_(anogenital_warts)|rdf:type|obo:NCIT_C185637 imgt:Construct_1130|imgt:isConstructOf|imgt:IgG1-kappa_1130 imgt:Bos_taurus_FSH_(follicle-stimulating_hormone)-CTP_(C-terminal_peptide_of_the_β-subunit_of_human_chorionic_gonadotropin_(hCG))|rdfs:label|Bos taurus FSH (follicle-stimulating hormone) - CTP (C-terminal peptide of the β-subunit of human chorionic gonadotropin (hCG)) imgt:StudyProduct_b70513a8-0baa-3a75-ab83-97c07e45443a|rdfs:label|StudyProduct_b70513a8-0baa-3a75-ab83-97c07e45443a imgt:Product_140c503b-9c60-33d9-ade4-ebf498c21611|rdf:type|obo:NCIT_C51980 imgt:Selexys_Pharmaceuticals|rdfs:comment|Oklahoma City , USA imgt:Clone_1245|rdf:type|obo:NCIT_C37925 imgt:Product_a23573c5-b373-324a-9d04-0e37a2bcdfa0|imgt:hasStudyProduct|imgt:StudyProduct_5da6fd02-f1ce-3846-9ec8-808684e1ead5 imgt:Fab-Gamma-1_Kappa|imgt:isDefinedBy|imgt:IG-Light-Kappa-IGKC imgt:Product_94d8dc7c-0c7e-33a1-a27f-260b76dbf359|imgt:isProducedBy|imgt:UCB imgt:Non-Hodgkin's_lymphoma_(NHL)|imgt:isClinicalIndicationOf|imgt:StudyProduct_0bed0fbb-df2b-3c03-97cf-ee0147aea3a7 imgt:mAb_1054|rdf:type|imgt:INN imgt:IgG1-kappa_1146|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:hasDomainType|rdfs:label|hasDomainType imgt:mAb_1262|imgt:inn_number|11914 imgt:mAb_838|imgt:inn_proposed_list|123 (2020) imgt:polymeric_immunoglobulin_receptor|dc:identifier|imgt_000296 imgt:Clone_942|imgt:clone_name|UCB3-CB-CC2-TR1-MP83-C64 imgt:V-kappa|rdf:type|imgt:SegmentLabels _:B2bc968753dc66c25747bd0e4ef1b78ce|imgt:isDecisionOf|imgt:StudyProduct_4959e9db-1cfb-3ac4-8852-88fe6ff01da0 imgt:StudyProduct_cb0b14d5-e566-3f31-a036-de951237d151|rdfs:label|StudyProduct_cb0b14d5-e566-3f31-a036-de951237d151 imgt:Product_456d564b-7ac0-3592-8ca9-cd2dfb44a72d|imgt:commun_name|MEDI2452, anti-ticagrelor, antidote for ticagrelor imgt:Product_b0125efb-d294-356b-81c9-df23c973888d|imgt:hasStudyProduct|imgt:StudyProduct_5a1d70be-9799-3766-a0cf-3fcdf0fffb95 imgt:StudyProduct_40e1a270-5276-3064-a146-8993d30876bc|imgt:hasClinicalPhase|imgt:Phase_M imgt:Product_79d778e7-a268-3986-be2c-1751015d118f|imgt:commun_name|MEDI3902 imgt:mAb_1147|imgt:inn_number|11655 imgt:IgG1-kappa_411|rdfs:label|IgG1-kappa_411 imgt:StudyProduct_e3c462d1-71b2-3c90-b773-e7ac07667f21|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells 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imgt:StudyProduct_325e5cda-6137-3a4e-80fe-43c7609968e4|imgt:hasClinicalIndication|imgt:Lymphoma_diffuse_large_B_cell_(DLBCL) imgt:mAb_268|rdf:type|imgt:INN imgt:10770|rdfs:label|10770 imgt:Clone_223|rdf:type|obo:NCIT_C37925 imgt:Product_56576134-cfbd-35a6-b65a-05844543f13f|imgt:commun_name|CDP 6038 imgt:11710|imgt:isImgtStructureEntryOf|imgt:mAb_1179 imgt:mAb_118|rdf:type|imgt:INN imgt:IgE_Kappa|rdf:type|imgt:ReceptorType imgt:mAb_937|rdf:type|imgt:INN imgt:Product_1359517a-169f-37c5-bcf3-e739b8e3653d|imgt:isProductOf|imgt:mAb_797 imgt:StudyProduct_dc72fa34-486c-3e9d-a321-65ce6cbb02ef|rdf:type|obo:NCIT_C174271 imgt:Segment_678_1|rdf:type|imgt:Segment imgt:Product_d0b4ae6d-7aac-3e07-ba48-06ade646cf35|imgt:commun_name|IL2 fused to diphteria toxin imgt:Product_3d3847b0-2ca8-3154-aa57-18221948bd0d|rdf:type|obo:NCIT_C51980 imgt:Duchenne_muscular_dystrophy_(DMD)|imgt:isClinicalIndicationOf|imgt:StudyProduct_dae5d81d-0d3a-3559-9a25-4829888c5e83 imgt:StudyProduct_53183842-71ef-3bbc-a045-3c4e63aa385f|imgt:hasClinicalIndication|imgt:Acute_myocardial_infarction imgt:Osteoporosis_men|imgt:clinical_domain|Osteology imgt:Product_987c1b09-a20e-3038-98db-246a99be8e1c|imgt:commun_name|BAY2635190 imgt:StudyProduct_edba8cce-ecf8-362b-a1ac-f7546216939e|imgt:hasClinicalIndication|imgt:Renal_cell_carcinoma_(RCC) imgt:StudyProduct_5a0cba82-db5d-38b2-aa35-2dd98c602d95|imgt:isStudyProductOf|imgt:Product_d2501478-25a5-378b-ae83-ee188222f233 imgt:IgG1-kappa_927|obo:RO_0002162|imgt:Homsap imgt:Diffuse_scleroderma|imgt:isClinicalIndicationOf|imgt:StudyProduct_823b3fc8-8498-335e-a480-720d21c78305 imgt:_Sp2/0-Ag14_mouse_hybridoma_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_3b978335-3ad0-3d4d-be6b-4bd94a891758 _:Ba5a12cb103757e091531982f7bfa1442|dc:date|2011-03-10 imgt:Product_a485a257-0ee7-3b5b-836e-05670bd746d8|imgt:commun_name|RO7030816 _:B72c9affccd5d6107a87ce96c04826a8f|dc:date|1999-02-01 imgt:StudyProduct_c7bbb604-7c1c-3680-8247-0c272db49a47|imgt:hasClinicalPhase|imgt:Discontinued imgt:Product_62e555bc-de18-34ed-b8f6-f3695acdd1ce|imgt:commun_name|AGS-22M6E imgt:Product_f6c7a871-ae54-30b2-abf8-50b6400072df|rdfs:label|Product_f6c7a871-ae54-30b2-abf8-50b6400072df imgt:Product_d543ad3f-1804-3da5-9df5-22b5b9b66bdf|rdf:type|obo:NCIT_C51980 imgt:Neoplasms|imgt:isClinicalIndicationOf|imgt:StudyProduct_b9be3f79-4f01-31aa-84b7-f5009068f66f imgt:Fab-nd-nd|rdf:type|imgt:ConstructLabels imgt:StudyProduct_b9617fc0-a404-3cff-ac56-94d20bcda253|imgt:hasClinicalPhase|imgt:Phase_II imgt:StudyProduct_51a3d172-4b1c-3c0f-90ba-b58f089b413e|imgt:hasClinicalIndication|imgt:Lupus_nephritis imgt:StudyProduct_e5f0beb1-a80e-36e6-a4a0-070f7557869a|imgt:development_technology| YB2/0 cell line: low fucosylation imgt:PROTEIN_2DOMAINS_933|rdf:type|imgt:MAbReceptor imgt:CD19|imgt:isTargetOf|imgt:scFv-heavy-kappa-CD28_(CO-TM-CY)-CD247_876 imgt:StudyProduct_b77efce1-2390-394a-ae98-f0fc7433860c|rdf:type|obo:NCIT_C174271 imgt:Lymphoma_splenic_marginal_zone_(SMZL)|imgt:isClinicalIndicationOf|imgt:StudyProduct_5335348c-cd60-3fb3-a01c-4588efc82101 imgt:Construct_627|rdf:type|imgt:Construct imgt:mAb_380|rdf:type|imgt:INN imgt:Thrombocytopenia|imgt:clinical_domain|Hematology imgt:Renal_cell_carcinoma_(RCC)|imgt:isClinicalIndicationOf|imgt:StudyProduct_d24549d2-16af-3305-88f2-6445585bd19e imgt:Segment_879_1|imgt:has_rank|1 imgt:StudyProduct_9356e1ff-b86a-345b-99f2-b7aeb630222c|rdf:type|obo:NCIT_C174271 imgt:Product_11b9842e-0a27-3ff2-92c1-903e7132cd68|rdfs:label|Product_11b9842e-0a27-3ff2-92c1-903e7132cd68 imgt:StudyProduct_69ef2360-5f7b-3ffe-915d-120181a43118|imgt:hasClinicalIndication|imgt:Cancers_breast imgt:mAb_160|imgt:hasOriginClone|imgt:Clone_160 imgt:Product_4567b158-71e6-3aab-97f8-559512f41894|imgt:commun_name|MAGE-A10-c796T imgt:Product_9215dd29-19a5-360f-9f0c-c9c5d5534fe4|imgt:hasStudyProduct|imgt:StudyProduct_9215dd29-19a5-360f-9f0c-c9c5d5534fe4 imgt:Product_548e85bb-73f0-3eda-a78b-8134d0e04416|rdfs:label|Product_548e85bb-73f0-3eda-a78b-8134d0e04416 imgt:Segment_1064_1|imgt:hasImgtLabel|imgt:IgG2-kappa imgt:Product_60a7e5e0-2e5d-36e9-bbf7-3aa985aa9408|rdf:type|obo:NCIT_C51980 imgt:mAb_46|imgt:hasImgtStructureEntry|imgt:2FGW imgt:Product_f1ec19af-7de9-3338-a0c4-5659cd375377|imgt:commun_name|hPAM4 imgt:StudyProduct_856c5397-7756-3d89-9380-256a0d6c6b0f|imgt:hasClinicalPhase|imgt:Phase_III pubmed:8097341|rdf:type|bibo:Article imgt:Product_5ce3b46d-9c42-34a1-a25d-2571a2d48a7a|imgt:commun_name|MTIG7192A imgt:Product_e8799a18-910d-3034-89ea-23f84f7fa73f|rdfs:label|Product_e8799a18-910d-3034-89ea-23f84f7fa73f imgt:Product_d4a38f5a-7adc-3e81-9fb9-4d3d7818a952|imgt:commun_name|HTI-1088 imgt:StudyProduct_fa9e9335-1b3f-3e3a-a607-ab3d3d1b6e2a|imgt:hasClinicalIndication|imgt:Hodgkin_lymphoma imgt:9415|rdf:type|obo:NCIT_C25402 imgt:Product_20b6d3b5-9b57-3faf-8a71-7c264afd5776|rdf:type|obo:NCIT_C51980 imgt:Product_a142a049-54e9-384c-a505-7346d9abf873|imgt:isProductOf|imgt:mAb_474 imgt:IG-GAMMA-4_KAPPA|rdfs:label|IG-GAMMA-4_KAPPA imgt:Regeneron_Pharmaceuticals_Inc|imgt:produces|imgt:Product_4dfdcc11-43d7-3ba0-8c58-bfd2cd24ea95 imgt:mAb_444|rdfs:label|mAb_444 imgt:11958|rdf:type|obo:NCIT_C25402 _:Bf067e2db5b030a4e570331a107ec2108|imgt:hasStatut|imgt:withdrawal imgt:SplicingSiteLabel|rdfs:subClassOf|imgt:SequenceLabels imgt:mAb_161|imgt:hasImgtStructureEntry|imgt:7609 _:B8611164b7e4e98463264a4bc1c00e297|imgt:hasDesignation|imgt:Orphan_drug imgt:IgG1-kappa_1110|rdfs:comment|IgG1 - kappa imgt:Product_2a3ef47f-5316-35ed-88d8-4e4553dda6a6|rdf:type|obo:NCIT_C51980 imgt:HCV|rdf:type|obo:NCIT_C25702 imgt:StudyProduct_ec3e69b2-60fd-38b8-824f-479713d10289|imgt:hasDecision|_:B8def487a870b2cd5fdae3a4b6c489f70 imgt:MH1LIKE-ALPHA-LIKE%5B3D%5D|skos:definition|MH receptor comprising one I-ALPHA-LIKE chain imgt:Product_a190dd19-75e1-3b82-8ca6-7b52a624f875|imgt:hasStudyProduct|imgt:StudyProduct_14827a6a-a4ac-3723-b51f-22dea68d060e imgt:GDF11|skos:definition|GDF11 (growth differentiation factor 11, BMP-11) imgt:mAb_65|imgt:inn_recommended_list|58 (2007) _:Bc6d33d3255c332dd6ecc193d5c85034b|imgt:hasStatut|imgt:approval _:B6286cc1877cabecf761763bccd122d0a|rdf:type|obo:NCIT_C53285 imgt:StudyProduct_41f605ec-a051-3012-8f57-0128f8602937|imgt:hasClinicalIndication|imgt:Lymphoma_follicular_(FL) imgt:AstraZeneca|imgt:produces|imgt:Product_1f864c32-9353-3a93-8c8b-c41e0f2b9f98 imgt:SOST|imgt:isTargetOf|imgt:IgG2-kappa_404 imgt:ACVR2B_(Pr20-134)|rdf:type|imgt:DomainLabel imgt:StudyProduct_71b75379-eb4c-3f15-b0fc-beda141a12a8|imgt:hasClinicalIndication|imgt:Cancers imgt:mAb_1255|imgt:hasOriginClone|imgt:Clone_1255 imgt:Product_2136ea09-1f27-3c33-93cc-520404243949|imgt:hasStudyProduct|imgt:StudyProduct_30e7b18e-ba8f-3e71-90a6-671525dbbf3b imgt:mAb_569|imgt:inn_recommended_list|75 (2016) imgt:StudyProduct_f433b026-1e29-33a9-9131-6f46a3a38d76|imgt:application_type|Therapeutic imgt:_(CHO)-derived_cell_line_transfected_with_the_glutamine_synthetase_(GS)|rdfs:label| (CHO)-derived cell line transfected with the glutamine synthetase (GS) imgt:Product_e975b070-9be2-38ce-bb6e-ecee5129340b|imgt:isProducedBy|imgt:PhaseBio imgt:IgG1-nd_276|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-nd.png imgt:IgG1-kappa_788|http://semanticscience.org/resource/SIO_000291|imgt:TNF imgt:Allergic_rhinitis|imgt:clinical_domain|Immunology imgt:scFv-heavy-kappa_173|http://semanticscience.org/resource/SIO_000291|imgt:heat_shock_protein_90_homolog imgt:10945|rdf:type|obo:NCIT_C25402 imgt:IGF1|obo:RO_0002162|imgt:Homsap imgt:HOR-CTP_696|rdfs:comment|HOR-CTP imgt:IgG4-kappa_1187|obo:RO_0002162|imgt:Hum imgt:10365|rdf:type|obo:NCIT_C25402 imgt:Product_5a522bda-223b-3b4e-80fb-796b1b9ea3b5|imgt:hasStudyProduct|imgt:StudyProduct_17fffcc0-45dc-3607-ba3a-7a9c5ec0a221 imgt:mAb_216|imgt:inn_proposed_list|81 (1999) imgt:IgG4-kappa-%5BscFv%5D2_776|http://semanticscience.org/resource/SIO_000291|imgt:bispecific imgt:mAb_1099|imgt:inn_proposed_list|123 (2020) imgt:Product_77943964-50dd-359e-ba7c-5a01caa40e25|rdfs:label|Product_77943964-50dd-359e-ba7c-5a01caa40e25 imgt:Product_419876d7-c157-30b2-b42a-6232519b26b0|imgt:hasStudyProduct|imgt:StudyProduct_dae5d81d-0d3a-3559-9a25-4829888c5e83 imgt:StudyProduct_b97ea00c-a193-3e97-b1e7-738ccbd8aa85|imgt:application_type|Therapeutic imgt:mAb_354|imgt:imgt_note| oxelumab CAS number is the one amended in L105 (2011). 30 June 2011 - Discontinued - Phase II for Allergic asthma in Canada (IV), Phase I for allergic rhinitis in USA (IV). _:Bb49def70af2d032a6ee6c4df01399b49|rdf:type|obo:NCIT_C53285 imgt:StudyProduct_570b0f62-6343-325d-9344-8d8294daefd4|rdf:type|obo:NCIT_C174271 imgt:Construct_696|obo:BFO_0000051|imgt:Segment_696_2 imgt:Segment_673_3|imgt:has_rank|3 imgt:Construct_765|obo:BFO_0000051|imgt:Segment_765_1 imgt:Construct_142|imgt:isConstructOf|imgt:IgG2a-lambda_142 imgt:IgE_mediated_allergies|imgt:clinical_domain|Immunology obo:NCIT_C1569|rdfs:subClassOf|obo:NCIT_C1909 imgt:IgG4-kappa_1203|imgt:hasMolecularComponent|imgt:IG imgt:mAb_102|rdf:type|imgt:INN imgt:VH-VH_401|obo:RO_0002162|imgt:Hum imgt:Clone_181|obo:RO_0002162|imgt:Homsap imgt:Segment_245_1|obo:BFO_0000050|imgt:Construct_245 imgt:Product_30743126-1663-3efd-94f6-fc3d52aec2a9|rdfs:label|Product_30743126-1663-3efd-94f6-fc3d52aec2a9 imgt:%5BCA_exendin-4-PEG_linker_%5D1-IGHG4_Fc_(Fragment_constant)|imgt:construction_detail|Conjugate - [CA exendin-4 - PEG linker ]1 - IGHG4 Fc (Fragment constant) imgt:Aravive_Biologics_Inc|imgt:produces|imgt:Product_8ab7fc81-b8d6-308e-9064-5a153be43d1b imgt:10506|imgt:isImgtStructureEntryOf|imgt:mAb_640 imgt:mAb_482|imgt:hasProduct|imgt:Product_649c78e1-1746-3b13-9ec9-5bd0cc1a8e70 imgt:IgG1-nd_26|http://semanticscience.org/resource/SIO_000291|imgt:MUC1 imgt:mAb_244|rdfs:label|mAb_244 imgt:FAB-EPSILON_LAMBDA|imgt:describes|imgt:Fab-Epsilon_Lambda imgt:StudyProduct_ded10426-11bf-3f46-bb52-46aae2cecf95|imgt:application_type|Therapeutic imgt:Construct_1|obo:BFO_0000051|imgt:Segment_1_1 imgt:Product_f04cdfd4-6994-39a9-83ff-19d51122d4c0|imgt:commun_name|14F7 imgt:Segment_1259_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:mAb_1151|imgt:hasImgtStructureEntry|imgt:11549 _:Be09485c99ed6c8e237e3695b04c7ed7f|rdf:type|obo:NCIT_C53285 imgt:FAB-GAMMA-4_LAMBDA|rdf:type|imgt:StructureLabels imgt:MAbReceptor_833|rdf:type|imgt:MAbReceptor imgt:Segment_1233_1|imgt:has_rank|1 imgt:Fab-Gamma-4_Kappa|imgt:isDefinedBy|imgt:IG-Heavy-Gamma-4-IGHG4 imgt:10681|rdf:type|obo:NCIT_C25402 imgt:StudyProduct_5f24239e-1e10-32d1-8b60-8abd532e4dd8|imgt:hasDecision|_:B54ba76f45c209d42e8ee61bc84aaa3b1 imgt:StudyProduct_10fe858f-824f-3374-b210-1fe3fe64531d|rdfs:label|StudyProduct_10fe858f-824f-3374-b210-1fe3fe64531d imgt:9933|rdfs:label|9933 imgt:CH5|rdfs:label|CH5 imgt:StudyProduct_3bfb5bc3-c14e-31cc-9d99-7b4c77373aa4|rdf:type|obo:NCIT_C174271 _:B1d7f6f642293fe374dbf3064f3137d51|imgt:isDecisionOf|imgt:StudyProduct_a4579212-c26a-3666-8b80-15da493b5d2b imgt:mAb_99|imgt:imgt_note| VH and V-KAPPA domain sequences of 4D5-8 (trastuzumab, anti-ERBB2) are from Carter PL et al. Proc. Natl. Acad. Sci. USA 89(10):4285-9 (1992). PMID: 1350088 VH and V-KAPPA domain sequences of humanized UCHT1-v1 (anti-CD3E) are from Shalaby MR et al. J. Exp. Med; 175:217-225 (1992) PMID: 1346155 The two Fab’ are chemically linked as described in Shalaby MR et al. (1992) (directed chemical coupling of the Fab’-thionitrobenzoate derivative (Fab’-TNB) of UCHT1-v1 with the Fab’-SH of 4D5-8). Method for making humanized antibodies: WO 1992022653 A1 , Carter PJ and Presta LG (1992). imgt:N2-REGION|skos:definition|coding region of the IG or TR V-DOMAIN N region 2, in rearranged gDNA or cDNA imgt:_BHK_cells_(ATCC_CCL_10)|imgt:isExpressionSystemOf|imgt:StudyProduct_0f54f11d-72e5-3cd1-a127-6ddf3cf72382 imgt:Autoimmune_diseases_CD4_mediated|imgt:clinical_domain|Immunology imgt:mAb_1024|imgt:hasMabReceptor|imgt:IgG1-kappa_1024 imgt:StudyProduct_30d64f00-34cf-3fd4-ab13-6ba911ba69eb|rdfs:label|StudyProduct_30d64f00-34cf-3fd4-ab13-6ba911ba69eb imgt:StudyProduct_33876951-f246-3ad5-89f6-0a4499572f85|imgt:development_technology| Dyax human antibody phage display library imgt:mAb_264|imgt:inn_number|8412 _:B3ec5340dfe66cfdc4aec1d3b5cbb4c02|imgt:hasDesignation|imgt:Orphan_drug imgt:mAb_1251|imgt:inn_number|12050 imgt:IgG1-kappa_1145|imgt:hasConstruct|imgt:Construct_1145 imgt:scFv-kappa-heavy-CD3E_(CO-TM-CY)_1300|http://semanticscience.org/resource/SIO_000291|imgt:CD19 imgt:mAb_457|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=457 imgt:11417|rdf:type|obo:NCIT_C25402 imgt:StudyProduct_6974cbb5-2147-37d3-b512-1d3f6aa12a09|imgt:development_technology| DuoBody® imgt:IgG1-lambda_456|imgt:hasConstruct|imgt:Construct_456 imgt:mAb_640|imgt:inn_recommended_list|78 (2017) imgt:VARIATION|rdfs:label|VARIATION imgt:StudyProduct_9fb25145-bfe7-33f6-9117-a8a9ca677ff6|imgt:hasClinicalPhase|imgt:Phase_I imgt:StudyProduct_a3aa9a89-b162-305d-b9cf-f56e5aee9631|imgt:hasClinicalIndication|imgt:Mastocytosis imgt:Product_d48dfd80-b563-3b2c-bc14-3f6855226bd6|imgt:hasStudyProduct|imgt:StudyProduct_db4bfc49-83fe-3bee-9399-bebbe1e1a6e9 imgt:Product_b12ab81c-147d-34f3-aa01-f95e94eb88de|imgt:hasStudyProduct|imgt:StudyProduct_a5c2aaa4-63b6-39e7-9d9b-914f019f8060 imgt:Product_67e444bf-348a-3c05-b092-025f7e9ae4b8|rdf:type|obo:NCIT_C51980 imgt:Construct_549|obo:BFO_0000051|imgt:Segment_549_1 imgt:Product_37063952-98fd-3fe4-9109-09b267840368|imgt:commun_name|MG-A271 imgt:StudyProduct_0e54bccd-7463-3c62-b3aa-f7ef86c2fb45|rdf:type|obo:NCIT_C174271 imgt:Medarex|imgt:produces|imgt:Product_eee3061f-bf14-3e3d-9646-c7c2fe6d3166 imgt:IGHG4|rdfs:label|IGHG4 _:Bca1e18b35e9fcc5d12e998a15776e61e|imgt:isDecisionOf|imgt:StudyProduct_e2e85e71-8474-3ca4-819d-c7d2a030d59b imgt:%5BSELPLG_(selectin_P_ligand_selectin_P_glycoprotein_ligand_PSGL-1_CD162)_42-89%5D2-IGHG1_Fc_(Fragment_constant)|imgt:construction_detail|Fusion - [SELPLG (selectin P ligand, selectin P glycoprotein ligand, PSGL-1, CD162) 42-89]2 - IGHG1 Fc (Fragment constant) imgt:PROTEIN_2ANDHALFREPEATS-PEG_275|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/PROTEIN_2ANDHALFREPEATS-PEG.png imgt:CD74|rdfs:label|CD74 imgt:TOXIN_BIG-PEPTIDE_525|imgt:isMabReceptorOf|imgt:mAb_525 imgt:Ig(G1-kappa_G1-lambda)|rdf:type|imgt:ConstructLabels obo:NCIT_C170057|rdf:type|owl:Class 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imgt:mAb_122|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=122 imgt:Product_3fa823ee-5424-3729-b15a-e24345c3efb9|imgt:isProducedBy|imgt:Merrimack_Pharmaceuticals imgt:MAbReceptor_63|http://semanticscience.org/resource/SIO_000291|imgt:ITGB2 imgt:FST|rdf:type|imgt:SegmentLabels imgt:TNFRSF10B|imgt:isTargetOf|imgt:IgG1-kappa_234 imgt:MUC1_sialylated_carbohydrate_tumour-associated|rdf:type|obo:NCIT_C25702 imgt:mAb_230|imgt:hasImgtStructureEntry|imgt:8941 imgt:StudyProduct_99e9dc7c-7bd4-3b09-9fe5-56caee4039e2|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:mAb_227|imgt:hasProduct|imgt:Product_de55f944-c0ad-36b4-93fa-83f1570fb84b _:B1710fb856fbc319d2f26302e5c7f45b2|dc:date|2014-07-02 imgt:Fab%27-G1-kappa_596|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/Fab'-G1-kappa.png imgt:Clone_75|imgt:clone_name|AN100226m, MAb 21.6 _:Bafb0b015d0ec0e82b3a08dd76968924a|imgt:isDecisionOf|imgt:StudyProduct_3ade6364-93b7-321a-9b05-11dd7e21958f imgt:StudyProduct_41af9dec-ec77-305d-a3ef-c2f64f4a8ae7|imgt:hasClinicalIndication|imgt:T_cell_lymphoma _:Bbfaf935c5dad430745a247e482738450|dc:date|2016-07-27 imgt:StudyProduct_5a5c7b16-1104-3817-8817-64e9caa4b33b|rdf:type|obo:NCIT_C174271 imgt:fusion|rdfs:label|fusion imgt:mAb_452|imgt:hasMabReceptor|imgt:IgG1-kappa_452 imgt:MAbReceptor_994|rdfs:label|MAbReceptor_994 imgt:Segment_523_1|rdfs:label|Segment_523_1 imgt:Construct_363|rdfs:label|Construct_363 imgt:mAb_841|imgt:hasProduct|imgt:Product_4476af3b-5954-3f8e-a775-c9fd96f4dd5e imgt:Segment_753_1|imgt:has_rank|1 imgt:StudyProduct_08c22142-db46-3298-b221-05fa460a0128|imgt:hasClinicalPhase|imgt:Phase_I/II imgt:Fibrotic_diseases|imgt:clinical_domain|Dermatology imgt:Solid_tumors|imgt:isClinicalIndicationOf|imgt:StudyProduct_0a7ee814-2505-3fad-b45d-eb973c69a29d imgt:mAb_466|imgt:inn_number|9759 imgt:mAb_868|imgt:hasImgtStructureEntry|imgt:10759 imgt:IgG4-nd_614|http://semanticscience.org/resource/SIO_000291|imgt:CD274 imgt:StudyProduct_7c3ef30a-9ded-3a0d-a265-52ddf17bf64a|imgt:application_type|Therapeutic imgt:StudyProduct_e1e524e5-2856-31ae-a04d-78a07a803990|rdf:type|obo:NCIT_C174271 imgt:Construct_33|obo:BFO_0000051|imgt:Segment_33_1 imgt:mAb_679|rdf:type|obo:NCIT_C117238 imgt:mAb_350|imgt:inn_number|9309 imgt:IFNA2_(interferon_alpha_2)_*a_(K56_H57)_ 24-188|rdfs:label|IFNA2 (interferon alpha 2) *a (K56,H57)  24-188 imgt:Product_5afec3ec-290b-336b-a08f-33a38d788b45|rdf:type|obo:NCIT_C51980 imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_731650cb-173c-3766-9a69-c1690558868d imgt:Segment_1257_1|imgt:hasImgtLabel|imgt:IgM-kappa imgt:F(ab%27)2-G1-nd_134|rdfs:label|F(ab')2-G1-nd_134 imgt:Construct_862|imgt:hasImgtLabel|imgt:IgG4-kappa pubmed:9265500|dc:contributor|Léger OJ imgt:IgG1-lambda_909|imgt:hasConstruct|imgt:Construct_909 imgt:Construct_277|imgt:hasImgtLabel|imgt:IgG2-kappa imgt:Product_a92db19e-acaf-3b18-8363-ab3546fcfaa5|imgt:commun_name|CTI1601 imgt:exendin-4_(a_39_amino_acid_GLP1_mimetic)-XTEN|imgt:construction_detail|Fusion - exendin-4 (a 39 amino acid GLP1 mimetic) - XTEN imgt:CPCA_%5BPROTEIN_BIG%5D2-FC_395|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/CPCA_[PROTEIN_BIG]2-FC.png imgt:StudyProduct_ce81d579-19b4-39f9-ad98-bc8de370399e|imgt:isStudyProductOf|imgt:Product_8d65a859-3857-3302-b653-4bc73c441ecb imgt:Systemic_lupus_erythematosus_(SLE)|imgt:isClinicalIndicationOf|imgt:StudyProduct_4cd327d5-becb-33b0-9063-1b4d45383724 imgt:11078|rdf:type|obo:NCIT_C25402 imgt:IgG1-kappa_MM_115|rdfs:comment|IgG1-kappa_MM imgt:StudyProduct_a209289d-05ee-34a5-9eef-2f615f32282f|rdfs:label|StudyProduct_a209289d-05ee-34a5-9eef-2f615f32282f imgt:Segment_1122_1|rdfs:label|Segment_1122_1 imgt:mAb_296|imgt:hasMabReceptor|imgt:IgG1-kappa_296 obo:NCIT_C174714|rdfs:subClassOf|obo:NCIT_C1909 imgt:StudyProduct_5ad71dc8-9728-3c41-aef5-1290aea0238f|imgt:application_type|Therapeutic imgt:StudyProduct_7156d7b7-9362-3243-8e03-7b29b817b041|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_8fcafee5-f3c4-3bc8-be0c-c12970594487|imgt:hasClinicalIndication|imgt:Sarcoma imgt:StudyProduct_4585a5fe-30e1-3f1a-b4e6-d891c9afd909|imgt:hasClinicalPhase|imgt:Phase_II imgt:StudyProduct_50e27e1f-c4ca-30c3-829c-f5be1400c86f|imgt:isStudyProductOf|imgt:Product_2b19c2f5-d596-3bcf-8b1b-86730cfcfc4b imgt:mAb_575|imgt:hasImgtStructureEntry|imgt:10176 imgt:Segment_1062_1|rdfs:label|Segment_1062_1 imgt:Segment_744_2|obo:BFO_0000050|imgt:Construct_744 imgt:Atridia_Pty_Ltd|imgt:produces|imgt:Product_d897727a-4fb2-3eb1-99b5-48e3b1af7b74 imgt:StudyProduct_b77efce1-2390-394a-ae98-f0fc7433860c|rdfs:label|StudyProduct_b77efce1-2390-394a-ae98-f0fc7433860c imgt:Product_1c53045c-f69d-32cc-92d5-edd603543aa2|imgt:hasStudyProduct|imgt:StudyProduct_0756fd89-b6c2-3995-a23f-9cc99dd06136 imgt:StudyProduct_7489e0f5-8578-331c-8609-c092521b85fa|rdf:type|obo:NCIT_C174271 pubmed:20593411|dc:contributor|Posvar E imgt:11655|rdfs:label|11655 imgt:MRC_Laboratory_of_Molecular_Biology|imgt:produces|imgt:Product_c9e8b7f4-972b-3d56-b5f2-bbf6f6b1ae9f imgt:Product_f9431fba-428e-323c-9e21-0749755e9867|rdf:type|obo:NCIT_C51980 imgt:StudyProduct_fcd0ae2d-ba63-3382-af10-acc1fc95fa9b|imgt:isStudyProductOf|imgt:Product_5165f95d-de70-3e0c-9a9c-2a9dd0889401 imgt:Product_cf334a6e-5ae0-3dd4-8123-f5049b0a8300|imgt:commun_name|CLLB8 imgt:Construct_1074|rdfs:label|Construct_1074 imgt:mAb_1192|rdfs:label|mAb_1192 imgt:StudyProduct_0a9ebf98-2862-3f47-984d-b0a63bc0d12f|imgt:hasClinicalIndication|imgt:HIV-1_infection_AIDS imgt:MSTN|imgt:isTargetOf|imgt:IgG1-kappa_610 imgt:IgG1-kappa-%5BPROTEIN%5D2_900|rdfs:label|IgG1-kappa-[PROTEIN]2_900 imgt:Product_ae14f792-c7fc-3b1a-8720-eab3244c9808|imgt:commun_name|c7E3 imgt:StudyProduct_7fbbee76-70ac-3b49-b030-8b7ad9569c07|imgt:hasExpressionSystem|imgt:_CV1P_cells imgt:mAb_222|imgt:imgt_note| As of August 2009, Medarex, Inc. operates as a subsidisary of Brystol-Myers Squibb company. The two Fab’ are chemically linked as described in Russoniello C (1992) Clinical Cancer Res. 4:2237-2243 (1998) PMID: 9748144 (directed chemical coupling of the Fab’-thionitrobenzoate derivative (Fab’-TNB) of H22 with the Fab’-SH of H425). H22 F(ab') binds CD64 (FcγRI) (but outside the normal ligand binding site for IgG) and matuzumab F(ab') binds EGFR. MDX-447 directs CD64-positive effector cells (monocytes, macrophages…) to tumor cells that overexpress EGFR, to phagocyte or kill them. imgt:Product_b53d5313-835d-3d6b-8fb3-a4650e3a36ef|imgt:commun_name|BMS986414 imgt:TACSTD2|imgt:isTargetOf|imgt:IgG1-kappa_661 imgt:StudyProduct_a3e934a2-7108-3112-bed4-4bcc786852c9|imgt:isStudyProductOf|imgt:Product_e3796ae8-3883-3da0-b6f6-ea37bcf8bcb7 imgt:Chronic_lymphocytic_leukemia_(CLL)|imgt:isClinicalIndicationOf|imgt:StudyProduct_6c197f43-a8c3-3c08-adb7-14370840c9d7 imgt:IgG2-kappa_116|http://semanticscience.org/resource/SIO_000291|imgt:CEACAM5 imgt:StudyProduct_115bc04d-cd5b-3146-9ec7-c78e72875181|rdfs:label|StudyProduct_115bc04d-cd5b-3146-9ec7-c78e72875181 imgt:mAb_601|imgt:hasOriginClone|imgt:Clone_601 imgt:StudyProduct_ceb7772c-4230-3f78-9b92-e823888f62fb|rdfs:label|StudyProduct_ceb7772c-4230-3f78-9b92-e823888f62fb imgt:Segment_1272_1|rdf:type|imgt:Segment imgt:Construct_737|rdf:type|imgt:Construct imgt:Product_b18c7489-8c67-32b7-93b0-4b6452620c97|imgt:isProductOf|imgt:mAb_549 imgt:Construct_1290|imgt:hasImgtLabel|imgt:IgG1-lambda2 imgt:mAb_1109|imgt:hasMabReceptor|imgt:IgG1-lambda_1109 imgt:IgG1-kappa_677|http://semanticscience.org/resource/SIO_000291|imgt:Zaire_Ebola_virus imgt:scFv-heavy-kappa-CD8A_(CO-TM)-TNFRSF9_(CY)-CD247_1103|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/scFv-heavy-kappa-CD8A%20(CO-TM)-TNFRSF9%20(CY)-CD247.png imgt:IgG4-kappa_548|rdf:type|imgt:MAbReceptor imgt:IgG1-nd_57|imgt:hasConstruct|imgt:Construct_57 imgt:Segment_1184_1|imgt:has_rank|1 imgt:10990|rdfs:label|10990 obo:NCIT_C174894|rdf:type|owl:Class imgt:Segment_562_1|imgt:has_rank|1 imgt:mAb_1286|imgt:inn_number|12120 _:B8b8fd2d1f14c2fc37f1c2b20db144476|imgt:isDecidedBy|imgt:FDA imgt:Solid_tumors|imgt:isClinicalIndicationOf|imgt:StudyProduct_3fce70b5-9444-3ae3-9ec4-143ceeeeb147 imgt:StudyProduct_a7811b4e-4519-3e4d-87c6-9e1f3528a52a|imgt:hasClinicalIndication|imgt:Lymphoma_diffuse_large_B_cell_(DLBCL) imgt:Segment_376_1|obo:BFO_0000050|imgt:Construct_376 imgt:SCFV-GAMMA-DELTA|imgt:describes|imgt:ScFv-Gamma-Delta imgt:StudyProduct_3af4fc94-a470-31a6-b10b-f0a9c38ec2f9|rdf:type|obo:NCIT_C174271 imgt:Clone_649|rdf:type|obo:NCIT_C37925 imgt:Alopecia_areata|rdfs:label|Alopecia_areata imgt:Clone_286|obo:RO_0002162|imgt:Musmus imgt:IgG1-kappa_547|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:StudyProduct_e0e65127-cd8a-35e9-b6fc-6731cbf22051|imgt:hasClinicalPhase|imgt:Phase_M imgt:IgG1-lambda_1109|obo:RO_0002162|imgt:Hum imgt:StudyProduct_0895e1ef-0d19-3466-9423-f7b0a797c903|imgt:hasExpressionSystem|imgt:_CHOK1SV_(expresses_glutamine_synthetase_(GS)_endogenously)_cells imgt:Hepatocellular_carcinoma_(HCC)|imgt:isClinicalIndicationOf|imgt:StudyProduct_dbb4fa30-ebb4-3848-8369-46cde954502e imgt:IgG1-kappa_255|imgt:isMabReceptorOf|imgt:mAb_255 imgt:StudyProduct_ba0ee284-ffae-354b-a756-2e4106d53de8|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:Construct_547|rdf:type|imgt:Construct obo:NCIT_C171842|rdfs:subClassOf|obo:NCIT_C1909 imgt:IgG1-kappa_328|imgt:hasMolecularComponent|imgt:IG imgt:mAb_1169|imgt:hasOriginClone|imgt:Clone_1169 imgt:IgG1-kappa_771|imgt:hasConstruct|imgt:Construct_771 imgt:mAb_1067|rdfs:label|mAb_1067 imgt:D-J-C-CLUSTER|rdf:type|imgt:ComposedClusterLabel imgt:IG-Heavy-Gamma-2-a-IGHG2A|imgt:defines|imgt:Fab-Gamma-2-a_Lambda imgt:Amgen|imgt:produces|imgt:Product_f6eddd34-803e-38c4-988e-4fdccd05fd3b imgt:mAb_194|imgt:hasProduct|imgt:Product_5c0aac93-e5ec-3675-b1ef-16f7fbe485d4 imgt:DLL3|obo:RO_0002162|imgt:Homsap imgt:mAb_223|imgt:hasProduct|imgt:Product_1a5a7655-b7fd-3b5a-8928-0839477de93d _:Bbe2a3440a9ba62ac28d059c0075d7090|rdf:type|obo:NCIT_C53285 imgt:mAb_469|imgt:hasMabReceptor|imgt:IgG2-kappa_469 imgt:Segment_821_2|imgt:segment_detail|Fc (Fragment constant) imgt:IgG1-kappa_557|obo:RO_0002162|imgt:Homsap imgt:StudyProduct_9a1ace4b-c686-3cab-bf14-c4bc22f32a84|imgt:development_technology| No N-glycosylation sites CH2 N84.4A Antibody phage display library imgt:CSF3R|imgt:isTargetOf|imgt:CARRIER_BIG-PROTEIN_1DOMAIN_691 imgt:IgG1-kappa/lambda_with_domain_crossover_trivalent|rdf:type|imgt:ConstructLabels imgt:Product_ceb3912e-1a2a-3355-bb97-cead13a7b3ac|rdfs:label|Product_ceb3912e-1a2a-3355-bb97-cead13a7b3ac imgt:mAb_967|imgt:hasMabReceptor|imgt:IgG1-kappa-4lys-drug_967 imgt:Product_856b0b55-813b-3ad1-b994-aaca500e9da0|rdfs:label|Product_856b0b55-813b-3ad1-b994-aaca500e9da0 imgt:FPIA_%5BPROTEIN_VLIKE%5D2-1S-FC_247|rdfs:label|FPIA_[PROTEIN_VLIKE]2-1S-FC_247 imgt:StudyProduct_3da0db8d-1eec-321a-9900-792118d84944|imgt:hasClinicalPhase|imgt:Phase_I imgt:IgG4-kappa_155|obo:RO_0002162|imgt:Chi imgt:IgG1-kappa_720|rdfs:comment|IgG1 - kappa imgt:IgG4-kappa_1148|rdfs:label|IgG4-kappa_1148 imgt:IgG1-nd_280|http://semanticscience.org/resource/SIO_000291|imgt:ITGB2 imgt:Construct_733|imgt:hasImgtLabel|imgt:%5BTNFRSF1B_(tumor_necrosis_factor_receptor_(TNFR)_superfamily_member_1B_TNFBR_p75_CD120b)%5D2-IGHG1_Fc_(Fragment_constant) imgt:StudyProduct_ceba4d0e-cc6a-3368-b840-e44fe0b4bfcb|imgt:isStudyProductOf|imgt:Product_f2202260-1eb1-3ea7-b7bb-a7ab1d7930ea imgt:mAb_568|imgt:hasOriginClone|imgt:Clone_568 imgt:Product_d91e5891-3b22-3421-a448-2fa088684e64|imgt:isProductOf|imgt:mAb_762 imgt:Product_8bc22827-09a3-3eb0-9e53-3f97c122310c|imgt:isProducedBy|imgt:Sutro_Biopharma_Inc imgt:Product_a9814a14-a170-37d5-97fd-0fe8732330c2|imgt:commun_name|tralokinumab-idrm imgt:mAb_758|imgt:hasMabReceptor|imgt:IgG1-kappa_758 imgt:Product_4a76dcbb-71d0-3976-a73c-e3c49cbaf19f|imgt:hasStudyProduct|imgt:StudyProduct_75d253d7-82de-38d0-bb06-ec931e28c1e1 imgt:diabody|rdfs:label|diabody imgt:Product_c8f3b081-bdf9-3d9e-b6ca-5c7797adc6ad|rdfs:label|Product_c8f3b081-bdf9-3d9e-b6ca-5c7797adc6ad imgt:Immediate-type_hypersensitivities|rdfs:label|Immediate-type_hypersensitivities imgt:mAb_355|imgt:hasBibliographicReference|pubmed:20035694 imgt:Bayer_AG|imgt:produces|imgt:Product_0142f6fe-7297-3e48-855f-ae8298ad4948 imgt:mAb_196|rdf:type|obo:NCIT_C1857 imgt:StudyProduct_0baef6f2-681e-353b-8a76-324497b508a0|rdf:type|obo:NCIT_C174271 imgt:Roche_F_Hoffmann-La_Roche_Ltd|imgt:produces|imgt:Product_3b6c9b0a-cdb1-35e8-a5ba-246fdbd685e6 imgt:Alkermes_Inc|rdfs:label|Alkermes, Inc. imgt:PDCD1|imgt:isTargetOf|imgt:IgG1-kappa_1093 imgt:G-ALPHA1|rdfs:label|G-ALPHA1 obo:NCIT_C91073|rdf:type|owl:Class imgt:Clone_138|imgt:isOriginCloneOf|imgt:mAb_138 imgt:Segment_526_1|obo:BFO_0000050|imgt:Construct_526 imgt:Product_8deb0f9b-5b13-309d-a50b-a0f5692743cc|imgt:commun_name|PRO145223 imgt:mAb_969|imgt:inn_recommended_list|83 (2020) imgt:Product_8e4f31af-8bb6-303e-b57e-d15ba5bd4075|imgt:commun_name|BMS 986413 imgt:StudyProduct_e3ffb74c-0ceb-3d93-adaa-56c66b4f3b79|imgt:development_technology| Cambridge Antibody Technology (CAT) human antibody phage display library imgt:IL13RA1|rdfs:label|IL13RA1 imgt:StudyProduct_75e6e634-f0fd-314d-9477-c9ed24c39da7|rdfs:label|StudyProduct_75e6e634-f0fd-314d-9477-c9ed24c39da7 _:B9fbc0aee9b03c91f0d9e484b9f3b4363|rdf:type|obo:NCIT_C53285 imgt:mAb_837|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=837 imgt:10068|imgt:isImgtStructureEntryOf|imgt:mAb_539 imgt:_Sp2/0_mouse_hybridoma_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_71208dab-9f1e-3a59-b5e7-e15f341ef594 imgt:CPCA_PROTEIN_BIG-FC_520|imgt:fused_with| Homo sapiens IGHG1 Fc (Fragment constant) imgt:Segment_216_2|rdf:type|imgt:Segment _:B6f879dbd963a642f6949c2d13d2e5a1c|rdf:type|obo:NCIT_C53285 obo:NCIT_C171659|rdfs:subClassOf|obo:NCIT_C1909 imgt:mAb_1239|imgt:imgt_note| On Jan 1, 2019, HJB and MabSpace Biosciences announce the fusion of the two companies to creat Transcenta Holding Ltd. (Transcenta), a fully-integrated biotherapeutics company. imgt:mAb_1054|imgt:hasImgtStructureEntry|imgt:11181 _:B8227e98020208d12ba38cb8da151085d|imgt:hasDesignation|imgt:Orphan_drug imgt:mAb_460|imgt:inn_proposed_list|108 (2012) imgt:Product_69e0603e-e62c-3164-b2bd-120ef0150778|imgt:isProducedBy|imgt:Ablynx imgt:StudyProduct_ab7d8ffc-9070-3c4e-afbf-5efec0fbe8cc|rdf:type|obo:NCIT_C174271 imgt:Product_5a490e25-bdeb-3fc5-b45d-f7095463e64a|imgt:isProductOf|imgt:mAb_133 imgt:Cancers_non-small_cell_lung_(NSCLC)_metastatic|imgt:isClinicalIndicationOf|imgt:StudyProduct_8c63dc3d-4414-3596-928d-549fc6f3f5b1 imgt:mAb_743|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=743 imgt:IgG1-kappa_542|imgt:hasConstruct|imgt:Construct_542 imgt:mAb_703|imgt:hasMabReceptor|imgt:PEPTIDE-XTEN_703 imgt:CH9|skos:definition|C-DOMAIN corresponding to the CH9 exon coding region from an IG-HEAVY (H) chain imgt:mAb_914|rdfs:label|mAb_914 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imgt:mAb_668|imgt:inn_name|trastuzumab duocarmazine imgt:StudyProduct_b0f8b305-45b5-3570-abf5-1a449100c74f|rdf:type|obo:NCIT_C174271 imgt:mAb_940|imgt:inn_number|11081 imgt:Construct_399|rdf:type|imgt:Construct _:Ba6b18a5e34ed017363b193153d36b515|imgt:hasStatut|imgt:approval imgt:MAbReceptor_995|rdfs:label|MAbReceptor_995 imgt:mAb_471|imgt:inn_proposed_list|109 (2013) imgt:Valerion_Therapeutics_LLC|imgt:produces|imgt:Product_b9011a57-4c7b-38e5-bb1c-72744125b5ae imgt:StudyProduct_b9fb63c1-ee3a-3ff7-9818-887d08e9cf4c|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_6c878ada-1306-3956-b6b2-ee886b0c2e29|rdfs:label|StudyProduct_6c878ada-1306-3956-b6b2-ee886b0c2e29 imgt:StudyProduct_dde1e1c5-0a3b-3aa6-a5df-6ed0e81a8b4f|imgt:hasClinicalIndication|imgt:Hepatitis_C pubmed:1836485|dc:contributor|Hehir K. imgt:Product_85bf09db-dcaa-3c16-83c2-0e68aaabd997|imgt:isProductOf|imgt:mAb_350 imgt:StudyProduct_04a588ca-f4e9-3453-8e00-e517064379bc|imgt:development_technology| Dyax human antibody phage display 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imgt:StudyProduct_8d2cc527-78b9-30c5-a46b-4b4b537a04c2|rdf:type|obo:NCIT_C174271 imgt:mAb_854|imgt:inn_recommended_list|81 (2019) imgt:Clone_233|obo:RO_0002162|imgt:Musmus imgt:StudyProduct_a4a8aabd-1831-3836-9235-8d194bfab559|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_3ca3e910-358e-307b-a4aa-fa5f618d3333|imgt:isStudyProductOf|imgt:Product_c10a43ba-cfd6-3610-84b1-dabd23fd8ede _:Be24e72476432021dfc6c0010dd88c1ea|imgt:isDecisionOf|imgt:StudyProduct_8715a821-0f47-3ff3-8cf0-198932485980 imgt:Biogen_Inc|imgt:produces|imgt:Product_dfacdb0c-b486-3d1e-aa2b-38d3b8a8a4ee obo:NCIT_C71015|rdf:type|owl:Class imgt:Segment_525_1|imgt:segment_detail|(engineered with a PSA cutting site) imgt:Segment_82_2|rdf:type|imgt:Segment imgt:Segment_301_1|imgt:has_rank|1 imgt:Clone_783|imgt:isOriginCloneOf|imgt:mAb_783 _:B99beaa92ec1285a5f38148d252b33c7a|imgt:isDecisionOf|imgt:StudyProduct_b9782cd6-eaaa-3fb3-ad90-ce4d8add7cf8 imgt:SLC34A2|rdfs:label|SLC34A2 imgt:StudyProduct_d84bded9-4720-3ab6-acaf-6d8202bfa9d7|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:Chronic_Obstructive_Pulmonary_Disease_(COPD)|imgt:clinical_domain|Pulmonary, Respiratory diseases _:B8c4443f61e21b93363b84bac9438e7cc|imgt:isDecidedBy|imgt:Japan_(MHLW) imgt:IgG1-nd_104|imgt:isMabReceptorOf|imgt:mAb_104 imgt:StudyProduct_0cf110d5-c16d-3145-883f-5cb8cb26f2aa|imgt:isStudyProductOf|imgt:Product_355d2e91-32c9-3c39-a152-f1a44b1155d5 imgt:Clone_379|rdfs:label|Clone_379 imgt:mAb_526|imgt:hasImgtStructureEntry|imgt:5X8L imgt:FPIA_%5BPROTEIN%5D2-FC_388|obo:RO_0002162|imgt:Homsap imgt:Segment_687_2|obo:BFO_0000050|imgt:Construct_687 imgt:Construct_367|obo:BFO_0000051|imgt:Segment_367_1 imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_81683a1e-9f05-3c20-9ce5-1795547f315b imgt:Product_dc2a0795-349d-373b-be05-d16cf2186843|imgt:commun_name|coagulation Factor IX (recombinant)- Fc fusion protein imgt:IgG1-kappa_90|rdf:type|imgt:MAbReceptor imgt:isProducedBy|rdfs:range|obo:NCIT_C54131 imgt:Product_530cd937-ccd1-3ccd-841c-76f410657af5|imgt:hasStudyProduct|imgt:StudyProduct_da8d123f-612d-3398-a0e9-9b0a0692bac5 imgt:Tn3-ALB_1117|imgt:fused_with| ALB (albumin, human serum albumin, HSA) imgt:Construct_340|imgt:isConstructOf|imgt:IgG1-kappa_340 imgt:APCS_(Pr20-223)|rdf:type|imgt:ChainLabels imgt:Product_3c3fcf8d-d19d-34ce-b042-90ea8dff0aa9|rdf:type|obo:NCIT_C51980 imgt:StudyProduct_d216a0b8-7a7d-3879-acc2-f980a11469c4|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_f42d36b7-ee30-3f25-b843-c786a875bc89|imgt:application_type|Therapeutic imgt:11067|rdf:type|obo:NCIT_C25402 _:Bbc4858d69ee31006a2a3bfbdc26b94d0|dc:date|2010-10-21 imgt:9798|rdfs:label|9798 imgt:IgG2-kappa-%5BPROTEIN%5D2_908|http://semanticscience.org/resource/SIO_000291|imgt:ICOSLG imgt:hulio™|rdf:type|obo:NCIT_C156644 imgt:StudyProduct_8fafb39d-a882-31f1-80c7-29f8cbf3627b|imgt:isStudyProductOf|imgt:Product_92aaaa11-a012-35e5-91ee-9df570fa89a7 _:B11fd41f41ead1532b4c3b5f39a7db635|imgt:hasStatut|imgt:approval imgt:StudyProduct_6ce03f46-14e1-3938-8d6d-b2809b5396d6|rdfs:label|StudyProduct_6ce03f46-14e1-3938-8d6d-b2809b5396d6 imgt:IgG1-kappa_479|rdfs:comment|IgG1 - kappa imgt:Segment_376_1|rdf:type|imgt:Segment imgt:mAb_662|imgt:inn_recommended_list|80 (2018) imgt:Product_01a1bc2c-213a-3e68-b062-36ba9d5d7cd7|rdf:type|obo:NCIT_C51980 _:Bc7691881e5071c0b35e150ea506b4bb7|imgt:hasStatut|imgt:approval obo:NCIT_C170271|rdfs:subClassOf|obo:NCIT_C1909 imgt:StudyProduct_629b5f50-da7b-35be-ab43-a961802999fb|rdfs:label|StudyProduct_629b5f50-da7b-35be-ab43-a961802999fb imgt:StudyProduct_dd88f5dd-8d77-3766-9219-118b017a5fe6|imgt:development_technology| No N-glycosylation sites CH2 N84.4A Antibody phage display library imgt:mAb_1169|imgt:inn_name|galegenimab imgt:Product_5de6a99e-dedd-3ea1-be46-1a994fd0890e|imgt:commun_name|MT228 imgt:StudyProduct_3b05e51f-a753-36a4-8c40-4bc1472d53d5|imgt:application_type|Therapeutic imgt:mAb_1287|rdfs:label|mAb_1287 imgt:StudyProduct_3d6f46be-763a-3ce2-b8b0-cf79e8a37244|imgt:application_type|Therapeutic pubmed:7695263|dc:contributor|Hsu SA imgt:StudyProduct_f8ea0962-96ab-3f9b-80d2-b5d260255e59|imgt:application_type|Therapeutic imgt:Segment_935_1|imgt:hasImgtLabel|imgt:TNFSF18 imgt:StudyProduct_3b1ae0f9-fbe1-3c51-8b11-217af9857a4b|imgt:isStudyProductOf|imgt:Product_7c5b4231-8351-3ed9-ba1d-8c48699ed506 imgt:StudyProduct_1262459b-5fb7-3613-be73-bb5ee75f51e3|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:StudyProduct_8619b3f1-9d63-3ba3-81c5-60a74bc84295|imgt:isStudyProductOf|imgt:Product_36113e7c-404a-35ad-8f60-78bdc8d88db9 imgt:StudyProduct_1a64ef25-30ed-3988-9d19-9bfcc5d21705|imgt:hasClinicalIndication|imgt:GE_Junction_Cancer imgt:Bone_marrow_scintigraphy|rdfs:label|Bone_marrow_scintigraphy imgt:SORT1|rdfs:label|SORT1 imgt:Construct_879|rdfs:label|Construct_879 imgt:(VH-CH2-CH3)2_S_934|rdfs:comment|(VH-CH2-CH3)2_S imgt:Construct_455|rdf:type|imgt:Construct imgt:IgG2-kappa_277|imgt:hasMolecularComponent|imgt:IG _:B2df5898b6be90aa6666e0742921b8017|imgt:hasDesignation|imgt:Orphan_drug imgt:mAb_1113|rdf:type|imgt:INN imgt:StudyProduct_09cb89dc-7fb2-3f6a-980e-48d78bdb7716|imgt:isStudyProductOf|imgt:Product_ad630571-be3a-37d0-b30d-5b4667c2c49a imgt:Segment_565_1|imgt:has_rank|1 imgt:Segment_799_1|rdf:type|imgt:Segment imgt:5ID0|rdf:type|obo:NCIT_C25402 imgt:mAb_1006|imgt:inn_recommended_list|84 (2020) imgt:StudyProduct_1203e490-9d6a-3d75-be80-4d3b7b3081d3|rdfs:label|StudyProduct_1203e490-9d6a-3d75-be80-4d3b7b3081d3 imgt:StudyProduct_bc96394e-4266-3b0c-9ff1-ec9e290b0e3f|imgt:isStudyProductOf|imgt:Product_dc0aef01-f52d-3832-923a-55c9be5361e7 imgt:Construct_1265|rdfs:label|Construct_1265 imgt:Syndax_Pharmaceuticals_Inc|rdf:type|obo:NCIT_C54131 imgt:Psoriasis|imgt:isClinicalIndicationOf|imgt:StudyProduct_9591fc69-98a7-3e94-8c54-e2bbed0c8387 imgt:IgG1-nd_270|rdf:type|imgt:MAbReceptor imgt:StudyProduct_e9b87722-0d14-35a4-a37e-fbe53bca414e|imgt:hasClinicalPhase|imgt:Phase_I imgt:StudyProduct_5c49e8b8-2845-3495-b1cf-801b59fe3edb|rdf:type|obo:NCIT_C174271 imgt:SIGLEC8|imgt:isTargetOf|imgt:IgG1-kappa_832 imgt:StudyProduct_caefcc10-c9e9-3bb3-8576-158012138944|imgt:application_type|Therapeutic imgt:Product_ac26bf9e-d13c-36c7-8908-f733d1ba52d3|imgt:isProductOf|imgt:mAb_1089 imgt:StudyProduct_9ca532b7-4f84-3ca1-b57f-fff0036e4dd4|imgt:isStudyProductOf|imgt:Product_35874c60-bbc8-3078-95f7-d5da364ab3b8 imgt:IgG1-kappa_1150|imgt:hasMolecularComponent|imgt:IG _:B2df5898b6be90aa6666e0742921b8017|imgt:isDecisionOf|imgt:StudyProduct_f5830fbe-63ca-3d3f-999b-81b658186793 imgt:Solid_tumors|imgt:isClinicalIndicationOf|imgt:StudyProduct_ce2a9107-8d5c-351f-b0b8-b0e9eb71adbd _:Be905dbb34cb8d3f2f73c1842459a69b6|imgt:isDecisionOf|imgt:StudyProduct_3dd692d6-3588-3e54-b7d2-4aa41709d4a4 imgt:Construct_1002|imgt:isConstructOf|imgt:IgG4-kappa_1002 imgt:Segment_1277_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:FUSION-ALB-CSF3|rdf:type|imgt:CPCALabel imgt:StudyProduct_0b2dfcc7-9a67-3933-91c8-fec9296019f5|imgt:application_type|Therapeutic imgt:Fd|rdf:type|imgt:FormatType imgt:Solid_tumors|imgt:isClinicalIndicationOf|imgt:StudyProduct_3a79660d-28dd-32ba-80a4-f8b0b72a381e imgt:VLRC|rdf:type|imgt:ChainLabels imgt:Construct_432|obo:BFO_0000051|imgt:Segment_432_1 imgt:IgG1-kappa_958|http://semanticscience.org/resource/SIO_000291|imgt:CD276 imgt:Graft-versus-host_disease_(GvHD)_acute|imgt:isClinicalIndicationOf|imgt:StudyProduct_87007e39-9ed3-3b6d-823a-59a1e99759cd imgt:StudyProduct_4bf71638-3473-3ec8-aad8-2660c8cb6487|imgt:application_type|Therapeutic imgt:Product_33c97ddf-49a2-3444-885e-824d06bac68c|imgt:hasStudyProduct|imgt:StudyProduct_4b851f49-d7ec-3723-ad3b-48dd091181b6 imgt:TGM2|rdf:type|obo:NCIT_C25702 imgt:Segment_867_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:StudyProduct_070ab1b3-b643-3e97-9402-cd0f6416d1e7|rdf:type|obo:NCIT_C174271 imgt:IgG2-kappa_910|imgt:hasConstruct|imgt:Construct_910 imgt:mAb_1058|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=1058 imgt:Construct_702|obo:BFO_0000051|imgt:Segment_702_2 imgt:StudyProduct_29e10680-7e7d-30a4-9681-0ec6a25c7fed|rdf:type|obo:NCIT_C174271 imgt:CD247_(Pr52-164)|rdf:type|imgt:DomainLabel imgt:mAb_1269|imgt:hasMabReceptor|imgt:IgG1-kappa-4cys-drug_1269 imgt:StudyProduct_a2cf14ef-242a-32b4-817c-814f3fcb2e78|imgt:application_type|Therapeutic imgt:StudyProduct_1e229310-9aad-3ecc-8c4a-dd2c86815e72|imgt:hasExpressionSystem|imgt:_CHO-K1 imgt:mAb_132|imgt:inn_recommended_list|29 (1989) imgt:mAb_584|imgt:clinical_trials|35 studies found, 4 recruiting _:Baf347226fbf0b9f9efb69ba637202e1c|rdf:type|obo:NCIT_C53285 imgt:mAb_281|imgt:inn_proposed_list|84 (2000) imgt:StudyProduct_3f06c08f-d26e-30b2-9344-72cf4676c965|rdf:type|obo:NCIT_C174271 imgt:Product_7cd6bccd-e113-3f71-b694-1ad929718792|imgt:isProducedBy|imgt:Gilead imgt:mAb_170|imgt:imgt_note| Origine clone from Cambridge Antibody Technology (CAT) library (Cambridge UK) imgt:mAb_502|imgt:hasProduct|imgt:Product_6b5f5f16-7cf5-39b5-b310-37815f8f0675 obo:NCIT_C82492|rdf:type|owl:Class imgt:Clone_45|rdfs:label|Clone_45 imgt:J-C-LIKE|skos:definition|coding region of an IGLL gene comprising a J-LIKE and a C-LIKE, in gDNA or cDNA imgt:CFD|imgt:isTargetOf|imgt:Fab-G1-kappa_421 imgt:StudyProduct_eddce4b1-d3b9-3401-aa99-97fb0942bd9a|rdf:type|obo:NCIT_C174271 imgt:IgG2-kappa_939|imgt:isMabReceptorOf|imgt:mAb_939 imgt:IgG1-kappa_329|rdf:type|imgt:MAbReceptor pubmed:1873503|dc:contributor|Eda Y imgt:mAb_838|rdfs:label|mAb_838 imgt:StudyProduct_0e86d636-1d21-31ac-b437-0525a1697ae1|imgt:application_type|Therapeutic imgt:StudyProduct_eadc8a8f-1e3e-316e-bd6b-00fcf4f61f0a|imgt:isStudyProductOf|imgt:Product_8aedac6e-b419-31fb-9ff4-442f5cc9176a imgt:Product_6082be18-1302-36ab-8a6c-75b884b65d62|imgt:isProductOf|imgt:mAb_1064 imgt:StudyProduct_98cfbff5-18f3-3691-9aae-50c4c87cc27f|imgt:hasClinicalIndication|imgt:Lymphoma_follicular_(FL) imgt:Product_e3009342-baa5-36fb-ad94-0743b8782e11|imgt:isProductOf|imgt:mAb_450 imgt:is_completed|rdfs:domain|faldo:Region imgt:IgG1-lambda_943|imgt:isMabReceptorOf|imgt:mAb_943 imgt:IgG4-kappa_424|imgt:hasMolecularComponent|imgt:IG imgt:StudyProduct_94bed1e7-0c3a-3eb5-9087-72b06c2758dc|imgt:application_type|Therapeutic imgt:mAb_1055|rdf:type|obo:NCIT_C175778 imgt:mAb_1135|imgt:hasOriginClone|imgt:Clone_1135 imgt:mAb_679|imgt:inn_number|10569 imgt:Segment_486_1|imgt:has_rank|1 imgt:StudyProduct_0baedbe6-1604-34c0-94ab-a794447ae333|imgt:hasClinicalPhase|imgt:Phase_I imgt:IgG1-kappa_177|obo:RO_0002162|imgt:Homsap imgt:Segment_413_1|rdf:type|imgt:Segment imgt:StudyProduct_a1840dbf-d7a6-36f3-ade2-38b0230f6021|imgt:hasClinicalIndication|imgt:Cancers_ovarian imgt:mAb_814|rdf:type|imgt:INN imgt:Construct_1265|rdf:type|imgt:Construct imgt:StudyProduct_53334127-51ec-3e46-bb66-71919e3cce29|imgt:hasClinicalIndication|imgt:Carcinoma_nasopharyngeal_(NC) imgt:Hemophilia_B|rdf:type|obo:NCIT_C185637 imgt:Obesity|rdfs:label|Obesity imgt:10041|rdfs:label|10041 imgt:StudyProduct_1f9cf058-4df4-349c-9eb0-350307f94e31|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:IgG4-kappa_1198|obo:RO_0002162|imgt:Hum imgt:Systemic_lupus_erythematosus_(SLE)|imgt:isClinicalIndicationOf|imgt:StudyProduct_2885244f-5d5a-36a6-b367-fb9982d41711 imgt:Construct_732|rdf:type|imgt:Construct imgt:IL21R|skos:definition|IL21R (interleukin 21 receptor, CD360) imgt:StudyProduct_5e4d56c3-87f8-365e-b05c-33017bfd1933|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_723687d1-7878-30f1-987e-b1bc5e2c19ec|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_9a1ace4b-c686-3cab-bf14-c4bc22f32a84|imgt:isStudyProductOf|imgt:Product_406390c3-6cd8-3629-be68-66016fce19cf imgt:PROTEIN_1DOMAIN_707|rdfs:comment|PROTEIN_1DOMAIN imgt:Product_1e2fc063-05b8-30f0-827b-f5ed40b8c74a|imgt:isProducedBy|imgt:Genentech_Inc imgt:Segment_613_3|obo:BFO_0000050|imgt:Construct_613 _:Bea82df7678774d8fc36bd200dd1cd880|rdf:type|obo:NCIT_C53285 imgt:IgG1-lambda_535|imgt:hasMolecularComponent|imgt:IG imgt:mAb_278|imgt:inn_recommended_list|48 (2002) imgt:StudyProduct_87fffe94-ae1a-3006-a8ee-be81eb91dd75|imgt:application_type|Therapeutic imgt:Product_5c98d66d-fb8c-3e2a-b2cf-162c528ac706|imgt:comercial_name|PRALUENT® imgt:D-(DJ)-C-CLUSTER|owl:sameAs|obo:SO_0000504 imgt:StudyProduct_f8da3f77-3733-32fd-b4fc-d5ef2bae5cfb|imgt:isStudyProductOf|imgt:Product_b9a7e713-902d-3fb3-afff-5da968f3c336 imgt:StudyProduct_8ea9cb56-50d7-3016-a7f3-8606e22666dc|rdfs:label|StudyProduct_8ea9cb56-50d7-3016-a7f3-8606e22666dc imgt:Clone_46|obo:RO_0002162|imgt:Musmus 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Engineering Technology imgt:mAb_661|imgt:inn_name|sacituzumab imgt:StudyProduct_8adbb782-4619-32a3-9dc4-7daef2f29f39|imgt:hasClinicalIndication|imgt:Multiple_myeloma_(MM) _:B2a33f89c75c59902ee6c37e6b6cb0e4d|rdf:type|obo:NCIT_C53285 imgt:IgG1-kappa_770|rdfs:label|IgG1-kappa_770 imgt:Segment_1203_1|imgt:hasImgtLabel|imgt:IgG4-kappa imgt:FUSION-FZD8-GAMMA-1|rdfs:label|FUSION-FZD8-GAMMA-1 imgt:Allergene|rdf:type|obo:NCIT_C54131 https://doi.org/10.1038/321522a0|rdf:type|bibo:Article imgt:Product_824a35bb-e1eb-3559-99fa-ab9a1858d010|imgt:commun_name|NGR-TNF imgt:Solid_organ_transplantation|imgt:isClinicalIndicationOf|imgt:StudyProduct_9d6939c7-c15c-3d8d-99a8-995f6f32275b obo:NCIT_C166690|rdfs:subClassOf|obo:NCIT_C1909 imgt:Product_ae9d0ef1-9d15-3162-85b2-0e3e7f359fec|rdfs:label|Product_ae9d0ef1-9d15-3162-85b2-0e3e7f359fec imgt:Segment_1265_1|obo:BFO_0000050|imgt:Construct_1265 imgt:C-LIKE|skos:definition|constant (C) domain similar to an IG or TR C-DOMAIN, found in immunoglobulin superfamily (IgSF) proteins other than IG or TR imgt:Clone_45|rdf:type|obo:NCIT_C37925 _:Ba166c0b97e46582cfe441bceee6c3091|imgt:isDecidedBy|imgt:EC imgt:CD14|skos:definition|CD14 imgt:Wellcome|imgt:produces|imgt:Product_04732c56-2fa2-382b-bddc-28429ab285c5 imgt:VH-VH_401|http://semanticscience.org/resource/SIO_000291|imgt:VWF imgt:mAb_728|imgt:inn_proposed_list|116 (2016) imgt:StudyProduct_b273692a-ef6a-35d7-84f1-c9019bdc6d3d|rdf:type|obo:NCIT_C174271 _:B365b9b206909b8e3e271ba494de2fc55|rdf:type|obo:NCIT_C53285 _:B347b970e757b284215efb8aeca508657|imgt:isDecisionOf|imgt:StudyProduct_8162d513-eb16-3f06-a0e7-62382a7339e1 pubmed:1560463|dc:contributor|Foote J. imgt:Product_c7810095-aebe-3853-904f-69aab48efb59|rdfs:label|Product_c7810095-aebe-3853-904f-69aab48efb59 imgt:Segment_138_1|rdfs:label|Segment_138_1 imgt:10420|imgt:isImgtStructureEntryOf|imgt:mAb_662 pubmed:25788700|dc:contributor|Öster L imgt:Segment_496_1|imgt:has_rank|1 imgt:Product_09c01ca5-976f-3de9-81cb-3dc784cbc65f|rdfs:label|Product_09c01ca5-976f-3de9-81cb-3dc784cbc65f imgt:mAb_301|imgt:inn_proposed_list|101 (2009) imgt:Product_5fe27d5e-9dfb-3d39-8194-dd812554970a|imgt:isProducedBy|imgt:Akero_Therapeutics imgt:mAb_39|imgt:hasBibliographicReference|pubmed:1798701 imgt:IgG4-kappa_241|rdfs:label|IgG4-kappa_241 imgt:StudyProduct_4ceeafbd-cd1c-3ed8-9980-a390e57b69f6|imgt:application_type|Therapeutic imgt:_Sp2/0_mouse_hybridoma_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_5ff62102-e848-3f73-a032-36953e1cfc52 imgt:IgG1-kappa_1114|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:StudyProduct_393a9101-6f44-3cff-855c-d1a42fcc9d31|imgt:application_type|Therapeutic imgt:PROTEIN_1DOMAIN_682|rdf:type|imgt:MAbReceptor imgt:CD276|rdfs:label|CD276 imgt:11182|rdf:type|obo:NCIT_C25402 imgt:mAb_382|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=382 imgt:bi-component_leukocidins|imgt:isTargetOf|imgt:IgG1-kappa_763 imgt:Product_8e8a1379-1ce0-3a6f-bd30-ded74b8a8b53|imgt:comercial_name|RITUXAN® imgt:MAbReceptor_145|rdfs:label|MAbReceptor_145 imgt:Muscle_atrophy_due_to_orthopedic_disuse|rdf:type|obo:NCIT_C185637 imgt:mAb_1209|imgt:inn_number|11878 _:B01a62006669157e27f2ba94a61089c13|dc:date|2015-10-23 imgt:mAb_1297|imgt:inn_proposed_list|126 (2022) _:B6262a01e127f92cce188edb49a63eff2|rdf:type|obo:NCIT_C53285 imgt:mAb_219|imgt:inn_proposed_list|93 (2005) imgt:mAb_135|imgt:hasMabReceptor|imgt:IgG1-kappa_135 imgt:VH-CH1-V-LAMBDA-CH1-CH2-CH3|skos:definition|Chain or receptor comprising one VH, one CH1, one V-LAMBDA,one CH1, one CH2 and one CH3 domains imgt:mAb_663|imgt:hasOriginClone|imgt:Clone_663 imgt:StudyProduct_4c297422-ee66-3012-88ea-315e69f171c0|rdfs:label|StudyProduct_4c297422-ee66-3012-88ea-315e69f171c0 imgt:Construct_1054|rdf:type|imgt:Construct imgt:StudyProduct_3382d51d-375a-381d-b60d-bae05535edfa|rdf:type|obo:NCIT_C174271 imgt:Product_5f7de253-d7f2-3582-8476-9ba479bbba35|imgt:commun_name|Lym-1 imgt:IgG2-kappa_102|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG2-kappa.png imgt:mAb_275|imgt:hasImgtStructureEntry|imgt:8241 _:Bc4bc2a15f227f8bb7e7f2b94c5b3a4f0|imgt:isDecisionOf|imgt:StudyProduct_54c8df76-003b-3fb6-ae0b-a64c19682dd5 imgt:Johnson_&_Johnson|imgt:produces|imgt:Product_ca415bf9-d43d-31ef-b23e-bec5b4023720 pubmed:25788700|dc:contributor|Gennemark P imgt:StudyProduct_752e70d2-579b-3561-9749-03044f0090ff|imgt:hasClinicalIndication|imgt:Diabetic_macular_edema imgt:Product_9d05b768-40c8-3287-9fc9-b1c8d5a35139|rdfs:label|Product_9d05b768-40c8-3287-9fc9-b1c8d5a35139 imgt:StudyProduct_82fd7c74-ea4a-3e37-ba9a-116be9109767|rdfs:label|StudyProduct_82fd7c74-ea4a-3e37-ba9a-116be9109767 imgt:Construct_334|imgt:isConstructOf|imgt:IgG1-kappa_334 imgt:Product_dc2f5235-fb7e-3f30-8b2b-21b7f0c16de7|rdf:type|obo:NCIT_C51980 imgt:Product_4567b158-71e6-3aab-97f8-559512f41894|rdfs:label|Product_4567b158-71e6-3aab-97f8-559512f41894 imgt:Sinusitis|imgt:isClinicalIndicationOf|imgt:StudyProduct_eadc8a8f-1e3e-316e-bd6b-00fcf4f61f0a _:B4dc91c793c3122a1ef9631c78ce00e65|dc:date|2015-07-24 _:Be09485c99ed6c8e237e3695b04c7ed7f|dc:date|2018-12-17 imgt:mAb_601|imgt:hasProduct|imgt:Product_8e3c67b3-d78e-3d94-8195-ee6b6b36123d _:B635d11798f53d3d022135d0d41699aa5|imgt:hasStatut|imgt:withdrawal imgt:Regeneron_Pharmaceuticals_Inc|imgt:produces|imgt:Product_93d90694-9b47-3eae-b28a-c98b642a9eaf imgt:Product_950458ce-5b79-3a87-87fd-0d76107f13a3|imgt:hasStudyProduct|imgt:StudyProduct_296f279e-8084-328b-b38c-9b44cf4d7e5b imgt:IgG4-kappa_75|rdfs:comment|IgG4 - kappa imgt:Product_8faedd00-17b0-312c-ae14-110c5b02880a|imgt:isProducedBy|imgt:Celltech_UCB imgt:Construct_118|rdf:type|imgt:Construct imgt:mAb_610|imgt:hasProduct|imgt:Product_6fff76bc-baa0-3e3c-9cf8-839e804eb2ac imgt:CPCA_%5BPROTEIN_BIG%5D2-XTEN-FC_701|obo:RO_0002162|imgt:Homsap _:Be538613d9a0ea4426782f5b5076b3f88|imgt:isDecidedBy|imgt:FDA imgt:StudyProduct_25482c39-e030-3f24-9417-7ce53ca06ee7|rdfs:label|StudyProduct_25482c39-e030-3f24-9417-7ce53ca06ee7 imgt:StudyProduct_e5f9bc32-80ee-33ea-9c6d-c28d60583c72|rdfs:label|StudyProduct_e5f9bc32-80ee-33ea-9c6d-c28d60583c72 imgt:mAb_265|rdfs:label|mAb_265 imgt:9092|rdf:type|obo:NCIT_C25402 imgt:StudyProduct_2b026931-8246-31c2-8c11-14db9cb64ebf|imgt:hasClinicalPhase|imgt:Phase_I imgt:StudyProduct_8483c2ef-bfdc-3068-9769-356981862caa|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_512bbeb9-166f-3f71-b090-1ce5e288ee49|rdf:type|obo:NCIT_C174271 imgt:Segment_1184_1|rdf:type|imgt:Segment imgt:toxin_B|rdfs:label|toxin B imgt:Clone_1184|rdf:type|obo:NCIT_C37925 imgt:StudyProduct_68e8a80f-02f1-37fa-acb5-e1842c42cfaf|rdf:type|obo:NCIT_C174271 imgt:9475|rdfs:label|9475 imgt:IFNAR2|skos:definition|IFNAR2 (interferon type I receptor subunit 2) imgt:MH1LIKE-ALPHA|rdfs:label|MH1LIKE-ALPHA imgt:LYPD3|obo:RO_0002162|imgt:Homsap imgt:mAb_595|imgt:hasProduct|imgt:Product_1347b8d4-9a42-3310-99c5-0cd1d5891625 imgt:mAb_146|imgt:hasProduct|imgt:Product_704a95ca-527f-35a5-9876-3e1298544145 imgt:IgG4-nd_614|imgt:isMabReceptorOf|imgt:mAb_614 imgt:Product_43770def-58de-3eca-8895-b84dbe04fcfa|imgt:commun_name|Fab C225 _:B517fdf295ffc2eab097e349b294f3aeb|dc:date|2018-12-21 imgt:StudyProduct_2187556f-7069-36fb-a3b5-1eac6983f1c9|imgt:hasClinicalPhase|imgt:Phase_I imgt:VH-VH%27-h-CH2-CH3_1127|imgt:hasConstruct|imgt:Construct_1127 imgt:StudyProduct_dae5d81d-0d3a-3559-9a25-4829888c5e83|imgt:hasDecision|_:B5766a3193fa23c55b69f31bdf9de7a52 imgt:%5BAXL_(AXL_receptor_tyrosine_kinase_ARK_JTK11_Tyro7_UFO)%5D2-IGHG1_Fc_(Fragment_constant)|rdf:type|imgt:ConstructLabels imgt:mAb_438|rdf:type|obo:NCIT_C1909 imgt:StudyProduct_5fd82fcb-b163-3742-9246-bea610f85fff|imgt:hasClinicalPhase|imgt:Phase_II imgt:Product_90e11668-63b2-3af3-a7d4-2217cda61a3f|imgt:commun_name|OMS721 imgt:StudyProduct_0aca5178-6a90-387a-8990-1deac7a84c73|imgt:hasDecision|_:Bbc746d2f081c1f71625b6b973d70f9cc imgt:StudyProduct_8a84372d-24b7-33d8-9f94-7a6a1fe6782b|rdfs:label|StudyProduct_8a84372d-24b7-33d8-9f94-7a6a1fe6782b imgt:mAb_316|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=316 imgt:Product_dc2f5235-fb7e-3f30-8b2b-21b7f0c16de7|imgt:isProducedBy|imgt:Eli_Lilly imgt:Construct_263|rdf:type|imgt:Construct imgt:VL|rdfs:label|VL imgt:_CHO-S_(Chinese_Hamster_Ovary)_cells_suspension_culture|imgt:isExpressionSystemOf|imgt:StudyProduct_1990a1c2-dc0c-3e14-80eb-7a111e2e1cc9 imgt:Product_19f07e32-1fd4-373c-81f7-b705421b88b4|imgt:comercial_name|ELOCTA™ imgt:mAb_172|imgt:centerwatch_link|http://www.centerwatch.com/drug-information/fda-approvals/drug-details.aspx?DrugID=1060 imgt:StudyProduct_f996c5d1-f2bb-3863-b37c-15596f1f9c70|rdf:type|obo:NCIT_C174271 imgt:half-G1-kappa_scFv-HEAVY-LAMBDA-h-CH2-CH3_921|obo:RO_0002162|imgt:Hum imgt:Product_233bf28c-d31a-32fb-b8ed-8ca698c7c213|rdfs:label|Product_233bf28c-d31a-32fb-b8ed-8ca698c7c213 imgt:Segment_289_1|rdf:type|imgt:Segment imgt:IgG1-kappa_366|imgt:isMabReceptorOf|imgt:mAb_366 imgt:Segment_984_1|obo:BFO_0000050|imgt:Construct_984 imgt:Product_ac4234a5-6b5e-3bf3-94f4-def2b50f16fd|imgt:hasStudyProduct|imgt:StudyProduct_58672d44-3c70-3397-842c-70fe8a5d6b98 imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_0a85bc23-6d76-3b8d-9920-b9681958b75e imgt:G1-kappa_scFv-h-CH2-CH3_1075|imgt:hasMolecularComponent|imgt:IG imgt:mAb_821|imgt:hasImgtStructureEntry|imgt:10733 imgt:Follicle-stimulating_hormone_(FSH)|rdfs:label|Follicle-stimulating hormone (FSH) imgt:Construct_1199|imgt:isConstructOf|imgt:IgG1-lambda_1199 imgt:Cancers_breast|imgt:isClinicalIndicationOf|imgt:StudyProduct_5b568fbb-a15a-3e78-9209-a8adcf9f2df4 imgt:mAb_1026|rdfs:label|mAb_1026 imgt:IgG1-lambda_1247|rdfs:comment|IgG1 - lambda obo:NCIT_C166733|rdfs:subClassOf|obo:NCIT_C1909 imgt:StudyProduct_89d67e9e-5652-3242-849d-9e5fddff6c8c|rdf:type|obo:NCIT_C174271 imgt:Construct_889|imgt:hasImgtLabel|imgt:FGF21_(fibroblast_growth_factor_21) imgt:Segment_964_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Product_11b4ca7d-b70a-3a66-b4e3-f8d1ba3e7e07|imgt:isProductOf|imgt:mAb_193 imgt:INIT-CODON|skos:definition|initiation codon 'atg' imgt:mAb_9|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=9 pubmed:7908437|dc:contributor|Hotaling T imgt:StudyProduct_8a6affb8-2186-34a2-89d8-78314af8f13c|rdfs:label|StudyProduct_8a6affb8-2186-34a2-89d8-78314af8f13c imgt:Product_4e4ab0ff-b8e5-3715-8f65-3904933d179e|imgt:commun_name|XmAb®7195 imgt:IgG1-kappa_1145|obo:RO_0002162|imgt:Hum imgt:StudyProduct_87655b3b-295a-32f2-93b1-2fe48be0a6b0|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:StudyProduct_1f4f9cd2-f2dc-33c6-b6cd-517d771b4383|imgt:isStudyProductOf|imgt:Product_4391f6b4-98b1-38e2-94d2-967326f820fe imgt:StudyProduct_03a11b7d-d669-3333-9a22-d50c3a66c16b|imgt:hasExpressionSystem|imgt:_NS0_mouse_myeloma_cells imgt:StudyProduct_d9ddb989-a3d8-3f9e-9503-fc4a15e9dd24|rdfs:label|StudyProduct_d9ddb989-a3d8-3f9e-9503-fc4a15e9dd24 imgt:Segment_673_2|obo:BFO_0000050|imgt:Construct_673 imgt:IgG1-lambda_1067|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-lambda.png imgt:Cancers_pancreatic|imgt:isClinicalIndicationOf|imgt:StudyProduct_017578ac-a956-3bd1-879e-c73a56d97c34 imgt:Fc|skos:definition|Identifies the fragment crystallisable of an IG (or antibody) obtained by papain digestion or in vitro construct. An Fc consists of the two identical hinge+CH2+CH3 heavy chain fragments linked by disulfide bridge(s). imgt:IgG4-kappa_1137|rdfs:comment|IgG4 - kappa imgt:mAb_225|imgt:hasMabReceptor|imgt:IgG1-kappa_MM_225 imgt:mAb_871|imgt:hasMabReceptor|imgt:PROTEIN_1DOMAIN-PEG_871 _:B2901adce123595f06b05e84dc8a91550|imgt:isDecisionOf|imgt:StudyProduct_5ba3245c-13cb-3e17-a35e-fe9bd9ab660b imgt:StudyProduct_d7f19d8a-4189-35e7-a73c-23e92d344117|imgt:hasClinicalPhase|imgt:Phase_II imgt:Product_657435f7-f40d-38ac-90bc-de64a58754b9|imgt:commun_name|tagraxofusp-erzs imgt:Construct_2|rdfs:label|Construct_2 imgt:Psoriasis|rdf:type|obo:NCIT_C185637 imgt:StudyProduct_5a1ad1e9-3be1-3c12-9469-e6961e41c78a|imgt:application_type|Therapeutic imgt:Clone_662|rdfs:label|Clone_662 imgt:StudyProduct_a87242af-131c-3b2d-b0ed-8bf0b1c2c07a|rdfs:label|StudyProduct_a87242af-131c-3b2d-b0ed-8bf0b1c2c07a imgt:Construct_1152|rdf:type|imgt:Construct imgt:LRR18|skos:definition|Leucine-rich repeat imgt:V-J-CLUSTER|owl:sameAs|obo:SO_0000534 imgt:mAb_949|imgt:hasMabReceptor|imgt:IgG1-lambda-kappa_949 imgt:StudyProduct_9cd1533d-275c-316f-9ca4-783d18d335e9|imgt:hasClinicalPhase|imgt:Phase_I _:Bd7a20487609b16c0f0afca71608856ad|imgt:isDecidedBy|imgt:FDA imgt:Product_918f2ade-0eb6-383e-8f05-aa3ccae100b0|rdf:type|obo:NCIT_C51980 imgt:StudyProduct_1ac52491-533f-3898-90cf-fe064bb2effa|rdfs:label|StudyProduct_1ac52491-533f-3898-90cf-fe064bb2effa imgt:Segment_600_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:StudyProduct_a6860c46-8ca9-3f3b-92a0-6aee7665ba18|rdfs:label|StudyProduct_a6860c46-8ca9-3f3b-92a0-6aee7665ba18 imgt:VH-VH%27-H-Gamma1-VL-VL%27-C-kappa_847|obo:RO_0002162|imgt:Hum imgt:Construct_890|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Product_5b1165a9-49bf-32ac-9616-2dd4a613180e|imgt:isProducedBy|imgt:Zoetis imgt:Product_9f3b70a8-1ab1-357c-82db-a284346f9860|imgt:isProducedBy|imgt:Amgen_Astellas_BioPharma_KK imgt:11559|rdfs:label|11559 imgt:V-KAPPA-L-KAPPA|rdfs:label|V-KAPPA-L-KAPPA imgt:Product_94a274de-ded8-3d8a-9d04-5df215c7d578|imgt:hasStudyProduct|imgt:StudyProduct_6ba65a28-3657-3e97-b336-766e043f01f2 _:Bf0ba6aa42c00432cb9318ec3944c64f0|imgt:isDecisionOf|imgt:StudyProduct_3c35d54e-9820-3ddb-b28e-140f4b7edbdc imgt:Construct_377|imgt:hasImgtLabel|imgt:%5BFLT1_(fms-related_tyrosine_kinase_1_vascular_endothelial_growth_factor_receptor_1_VEGFR-1_VEGFR_FLT_FRT_vascular_permeability_factor_receptor)-KDR_(kinase_insert_domain_receptor_vascular_endothelial_growth_factor_receptor_2_VEGFR2_VEGF-R2_FLK1_CD309)%5D2-IGHG1_Fc_(Fragment_constant) imgt:TNFRSF1A_(tumor_necrosis_factor_receptor_(TNFR)_superfamilly_member_1A_TNFAR_TNF-RI_TNF-R-I_p55_CD120a)_soluble_form_(TNF-binding_protein_1)|rdfs:label|TNFRSF1A (tumor necrosis factor receptor (TNFR) superfamilly member 1A, TNFAR, TNF-RI, TNF-R-I, p55, CD120a) soluble form (TNF- binding protein 1) imgt:Colitis_ulcerative_(UC)|imgt:isClinicalIndicationOf|imgt:StudyProduct_2160d844-7236-3e09-b1d3-8a9ec72b7c6a imgt:IgG1-kappa_718|imgt:hasConstruct|imgt:Construct_718 imgt:Construct_2|rdf:type|imgt:Construct imgt:mAb_847|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=847 imgt:StudyProduct_ac3f5832-c1d0-3739-9c43-3357bc50496d|imgt:isStudyProductOf|imgt:Product_f272da3d-d319-39ce-a72e-2eaf8b604878 obo:TXPO_0000039|skos:definition|'component of' is a relation between molecular components and a molecular complex. imgt:mAb_1188|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=1188 imgt:mAb_403|imgt:hasMabReceptor|imgt:IgG1-kappa_403 imgt:mAb_1095|imgt:hasProduct|imgt:Product_61d1bcf7-a2ee-33c8-8e6e-422bfd8da242 imgt:Clone_496|rdf:type|obo:NCIT_C37925 imgt:mAb_226|imgt:hasMabReceptor|imgt:IgG2b-kappa_226 imgt:Cancers_non-small_cell_lung_(NSCLC)_metastatic|imgt:isClinicalIndicationOf|imgt:StudyProduct_2cfb22ab-99b7-32af-b122-5f8019aef21e imgt:Construct_175|imgt:isConstructOf|imgt:IgG1-kappa_175 imgt:StudyProduct_f48398da-a782-3ed1-bdd3-11e613ae9b5a|rdfs:label|StudyProduct_f48398da-a782-3ed1-bdd3-11e613ae9b5a imgt:Pulmonary_arterial_hypertension_(PAH)|imgt:clinical_domain|Pulmonary, Respiratory diseases imgt:Ebola_virus_infection|imgt:isClinicalIndicationOf|imgt:StudyProduct_b20304f6-bf94-3f03-a498-f9ac5973a58e imgt:TR-Group|rdfs:label|TR-Group imgt:isBibliographicReferenceOf|rdfs:domain|bibo:Article imgt:Melanoma_metastatic|imgt:isClinicalIndicationOf|imgt:StudyProduct_22c6ada5-2eee-37e2-9148-181ded19c630 imgt:Segment_128_1|imgt:has_rank|1 imgt:BETA-ALPHA1_987|http://semanticscience.org/resource/SIO_000291|imgt:MAGEA10 imgt:myosin,_cardiac|skos:definition|myosin, cardiac imgt:StudyProduct_fd21280d-65a7-3a34-bf82-08cc054f9a32|imgt:application_type|Therapeutic imgt:StudyProduct_a87c7ab7-0aba-3c60-b0ce-34686ba730c0|imgt:hasClinicalPhase|imgt:Phase_M imgt:nucleic_acid|skos:definition|Identifies a sequence made of nucleotides (A, U or T, C, G). imgt:Segment_625_1|rdfs:label|Segment_625_1 imgt:isConstructOf|rdfs:label|isConstructOf imgt:StudyProduct_8b843fa5-61a4-3e1c-8856-51d838be7868|imgt:development_technology| Dyax human antibody phage display library imgt:StudyProduct_93fa8b38-cc21-3fb3-a3d1-c26a79942eac|rdf:type|obo:NCIT_C174271 obo:NCIT_C152149|rdfs:subClassOf|obo:NCIT_C1909 imgt:StudyProduct_ba5846bc-9689-3122-b3c1-045007a7f673|imgt:application_type|Therapeutic imgt:mAb_764|imgt:inn_proposed_list|117 (2017) imgt:Product_80c5a255-5aa4-3782-9556-7a0618ee7c39|rdfs:label|Product_80c5a255-5aa4-3782-9556-7a0618ee7c39 imgt:StudyProduct_2885244f-5d5a-36a6-b367-fb9982d41711|imgt:hasClinicalPhase|imgt:Phase_I imgt:Viragen_Inc|rdfs:comment|Plantation , USA imgt:mAb_583|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=583 _:Bd4eca48c0e85a45426d335e3efdf6404|dc:date|2017-08-16 imgt:Product_d1ff3524-abf9-3a7a-93d3-8b514c80da83|imgt:hasStudyProduct|imgt:StudyProduct_ea630399-3539-32a6-b42c-18836fbb512f imgt:mAb_485|imgt:hasProduct|imgt:Product_748cfcf2-49c1-36df-8de9-d7e91136c389 imgt:StudyProduct_9bce41bd-96a7-3675-8cd2-30317439f912|imgt:hasDecision|_:Be2a6c2341f225bd603e308a14f8df42d imgt:FPIA_%5BPROTEIN_VLIKE%5D2-FC_212|http://semanticscience.org/resource/SIO_000291|imgt:CD86 imgt:Systemic_lupus_erythematosus_(SLE)|imgt:isClinicalIndicationOf|imgt:StudyProduct_e884ecd3-d0f3-3f39-9a5c-93a00dd8ceef imgt:National_Institute_of_Allergy_and_Infectious_Diseases_(NIAID)|imgt:produces|imgt:Product_b53d5313-835d-3d6b-8fb3-a4650e3a36ef imgt:Product_25623bb4-dbeb-3eb1-8289-b2926b511903|rdfs:label|Product_25623bb4-dbeb-3eb1-8289-b2926b511903 imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_9f557969-ab56-3ded-bc53-cb04c365c2b3 imgt:mAb_363|imgt:clinical_trials|20 studies found, 2 recruiting _:B2940f36c870e7d879b4924b442c11232|rdf:type|obo:NCIT_C53285 imgt:11807|rdfs:label|11807 imgt:Product_0b512c25-d599-3b22-a756-c5c415e669fc|imgt:commun_name|MDX-018 imgt:StudyProduct_22c6ada5-2eee-37e2-9148-181ded19c630|imgt:hasClinicalPhase|imgt:Phase_II imgt:Segment_57_1|obo:BFO_0000050|imgt:Construct_57 pubmed:12359774|dc:title|Mice lacking the EDB segment of fibronectin develop normally but exhibit reduced cell growth and fibronectin matrix assembly in vitro. imgt:9698|imgt:isImgtStructureEntryOf|imgt:mAb_462 imgt:Poison_ivy|imgt:isClinicalIndicationOf|imgt:StudyProduct_bf390145-1da6-3243-8c8b-6e1b025d646b imgt:IgG1-kappa_799|obo:RO_0002162|imgt:Homsap imgt:StudyProduct_94244cbd-18b6-3fc6-b55a-43ecf1366510|imgt:hasClinicalPhase|imgt:Phase_II imgt:PROTEIN_1DOMAIN_1052|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/PROTEIN_1DOMAIN.png imgt:IgG1-kappa_763|imgt:hasConstruct|imgt:Construct_763 imgt:Neuromyelitis_optica_(NMO)|imgt:isClinicalIndicationOf|imgt:StudyProduct_6b82f34f-3edd-3161-901d-a48e9eb3c856 imgt:Product_4384026e-ba8b-350f-b05f-d196a99c173c|imgt:commun_name|IBI-306 imgt:Product_6921438e-7c6b-3e42-bd7f-0e3bc47d6848|imgt:commun_name|ESBA-105 imgt:Product_eee3061f-bf14-3e3d-9646-c7c2fe6d3166|imgt:commun_name|520C9XH22 imgt:CH3|rdf:type|imgt:ChainLabels imgt:Product_6d00b4b8-121c-3156-854d-ae9f08aba45a|imgt:isProducedBy|imgt:Akeso_Biopharma_Inc imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_4f65251e-aa1e-3f5b-989f-59474db4838b imgt:mAb_303|rdf:type|imgt:INN imgt:Product_7c5b4231-8351-3ed9-ba1d-8c48699ed506|imgt:hasStudyProduct|imgt:StudyProduct_3b1ae0f9-fbe1-3c51-8b11-217af9857a4b imgt:Thyroid_eye_disease_(TED)|rdf:type|obo:NCIT_C185637 imgt:mAb_444|imgt:imgt_note| HepeX-C is currently containing a single antibody (company web site 19/08/12) which is AB68 (FDA). XTL Biopharmaceuticals Ltd. is planning to use AB68 in combination with AB65 (XTL-6865). In the literature, HepeX-C is used for AB68 only, or for the combination of AB68 and AB65. imgt:Product_60d67764-c42e-3595-b0ea-20f088fd5134|rdf:type|obo:NCIT_C51980 imgt:Product_78514588-e4f5-3f0c-a094-1bdb7d5a89fd|rdfs:label|Product_78514588-e4f5-3f0c-a094-1bdb7d5a89fd imgt:Product_8b707060-aa4c-3416-b720-0b2304c54b88|imgt:isProducedBy|imgt:AstraZeneca imgt:Obesity|imgt:clinical_domain|Endocrinology imgt:MET|imgt:isTargetOf|imgt:IgG1-kappa_937 imgt:Product_c9b09440-3c97-37f9-a7a3-a051cfd3499c|rdfs:label|Product_c9b09440-3c97-37f9-a7a3-a051cfd3499c imgt:Product_8bc22827-09a3-3eb0-9e53-3f97c122310c|imgt:isProductOf|imgt:mAb_1265 imgt:IgG1-kappa_466|imgt:isMabReceptorOf|imgt:mAb_466 imgt:MAbReceptor_23|rdfs:label|MAbReceptor_23 imgt:mAb_649|rdfs:label|mAb_649 imgt:Construct_360|obo:BFO_0000051|imgt:Segment_360_1 imgt:(VH-CH2-CH3)2_S_1220|http://semanticscience.org/resource/SIO_000291|imgt:Severe_acute_respiratory_syndrome_coronavirus_(SARS-CoV) imgt:Construct_463|imgt:isConstructOf|imgt:IgG1-kappa_463 imgt:StudyProduct_d1b2118d-6cba-3ecc-8e0d-f3d258cc0229|imgt:application_type|Therapeutic imgt:EUSA_Pharma|rdf:type|obo:NCIT_C54131 _:B6c0e3dfb428e18cb60a1ed48a1479f8f|dc:date|2016-08-16 imgt:Giant_cell_arteritis|rdf:type|obo:NCIT_C185637 imgt:CD44|rdfs:label|CD44 obo:NCIT_C170022|rdfs:subClassOf|obo:NCIT_C1909 imgt:5ID0|imgt:isImgtStructureEntryOf|imgt:mAb_151 imgt:Segment_765_1|rdf:type|imgt:Segment imgt:StudyProduct_05ddb4d2-a6fb-3832-9fe2-3592ea8df038|imgt:hasClinicalIndication|imgt:Chronic_lymphocytic_leukemia_(CLL) _:Bd9f52fce09c403f141619631fc6a8dec|rdf:type|obo:NCIT_C53285 imgt:mAb_1177|imgt:hasProduct|imgt:Product_be7fe1ac-60ec-3e93-a36a-4383c0cb79ad imgt:Segment_637_1|imgt:segment_detail|*a (C38) 22-187 imgt:Pigmented_villonodular_synovitis_(PVNS)|imgt:clinical_domain|Immunology imgt:mAb_539|imgt:hasImgtStructureEntry|imgt:10068 imgt:Segment_756_1|imgt:has_rank|1 imgt:ABL1|rdf:type|imgt:ChainLabels imgt:Segment_836_1|obo:RO_0002162|imgt:Homsap imgt:StudyProduct_24927660-46be-3320-af9b-3889951ff778|imgt:development_technology| POTELLIGENT® technology (afucosylation) imgt:IgG2c_Lambda|imgt:isDefinedBy|imgt:IG-Heavy-Gamma-2-c-IGHG2C imgt:StudyProduct_e54e09d6-1e7f-3c2f-8ed7-3945b3aee605|imgt:hasClinicalPhase|imgt:Phase_II imgt:scFv-kappa-heavy-IGHG4_h_(CO)-CD28_(TM)-TNFRSF9_(CY)_CD247-TEApep-EGFRt_874|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/scFv-kappa-heavy-IGHG4%20h%20(CO)-CD28%20(TM)-TNFRSF9%20(CY)%20CD247-TEApep-EGFRt.png imgt:Product_b2047389-8f1a-3406-9333-efe3ec11daac|imgt:isProductOf|imgt:mAb_635 imgt:StudyProduct_df2b1eee-0658-3294-a5a9-6de278413282|imgt:isStudyProductOf|imgt:Product_6bc1d7d7-3572-3445-908f-a32d9aa7218d imgt:%5BIL15RA_(interleukin_15_receptor_subunit_alpha_CD215_IL-15RA)%5D2-IGHG1_Fc_(Fragment_constant)|imgt:construction_detail|Fusion - [IL15RA (interleukin 15 receptor subunit alpha, CD215, IL-15RA)]2 - IGHG1 Fc (Fragment constant) imgt:skeletal-related_events_in_patients_with_bone_metastases_from_solid_tumors|rdf:type|obo:NCIT_C185637 imgt:Product_65d1338b-2af9-3814-ae94-b94de9579065|rdf:type|obo:NCIT_C51980 imgt:CH3-IGHG1|rdf:type|imgt:ChainLabels imgt:Segment_612_3|imgt:hasImgtLabel|imgt:IGHG4 imgt:Zaire_Ebola_virus|skos:definition|Zaire Ebola virus (EBOV) imgt:StudyProduct_71e46760-7799-3358-acaf-2ab6daddc448|imgt:hasClinicalIndication|imgt:Cancers_pancreatic imgt:StudyProduct_8c1b462f-c962-344a-9c3d-afcb903712e3|imgt:hasClinicalPhase|imgt:Phase_II imgt:mAb_1213|imgt:hasMabReceptor|imgt:IgG1-kappa_1213 imgt:StudyProduct_5e71b1dd-9ab2-3249-a5d9-508cd9d5ced1|imgt:hasClinicalPhase|imgt:Phase_M imgt:mAb_1209|imgt:hasOriginClone|imgt:Clone_1209 imgt:StudyProduct_15a0a4ce-6b3c-34bc-9df1-8eb1c35bc123|imgt:hasClinicalPhase|imgt:Phase_I/II imgt:Construct_679|rdf:type|imgt:Construct obo:NCIT_C147523|rdfs:subClassOf|obo:NCIT_C1909 _:B9b176b31cfffc9584abd4d6791af9041|dc:date|2016-09-23 imgt:Product_8f2b525d-90b5-3eb3-92db-11b02305df48|imgt:commun_name|AL-901 _:Ba34795dacdadb7f86769086bb6930fb3|rdf:type|obo:NCIT_C53285 imgt:Segment_665_1|rdfs:label|Segment_665_1 imgt:7105|rdf:type|obo:NCIT_C25402 imgt:mAb_238|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=238 imgt:Construct_252|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Product_612d4d3f-ba9e-32f0-8c9e-b0f617c1e263|rdf:type|obo:NCIT_C51980 _:Ba9ef72b9d6c9661d4a7f82bd9aee9a1a|imgt:isDecisionOf|imgt:StudyProduct_e18346b4-c502-3a24-9514-3f9ecb2d5d74 imgt:Segment_615_1|rdf:type|imgt:Segment imgt:Product_bd699630-ef8f-32d5-a803-0638e592679a|rdf:type|obo:NCIT_C51980 imgt:Autoimmune_diseases|imgt:isClinicalIndicationOf|imgt:StudyProduct_cd4ac466-54bc-3572-923e-d007db93a427 imgt:StudyProduct_9a60d879-ca3e-3b3e-a03f-a1228692b419|imgt:hasDecision|_:Ba0b78f64f394eeb0b456b26c452b6307 imgt:IgG1-kappa_1178|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:StudyProduct_c1c79f94-82b3-3634-af44-93c5fd798a7d|imgt:hasClinicalPhase|imgt:Phase_III imgt:Construct_70|rdfs:label|Construct_70 imgt:productive|rdfs:label|productive imgt:StudyProduct_f0c8977d-e83e-3a42-b1ae-a6e1a47ee5c2|imgt:hasClinicalPhase|imgt:Phase_I imgt:Product_c35429a8-2c73-3c01-bfd2-200427b3e81f|imgt:isProductOf|imgt:mAb_750 imgt:mAb_327|rdf:type|imgt:INN imgt:Product_f13441d6-24fa-3bbd-8cf9-c42aef37f1b1|rdf:type|obo:NCIT_C51980 imgt:11023|rdf:type|obo:NCIT_C25402 imgt:3C-LIKE|rdf:type|imgt:RPILabel imgt:9123|imgt:isImgtStructureEntryOf|imgt:mAb_302 imgt:Product_2ee82a43-7e76-390b-aa4f-6d5f3dc3cbde|rdf:type|obo:NCIT_C51980 imgt:Segment_1284_1|obo:BFO_0000050|imgt:Construct_1284 imgt:mAb_354|imgt:inn_proposed_list|103 (2010) imgt:Esophagitis_eosinophilic|imgt:isClinicalIndicationOf|imgt:StudyProduct_7c02ae71-57b5-3268-83a4-424069d7d5c9 imgt:Severe_acute_respiratory_syndrome_coronavirus_2_(SARS-CoV-2)|imgt:isTargetOf|imgt:IgG4-kappa_1218 imgt:StudyProduct_5b2accd7-abb8-3404-b64e-41d8677041ff|imgt:hasClinicalIndication|imgt:Glioblastoma imgt:11559|imgt:isImgtStructureEntryOf|imgt:mAb_1125 pubmed:17240489|rdfs:label|PMID_17240489 imgt:(VH-CH2-CH3)2_S_934|imgt:isMabReceptorOf|imgt:mAb_934 imgt:mAb_719|imgt:hasProduct|imgt:Product_e4e1cd24-03d8-3522-80e7-29683d204cec imgt:Adenocarcinoma|imgt:isClinicalIndicationOf|imgt:StudyProduct_c081fa56-a921-36df-afc7-4fda57fffc19 imgt:Product_f3aa031e-8b97-3744-9e8b-c4503f8ec1c5|imgt:isProducedBy|imgt:Daiichi_Sankyo_Inc imgt:StudyProduct_bdb855d2-1971-3748-84d7-811750a7c365|imgt:hasClinicalIndication|imgt:Adenocarcinoma_gastric imgt:StudyProduct_30d64f00-34cf-3fd4-ab13-6ba911ba69eb|imgt:hasClinicalIndication|imgt:Anemia_autoimmune_hemolytic_(AIHA) imgt:Product_e0278568-febe-37ab-bbd2-9027ac7db7e5|rdf:type|obo:NCIT_C51980 imgt:FN1-2|rdfs:label|FN1-2 imgt:Product_f585c3aa-a22a-3afb-9114-31450ab8bf8e|imgt:isProductOf|imgt:mAb_70 imgt:mAb_495|imgt:inn_recommended_list|73 (2015) obo:SO_0000488|rdf:type|owl:Class imgt:Beta_thalassemia_(Cooley’s_anemia)|imgt:isClinicalIndicationOf|imgt:StudyProduct_8ce86eff-8b49-3cde-a769-b0f3f57d671f obo:NCIT_C117241|rdfs:subClassOf|obo:NCIT_C1909 imgt:IG-Light-Iota-2-IGI2|rdfs:label|IG-Light-Iota-2-IGI2 imgt:Construct_754|rdfs:label|Construct_754 imgt:Cancers_prostate|imgt:isClinicalIndicationOf|imgt:StudyProduct_337bc546-61ff-3922-a9e1-4aa327357535 imgt:Segment_696_1|rdfs:label|Segment_696_1 imgt:StudyProduct_c51e3bd8-108d-39e1-b6c7-e52a7b327339|rdfs:label|StudyProduct_c51e3bd8-108d-39e1-b6c7-e52a7b327339 imgt:StudyProduct_e431bdd5-d4bb-3422-a165-dec80514e81c|imgt:hasClinicalPhase|imgt:Phase_I imgt:mAb_781|rdf:type|imgt:INN imgt:Segment_158_1|rdfs:label|Segment_158_1 imgt:IgG1-kappa_175|rdfs:label|IgG1-kappa_175 imgt:Osteoarthritis_(OA)|imgt:isClinicalIndicationOf|imgt:StudyProduct_a17be910-448c-39cd-9135-1e69cc88ffe0 imgt:Anthrax_inhalation|imgt:isClinicalIndicationOf|imgt:StudyProduct_a5efddc8-bf21-3fc9-987f-11778f5c8a4b imgt:Construct_308|imgt:isConstructOf|imgt:IgG3-kappa_308 imgt:Triumvira_Immunologics|imgt:produces|imgt:Product_21b92b88-2674-3575-8a48-80255e478298 imgt:mAb_718|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=718 imgt:Immediate-type_hypersensitivities|imgt:clinical_domain|Immunology _:B2fad28b7d981b2ffea2cd065c3dc4a85|dc:date|2006-10-03 imgt:TFPI|rdf:type|obo:NCIT_C25702 imgt:H-GAMMA-2|rdf:type|imgt:ChainLabels imgt:9368|rdf:type|obo:NCIT_C25402 _:Ba166c0b97e46582cfe441bceee6c3091|imgt:hasDesignation|imgt:Orphan_drug imgt:8963|imgt:isImgtStructureEntryOf|imgt:mAb_246 imgt:Product_140c503b-9c60-33d9-ade4-ebf498c21611|imgt:hasStudyProduct|imgt:StudyProduct_f8ea0962-96ab-3f9b-80d2-b5d260255e59 imgt:des-38-proline_exendin-4|rdfs:label|des-38-proline exendin-4 imgt:Segment_258_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:mAb_807|imgt:inn_name|leronlimab imgt:Product_823dd5e7-e3e3-3909-90c0-6b381ca01691|imgt:commun_name|SCB-313 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imgt:IgG2b-kappa_503|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG2b-kappa.png imgt:mAb_449|imgt:hasProduct|imgt:Product_c545816c-e16f-3035-a4bc-97ae27507d0d imgt:mAb_980|imgt:inn_number|11068 imgt:IGF2|skos:definition|IGF2 (insulin-like growth factor 2, somatomedin A) imgt:IgG1-kappa-3cys-drug_712|imgt:conjugated_with| monomethyl auristatin E (MMAE) imgt:IgG1-kappa_1222|imgt:hasConstruct|imgt:Construct_1222 imgt:mAb_422|imgt:hasImgtStructureEntry|imgt:9653 imgt:IgG4-kappa_533|imgt:hasConstruct|imgt:Construct_533 imgt:Product_720d45e6-dec4-374b-bf22-5df164a8eed9|imgt:commun_name|SAR-650984 imgt:Product_2ea8bfa6-04c4-3f93-82a6-8c152fb4cc3b|imgt:commun_name|ABT-555 imgt:IgG2-kappa_102|http://semanticscience.org/resource/SIO_000291|imgt:IL1B imgt:mAb_1281|imgt:hasImgtStructureEntry|imgt:11904 _:Ba4b746cb54b0c805136ac1cdd89590d1|rdf:type|obo:NCIT_C53285 imgt:Product_ed1edad0-0dff-3bc0-86df-b902af890c2a|imgt:hasStudyProduct|imgt:StudyProduct_e71f82cd-4d55-3f0e-bac1-74d5fa41efb3 imgt:Canine_parvovirus|rdf:type|obo:NCIT_C185637 pubmed:27310493|dc:contributor|Penney M imgt:Product_3d3847b0-2ca8-3154-aa57-18221948bd0d|rdfs:label|Product_3d3847b0-2ca8-3154-aa57-18221948bd0d imgt:IgG4-kappa-protein_1019|imgt:isMabReceptorOf|imgt:mAb_1019 imgt:Peanut_allergy_(severe)|imgt:isClinicalIndicationOf|imgt:StudyProduct_52f7694c-67da-3b01-bf23-037468a1348b imgt:Segment_980_1|imgt:hasImgtLabel|imgt:CSF3 imgt:PACT_Pharma_Inc|imgt:produces|imgt:Product_a1b25bb3-97f5-363a-8463-339103288cd8 imgt:Product_042c8435-6492-3cdb-a685-d17d13c06937|rdf:type|obo:NCIT_C51980 imgt:NantCell_Inc|rdfs:comment|Culver City , USA imgt:Product_48ae33c8-07c7-35fd-809f-51816c731b98|imgt:commun_name|LY-3303560 imgt:mAb_940|imgt:inn_recommended_list|83 (2020) imgt:MAbReceptor_880|rdfs:label|MAbReceptor_880 imgt:IgG1-kappa_175|imgt:isMabReceptorOf|imgt:mAb_175 imgt:IgG4-kappa_449|rdfs:label|IgG4-kappa_449 imgt:Tumors|imgt:clinical_domain|Oncology imgt:StudyProduct_f9931cb1-61ae-324e-a2be-bf35bad4a04b|rdf:type|obo:NCIT_C174271 imgt:Product_375c2e4e-3527-3271-b018-448b9ee8aba7|imgt:isProductOf|imgt:mAb_968 imgt:StudyProduct_94d0a7b8-71f4-33c7-becb-5219629da21d|imgt:hasClinicalPhase|imgt:Phase_II imgt:StudyProduct_1d9f9af6-bbf0-3596-ae4e-b1d01b3bc677|imgt:hasClinicalPhase|imgt:Phase_M imgt:_CHOK1SV_(expresses_glutamine_synthetase_(GS)_endogenously)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_96f46e52-e9a8-3eeb-8b87-64e1abc367fe imgt:9537|rdfs:label|9537 imgt:StudyProduct_f076d291-a18a-317a-9d91-2653f3cde677|rdf:type|obo:NCIT_C174271 imgt:Clone_955|imgt:clone_name|LA532-5H10 imgt:Construct_431|rdfs:label|Construct_431 imgt:StudyProduct_cfcfdb97-fa02-3890-8459-d5defed66faa|imgt:hasDecision|_:Ba3393e61976228e54bd893ad3b7ab727 imgt:mAb_1263|imgt:hasMabReceptor|imgt:IgG4-kappa_1263 imgt:StudyProduct_c3e35807-0778-3670-8878-2c817a51e8c1|imgt:hasClinicalIndication|imgt:Cancers_colorectal_(CRC) imgt:F7|skos:definition|F7 coagulation factor VII imgt:Segment_419_1|obo:BFO_0000050|imgt:Construct_419 imgt:Product_5476fc80-3a08-32aa-9c6a-142caa48e5ed|imgt:hasStudyProduct|imgt:StudyProduct_d95be201-a49e-36b7-b0b9-34083fda5ea2 imgt:mAb_419|imgt:hasProduct|imgt:Product_80543f95-22b7-3761-a574-ef4df0802d70 imgt:Diabetic_macular_edema|imgt:isClinicalIndicationOf|imgt:StudyProduct_5c6ab355-38c2-30a4-9c5b-2b557d0ded7e imgt:C-GENE|imgt:imgt_link|http://www.imgt.org/IMGTScientificChart/SequenceDescription/displayimage.php?id=6 imgt:mAb_88|imgt:inn_number|8227 imgt:mAb_815|rdf:type|obo:NCIT_C124134 imgt:IgG1-kappa_420|imgt:hasMolecularComponent|imgt:IG imgt:L-LAMBDA-6|rdfs:label|L-LAMBDA-6 imgt:StudyProduct_5ff62102-e848-3f73-a032-36953e1cfc52|imgt:isStudyProductOf|imgt:Product_fe170d32-2e79-37f8-b44b-a495e80a927a imgt:IgG4-kappa_1137|imgt:hasMolecularComponent|imgt:IG imgt:FPIA_%5BPROTEIN_VLIKE%5D2-FC_215|rdfs:comment|FPIA_[PROTEIN_VLIKE]2-FC imgt:mAb_520|imgt:imgt_note| Biogen (Cambridge MA USA) and IDEC Pharmaceuticals (San Diego USA CA) merged in 2003 creating Biogen Idec. Biogen Idec has changed its name to Biogen (23 March 2015). IMGT note: Monomeric Fc fusion (monovalent for the therapeutic protein while retaining a bivalent Fc) was developed by Syntonix Pharmaceuticals, acquired by Biogen Idec in 2007. Monomeric Fc fusion (monovalent for the therapeutic protein while retaining a bivalent Fc) was developed by Syntonix Pharmaceuticals, acquired by Biogen Idec in 2007. MOA: Factor substitute imgt:IgG2-lambda_992|http://semanticscience.org/resource/SIO_000291|imgt:CD3E imgt:IgG2-nd|rdf:type|imgt:ConstructLabels imgt:11465|imgt:isImgtStructureEntryOf|imgt:mAb_1084 imgt:IgG1-lambda_189|imgt:hasMolecularComponent|imgt:IG imgt:11465|rdfs:label|11465 imgt:Product_5eb41d03-904f-31e2-99cf-e8e07792e97b|imgt:commun_name|ALD-518 imgt:StudyProduct_bcd14e53-bdb2-3301-8a94-47c1c744e4a4|imgt:hasDecision|_:Be33473896e67274b3947140c8b0bc093 imgt:Giant_cell_arteritis|imgt:isClinicalIndicationOf|imgt:StudyProduct_380786ae-bc71-3980-ad18-e13fdcc0b325 imgt:FPIA_%5BPROTEIN-PROTEIN-PROTEIN%5D2-FC_377|obo:RO_0002162|imgt:Homsap imgt:StudyProduct_a9f55676-d321-39a7-8686-9ee4acfc0ef9|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_ddc3e164-711b-37f8-963d-7e7f4ccb53a5|imgt:hasClinicalIndication|imgt:Solid_tumors _:B387ac121563f930c1c364117366da962|imgt:isDecisionOf|imgt:StudyProduct_ef68c918-bdad-375e-8496-050eece2bd08 imgt:Product_a7a3a8e3-962a-3cab-8c20-baf4baa0f755|imgt:isProductOf|imgt:mAb_616 imgt:ixifi™|rdfs:label|IXIFI™ imgt:8568|rdf:type|obo:NCIT_C25402 imgt:Product_37ffad37-3840-3cfc-a777-f523c62fcb62|imgt:commun_name|BNT-312 imgt:StudyProduct_eb7dc2d9-89c1-3e59-9dd6-bbd47b396981|imgt:isStudyProductOf|imgt:Product_c5f39918-e8ab-30c6-887b-1fb87d6ca127 imgt:Seattle_genetics_Inc|imgt:produces|imgt:Product_d75165ab-4ffe-3b58-a051-77afd4e2bb75 imgt:Acute_myocardial_infarction|imgt:isClinicalIndicationOf|imgt:StudyProduct_b93864b8-b15d-3309-8103-c041e9e8e8c9 imgt:IgG4-kappa_918|imgt:hasMolecularComponent|imgt:IG imgt:Segment_967_1|imgt:has_rank|1 imgt:IgG4-kappa_533|imgt:hasMolecularComponent|imgt:IG imgt:Construct_662|imgt:isConstructOf|imgt:IgG1-kappa_662 imgt:mAb_817|rdf:type|obo:NCIT_C171828 imgt:MET|obo:RO_0002162|imgt:Homsap imgt:IgG1-nd_444|imgt:isMabReceptorOf|imgt:mAb_444 imgt:CD86|imgt:isTargetOf|imgt:FPIA_%5BPROTEIN_VLIKE%5D2-1S-FC_247 imgt:11146|imgt:isImgtStructureEntryOf|imgt:mAb_958 imgt:StudyProduct_43a6c6d3-3ed9-3a0a-9cab-c99d5c497359|imgt:development_technology| Dyax human antibody phage display library imgt:Construct_629|rdf:type|imgt:Construct _:Bba3614d0fab02906dcb369ce0a03a7b9|imgt:isDecisionOf|imgt:StudyProduct_08a430cc-2e25-3c2f-a8b8-423cb63faac7 imgt:StudyProduct_b08c3015-33c4-345c-9a3b-608affccfe49|imgt:development_technology| Dyax human antibody phage display library imgt:IL10RB|imgt:isTargetOf|imgt:FPIA_%5BPROTEIN%5D2-FC_1043 imgt:IgG4-kappa_78|http://semanticscience.org/resource/SIO_000291|imgt:CD4 imgt:mAb_228|imgt:inn_name|camidanlumab imgt:CD3E|imgt:isTargetOf|imgt:scFv-scFv-scFc_kappa-lambda_1074 imgt:IgG1-lambda2|rdf:type|imgt:ConstructLabels imgt:IgM_Kappa_J-chain|imgt:isDefinedBy|imgt:IG-Heavy-Mu-IGHM imgt:Product_42e77b63-637a-3381-a8be-5f8318cc28a2|imgt:isProductOf|imgt:mAb_628 imgt:IgG1-kappa-2cys-drug_815|imgt:conjugated_with| monomethyl auristatin E (MMAE) imgt:Segment_715_1|obo:BFO_0000050|imgt:Construct_715 imgt:StudyProduct_cb666bf7-76ef-38f3-ba4f-2d867501e03e|imgt:hasClinicalPhase|imgt:Phase_II imgt:Product_3240bd63-d353-315d-9029-d61ff35ab692|imgt:hasStudyProduct|imgt:StudyProduct_da7b0ba2-8773-30c0-9a09-cf9dd7a94e71 imgt:Transplantation|rdfs:label|Transplantation imgt:mAb_539|imgt:hasProduct|imgt:Product_e6cefd95-eb16-32aa-adc9-813b1166be33 imgt:mAb_1172|imgt:inn_recommended_list|87 (2022) imgt:TR-Alpha-TRA|rdf:type|imgt:ReceptorLevelChainType imgt:Product_bcb21f4c-72e4-3022-a04c-c911e4e8a2d0|rdf:type|obo:NCIT_C51980 imgt:VH-CH1-CH2-CH3|skos:definition|Chain or receptor comprising VH-CH1-CH2-CH3 imgt:FC-ALPHA|rdf:type|imgt:IGProteolyticFragmentLabel imgt:StudyProduct_bb050277-acb5-3c72-ad0f-0f86e2867b02|rdfs:label|StudyProduct_bb050277-acb5-3c72-ad0f-0f86e2867b02 imgt:IgG2_Kappa|rdf:type|imgt:ReceptorType imgt:FAB-GAMMA-3_KAPPA|rdfs:label|FAB-GAMMA-3_KAPPA imgt:Clone_522|rdf:type|obo:NCIT_C37925 imgt:_CHO_(Chinese_Hamster_Ovary)_MTX_(methotrexate_resistant)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_52aec5c4-8017-318a-be45-cf1c1533a0fa imgt:Segment_1178_1|rdfs:label|Segment_1178_1 imgt:IgG1-kappa-4lys-drug_1065|imgt:hasMolecularComponent|imgt:IG imgt:Teijin_Ltd|imgt:produces|imgt:Product_f36504b9-7a54-3056-b3e8-26781525dfe1 imgt:mAb_1287|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=1287 imgt:StudyProduct_3938e3bf-5caa-3bde-a890-4e5001b4a0ae|imgt:development_technology| No N-glycosylation sites CH2 N84.4A Antibody phage display library imgt:Segment_521_2|rdfs:label|Segment_521_2 imgt:FC-ALPHA|imgt:describes|imgt:Fc-Alpha imgt:IgG1-nd_190|obo:RO_0002162|imgt:Homsap imgt:StudyProduct_7e747b42-756f-362e-bf69-d6b3856a8ba4|imgt:development_technology| Human hybridoma imgt:Product_f4071a62-44ea-3bb4-9bb6-5c68735042f7|imgt:hasStudyProduct|imgt:StudyProduct_155a9067-b940-3fed-b7cc-27c6460913bb imgt:Product_25709140-bbc7-373c-9a44-2be9be3d8e9d|imgt:hasStudyProduct|imgt:StudyProduct_233122d6-a975-377b-8d6a-a86d5c73aa72 imgt:IgG1-kappa_1204|imgt:hasMolecularComponent|imgt:IG _:B6f879dbd963a642f6949c2d13d2e5a1c|imgt:isDecisionOf|imgt:StudyProduct_aed1894e-85c8-30fe-9928-aa2ec48a80f4 imgt:IgG4-kappa_562|rdfs:comment|IgG4 - kappa imgt:mAb_1083|rdfs:label|mAb_1083 imgt:Construct_849|imgt:hasImgtLabel|imgt:IgG4-kappa imgt:Clone_1202|rdf:type|obo:NCIT_C37925 imgt:Construct_1270|imgt:isConstructOf|imgt:IgG1-kappa_1270 imgt:mAb_1014|rdfs:label|mAb_1014 imgt:Segment_300_1|imgt:has_rank|1 imgt:StudyProduct_443d9d1d-8da9-3091-b330-0402f6b180e3|imgt:isStudyProductOf|imgt:Product_720d45e6-dec4-374b-bf22-5df164a8eed9 imgt:Product_475ec8af-d4f7-3fe4-82b1-ba8b12a3c69d|imgt:isProducedBy|imgt:MedImmune pubmed:25146490|dc:date|2015 imgt:FAB-GAMMA-1_V-LAMBDA-C-KAPPA|rdfs:label|FAB-GAMMA-1_V-LAMBDA-C-KAPPA imgt:mAb_227|imgt:hasProduct|imgt:Product_9186186a-7147-3fe7-bbf9-599dbe1368ab imgt:StudyProduct_840038d5-17cf-3969-89f8-b758355d4583|imgt:isStudyProductOf|imgt:Product_3629d62a-835e-3451-9627-989a060b21f4 imgt:9932|rdfs:label|9932 _:B05f0df4244db1e8303df38a9ab9f1e13|rdf:type|obo:NCIT_C53285 imgt:StudyProduct_642dc84c-f9a5-3a28-8ee9-901f18a963f6|rdf:type|obo:NCIT_C174271 imgt:mAb_567|imgt:inn_recommended_list|75 (2016) imgt:11258|imgt:isImgtStructureEntryOf|imgt:mAb_1003 imgt:Construct_331|imgt:hasImgtLabel|imgt:%5BACVR2A_(activin_A_receptor_type_2A_ActR-II_ActRIIA)%5D2-IGHG1_Fc_(Fragment_constant) imgt:Segment_102_1|obo:BFO_0000050|imgt:Construct_102 imgt:Construct_958|obo:BFO_0000051|imgt:Segment_958_1 imgt:Clone_186|rdfs:label|Clone_186 imgt:Construct_1270|rdf:type|imgt:Construct imgt:Construct_729|obo:BFO_0000051|imgt:Segment_729_1 imgt:StudyProduct_ad128f55-9f9a-39d6-8b42-149263c92261|imgt:hasExpressionSystem|imgt:_Sp2/0_mouse_hybridoma_cells imgt:Carcinoma_bladder_cancer_advanced_or_metastatic_urothelial_cancers|imgt:isClinicalIndicationOf|imgt:StudyProduct_d27f3450-4dac-3002-9b81-f849b03174fa imgt:mAb_60|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=60 imgt:Segment_604_1|rdf:type|imgt:Segment imgt:StudyProduct_56910023-f831-3f31-a66c-2f627228bcc5|imgt:hasClinicalPhase|imgt:Phase_II imgt:IgG1-kappa_1214|rdfs:label|IgG1-kappa_1214 imgt:StudyProduct_8deb92d7-c9b3-3497-aa96-ca650a98e7d1|imgt:hasDecision|_:B954606fe400c658bc3ceefa68ebffff8 _:Bf3c9223a34ee5c5807afba62cd9f7844|dc:date|2017-02-13 imgt:IgG1-kappa_940|rdf:type|imgt:MAbReceptor imgt:Construct_539|imgt:isConstructOf|imgt:IgG1-kappa_539 imgt:IgG1-lambda-kappa_949|http://semanticscience.org/resource/SIO_000291|imgt:MS4A1 imgt:Construct_233|rdf:type|imgt:Construct imgt:Product_e9725593-72db-3005-b841-06e3fc3b71a1|imgt:isProducedBy|imgt:Cambridge_Antibody_Technology imgt:StudyProduct_6467b730-1f75-3463-aefd-b86721502ab9|imgt:hasDecision|_:B5b1e13e710f9af840e6632ebc6edb71e imgt:VH-VL-VH%27-VL%27_679|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/VH-VL-VH'-VL'.png imgt:12040|imgt:isImgtStructureEntryOf|imgt:mAb_1265 imgt:Clone_2|rdf:type|obo:NCIT_C37925 _:Bc1be34188996390ecf74b253d9c7abd4|imgt:isDecidedBy|imgt:FDA imgt:Segment_830_3|obo:BFO_0000050|imgt:Construct_830 imgt:IgG1-nd_436|http://semanticscience.org/resource/SIO_000291|imgt:WNV imgt:IgG1-kappa_528|rdfs:comment|IgG1 - kappa imgt:DLL3|imgt:isTargetOf|imgt:IgG1-kappa-2cys-drug_569 imgt:Novartis_Pharmaceuticals_Corp|imgt:produces|imgt:Product_985bd346-6247-3472-834e-799b95b4c76a imgt:mAb_44|imgt:atc_link|http://www.whocc.no/atc_ddd_index/?code=L01XC05 imgt:Product_fe170d32-2e79-37f8-b44b-a495e80a927a|imgt:isProductOf|imgt:mAb_156 imgt:StudyProduct_2394b2ec-3d78-30aa-a147-6fca07f60040|imgt:application_type|Therapeutic imgt:StudyProduct_1289578f-2bc9-3bf7-9a21-741d6e16a068|imgt:development_technology| Abgenix's XenoMouse® imgt:StudyProduct_cac1079e-e48e-330a-a7b6-9da80544e492|rdfs:label|StudyProduct_cac1079e-e48e-330a-a7b6-9da80544e492 imgt:StudyProduct_2885244f-5d5a-36a6-b367-fb9982d41711|imgt:development_technology| Abgenix's XenoMouse® imgt:Product_f5534f35-f0b5-3400-a66f-297adc7553e0|imgt:commun_name|ZHER2:2891-Cys imgt:StudyProduct_d38adcb9-be8c-3c76-a9a7-382cf9420404|imgt:application_type|Therapeutic imgt:StudyProduct_ef02f05c-ea13-311e-975a-324b5b147726|imgt:isStudyProductOf|imgt:Product_3ac0b998-f720-388a-bb51-08f38d12f3e9 imgt:mAb_473|imgt:inn_proposed_list|109 (2013) imgt:IgG3-kappa_1061|imgt:hasConstruct|imgt:Construct_1061 imgt:scFv-h-CH2-CH3_1189|http://semanticscience.org/resource/SIO_000291|imgt:tetravalent _:Ba8eb01a5bb73f2cc03d792c66725b686|imgt:hasStatut|imgt:approval imgt:StudyProduct_f435062c-2f5a-3a33-a817-05bebc17e51d|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:Clone_847|rdfs:label|Clone_847 imgt:Clone_832|imgt:clone_name|AK002 PG1 imgt:IgG4_Kappa|imgt:isDefinedBy|imgt:IG-Heavy-Gamma-4-IGHG4 imgt:Segment_436_1|obo:BFO_0000050|imgt:Construct_436 imgt:StudyProduct_1fd5cdac-9470-3ccd-b72e-92d15d0578c1|rdf:type|obo:NCIT_C174271 imgt:mAb_409|imgt:hasOriginClone|imgt:Clone_409 imgt:StudyProduct_29320b6a-0fab-3d74-aa2a-2e745b830dbd|imgt:isStudyProductOf|imgt:Product_02854504-0320-3b95-8a8f-813bd381554a imgt:Segment_60_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:CPCA_PROTEIN-PEG-FC_826|obo:RO_0002162|imgt:Homsap imgt:MAbReceptor_206|rdfs:label|MAbReceptor_206 imgt:FAB-GAMMA-2B_LAMBDA|skos:definition|Fab comprising the VH-CH1 domains from a H-GAMMA-2B chain and a L-LAMBDA chain imgt:Product_b7184345-eea1-31c7-8d7d-cf29e2d424aa|rdf:type|obo:NCIT_C51980 imgt:mAb_490|rdfs:label|mAb_490 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imgt:FPIA_%5BPROTEIN-PROTEIN-PROTEIN-PROTEIN%5D2-FC_1158|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/FPIA_[PROTEIN-PROTEIN-PROTEIN-PROTEIN]2-FC.png imgt:Clone_132|obo:RO_0002162|imgt:Musmus imgt:IgG2-kappa_2bridges_725|imgt:isMabReceptorOf|imgt:mAb_725 obo:RO_0002517|rdfs:domain|faldo:Region imgt:CD3E|imgt:isTargetOf|imgt:IgG4-kappa_1263 imgt:Construct_860|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:StudyProduct_8362701e-b95a-325e-8288-da965886a6f2|imgt:hasDecision|_:B73b0d0c9e6c40d6a741d3d0e415c3b8b imgt:IgG1-nd_438|rdfs:comment|IgG1 - nd imgt:Product_c9cafb67-7c5b-36ee-93fb-4c7df9648b85|imgt:commun_name|MSL 109 imgt:mAb_857|imgt:inn_proposed_list|119 (2018) imgt:TR-Beta-1-TRBC1|imgt:hasChainTypeLevel|imgt:TR-Beta-TRB imgt:mAb_216|imgt:hasBiosimilar|imgt:brenzys® imgt:StudyProduct_0a85bc23-6d76-3b8d-9920-b9681958b75e|rdf:type|obo:NCIT_C174271 imgt:Product_06138bc5-af60-3364-aede-0e1f7c1eac75|rdfs:label|Product_06138bc5-af60-3364-aede-0e1f7c1eac75 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imgt:StudyProduct_8fb6a13c-fe54-3f1d-93d6-d8eb4c7f93b7|imgt:isStudyProductOf|imgt:Product_a9814a14-a170-37d5-97fd-0fe8732330c2 imgt:Clone_1006|rdf:type|obo:NCIT_C37925 imgt:StudyProduct_fe029148-b943-335c-8af0-e7fe24d86ee1|imgt:hasClinicalPhase|imgt:Phase_I imgt:CD27|obo:RO_0002162|imgt:Homsap imgt:Bio_Products_Laboratory|rdfs:comment|Elstree , UK pubmed:20848453|dc:date|2010 imgt:Product_5c35ec7d-f892-34d7-a57f-2709a11d3612|imgt:isProducedBy|imgt:Aratana_Therapeutics_Inc _:Bd9f52fce09c403f141619631fc6a8dec|imgt:hasStatut|imgt:approval imgt:StudyProduct_c02869ac-3e7f-384b-ade1-ea4d2187a1e8|imgt:hasDecision|_:Bfc0949419dd587e2ccb388ac01fc935e imgt:Segment_1207_1|rdf:type|imgt:Segment imgt:StudyProduct_394b4273-5997-311a-a34c-fcbb3b50571a|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_6e5f2ee6-162d-347d-a21a-5935fa70bf14|imgt:hasClinicalPhase|imgt:Phase_II imgt:FPIA_%5BPROTEIN_PROTEIN%5D2-FC-%5BPROTEIN%5D2_1228|rdfs:comment|FPIA_[PROTEIN_PROTEIN]2-FC-[PROTEIN]2 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imgt:Construct_726|rdf:type|imgt:Construct imgt:StudyProduct_a0cee844-95a7-3621-85d5-dddc3c33fda3|rdfs:label|StudyProduct_a0cee844-95a7-3621-85d5-dddc3c33fda3 imgt:Segment_1124_1|obo:BFO_0000050|imgt:Construct_1124 imgt:Product_8aedac6e-b419-31fb-9ff4-442f5cc9176a|rdf:type|obo:NCIT_C51980 imgt:IgG1-nd_445|rdfs:comment|IgG1 - nd imgt:Product_19035bc7-8361-3721-af18-5bc56c99124d|imgt:commun_name|Hu5F9-G4 imgt:StudyProduct_a2a3e31e-0940-38d5-86a0-dbdc0138f29c|imgt:application_type|Therapeutic imgt:mAb_454|imgt:inn_proposed_list|108 (2012) imgt:Construct_325|rdf:type|imgt:Construct imgt:StudyProduct_8b0a4ec2-0000-38e8-9276-0f63abf619dc|rdfs:label|StudyProduct_8b0a4ec2-0000-38e8-9276-0f63abf619dc imgt:mAb_614|rdf:type|obo:NCIT_C1909 imgt:Construct_476|rdf:type|imgt:Construct imgt:Product_e16c7e73-bafd-3c00-8679-3d3179baac20|imgt:isProducedBy|imgt:Genexine imgt:IgG1-kappa_763|http://semanticscience.org/resource/SIO_000291|imgt:bi-component_leukocidins 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region to increase\r the binding to the human inhibitory Fc receptor FCGR2B, which leads to a\r selective B cell inhibition (XmAb immune inhibitory Fc domain\r technology). imgt:Product_c4281e8f-8be3-33d2-a3b5-de0eaf8f6d6d|imgt:commun_name|IMC-11F8 imgt:Heart_transplant_rejection|imgt:isClinicalIndicationOf|imgt:StudyProduct_c398d23a-1697-3b9d-be1d-6684184d1772 imgt:CH2-CH3|rdf:type|imgt:RPILabel imgt:mAb_702|imgt:hasProduct|imgt:Product_7ec9ad80-b07a-372f-a9a0-a531345ffd64 imgt:Construct_949|obo:BFO_0000051|imgt:Segment_949_1 imgt:scFv-heavy-kappa-CD28_(CO-TM-CY)-CD247_876|rdfs:comment|scFv-heavy-kappa-CD28 (CO-TM-CY)-CD247 imgt:StudyProduct_d08001fe-9bd8-377d-b56d-2cffd39b2bdd|rdf:type|obo:NCIT_C174271 imgt:Product_52d64598-ed50-3201-a067-7767d7a82e62|imgt:isProducedBy|imgt:AbbVie_Inc imgt:Clone_279|imgt:isOriginCloneOf|imgt:mAb_279 imgt:StudyProduct_be16fe6d-28f7-32c8-a8b6-60c46faffce1|rdfs:label|StudyProduct_be16fe6d-28f7-32c8-a8b6-60c46faffce1 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imgt:StudyProduct_a28ba796-a862-39e1-a438-9c58072fb6f1|imgt:isStudyProductOf|imgt:Product_07e0d9b7-856b-34d9-845d-70d1a61bef86 _:Ba60abafd1f665d338144a111e02064a9|rdf:type|obo:NCIT_C53285 imgt:IgG1-lambda-kappa(2)_1119|obo:RO_0002162|imgt:Hum imgt:9519|imgt:isImgtStructureEntryOf|imgt:mAb_491 imgt:Product_d028c76c-dbf1-3420-84a9-31338f6da8fd|imgt:isProducedBy|imgt:Centocor_Ortho_Biotech_Products_LP imgt:HAMP|obo:RO_0002162|imgt:Homsap imgt:StudyProduct_bf8c29b4-cfc3-3b87-833f-e4568c7831db|imgt:application_type|Therapeutic imgt:12050|rdf:type|obo:NCIT_C25402 imgt:StudyProduct_2a2fdb31-208f-35fe-9a78-3a56db5bf468|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:mAb_293|imgt:inn_number|9085 imgt:StudyProduct_81683a1e-9f05-3c20-9ce5-1795547f315b|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_380786ae-bc71-3980-ad18-e13fdcc0b325|rdf:type|obo:NCIT_C174271 imgt:Product_63e4e4b4-5918-3eef-818c-291c25f73777|rdfs:label|Product_63e4e4b4-5918-3eef-818c-291c25f73777 imgt:PGF|rdf:type|obo:NCIT_C25702 imgt:StudyProduct_c1f882ca-c7ae-33f6-a4cf-a85ff91d4c50|imgt:hasClinicalIndication|imgt:Renal_cell_carcinoma_(RCC) imgt:Product_12647c13-9b20-3fa9-a890-b73b5d049a4d|imgt:hasStudyProduct|imgt:StudyProduct_82ee450a-7936-3d78-b5bf-e1b448d27209 imgt:Product_07aac662-fdf7-3468-a89e-5ca369b8c228|imgt:isProductOf|imgt:mAb_238 imgt:Product_2c19b4a9-6777-3025-85ff-b23426b8e887|imgt:isProducedBy|imgt:MacroGenics_Inc imgt:mAb_1177|imgt:hasMabReceptor|imgt:IgG1-kappa_1177 imgt:mAb_941|imgt:inn_recommended_list|83 (2020) _:B81f6b65bc16bdd9d0aaa4afda7e70f56|imgt:isDecisionOf|imgt:StudyProduct_657ccc33-24fa-3743-a75a-6111c145c586 _:B1746c0496196cf0c80835386936cd23f|imgt:hasDesignation|imgt:Orphan_drug imgt:Protalix_Biotherapeutics|rdf:type|obo:NCIT_C54131 imgt:IgG3-kappa_507|imgt:hasMolecularComponent|imgt:IG imgt:mAb_1229|rdf:type|obo:NCIT_C1909 imgt:Influenza_B_infection|imgt:clinical_domain|Infectiology imgt:IG-Light|rdf:type|imgt:ReceptorLevelChainType imgt:mAb_171|rdf:type|imgt:INN imgt:mAb_268|rdfs:label|mAb_268 imgt:Product_b4ab3c62-24b2-3d64-b784-2e7b8f08aeb2|imgt:commun_name|CNTO 888 _:B897291b31934d661bac656415d0230ab|imgt:isDecidedBy|imgt:FDA imgt:StudyProduct_e3cbe99d-6000-3501-9d16-4174cd95c02e|rdfs:label|StudyProduct_e3cbe99d-6000-3501-9d16-4174cd95c02e imgt:TNF|imgt:isTargetOf|imgt:scFv-kappa-heavy_1132 imgt:IgG1-kappa_1264|rdf:type|imgt:MAbReceptor imgt:StudyProduct_9781db57-fbca-397e-a7b8-253e716a7085|imgt:hasClinicalIndication|imgt:Solid_tumors imgt:StudyProduct_2d5ce8c9-7700-3e05-b6c2-4d613c31d3ce|imgt:hasClinicalIndication|imgt:Homozygous_familial_hypercholesterolemia_(HoFH) imgt:Product_52893bc3-54bd-39c4-9455-4c65e11f1653|imgt:isProducedBy|imgt:MedImmune imgt:StudyProduct_5213ac74-1389-31f3-888c-adb13fdebaec|imgt:application_type|Therapeutic imgt:Cancers_esophageal_resectable|rdf:type|obo:NCIT_C185637 imgt:StudyProduct_61bbc8e9-937a-3cfb-9c97-feb20c664192|rdf:type|obo:NCIT_C174271 imgt:Segment_693_1|imgt:hasImgtLabel|imgt:GCG imgt:IgM-nd_147|obo:RO_0002162|imgt:Chi imgt:StudyProduct_1e2f31bb-6853-364b-8c64-1eb1a6ca20c5|imgt:development_technology| Chimeric antigen receptor (CAR) T cell engineering imgt:Product_16598ce5-139e-369a-9c15-ff7fed2d1f12|rdfs:label|Product_16598ce5-139e-369a-9c15-ff7fed2d1f12 imgt:StudyProduct_a4b72b6a-53ce-3ee3-83c5-d44557866ec1|imgt:hasClinicalIndication|imgt:Nasal_polyposis imgt:StudyProduct_7b8151d8-918e-34ec-8cf0-edac2cf91f88|imgt:hasClinicalIndication|imgt:Crohn's_disease_(CD) imgt:scFv-Kappa-Heavy-Toxin|rdf:type|imgt:ReceptorType _:B2856f049fee0ec028886a175ade01d71|dc:date|2017-08-25 imgt:Product_1d8957b9-d04f-3bf2-9ecb-463987894434|imgt:hasStudyProduct|imgt:StudyProduct_0584e143-d0b0-3644-8317-76cde6765c24 imgt:Product_2ca07176-627f-3036-8c58-f334a3ca5f13|rdfs:label|Product_2ca07176-627f-3036-8c58-f334a3ca5f13 imgt:_fucosyltransferase-deficient_CHO_(Chinese_Hamster_Ovary)|rdf:type|imgt:ExpressionSystem imgt:StudyProduct_94109571-0d67-3d99-9eac-55b1be8e6370|imgt:hasClinicalIndication|imgt:Severe_acute_respiratory_syndrome_coronavirus_2_(SARS-CoV-2)_infection_(COVID-19) imgt:StudyProduct_07cdfd23-373b-37c6-b337-251c22b7ea57|rdf:type|obo:NCIT_C174271 imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_df371da4-e263-3018-98c1-f2f5486148fc imgt:StudyProduct_08c22142-db46-3298-b221-05fa460a0128|rdfs:label|StudyProduct_08c22142-db46-3298-b221-05fa460a0128 imgt:mAb_596|imgt:hasProduct|imgt:Product_da697f5a-1938-3687-a103-54610aa291dd imgt:Ig(G1-kappa_G1-lambda)|imgt:construction_detail|Ig(G1 - kappa_G1 - lambda) imgt:Construct_1132|rdf:type|imgt:Construct imgt:microsatellite_instability-high_cancer_(MSI-H)|rdfs:label|microsatellite_instability-high_cancer_(MSI-H) imgt:IgG4-kappa_1015|obo:RO_0002162|imgt:Hum imgt:IgG1-kappa_572|rdfs:comment|IgG1 - kappa imgt:Product_87b4f91f-0f72-3325-99d8-da600f41c074|imgt:commun_name|RN307 imgt:mAb_1231|imgt:inn_proposed_list|125 (2021) imgt:IgG1-kappa_340|rdf:type|imgt:MAbReceptor imgt:StudyProduct_dafe2807-e55e-347a-b1f0-e9f55ac3c4ee|imgt:hasClinicalIndication|imgt:Alopecia_areata _:B52420d01727611996d877ead971a0489|rdf:type|obo:NCIT_C53285 imgt:StudyProduct_d47c64cf-6c2e-3369-8bbd-c2cd0defffc8|rdfs:label|StudyProduct_d47c64cf-6c2e-3369-8bbd-c2cd0defffc8 imgt:StudyProduct_ff1a9f4e-d90b-3b0f-aeee-532955fda8a4|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:mAb_805|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=805 imgt:Segment_261_1|rdf:type|imgt:Segment imgt:mAb_286|imgt:hasMabReceptor|imgt:IgG1-kappa_MM_286 imgt:mAb_476|imgt:hasImgtStructureEntry|imgt:9821 imgt:mAb_1079|imgt:hasProduct|imgt:Product_8e40d11b-1dea-38e9-aaf2-6c863ac47788 imgt:StudyProduct_dc244df2-4247-373b-a140-c4fc448f1daf|imgt:hasClinicalIndication|imgt:Tumors imgt:IgG1-nd_MM_314|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-nd_MM.png imgt:Product_a0a0acd9-1b1b-3f2a-94ce-e55fbf6054e3|imgt:commun_name|ANB-011 imgt:Construct_1226|obo:BFO_0000051|imgt:Segment_1226_1 imgt:Product_db3d4ac6-821a-3423-ba1d-61b8ad6cf363|imgt:hasStudyProduct|imgt:StudyProduct_53931e74-e525-3e5f-a76b-b4b9eef386f2 imgt:Construct_450|rdfs:label|Construct_450 imgt:StudyProduct_b5a3e660-80fb-34f2-91b4-51026be46ae9|imgt:development_technology| BiTE® (Bispecific T cell Engager) technology imgt:ADAMTSL5|skos:definition|ADAMTSL5 (ADAMTS like 5, THSD6) imgt:mAb_561|rdf:type|imgt:INN imgt:Segment_1210_1|rdfs:label|Segment_1210_1 imgt:Construct_846|rdfs:label|Construct_846 imgt:StudyProduct_9956daea-9485-3ff6-953b-301e631be9e2|imgt:hasClinicalPhase|imgt:Phase_M imgt:Product_9a941c85-8139-3957-aae7-5b80ee69224e|imgt:hasStudyProduct|imgt:StudyProduct_d901af09-1ed2-3cfd-87a0-6cebfcfe40e5 _:B14c9148a460f97cb9e8d3a404b8545d9|imgt:isDecidedBy|imgt:FDA imgt:StudyProduct_d17f568c-2f95-3814-9c7b-159fefc500e3|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_2a72939a-3224-3a2d-a0ae-f00eb851199e|imgt:hasDecision|_:B44ff041f194a0d406f50f017f9c2ed2e imgt:IgG1-lambda-3lys-drug_575|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-lambda-3lys-drug.png obo:NCIT_C38692|rdf:type|owl:Class imgt:StudyProduct_271d9873-81bc-3539-8d98-3e0e1868fdb9|rdf:type|obo:NCIT_C174271 imgt:10272|imgt:isImgtStructureEntryOf|imgt:mAb_608 imgt:mAb_1245|imgt:hasOriginClone|imgt:Clone_1245 pubmed:7985543|dc:date|1994 imgt:StudyProduct_801c8339-57b5-3f8c-8836-5923647a48db|imgt:hasClinicalIndication|imgt:Respiratory_Syncytial_Virus_(RSV)_infection imgt:Construct_1221|imgt:hasImgtLabel|imgt:IgG4-kappa imgt:Fab%27-G1-kappa-PEG-PEG_242|imgt:hasConstruct|imgt:Construct_242 imgt:flixabi®|rdfs:label|FLIXABI® imgt:Product_e92a1f6b-b0a8-3d24-915b-82fcb6694c39|rdf:type|obo:NCIT_C51980 imgt:StudyProduct_a577ee5a-abd0-313b-8261-f46ea2830ac1|rdfs:label|StudyProduct_a577ee5a-abd0-313b-8261-f46ea2830ac1 imgt:Segment_1005_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:psl|imgt:isTargetOf|imgt:VH-CH1-VH-V-KAPPA-CH2-CH3_953 imgt:Duchenne_muscular_dystrophy_(DMD)|rdfs:label|Duchenne_muscular_dystrophy_(DMD) imgt:Segment_872_1|imgt:segment_detail|Fc (Fragment constant) imgt:StudyProduct_880ef696-40c5-33fa-b14b-47e26da63dd8|imgt:hasClinicalIndication|imgt:Acute_coronary_syndrome_(ACS) imgt:CPCA_three-helical_bundle_1053|obo:RO_0002162|imgt:syncon imgt:Clone_330|rdfs:label|Clone_330 imgt:Shire_Plc|imgt:produces|imgt:Product_e3686309-2689-3dcf-a5f8-b6119a1bb380 imgt:IFNA2_(interferon_alpha_2)_*a_(K56_H57)_ 24-188|rdf:type|imgt:ConstructLabels imgt:Product_f58ea430-2a54-3467-bc94-a3af8a804da3|imgt:hasStudyProduct|imgt:StudyProduct_4793cfd9-9f6e-316f-af34-11679ce1f677 imgt:11857|imgt:isImgtStructureEntryOf|imgt:mAb_1245 imgt:mAb_942|imgt:inn_number|10953 imgt:9840|imgt:isImgtStructureEntryOf|imgt:mAb_485 imgt:Fab-G1-kappa_421|obo:RO_0002162|imgt:Hum imgt:CCL2|skos:definition|CCL2 (chemokine (C-C motif) ligand 2, C-C motif chemokine 2, monocyte chemoattractant protein-1, MCP-1, monocyte chemotactic and activating factor, MCAF, small inducible cytokine A2, SCYA2, HC11) imgt:scFv-kappa-heavy-CD3E_(CO-TM-CY)_1300|imgt:hasMolecularComponent|imgt:IG imgt:Solid_tumors|imgt:isClinicalIndicationOf|imgt:StudyProduct_a0e0b0c2-9db7-336c-934b-c30a6375d0dd imgt:Segment_150_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:F(AB%27)2-GAMMA-4_KAPPA|rdf:type|imgt:IGProteolyticFragmentLabel imgt:Angiogenesis|imgt:isClinicalIndicationOf|imgt:StudyProduct_97610052-460d-38af-ac52-886cbf118344 imgt:mAb_258|imgt:inn_proposed_list|92 (2004) imgt:mAb_376|rdf:type|imgt:INN imgt:StudyProduct_0073239e-4b51-34b4-b68a-9247058363c5|imgt:hasClinicalPhase|imgt:Phase_III imgt:IgG1-kappa_361|obo:RO_0002162|imgt:Hum imgt:StudyProduct_1892f39a-7a9d-3365-8bf8-9fb65c8dc355|rdf:type|obo:NCIT_C174271 imgt:Fab-G2b-kappa_133|rdfs:comment|Fab - G2b - kappa imgt:IgG1-kappa_542|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:Product_74a59550-4d42-3f89-a148-1a0a0bdafb9f|imgt:isProductOf|imgt:mAb_82 imgt:L-V-J-C-sequence|rdf:type|imgt:Molecule_EntityType imgt:Segment_1296_1|obo:BFO_0000050|imgt:Construct_1296 imgt:mAb_631|imgt:hasBiosimilar|imgt:zarxio™ imgt:Product_d3ad2e1c-9b13-330e-b304-44210fcef926|imgt:hasStudyProduct|imgt:StudyProduct_b7f0bbbe-fdd5-316f-a40d-bd8496cad82e imgt:StudyProduct_02eab5fa-383c-309d-a7ae-08a64adc9956|imgt:hasClinicalPhase|imgt:Phase_III imgt:IgG4-kappa_259|imgt:hasConstruct|imgt:Construct_259 imgt:StudyProduct_506a8738-be67-31c5-b7a4-40d5065a88ce|imgt:application_type|Therapeutic obo:NCIT_C61307|rdfs:subClassOf|obo:NCIT_C1909 imgt:mAb_214|imgt:imgt_note| Immunoadhesin: An immunoadhesin is a protein constituted of binding domain(s) (usually from a receptor, ligand, or cell-adhesion molecule) linked to immunoglobulin constant domains (Fc regions).br /An immunoadhesin is identified by the suffix b-cept/b in its INN. On May 6, 2011, Sanofi-Aventis simplified its name to Sanofi. The INN of ZALTRAP® is aflibercept (and not ziv-aflibercept). imgt:StudyProduct_2b7fdb21-1c4b-3a3a-9d6c-870f0663ad27|imgt:development_technology| No N-glycosylation sites CH2 N84.4A Antibody phage display library imgt:Segment_307_1|obo:BFO_0000050|imgt:Construct_307 imgt:StudyProduct_8da7475e-3570-31e7-a0f5-0cd63432e6ca|rdfs:label|StudyProduct_8da7475e-3570-31e7-a0f5-0cd63432e6ca _:B8b82c2915c35e5edde2e383ae93f6248|imgt:isDecidedBy|imgt:FDA imgt:Clone_92|rdf:type|obo:NCIT_C37925 imgt:12159|rdfs:label|12159 imgt:Athera_Biotechnologies_AB|rdfs:label|Athera Biotechnologies, AB imgt:mAb_447|imgt:hasProduct|imgt:Product_f15ef329-9b53-3cce-8248-2d74b9f2be45 imgt:Clone_1075|rdfs:label|Clone_1075 imgt:mAb_497|rdfs:label|mAb_497 imgt:Product_e69abcdb-3e37-3bed-a630-2ae4ee615e7a|imgt:commun_name|ABX-RB2 imgt:mAb_227|imgt:hasProduct|imgt:Product_2c97ff1c-8864-35a5-9400-a09ca0516e0d imgt:Product_472580a9-a9b7-36d2-8b15-c38c1bd71e1f|imgt:commun_name|LDP-01 imgt:11879|rdfs:label|11879 imgt:mAb_867|imgt:clinical_trials|2 studies found, 1 recruiting imgt:StudyProduct_49e8d5cc-d97b-3254-9441-7552e198c97d|imgt:hasClinicalPhase|imgt:Phase_I imgt:EX3|skos:definition|exon 3 of a GENE-UNIT, L-GENE-UNIT or of a TR C-GENE-UNIT imgt:Solid_tumors|imgt:isClinicalIndicationOf|imgt:StudyProduct_e3511043-51d0-3c6c-9700-bf6720186c42 imgt:Segment_1135_1|obo:BFO_0000050|imgt:Construct_1135 imgt:StudyProduct_2a58432a-6376-3fb1-90d3-e15c5dd1ccac|imgt:application_type|Therapeutic imgt:StudyProduct_0f7e253b-e974-37b2-8035-41e3ff52d2a3|imgt:hasClinicalIndication|imgt:Lombar_radicular_pain obo:NCIT_C175830|rdf:type|owl:Class imgt:Product_2f21f38c-c4c7-35cd-ad08-44995d661608|imgt:hasStudyProduct|imgt:StudyProduct_80a12eef-78f8-319c-9b8b-3bc915c82956 imgt:StudyProduct_e7755a61-bc17-385d-8e2e-53e84a96dc04|rdfs:label|StudyProduct_e7755a61-bc17-385d-8e2e-53e84a96dc04 _:B56a14cf71b8806e2a74d2fb7af6cd68e|imgt:isDecisionOf|imgt:StudyProduct_773868e5-eff6-3aac-a866-62bdf844a898 imgt:StudyProduct_d0b75517-b3bd-32f4-a4dc-f5bfdbf17b0e|rdfs:label|StudyProduct_d0b75517-b3bd-32f4-a4dc-f5bfdbf17b0e imgt:mAb_232|rdfs:label|mAb_232 imgt:mAb_1258|rdf:type|imgt:INN imgt:StudyProduct_794808d5-60bc-384d-80e6-99686e844d7c|rdf:type|obo:NCIT_C174271 imgt:_CHOK1SV_(expresses_glutamine_synthetase_(GS)_endogenously)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_469cff43-353e-3dd0-8e72-af6505cb07c0 imgt:Product_6521ccf6-a005-3cb9-9946-f492ecfeb639|imgt:isProducedBy|imgt:Celimmune_LLC imgt:Construct_712|obo:BFO_0000051|imgt:Segment_712_1 imgt:StudyProduct_cd4ac466-54bc-3572-923e-d007db93a427|imgt:hasClinicalIndication|imgt:Autoimmune_diseases imgt:IgG1-nd_311|http://semanticscience.org/resource/SIO_000291|imgt:RHD imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_11d7cde9-1c65-30b2-ab31-d7861e5ed7cc imgt:erelzi™|rdfs:comment| ERELZI™ (etanercept-szzs GP2015) developed by Sandoz Inc. (Wilson NC USA) approved by FDA on August 30 2016 for multiple inflammatory diseases (it is the third biosimilar approved by FDA press release ). Same clinical indications as ENBREL®. imgt:Construct_646|obo:BFO_0000051|imgt:Segment_646_1 imgt:_CHO_DG44_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_25ba19f2-1677-3261-9e58-0555245f4abc imgt:Construct_465|imgt:isConstructOf|imgt:IgG1-lambda_465 imgt:ReceptorLevelChainType|skos:definition|Identifies a chain type at the receptor level. imgt:Product_7059201d-e2a8-3adc-9d1e-93b8e0e1285d|imgt:commun_name|MSB-0010718C _:B55a42700b26a340405ed71b920ce73d2|imgt:isDecisionOf|imgt:StudyProduct_91d1e008-c2d8-3b4c-8b31-e5faddcb4b37 imgt:Segment_340_1|rdf:type|imgt:Segment imgt:StudyProduct_41b94ce1-b65d-37bc-aa0f-a71002c3a9ae|rdfs:label|StudyProduct_41b94ce1-b65d-37bc-aa0f-a71002c3a9ae imgt:Teva_Pharmaceutical_Industries_Ltd_(Cephalon)|imgt:produces|imgt:Product_97d744b1-4bb8-3b77-b6fc-10c38a6bca9a imgt:ENZ-CARRIER_BIG_687|obo:RO_0002162|imgt:Homsap imgt:mAb_1213|rdfs:label|mAb_1213 obo:NCIT_C80971|rdfs:subClassOf|obo:NCIT_C1909 imgt:FAB-EPSILON_LAMBDA|skos:definition|Fab comprising the VH-CH1 domains from a H-EPSILON chain and a L-LAMBDA chain imgt:StudyProduct_b9686c63-50ec-3155-b913-7bb91f9942bc|imgt:application_type|Therapeutic imgt:Product_87b3f496-ef6a-35d5-9b27-f8d2bffe7e59|rdfs:label|Product_87b3f496-ef6a-35d5-9b27-f8d2bffe7e59 imgt:10427|rdf:type|obo:NCIT_C25402 imgt:11857|rdfs:label|11857 imgt:Fab%27-G2a-kappa_306|http://semanticscience.org/resource/SIO_000291|imgt:CD22 imgt:StudyProduct_233122d6-a975-377b-8d6a-a86d5c73aa72|imgt:hasClinicalPhase|imgt:Phase_I/II imgt:mAb_569|imgt:inn_name|rovalpituzumab tesirine imgt:Product_1e12c0c6-eb05-3874-8847-6f28024a11f1|imgt:commun_name|BMS-986168 imgt:StudyProduct_aaf066df-3656-3025-80a3-0e31ed88ed73|imgt:hasClinicalPhase|imgt:Phase_M imgt:Product_e521e71e-0d27-3157-a807-f8780c379245|imgt:hasStudyProduct|imgt:StudyProduct_701e558a-c895-32b5-b69b-9c77b61645db imgt:StudyProduct_3ac53d4f-6a89-3541-af74-44aeaa9ad28d|imgt:isStudyProductOf|imgt:Product_fe96a2d6-ec45-32a9-ad98-947492fcd282 imgt:9233|rdf:type|obo:NCIT_C25402 imgt:ICAM3|obo:RO_0002162|imgt:Homsap imgt:Construct_1163|obo:BFO_0000051|imgt:Segment_1163_1 imgt:Fab%27-R-Fab%27_222|obo:RO_0002162|imgt:Hum imgt:StudyProduct_795d5952-92e3-312b-bb13-63fd7190f5ac|rdf:type|obo:NCIT_C174271 imgt:Construct_722|rdf:type|imgt:Construct imgt:StudyProduct_8b96f622-b9c8-39bb-bf16-1d60b4f66023|imgt:isStudyProductOf|imgt:Product_35151183-9d05-3e40-99a6-c6765fb8df78 imgt:Segment_608_1|rdfs:label|Segment_608_1 imgt:mAb_490|imgt:inn_number|9558 imgt:Thromboembolic_diseases|rdfs:label|Thromboembolic_diseases imgt:H-GAMMA-2-4|rdf:type|imgt:ChainLabels imgt:StudyProduct_0234e521-ae08-3f75-931a-677e76edd616|imgt:application_type|Therapeutic imgt:mAb_418|rdf:type|obo:NCIT_C166446 imgt:IgG2-lambda_451|http://semanticscience.org/resource/SIO_000291|imgt:IGF2 imgt:AMHR2|skos:definition|AMHR2 (anti-Mullerian hormone receptor type 2, anti-Mullerian hormone receptor type II, MISR2, MISRII, Muellerian inhibiting substance type II receptor) imgt:APP|skos:definition|APP (amyloid beta A4 precursor protein) imgt:StudyProduct_702ba1e4-9623-3711-a85b-44cab303d452|rdfs:label|StudyProduct_702ba1e4-9623-3711-a85b-44cab303d452 obo:NCIT_C139553|rdf:type|owl:Class imgt:mAb_866|imgt:hasOriginClone|imgt:Clone_866 imgt:Arsanis_Inc|rdfs:label|Arsanis, Inc. imgt:mAb_1137|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=1137 imgt:Product_72065904-5cd2-3a91-86dd-6ad874d66bab|imgt:isProducedBy|imgt:Novartis_Pharmaceuticals_Corp imgt:StudyProduct_31b0c07e-c02c-334d-9608-003386de4210|imgt:application_type|Therapeutic imgt:Construct_288|obo:BFO_0000051|imgt:Segment_288_1 imgt:scFv-heavy-heavy|rdf:type|imgt:ConstructLabels imgt:Product_6a9aeddf-c689-31d0-a3b9-ccc3ab651bc5|rdf:type|obo:NCIT_C51980 imgt:StudyProduct_a615d6f8-edad-3175-995f-1095d09a145f|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:mAb_282|imgt:inn_number|8047 imgt:StudyProduct_bbd57bc5-9f9c-39a5-8a24-1a13ad4e4c85|imgt:application_type|Therapeutic imgt:Product_5263e9de-956e-3cc5-9f06-d8273ad3417e|imgt:commun_name|ALD-518 imgt:%5BF9_(coagulation_factor_9_coagulation_factor_IX)_recombinant%5D1-IGHG1_Fc_(Fragment_constant)|rdf:type|imgt:ConstructLabels imgt:Segment_106_1|obo:BFO_0000050|imgt:Construct_106 imgt:StudyProduct_a577ee5a-abd0-313b-8261-f46ea2830ac1|imgt:development_technology| Triomab® (Trifunctional Ab) imgt:%5BVH-CH2-CH3%5D2|rdf:type|imgt:IGEngineeredLabel imgt:mAb_335|rdf:type|obo:NCIT_C95788 imgt:Segment_1057_1|imgt:hasImgtLabel|imgt:(scFv-heavy-kappa)-(scFv-heavy-lambda) imgt:Product_50c4b5c5-024d-321f-b6c3-e7ff39741c4e|imgt:hasStudyProduct|imgt:StudyProduct_fbaf65d7-1fb5-38c9-b9e1-ed12981f6476 imgt:mAb_664|rdf:type|imgt:INN imgt:_CHOK1SV_(lacking_the_glutamine_synthetase_(GS)_gene)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_c460e5d4-3e3b-3ba1-9e8a-f5dbf7fa782f imgt:Product_9dc2e6e7-02dc-385a-9448-66778b7d71e6|imgt:commun_name|UCB6114 imgt:Construct_979|rdfs:label|Construct_979 imgt:IgG1-kappa_231|rdfs:comment|IgG1 - kappa imgt:StudyProduct_7a8a4321-2c20-3c9b-b98e-ac1a3008529e|imgt:hasClinicalIndication|imgt:Solid_tumors imgt:Clone_1251|rdf:type|obo:NCIT_C37925 imgt:TR-Delta-TRDC|rdf:type|imgt:GeneLevelChainType imgt:Construct_1125|rdf:type|imgt:Construct imgt:Segment_1041_1|rdf:type|imgt:Segment imgt:mAb_320|rdf:type|imgt:INN imgt:11486|imgt:isImgtStructureEntryOf|imgt:mAb_1103 imgt:PTK7|obo:RO_0002162|imgt:Homsap imgt:Product_6e2d0940-1eb1-39a8-9091-bb902e58ff4c|rdf:type|obo:NCIT_C51980 _:B97b332decbf3727cb48f7c2a92d50a0b|imgt:hasDesignation|imgt:Orphan_drug imgt:Segment_517_1|rdf:type|imgt:Segment imgt:FUSION-FLT1-KDR-GAMMA-1|skos:definition|FLT1, KDR fused with G1 H-CH2-CH3 imgt:StudyProduct_d7ff2e98-d0a2-3351-9cd5-54d89f2815bc|rdfs:label|StudyProduct_d7ff2e98-d0a2-3351-9cd5-54d89f2815bc imgt:9533|rdf:type|obo:NCIT_C25402 imgt:Product_d6dfe287-8f31-3b65-86a0-04dab9827141|rdf:type|obo:NCIT_C51980 imgt:B_cell_leukemia|imgt:clinical_domain|Oncology imgt:mAb_727|rdf:type|obo:NCIT_C175195 imgt:Segment_1034_1|rdf:type|imgt:Segment _:B01a62006669157e27f2ba94a61089c13|imgt:isDecisionOf|imgt:StudyProduct_3413c33b-a4b2-365e-9fa5-d378577a0308 imgt:L-V-transcript|imgt:hasMoleculeUnit|imgt:transcript_unit imgt:StudyProduct_28790f9e-30be-3e9c-b827-69ba060ccb1e|imgt:application_type|Therapeutic imgt:StudyProduct_2646dc45-9c3a-3d98-a6de-31529e9d7f36|imgt:application_type|Therapeutic imgt:10539|imgt:isImgtStructureEntryOf|imgt:mAb_632 imgt:mAb_377|imgt:hasMabReceptor|imgt:FPIA_%5BPROTEIN-PROTEIN-PROTEIN%5D2-FC_377 imgt:PTPRC|skos:definition|PTPRC (protein tyrosine phosphatase  receptor type C, CD45, GP180, LCA, T200) imgt:IgG1-kappa_1194|rdfs:label|IgG1-kappa_1194 imgt:Construct_1013|rdf:type|imgt:Construct imgt:ERBB2|imgt:isTargetOf|imgt:IgG1-kappa_931 imgt:Segment_432_1|imgt:has_rank|1 imgt:IgG1-kappa_845|obo:RO_0002162|imgt:Hum imgt:Myelofibrosis|imgt:clinical_domain|Hematology imgt:Achondroplasia|rdf:type|obo:NCIT_C185637 imgt:StudyProduct_050e0457-5729-3bf5-bac6-20cba72a2a7a|imgt:isStudyProductOf|imgt:Product_2cb0cab5-75d3-3ff4-8cf5-4895a2fa5226 imgt:3C08|imgt:isImgtStructureEntryOf|imgt:mAb_39 _:Bb1e685fc4cc7fe7e0a1a03b9ce188440|imgt:isDecisionOf|imgt:StudyProduct_1ab8d4c3-d225-3383-97de-5f1bb986f6f1 imgt:BETA-ALPHA1_985|imgt:hasConstruct|imgt:Construct_985 imgt:Segment_1005_1|rdfs:label|Segment_1005_1 imgt:StudyProduct_b93864b8-b15d-3309-8103-c041e9e8e8c9|imgt:isStudyProductOf|imgt:Product_dfc3c844-1dac-3fea-9425-5b738ba42245 imgt:mAb_528|imgt:inn_name|durvalumab imgt:Construct_475|rdf:type|imgt:Construct imgt:Product_8f6778ef-a64d-388c-88a1-0e1430c26f55|imgt:isProducedBy|imgt:Eli_Lilly imgt:IL4R|imgt:isTargetOf|imgt:IgG4-kappa_1198 imgt:StudyProduct_b37340c5-5253-3c62-a4a0-1145dd4ec43e|rdfs:label|StudyProduct_b37340c5-5253-3c62-a4a0-1145dd4ec43e imgt:mAb_104|imgt:hasMabReceptor|imgt:IgG1-nd_104 imgt:Product_643b4245-4368-3cc6-9e2e-c746cf6d7ea5|imgt:commun_name|XENP-5574 imgt:StudyProduct_cfc283b3-c688-3da8-ad58-33f8486263eb|imgt:application_type|Therapeutic imgt:Glioblastoma|rdf:type|obo:NCIT_C185637 imgt:IgG1-nd_42|http://semanticscience.org/resource/SIO_000291|imgt:HSV imgt:Product_7ce9196a-555d-310a-97a0-5462869c1f74|rdf:type|obo:NCIT_C51980 imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_497a6171-44e6-3428-9271-bc583559812a imgt:mAb_361|imgt:hasMabReceptor|imgt:IgG1-kappa_361 imgt:mAb_378|imgt:inn_number|9482 imgt:mAb_57|imgt:hasBibliographicReference|https://doi.org/10.1016/0161-5890(94)00146-R imgt:StudyProduct_6d7340cc-1f90-32b0-9fd2-19c06894bb0b|imgt:application_type|Therapeutic imgt:Product_f4af35da-7830-3280-b962-8cc6e7f4bd35|imgt:hasStudyProduct|imgt:StudyProduct_a653ecce-5953-3e12-95f3-70101cdfde28 imgt:Product_0061a6f8-1d2e-3272-82b4-cf993d16ec5d|imgt:commun_name|unconjugated: BAY 86-1903 imgt:FAB-GAMMA-2_V-LAMBDA-C-KAPPA|rdf:type|imgt:IGProteolyticFragmentLabel imgt:mAb_1088|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=1088 imgt:StudyProduct_93df20bb-0444-3290-9ab8-552809ed8377|imgt:application_type|Therapeutic imgt:scFv-kappa-heavy-CD8A_(CO-TM)-TNFRSF9_(CY)-CD247_1301|imgt:fused_with| CD8A (CO-TM) - TNFRSF9 (CY1) - CD247 (CY2) (1:1) imgt:mAb_92|imgt:inn_recommended_list|59 (2008) imgt:Lymphoma_diffuse_large_B_cell_(DLBCL)|imgt:isClinicalIndicationOf|imgt:StudyProduct_e7cc3045-1106-3c23-b405-93d454c3ec63 imgt:Product_5476fc80-3a08-32aa-9c6a-142caa48e5ed|rdfs:label|Product_5476fc80-3a08-32aa-9c6a-142caa48e5ed imgt:IgG1-kappa_958|imgt:hasMolecularComponent|imgt:IG imgt:IgG2-kappa_484|rdf:type|imgt:MAbReceptor imgt:StudyProduct_31ef0b93-ca9d-32bb-83cc-86d57abf70c4|rdfs:label|StudyProduct_31ef0b93-ca9d-32bb-83cc-86d57abf70c4 _:Bbc4f615119f38bc54e8d34bb80338314|rdf:type|owl:AllDisjointClasses imgt:Staphylococcal_sepsis_in_infants_with_low_birth_weight|imgt:isClinicalIndicationOf|imgt:StudyProduct_ea340336-e89e-3870-8589-fbab497767b7 imgt:IL6ST|rdf:type|imgt:SegmentLabels obo:NCIT_C170383|rdf:type|owl:Class imgt:Product_2cb15a3e-feff-380a-a4cd-ce375f581bfc|imgt:commun_name|Joulferon imgt:StudyProduct_f99847c7-7940-338f-926e-0a7ea22fa2e0|imgt:application_type|Therapeutic imgt:Construct_1285|rdf:type|imgt:Construct imgt:Product_5fc9aa53-f083-3789-8cf2-ea4a5852e7d2|rdfs:label|Product_5fc9aa53-f083-3789-8cf2-ea4a5852e7d2 imgt:Construct_1188|rdf:type|imgt:Construct imgt:Solid_tumors|imgt:isClinicalIndicationOf|imgt:StudyProduct_98533fcd-e194-327a-8789-8909fce031a5 imgt:IgG1-kappa_172|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:3D_2DLabel|rdfs:label|3D_2DLabel imgt:StudyProduct_30f1e3f7-8634-3b1c-b40a-0a2722a5b718|imgt:isStudyProductOf|imgt:Product_cfe88c2c-d2ae-3147-9c05-ec936c4308da imgt:Construct_609|rdfs:label|Construct_609 imgt:Segment_1215_1|rdfs:label|Segment_1215_1 imgt:IgG1-kappa_1141|obo:RO_0002162|imgt:Homsap imgt:Segment_731_1|rdf:type|imgt:Segment imgt:StudyProduct_735319b1-25b9-3224-8bba-19ee5b4fd700|rdfs:label|StudyProduct_735319b1-25b9-3224-8bba-19ee5b4fd700 imgt:IgG4-kappa_752|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG4-kappa.png imgt:mAb_156|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=156 imgt:Green_cross_Corp|imgt:produces|imgt:Product_71c50c60-aeac-3b5e-a928-93a7411e1764 imgt:Segment_698_2|rdf:type|imgt:Segment imgt:mAb_887|imgt:hasImgtStructureEntry|imgt:10905 imgt:mAb_756|imgt:inn_proposed_list|117 (2017) imgt:Product_3fbfe977-f5f9-381b-94d0-489e229f2eaf|imgt:hasStudyProduct|imgt:StudyProduct_4c044125-ddc6-3ee4-a8a4-cfbe742e6499 imgt:Segment_1144_1|obo:BFO_0000050|imgt:Construct_1144 imgt:Respiratory_Syncytial_Virus_(RSV)_infection|imgt:isClinicalIndicationOf|imgt:StudyProduct_df6b4d85-4d81-3767-a4ec-2d3c0827888c imgt:V-KAPPA-VH-CH2-CH3|rdfs:label|V-KAPPA-VH-CH2-CH3 imgt:Product_73e835ec-f2f0-3c7f-9278-25c653d1147e|imgt:hasStudyProduct|imgt:StudyProduct_be6e6aeb-e25a-3b7b-8bba-6d8eb655e6d9 imgt:Product_dbe05b64-0640-322a-811c-7c37fcafe09b|rdf:type|obo:NCIT_C51980 imgt:Synermore|rdfs:comment|null , China imgt:PROTEIN_2DOMAINS_2F_278|rdfs:label|PROTEIN_2DOMAINS_2F_278 imgt:StudyProduct_b0bb0702-9e9a-3783-97b1-b32ed1cc0a37|rdfs:label|StudyProduct_b0bb0702-9e9a-3783-97b1-b32ed1cc0a37 imgt:11907|rdfs:label|11907 imgt:mAb_417|imgt:hasImgtStructureEntry|imgt:9575 imgt:Cancers_lung|rdf:type|obo:NCIT_C185637 imgt:mAb_21|imgt:inn_proposed_list|98 (2007) imgt:mAb_100|imgt:hasOriginClone|imgt:Clone_100 imgt:mAb_475|imgt:hasProduct|imgt:Product_5fd4206e-e7a6-3a22-81dc-b206288ecfd0 imgt:Construct_278|rdf:type|imgt:Construct imgt:IgG4-kappa_1066|imgt:hasConstruct|imgt:Construct_1066 imgt:Product_ce6784de-9fa1-3432-ab5d-4af00f8d4461|imgt:isProducedBy|imgt:Scotgen_Biopharmaceuticals_Ltd imgt:Segment_42_1|imgt:hasImgtLabel|imgt:IgG1-nd imgt:unprocessed|rdfs:label|unprocessed imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_d27f3450-4dac-3002-9b81-f849b03174fa imgt:StudyProduct_e0acf019-fd3a-31ba-877a-9789cc6dd262|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_beb58537-8503-3cb1-a6b2-0deccc1df0f7|imgt:hasExpressionSystem|imgt:_CHO-S_(Chinese_Hamster_Ovary)_cells_suspension_culture imgt:Product_c43354f7-d1ee-3952-bf61-d7f3d2f18d35|imgt:commun_name|QL1706 (iparomlimab + tuvonralimab) imgt:Construct_1245|rdf:type|imgt:Construct imgt:Construct_979|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Segment_729_1|rdfs:label|Segment_729_1 _:B347b970e757b284215efb8aeca508657|imgt:isDecidedBy|imgt:FDA imgt:Segment_491_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Product_35bd5711-24c5-3f61-b2db-ffaa28dc248f|imgt:hasStudyProduct|imgt:StudyProduct_2f36dbe6-8922-3f04-8f29-d60d9e29310b imgt:IL22RA1|skos:definition|IL22RA1 (interleukin 22 receptor subunit alpha 1, IL22R) imgt:StudyProduct_fb30b8f9-dd65-35ff-8196-c856fac2bab1|imgt:application_type|Therapeutic imgt:Product_eddea82a-d275-3b24-84e1-68c5fc2ebd40|imgt:isProductOf|imgt:mAb_309 imgt:scFv-G1K-scFv-scFv_kappa_1248|imgt:isMabReceptorOf|imgt:mAb_1248 imgt:Product_1ff282bc-eb72-3378-9c95-2ad8aac8ba1d|imgt:isProductOf|imgt:mAb_542 imgt:Melanoma_metastatic_or_unresectable|rdf:type|obo:NCIT_C185637 imgt:%5BscFv%5D2-Fc-%5BscFv%5D2_580|rdfs:label|[scFv]2-Fc-[scFv]2_580 _:B9666c938ad8e51fa7d9d7af12883e77d|rdf:type|obo:NCIT_C53285 imgt:Product_1ee293d6-44ea-3bcb-84c3-b34b51c264d4|imgt:commun_name|KH903 imgt:StudyProduct_bd3a5690-76d8-3798-bc05-a5cc72b447c9|imgt:hasDecision|_:Bc0ffd49b07bc4381f6d797b2bb717910 imgt:Atherosclerosis|imgt:isClinicalIndicationOf|imgt:StudyProduct_56707d84-4db0-39aa-b4f3-46813eb2b013 imgt:Product_45764f66-c3ab-3d8a-83e6-4c68ea46c921|rdf:type|obo:NCIT_C51980 imgt:INTEGRIN-ALPHA-1|skos:definition|integrin chain imgt:FPIALabel|skos:definition|Fusion protein for immune application pubmed:10561020|rdfs:label|PMID_10561020 imgt:StudyProduct_8b96f622-b9c8-39bb-bf16-1d60b4f66023|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_570b0f62-6343-325d-9344-8d8294daefd4|rdfs:label|StudyProduct_570b0f62-6343-325d-9344-8d8294daefd4 imgt:mAb_594|rdfs:label|mAb_594 imgt:StudyProduct_b773e9af-4dab-3a2b-bbe9-84818f1cb689|imgt:hasClinicalIndication|imgt:Hodgkin_lymphoma imgt:mAb_971|imgt:hasProduct|imgt:Product_02fe4a68-d0bb-3cbf-b94d-94fcfd5ced22 imgt:StudyProduct_7a8a4321-2c20-3c9b-b98e-ac1a3008529e|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:mAb_335|imgt:inn_recommended_list|64 (2010) imgt:mAb_1249|rdf:type|imgt:INN imgt:CH3|skos:definition|exon CH3 of IG heavy C-GENE in gDNA, or third C-DOMAIN of IG heavy chain in cDNA imgt:StudyProduct_09cb89dc-7fb2-3f6a-980e-48d78bdb7716|imgt:hasClinicalPhase|imgt:Phase_I/II imgt:StudyProduct_c281a7dc-7fff-3212-94c1-f5032d7febb8|imgt:hasClinicalPhase|imgt:Phase_II imgt:Construct_531|rdf:type|imgt:Construct imgt:mAb_1075|imgt:hasProduct|imgt:Product_32b86460-a45e-3754-b094-c62785f30884 imgt:ImmunoGen_Inc|imgt:produces|imgt:Product_032579b1-dca3-3eba-bb14-e6a77024cc1e obo:NCIT_C184861|rdf:type|owl:Class imgt:IgG1-kappa_660|http://semanticscience.org/resource/SIO_000291|imgt:RSPO3 imgt:IgM_Iota-1|imgt:isDefinedBy|imgt:IG-Heavy-Mu-IGHM imgt:StudyProduct_bfac3108-ff6d-3d7a-8598-e41a89114546|imgt:hasClinicalPhase|imgt:Phase_II imgt:StudyProduct_0ae58a41-d2e8-309f-b71e-9fe54e2f4945|rdf:type|obo:NCIT_C174271 imgt:PROTEIN_1DOMAIN_709|imgt:isMabReceptorOf|imgt:mAb_709 imgt:StudyProduct_f244e619-5a88-3ace-9aa7-5f67061ae5bf|imgt:hasExpressionSystem|imgt:_E.coli_(Escherichia_coli) imgt:IgG1-kappa_98|imgt:hasMolecularComponent|imgt:IG imgt:STEAP1|skos:definition|STEAP1 (six transmembrane epithelial antigen of the prostate 1, PRSS24, STEAP) imgt:StudyProduct_8dcdbc19-94fa-3962-86c1-8bf267c075df|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_0fde7fe1-e260-3c20-9361-f9caebe22024|rdfs:label|StudyProduct_0fde7fe1-e260-3c20-9361-f9caebe22024 imgt:Segment_1293_1|imgt:has_rank|1 imgt:mAb_558|rdf:type|imgt:INN imgt:mAb_271|imgt:inn_number|8370 imgt:StudyProduct_06e7149d-15e8-3596-a3c5-bf9a81d15c55|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_5606563b-dbd0-3f8d-a77d-be0d9980fb7c|imgt:hasDecision|_:Bc2a59547244489488a0d39580a99e304 imgt:StudyProduct_91c9ac2b-c058-3172-8668-dba24e6176a0|imgt:hasClinicalPhase|imgt:Discontinued imgt:mAb_442|imgt:hasMabReceptor|imgt:IgG4-nd_442 imgt:IgGE|imgt:isTargetOf|imgt:IgG1-kappa_837 _:B87d2510fa084321309ce408e52cecaea|imgt:isDecidedBy|imgt:FDA imgt:FUSION-TNFSF10-GAMMA-1|skos:definition|TNFSF10 fused with G1 H-CH2-CH3 imgt:IgG1-kappa_283|rdf:type|imgt:MAbReceptor imgt:Clone_34|imgt:isOriginCloneOf|imgt:mAb_34 imgt:mAb_905|imgt:inn_number|10962 imgt:IgG2-kappa_2bridges_725|obo:RO_0002162|imgt:Can imgt:Product_c4281e8f-8be3-33d2-a3b5-de0eaf8f6d6d|imgt:hasStudyProduct|imgt:StudyProduct_19d23e6a-0f31-3650-a817-d2389d919f74 imgt:scFv-kappa-heavy-CD28_(CO-TM-CY)-CD247_827|imgt:hasMolecularComponent|imgt:IG imgt:mAb_156|imgt:hasBiosimilar|imgt:ixifi™ imgt:Product_662ce514-9b8c-3064-9c7b-0ab10d0cc09b|imgt:commun_name|meplazumab imgt:Product_69f241fb-fccf-37aa-ae20-71bcefe5dfbb|imgt:isProductOf|imgt:mAb_128 imgt:3SBio_Inc|rdfs:label|3SBio Inc. imgt:StudyProduct_511551d8-5a7b-332f-9ab1-30391265e771|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:Fab-Gamma-2-a_Lambda|rdf:type|imgt:ReceptorType imgt:Segment_1193_1|rdf:type|imgt:Segment imgt:MASP2|rdf:type|obo:NCIT_C25702 imgt:Product_0872db0d-9d18-336b-aa58-45b3210cb065|imgt:commun_name|BEC2 imgt:StudyProduct_c8dad9b0-2c1e-3c06-8d49-121c7f612e1f|imgt:isStudyProductOf|imgt:Product_bf6d0ac4-ff7a-36cb-8a46-33427568ee37 imgt:GeneType|owl:disjointWith|imgt:MolecularComponent imgt:Product_55f62e0c-5feb-32b7-8886-a382d130f9e5|imgt:isProductOf|imgt:mAb_271 imgt:1V-LIKE-1C-LIKE-EXOTOXIN_A|skos:definition|Chain comprising one V-LIKE, one C-LIKE domains and an exotoxin A imgt:mAb_96|imgt:inn_proposed_list|90 (2004) imgt:mAb_610|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=610 imgt:IL22_(interleukin_22_IL-22_ILTIF_IL-TIF)-IGHG4_Fc_(Fragment_constant)|rdfs:label|IL22 (interleukin 22, IL-22, ILTIF, IL-TIF) - IGHG4 Fc (Fragment constant) imgt:StudyProduct_1eb6cf78-9da8-386d-a438-46e24b0e35c3|imgt:isStudyProductOf|imgt:Product_dc4a2050-c9d1-3906-a4ef-91161c062c3d imgt:Product_9167f067-90ce-3085-a54d-a51746667cfb|imgt:commun_name|HuPRO-140 imgt:mAb_969|rdf:type|imgt:INN imgt:IgG1-kappa-4cys-drug_493|rdfs:comment|IgG1 - kappa - 4cys - drug imgt:Segment_584_1|imgt:has_rank|1 imgt:StudyProduct_a16c7adc-c7ec-3d07-8ce3-6d3015f1909d|rdfs:label|StudyProduct_a16c7adc-c7ec-3d07-8ce3-6d3015f1909d imgt:IgG1-kappa_371|imgt:hasConstruct|imgt:Construct_371 imgt:mAb_254|imgt:inn_name|tucotuzumab celmoleukin imgt:GeneLevelChainType|rdf:type|owl:Class imgt:Clone_1250|imgt:isOriginCloneOf|imgt:mAb_1250 imgt:Segment_138_1|rdf:type|imgt:Segment imgt:10681|imgt:isImgtStructureEntryOf|imgt:mAb_770 imgt:FASLG|imgt:isTargetOf|imgt:FPIA_%5BPROTEIN_3REPEATS%5D2-3S-FC_530 imgt:IgG1-kappa_560|http://semanticscience.org/resource/SIO_000291|imgt:MUC1 imgt:mAb_617|imgt:hasProduct|imgt:Product_4dc025d9-1a02-3974-9131-37a906a286fa imgt:Segment_969_1|rdfs:label|Segment_969_1 imgt:Segment_723_1|rdf:type|imgt:Segment imgt:Renal_transplant_rejection|rdfs:label|Renal_transplant_rejection _:Bd4c073dc1dfdcf018d16c24cfbac9ffe|rdf:type|obo:NCIT_C53285 imgt:IgG1-kappa_1104|http://semanticscience.org/resource/SIO_000291|imgt:Severe_acute_respiratory_syndrome_coronavirus_2_(SARS-CoV-2) imgt:StudyProduct_96d1bc00-2ad6-3412-9e0a-9c8828bf4f1d|rdfs:label|StudyProduct_96d1bc00-2ad6-3412-9e0a-9c8828bf4f1d imgt:StudyProduct_c18dfb91-f043-3ef9-9383-04d13a25ce28|imgt:hasDecision|_:B6fbf671ce56e1c42c03fe69d0a5669c9 imgt:StudyProduct_5e4d56c3-87f8-365e-b05c-33017bfd1933|imgt:application_type|Therapeutic imgt:sterile_transcript|rdfs:label|sterile_transcript imgt:Construct_845|imgt:isConstructOf|imgt:IgG1-kappa_845 imgt:StudyProduct_84e32db6-70db-3328-968a-3daaa74a54bd|rdfs:label|StudyProduct_84e32db6-70db-3328-968a-3daaa74a54bd _:Bbadcbc5155957c585989be89c4e37b6f|imgt:isDecidedBy|imgt:EMA imgt:truncated|rdf:type|imgt:Molecule_StructureType imgt:StudyProduct_94d0a7b8-71f4-33c7-becb-5219629da21d|imgt:isStudyProductOf|imgt:Product_db3d4ac6-821a-3423-ba1d-61b8ad6cf363 imgt:Segment_983_1|imgt:hasImgtLabel|imgt:IL15 imgt:Construct_1183|rdfs:label|Construct_1183 imgt:IgG4-kappa-protein_982|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG4-kappa-protein.png _:Be4c823d25d4e5f560f6ad791ad8a7f3c|imgt:isDecidedBy|imgt:FDA imgt:FLT3|rdf:type|obo:NCIT_C25702 imgt:StudyProduct_dece01d9-67ae-3cd7-8c6c-b0a053d1f3e8|imgt:hasClinicalPhase|imgt:Phase_M imgt:F(AB%27)2-MU_KAPPA|skos:definition|F(ab')2 comprising the VH-CH1 domains from two H-MU chains and two L-KAPPA chains imgt:H-gamma1_L-kappa-scFv(heavy-kappa)_1138|rdf:type|imgt:MAbReceptor imgt:IgG1-kappa_547|imgt:hasMolecularComponent|imgt:IG imgt:Clone_190|rdfs:label|Clone_190 imgt:StudyProduct_7d26bd1b-78c2-3d59-a321-1c9ffaca80e9|imgt:hasClinicalPhase|imgt:Phase_I imgt:StudyProduct_0f7e253b-e974-37b2-8035-41e3ff52d2a3|imgt:application_type|Therapeutic _:Bde3ad9e05eb510f656bcf39f94d4efb9|imgt:isDecidedBy|imgt:FDA imgt:Segment_937_1|rdf:type|imgt:Segment imgt:Product_579626b2-3936-3f6e-aed4-612d77af1c4e|imgt:hasStudyProduct|imgt:StudyProduct_5dfe30be-eda1-3639-8dea-4939175ff170 imgt:StudyProduct_d64333ec-cf02-36ce-82e7-e744a8d3d307|imgt:hasClinicalPhase|imgt:Phase_I imgt:mAb_1288|imgt:inn_name|vobramitamab imgt:Construct_1034|rdf:type|imgt:Construct imgt:IgG1-kappa_875|imgt:hasConstruct|imgt:Construct_875 imgt:Fab-G1-kappa_84|rdfs:comment|Fab - G1 - kappa imgt:StudyProduct_dfb01347-79d7-3f8d-b192-1e95a225d3c4|rdfs:label|StudyProduct_dfb01347-79d7-3f8d-b192-1e95a225d3c4 imgt:StudyProduct_939b3314-6b35-370e-aadb-30c09a6e28f6|imgt:hasClinicalPhase|imgt:Phase_II imgt:Clone_222|imgt:clone_name|22 (anti-FcγRI) _:B5945554228cbc765b607198217bca299|imgt:isDecisionOf|imgt:StudyProduct_64df6f56-9ee1-3540-ae4c-8f714b5cdb93 imgt:StudyProduct_1139de5f-d2df-3035-acd7-dd41b73b2066|imgt:hasExpressionSystem|imgt:_E.coli_(Escherichia_coli) imgt:Construct|rdfs:label|Construct imgt:IgG1-nd_4|rdf:type|imgt:MAbReceptor imgt:Segment_365_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:StudyProduct_a6ee05b5-a108-3728-9f5b-572b4b75c954|imgt:hasExpressionSystem|imgt:_E.coli_(Escherichia_coli) imgt:StudyProduct_0234e521-ae08-3f75-931a-677e76edd616|imgt:hasClinicalPhase|imgt:Phase_III imgt:mAb_1270|rdf:type|imgt:INN imgt:PROTEIN_1DOMAIN_683|imgt:hasMolecularComponent|imgt:RPI imgt:mAb_624|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=624 imgt:F(AB%27)2-GAMMA-2C_LAMBDA|rdf:type|imgt:IGProteolyticFragmentLabel imgt:StudyProduct_6ffca9d6-47be-3885-833e-fc7f8d57c423|imgt:isStudyProductOf|imgt:Product_e521e71e-0d27-3157-a807-f8780c379245 imgt:IL15RA|rdf:type|imgt:SegmentLabels imgt:StudyProduct_9198fe52-58d2-3469-ab9e-15ced49c24a2|rdf:type|obo:NCIT_C174271 pubmed:10894828|imgt:isBibliographicReferenceOf|imgt:mAb_131 imgt:Product_d2501478-25a5-378b-ae83-ee188222f233|imgt:commun_name|LDP02 imgt:StudyProduct_6b12cc8b-fb90-35c4-9c2b-37dcf5c052cd|imgt:isStudyProductOf|imgt:Product_2cc853dd-e3c6-3e19-a19e-85aa74315a15 imgt:IgG2-G4-kappa_356|imgt:isMabReceptorOf|imgt:mAb_356 imgt:IgG4-kappa_1030|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG4-kappa.png imgt:mAb_850|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=850 imgt:mAb_1266|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=1266 imgt:Clone_590|rdfs:label|Clone_590 imgt:StudyProduct_e9a7c8f3-f7cf-359e-b817-11dba4592ec9|imgt:hasClinicalIndication|imgt:Solid_tumors imgt:Segment_527_1|imgt:hasImgtLabel|imgt:IgG2-kappa imgt:C4B|rdfs:label|C4B imgt:StudyProduct_1aea0703-4fa8-3be8-823e-3a0b4259c959|imgt:hasClinicalPhase|imgt:Phase_II imgt:SCFV-KAPPA-HEAVY-VH1-CH1-CH2-CH3-SCFV-HEAVY-KAPPA-SCFV-HEAVY-KAPPA|skos:definition|Ig-Heavy-Gamma-1 chain comprising SCFV-KAPPA-HEAVY-VH1-CH1-CH2-CH3-SCFV-HEAVY-KAPPA-SCFV-HEAVY-KAPPA imgt:IgG1-nd_MM_281|rdfs:comment|IgG1-nd_MM imgt:Osteosarcoma|imgt:clinical_domain|Oncology imgt:mAb_969|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=969 imgt:IG-Heavy-Gamma-4-IGHG4|rdf:type|imgt:ChainType imgt:IgG1-nd_MM_7|http://semanticscience.org/resource/SIO_000291|imgt:VEGFA _:B2cbdd5a75de68cf17f0c6f365f022ab3|dc:date|2016-01-27 imgt:IG-Heavy-Alpha-1-IGHA1|imgt:isDescribedBy|imgt:H-ALPHA-1 imgt:FC-GAMMA-2B|rdf:type|imgt:IGProteolyticFragmentLabel imgt:Construct_708|rdf:type|imgt:Construct imgt:StudyProduct_d45b483c-0c49-395a-bcab-dce618341e33|imgt:application_type|Therapeutic imgt:Clone_1168|imgt:clone_name|1501-2D1 imgt:mAb_806|imgt:clinical_trials|1 studies found, 1 recruiting imgt:grasustek|rdfs:label|GRASUSTEK imgt:Segment_49_1|obo:BFO_0000050|imgt:Construct_49 imgt:CONJUGATE-%5BOXYNTOMODULIN-ANALOG-PEGLINK%5D1-FC-GAMMA-4|rdf:type|imgt:CPCALabel imgt:Product_84a2dc5c-f110-3334-bc8a-686353a3e2f3|imgt:isProductOf|imgt:mAb_678 obo:NCIT_C171843|rdfs:subClassOf|obo:NCIT_C1909 imgt:Construct_438|rdf:type|imgt:Construct imgt:Product_580ef4ed-4216-3856-a1a6-e16fceee2855|imgt:hasStudyProduct|imgt:StudyProduct_71e46760-7799-3358-acaf-2ab6daddc448 imgt:F9_(coagulation_factor_9_coagulation_factor_IX)-CTP_(C-terminal_peptide_of_the_β-subunit_of_human_chorionic_gonadotropin_(hCG))|imgt:construction_detail|Fusion - F9 (coagulation factor 9, coagulation factor IX) - CTP (C-terminal peptide of the β-subunit of human chorionic gonadotropin (hCG)) imgt:mAb_604|rdf:type|obo:NCIT_C152812 imgt:PROTEIN_1DOMAIN_1291|obo:RO_0002162|imgt:Homsap imgt:MoleculeFunctionalityType|rdf:type|owl:Class imgt:mAb_1284|imgt:hasImgtStructureEntry|imgt:11774 imgt:Product_e3686309-2689-3dcf-a5f8-b6119a1bb380|imgt:hasStudyProduct|imgt:StudyProduct_ff4083b3-ec46-369f-933e-8fe34db76e6d imgt:StudyProduct_cd8c4be3-9b48-3ec5-8307-590cfb4308b5|imgt:isStudyProductOf|imgt:Product_92aaaa11-a012-35e5-91ee-9df570fa89a7 imgt:IgG1-kappa_1240|obo:RO_0002162|imgt:Chi pubmed:25788700|dc:contributor|Janefeldt A imgt:Clone_867|obo:RO_0002162|imgt:Musmus imgt:Construct_666|imgt:isConstructOf|imgt:IgG1-lambda_666 imgt:Product_8a9500c5-8ecc-394a-895a-d1c0ba3b48bc|imgt:isProducedBy|imgt:National_Cancer_Institute imgt:11416|rdf:type|obo:NCIT_C25402 imgt:Product_82d6fc7f-1e50-3627-b139-c7c5ec05c31b|imgt:isProductOf|imgt:mAb_581 imgt:StudyProduct_cbe90bfe-6f84-3a8b-9143-95c5b5332204|imgt:hasClinicalIndication|imgt:Cancers_breast imgt:Segment_448_1|imgt:has_rank|1 imgt:Construct_919|rdf:type|imgt:Construct imgt:SCFV-HEAVY-KAPPA_FUSION-H-GAMMA-1-IL2|skos:definition|IG receptor comprising one SCFV-HEAVY-KAPPA and one KAPPA_FUSION-H-GAMMA-1-IL2 imgt:Segment_718_1|rdfs:label|Segment_718_1 imgt:mAb_585|imgt:imgt_note| olendalizumab INN name is the one amended in L116 (2016) and published in R77 (2017) (in replacement of lendalizumab L114). Please note that this product was withdrawn from the Community register of designated orphan medicinal products in September 2017 on request of the sponsor. imgt:mAb_450|imgt:hasImgtStructureEntry|imgt:9672 imgt:StudyProduct_6395a513-b609-3c18-91ed-2389e408549b|imgt:isStudyProductOf|imgt:Product_c7f1d535-33e6-32f8-8320-06c648b7ccc4 imgt:Product_3086b99e-8c37-3a44-8aaf-14e046e82b3b|imgt:hasStudyProduct|imgt:StudyProduct_8483c2ef-bfdc-3068-9769-356981862caa imgt:Novartis_Pharmaceuticals_Corp|imgt:produces|imgt:Product_1e3e70cb-9c74-352f-bc15-c39c41590fbc imgt:Product_0d23f5a7-b8cb-3eb8-ba07-41a57852fdf3|imgt:isProducedBy|imgt:MedImmune imgt:mAb_645|imgt:inn_proposed_list|115 (2016) imgt:StudyProduct_5aaf2721-67bc-315b-8810-084f9246df86|rdfs:label|StudyProduct_5aaf2721-67bc-315b-8810-084f9246df86 imgt:StudyProduct_2ceaa53e-6ad0-350e-8c2b-77078eee2f94|rdf:type|obo:NCIT_C174271 imgt:Product_06bd6f8e-e461-3a5d-a7b7-cafeffa1a18a|imgt:hasStudyProduct|imgt:StudyProduct_74060e28-e11c-3626-96ac-21d736ca7863 imgt:Product_fee013a2-d138-3017-95d6-2f606cb69af6|rdf:type|obo:NCIT_C51980 imgt:9933|imgt:isImgtStructureEntryOf|imgt:mAb_497 imgt:Product_5afec3ec-290b-336b-a08f-33a38d788b45|imgt:isProductOf|imgt:mAb_679 imgt:IgG1-kappa_1090|obo:RO_0002162|imgt:Hum imgt:FAB-GAMMA-3_KAPPA|rdf:type|imgt:StructureLabels _:B5f40d9ad4438db47203808ae4a112619|imgt:hasDesignation|imgt:Orphan_drug imgt:StudyProduct_eba4d4c0-afe2-376f-ab58-cd9ef50a62f9|imgt:isStudyProductOf|imgt:Product_f272da3d-d319-39ce-a72e-2eaf8b604878 imgt:Segment_1149_1|rdf:type|imgt:Segment imgt:mAb_189|imgt:inn_number|10783 imgt:StudyProduct_3b191dcf-99b4-3707-b950-63b947220000|imgt:hasDecision|_:B810b881406ce1ca4eb9fcd40e6a5ab98 imgt:mAb_788|imgt:inn_number|9953 imgt:StudyProduct_f194b2c1-54af-36a1-9743-5293ec4e34ae|rdf:type|obo:NCIT_C174271 imgt:mAb_1235|imgt:hasProduct|imgt:Product_37e454ae-c400-32fb-913e-b064fbf26cc6 imgt:mAb_1009|imgt:inn_number|11303 imgt:mAb_367|imgt:hasProduct|imgt:Product_d34f1ebd-acfa-3151-b703-7247bec7bb83 imgt:mAb_27|imgt:hasMabReceptor|imgt:IgG3-nd_27 imgt:Product_fe91b23e-27cc-3001-95dd-e6bfc387b4ea|rdf:type|obo:NCIT_C51980 imgt:mAb_927|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=927 imgt:StudyProduct_f1a2ac18-78f7-3354-a4a7-44240a5c9472|rdf:type|obo:NCIT_C174271 imgt:mAb_1111|rdf:type|imgt:INN imgt:TNF|obo:RO_0002162|imgt:Homsap imgt:Product_6c67e17c-42f8-38c2-9f6f-6580bc4cf2e7|rdf:type|obo:NCIT_C51980 _:B92504a30cfe849f852803e627551d00f|rdf:type|obo:NCIT_C53285 imgt:IgG1-kappa_633|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:StudyProduct_bfd883d2-e43c-3903-a065-ed4bcf5cd904|imgt:hasClinicalIndication|imgt:Renal_cell_carcinoma_(RCC) imgt:Product_13047200-94f7-35ea-a157-8e8bee74ca78|imgt:hasStudyProduct|imgt:StudyProduct_c8f9c462-3311-34a4-adcf-b7928cf500ac imgt:StudyProduct_00be1b20-3fed-3069-9cf2-70cf839c5138|imgt:hasClinicalPhase|imgt:Phase_II imgt:mAb_827|imgt:inn_recommended_list|79 (2018) imgt:Segment_911_1|rdfs:label|Segment_911_1 imgt:StudyProduct_657ccc33-24fa-3743-a75a-6111c145c586|rdfs:label|StudyProduct_657ccc33-24fa-3743-a75a-6111c145c586 imgt:StudyProduct_89dd9362-e3cb-3733-a657-8b1eb9eefb34|imgt:development_technology| Dual-Affinity Re-targenting (DART®) imgt:Product_2d7e77c3-d14e-30b0-9aab-5d03bcd3b872|imgt:commun_name|LY-CoV555 imgt:11935|rdfs:label|11935 imgt:mAb_661|imgt:inn_recommended_list|77 (2017) imgt:StudyProduct_88a3fab2-d85c-3138-8bbc-f38ba854282c|rdfs:label|StudyProduct_88a3fab2-d85c-3138-8bbc-f38ba854282c _:B5682151c74cf89ff9f21c656141f48d5|imgt:hasStatut|imgt:approval imgt:L-V-J-REGION|rdfs:label|L-V-J-REGION imgt:Segment_931_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:Product_540b3929-a375-3db7-8982-d2f9143d05ad|imgt:isProductOf|imgt:mAb_23 imgt:Product_4e8c6419-bb31-3dc4-81fe-a499fde05f03|rdfs:label|Product_4e8c6419-bb31-3dc4-81fe-a499fde05f03 _:Bee95eff4bc9ae9efa2223b9e7873c257|rdf:type|obo:NCIT_C53285 imgt:StudyProduct_be02faf8-e597-34bc-9ffc-4f885877877a|imgt:hasClinicalPhase|imgt:Phase_I imgt:D-(DJ)-C-CLUSTER|rdfs:label|D-(DJ)-C-CLUSTER imgt:Segment_675_1|rdf:type|imgt:Segment imgt:IgG4-kappa_1148|obo:RO_0002162|imgt:Homsap imgt:mAb_140|imgt:imgt_note| mAb radiolabelled used in radio-immuno-scintigraphy imgt:Hyperlipidemia|rdf:type|obo:NCIT_C185637 imgt:Cancers_breast|imgt:isClinicalIndicationOf|imgt:StudyProduct_69ef2360-5f7b-3ffe-915d-120181a43118 imgt:Construct_486|imgt:isConstructOf|imgt:IgG1-kappa_486 imgt:VH-C-kappa-CH2-CH3_V-lambda-CH1_H-GAMMA-1_L-kappa_793|rdfs:label|VH-C-kappa-CH2-CH3_V-lambda-CH1_H-GAMMA-1_L-kappa_793 imgt:IgG1-lambda_456|rdfs:comment|IgG1 - lambda imgt:IgG4-kappa_1129|http://semanticscience.org/resource/SIO_000291|imgt:IL36RN imgt:Fab-Alpha-1_Kappa|imgt:isDescribedBy|imgt:FAB-ALPHA-1_KAPPA imgt:Segment_787_1|rdf:type|imgt:Segment imgt:INTEGRIN-ALPHA-IIB|skos:definition|integrin chain imgt:IgG1-kappa_297|imgt:hasConstruct|imgt:Construct_297 imgt:Product_499c41a6-6810-367e-b82d-0cab484bef45|rdf:type|obo:NCIT_C51980 imgt:StudyProduct_9aba34e6-9f8d-3df1-82eb-7cbff822726b|rdf:type|obo:NCIT_C174271 imgt:mAb_45|rdfs:label|mAb_45 _:B1d6e1b37175feae542ed65a8371c23cc|imgt:isDecisionOf|imgt:StudyProduct_9ac34664-9570-3c7d-90b6-3eb23cd0e79b imgt:Product_622cce87-f7e3-341c-8969-10865507b3d7|rdfs:label|Product_622cce87-f7e3-341c-8969-10865507b3d7 imgt:Segment_90_1|imgt:has_rank|1 imgt:11904|imgt:isImgtStructureEntryOf|imgt:mAb_1281 imgt:StudyProduct_643fb5f4-6997-38c7-9b26-e1caa4491330|imgt:hasClinicalPhase|imgt:Phase_I/II imgt:StudyProduct_bc0f78e1-839d-311c-93ce-676fbd1ba115|imgt:hasClinicalPhase|imgt:Phase_III imgt:1st-CYS|rdfs:label|1st-CYS imgt:MAbReceptor_514|imgt:isMabReceptorOf|imgt:mAb_514 imgt:Mesothelioma_malignant|imgt:isClinicalIndicationOf|imgt:StudyProduct_ea63c7ae-c264-3520-bdc3-4c0aaee33cf2 imgt:mAb_606|imgt:inn_recommended_list|76 (2016) imgt:Product_3848a1c9-6b90-3def-9542-23d3eaaf0dfe|imgt:isProductOf|imgt:mAb_1211 imgt:%5BV-kappa%5D2-Fc_429|rdfs:comment|[V-kappa]2 - Fc imgt:StudyProduct_a7f358ba-3750-38cd-90ed-282ce24e69fa|rdf:type|obo:NCIT_C174271 imgt:Construct_380|rdf:type|imgt:Construct imgt:C-REGION-UNIT|rdfs:label|C-REGION-UNIT imgt:StudyProduct_6b612b11-5933-3c77-871a-d835dd207209|rdf:type|obo:NCIT_C174271 pubmed:10960454|dc:contributor|Ilan E imgt:CH2-CH3-CH4|rdfs:label|CH2-CH3-CH4 imgt:MAbReceptor_514|rdfs:label|MAbReceptor_514 imgt:mAb_231|imgt:inn_proposed_list|98 (2007) imgt:Product_3fbfe977-f5f9-381b-94d0-489e229f2eaf|imgt:hasStudyProduct|imgt:StudyProduct_6467b730-1f75-3463-aefd-b86721502ab9 imgt:StudyProduct_f9aa0ea1-c550-3cee-b95e-13dd8665a63a|imgt:application_type|Therapeutic _:B1d24c269678a467388e2770285ec20bb|rdf:type|obo:NCIT_C53285 imgt:Nasal_polyposis|imgt:isClinicalIndicationOf|imgt:StudyProduct_a4b72b6a-53ce-3ee3-83c5-d44557866ec1 imgt:L-V-D-J-C-sequence|rdf:type|imgt:Molecule_EntityType imgt:Product_c4c827f8-eb1f-3253-8d37-f5b1a1d56ac7|imgt:hasStudyProduct|imgt:StudyProduct_b11cc987-484a-309d-9ef0-99725f55a76b imgt:Product_37f1c052-5249-3881-9f48-76440121e0dd|imgt:commun_name|8c10 imgt:mAb_288|rdf:type|imgt:INN imgt:StudyProduct_f9fa0669-8698-340e-bafc-63560de1d7cf|rdfs:label|StudyProduct_f9fa0669-8698-340e-bafc-63560de1d7cf imgt:Construct_434|rdf:type|imgt:Construct imgt:mAb_1172|imgt:inn_number|11672 imgt:Anemia_in_chronic_kidney_disease-related_(CKD)|imgt:isClinicalIndicationOf|imgt:StudyProduct_b198d511-4e9d-3483-a5bf-cfa0f9882334 _:B70a187752a81df36925ddb0292913c6b|imgt:hasStatut|imgt:approval imgt:renflexis®|rdfs:comment| RENFLEXIS® (infliximab-abda) developed by Samsung Bioepis (Incheon Korea) commercialized by Merck & Co approved by FDA on April 21 2017 (it is the fifth biosimilar - and second to REMICADE® - approved by FDA press release ). Same clinical indications as REMICADE®. imgt:StudyProduct_e8de6321-19d6-3051-8bd9-c4b71bd85892|imgt:application_type|Therapeutic imgt:Clone_136|obo:RO_0002162|imgt:Musmus imgt:mAb_468|imgt:inn_name|guselkumab imgt:StudyProduct_657ccc33-24fa-3743-a75a-6111c145c586|rdf:type|obo:NCIT_C174271 imgt:mAb_697|imgt:hasProduct|imgt:Product_fc42260f-2c18-39ae-b730-f7c667362547 imgt:StudyProduct_610139e9-1ad4-34aa-99d3-50d54729d262|imgt:development_technology| MorphoSys's HuCAL® phage library imgt:mAb_1275|rdfs:label|mAb_1275 imgt:Product_3e72db9b-e1f8-3042-b36a-b6d976d78dba|imgt:commun_name|HepeX-B™ (combination of exbivirumab and libivirumab) imgt:IgG4-kappa_950|imgt:hasMolecularComponent|imgt:IG imgt:Sickle_Cell_Disease_(SCD)|imgt:clinical_domain|Hematology imgt:StudyProduct_f125f536-cb07-3d41-9944-5fae1929288e|imgt:hasClinicalIndication|imgt:Cancers_gastric imgt:IgG1-kappa-S239C_2cys-drug_866|imgt:hasConstruct|imgt:Construct_866 _:Ba925ee08a37e042c9607cb07b9d36ec3|rdf:type|obo:NCIT_C53285 imgt:VH-CH1-V-LAMBDA-CH1-CH2-CH3|rdfs:label|VH-CH1-V-LAMBDA-CH1-CH2-CH3 imgt:Segment_830_1|imgt:hasImgtLabel|imgt:GCG_analog imgt:FAB-DELTA_KAPPA|rdfs:label|FAB-DELTA_KAPPA imgt:IgG1-lambda2|rdf:type|imgt:SegmentLabels imgt:IgG1-kappa-4cys-drug_1155|imgt:hasMolecularComponent|imgt:IG imgt:Segment_1186_1|rdfs:label|Segment_1186_1 imgt:IgG1-kappa-4lys-drug_58|obo:RO_0002162|imgt:Hum imgt:StudyProduct_4cfdf2ec-f342-3054-9bde-f57fcde70b5d|imgt:hasClinicalIndication|imgt:Cancers_esophageal_resectable imgt:StudyProduct_5d076d22-d8f6-3d55-aaef-4662e6ea97f4|imgt:isStudyProductOf|imgt:Product_bfa250a2-4d83-369c-923c-0638ab4c386d imgt:10263|imgt:isImgtStructureEntryOf|imgt:mAb_645 imgt:StudyProduct_2ddd81e8-eba0-36ff-b70b-d8f066a71cc9|imgt:hasClinicalPhase|imgt:Phase_M imgt:Intracranial_hemorrhage_(ICH)|rdfs:label|Intracranial_hemorrhage_(ICH) imgt:Type_2_diabetes_(T2_DM)|imgt:clinical_domain|Immunology imgt:10940|imgt:isImgtStructureEntryOf|imgt:mAb_966 imgt:mAb_256|imgt:inn_recommended_list|55 (2006) imgt:IgG1-nd_184|rdfs:comment|IgG1 - nd imgt:Cardiac_myxoma|imgt:isClinicalIndicationOf|imgt:StudyProduct_4ff3791f-430a-396c-b7dc-38fd60a2e83a imgt:StudyProduct_f547fd7a-6818-32ba-9a06-1c2e72c78fdf|imgt:hasClinicalIndication|imgt:Cancers imgt:StudyProduct_4bf71638-3473-3ec8-aad8-2660c8cb6487|imgt:isStudyProductOf|imgt:Product_c8390c36-6b3e-3a6e-bce0-3d7d542ca6fe imgt:mAb_714|imgt:hasProduct|imgt:Product_d38d61b1-643a-33d9-9785-f4b0aad161ed _:B56a14cf71b8806e2a74d2fb7af6cd68e|imgt:isDecidedBy|imgt:FDA imgt:StudyProduct_cd465abe-06a6-3a1f-a763-135f99c56841|rdfs:label|StudyProduct_cd465abe-06a6-3a1f-a763-135f99c56841 imgt:StudyProduct_edecf533-0f48-3169-b1b6-54b81c7e8009|rdfs:label|StudyProduct_edecf533-0f48-3169-b1b6-54b81c7e8009 imgt:LRR15|skos:definition|Leucine-rich repeat imgt:Product_dbe70051-84bf-318e-a2df-870d1dbb932a|imgt:hasStudyProduct|imgt:StudyProduct_b0068f1c-09c6-31a5-a114-bad6096c12c7 _:Bbd3f7b033bc730c9d2d35615de62b6aa|imgt:isDecisionOf|imgt:StudyProduct_1488a7ea-5fe0-3ac3-a8a3-82aeca5bfbac imgt:Segment_702_2|rdf:type|imgt:Segment imgt:StudyProduct_75b6a2b5-b839-3dba-a5e9-a51e3ee069fc|rdf:type|obo:NCIT_C174271 obo:NCIT_C20495|rdfs:subClassOf|obo:NCIT_C1909 _:Baef4a3ce929c8e0acdfcd85b6ab46482|imgt:hasStatut|imgt:approval imgt:StudyProduct_cddea082-ad7a-3329-9666-85104cd4f3b2|rdfs:label|StudyProduct_cddea082-ad7a-3329-9666-85104cd4f3b2 imgt:J-MOTIF|rdf:type|imgt:SequenceLabels imgt:Product_20fcba1e-a0bb-3838-8745-6c6f5da541f2|imgt:isProductOf|imgt:mAb_354 imgt:StudyProduct_c8f9c462-3311-34a4-adcf-b7928cf500ac|rdfs:label|StudyProduct_c8f9c462-3311-34a4-adcf-b7928cf500ac imgt:StudyProduct_7203423a-8a25-3a39-963b-82f12d06aea0|imgt:application_type|Therapeutic imgt:isOrderedIn|rdfs:domain|imgt:Gene _:B962f24c63ef3479c302471fe76ef9c4b|imgt:hasStatut|imgt:approval imgt:StudyProduct_fb299b3f-f4d1-3b52-8f3a-47cc96451ce5|rdfs:label|StudyProduct_fb299b3f-f4d1-3b52-8f3a-47cc96451ce5 imgt:StudyProduct_f1f705eb-d8fa-3012-b6f9-e7c7bd71e8af|imgt:application_type|Therapeutic imgt:mAb_138|imgt:inn_proposed_list|67 (1992) imgt:VH-V-KAPPA-VH-V-LAMBDA|skos:definition|Chain comprising a V-KAPPA,V-LAMBDA a VH domains imgt:Five_Prime_Therapeutics_Inc|imgt:produces|imgt:Product_96fc911e-455e-31e8-853b-3466ad4672d0 imgt:mAb_1206|imgt:inn_recommended_list|87 (2022) imgt:Product_33c4e35a-e84b-3619-8100-ef4640624541|rdf:type|obo:NCIT_C51980 imgt:Construct_1201|imgt:isConstructOf|imgt:IgG1-lambda_1201 imgt:Fab-Alpha_Lambda|imgt:isDefinedBy|imgt:IG-Light-Lambda-IGL _:B284beb791538b6a82503002e3ba2edb0|imgt:hasDesignation|imgt:Orphan_drug imgt:Product_010eb41e-d503-390b-825c-4077f0fe83bd|imgt:isProducedBy|imgt:ImmunoGen_Inc imgt:Product_20a3f071-ad32-3ce5-bf2d-1658fb45f799|rdf:type|obo:NCIT_C51980 imgt:StudyProduct_b24a52d0-d5eb-3d05-8c5c-5515dea60f18|imgt:application_type|Therapeutic imgt:mAb_331|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=331 imgt:Product_c67d4f68-56c4-3c24-8eaa-730b7fd45aaf|imgt:hasStudyProduct|imgt:StudyProduct_34235bce-3bdc-381d-afe4-251c5a169db0 imgt:StudyProduct_5213ac74-1389-31f3-888c-adb13fdebaec|imgt:isStudyProductOf|imgt:Product_32616388-2f3b-3bc7-9429-693216dd67ab imgt:Product_c299e202-690b-3ffc-8c53-e45056548ad0|imgt:isProductOf|imgt:mAb_146 imgt:Kidney_transplantation_treatment_of_antibody-mediated_rejection_(AMR)|rdf:type|obo:NCIT_C185637 imgt:Neuromyelitis_optica_(NMO)|imgt:isClinicalIndicationOf|imgt:StudyProduct_99437481-72fe-3999-af98-dd27259f1f62 imgt:Product_ccaee58d-d4c1-3c86-90f0-df9bb7bf2ae1|imgt:hasStudyProduct|imgt:StudyProduct_50d40cdb-5c10-3536-957a-9803d78451f5 imgt:Construct_776|rdfs:label|Construct_776 imgt:StudyProduct_d4930ea7-e483-3038-bacf-0735e7e036b9|imgt:hasClinicalPhase|imgt:Phase_II obo:NCIT_C175177|rdfs:subClassOf|obo:NCIT_C1909 imgt:Synovial_sarcoma|imgt:clinical_domain|Oncology imgt:StudyProduct_3285d699-b694-3b33-b63d-0692bc62e613|imgt:application_type|Therapeutic imgt:Solid_tumors|imgt:isClinicalIndicationOf|imgt:StudyProduct_55a04cf0-16f2-3eaf-b39b-9ada369330da imgt:StudyProduct_7a96fb44-bee0-36fc-89c4-dfaffc85aa16|imgt:hasExpressionSystem|imgt:_Tobacco_plant_Nicotiana_benthamiana imgt:Product_2fe9dc72-d473-3067-9bd5-11392ca71f36|imgt:commun_name|faricimab-svoa obo:NCIT_C123828|rdfs:subClassOf|obo:NCIT_C1909 imgt:Product_e46175a9-7b80-3dd9-b1b9-e9ff16e327c0|imgt:hasStudyProduct|imgt:StudyProduct_d091cbc1-ec15-35b2-965b-160c2b908d77 imgt:StudyProduct_d2e57127-b131-3441-881d-1f8e65a7880d|imgt:isStudyProductOf|imgt:Product_972e9945-c489-3173-8e5c-a341bfd8de2d imgt:IGHG2|rdf:type|imgt:SegmentLabels _:B896840c02032358f107d9a350da23b4c|rdf:type|obo:NCIT_C53285 pubmed:15994800|imgt:isBibliographicReferenceOf|imgt:mAb_90 imgt:Lymphoma|imgt:isClinicalIndicationOf|imgt:StudyProduct_53bc7d93-ee19-3044-a1b4-9aff91b5dc3d imgt:Segment_1227_2|rdf:type|imgt:Segment imgt:StudyProduct_52d64598-ed50-3201-a067-7767d7a82e62|rdf:type|obo:NCIT_C174271 imgt:Fab-Alpha_Lambda|rdfs:label|Fab-Alpha_Lambda imgt:IgG1-kappa_1122|rdf:type|imgt:MAbReceptor imgt:mAb_132|rdfs:label|mAb_132 imgt:mAb_182|imgt:inn_recommended_list|45 (2001) imgt:mAb_477|imgt:inn_proposed_list|108 (2012) imgt:Clone_28|rdf:type|obo:NCIT_C37925 imgt:12104|imgt:isImgtStructureEntryOf|imgt:mAb_1263 imgt:StudyProduct_9b3dd0f9-56f2-3a5d-9452-a0310c985e83|rdf:type|obo:NCIT_C174271 imgt:IgG1-kappa_231|obo:RO_0002162|imgt:Hum imgt:mAb_392|imgt:hasProduct|imgt:Product_f13441d6-24fa-3bbd-8cf9-c42aef37f1b1 imgt:mAb_856|imgt:clinical_trials|7 studies found, 4 recruiting imgt:HOR-CTP_697|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/HOR-CTP.png imgt:Segment_1210_1|imgt:has_rank|1 imgt:Rheumatoid_arthritis_(RA)|imgt:isClinicalIndicationOf|imgt:StudyProduct_ed93c1fc-3057-3d2e-be34-06ab0de17375 imgt:Segment_1258_2|rdf:type|imgt:Segment imgt:Product_d50fe58f-9435-33aa-a2dd-cdb13c40f840|imgt:commun_name|SAND 26 imgt:IgG1-kappa-2cys-CH3_879|imgt:via_a| cleavable maleimidocaproyl-valyl-citrullinyl-p-aminobenzyloxycarbonyl (mc-val-cit-PABC) type linker imgt:mAb_167|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=167 imgt:StudyProduct_7d100d5a-05e0-3ffb-ad07-68ea0a7560bd|rdf:type|obo:NCIT_C174271 imgt:mAb_271|imgt:hasMabReceptor|imgt:IgG1-nd_271 imgt:4JN2|rdf:type|obo:NCIT_C25402 imgt:Segment_1051_1|imgt:has_rank|1 imgt:Product_e21dd8f0-fd23-3229-b28c-877b1bfea25c|imgt:hasStudyProduct|imgt:StudyProduct_e1aeee3d-eae9-3c02-9116-81d29cbc7440 imgt:StudyProduct_312f2ba0-98d0-32ad-a11c-c2802aa7e886|imgt:isStudyProductOf|imgt:Product_5c04be23-e79a-3cda-a452-c8c13a5d1811 obo:NCIT_C102758|rdf:type|owl:Class imgt:Segment_495_1|imgt:has_rank|1 imgt:Segment_49_1|rdf:type|imgt:Segment imgt:Construct_464|obo:BFO_0000051|imgt:Segment_464_1 imgt:Product_9714b306-6ce1-3c30-b822-479b49ca52de|imgt:isProducedBy|imgt:CytomX_Therapeutics_Inc imgt:Product_bfa250a2-4d83-369c-923c-0638ab4c386d|rdf:type|obo:NCIT_C51980 imgt:mAb_721|imgt:hasProduct|imgt:Product_58a44815-3c5a-344f-960b-2c9d9ab2ae6d imgt:IgG1-kappa_907|imgt:hasConstruct|imgt:Construct_907 imgt:StudyProduct_aabc1dbf-d867-375e-afb7-86af5e065011|imgt:isStudyProductOf|imgt:Product_05e5be80-e208-3f76-b968-e0554e88cdc8 imgt:remsima™|rdfs:label|REMSIMA™ imgt:Product_97d744b1-4bb8-3b77-b6fc-10c38a6bca9a|imgt:isProductOf|imgt:mAb_429 imgt:StudyProduct_9801dc10-1bf3-3726-94d1-aaa04acece27|imgt:application_type|Therapeutic imgt:StudyProduct_075ec1e2-8d05-38ec-9c70-b0a617ebdee8|imgt:application_type|Therapeutic imgt:Product_19035bc7-8361-3721-af18-5bc56c99124d|rdfs:label|Product_19035bc7-8361-3721-af18-5bc56c99124d imgt:mAb_313|rdfs:label|mAb_313 pubmed:10561020|dc:contributor|Varns C imgt:StudyProduct_1bb64584-3372-35f4-979c-739fd455f8fe|imgt:isStudyProductOf|imgt:Product_538ab0c9-c52c-3c61-ae4c-1c89532b23a7 imgt:StudyProduct_ea189e94-52bf-3ada-9202-208f164eaee5|imgt:hasDecision|_:B6821522f6d0858e86795e3ccb5f5d0e2 imgt:J-transcript|skos:definition|Identifies, for mRNA, molecule entities with a germline J region. J-transcript is in germline configuration. imgt:IG-Heavy-Xi|imgt:hasChainTypeLevel|imgt:IG-Heavy pubmed:15994800|dc:contributor|Backus HH imgt:Clone_558|obo:RO_0002162|imgt:Musmus imgt:Hypertriglyceridemia|imgt:clinical_domain|Cardiovascular diseases imgt:StudyProduct_b829a309-e928-324b-a2e8-57ebcf7be032|imgt:isStudyProductOf|imgt:Product_a628c2c8-e5e7-35d3-8b9c-3f3c81705040 imgt:Cancers_brain_metastatic|rdfs:label|Cancers_brain_metastatic imgt:Product_be1e1fa6-d1b4-3e28-895d-c50bd4460c4a|imgt:hasStudyProduct|imgt:StudyProduct_15d341a9-fce9-3f04-ba43-7569997016af imgt:10562|rdfs:label|10562 imgt:StudyProduct_337c97f1-fee5-35a1-a552-4d1e6dcc3d63|imgt:hasClinicalPhase|imgt:Phase_I imgt:StudyProduct_af1bf769-285d-3a3e-b8ab-7b4988d6ea1c|rdf:type|obo:NCIT_C174271 obo:NCIT_C152582|rdf:type|owl:Class imgt:Segment_795_1|obo:BFO_0000050|imgt:Construct_795 imgt:mAb_1299|rdf:type|obo:NCIT_C1909 imgt:IgG1-nd_MM_309|rdfs:label|IgG1-nd_MM_309 imgt:Construct_769|rdfs:label|Construct_769 imgt:Ex_vivo_treatment_of_autologous_bone_marrow_and_subsequent_reinfusion|imgt:isClinicalIndicationOf|imgt:StudyProduct_80d5f865-42ca-36ec-ae6c-8de6597f077f imgt:TNFSF18|rdf:type|imgt:SegmentLabels imgt:INIT-CODON|rdfs:label|INIT-CODON imgt:StudyProduct_3a53c671-727d-3a24-b885-62ab36cd6573|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_771b0a00-f57f-38d5-885c-8702cdc4acd2|imgt:isStudyProductOf|imgt:Product_5c704ad4-2680-304a-a836-b24fbaa6e9d1 imgt:(scFv-heavy-kappa)-(scFv-heavy-lambda)_838|rdfs:comment|(scFv - heavy - kappa) - (scFv - heavy - lambda) imgt:mAb_417|rdf:type|imgt:INN imgt:StudyProduct_c1f4369b-0842-3002-b808-9913ae773a47|rdf:type|obo:NCIT_C174271 imgt:Product_537aaf49-2c7a-3981-8bd7-5b72ab2e0fb9|imgt:hasStudyProduct|imgt:StudyProduct_454fa2ab-d4ad-3680-9760-9da2d95eb36a imgt:mAb_1230|imgt:hasMabReceptor|imgt:scFv-heavy-kappa-CD8A_(CO-TM)-TNFRSF9_(CY)-CD247_1230 imgt:mAb_371|rdf:type|imgt:INN imgt:CytoDyn_Inc|rdfs:comment|Vancouver , USA imgt:Product_0567c1ec-d5f6-3399-831e-5021d15e29be|imgt:hasStudyProduct|imgt:StudyProduct_85864ad3-8f09-311e-8dd6-1b36987160d2 imgt:Segment_787_1|imgt:has_rank|1 imgt:mAb_711|imgt:inn_recommended_list|18 (1978) imgt:IgG4-kappa_642|imgt:hasConstruct|imgt:Construct_642 _:Bf91fa1bf5f020b071bebc5f8e869f319|rdf:type|obo:NCIT_C53285 imgt:StudyProduct_880048e4-140b-39df-8cc2-288ca967d860|imgt:hasClinicalPhase|imgt:Phase_M imgt:StudyProduct_96a85267-79e5-38bd-a186-3eff727e5d32|imgt:application_type|Therapeutic imgt:StudyProduct_a9bbcdc9-dd80-3727-9554-cafb62b18319|rdfs:label|StudyProduct_a9bbcdc9-dd80-3727-9554-cafb62b18319 imgt:mAb_21|rdf:type|imgt:INN imgt:Construct_723|rdf:type|imgt:Construct imgt:5ID1|rdf:type|obo:NCIT_C25402 imgt:mAb_38|imgt:hasOriginClone|imgt:Clone_38 imgt:IgG1-lambda_1199|rdf:type|imgt:MAbReceptor imgt:Clone_1190|rdfs:label|Clone_1190 _:B5b1e13e710f9af840e6632ebc6edb71e|imgt:isDecidedBy|imgt:FDA _:B5b2a64551ee0ebcae056426b0edcf622|imgt:hasDesignation|imgt:Orphan_drug imgt:Polymyalgia_Rheumatica_(PMR)|imgt:clinical_domain|Rheumatology imgt:IgM-nd_8|imgt:isMabReceptorOf|imgt:mAb_8 obo:NCIT_C155967|rdf:type|owl:Class imgt:Fab-Gamma-3_Kappa|imgt:isDefinedBy|imgt:IG-Heavy-Gamma-3-IGHG3 imgt:scFv-kappa-heavy-IGHG4_h_(CO)-CD28_(TM)-TNFRSF9_(CY)_CD247-TEApep-EGFRt_1099|imgt:hasConstruct|imgt:Construct_1099 imgt:Rheumatoid_arthritis_(RA)|imgt:isClinicalIndicationOf|imgt:StudyProduct_3af4fc94-a470-31a6-b10b-f0a9c38ec2f9 imgt:Seattle_genetics_Inc|imgt:produces|imgt:Product_5361ee36-3770-3139-a6be-27e3520b6392 imgt:Segment_412_1|imgt:has_rank|1 imgt:StudyProduct_b36be4d6-3071-3bfa-abcf-f2432acdd175|rdfs:label|StudyProduct_b36be4d6-3071-3bfa-abcf-f2432acdd175 imgt:11672|rdf:type|obo:NCIT_C25402 imgt:mAb_971|imgt:inn_recommended_list|83 (2020) imgt:CPCA_PROTEIN_BIG-FC_521|imgt:isMabReceptorOf|imgt:mAb_521 imgt:mAb_485|imgt:inn_name|bococizumab imgt:IgG1-kappa_406|imgt:hasMolecularComponent|imgt:IG imgt:StudyProduct_b8a47dda-26fa-391b-97e6-2b21143896ff|rdfs:label|StudyProduct_b8a47dda-26fa-391b-97e6-2b21143896ff imgt:StudyProduct_2a973a1a-e37f-35eb-9dc5-08529b842cc7|imgt:hasClinicalIndication|imgt:Rheumatoid_arthritis_(RA) imgt:B_cell_acute_lymphoblastic_leukemia_(B_cell_ALL)|rdfs:label|B_cell_acute_lymphoblastic_leukemia_(B_cell_ALL) imgt:IgG1-kappa_925|rdfs:comment|IgG1 - kappa imgt:mAb_452|imgt:inn_name|nesvacumab imgt:StudyProduct_fcd0ae2d-ba63-3382-af10-acc1fc95fa9b|imgt:hasClinicalPhase|imgt:Phase_I imgt:Cancers_pancreatic|imgt:isClinicalIndicationOf|imgt:StudyProduct_6d87d57d-9799-326e-aa32-a570c9033bac imgt:Construct_1216|rdf:type|imgt:Construct imgt:Cambridge_Antibody_Technology|imgt:produces|imgt:Product_e9725593-72db-3005-b841-06e3fc3b71a1 imgt:IgG1-kappa-4cys-drug_478|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa-4cys-drug.png imgt:StudyProduct_8ab0cbdb-f678-31f5-91be-903e72d11550|rdfs:label|StudyProduct_8ab0cbdb-f678-31f5-91be-903e72d11550 imgt:Segment_475_1|imgt:hasImgtLabel|imgt:FZD8 imgt:IgG4-kappa_1184|rdfs:comment|IgG4 - kappa imgt:Clone_124|rdfs:label|Clone_124 _:B11fd41f41ead1532b4c3b5f39a7db635|dc:date|1998-09-25 imgt:IgG4-kappa_1010|obo:RO_0002162|imgt:Hum _:Bba3614d0fab02906dcb369ce0a03a7b9|imgt:isDecidedBy|imgt:FDA imgt:mAb_248|imgt:inn_number|8716 _:B9d32b556122c7c0afb3b42d8159cbe26|imgt:isDecidedBy|imgt:FDA imgt:Center_of_Molecular_Immunology_(CMI)|imgt:produces|imgt:Product_b7a7e4bb-f8f0-300e-9c56-2377c788b72a imgt:Product_98a40d96-4f45-305e-ab3e-b032a15f3eef|imgt:isProducedBy|imgt:Cadila_Healthcare imgt:mAb_707|imgt:inn_proposed_list|48 (1982) imgt:Product_4d3e419a-89b3-3235-9f0f-4e098837e002|imgt:isProducedBy|imgt:Sorin_Radiofarmaci_SRL imgt:StudyProduct_aed03555-8c35-37f3-9604-74b051e88b63|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_26e3d6fe-21a9-346c-aec2-a42a0df1ec22|imgt:hasClinicalPhase|imgt:Phase_II imgt:StudyProduct_636146a7-faa7-30f7-9b23-dd784755dacc|imgt:hasClinicalIndication|imgt:Factor_VII_deficiency_(treatment_of_bleeding_episodes) imgt:mAb_830|rdfs:label|mAb_830 imgt:Renal_mass|imgt:isClinicalIndicationOf|imgt:StudyProduct_d00758a4-9bbb-30b2-ba22-ba17e1ead7c0 imgt:mAb_854|imgt:inn_name|orilanolimab imgt:mAb_194|imgt:hasProduct|imgt:Product_4eeaa614-ef03-3234-84a9-d2d1c82a6455 imgt:PSCA|skos:definition|PSCA (prostate stem cell antigen) imgt:Segment_901_1|imgt:hasImgtLabel|imgt:Fab-G1-kappa _:B224cb7f2b58146ce0e3ef5cf987b651a|imgt:isDecidedBy|imgt:FDA imgt:IgG4-kappa_1174|imgt:hasConstruct|imgt:Construct_1174 imgt:Hodgkin_lymphoma|rdf:type|obo:NCIT_C185637 imgt:Construct_271|imgt:isConstructOf|imgt:IgG1-nd_271 imgt:StudyProduct_ec41c831-5a12-3940-835f-540bd8464ab2|imgt:application_type|Therapeutic imgt:mAb_1012|imgt:clinical_trials|3 studies found, 3 recruiting imgt:Laboratoire_Français_du_fractionnement_et_des_Biotechnologies_(LFB)|imgt:produces|imgt:Product_02b59103-6c16-3f49-8566-9f32613c7471 imgt:StudyProduct_ffef88d6-739a-374e-828d-ad5eee20ab3e|imgt:application_type|Therapeutic imgt:%5BscFv%5D2-Fc-%5BscFv%5D2_580|http://semanticscience.org/resource/SIO_000291|imgt:FOLH1 imgt:IgG4-kappa_1241|obo:RO_0002162|imgt:Hum imgt:Product_eb6a1c8e-f445-3794-a73f-0451f26bb760|imgt:hasStudyProduct|imgt:StudyProduct_093b9da8-554b-37e8-b370-9f89231d1d46 imgt:StudyProduct_8a6affb8-2186-34a2-89d8-78314af8f13c|imgt:hasClinicalIndication|imgt:Progressive_supranuclear_palsy_(PSP) imgt:10149|rdf:type|obo:NCIT_C25402 imgt:MAbReceptor_63|rdf:type|imgt:MAbReceptor imgt:StudyProduct_4685e4b0-f92f-33c1-8d24-b664837e74a6|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:Lymphoma_splenic_marginal_zone_(SMZL)|imgt:isClinicalIndicationOf|imgt:StudyProduct_a09e5568-bd9c-33ea-9c33-96045e4ad78b imgt:Construct_98|rdf:type|imgt:Construct imgt:mAb_1288|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=1288 imgt:StudyProduct_e7c6b873-2c73-3203-995c-51b2cc2aaea6|imgt:hasClinicalPhase|imgt:Phase_III imgt:Construct_867|imgt:isConstructOf|imgt:IgG1-kappa_867 imgt:StudyProduct_30086b40-1961-324c-b4da-8f5853b139be|rdf:type|obo:NCIT_C174271 imgt:Alcon_Laboratories_Inc|imgt:produces|imgt:Product_e0278568-febe-37ab-bbd2-9027ac7db7e5 _:Bb367c48edd43b9508eec21aafd4e6617|rdf:type|obo:NCIT_C53285 imgt:Product_19f07e32-1fd4-373c-81f7-b705421b88b4|imgt:isProductOf|imgt:mAb_520 imgt:Construct_405|imgt:isConstructOf|imgt:(scFv-kappa-heavy)-(scFv-heavy-kappa)_405 imgt:FUSION-F8-GAMMA1|rdfs:label|FUSION-F8-GAMMA1 imgt:StudyProduct_89a7f282-c155-362c-89f9-8467980d2e13|imgt:hasDecision|_:B0c3c4584ef01a1138a4379f51770fd70 imgt:Segment_301_1|obo:BFO_0000050|imgt:Construct_301 imgt:Product_6d63f69d-a1ca-3149-b100-1dcdac1888cd|imgt:commun_name|XmAb-22841 imgt:scFv-kappa-heavy-CD8A_(CO-TM)-TNFRSF9_(CY)-CD247_828|rdfs:label|scFv-kappa-heavy-CD8A_(CO-TM)-TNFRSF9_(CY)-CD247_828 imgt:tetravalent|imgt:isTargetOf|imgt:IgG4-kappa-%5BscFv%5D2_776 imgt:StudyProduct_4eb26815-b8de-3cc1-99ea-3b5008556527|rdfs:label|StudyProduct_4eb26815-b8de-3cc1-99ea-3b5008556527 imgt:Acute_myeloid_leukemia_(AML)|imgt:isClinicalIndicationOf|imgt:StudyProduct_2f2dfbd2-681b-377f-b249-f5278e49229b imgt:IgG1-kappa_860|rdfs:label|IgG1-kappa_860 imgt:isProductOf|rdfs:label|isProductOf imgt:Product_3e95582f-d686-389a-b368-f68cabf00d88|imgt:isProductOf|imgt:mAb_1275 imgt:IgG1-kappa_MM_115|imgt:radiolabelled_with| Indium-111, In-111 imgt:Product_7ce9196a-555d-310a-97a0-5462869c1f74|rdfs:label|Product_7ce9196a-555d-310a-97a0-5462869c1f74 imgt:Segment_533_1|rdf:type|imgt:Segment obo:NCIT_C53285|rdfs:label|Decision imgt:Construct_618|rdf:type|imgt:Construct imgt:mAb_684|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=684 imgt:IgG1-kappa_263|rdf:type|imgt:MAbReceptor imgt:StudyProduct_ceb7772c-4230-3f78-9b92-e823888f62fb|rdf:type|obo:NCIT_C174271 _:Bba3614d0fab02906dcb369ce0a03a7b9|rdf:type|obo:NCIT_C53285 imgt:mAb_1143|rdf:type|obo:NCIT_C156705 _:B4103f5cbd4051fba6a90b669b74496e1|imgt:isDecisionOf|imgt:StudyProduct_fb049423-02a4-3c71-b284-29932cb38182 imgt:mAb_737|rdf:type|imgt:INN imgt:mAb_549|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=549 imgt:mAb_603|imgt:hasProduct|imgt:Product_6046a785-1f37-30d3-8151-7ba14caa56ee imgt:StudyProduct_20176e48-84e8-3a6b-b2b8-ab0c782c868a|rdfs:label|StudyProduct_20176e48-84e8-3a6b-b2b8-ab0c782c868a imgt:StudyProduct_49e8d5cc-d97b-3254-9441-7552e198c97d|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_80cc923e-ef63-348c-ac5b-d5fffb82ada1|rdfs:label|StudyProduct_80cc923e-ef63-348c-ac5b-d5fffb82ada1 imgt:StudyProduct_db6e4f8b-4477-3045-a47e-44e4aeaf8403|imgt:hasClinicalIndication|imgt:Colitis_ulcerative_(UC) _:Bb1650d90e3379663c73b15c8fd192eff|rdf:type|obo:NCIT_C53285 imgt:mAb_742|imgt:clinical_trials|9 studies found, 1 recruiting imgt:IgG2-kappa_376|rdf:type|imgt:MAbReceptor imgt:_NS0_mouse_myeloma_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_05ddb4d2-a6fb-3832-9fe2-3592ea8df038 imgt:Product_9c4af3d6-17e7-3e32-a5c5-0668ad3df256|rdf:type|obo:NCIT_C51980 imgt:G-ALPHA1-ALPHA2-LIKE|rdfs:label|G-ALPHA1-ALPHA2-LIKE imgt:Product_595f5bf0-a48b-356e-b374-0db449f1b3ab|rdf:type|obo:NCIT_C51980 imgt:Product_c10a43ba-cfd6-3610-84b1-dabd23fd8ede|imgt:isProducedBy|imgt:ImmunoGen_Inc imgt:Surface_Oncology_Inc|rdfs:comment|null , USA imgt:Cancers_lung|imgt:isClinicalIndicationOf|imgt:StudyProduct_a038f980-d395-3ef6-983a-e845316292be imgt:Segment_141_1|imgt:hasImgtLabel|imgt:F(ab)2_Fab/Fab2_mix imgt:StudyProduct_d8e204cf-0765-3d39-afdc-63016aeb34ef|imgt:hasClinicalIndication|imgt:Macular_edema_following_Retinal_Vein_Occlusion_(RVO) imgt:Product_f0c3d7ec-73fc-3e13-804c-c87d05009d94|imgt:hasStudyProduct|imgt:StudyProduct_eb7704fc-d825-3975-9e65-ca24023cad33 imgt:FPIA_FC-%5BPEPTIDE%5D2_1164|obo:RO_0002162|imgt:Homsap imgt:Product_b7bee7b5-34bb-3282-9b4f-2678b12b5b39|imgt:commun_name|CYT-356-Y-90 imgt:Cambridge_Antibody_Technology|imgt:produces|imgt:Product_73e808f7-90e0-31f3-b3df-331959c5081c imgt:TSLP|imgt:isTargetOf|imgt:IgG2-lambda_573 imgt:StudyProduct_0485cef8-ac82-346b-aa36-ae9f4bdb7da9|imgt:application_type|Therapeutic imgt:Product_22e71cb5-4fe7-3627-8a07-360ee7654a02|imgt:commun_name|RO0503821 imgt:Segment_593_1|imgt:has_rank|1 imgt:StudyProduct_91667898-e331-3f72-aafb-77e31f239f70|rdfs:label|StudyProduct_91667898-e331-3f72-aafb-77e31f239f70 imgt:StudyProduct_d650f565-00b1-3d82-9f7c-92afedb5794c|imgt:application_type|Therapeutic imgt:L-LAMBDA|imgt:describes|imgt:IG-Light-Lambda-IGL imgt:11173|rdf:type|obo:NCIT_C25402 imgt:StudyProduct_28790f9e-30be-3e9c-b827-69ba060ccb1e|imgt:isStudyProductOf|imgt:Product_13047200-94f7-35ea-a157-8e8bee74ca78 imgt:Product_4c11ab27-05af-3a09-8d86-91e6154e14c1|rdf:type|obo:NCIT_C51980 imgt:FPIA_%5BPROTEIN%5D2-FC_1048|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/FPIA_[PROTEIN]2-FC.png imgt:scFv-kappa-heavy-CD28_(CO-TM-CY)-CD247_1233|obo:RO_0002162|imgt:Chi imgt:TR-Beta-1-TRBC1|imgt:isDescribedBy|imgt:TR-BETA-1 _:B0e3b340eacf1995f92a904cf5f1847f1|dc:date|2011-03-10 imgt:IgG4-kappa_948|http://semanticscience.org/resource/SIO_000291|imgt:LAG3 imgt:mAb_997|imgt:inn_recommended_list|82 (2019) imgt:mAb_1253|imgt:hasOriginClone|imgt:Clone_1253 imgt:IgG1-kappa-%5BscFv-heavy-kappa%5D2|rdf:type|imgt:ConstructLabels imgt:mAb_169|imgt:inn_name|tuvirumab imgt:Product_9513f6a4-618a-3644-ad7a-e9451f9f3e57|imgt:commun_name|SC-003 imgt:Construct_817|imgt:isConstructOf|imgt:IgG1-kappa_817 imgt:Product_2baba1ed-1fb0-315f-a829-937a1ea0335b|imgt:hasStudyProduct|imgt:StudyProduct_6582d769-9c69-384d-bb0e-609d2fa12d2d imgt:mAb_1055|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=1055 imgt:Product_ec237639-f7f0-317a-873c-3d63fc3e8da1|imgt:hasStudyProduct|imgt:StudyProduct_a7a67e43-7d13-32e5-9da3-93ac0b5d6a4f imgt:F(ab%27)2-G1-kappa-PROT_906|imgt:fused_with| Homo sapiens GAA (glucosidase alpha, acid, lysosomal alpha-glucosidase) (Pr67-952) (1:2) Enzyme substitute imgt:Fab%27-G1-nd|rdf:type|imgt:ConstructLabels imgt:StudyProduct_055763d5-3aa1-3bf6-9341-dc2da74f7261|rdf:type|obo:NCIT_C174271 imgt:ConstructLabels|rdf:type|owl:Class imgt:StudyProduct_629d4aff-1483-3f88-bf03-a1d3ebc3a37e|imgt:hasClinicalPhase|imgt:Phase_II imgt:StudyProduct_5a5c7b16-1104-3817-8817-64e9caa4b33b|imgt:hasClinicalPhase|imgt:Phase_II imgt:INTEGRIN-ALPHA-X|rdfs:label|INTEGRIN-ALPHA-X imgt:IgG1-kappa_92|imgt:hasConstruct|imgt:Construct_92 imgt:PROTEIN_1DOMAIN-PEG_637|http://semanticscience.org/resource/SIO_000291|imgt:IFNAR2 pubmed:1279672|dc:contributor|Barbas C.F.III. imgt:Construct_732|obo:BFO_0000051|imgt:Segment_732_2 imgt:StudyProduct_df3389d7-4deb-31c5-98de-7417e117509c|imgt:hasClinicalIndication|imgt:Cancers_ovarian imgt:mAb_467|imgt:inn_proposed_list|109 (2013) imgt:Asthma|imgt:isClinicalIndicationOf|imgt:StudyProduct_939b3314-6b35-370e-aadb-30c09a6e28f6 imgt:mAb_1028|imgt:inn_proposed_list|122 (2019) imgt:MRC_Technology|imgt:produces|imgt:Product_2d6dc8ac-2515-36a9-93a9-593bb22899a0 imgt:IgG1-kappa_151|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa.png imgt:StudyProduct_c959e43a-2545-3a0e-a9d2-28ecca63ff2a|imgt:hasClinicalPhase|imgt:Phase_II pubmed:2480605|dc:contributor|Chaudhary VK _:B18581847083d09f8a1f0205124c681af|imgt:isDecidedBy|imgt:FDA imgt:StudyProduct_fb299b3f-f4d1-3b52-8f3a-47cc96451ce5|rdf:type|obo:NCIT_C174271 imgt:Construct_382|obo:BFO_0000051|imgt:Segment_382_1 imgt:mAb_201|imgt:inn_number|8298 imgt:StudyProduct_49da4a97-7e26-3138-8135-9bd4fc348fd1|imgt:hasClinicalIndication|imgt:Pain_chronic imgt:KIRD2_subgroup|imgt:isTargetOf|imgt:IgG4-kappa_423 imgt:StudyProduct_c0856ed2-bad7-3465-bfe1-2e0629159dc4|imgt:application_type|Therapeutic imgt:PDGFRB|obo:RO_0002162|imgt:Homsap imgt:Product_6a1f5927-c36a-33fe-aaad-a8f6cfeca910|imgt:commun_name|97 imgt:Segment_378_1|rdf:type|imgt:Segment imgt:Construct_885|rdfs:label|Construct_885 imgt:Construct_1049|imgt:hasImgtLabel|imgt:scFv-lambda-heavy imgt:IgG4-kappa_496|imgt:hasConstruct|imgt:Construct_496 imgt:StudyProduct_4aa7a948-2d16-30f7-83bb-a19c45424e20|imgt:application_type|Therapeutic imgt:L-V-D-J-C-sequence|imgt:hasConfigurationType|imgt:R imgt:F9_(coagulation_factor_9_coagulation_factor_IX)-CTP_(C-terminal_peptide_of_the_β-subunit_of_human_chorionic_gonadotropin_(hCG))|rdfs:label|F9 (coagulation factor 9, coagulation factor IX) - CTP (C-terminal peptide of the β-subunit of human chorionic gonadotropin (hCG)) imgt:StudyProduct_463f9969-db5b-3005-89a0-f1b37bd38aeb|imgt:hasClinicalIndication|imgt:Cancer_hepatobiliary imgt:FN1-3|skos:definition|Fibronectin I imgt:IgG1-kappa_MM_269|imgt:hasConstruct|imgt:Construct_269 imgt:Cancers_colorectal_(CRC)_metastatic|imgt:isClinicalIndicationOf|imgt:StudyProduct_2ddd81e8-eba0-36ff-b70b-d8f066a71cc9 imgt:mAb_41|imgt:hasOriginClone|imgt:Clone_41 imgt:Construct_640|rdfs:label|Construct_640 imgt:mAb_864|imgt:hasProduct|imgt:Product_94d8dc7c-0c7e-33a1-a27f-260b76dbf359 imgt:mAb_427|imgt:hasImgtStructureEntry|imgt:9647 imgt:oxLDL|skos:definition|oxLDL (oxidized low-density lipoprotein (LDL), malondialdehyde (MDA)-modified apolipoprotein (apo) B-100) imgt:Product_dbe70051-84bf-318e-a2df-870d1dbb932a|imgt:hasStudyProduct|imgt:StudyProduct_cccb8781-4b8f-3c4b-96f1-dcb77db41d51 imgt:StudyProduct_e26eb2da-db55-3627-863a-e1eb92a9277d|imgt:hasDecision|_:Be2bd77e8edfae24486ea65d708111077 imgt:INSERM|rdf:type|obo:NCIT_C54131 _:Bd08f2014c17517fd730481c1487667f9|rdf:type|obo:NCIT_C53285 imgt:mAb_1217|rdf:type|obo:NCIT_C183320 imgt:Clone_1239|imgt:clone_name|2060B-B4Z2-03-C-T3-003 imgt:StudyProduct_b9072810-9533-3a19-98b8-01f007f2aeaa|rdfs:label|StudyProduct_b9072810-9533-3a19-98b8-01f007f2aeaa imgt:StudyProduct_984839c2-0995-31a4-91cc-8c5646058dca|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_c4a58d65-10f4-386e-8564-cadd29a4fb1f|rdfs:label|StudyProduct_c4a58d65-10f4-386e-8564-cadd29a4fb1f imgt:IgG2-kappa_467|obo:RO_0002162|imgt:Homsap imgt:StudyProduct_04b5780e-f239-3998-a7a4-33384d725488|rdf:type|obo:NCIT_C174271 imgt:RABV|rdf:type|obo:NCIT_C25702 imgt:Product_ed1b4d51-6349-3a0c-b888-039ed6131076|imgt:commun_name|Peg-IFNA2 K23 imgt:StudyProduct_14ef875e-bf47-3078-9f6e-3462f0e48969|imgt:hasDecision|_:Be09485c99ed6c8e237e3695b04c7ed7f imgt:IgG1-kappa_1123|http://semanticscience.org/resource/SIO_000291|imgt:CTLA4 imgt:Segment_487_2|imgt:segment_detail|Fc (Fragment constant) imgt:mAb_297|rdf:type|obo:NCIT_C61084 imgt:Segment_1208_1|imgt:has_rank|1 imgt:StudyProduct_aec72b5b-969b-3486-a11b-fe905a7ecdb7|rdf:type|obo:NCIT_C174271 imgt:Segment_1029_1|obo:BFO_0000050|imgt:Construct_1029 imgt:Optic_neuritis|imgt:isClinicalIndicationOf|imgt:StudyProduct_52308407-6e88-3b91-8ebe-dc1fc6809c57 imgt:Construct_188|imgt:isConstructOf|imgt:Fab-G4-nd_188 imgt:mAb_983|rdf:type|imgt:INN imgt:StudyProduct_29320b6a-0fab-3d74-aa2a-2e745b830dbd|imgt:hasExpressionSystem|imgt:_CHOK1SV_(expresses_glutamine_synthetase_(GS)_endogenously)_cells imgt:Product_971c8e9f-b2e9-3a2b-81cf-ec9cc91e320b|imgt:commun_name|REGN-910 imgt:mAb_297|imgt:hasProduct|imgt:Product_cf334a6e-5ae0-3dd4-8123-f5049b0a8300 imgt:Construct_131|rdfs:label|Construct_131 imgt:IgG4-kappa_358|imgt:isMabReceptorOf|imgt:mAb_358 imgt:StudyProduct_d09bb3d6-e5ad-3a18-a0be-17b78e4b532d|rdf:type|obo:NCIT_C174271 imgt:mAb_626|imgt:inn_number|5270 imgt:StudyProduct_0a8a5bf8-b179-3f11-aca7-644878e57936|rdfs:label|StudyProduct_0a8a5bf8-b179-3f11-aca7-644878e57936 imgt:Clone_96|obo:RO_0002162|imgt:Musmus imgt:StudyProduct_ef4916eb-5a12-3a93-b8b4-b692582617fc|imgt:hasClinicalIndication|imgt:Macular_edema_following_Retinal_Vein_Occlusion_(RVO) imgt:10344|imgt:isImgtStructureEntryOf|imgt:mAb_650 imgt:Segment_502_1|rdf:type|imgt:Segment imgt:StudyProduct_d38edf7d-aeb0-3e27-a95e-d4464805635c|imgt:isStudyProductOf|imgt:Product_0efba242-cde9-3874-a460-fdde00169ee1 imgt:scFv-kappa-heavy_536|http://semanticscience.org/resource/SIO_000291|imgt:VEGFA imgt:CytoDyn_Inc|rdfs:label|CytoDyn Inc. imgt:StudyProduct_fa63fa2f-f4fb-3169-9a7a-39ce5cdb63c7|rdfs:label|StudyProduct_fa63fa2f-f4fb-3169-9a7a-39ce5cdb63c7 imgt:Segment_371_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:mAb_789|imgt:inn_name|trastuzumab beta imgt:Fusion-Gamma1|rdfs:label|Fusion-Gamma1 imgt:Segment_959_1|obo:BFO_0000050|imgt:Construct_959 imgt:StudyProduct_225090d9-1146-3790-994d-0903145c5797|rdf:type|obo:NCIT_C174271 imgt:IgG1-kappa_340|rdfs:label|IgG1-kappa_340 imgt:StudyProduct_d2b50223-3fb8-3b6a-8411-ab91c7d308bd|rdfs:label|StudyProduct_d2b50223-3fb8-3b6a-8411-ab91c7d308bd imgt:mAb_55|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=55 imgt:Multiple_myeloma_(MM)|imgt:isClinicalIndicationOf|imgt:StudyProduct_ade418b9-459f-3107-afa0-2f9d48a0be61 imgt:Segment_1228_2|imgt:segment_detail|domain 3 fragment (206-308) imgt:StudyProduct_d571aff8-5be1-3eb0-9067-8bae72728f52|imgt:application_type|Therapeutic _:Bb1650d90e3379663c73b15c8fd192eff|imgt:isDecidedBy|imgt:FDA imgt:mAb_1162|imgt:inn_proposed_list|124 (2020) imgt:Segment_336_1|imgt:has_rank|1 imgt:StudyProduct_d13463ab-484e-3b47-821a-63605119d127|rdf:type|obo:NCIT_C174271 imgt:Clone_114|rdf:type|obo:NCIT_C37925 imgt:Product_c686f420-966d-3126-9f6f-930ef7238339|imgt:commun_name|NVP-LGT209 imgt:Construct_38|rdfs:label|Construct_38 imgt:FPIA_%5BPROTEIN_4REPEATS%5D2-FC_288|obo:RO_0002162|imgt:Homsap imgt:Product_bc514448-4d9c-3d80-8e18-14a8a87cb199|rdf:type|obo:NCIT_C51980 imgt:Product_1bf8b5fc-da79-3672-80d7-057ce5208e1d|imgt:isProductOf|imgt:mAb_429 imgt:mAb_813|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=813 imgt:StudyProduct_93ae5bed-fccf-3a69-8fb4-8157b4d16ae4|imgt:hasClinicalPhase|imgt:Preclinical imgt:PEPTIDE_706|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/PEPTIDE.png imgt:Clone_1093|rdf:type|obo:NCIT_C37925 pubmed:9265500|dc:title|Humanization of a mouse antibody against human alpha-4 integrin: a potential therapeutic for the treatment of multiple sclerosis. imgt:Construct_17|imgt:isConstructOf|imgt:IgG1-kappa_17 imgt:StudyProduct_57804234-9f3e-33cd-8224-70870f588db7|rdf:type|obo:NCIT_C174271 imgt:Product_efb61065-7b20-3c3c-a956-d520973c84fe|rdf:type|obo:NCIT_C51980 imgt:StudyProduct_79674173-710e-37b3-a168-683145b9f131|imgt:application_type|Therapeutic imgt:PDL_(Protein_Design_Labs)_BioPharma|imgt:produces|imgt:Product_2cb0cab5-75d3-3ff4-8cf5-4895a2fa5226 imgt:Segment_1158_4|imgt:segment_detail|Fc (Fragment constant) imgt:11390|imgt:isImgtStructureEntryOf|imgt:mAb_1068 imgt:Cancers_pancreatic|imgt:isClinicalIndicationOf|imgt:StudyProduct_7d774341-2500-3316-9259-6bbd4b727973 imgt:mAb_870|imgt:inn_proposed_list|119 (2018) imgt:Product_fc40a8ef-09f2-37c3-a3c1-798d05ff214e|rdfs:label|Product_fc40a8ef-09f2-37c3-a3c1-798d05ff214e imgt:StudyProduct_b8cb6d97-8a7b-3666-a4f8-691adcd82301|imgt:development_technology| ZMapp™ imgt:StudyProduct_95f2348f-0d7e-3304-99e9-a1649fc0abe7|rdfs:label|StudyProduct_95f2348f-0d7e-3304-99e9-a1649fc0abe7 imgt:mAb_1155|imgt:hasMabReceptor|imgt:IgG1-kappa-4cys-drug_1155 imgt:variable|rdf:type|imgt:GeneType imgt:StudyProduct_e027ab59-74de-3238-8f49-45275ebb305b|imgt:development_technology| POTELLIGENT® technology (afucosylation) imgt:mAb_372|imgt:hasMabReceptor|imgt:IgG1-kappa_372 imgt:mAb_318|rdf:type|obo:NCIT_C1909 imgt:Fusion-Fc-Gamma1|imgt:isDescribedBy|imgt:FUSION-FC-GAMMA-1 _:B853642d77454070f7f7e699eb59d9d5c|dc:date|2016-02-10 imgt:Segment_684_1|imgt:has_rank|1 imgt:StudyProduct_f1d4beb2-442f-3f2c-a3dd-b046eaca385a|imgt:hasDecision|_:B21bc7b18147a0be73eb29590a6ceee9d imgt:Segment_191_1|rdfs:label|Segment_191_1 imgt:StudyProduct_0e7b75a8-6262-35b4-ad60-0461975e3d3f|rdf:type|obo:NCIT_C174271 imgt:ENZ_1DOMAIN_782|rdf:type|imgt:MAbReceptor imgt:mAb_1225|imgt:inn_recommended_list|87 (2022) imgt:StudyProduct_af7ab420-55ff-3688-8469-664dcd2fd595|imgt:hasClinicalPhase|imgt:Discontinued imgt:Product_26793454-2d17-3d3e-a99a-1648d65e5dd2|imgt:hasStudyProduct|imgt:StudyProduct_3455d67d-e5f8-3178-96e4-d1ae4163795e imgt:%5BV-kappa%5D2-Fc_429|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/[V-kappa]2-Fc.png imgt:MAbReceptor_117|imgt:hasMolecularComponent|imgt:IG imgt:Construct_88|rdfs:label|Construct_88 imgt:StudyProduct_53183842-71ef-3bbc-a045-3c4e63aa385f|imgt:isStudyProductOf|imgt:Product_c299e202-690b-3ffc-8c53-e45056548ad0 imgt:Product_ccaee58d-d4c1-3c86-90f0-df9bb7bf2ae1|imgt:hasStudyProduct|imgt:StudyProduct_3285d699-b694-3b33-b63d-0692bc62e613 imgt:mAb_1045|imgt:inn_proposed_list|122 (2019) imgt:Product_981dc5f1-b82e-3839-b7ef-ffb6e029ad46|imgt:commun_name|DS-1062a imgt:%5BPEPTIDE-PEPTIDE%5D2-FC_413|rdfs:label|[PEPTIDE-PEPTIDE]2-FC_413 imgt:StudyProduct_8fbe27b0-9f2d-3db9-9003-bb0408a6f289|rdf:type|obo:NCIT_C174271 imgt:Product_3a189900-85ec-39fd-961e-db4cc48bbcb2|rdfs:label|Product_3a189900-85ec-39fd-961e-db4cc48bbcb2 imgt:TR-Gamma-4-TRGC4|imgt:hasChainTypeLevel|imgt:TR-Gamma-TRG imgt:IgG4-kappa_529|rdf:type|imgt:MAbReceptor imgt:PEP_(1-7)|rdfs:label|PEP (1-7) imgt:IgG1-lambda_1089|imgt:isMabReceptorOf|imgt:mAb_1089 imgt:Clone_269|imgt:clone_name|HMFG-1 pubmed:16699037|dc:contributor|Murakami T imgt:ConfigurationType|owl:disjointWith|imgt:FunctionalityType imgt:StudyProduct_8fb6a13c-fe54-3f1d-93d6-d8eb4c7f93b7|rdf:type|obo:NCIT_C174271 imgt:Product_276309a1-1c55-3b9c-a3bc-658a7d618861|imgt:isProducedBy|imgt:Bristol-Myers_Squibb imgt:Product_e521e71e-0d27-3157-a807-f8780c379245|imgt:hasStudyProduct|imgt:StudyProduct_a9f55676-d321-39a7-8686-9ee4acfc0ef9 imgt:(scFv-heavy-lambda)-(scFv-heavy-lambda)-scFc|rdfs:label|(scFv - heavy - lambda) - (scFv - heavy - lambda) - scFc imgt:PROTEIN_1DOMAIN_893|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/PROTEIN_1DOMAIN.png imgt:IgG1-kappa-4cys-drug3_1134|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa-4cys-drug3.png imgt:Innovent_Biologics|imgt:produces|imgt:Product_4384026e-ba8b-350f-b05f-d196a99c173c imgt:Rheumatoid_arthritis_(RA)|imgt:isClinicalIndicationOf|imgt:StudyProduct_1204991a-cd46-3f61-85bb-d54a4922eb42 imgt:V-D-(DJ)-C-CLUSTER|skos:definition|genomic DNA of an IG or TR locus, in rearranged configuration, including at least one V-GENE, one D-GENE, one D-J-GENE and one C-GENE imgt:ImClone_Systems_Inc|imgt:produces|imgt:Product_50c728d9-1b75-34fb-a648-dd8d841f3a78 imgt:StudyProduct_ea0afbf7-0368-37d0-9d22-e22c3668a661|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:mAb_206|rdfs:label|mAb_206 imgt:Cancers_colorectal_(CRC)_metastatic|imgt:isClinicalIndicationOf|imgt:StudyProduct_350c082b-83b8-3353-9d33-abfc733b1d61 imgt:PDCD1|imgt:isTargetOf|imgt:IgG4-kappa_863 imgt:StudyProduct_30ca685c-4a56-38dc-83e8-a4cd1446d583|imgt:hasClinicalIndication|imgt:Non-alcoholic_steatohepatitis_(NASH) imgt:StudyProduct_1884c1fa-e53a-3bd2-b507-eae4c4c1906e|rdfs:label|StudyProduct_1884c1fa-e53a-3bd2-b507-eae4c4c1906e imgt:Construct_756|imgt:isConstructOf|imgt:IgG1-kappa_756 imgt:IgG1-kappa-2cys-CH3_879|obo:RO_0002162|imgt:Chi imgt:StudyProduct_fdbfed3e-6d3c-31a1-ab0c-e84a3891fa36|imgt:development_technology| Abgenix's XenoMouse® imgt:Musmus_CD3E|obo:RO_0002162|imgt:Musmus imgt:StudyProduct_0485cef8-ac82-346b-aa36-ae9f4bdb7da9|rdf:type|obo:NCIT_C174271 imgt:Product_db3d4ac6-821a-3423-ba1d-61b8ad6cf363|rdf:type|obo:NCIT_C51980 imgt:CD40LG|obo:RO_0002162|imgt:Homsap imgt:mAb_238|imgt:inn_recommended_list|65 (2011) imgt:C-GAMMA-7|skos:definition|C-DOMAIN of a TR-GAMMA-7 chain imgt:Cancers|imgt:isClinicalIndicationOf|imgt:StudyProduct_01e5893e-0e67-39fa-93d1-fa55aab75633 imgt:StudyProduct_93dd0dc0-9322-3b0b-b887-8fbf2be423cd|rdf:type|obo:NCIT_C174271 imgt:mAb_249|imgt:inn_proposed_list|94 (2005) imgt:Product_4384026e-ba8b-350f-b05f-d196a99c173c|imgt:hasStudyProduct|imgt:StudyProduct_710bd5bc-4aa1-3826-b517-c43b813897cf imgt:StudyProduct_5ba733d3-a9b0-3fca-b17c-8f2433a04435|imgt:hasClinicalPhase|imgt:Phase_III imgt:IgG4-kappa_807|rdfs:comment|IgG4 - kappa imgt:StudyProduct_992fc642-4f83-377b-9e80-da41e1824def|imgt:hasClinicalPhase|imgt:Phase_M imgt:mAb_560|rdfs:label|mAb_560 imgt:Lymphoma_B_cell|imgt:isClinicalIndicationOf|imgt:StudyProduct_3ca3e910-358e-307b-a4aa-fa5f618d3333 _:B20b13201cf0b01499db0bf981d116d44|imgt:hasStatut|imgt:approval imgt:mAb_799|rdfs:label|mAb_799 imgt:Product_60d91c1d-7e8c-312e-9396-a6b81431577f|imgt:hasStudyProduct|imgt:StudyProduct_0f0dd0bb-f4b9-34f4-acf1-c931e5292c31 imgt:StudyProduct_4fdcd687-2c1c-3c05-9943-0108644d68a2|rdf:type|obo:NCIT_C174271 imgt:Product_548e85bb-73f0-3eda-a78b-8134d0e04416|imgt:commun_name|polatuzumab vedotin-piiq imgt:StudyProduct_43c6a240-a4d7-3834-a62e-3bff5e8b3114|imgt:hasClinicalPhase|imgt:Phase_II imgt:Segment_53_1|obo:BFO_0000050|imgt:Construct_53 imgt:Product_e29ca1a6-d717-32be-8922-7f11c322da77|rdfs:label|Product_e29ca1a6-d717-32be-8922-7f11c322da77 imgt:StudyProduct_2b14bfff-9798-340b-b834-432071918ab6|rdfs:label|StudyProduct_2b14bfff-9798-340b-b834-432071918ab6 imgt:Product_c7e70c82-a2f1-32d7-9982-829cd1d4d4e7|imgt:commun_name|ch14.18/CHO imgt:Product_5395e1f9-f530-3052-8132-b2d17de5d5f8|imgt:commun_name|ECF-843 imgt:L-AA-chain|protege:protege#subclassesDisjoint|true imgt:StudyProduct_c1f5df6a-fb42-33e0-bc04-a30586e3f522|imgt:hasClinicalIndication|imgt:Lymphoma_diffuse_large_B_cell_(DLBCL) imgt:VH-V-KAPPA-CH2-CH3|rdf:type|imgt:ChainLabels imgt:StudyProduct_18202ff2-6df9-3d9a-8f0d-e4c7b4ac3a88|imgt:hasClinicalIndication|imgt:Non-alcoholic_steatohepatitis_(NASH) imgt:mAb_301|imgt:hasProduct|imgt:Product_3d70c6f7-d58f-3dbd-b8a0-06517209c35b imgt:StudyProduct_fb04dcf4-fa40-31d0-b04d-bb8c0ffd8ade|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_cells imgt:Product_8a0ac4eb-a8dd-3147-bc12-a4ce3c797eac|imgt:commun_name|KN026 imgt:Segment_904_1|imgt:has_rank|1 imgt:11240|imgt:isImgtStructureEntryOf|imgt:mAb_1056 imgt:isPrototypeOf|owl:inverseOf|imgt:isInPrototype imgt:Product_90f4823e-5cb9-333f-bd91-f83046626483|imgt:commun_name|AMG-181 imgt:Product_e5ca6245-7a11-3390-b7de-6b5e8870b2ab|imgt:commun_name|pSVIE26 imgt:mAb_1149|imgt:hasProduct|imgt:Product_90e04c5a-577a-3800-b896-3874f1195f39 imgt:mAb_225|imgt:imgt_note| Vaxira® is a therapeutic vaccine for the treatment of non-small cell lung cancer (NSCLC). It is composed of Racotumomab and aluminum hydroxide adjuvant. Racotumomab is an anti-idiotypic mouse monoclonal antibody that mimics N-glycolil (NGc) gangliosides, thus triggering an immune response against the tumor antigen N-glycolil (NGc) GM3 (NGcGM3). imgt:IG-Light-Iota-3-IGI3|rdf:type|imgt:ChainType imgt:Construct_182|rdfs:label|Construct_182 imgt:Construct_463|obo:BFO_0000051|imgt:Segment_463_1 imgt:IgG1-kappa_354|imgt:isMabReceptorOf|imgt:mAb_354 imgt:mAb_985|rdf:type|obo:NCIT_C174683 imgt:Segment_71_1|rdf:type|imgt:Segment imgt:mAb_116|imgt:hasOriginClone|imgt:Clone_116 imgt:Product_5e6fb815-05e1-389d-909a-e10ff1c0fa2c|imgt:commun_name|Y-90 Zevalin imgt:StudyProduct_6fa2687b-6915-3b16-86ac-2b3309cc6cbc|imgt:hasDecision|_:Befd608342a1d726258a4e05030a5955e _:B8611164b7e4e98463264a4bc1c00e297|dc:date|2020-02-06 imgt:Graft-versus-host_disease_(GvHD)|imgt:isClinicalIndicationOf|imgt:StudyProduct_d61cdbc7-d49b-3c3c-8db0-e0f053e8957e imgt:StudyProduct_81958a90-90dc-3b31-822e-012da3e7ff76|imgt:application_type|Therapeutic imgt:Product_e486c14a-a89f-327e-8f36-b95267609593|rdf:type|obo:NCIT_C51980 imgt:Groupe_Suisse_de_Recherche_Clinique_(SAKK)|rdfs:label|Groupe Suisse de Recherche Clinique (SAKK) imgt:Segment_696_1|imgt:hasImgtLabel|imgt:Follicle-stimulating_hormone_(FSH) imgt:mAb_1134|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=1134 imgt:Segment_354_1|rdfs:label|Segment_354_1 imgt:Segment_534_1|obo:BFO_0000050|imgt:Construct_534 imgt:IgG1-kappa_MM_286|imgt:hasConstruct|imgt:Construct_286 imgt:PROTEIN_1DOMAIN_893|imgt:hasConstruct|imgt:Construct_893 imgt:conventional|skos:definition|Identifies any (coding or not coding) gene other than IG or TR genes with or withour a leader L region (or signal peptide). imgt:Segment_1193_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:mAb_767|imgt:inn_recommended_list|79 (2018) imgt:Psoriasis|imgt:isClinicalIndicationOf|imgt:StudyProduct_e0972da3-858b-31a1-a325-0ad05e8228fe imgt:Janssen_Pharmaceuticals_inc|imgt:produces|imgt:Product_a0ec6f87-28fe-3db8-b9ac-2a212fe42735 imgt:IgG4-kappa_916|rdfs:comment|IgG4 - kappa imgt:mAb_382|rdfs:label|mAb_382 imgt:IgG1-kappa-%5BscFv%5D2-kappa_1196|imgt:isMabReceptorOf|imgt:mAb_1196 imgt:mAb_1283|imgt:hasProduct|imgt:Product_a8e7144e-8be0-3481-a89b-994c08a8e5d0 imgt:IgG2a-kappa-G2b-lambda_219|imgt:hasMolecularComponent|imgt:IG imgt:Segment_1082_1|rdf:type|imgt:Segment imgt:Product_cb1dc7ce-b8b2-385d-93aa-ad7f2c2311af|rdf:type|obo:NCIT_C51980 imgt:Product_7a590139-a8dc-33f6-b868-ffaa80fc628a|rdfs:label|Product_7a590139-a8dc-33f6-b868-ffaa80fc628a imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_dbf9c186-16b6-3efe-bf6e-d1dc4dd0f50c imgt:mAb_663|imgt:inn_recommended_list|77 (2017) imgt:VH-C-kappa-CH2-CH3_V-lambda-CH1_H-GAMMA-1_L-kappa_793|http://semanticscience.org/resource/SIO_000291|imgt:ANGPT2 imgt:ERBB2|imgt:isTargetOf|imgt:MAbReceptor_99 imgt:IgG1-kappa-4cys-drug_896|imgt:conjugated_with| monomethyl auristatin E (MMAE) imgt:StudyProduct_0d159da4-02de-3768-90bb-c071c26d5c1a|imgt:hasClinicalIndication|imgt:Chronic_lymphocytic_leukemia_(CLL) imgt:Product_971c8e9f-b2e9-3a2b-81cf-ec9cc91e320b|imgt:isProductOf|imgt:mAb_452 imgt:Product_25709140-bbc7-373c-9a44-2be9be3d8e9d|imgt:hasStudyProduct|imgt:StudyProduct_c286e60e-41e0-36d5-b2cb-d414b008e43d imgt:mAb_979|imgt:inn_number|11143 imgt:StudyProduct_f10b69b4-9b96-3b12-90bd-f4ad4207ce07|rdfs:label|StudyProduct_f10b69b4-9b96-3b12-90bd-f4ad4207ce07 imgt:Product_866ef94f-ee49-3c14-abc0-90cbc78d1192|imgt:commun_name|BAY2010112 imgt:HOR-CTP_1051|imgt:hasMolecularComponent|imgt:CPCA imgt:Product_527cd5df-73d5-3032-9885-15b54f61e5ba|imgt:commun_name|CT-P22 imgt:Construct_154|imgt:hasImgtLabel|imgt:IgG1-lambda imgt:Product_7a590139-a8dc-33f6-b868-ffaa80fc628a|imgt:hasStudyProduct|imgt:StudyProduct_beb58537-8503-3cb1-a6b2-0deccc1df0f7 imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_5b97ae15-7bde-3a7a-9fe1-06cc7f6abc5b imgt:Product_01c1772e-8943-3b54-b0fe-518a65f83c6d|imgt:isProducedBy|imgt:Regeneron_Pharmaceuticals_Inc imgt:Cancers_pancreatic|imgt:isClinicalIndicationOf|imgt:StudyProduct_8405743a-9a21-385b-a81a-5dba154058ef imgt:Segment_1283_1|rdf:type|imgt:Segment imgt:Construct_809|obo:BFO_0000051|imgt:Segment_809_1 imgt:_CHO_(Chinese_Hamster_Ovary)_cells|imgt:isExpressionSystemOf|imgt:StudyProduct_6cb83d68-2322-30f7-abde-324ed037e7b0 imgt:IgG1-kappa_296|rdfs:comment|IgG1 - kappa imgt:StudyProduct_29562df2-37fe-38ae-a623-e694518eba7f|imgt:hasExpressionSystem|imgt:_CHO_(Chinese_Hamster_Ovary)_MTX_(methotrexate_resistant)_cells imgt:HGF|skos:definition|HGF (hepatocyte growth factor, scatter factor, SF, hepatopoeitin A) imgt:GDF11|obo:RO_0002162|imgt:Homsap imgt:Product_97551870-12ac-39cb-a566-96ca9d85ebc5|imgt:commun_name|AMG994 imgt:StudyProduct_9cd41eec-27b9-3ac7-969a-fe29e7e4d50a|imgt:application_type|Therapeutic imgt:Refractory_unstable_angina_when_percutaneous_coronary_intervention_is_planned|imgt:isClinicalIndicationOf|imgt:StudyProduct_e18346b4-c502-3a24-9514-3f9ecb2d5d74 _:B9f75d5a9722b8d37103fafd272a7e109|dc:date|2017-05-22 imgt:mAb_480|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=480 imgt:StudyProduct_271d9873-81bc-3539-8d98-3e0e1868fdb9|imgt:hasClinicalIndication|imgt:Cancers_prostate imgt:Septic_shock_MSS_(meningococcal_septic_shock)|imgt:clinical_domain|Infectiology imgt:IgG2a-kappa_132|obo:RO_0002162|imgt:Musmus imgt:PROTEIN_1DOMAIN-PEG_741|imgt:isMabReceptorOf|imgt:mAb_741 imgt:Segment_270_1|imgt:has_rank|1 imgt:9333|imgt:isImgtStructureEntryOf|imgt:mAb_353 imgt:mAb_268|imgt:hasProduct|imgt:Product_8f121ce0-7d74-317e-8b1f-21d122e04521 imgt:mAb_262|imgt:inn_number|8536 imgt:IgG4-kappa_922|imgt:hasConstruct|imgt:Construct_922 imgt:StudyProduct_7096f391-b9a4-3c65-82a3-94251af99833|imgt:isStudyProductOf|imgt:Product_35c6ca74-2743-3354-8965-d8ba06e48503 imgt:mAb_389|imgt:hasImgtStructureEntry|imgt:9486 imgt:IgG1-kappa_677|imgt:isMabReceptorOf|imgt:mAb_677 imgt:Product_88568e72-96c0-305a-a89f-24f789162533|imgt:isProducedBy|imgt:Kaketsuken_(the_Chemo-Sero-Therapeutic_Research_Institute) imgt:Product_5a522bda-223b-3b4e-80fb-796b1b9ea3b5|imgt:isProductOf|imgt:mAb_259 imgt:Palatin_Technologies_Inc|imgt:produces|imgt:Product_e71972eb-fe86-3835-944b-ec9b77978c50 imgt:mAb_64|imgt:inn_proposed_list|104 (2010) imgt:IgG4-kappa_1001|rdfs:comment|IgG4 - kappa imgt:Segment_578_1|imgt:hasImgtLabel|imgt:IgG4-kappa imgt:IgG1-kappa_771|rdfs:comment|IgG1 - kappa imgt:mAb_957|rdf:type|obo:NCIT_C142077 imgt:partially_rearranged|skos:definition|Identifies, whatever the molecule type, the configuration of partially_rearranged IG or TR diversity (D) genes, and by extension, the configuration of Molecule_EntityType leafconcepts that contain at least one partially_rearranged D gene [with another D or with rearranged variable (V) or joining (J) genes (with or without constant (C) genes in undefined configuration)]. imgt:FCGRT|imgt:isTargetOf|imgt:IgG1-lambda_943 imgt:PTPRC|rdfs:label|PTPRC imgt:Product_442a60e9-44f1-3d58-be60-70178de04384|imgt:commun_name|AK-101 imgt:Anemia|imgt:isClinicalIndicationOf|imgt:StudyProduct_be0d2ceb-d851-3086-a0d2-f71778e37c76 imgt:9798|rdf:type|obo:NCIT_C25402 imgt:StudyProduct_33e211b6-ebe4-3a0c-b988-d774ed17c900|rdf:type|obo:NCIT_C174271 imgt:Product_b4f695a5-b31d-356e-91fe-c87b71b14b4d|rdf:type|obo:NCIT_C51980 imgt:Segment_954_1|rdfs:label|Segment_954_1 imgt:StudyProduct_9f190a40-7b10-3eba-9bc2-9c3ad668abf1|rdfs:label|StudyProduct_9f190a40-7b10-3eba-9bc2-9c3ad668abf1 imgt:Construct_756|rdf:type|imgt:Construct imgt:TR-ALPHA_BETA-2|rdf:type|imgt:StructureLabels imgt:Product_12bb60ec-d709-3f8e-b1fa-e45ee68fca8d|imgt:commun_name|HSA-rG-CSF imgt:TNF|skos:definition|TNF (tumor necrosis 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imgt:Product_7a3ec779-a1bd-30e8-a7a2-4a6524b06459|imgt:hasStudyProduct|imgt:StudyProduct_de320008-8c62-3306-9a78-58ca680e0124 imgt:Product_3fc6bf12-9b61-329f-b867-eef0c9cd3e83|imgt:commun_name|interferon beta-1a imgt:mAb_1146|imgt:hasProduct|imgt:Product_c7359b30-f05b-3766-9171-fb55d36b7b20 imgt:EntityType|owl:disjointWith|imgt:MoleculeUnit imgt:Debiopharm_Internaltional_SA|imgt:produces|imgt:Product_6c744b68-d951-35cb-a171-f909e1c18d90 imgt:Product_ebb4f69a-d3ff-36d7-9ec4-113a4f08e885|imgt:commun_name|HuM195 imgt:Product_27b2ce59-fbe0-3c24-abf6-bf39a8d6c18b|imgt:commun_name|AS1409 imgt:mAb_558|imgt:hasImgtStructureEntry|imgt:10096 imgt:StudyProduct_66442d8f-2ea8-3e4e-b7bb-e1dd8b235ba0|imgt:hasClinicalPhase|imgt:Phase_II/III imgt:IgG1-kappa_1062|http://semanticscience.org/resource/SIO_000291|imgt:SLC1A5 imgt:PROTEIN_1DOMAIN_778|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/PROTEIN_1DOMAIN.png 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imgt:mAb_142|imgt:inn_number|7827 imgt:Product_9988ec5b-fd7a-325e-bd3f-39829a8fc36d|imgt:hasStudyProduct|imgt:StudyProduct_f0f33bd5-8f18-36e2-97c2-5f7c94332ea9 imgt:11574|imgt:isImgtStructureEntryOf|imgt:mAb_1161 imgt:clinical_trials|rdf:type|owl:AnnotationProperty imgt:mAb_1115|imgt:inn_number|11119 imgt:StudyProduct_fdff8784-b695-34d2-a25e-b4c872047a37|imgt:hasClinicalPhase|imgt:Phase_III imgt:Segment_680_1|rdfs:label|Segment_680_1 imgt:IL6|rdf:type|obo:NCIT_C25702 imgt:Construct_636|rdf:type|imgt:Construct imgt:StudyProduct_68b8e20f-19b6-3ffe-8513-7bdc40b8156b|imgt:hasClinicalIndication|imgt:Multiple_sclerosis_(MS) imgt:mAb_1057|imgt:hasMabReceptor|imgt:(scFv-heavy-kappa)-(scFv-heavy-lambda)_1057 imgt:IgG4-kappa_898|rdfs:label|IgG4-kappa_898 imgt:Product_b9a738f9-5b22-38f9-848f-e3ea2ee2b97d|rdf:type|obo:NCIT_C51980 imgt:mAb_360|imgt:inn_recommended_list|66 (2011) imgt:V-D-J-C-REGION|skos:definition|coding region of an IG or TR that comprises V-REGION, any D-REGION and N-REGION, J-REGION and C-REGION, in rearranged spliced cDNA or artificially spliced gDNA imgt:Product_8f2b525d-90b5-3eb3-92db-11b02305df48|imgt:isProductOf|imgt:mAb_167 imgt:mAb_294|imgt:imgt_note| ImClone Systems became a wholly-owned subsidiary of Eli Lilly and Company on November 24, 2008. Press release imgt:SELP|skos:definition|SELP (selectin P, CD62) _:B31c3ef8b80f16faeccb1b48aab205dcc|dc:date|2016-04-25 imgt:Construct_906|imgt:isConstructOf|imgt:F(ab%27)2-G1-kappa-PROT_906 _:B9a18df280693864fda74cf3c7f16a3ac|imgt:hasDesignation|imgt:Orphan_drug imgt:Product_269943d5-585d-3935-924a-367a035801fc|imgt:commun_name|BMS-986015 imgt:mAb_858|imgt:inn_number|10874 imgt:Clone_158|rdfs:label|Clone_158 imgt:Product_8232fb63-0976-3003-9d0b-804e47a16825|imgt:hasStudyProduct|imgt:StudyProduct_cf211e0b-6a75-3b78-919e-27956a3554aa imgt:IgG1-nd_443|obo:RO_0002162|imgt:Homsap imgt:IgG1-lambda_650|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-lambda.png imgt:Product_ee42c2a8-bd22-307b-8b06-6b191270e9a0|imgt:commun_name|clone 9TL imgt:Product_c0796800-04f9-3ea1-9bd6-c35217a2ca33|rdfs:label|Product_c0796800-04f9-3ea1-9bd6-c35217a2ca33 imgt:mAb_834|imgt:inn_proposed_list|119 (2018) imgt:StudyProduct_838b5be0-7266-3d65-bedc-26272c95fa9b|rdf:type|obo:NCIT_C174271 imgt:Construct_215|rdf:type|imgt:Construct imgt:StudyProduct_a2ab455f-b27b-31b9-ba4d-cd7a294464dc|imgt:hasDecision|_:B95068bd09ddc78a421d56b78e5fc9385 imgt:Product_4d3e419a-89b3-3235-9f0f-4e098837e002|imgt:isProductOf|imgt:mAb_141 imgt:Construct_242|imgt:hasImgtLabel|imgt:Fab%27-G1-kappa imgt:mAb_894|rdf:type|imgt:INN imgt:Adult-onset_Still’s_disease_(AOSD)|imgt:clinical_domain|Immunology imgt:StudyProduct_999c3e3c-f67a-3f68-8491-44ef9f001b19|imgt:hasClinicalPhase|imgt:Phase_II imgt:IgG1-kappa-%5BPROTEIN%5D2_914|rdfs:comment|IgG1-kappa-[PROTEIN]2 imgt:StudyProduct_04c83926-e60f-30cc-b3fc-12387e2a27cb|imgt:application_type|Therapeutic obo:NCIT_C100101|rdf:type|owl:Class imgt:Product_c9cafb67-7c5b-36ee-93fb-4c7df9648b85|imgt:comercial_name|PROTOVIR™ imgt:GH1_(growth_hormone_1_somatotropin_GH_GH-N_GHN_hGH-N_pituitary_growth_hormone)|imgt:construction_detail|GH1 (growth hormone 1, somatotropin, GH, GH-N, GHN, hGH-N, pituitary growth hormone) imgt:StudyProduct_4a815db4-c662-3d9e-a584-51db01c7a9fa|imgt:hasClinicalIndication|imgt:Cancers_colorectal_(CRC) imgt:StudyProduct_ea32661f-d823-3db2-a1de-f9a6e627ebd0|imgt:application_type|Therapeutic imgt:G-ALPHA2-LIKE|rdf:type|imgt:ChainLabels imgt:Segment_587_1|imgt:has_rank|1 imgt:mAb_853|imgt:inn_proposed_list|119 (2018) imgt:StudyProduct_22eab2bd-fcca-323d-b4ba-b74c6bac47a7|imgt:application_type|Therapeutic imgt:mAb_457|rdf:type|imgt:INN imgt:StudyProduct_b03c0e61-e11c-3a86-bf82-dbd54cd8549c|imgt:isStudyProductOf|imgt:Product_08b4009b-8932-3d41-9240-3bfa3c889ea0 _:Bfbd72133cbc3df9460c7bc530e2451c7|rdf:type|obo:NCIT_C53285 imgt:StudyProduct_7e9612a2-9c03-375f-9baa-d119aa6ee68c|imgt:isStudyProductOf|imgt:Product_abdc580d-8408-3e32-b850-2b01e4fac11e imgt:StudyProduct_567dca9c-f362-30db-b121-50386b4dbb4b|imgt:isStudyProductOf|imgt:Product_cf2f7fdd-756d-34db-a0a8-796cf3a5e368 _:Be2a6c2341f225bd603e308a14f8df42d|imgt:hasDesignation|imgt:Orphan_drug imgt:Regeneron_Pharmaceuticals_Inc|imgt:produces|imgt:Product_dbe05b64-0640-322a-811c-7c37fcafe09b imgt:THPO|rdf:type|imgt:SegmentLabels imgt:KIR3DL2|rdf:type|obo:NCIT_C25702 imgt:Product_da115066-6a6b-3fbc-83fe-48573602f57d|imgt:hasStudyProduct|imgt:StudyProduct_4388234b-49e5-3577-9d2d-284e40ef17be imgt:PDCD1|imgt:isTargetOf|imgt:G1-kappa_scFv-h-CH2-CH3_1085 imgt:Product_d83f11d1-0413-38d7-9027-724429ec0e9f|imgt:commun_name|LAPS-hGH imgt:mAb_500|rdf:type|imgt:INN imgt:Segment_836_1|rdf:type|imgt:Segment imgt:Construct_352|rdfs:label|Construct_352 imgt:Product_a7a3a8e3-962a-3cab-8c20-baf4baa0f755|rdf:type|obo:NCIT_C51980 imgt:Product_5a522bda-223b-3b4e-80fb-796b1b9ea3b5|imgt:comercial_name|BESPONSA® imgt:Product_b7bee7b5-34bb-3282-9b4f-2678b12b5b39|imgt:comercial_name|ONCOLTAD® pubmed:11373411|dc:contributor|Abraham E imgt:Segment_896_1|rdfs:label|Segment_896_1 imgt:StudyProduct_f8da3f77-3733-32fd-b4fc-d5ef2bae5cfb|imgt:development_technology| Dual-Affinity Re-targenting (DART®) imgt:IgG4-kappa_649|rdfs:comment|IgG4 - kappa imgt:mAb_983|imgt:inn_recommended_list|83 (2020) imgt:mAb_268|imgt:hasMabReceptor|imgt:IgG1-nd_MM_268 imgt:Segment_334_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:tetravalent|skos:definition|tetravalent imgt:Segment_1126_1|rdf:type|imgt:Segment imgt:Segment_742_1|imgt:has_rank|1 imgt:Johnson_&_Johnson|imgt:produces|imgt:Product_eb6a1c8e-f445-3794-a73f-0451f26bb760 imgt:StudyProduct_c6494b0e-d421-3873-97b8-dfb8dcff49a7|imgt:hasClinicalIndication|imgt:Multiple_myeloma_(MM) imgt:mAb_658|imgt:hasMabReceptor|imgt:IgG1-kappa_658 imgt:mAb_814|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=814 imgt:mAb_395|imgt:inn_name|asfotase alfa imgt:Construct_184|imgt:hasImgtLabel|imgt:IgG1-nd imgt:mAb_184|imgt:hasProduct|imgt:Product_e9725593-72db-3005-b841-06e3fc3b71a1 imgt:IG-Heavy-Epsilon-IGHE|imgt:defines|imgt:IgE_Kappa imgt:Cancers_non-small_cell_lung_(NSCLC)|imgt:isClinicalIndicationOf|imgt:StudyProduct_d5c38a4f-d234-351d-b8f6-c63225acb3a4 imgt:mAb_511|rdfs:label|mAb_511 imgt:Product_e25f50c3-9b20-361d-9c46-198fe111366e|imgt:hasStudyProduct|imgt:StudyProduct_2a973a1a-e37f-35eb-9dc5-08529b842cc7 imgt:Segment_373_1|imgt:has_rank|1 imgt:StudyProduct_88ac1799-ed28-3ed0-ba98-64ed71a84b83|imgt:hasClinicalPhase|imgt:Phase_III imgt:Product_2e0c3e19-bb60-39f0-a8bb-1895ab10b1d7|imgt:isProducedBy|imgt:Adaptimmune_LLC imgt:mAb_241|imgt:hasMabReceptor|imgt:IgG4-kappa_241 imgt:Product_07fcf0c6-e4a8-3c64-afb5-82113a3165b0|imgt:hasStudyProduct|imgt:StudyProduct_e8b0cc56-aea9-3ccc-bbb1-8e9b24c3570f imgt:StudyProduct_97e07b84-1b9e-3c7e-b342-212c4831a15c|imgt:application_type|Therapeutic imgt:Construct_1296|rdf:type|imgt:Construct imgt:HOR-CTP_697|imgt:fused_with| CTP (C-terminal peptide of hCG) imgt:mAb_260|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=260 _:Ba0efc371b21218ffe9ccca88240bbfcc|imgt:hasStatut|imgt:approval imgt:10803|rdf:type|obo:NCIT_C25402 obo:NCIT_C25402|rdfs:subClassOf|imgt:SEQUENCE imgt:mAb_664|imgt:imgt_note| 2012 - the compound was licensed to AstraZeneca by Amgen for global joint development and commercialization. In 2007, AstraZeneca bought MedImmune created in 1988. On Feb 14, 2019, it was announced that MedImmune will cease to exist as an industry name as the owner AstraZenaca has decided to retire the brand as part of ongoing restructuring efforts.https://www.biopharmadive.com/news/astrazeneca-retires-medimmune-name-amid-sales-turnaround/548489/ imgt:StudyProduct_87de7170-5b33-3250-be77-1d6446431494|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_b8f60edc-9e59-388c-aaab-4c5b45bb9106|imgt:application_type|Therapeutic imgt:Construct_855|rdfs:label|Construct_855 imgt:mAb_1167|imgt:hasOriginClone|imgt:Clone_1167 imgt:Construct_782|rdfs:label|Construct_782 imgt:Segment_779_1|rdfs:label|Segment_779_1 imgt:Product_fe96a2d6-ec45-32a9-ad98-947492fcd282|rdfs:label|Product_fe96a2d6-ec45-32a9-ad98-947492fcd282 imgt:IgG1-kappa-4cys-drug_324|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG1-kappa-4cys-drug.png obo:NCIT_C171840|rdf:type|owl:Class imgt:Product_5f30147d-a531-39c4-9e76-b508ed704e09|rdf:type|obo:NCIT_C51980 imgt:IgG4-kappa_1131|rdfs:comment|IgG4 - kappa imgt:Segment_172_1|imgt:has_rank|1 imgt:mAb_202|imgt:hasMabReceptor|imgt:MAbReceptor_202 imgt:Product_05e5be80-e208-3f76-b968-e0554e88cdc8|imgt:commun_name|CNTO 136 imgt:Clone_356|rdfs:label|Clone_356 imgt:mAb_973|imgt:inn_recommended_list|83 (2020) imgt:Product_ed79f4b0-7ee9-336f-9b80-2a7c225d9ac4|imgt:isProducedBy|imgt:ASLAN_Pharmaceuticals imgt:Factor_VII_deficiency_(treatment_of_bleeding_episodes)|rdfs:label|Factor_VII_deficiency_(treatment_of_bleeding_episodes) imgt:Product_4f94741f-29e5-3159-8942-1c87a52ed26e|rdfs:label|Product_4f94741f-29e5-3159-8942-1c87a52ed26e imgt:Construct_106|rdfs:label|Construct_106 imgt:Construct_852|imgt:isConstructOf|imgt:IgG1-lambda_852 imgt:StudyProduct_2394b2ec-3d78-30aa-a147-6fca07f60040|imgt:hasClinicalIndication|imgt:Rheumatoid_arthritis_(RA) imgt:mAb_719|imgt:hasMabReceptor|imgt:IgG1-kappa_719 imgt:mAb_175|imgt:hasOriginClone|imgt:Clone_175 imgt:StudyProduct_f293da32-20d7-3f78-aa0c-d0d12e5145e8|imgt:isStudyProductOf|imgt:Product_a5c1a1b9-506a-361d-a62c-eee6f10d449a imgt:mAb_773|imgt:inn_name|ladiratuzumab vedotin imgt:Acute_lymphocytic_leukemia_(ALL)|imgt:isClinicalIndicationOf|imgt:StudyProduct_f7ad8347-265c-3167-afae-3618b62d9db2 imgt:StudyProduct_c1f5df6a-fb42-33e0-bc04-a30586e3f522|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_d8975ef7-2490-31f4-bc09-19a2451ae706|imgt:application_type|Therapeutic obo:NCIT_C71531|rdfs:subClassOf|obo:NCIT_C1909 imgt:Product_cbd0baaf-87ab-3efd-87a0-619e0f9667a5|imgt:isProducedBy|imgt:CSL_Behring _:B6005b15c6cea0ef5b1dafd2c054c3af0|rdf:type|obo:NCIT_C53285 imgt:Product_5fa85db2-30f3-3bc1-b3dd-17ad4f3c942c|rdf:type|obo:NCIT_C51980 imgt:CO-PART2|rdf:type|imgt:RegionLabel imgt:StudyProduct_fe683cf1-3e60-38cf-9475-d6d80b127665|rdf:type|obo:NCIT_C174271 imgt:StudyProduct_ff02fdb0-13d8-318a-af5f-902f811d122b|imgt:development_technology| Dyax human antibody phage display library imgt:mAb_291|imgt:inn_name|elotuzumab imgt:Clone_1288|imgt:isOriginCloneOf|imgt:mAb_1288 _:Bd5cff0fc98228a53d808a94b25a46a76|imgt:isDecidedBy|imgt:FDA imgt:Product_94ff4548-cf82-3333-b651-af7954d824c6|rdfs:label|Product_94ff4548-cf82-3333-b651-af7954d824c6 imgt:FUSION-DIPHTERIATOXIN-IL2|skos:definition|Diphtheria toxin imgt:StudyProduct_1b3acf71-6e7a-342f-9ae4-3094329da9f9|imgt:development_technology| Chimeric antigen receptor (CAR) T cell engineering imgt:hasStudyProduct|rdfs:label|hasStudyProduct imgt:9953|imgt:isImgtStructureEntryOf|imgt:mAb_788 imgt:Tenosynovitis|rdfs:label|Tenosynovitis imgt:StudyProduct_bbea2f88-7f15-3d18-9512-fe5918bb83a0|imgt:hasClinicalIndication|imgt:Solid_tumors imgt:StudyProduct_64e82bf7-3479-3db0-b7ab-3c08257b473f|imgt:hasClinicalIndication|imgt:Solid_tumors _:B4c9a1814589ca7ff91731cffc5d9eee9|imgt:hasDesignation|imgt:Orphan_drug imgt:Construct_222|imgt:hasImgtLabel|imgt:F(ab%27)2-G1-nd imgt:NUMEROTATION|rdfs:label|NUMEROTATION 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imgt:imgt_note|rdfs:label|imgt_note imgt:Product_262ab471-0054-380f-bcca-d0e91b8d0a82|imgt:commun_name|moxetumomab pasudotox -tdfk imgt:StudyProduct_9b348c98-7f02-303c-a16d-d7c0e68400ab|rdf:type|obo:NCIT_C174271 imgt:Segment_413_2|obo:BFO_0000050|imgt:Construct_413 imgt:Segment_625_1|rdf:type|imgt:Segment imgt:Construct_1015|imgt:hasImgtLabel|imgt:IgG4-kappa imgt:mAb_783|imgt:inn_number|10882 imgt:Segment_756_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:10999|rdfs:label|10999 imgt:StudyProduct_24f7a218-01dc-3469-b000-c47934d7f395|imgt:hasClinicalPhase|imgt:Phase_II imgt:Product_f52c4e93-a3d8-3f9a-8d2d-a623f5505e33|imgt:hasStudyProduct|imgt:StudyProduct_80b6bae5-6806-3ea3-9165-3cff6fbac3e8 imgt:mAb_612|imgt:imgt_note| HM10460A (G-CSF-Fc-PEG, Long-acting G-CSF analog), developed by Hanmi Pharmaceutical Seoul, Korea, is currently in Phase III by Spectrum Pharmaceuticals, Inc. \r (Hanmi Pharmaceutical pipeline ; ClinicalTrials.gov ). imgt:CD70|obo:RO_0002162|imgt:Homsap 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imgt:mAb_367|imgt:imgt_link|https://www.imgt.org/mAb-DB/mAbcard?AbId=367 imgt:Segment_1098_1|imgt:hasImgtLabel|imgt:AXL _:B6c0e3dfb428e18cb60a1ed48a1479f8f|imgt:hasDesignation|imgt:Orphan_drug _:Bee448fd151a94d6b508e22a7e73d08e5|imgt:hasStatut|imgt:approval imgt:Product_b53d5313-835d-3d6b-8fb3-a4650e3a36ef|imgt:isProducedBy|imgt:National_Institute_of_Allergy_and_Infectious_Diseases_(NIAID) imgt:Unilever|rdf:type|obo:NCIT_C54131 imgt:StudyProduct_d51f2da4-db5f-3ef5-be58-0680a7bca194|imgt:isStudyProductOf|imgt:Product_0ca89df9-4af8-318a-82c3-74e6893c18d2 imgt:StudyProduct_baa41ac1-2853-3eba-ae43-e487b5c0b4c0|rdf:type|obo:NCIT_C174271 imgt:IgG1-kappa_1026|imgt:isMabReceptorOf|imgt:mAb_1026 imgt:Product_c1583c88-e53a-3e51-9a2c-fabecf1e8960|imgt:commun_name|4F2 imgt:Segment_810_1|imgt:hasImgtLabel|imgt:IgG1-kappa imgt:StudyProduct_9282dfd1-9bea-3b0f-8a57-206f14824065|imgt:hasClinicalIndication|imgt:Graves'_orbitopathy_(GO) imgt:StudyProduct_17c276c8-e723-3b46-aef5-76537e9d56d0|rdfs:label|StudyProduct_17c276c8-e723-3b46-aef5-76537e9d56d0 imgt:StudyProduct_30086b40-1961-324c-b4da-8f5853b139be|imgt:application_type|Therapeutic imgt:mAb_611|imgt:imgt_note| IMP321 is an APC activator used in chemo-immunotherapy combination (breast cancers) Oct 7, 2013: Eddingpharm was granted exclusive rights for manufacturing and marketing IMP 321 in mainland China, Hong Kong, Macau and Taiwan. In 2014, Immutep was acquired by Prima BioMed. imgt:IgG1-kappa_MM_1|obo:RO_0002162|imgt:Musmus imgt:Product_0c9f5d50-b81e-3ee8-93bc-e8be40fcc398|imgt:isProducedBy|imgt:Roche_F_Hoffmann-La_Roche_Ltd imgt:Construct_499|obo:BFO_0000051|imgt:Segment_499_1 imgt:HIV-1_infection_AIDS|imgt:isClinicalIndicationOf|imgt:StudyProduct_98be9812-135f-3199-8453-fb46a2954524 pubmed:1903536|dc:title|Reshaping a therapeutic CD4 antibody imgt:Clone_939|rdfs:label|Clone_939 imgt:mAb_1148|imgt:hasProduct|imgt:Product_c7e9a862-4b9c-3df3-ad3b-aeec4b6fcd87 imgt:mAb_142|imgt:hasProduct|imgt:Product_da735f8d-c000-3a8c-a8be-647e0245f938 imgt:Product_3eac3ad8-0e0e-3905-b495-238bcb77e9cc|rdfs:label|Product_3eac3ad8-0e0e-3905-b495-238bcb77e9cc imgt:ADRB2_(Pr1-413)|rdf:type|imgt:DomainLabel imgt:Product_1d32d5b1-99c8-31ab-9a21-acfa4c132ab7|imgt:isProductOf|imgt:mAb_306 imgt:Product_557d6f3c-8aa3-35e6-bb7d-6df5196f42e8|imgt:isProductOf|imgt:mAb_118 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imgt:Lymphoma_diffuse_large_B_cell_(DLBCL)|imgt:isClinicalIndicationOf|imgt:StudyProduct_5f24239e-1e10-32d1-8b60-8abd532e4dd8 imgt:StudyProduct_38804e2c-8020-32ad-8f9e-7e0a6981e8ab|imgt:hasClinicalPhase|imgt:Phase_M imgt:Product_58163f7c-6428-37b2-b8ea-0d3a1c1187a0|rdf:type|obo:NCIT_C51980 imgt:BioNTech_SE|rdf:type|obo:NCIT_C54131 imgt:IgG1-kappa_813|imgt:hasMolecularComponent|imgt:IG imgt:Product_4eb1994b-05ee-3d18-a5e3-e16b2601a5cd|imgt:commun_name|hP67.6 (naked) imgt:FPIA_%5BPROTEIN-PROTEIN-PROTEIN-PROTEIN%5D2-FC_1158|http://semanticscience.org/resource/SIO_000291|imgt:VEGFA imgt:StudyProduct_7df31001-106b-3fe6-bdaf-f3aa6220ebee|rdfs:label|StudyProduct_7df31001-106b-3fe6-bdaf-f3aa6220ebee imgt:2V-LIKE|rdfs:label|2V-LIKE pubmed:16139892|dc:contributor|Kufer P imgt:SCFV-KAPPA-HEAVY-H-CH2-CH3|rdfs:label|SCFV-KAPPA-HEAVY-H-CH2-CH3 imgt:FAB-ALPHA-2_LAMBDA|rdf:type|imgt:IGProteolyticFragmentLabel imgt:F(ab’)2-Alpha-1_Kappa|imgt:isDescribedBy|imgt:F(AB')2-ALPHA-1_KAPPA imgt:Construct_666|rdf:type|imgt:Construct imgt:Product_8aedac6e-b419-31fb-9ff4-442f5cc9176a|imgt:isProducedBy|imgt:Teva_Pharmaceutical_Industries_Ltd_(Cephalon) imgt:mAb_502|rdf:type|imgt:INN imgt:StudyProduct_acb91568-6d59-3391-b836-4a871624d002|rdfs:label|StudyProduct_acb91568-6d59-3391-b836-4a871624d002 imgt:StudyProduct_f9ce6b2c-d9b5-35be-84a6-8e4b5898c49b|imgt:hasClinicalIndication|imgt:Secondary_cataract imgt:mAb_369|rdf:type|imgt:INN imgt:StudyProduct_fb04dcf4-fa40-31d0-b04d-bb8c0ffd8ade|imgt:isStudyProductOf|imgt:Product_94b8ef04-33ad-342d-a8f0-5d3313872f31 imgt:FPIA_%5BPROTEIN%5D2-FC_1227|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/FPIA_[PROTEIN]2-FC.png imgt:Construct_431|rdf:type|imgt:Construct imgt:Psoriatic_arthritis_(PSA)|imgt:isClinicalIndicationOf|imgt:StudyProduct_b15fa3dc-8f6b-39f0-a55e-0a40742c248c imgt:StudyProduct_8037ac88-b353-3582-afaf-b797db588a1b|imgt:hasClinicalIndication|imgt:Allograft_rejection imgt:H2|skos:definition|hinge exon 2 of IG heavy C-GENE-UNIT imgt:Fab-Gamma-3_Lambda|rdf:type|imgt:ReceptorType imgt:mAb_1276|imgt:inn_name|pelgifatamab imgt:IgG1-kappa_MM_540|imgt:hasMolecularComponent|imgt:IG imgt:Product_3d84c16b-3f37-3fd2-9308-fb662b4b198e|imgt:hasStudyProduct|imgt:StudyProduct_70af1ad9-fd1c-3cd9-90bd-29309d4e1b92 imgt:bispecific|imgt:isTargetOf|imgt:scFv-scFv-scFc_lambda_1200 imgt:IgG1-kappa-4lys-drug_52|rdfs:comment|IgG1 - kappa - 4lys - drug imgt:SCFV-HEAVY-KAPPA-SCFV-HEAVY-LAMBDA-CH2-CH3-CH2-CH3|skos:definition|scFv comprising a V-KAPPA, a V-LAMBDA and a VH, CH2,CH3 domains imgt:mAb_110|imgt:hasOriginClone|imgt:Clone_110 imgt:Clone_1056|imgt:isOriginCloneOf|imgt:mAb_1056 imgt:StudyProduct_f50ee431-70f4-33e4-8ada-f65929afb9ef|rdfs:label|StudyProduct_f50ee431-70f4-33e4-8ada-f65929afb9ef imgt:Construct_79|rdfs:label|Construct_79 imgt:IG-ALPHA_KAPPA|rdfs:label|IG-ALPHA_KAPPA imgt:Segment_699_1|obo:BFO_0000050|imgt:Construct_699 imgt:Segment_732_2|obo:BFO_0000050|imgt:Construct_732 imgt:IgG4-kappa-protein_1019|http://xmlns.com/foaf/0.1/depiction|https://www.imgt.org/images/mabdb/formats/IgG4-kappa-protein.png imgt:StudyProduct_6418f006-4cac-3121-b996-6d1a74606cd0|imgt:application_type|Therapeutic imgt:Segment_830_1|rdf:type|imgt:Segment