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Neuron is a Python project that allows an application's GUI to be built with HTML and Javascript.
It's simply a sample project that is ready to be downloaded and modified to become YOUR application.
This project just combines different projects together with an installer.

CEF Python, wxPython, Flask

wxPython - Windowing
CEF Python - Portable browser
Flask - Local web server
Gevent - Launches Flask
Bootstrap - Web UI
xmlhttprequest - Communication with Flask to update UI

How to Use

Get Started


Clone this repo

Setup Environment

Python 3.7

pip install -r requirements

Test Application

cd into the repo folder.
Start the application to make sure everything is working python -m neuron
The application comes with a sample GUI with some interactions with the backend.
The included HTML and Javascript functions are a sample of how actions can be performed.

Understanding Structure

Starts the application. It is a cefpython (portable chrome browser) application, and the windowing system.
It calls a function called find_port() which finds an open port on the local machine.
It then calls the function start_server() which starts the Flask web server.

This file is used to run gevent which handles running Flask and the incoming connections from your web gui.
start_gevent is importing the Flask application from

This is the Flask application. This is where routing for http calls will be, creating the HTML, and the backend of the application.
This is where main part of the application is handled.

Fields that contain your application name and related information.

Configures paths for the application.
Contains functions for getting and creating paths for your application.

Templates directory

Contains the HTML files for the application

Static directory

Contains the resources for the HTML files. Fonts, images, javascript libraries etc.

Rebrand Project

Windowing and Icons

The top of sets the size of the application.
icon.ico is the icon used by the window.

When creating an icon, you can bundle multiple sizes together to ensure it appears nicely at different sizes.
You can download icobundle to combine the icons into one file.
You can use this command. It also shows the different sizes you should create (eg icon24.ico is the 24x24 pixels size)
.\icobundl.exe -o icon.ico icon16.ico icon24.ico icon32.ico icon40.ico icon48.ico icon64.ico icon96.ico icon128.ico icon256.ico

Name, version etc


Modifying the Application

After rebranding the project, development on the new application can begin.

Main Program Logic is the Flask application that controls the main logic of the application.
Sample AJAX functions are included in the HTML to communicate with the backend Flask application.


Bootstrap is used for the HTML. This is not required, any HTML can be used.
Modifying the files in the templates and static directories will allow you change the GUI.
You call run python and go to localhost:5000 in your browser to work on your application without having to execute
templates/index.html contains Javascript calls to the backend to retrieve data.

Create Windows Executable and Installer

PyInstaller and exe

An exe for the application is created with PyInstaller.
build/build.spec is the PyInstaller spec which configures PyInstaller.
Extra files and directories to include (eg icon.ico) are set in the spec file.
To prevent the console window from appearing set EXE(console=False).

NSIS installer

Install NSIS

The installer is created with nsis.
build/installer.nsi is the template that will be automatically modified when creating a new build.
Modify build/icon.ico and build/header.bmp for your application.
Modify build/license.txt to be the contents of your application's license.
Modify the fields at the top of build/

Create new build

$ cd build/
$ python

This will run pyinstaller to create the exe, copy it into build/dist/, and then create the installer with nsis.
A file containing multiple hashes of the installer is also created.


  • requirements.txt minimum versions show what was tested with


CEFPython - Python bindings for the Chromium Embedded Framework
Flask - Python microframework
Bootstrap - Web Front-End Framework
PyInstaller - Turn Python projects into executables
NSIS - Creates installer


Neuron Screenshot


The license for this project is the MIT License