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@ajbaird ajbaird released this Mar 12, 2018 · 5 commits to master since this release

What's new in ver 6.3 (March 1, 2018)

The latest deployment includes the following notable updates:

  • General bug fixes, system improvements, and tools/solver improvements
  • Fasciculation patient event flags
  • Updated sweat methodology (fixes to ions lost in sweat)
  • Updated substance and compound infusion functionality
    • Added Ringers lactate and updated
    • Saline compound ion concentrations corrected
    • Hardened implementation
  • MuscleMass new patient data request
    • Muscle catabolism patient flag
  • Added dehydration condition
    • Implemented as scalar 0to1 representing fractional total body water lost
    • Fluid removed from patient compartments
    • Updated patient flag for event and track body weight change (validated)
    • Added totalbodyfluidVolume as data request
    • Updated patient weight as a function of condition
  • Added starvation condition
    • TimeSinceMeal determines how long since the patient's last meal
    • Scales internal nutrient storages from validated starvation data
    • Removed ConsumeMeal condition, now replaced by starvation condition
    • Validated blood concentrations for ketones, glucose, and amino acids
    • Updated patient weight as a function of condition
  • Intracellular ion transport
    • Model uses membrane potential (see @ref TissueMethodology for details)
    • Michaelis coefficient could support more ion regulation in the future
    • Gated ion transport allows for differences between intra/extracellular spaces
  • COPD now supports elevated anaerobic metabolism
  • Ion transport model in the small intestine
  • Updated drug library so all drugs support an effects site transport rate
  • Diabetes type 1 and type 2 conditions
    • insulin resistance and insulin production effects
  • Hemorrhage action now initialized with a 0-1 severity and a location (MCIS SDK example still exists)
  • New drug Vasopressin
  • New drug classifications in the CDM for better grouping in-code
    • Include anesthetic, sedative, opioid, and reversal agent
    • More grouping in future work
Assets 15

@ajbaird ajbaird released this Sep 28, 2017 · 24 commits to master since this release

What's new in version 6.2 (September 28, 2017)

The latest deployment includes the following notable updates:

  • General bug fixes, system improvements, and tools/solver improvements
  • Intoxication model for Morphine
    • Effects site concentration to allow for delayed PD reactions
    • Central nervous modifier to model depressed feedback mechanisms
    • Noloxone reversal agent model
  • New Hemorrhage model
    • MCIS support for combat injury coding
    • Location and severity can be flagged through MCIS
    • Resistance paths handle bleed out to simulate more realistic flow behavior
  • Glucagon hormone
  • New nutrient kinetics model
    • New metabolic production and consumption method
    • Protein storage and release model (amino acids in muscle)
    • Fat storage and release model
    • Interactions with the Hepatic system
  • New Hepatic system
    • Maintains blood glucose from other substances like lactate through new gluconeogenesis method
    • Lipogenesis method generates triacylglycerol due to excess glucose and amino acid
    • Glycogenesis and glycogenolysis to maintain blood glucose levels
  • Updated exercise model
    • Coupled to nutrient kinetic handling and metabolic need
  • Updated diffusion method
  • New Gastrointestinal model
    • Enzyme kinetics determine digestion of nutrients
    • Absorption facilitated through sodium co-transporter
    • Gastric secretion function allows for bile formation in chyme
  • Desflurane update and fix
Assets 15
Jun 16, 2017
linked readme to code of conduct
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