diff --git a/.github/workflows/build.yml b/.github/workflows/build.yml
index a288066..1bbc7e2 100644
--- a/.github/workflows/build.yml
+++ b/.github/workflows/build.yml
@@ -19,10 +19,10 @@ jobs:
       - uses: actions/checkout@v2
         with:
           fetch-depth: 0
-      - name: Set up Python 3.6
+      - name: Set up Python 3.7
         uses: actions/setup-python@v2
         with:
-          python-version: 3.6
+          python-version: 3.7
       - name: Build a source tarball and wheel
         run: |
             pip install wheel
diff --git a/.github/workflows/test.yml b/.github/workflows/test.yml
index 7647379..b1b8e7c 100644
--- a/.github/workflows/test.yml
+++ b/.github/workflows/test.yml
@@ -10,7 +10,7 @@ jobs:
     runs-on: ubuntu-latest
     strategy:
       matrix:
-        python-version: ["3.6", "3.7", "3.8", "3.9", "3.10"]
+        python-version: ["3.7", "3.8", "3.9", "3.10"]
 
     steps:
     - uses: actions/checkout@v2
diff --git a/README.md b/README.md
index ef30e64..4e9d0ec 100644
--- a/README.md
+++ b/README.md
@@ -83,7 +83,7 @@ This software is citable using a [DOI generated by Zenodo](https://zenodo.org/re
 Requirements
 ============
 
-* [Python 3.6+](https://www.python.org/downloads/release/python-360/)
+* [Python 3.7+](https://www.python.org/downloads/release/python-360/)
 * [eFEL eFeature Extraction Library](https://github.com/BlueBrain/eFEL) (automatically installed by pip)
 * [Numpy](http://www.numpy.org) (automatically installed by pip)
 * [Scipy](https://www.scipy.org/) (automatically installed by pip)
diff --git a/setup.py b/setup.py
index 385f2c7..23d0044 100644
--- a/setup.py
+++ b/setup.py
@@ -35,6 +35,7 @@
     "format that can then be used by BluePyOpt for electrical model building "
     "purposes.",
     packages=setuptools.find_packages(),
+    python_requires=">=3.7",
     include_package_data=True,
     author="BlueBrain Project, EPFL",
     license="LGPLv3",
diff --git a/tox.ini b/tox.ini
index 15c8a22..b47a162 100644
--- a/tox.ini
+++ b/tox.ini
@@ -3,7 +3,6 @@ envlist = py3-{functional,style}
 
 [gh-actions]
 python =
-    3.6: py3
     3.7: py3
     3.8: py3
     3.9: py3
@@ -11,7 +10,7 @@ python =
 
 [testenv]
 envdir =
-    py3{5,6,7,8,9,10,}{-functional,-notebooks,-style,-syntax,-docs,-upload_docs}: {toxworkdir}/py3
+    py3{7,8,9,10,}{-functional,-notebooks,-style,-syntax,-docs,-upload_docs}: {toxworkdir}/py3
 usedevelop = true
 deps =
     coverage