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No Read Left Behind - Software for Motif Discovery from SELEX Data
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No Read Left Behind (NRLB)

This repository contains code for building and using accurate biophysical models for protein-DNA interaction. More information can be found in the following paper: Rastogi C, et al. (2018) Accurate and sensitive quantification of protein-DNA binding affinity. PNAS 115(16):E3692-E3701 (

There are two distinct components to this repository:

  • ModelFitting : commandline tools for building NRLB models (mostly intended for experts)
  • R-package/NRLBtools : user-friendly R package that contains all models discussed in Rastogi et al. (2018)
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