TADpole: identifying and analyzing the hierarchy of TADs

external link: https://github.com/3DGenomes/TADpole

developed by Marti-Renom Laboratory at CNAG-CGR

Description

TADpole, a computational tool designed to identify and analyze the entire hierarchy of TADs in intra-chromosomal in- teraction matrices. TADpole combines principal com- ponent analysis and constrained hierarchical clustering to provide a set of significant hierarchical chromatin levels in a genomic region of interest.

How to cite

Soler-Vila, P., Cusco Pons, P., Farabella, I., Di Stefano, M. and Marti-Renom, M.A. "Hierarchical chromatin organization detected by TADpole." Nucleic Acids Research (2020) gkaa087