diff --git a/setup.py b/setup.py
index 7fffb43a..5f034299 100644
--- a/setup.py
+++ b/setup.py
@@ -55,7 +55,7 @@
     extras_require={
         "vcf": [
             "cyvcf2==0.10.1; python_version < '3.7'",
-            "numpy==1.21.3",
+            "numpy==1.21.4",
             "cyvcf2; python_version >= '3.7'",
             "Cython==0.29.24",
         ],