diff --git a/src/index.ts b/src/index.ts
index 7acfa49..60cb719 100644
--- a/src/index.ts
+++ b/src/index.ts
@@ -15,6 +15,10 @@ export type {
   MouseOverParams,
 } from './types';
 
+// useChartGPU hook (Story 6.19)
+export { useChartGPU } from './useChartGPU';
+export type { UseChartGPUResult } from './useChartGPU';
+
 /**
  * @deprecated Use `ChartGPU` instead. `ChartGPUChart` is kept for backward compatibility.
  * Will be removed in a future major version.
diff --git a/src/useChartGPU.ts b/src/useChartGPU.ts
new file mode 100644
index 0000000..d7934bb
--- /dev/null
+++ b/src/useChartGPU.ts
@@ -0,0 +1,186 @@
+import { useEffect, useRef, useState } from 'react';
+import { ChartGPU as ChartGPULib } from 'chartgpu';
+import type { ChartGPUOptions } from 'chartgpu';
+import type { ChartInstance } from './types';
+
+/**
+ * Result object returned by the useChartGPU hook.
+ */
+export interface UseChartGPUResult {
+  /**
+   * The ChartGPU instance once initialized, null before initialization.
+   */
+  chart: ChartInstance | null;
+
+  /**
+   * True when the chart has been successfully initialized and is ready to use.
+   */
+  isReady: boolean;
+
+  /**
+   * Error object if initialization failed or WebGPU is not supported.
+   * Null when no error has occurred.
+   */
+  error: Error | null;
+}
+
+/**
+ * Debounce utility for throttling frequent calls.
+ */
+function debounce<T extends (...args: any[]) => void>(
+  fn: T,
+  delayMs: number
+): (...args: Parameters<T>) => void {
+  let timeoutId: ReturnType<typeof setTimeout> | null = null;
+  return (...args: Parameters<T>) => {
+    if (timeoutId !== null) {
+      clearTimeout(timeoutId);
+    }
+    timeoutId = setTimeout(() => {
+      fn(...args);
+    }, delayMs);
+  };
+}
+
+/**
+ * React hook for managing a ChartGPU instance.
+ *
+ * Provides lifecycle management, automatic resize handling, and error handling
+ * for ChartGPU charts in React applications.
+ *
+ * Features:
+ * - Async initialization with StrictMode safety
+ * - WebGPU support detection
+ * - Automatic resize handling via ResizeObserver (debounced 100ms)
+ * - Options updates via setOption
+ * - Proper cleanup on unmount
+ *
+ * @param containerRef - React ref to the container element where the chart will be rendered
+ * @param options - ChartGPU configuration options
+ * @returns Object containing chart instance, ready state, and error state
+ *
+ * @example
+ * ```tsx
+ * const containerRef = useRef<HTMLDivElement>(null);
+ * const { chart, isReady, error } = useChartGPU(containerRef, {
+ *   series: [{ type: 'line', data: [...] }],
+ *   xAxis: { type: 'linear' },
+ *   yAxis: { type: 'linear' }
+ * });
+ *
+ * if (error) return <div>WebGPU not supported</div>;
+ * if (!isReady) return <div>Loading...</div>;
+ *
+ * return <div ref={containerRef} style={{ width: '100%', height: '400px' }} />;
+ * ```
+ */
+export function useChartGPU(
+  containerRef: React.RefObject<HTMLElement>,
+  options: ChartGPUOptions
+): UseChartGPUResult {
+  const [chart, setChart] = useState<ChartInstance | null>(null);
+  const [isReady, setIsReady] = useState(false);
+  const [error, setError] = useState<Error | null>(null);
+
+  const mountedRef = useRef<boolean>(false);
+  const resizeObserverRef = useRef<ResizeObserver | null>(null);
+
+  // Initialize chart on mount
+  useEffect(() => {
+    // WebGPU support check
+    if (!('gpu' in navigator)) {
+      setError(new Error('WebGPU not supported in this browser'));
+      return;
+    }
+
+    if (!containerRef.current) {
+      return;
+    }
+
+    mountedRef.current = true;
+    let chartInstance: ChartInstance | null = null;
+
+    const initChart = async () => {
+      try {
+        if (!containerRef.current) return;
+
+        chartInstance = await ChartGPULib.create(
+          containerRef.current,
+          options
+        );
+
+        // StrictMode safety: only update state if still mounted
+        if (mountedRef.current) {
+          setChart(chartInstance);
+          setIsReady(true);
+          setError(null);
+        } else {
+          // Component unmounted during async create - dispose immediately
+          chartInstance.dispose();
+        }
+      } catch (err) {
+        if (mountedRef.current) {
+          // Normalize error to Error instance
+          const normalizedError =
+            err instanceof Error ? err : new Error(String(err));
+          setError(normalizedError);
+          setIsReady(false);
+        }
+      }
+    };
+
+    initChart();
+
+    // Cleanup on unmount
+    return () => {
+      mountedRef.current = false;
+      setIsReady(false);
+
+      if (chartInstance && !chartInstance.disposed) {
+        chartInstance.dispose();
+      }
+
+      if (resizeObserverRef.current) {
+        resizeObserverRef.current.disconnect();
+        resizeObserverRef.current = null;
+      }
+    };
+    // Intentionally omitting containerRef.current from dependencies to avoid re-initialization
+    // eslint-disable-next-line react-hooks/exhaustive-deps
+  }, []);
+
+  // Update chart when options change
+  useEffect(() => {
+    if (!chart || chart.disposed) return;
+
+    chart.setOption(options);
+  }, [chart, options]);
+
+  // Set up ResizeObserver for responsive sizing (debounced 100ms)
+  useEffect(() => {
+    const container = containerRef.current;
+    if (!chart || chart.disposed || !container) return;
+
+    const debouncedResize = debounce(() => {
+      if (chart && !chart.disposed) {
+        chart.resize();
+      }
+    }, 100);
+
+    const observer = new ResizeObserver(() => {
+      debouncedResize();
+    });
+
+    observer.observe(container);
+    resizeObserverRef.current = observer;
+
+    return () => {
+      observer.disconnect();
+      resizeObserverRef.current = null;
+    };
+    // Intentionally omitting containerRef.current from dependencies
+    // eslint-disable-next-line react-hooks/exhaustive-deps
+  }, [chart]);
+
+  return { chart, isReady, error };
+}