Skip to content

Clinical-Pharmacy-Saarland-University/PBPK-Models

Repository files navigation

PBPK-Models

Purpose

This repository contains the PBPK models published by the Clinical Pharmacy Saarland University working group. It is intended to provide the model files in their published state, meaning that all parameters should be true to the values reported in the respective publication or their Supplementary Materials.

Disclaimer

The models presented in this repository may not always be compatible with the current version of the Open Systems Pharmacology Suite due to software changes. However, the models are compatible with the Version reported in the respective publication. Older releases of the Open Systems Pharmacology Suite can be found in the OSP repository under "releases".

Usage

To access all models presented in this repo, you might need to have the git CLI installed. To recursively clone this repo and all models (submodules) run the following line in your git CLI:

git clone https://github.com/Clinical-Pharmacy-Saarland-University/PBPK-Models --recurse-submodules

Models

The models published by the Clinical Pharmacy Saarland University working group are listed below.

Model OSPSuite Version Author, Year doi
Atomoxetine v10 (published) Rüdesheim et al. 2022 doi.org/10.3390/pharmaceutics14081734
Bupropion v9.1 (published) Marok et al. 2021 doi.org/10.3390/pharmaceutics12121200
Carbamazepine v9.1 (published) Fuhr et al. 2021 doi.org/10.3390/pharmaceutics13020270
Clopidogrel v9.1 (published) Loer et al. 2022 doi.org/10.3390/pharmaceutics14050915
Dextromethorphan v9.1 (published) Rüdesheim et al. 2022 doi.org/10.1002/psp4.12776
E-clomiphene v11.2 (published) Kovar et al. 2022 doi.org/10.3390/pharmaceutics14122604
Felodipine v9.1 (published) Fuhr et al. 2022 doi.org/10.3390/pharmaceutics14071474
5-FU v9.1 (published) Marok et al. 2024 doi.org/10.1002/cpt.3181
Imatinib v11.0 (published) Loer et al. 2024 doi.org/10.1002/psp4.13127
Ketoconazole v11.0 (published) Marok et al. 2023 doi.org/10.3390/pharmaceutics15020679
Metoprolol v9.1 (published) Rüdesheim et al. 2020 doi.org/10.3390/pharmaceutics13030331
Paroxetine v10 (published) Rüdesheim et al. 2022 doi.org/10.3390/pharmaceutics14081734
Quinidine v11.0 (published) Feick et al. 2023 doi/10.1002/psp4.12981
Risperidone v10 (published) Rüdesheim et al. 2022 doi.org/10.3390/pharmaceutics14081734
Simvastatin v8.0 (published) Wojtyniak et al. 2021 doi.org/10.1002/cpt.2111
Tacrolimus v10 (published) Loer et al. 2023 doi.org/10.1002/psp4.12946
Verapamil-Norverapamil v8.1 (published) Hanke et al. 2020 doi.org/10.3390/pharmaceutics12060556

About

No description, website, or topics provided.

Resources

Stars

Watchers

Forks

Releases

No releases published

Packages