PBPK-Models

Purpose

This repository contains the PBPK models published by the Clinical Pharmacy Saarland University working group. It is intended to provide the model files in their published state, meaning that all parameters should be true to the values reported in the respective publication or their Supplementary Materials.

Disclaimer

The models presented in this repository may not always be compatible with the current version of the Open Systems Pharmacology Suite due to software changes. However, the models are compatible with the Version reported in the respective publication. Older releases of the Open Systems Pharmacology Suite can be found in the OSP repository under "releases".

Usage

To access all models presented in this repo, you might need to have the git CLI installed. To recursively clone this repo and all models (submodules) run the following line in your git CLI:

git clone https://github.com/Clinical-Pharmacy-Saarland-University/PBPK-Models --recurse-submodules

Models

The models published by the Clinical Pharmacy Saarland University working group are listed below.

Model	OSPSuite Version	Author, Year	doi
Atomoxetine	v10 (published)	Rüdesheim et al. 2022	doi.org/10.3390/pharmaceutics14081734
Bupropion	v9.1 (published)	Marok et al. 2021	doi.org/10.3390/pharmaceutics12121200
Carbamazepine	v9.1 (published)	Fuhr et al. 2021	doi.org/10.3390/pharmaceutics13020270
Clopidogrel	v9.1 (published)	Loer et al. 2022	doi.org/10.3390/pharmaceutics14050915
Dextromethorphan	v9.1 (published)	Rüdesheim et al. 2022	doi.org/10.1002/psp4.12776
E-clomiphene	v11.2 (published)	Kovar et al. 2022	doi.org/10.3390/pharmaceutics14122604
Felodipine	v9.1 (published)	Fuhr et al. 2022	doi.org/10.3390/pharmaceutics14071474
5-FU	v9.1 (published)	Marok et al. 2024	doi.org/10.1002/cpt.3181
Imatinib	v11.0 (published)	Loer et al. 2024	doi.org/10.1002/psp4.13127
Ketoconazole	v11.0 (published)	Marok et al. 2023	doi.org/10.3390/pharmaceutics15020679
Metoprolol	v9.1 (published)	Rüdesheim et al. 2020	doi.org/10.3390/pharmaceutics13030331
Paroxetine	v10 (published)	Rüdesheim et al. 2022	doi.org/10.3390/pharmaceutics14081734
Quinidine	v11.0 (published)	Feick et al. 2023	doi/10.1002/psp4.12981
Risperidone	v10 (published)	Rüdesheim et al. 2022	doi.org/10.3390/pharmaceutics14081734
Simvastatin	v8.0 (published)	Wojtyniak et al. 2021	doi.org/10.1002/cpt.2111
Tacrolimus	v10 (published)	Loer et al. 2023	doi.org/10.1002/psp4.12946
Verapamil-Norverapamil	v8.1 (published)	Hanke et al. 2020	doi.org/10.3390/pharmaceutics12060556