LASSIE is a statistical model for inferring selection coefficients associated with coding variants in the human genome. Details of the LASSIE model are available on bioRxiv (https://www.biorxiv.org/content/early/2018/10/13/441337).
Precomputed LASSIE scores
Precomputed LASSIE scores (selection coefficients) are available for all potential coding variants in the human genome (hg19 assembly):
Selection coefficient file: http://compgen.cshl.edu/~yihuang/LASSIE/LASSIE_fitness_effect_hg19.tsv.gz