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LASSIE_MDN.py
LASSIE_PRF.py
README.md
hidden_layer.py
selection_layer.py

README.md

Synopsis

LASSIE is a statistical model for inferring selection coefficients associated with coding variants in the human genome. Details of the LASSIE model are available on bioRxiv (https://www.biorxiv.org/content/early/2018/10/13/441337).

Precomputed LASSIE scores

Precomputed LASSIE scores (selection coefficients) are available for all potential coding variants in the human genome (hg19 assembly):

Selection coefficient file: http://compgen.cshl.edu/~yihuang/LASSIE/LASSIE_fitness_effect_hg19.tsv.gz

Index file: http://compgen.cshl.edu/~yihuang/LASSIE/LASSIE_fitness_effect_hg19.tsv.gz.tbi

Documentation

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