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The Potential Drug-drug Interaction and Potential Drug-drug Interaction Evidence Ontology (DIDEO)

A new foundational representation of potential drug-drug interactions (PDDIs) that covers the material entities and processes in the domain of discourse for PDDI evidence and knowledge claims. The representation will enable the integration of drug interaction mechanisms, effects, risk factors, severity, and management options with the chemical and pharmacological properties (e.g., chemical structure, function, pharmacokinetic and pharmacodynamic properties) of the interacting drugs.

A description of the goals of the project can be found in the following workshop paper located in the docs/DIDEO-discussion-ICBO-Brochhausen-2014.pdf:

Brochhausen, M., Schneider, J., Malone, D., Empey, PE., Hogan WR., and Boyce, RD. Towards a foundational representation of potential drug-drug interaction knowledge. The 1st International Drug-Drug Interaction Knowledge Representation Workshop (DIKR 2014). Collocated with the 2014 International Conference on Biomedical Ontology (ICBO 2014). October 6th, Houston, Texas. United States.

Ontology development guidelines:

All development is done in the development OWL file located at development/dideo.owl There is a development purl, which always points to development file on the master branch.

The dideo.owl file in the base directory is the most recent release version and has the purl,


The DIDEO is made available under the Creative Commons Attribution 4.0 International Public License. A copy of the license is available in this code repository. You may also read a short summary of the license at or the full version at


  • Richard D. Boyce
  • Mathias Brochhausen
  • Philip E. Empey
  • William R. Hogan
  • John Judkins
  • Daniel C. Malone
  • Jodi Schneider


The Potential Drug-drug Interaction and Potential Drug-drug Interaction Evidence Ontology (DIDEO)




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