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L1 penalty terms can be used to detect cell type-specific parameters, triggering specific behavior of signaling pathways or gene regulatory networks. Such differences may reveal drug targets that selectively affect only malignant cells while leaving healthy cells unaffected.
- Steiert B., et al. L1 regularization facilitates detection of cell type-specific parameters in dynamical systems. Bioinformatics 32(17), i718-i726, 2016.
The benchmark model used in the publication is located in the folder
One example of identifying cell type-specific parameters is shown in the example application JAK2/STAT5 signaling model.