L1 regularization

bernhardsteiert edited this page Sep 3, 2016 · 4 revisions

L1 regularization

L1 penalty terms can be used to detect cell type-specific parameters, triggering specific behavior of signaling pathways or gene regulatory networks. Such differences may reveal drug targets that selectively affect only malignant cells while leaving healthy cells unaffected.

The benchmark model used in the publication is located in the folder /Examples/Dream6_L1.

One example of identifying cell type-specific parameters is shown in the example application JAK2/STAT5 signaling model.

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