diff --git a/ddtrace/profiling/profiler.py b/ddtrace/profiling/profiler.py
index de8b326ab1c..8b32ffa3415 100644
--- a/ddtrace/profiling/profiler.py
+++ b/ddtrace/profiling/profiler.py
@@ -73,7 +73,7 @@ def start(self, stop_on_exit=True, profile_children=True):
 
         if profile_children:
             try:
-                uwsgi.check_uwsgi(self.start, atexit=self.stop if stop_on_exit else None)
+                uwsgi.check_uwsgi(self._restart_on_fork, atexit=self.stop if stop_on_exit else None)
             except uwsgi.uWSGIMasterProcess:
                 # Do nothing, the start() method will be called in each worker subprocess
                 return
diff --git a/releasenotes/notes/profiling-fix-uwsgi-empty-profiles-7dbd5fdd93dea47f.yaml b/releasenotes/notes/profiling-fix-uwsgi-empty-profiles-7dbd5fdd93dea47f.yaml
new file mode 100644
index 00000000000..5afc2ac4934
--- /dev/null
+++ b/releasenotes/notes/profiling-fix-uwsgi-empty-profiles-7dbd5fdd93dea47f.yaml
@@ -0,0 +1,6 @@
+---
+fixes:
+  - |
+    In certain circumstances, the profiles generated in a uWSGI application
+    could have been empty. This is now fixed and the profiler records correctly
+    the generated events.
diff --git a/tests/profiling/exporter/test_file.py b/tests/profiling/exporter/test_file.py
index c3ad2e71198..20d96dcdc9a 100644
--- a/tests/profiling/exporter/test_file.py
+++ b/tests/profiling/exporter/test_file.py
@@ -2,7 +2,7 @@
 
 from ddtrace.profiling.exporter import file
 
-from .. import test_main
+from .. import utils
 from ..exporter import test_pprof
 
 
@@ -10,4 +10,4 @@ def test_export(tmp_path):
     filename = str(tmp_path / "pprof")
     exp = file.PprofFileExporter(filename)
     exp.export(test_pprof.TEST_EVENTS, 0, 1)
-    test_main.check_pprof_file(filename + "." + str(os.getpid()) + ".1")
+    utils.check_pprof_file(filename + "." + str(os.getpid()) + ".1")
diff --git a/tests/profiling/test_main.py b/tests/profiling/test_main.py
index 228a12b699f..bc04d33f8e5 100644
--- a/tests/profiling/test_main.py
+++ b/tests/profiling/test_main.py
@@ -1,10 +1,9 @@
-import gzip
 import os
 import subprocess
 
 import pytest
 
-from ddtrace.profiling.exporter import pprof_pb2
+from . import utils
 
 
 def call_program(*args):
@@ -38,15 +37,6 @@ def test_call_script_gevent(monkeypatch):
     assert exitcode == 0
 
 
-def check_pprof_file(filename):
-    with gzip.open(filename, "rb") as f:
-        content = f.read()
-    p = pprof_pb2.Profile()
-    p.ParseFromString(content)
-    assert len(p.sample_type) == 11
-    assert p.string_table[p.sample_type[0].type] == "cpu-samples"
-
-
 def test_call_script_pprof_output(tmp_path, monkeypatch):
     """This checks if the pprof output and atexit register work correctly.
 
@@ -58,17 +48,10 @@ def test_call_script_pprof_output(tmp_path, monkeypatch):
     monkeypatch.setenv("DD_PROFILING_ENABLED", "1")
     _, _, exitcode, pid = call_program("ddtrace-run", os.path.join(os.path.dirname(__file__), "simple_program.py"))
     assert exitcode == 42
-    check_pprof_file(filename + "." + str(pid) + ".1")
+    utils.check_pprof_file(filename + "." + str(pid) + ".1")
     return filename, pid
 
 
-def test_call_script_pprof_output_interval(tmp_path, monkeypatch):
-    monkeypatch.setenv("DD_PROFILING_UPLOAD_INTERVAL", "0.1")
-    filename, pid = test_call_script_pprof_output(tmp_path, monkeypatch)
-    for i in (2, 3):
-        check_pprof_file(filename + "." + str(pid) + (".%d" % i))
-
-
 def test_fork(tmp_path, monkeypatch):
     filename = str(tmp_path / "pprof")
     monkeypatch.setenv("DD_PROFILING_API_TIMEOUT", "0.1")
@@ -79,8 +62,8 @@ def test_fork(tmp_path, monkeypatch):
     )
     assert exitcode == 0
     child_pid = stdout.decode().strip()
-    check_pprof_file(filename + "." + str(pid) + ".1")
-    check_pprof_file(filename + "." + str(child_pid) + ".1")
+    utils.check_pprof_file(filename + "." + str(pid) + ".1")
+    utils.check_pprof_file(filename + "." + str(child_pid) + ".1")
 
 
 @pytest.mark.skipif(not os.getenv("DD_PROFILE_TEST_GEVENT", False), reason="Not testing gevent")
diff --git a/tests/profiling/test_uwsgi.py b/tests/profiling/test_uwsgi.py
index 754a7cebbe5..d612addc89f 100644
--- a/tests/profiling/test_uwsgi.py
+++ b/tests/profiling/test_uwsgi.py
@@ -10,12 +10,16 @@
 
 from tests.contrib.uwsgi import run_uwsgi
 
+from . import utils
+
 
 uwsgi_app = os.path.join(os.path.dirname(__file__), "uwsgi-app.py")
 
 
 @pytest.fixture
-def uwsgi():
+def uwsgi(monkeypatch):
+    # Do not ignore profiler so we have samples in the output pprof
+    monkeypatch.setenv("DD_PROFILING_IGNORE_PROFILER", "0")
     # Do not use pytest tmpdir fixtures which generate directories longer than allowed for a socket file name
     socket_name = tempfile.mktemp()
     cmd = ["uwsgi", "--need-app", "--die-on-term", "--socket", socket_name, "--wsgi-file", uwsgi_app]
@@ -43,7 +47,7 @@ def test_uwsgi_threads_enabled(uwsgi, tmp_path, monkeypatch):
     proc.terminate()
     assert proc.wait() == 30
     for pid in worker_pids:
-        assert os.path.exists("%s.%d.1" % (filename, pid))
+        utils.check_pprof_file("%s.%d.1" % (filename, pid))
 
 
 def test_uwsgi_threads_processes_no_master(uwsgi, monkeypatch):
@@ -85,7 +89,7 @@ def test_uwsgi_threads_processes_master(uwsgi, tmp_path, monkeypatch):
     proc.terminate()
     assert proc.wait() == 0
     for pid in worker_pids:
-        assert os.path.exists("%s.%d.1" % (filename, pid))
+        utils.check_pprof_file("%s.%d.1" % (filename, pid))
 
 
 def test_uwsgi_threads_processes_master_lazy_apps(uwsgi, tmp_path, monkeypatch):
@@ -98,7 +102,7 @@ def test_uwsgi_threads_processes_master_lazy_apps(uwsgi, tmp_path, monkeypatch):
     proc.terminate()
     assert proc.wait() == 0
     for pid in worker_pids:
-        assert os.path.exists("%s.%d.1" % (filename, pid))
+        utils.check_pprof_file("%s.%d.1" % (filename, pid))
 
 
 # For whatever reason this crashes easily on Python 2.7 with a segfault, and hangs on Python before 3.7.
@@ -154,4 +158,4 @@ def test_uwsgi_threads_processes_no_master_lazy_apps(uwsgi, tmp_path, monkeypatc
             except OSError:
                 break
     for pid in worker_pids:
-        assert os.path.exists("%s.%d.1" % (filename, pid))
+        utils.check_pprof_file("%s.%d.1" % (filename, pid))
diff --git a/tests/profiling/utils.py b/tests/profiling/utils.py
new file mode 100644
index 00000000000..a1bac533689
--- /dev/null
+++ b/tests/profiling/utils.py
@@ -0,0 +1,16 @@
+import gzip
+
+from ddtrace.profiling.exporter import pprof_pb2
+
+
+def check_pprof_file(
+    filename,  # type: str
+):
+    # type: (...) -> None
+    with gzip.open(filename, "rb") as f:
+        content = f.read()
+    p = pprof_pb2.Profile()
+    p.ParseFromString(content)
+    assert len(p.sample_type) == 11
+    assert p.string_table[p.sample_type[0].type] == "cpu-samples"
+    assert len(p.sample) >= 1