diff --git a/.changeset/tiny-dodos-juggle.md b/.changeset/tiny-dodos-juggle.md
new file mode 100644
index 00000000000..c721b667058
--- /dev/null
+++ b/.changeset/tiny-dodos-juggle.md
@@ -0,0 +1,5 @@
+---
+"effect": patch
+---
+
+Honor custom split and strip regular expressions passed to `String.noCase`.
diff --git a/packages/effect/src/String.ts b/packages/effect/src/String.ts
index 5bee588be46..ecf3d86e740 100644
--- a/packages/effect/src/String.ts
+++ b/packages/effect/src/String.ts
@@ -1234,15 +1234,20 @@ export const noCase: {
   readonly delimiter?: string | undefined
   readonly transform?: (part: string, index: number, parts: ReadonlyArray<string>) => string
 }): string => {
+  const splitRegExp = toRegExpArray(options?.splitRegExp ?? SPLIT_REGEXP)
+  const stripRegExp = toRegExpArray(options?.stripRegExp ?? STRIP_REGEXP)
   const delimiter = options?.delimiter ?? " "
   const transform = options?.transform ?? toLowerCase
-  return normalizeCase(input, SPLIT_REGEXP, STRIP_REGEXP, delimiter, transform)
+  return normalizeCase(input, splitRegExp, stripRegExp, delimiter, transform)
 })
 
+const toRegExpArray = (regexp: RegExp | ReadonlyArray<RegExp>): ReadonlyArray<RegExp> =>
+  predicate.isRegExp(regexp) ? [regexp] : regexp
+
 const normalizeCase = (
   input: string,
   splitRegExp: ReadonlyArray<RegExp>,
-  stripRegExp: RegExp,
+  stripRegExp: ReadonlyArray<RegExp>,
   delimiter: string,
   transform: (part: string, index: number, parts: ReadonlyArray<string>) => string
 ): string => {
@@ -1250,7 +1255,9 @@ const normalizeCase = (
   for (const regexp of splitRegExp) {
     result = result.replace(regexp, "$1\0$2")
   }
-  result = result.replace(stripRegExp, "\0")
+  for (const regexp of stripRegExp) {
+    result = result.replace(regexp, "\0")
+  }
   let start = 0
   let end = result.length
   // Trim the delimiter from around the output string.
@@ -1370,7 +1377,7 @@ export const constantCase: (self: string) => string = noCase({
  * @since 4.0.0
  */
 export const configCase: (self: string) => string = (self) =>
-  normalizeCase(self, CONFIG_SPLIT_REGEXP, STRIP_REGEXP, "_", toUpperCase)
+  normalizeCase(self, CONFIG_SPLIT_REGEXP, [STRIP_REGEXP], "_", toUpperCase)
 
 /**
  * Converts a string to kebab-case (lowercase with hyphens).
diff --git a/packages/effect/test/String.test.ts b/packages/effect/test/String.test.ts
index b0612ba9d86..26d43e5c852 100644
--- a/packages/effect/test/String.test.ts
+++ b/packages/effect/test/String.test.ts
@@ -634,6 +634,22 @@ describe("String", () => {
       strictEqual(pipe("helloWorld", S.noCase({ delimiter: "-" })), "hello-world")
     })
 
+    it("uses a custom split regular expression", () => {
+      strictEqual(S.noCase("ab", { splitRegExp: /([a])([b])/g }), "a b")
+    })
+
+    it("uses custom split regular expressions", () => {
+      strictEqual(S.noCase("abc", { splitRegExp: [/([a])([b])/g, /([b])([c])/g] }), "a b c")
+    })
+
+    it("uses a custom strip regular expression", () => {
+      strictEqual(S.noCase("a_b-c", { stripRegExp: /_/g }), "a b-c")
+    })
+
+    it("uses custom strip regular expressions", () => {
+      strictEqual(S.noCase("a_b-c", { stripRegExp: [/_/g, /-/g] }), "a b c")
+    })
+
     it("handles underscores and hyphens", () => {
       strictEqual(S.noCase("hello_world"), "hello world")
       strictEqual(S.noCase("hello-world"), "hello world")