diff --git a/config/babel/oxcJestTransformer.js b/config/babel/oxcJestTransformer.js
new file mode 100644
index 000000000000..33a1f167c35f
--- /dev/null
+++ b/config/babel/oxcJestTransformer.js
@@ -0,0 +1,93 @@
+const crypto = require('crypto');
+const fs = require('fs');
+const path = require('path');
+const esbuild = require('esbuild');
+const {transformSync} = require('oxc-transform-react');
+
+const babelJest = require('babel-jest');
+const OXC_TRANSFORM_REACT_VERSION = require('oxc-transform-react/package.json').version;
+const BaseReactCompilerConfig = require('./reactCompilerConfig');
+
+const babelTransformer = babelJest.createTransformer();
+
+const NODE_MODULES_RE = /[/\\]node_modules[/\\]/;
+const TESTS_RE = /[/\\]tests[/\\]/;
+const JEST_SETUP_RE = /[/\\]jest[/\\]/;
+const MOCKS_RE = /[/\\]__mocks__[/\\]/;
+
+const TRANSFORMER_SOURCE = fs.readFileSync(__filename);
+const REACT_COMPILER_CONFIG_KEY = JSON.stringify(BaseReactCompilerConfig);
+
+const REACT_COMPILER_OPTIONS = {
+    ...BaseReactCompilerConfig,
+    panicThreshold: 'none',
+    eslintSuppressionRules: [],
+};
+
+function getLang(filename) {
+    const ext = path.extname(filename).slice(1);
+    if (ext === 'tsx') {
+        return 'tsx';
+    }
+    if (ext === 'ts') {
+        return 'ts';
+    }
+    return 'jsx';
+}
+
+function shouldUseOxc(filename) {
+    return !NODE_MODULES_RE.test(filename) && !TESTS_RE.test(filename) && !JEST_SETUP_RE.test(filename) && !MOCKS_RE.test(filename);
+}
+
+function processWithOxc(sourceText, sourcePath) {
+    const oxcResult = transformSync(sourcePath, sourceText, {
+        lang: getLang(sourcePath),
+        sourcemap: true,
+        jsx: {runtime: 'automatic', development: true},
+        reactCompiler: REACT_COMPILER_OPTIONS,
+    });
+
+    if (oxcResult.fatal || !oxcResult.code) {
+        return null;
+    }
+
+    const cjs = esbuild.transformSync(oxcResult.code, {
+        loader: 'js',
+        format: 'cjs',
+        supported: {'dynamic-import': false},
+        sourcefile: sourcePath,
+        sourcemap: true,
+    });
+
+    return {code: cjs.code, map: cjs.map};
+}
+
+module.exports = {
+    canInstrument: false,
+    getCacheKey(sourceText, sourcePath, transformOptions) {
+        if (!shouldUseOxc(sourcePath)) {
+            return babelTransformer.getCacheKey(sourceText, sourcePath, transformOptions);
+        }
+
+        return crypto
+            .createHash('sha1')
+            .update(sourceText)
+            .update('\0', 'utf8')
+            .update(sourcePath)
+            .update(TRANSFORMER_SOURCE)
+            .update(REACT_COMPILER_CONFIG_KEY)
+            .update(esbuild.version)
+            .update(OXC_TRANSFORM_REACT_VERSION)
+            .digest('hex');
+    },
+    process(sourceText, sourcePath, transformOptions) {
+        if (shouldUseOxc(sourcePath)) {
+            const result = processWithOxc(sourceText, sourcePath);
+            if (result) {
+                return result;
+            }
+        }
+
+        return babelTransformer.process(sourceText, sourcePath, transformOptions);
+    },
+};
diff --git a/jest.config.js b/jest.config.js
index 7b9a523b566f..14b6e257de98 100644
--- a/jest.config.js
+++ b/jest.config.js
@@ -18,7 +18,10 @@ module.exports = {
         `<rootDir>/?(*.)+(spec|test).${testFileExtension}`,
     ],
     transform: {
-        '^.+\\.[jt]sx?$': 'babel-jest',
+        // Reassure re-transforms ~7k files under `--max-opt=1` (V8 sparkplug only), which
+        // makes Babel ~half of each measure job. OXC + esbuild is native and stays fast
+        // without TurboFan. Test files stay on babel-jest so `jest.mock` is still hoisted.
+        '^.+\\.[jt]sx?$': isPerfTestRun ? '<rootDir>/config/babel/oxcJestTransformer.js' : 'babel-jest',
         '^.+\\.svg?$': 'jest-transformer-svg',
     },
     transformIgnorePatterns: [
diff --git a/knip.json b/knip.json
index 5ba328041087..0096a0064917 100644
--- a/knip.json
+++ b/knip.json
@@ -15,6 +15,7 @@
                 "tests/globals.d.ts",
                 ".storybook/**/*.{js,ts,tsx}",
                 "metro.config.js",
+                "config/babel/oxcJestTransformer.js",
                 "eslint.changed.config.mjs",
                 "react-native.config.js",
                 "rock.config.mjs",
diff --git a/tests/tooling/oxcTransformer.test.ts b/tests/tooling/oxcTransformer.test.ts
new file mode 100644
index 000000000000..85d92cc27dbb
--- /dev/null
+++ b/tests/tooling/oxcTransformer.test.ts
@@ -0,0 +1,84 @@
+import {describe, expect, it} from 'bun:test';
+
+import {createRequire} from 'node:module';
+import path from 'node:path';
+
+type TransformResult = {code: string};
+
+type OxcTransformer = {
+    process: (sourceText: string, sourcePath: string, transformOptions: unknown) => TransformResult;
+};
+
+// eslint-disable-next-line @typescript-eslint/no-unsafe-type-assertion -- Jest transformers are CJS and tsconfig.bun.json does not type-check config/babel/
+const oxcTransformer = createRequire(import.meta.url)('../../config/babel/oxcJestTransformer') as OxcTransformer;
+
+const transformOptions = {
+    config: {cwd: process.cwd(), rootDir: process.cwd(), cache: false},
+    cacheFS: new Map(),
+    configString: '',
+    instrument: false,
+    supportsDynamicImport: false,
+    supportsExportNamespaceFrom: false,
+    supportsStaticESM: false,
+    supportsTopLevelAwait: false,
+};
+
+describe('oxcTransformer', () => {
+    it('emits CommonJS for app TypeScript', () => {
+        const source = `
+            export function add(a: number, b: number): number {
+                return a + b;
+            }
+        `;
+        const result = oxcTransformer.process(source, path.resolve('src/libs/math.ts'), transformOptions);
+        expect(result.code).toContain('module.exports');
+        expect(result.code).toContain('add: () => add');
+        expect(result.code).not.toMatch(/^export /m);
+        expect(result.code).not.toContain(': number');
+    });
+
+    it('runs React Compiler on app components', () => {
+        const source = `
+            export function Hello({name}: {name: string}) {
+                return <div>{name.toUpperCase()}</div>;
+            }
+        `;
+        const result = oxcTransformer.process(source, path.resolve('src/components/Hello.tsx'), transformOptions);
+        expect(result.code).toMatch(/compiler-runtime|_c\(/);
+        expect(result.code).toContain('jsxDEV');
+    });
+
+    it('leaves test files on babel-jest so jest.mock is hoisted', () => {
+        const source = `
+            import foo from './foo';
+            jest.mock('./foo');
+            export const x = 1;
+        `;
+        const result = oxcTransformer.process(source, path.resolve('tests/perf-test/Hello.perf-test.tsx'), transformOptions);
+        expect(result.code).toContain('_getJestObj().mock("./foo")');
+        expect(result.code.indexOf('_getJestObj().mock')).toBeLessThan(result.code.indexOf('exports.x'));
+    });
+
+    it('lowers dynamic import() so Jest still owns the module graph', () => {
+        const source = `
+            export function loadLazy() {
+                return import('./LazyScreen');
+            }
+        `;
+        const result = oxcTransformer.process(source, path.resolve('src/libs/loadLazy.ts'), transformOptions);
+        expect(result.code).not.toMatch(/\bimport\s*\(/);
+        expect(result.code).toMatch(/require\(['"]\.\/LazyScreen['"]\)/);
+    });
+
+    it('falls back to babel-jest for Flow in node_modules', () => {
+        const source = `
+            // @flow
+            export function add(a: number, b: number): number {
+                return a + b;
+            }
+        `;
+        const result = oxcTransformer.process(source, path.resolve('node_modules/react-native/Libraries/foo.js'), transformOptions);
+        expect(result.code).toBeTruthy();
+        expect(result.code).not.toContain(': number');
+    });
+});