MIF300.xsd

<?xml version="1.0" encoding="UTF-8"?>
<xs:schema xmlns="http://www.w3.org/2001/XMLSchema" xmlns:xs="http://www.w3.org/2001/XMLSchema"
           xmlns:mif="http://psi.hupo.org/mi/mif300"
           targetNamespace="http://psi.hupo.org/mi/mif300" elementFormDefault="qualified"
           attributeFormDefault="unqualified">
    <!--Root element-->
    <xs:element name="entrySet" type="mif:entrySet">
        <xs:annotation>
            <xs:documentation>Root element of the Molecular Interaction Format</xs:documentation>
        </xs:annotation>
    </xs:element>

    <xs:complexType name="entrySet">
        <xs:sequence>
            <xs:element name="entry" maxOccurs="unbounded" type="mif:entry">
                <xs:annotation>
                    <xs:documentation>Describes one or more interactions as a self-contained unit. Multiple entries from different files can be
                        concatenated into a single entrySet.</xs:documentation>
                </xs:annotation>
            </xs:element>
        </xs:sequence>
        <xs:attribute name="level" type="xs:int" use="required" fixed="3">
            <xs:annotation>
                <xs:documentation>PSI MI level</xs:documentation>
            </xs:annotation>
        </xs:attribute>
        <xs:attribute name="version" type="xs:int" use="required" fixed="0">
            <xs:annotation>
                <xs:documentation>PSI MI version within given level</xs:documentation>
            </xs:annotation>
        </xs:attribute>
        <xs:attribute name="minorVersion" type="xs:int" use="optional" fixed="0"/>
    </xs:complexType>

    <xs:complexType name="source">
        <xs:annotation>
            <xs:documentation>Desciption of the source of the entry, usually an organisation
            </xs:documentation>
        </xs:annotation>
        <xs:sequence>
            <xs:element name="names" type="mif:names" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>Name(s) of the data source, for example the organisation name.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="bibref" type="mif:bibref" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>Bibliographic reference for the data source. Example: A paper which
                        describes all interactions of the entry.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="xref" type="mif:xref" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>Cross reference for the data source. Example: Entry in a database of
                        databases.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="attributeList" type="mif:attributeList" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>Further description of the source.</xs:documentation>
                </xs:annotation>
            </xs:element>
        </xs:sequence>
        <xs:attribute name="release" use="optional">
            <xs:simpleType>
                <xs:restriction base="xs:string">
                    <xs:minLength value="1"/>
                </xs:restriction>
            </xs:simpleType>
        </xs:attribute>
        <xs:attribute name="releaseDate" type="xs:date" use="optional"/>
    </xs:complexType>

    <xs:complexType name="experimentDescriptionList">
        <xs:annotation>
            <xs:documentation>All experiments in which the interactions of this entry have been determined
            </xs:documentation>
        </xs:annotation>
        <xs:sequence>
            <xs:element name="experimentDescription" type="mif:experimentDescription" minOccurs="0"
                        maxOccurs="unbounded">
                <xs:annotation>
                    <xs:documentation>Describes one set of experimental parameters, usually associated with
                        a single publication.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
        </xs:sequence>
    </xs:complexType>

    <xs:complexType name="experimentList">
        <xs:annotation>
            <xs:documentation>List of experiments in which this interaction has been determined.</xs:documentation>
        </xs:annotation>

        <xs:choice maxOccurs="unbounded">
            <xs:annotation>
                <xs:documentation>Either refer to an already defined experiment in this entry or insert description.
                </xs:documentation>
            </xs:annotation>
            <xs:element name="experimentRef" type="xs:int">
                <xs:annotation>
                    <xs:documentation>References an experiment already present in this entry.</xs:documentation>
                </xs:annotation>

            </xs:element>
            <xs:element name="experimentDescription" type="mif:experimentDescription">
                <xs:annotation>
                    <xs:documentation>An experiment in which this interaction has been determined.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
        </xs:choice>
    </xs:complexType>

    <xs:complexType name="interactorList">
        <xs:annotation>
            <xs:documentation>List of all interactors occurring in the entry</xs:documentation>
        </xs:annotation>
        <xs:sequence>
            <xs:element name="interactor" type="mif:interactor" minOccurs="1" maxOccurs="unbounded">
                <xs:annotation>
                    <xs:documentation>A molecule object in its native state, as described in databases.
                    </xs:documentation>
                    <xs:documentation>Usage: A protein interactor must contain an xref to UniProt and
                        NCBI-GI where possible.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
        </xs:sequence>
    </xs:complexType>

    <xs:complexType name="interactionList">
        <xs:annotation>
            <xs:documentation>List of interactions</xs:documentation>
        </xs:annotation>
        <xs:sequence>
            <xs:choice maxOccurs="unbounded">
                <xs:element name="interaction" type="mif:interaction"/>
                <xs:element name="abstractInteraction" type="mif:abstractInteraction">
                    <xs:annotation>
                        <xs:documentation>Abstract interaction describing a stable complex, allosteric interaction , etc...
                            These interactions are abstracted from the experimental context and used to describe biological entities
                        </xs:documentation>
                    </xs:annotation>
                </xs:element>
            </xs:choice>
        </xs:sequence>
    </xs:complexType>

    <xs:complexType name="availabilityList">
        <xs:annotation>
            <xs:documentation>Data availability statements, for example copyrights</xs:documentation>
        </xs:annotation>
        <xs:sequence>
            <xs:element name="availability" type="mif:availability" minOccurs="0" maxOccurs="unbounded">
                <xs:annotation>
                    <xs:documentation>Describes data availability, e.g. through a copyright statement. If no
                        availability is given, the data is assumed to be freely available.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
        </xs:sequence>
    </xs:complexType>


    <!-- entry -->

    <xs:complexType name="entry">
        <xs:sequence>
            <xs:element name="source" type="mif:source" minOccurs="0"/>
            <xs:element name="availabilityList" type="mif:availabilityList" minOccurs="0"/>
            <xs:element name="experimentList" type="mif:experimentDescriptionList" minOccurs="0"/>
            <xs:element name="interactorList" type="mif:interactorList" minOccurs="0"/>

            <xs:element name="interactionList" type="mif:interactionList"/>
            <xs:element name="attributeList" type="mif:attributeList" minOccurs="0"/>
        </xs:sequence>
    </xs:complexType>

    <!--aministrative elements-->
    <xs:complexType name="label">
        <xs:annotation>
            <xs:documentation>A short alphanumeric label identifying an object. Not necessarily unique.</xs:documentation>
        </xs:annotation>
        <xs:simpleContent>
            <xs:extension base="xs:string"/>
        </xs:simpleContent>
    </xs:complexType>
    <xs:complexType name="fullName">
        <xs:annotation>
            <xs:documentation>Full, descriptive object name.</xs:documentation>
        </xs:annotation>
        <xs:simpleContent>
            <xs:extension base="xs:string"/>
        </xs:simpleContent>
    </xs:complexType>
    <xs:complexType name="experimentRefList">
        <xs:annotation>
            <xs:documentation>Refers to a list of experiments within the same entry.</xs:documentation>
        </xs:annotation>
        <xs:sequence>
            <xs:element name="experimentRef" type="xs:int" maxOccurs="unbounded">
                <xs:annotation>
                    <xs:documentation>References an experiment already present in this entry.</xs:documentation>
                </xs:annotation>
            </xs:element>
        </xs:sequence>
    </xs:complexType>
    <xs:complexType name="xref">
        <xs:annotation>
            <xs:documentation>Crossreference to an external database. Crossreferences to literature databases, e.g. PubMed, should not be put into
                this structure, but into the bibRef element where possible.</xs:documentation>
        </xs:annotation>
        <xs:sequence>
            <xs:element name="primaryRef" type="mif:dbReference">
                <xs:annotation>
                    <xs:documentation>Primary reference to an external database.</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="secondaryRef" type="mif:dbReference" minOccurs="0" maxOccurs="unbounded">
                <xs:annotation>
                    <xs:documentation>Further external objects describing the object.</xs:documentation>
                </xs:annotation>
            </xs:element>
        </xs:sequence>
    </xs:complexType>
    <xs:complexType name="dbReference">
        <xs:annotation>
            <xs:documentation>Refers to a unique object in an external database.</xs:documentation>
        </xs:annotation>
        <xs:sequence minOccurs="0">
            <xs:element name="attributeList" type="mif:attributeList"/>
        </xs:sequence>
        <xs:attribute name="db" use="required">
            <xs:annotation>
                <xs:documentation>Name of the external database. Taken from the controlled vocabulary of databases.</xs:documentation>
            </xs:annotation>
            <xs:simpleType>
                <xs:restriction base="xs:string">
                    <xs:minLength value="1"/>
                </xs:restriction>
            </xs:simpleType>
        </xs:attribute>
        <xs:attribute name="dbAc" use="optional">
            <xs:annotation>
                <xs:documentation>Accession number of the database in the database CV. This element is controlled by the PSI-MI controlled
                    vocabulary "database citation", root term id MI:0444.</xs:documentation>
            </xs:annotation>
            <xs:simpleType>
                <xs:restriction base="xs:string">
                    <xs:minLength value="1"/>
                </xs:restriction>
            </xs:simpleType>
        </xs:attribute>
        <xs:attribute name="id" use="required">
            <xs:annotation>
                <xs:documentation>Primary identifier of the object in the external database, e.g. UniProt accession number.</xs:documentation>
            </xs:annotation>
            <xs:simpleType>
                <xs:restriction base="xs:string">
                    <xs:minLength value="1"/>
                </xs:restriction>
            </xs:simpleType>
        </xs:attribute>
        <xs:attribute name="secondary" use="optional">
            <xs:annotation>
                <xs:documentation>Secondary identifier of the object in the external database, e.g. UniProt ID.</xs:documentation>
            </xs:annotation>
            <xs:simpleType>
                <xs:restriction base="xs:string">
                    <xs:minLength value="1"/>
                </xs:restriction>
            </xs:simpleType>
        </xs:attribute>
        <xs:attribute name="version" use="optional">
            <xs:annotation>
                <xs:documentation>The version number of the object in the external database.</xs:documentation>
            </xs:annotation>
            <xs:simpleType>
                <xs:restriction base="xs:string">
                    <xs:minLength value="1"/>
                </xs:restriction>
            </xs:simpleType>
        </xs:attribute>
        <xs:attribute name="refType" use="optional">
            <xs:annotation>
                <xs:documentation>Reference type, e.g. "identity" if this reference referes to an identical object in the external database,
                    or "see-also" for additional information. Controlled by CV.</xs:documentation>
            </xs:annotation>
            <xs:simpleType>
                <xs:restriction base="xs:string">
                    <xs:minLength value="1"/>
                </xs:restriction>
            </xs:simpleType>
        </xs:attribute>
        <xs:attribute name="refTypeAc" use="optional">
            <xs:annotation>
                <xs:documentation>Reference type accession number from the CV of reference types. This element is controlled by the PSI-MI
                    controlled vocabulary "xref type", root term id MI:0353. </xs:documentation>
            </xs:annotation>
            <xs:simpleType>
                <xs:restriction base="xs:string">
                    <xs:minLength value="1"/>
                </xs:restriction>
            </xs:simpleType>
        </xs:attribute>
    </xs:complexType>
    <xs:complexType name="bibref">
        <xs:annotation>
            <xs:documentation>Bibliographic reference.</xs:documentation>
        </xs:annotation>
        <xs:choice minOccurs="1" maxOccurs="1">
            <xs:sequence>
                <xs:element name="xref" type="mif:xref" minOccurs="1" maxOccurs="1">
                    <xs:annotation>
                        <xs:documentation>Bibliographic reference in external database, usually PubMed.</xs:documentation>
                    </xs:annotation>
                </xs:element>
                <xs:element name="attributeList" type="mif:attributeList" minOccurs="0" maxOccurs="1">
                    <xs:annotation>
                        <xs:documentation>Additional description of bibliographic reference such as publication title, authors, journal,
                            publication date...</xs:documentation>
                    </xs:annotation>
                </xs:element>
            </xs:sequence>
            <xs:sequence>
                <xs:element name="attributeList" type="mif:attributeList" minOccurs="1" maxOccurs="1">
                    <xs:annotation>
                        <xs:documentation>Alternative description of bibliographic reference if no external database entry is available.</xs:documentation>
                    </xs:annotation>
                </xs:element>
            </xs:sequence>
        </xs:choice>
    </xs:complexType>
    <xs:complexType name="attributeList">
        <xs:annotation>
            <xs:documentation>A list of additional attributes. Open tag-value list to allow the inclusion of additional data.</xs:documentation>
        </xs:annotation>
        <xs:sequence>
            <xs:element name="attribute" type="mif:attribute" maxOccurs="unbounded"/>
        </xs:sequence>
    </xs:complexType>
    <xs:complexType name="attribute">
        <xs:simpleContent>
            <xs:extension base="xs:string">
                <xs:attribute name="name" use="required">
                    <xs:annotation>
                        <xs:documentation>The name of the attribute.</xs:documentation>
                    </xs:annotation>
                    <xs:simpleType>
                        <xs:restriction base="xs:string">
                            <xs:minLength value="1"/>
                        </xs:restriction>
                    </xs:simpleType>
                </xs:attribute>
                <xs:attribute name="nameAc" use="optional">
                    <xs:annotation>
                        <xs:documentation>Enables control of the attribute type through reference to an external
                            controlled vocabulary. Root element in the PSI MI CV is MI:0590.
                        </xs:documentation>
                    </xs:annotation>
                    <xs:simpleType>
                        <xs:restriction base="xs:string">
                            <xs:minLength value="1"/>
                        </xs:restriction>
                    </xs:simpleType>
                </xs:attribute>
            </xs:extension>
        </xs:simpleContent>
    </xs:complexType>
    <xs:complexType name="confidenceBase">
        <xs:annotation>
            <xs:documentation>A confidence value.</xs:documentation>
        </xs:annotation>
        <xs:sequence>
            <xs:element name="unit" type="mif:openCvType"/>
            <xs:element name="value">
                <xs:simpleType>
                    <xs:restriction base="xs:string">
                        <xs:minLength value="1"/>
                    </xs:restriction>
                </xs:simpleType>
            </xs:element>
        </xs:sequence>
    </xs:complexType>
    <xs:complexType name="confidence">
        <xs:complexContent>
            <xs:extension base="mif:confidenceBase">
                <xs:sequence minOccurs="0">
                    <xs:element name="experimentRefList" type="mif:experimentRefList" minOccurs="0">
                        <xs:annotation>
                            <xs:documentation>Each experiment might assign a different confidence to this object. If no
                                experimentRef is given, it is assumed this confidence refers to all experiments linked
                                to the object.
                            </xs:documentation>
                        </xs:annotation>
                    </xs:element>
                </xs:sequence>
            </xs:extension>
        </xs:complexContent>
    </xs:complexType>
    <xs:complexType name="bioSource">
        <xs:annotation>
            <xs:documentation>Describes the biological source of an object, in simple form only the NCBI taxid.</xs:documentation>
        </xs:annotation>
        <xs:sequence>
            <xs:element name="names" type="mif:names" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>The names of the organism.  The short label should be a common name if it exists.  The full name should be
                        the full name of the species (i.e. genus species).</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="cellType" type="mif:openCvType" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>Description of the cell type. Currently no species-independent controlled vocabulary for cell types is available,
                        therefore the choice of reference database(s) is open to the data provider.</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="compartment" type="mif:openCvType" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>The subcellular compartment of the object. It is strongly recommended to refer to the Gene Ontology cellular
                        component in this element.</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="tissue" type="mif:openCvType" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>Description of the source tissue. Currently no species-independent controlled vocabulary for tissues is available,
                        therefore the choice of reference database(s) is open to the data provider.</xs:documentation>
                </xs:annotation>
            </xs:element>
        </xs:sequence>
        <xs:attribute name="ncbiTaxId" type="xs:int" use="required"/>
    </xs:complexType>
    <xs:complexType name="abstractConfidenceList">
        <xs:annotation>
            <xs:documentation>A list of confidence values for a complex or abstract interaction.
                These confidences can refer to their original publications.</xs:documentation>
        </xs:annotation>
        <xs:sequence>
            <xs:element name="confidence" type="mif:abstractConfidence" maxOccurs="unbounded"/>
        </xs:sequence>
    </xs:complexType>
    <xs:complexType name="abstractConfidence">
        <xs:annotation>
            <xs:documentation>A confidence value for a complex or other 'abstract' interaction.
                It can refer to its original publication/review.</xs:documentation>
        </xs:annotation>
        <xs:sequence>
            <xs:element name="type" type="mif:openCvType"/>
            <xs:element name="value">
                <xs:simpleType>
                    <xs:restriction base="xs:string">
                        <xs:minLength value="1"/>
                    </xs:restriction>
                </xs:simpleType>
            </xs:element>
            <xs:element name="bibref" type="mif:bibref" minOccurs="0"/>
        </xs:sequence>
    </xs:complexType>

    <xs:complexType name="confidenceList">
        <xs:annotation>
            <xs:documentation>A list of confidence values.</xs:documentation>
        </xs:annotation>
        <xs:sequence>
            <xs:element name="confidence" type="mif:confidence" maxOccurs="unbounded"/>
        </xs:sequence>
    </xs:complexType>
    <xs:complexType name="cvType">
        <xs:annotation>
            <xs:documentation>Reference to an external controlled vocabulary.</xs:documentation>
        </xs:annotation>
        <xs:sequence>
            <xs:element name="names" type="mif:names">
                <xs:annotation>
                    <xs:documentation>Name of the controlled vocabulary term.</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="xref" type="mif:xref">
                <xs:annotation>
                    <xs:documentation>Source of the controlled vocabulary term.  E.g. the name of the CV and the term ID.</xs:documentation>
                </xs:annotation>
            </xs:element>
        </xs:sequence>
    </xs:complexType>
    <xs:complexType name="openCvType">
        <xs:annotation>
            <xs:documentation>Allows to reference an external controlled vocabulary, or to directly include a value if no suitable external definition
                is available.</xs:documentation>
        </xs:annotation>
        <xs:sequence>
            <xs:element name="names" type="mif:names">
                <xs:annotation>
                    <xs:documentation>This contains the controlled vocabulary terms, as a short and optionally as a long form.</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="xref" type="mif:xref" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>Refers to the term of the controlled vocabulary in an external database.</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="attributeList" type="mif:attributeList" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>If no suitable external controlled vocabulary is available, this attributeList can be used to describe the term.
                        Example: Attribute name: Mouse atlas tissue name; attribute value: spinal cord, day 30.</xs:documentation>
                </xs:annotation>
            </xs:element>
        </xs:sequence>
    </xs:complexType>
    <xs:complexType name="names">
        <xs:annotation>
            <xs:documentation>Names for an object.</xs:documentation>
        </xs:annotation>
        <xs:sequence>
            <xs:element name="shortLabel" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>A short string, suitable to remember the object. Can be e.g. a gene name, the first author of a paper, etc.</xs:documentation>
                </xs:annotation>
                <xs:simpleType>
                    <xs:restriction base="xs:string">
                        <xs:minLength value="1"/>
                    </xs:restriction>
                </xs:simpleType>
            </xs:element>
            <xs:element name="fullName" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>A full, detailed name or description of the object. Can be e.g. the full title of a publication, or the
                        scientific name of a species.</xs:documentation>
                </xs:annotation>
                <xs:simpleType>
                    <xs:restriction base="xs:string">
                        <xs:minLength value="1"/>
                    </xs:restriction>
                </xs:simpleType>
            </xs:element>
            <xs:element name="alias" type="mif:alias" minOccurs="0" maxOccurs="unbounded"/>
        </xs:sequence>
    </xs:complexType>

    <xs:complexType name="alias">
        <xs:simpleContent>
            <xs:extension base="xs:string">
                <xs:attribute name="typeAc" use="optional">
                    <xs:simpleType>
                        <xs:restriction base="xs:string">
                            <xs:minLength value="1"/>
                        </xs:restriction>
                    </xs:simpleType>
                </xs:attribute>
                <xs:attribute name="type" use="optional">
                    <xs:simpleType>
                        <xs:restriction base="xs:string">
                            <xs:minLength value="1"/>
                        </xs:restriction>
                    </xs:simpleType>
                </xs:attribute>
            </xs:extension>
        </xs:simpleContent>
    </xs:complexType>

    <xs:complexType name="parameterBase">
        <xs:annotation>
            <xs:documentation>A numeric parameter, e.g. for a kinetic value</xs:documentation>
        </xs:annotation>
        <xs:attribute name="term" use="required">
            <xs:annotation>
                <xs:documentation>The kind of parameter, e.g. "dissociation constant".</xs:documentation>
            </xs:annotation>
            <xs:simpleType>
                <xs:restriction base="xs:string">
                    <xs:minLength value="1"/>
                </xs:restriction>
            </xs:simpleType>
        </xs:attribute>
        <xs:attribute name="termAc" use="optional">
            <xs:annotation>
                <xs:documentation>Accession number of the term in the associated controlled vocabulary.</xs:documentation>
            </xs:annotation>
            <xs:simpleType>
                <xs:restriction base="xs:string">
                    <xs:minLength value="1"/>
                </xs:restriction>
            </xs:simpleType>
        </xs:attribute>
        <xs:attribute name="unit" use="optional">
            <xs:annotation>
                <xs:documentation>The unit of the term, e.g. "kiloDalton".</xs:documentation>
            </xs:annotation>
            <xs:simpleType>
                <xs:restriction base="xs:string">
                    <xs:minLength value="1"/>
                </xs:restriction>
            </xs:simpleType>
        </xs:attribute>
        <xs:attribute name="unitAc" use="optional">
            <xs:annotation>
                <xs:documentation>Accession number of the unit in the associated controlled vocabulary.</xs:documentation>
            </xs:annotation>
            <xs:simpleType>
                <xs:restriction base="xs:string">
                    <xs:minLength value="1"/>
                </xs:restriction>
            </xs:simpleType>
        </xs:attribute>
        <xs:attribute name="base" type="xs:short" use="optional" default="10">
            <xs:annotation>
                <xs:documentation>Base of the parameter expression. Defaults to 10.</xs:documentation>
            </xs:annotation>
        </xs:attribute>
        <xs:attribute name="exponent" type="xs:short" use="optional" default="0">
            <xs:annotation>
                <xs:documentation>Exponent of the value.</xs:documentation>
            </xs:annotation>
        </xs:attribute>
        <xs:attribute name="factor" type="xs:decimal" use="required">
            <xs:annotation>
                <xs:documentation>The "main" value of the parameter.</xs:documentation>
            </xs:annotation>
        </xs:attribute>
    </xs:complexType>
    <!--Feature description-->
    <xs:complexType name="feature">
        <xs:annotation>
            <xs:documentation>A feature, e.g. domain, on a sequence.</xs:documentation>
        </xs:annotation>
        <xs:sequence>
            <xs:element name="names" type="mif:names" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>Names for the feature, e.g. SH3 domain.</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="xref" type="mif:xref" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>Reference to an external feature description, for example InterPro entry.</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="featureType" type="mif:cvType" maxOccurs="1" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>Description and classification of the feature. This element is controlled by the PSI-MI controlled vocabulary
                        "feature",
                        root term id MI:0116.</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="featureDetectionMethod" type="mif:cvType" maxOccurs="unbounded" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>Experimental method used to identify the feature. A setting here overrides the global setting given in the
                        experimentDescription.
                        External controlled vocabulary. </xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="experimentRefList" type="mif:experimentRefList" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>If no experimentRef is given, it is assumed this refers to all experiments linked to the interaction.</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="featureRangeList">
                <xs:complexType>
                    <xs:sequence>
                        <xs:element name="featureRange" type="mif:baseLocation" maxOccurs="unbounded">
                            <xs:annotation>
                                <xs:documentation>Location of the feature on the sequence of the interactor. One feature may have more than one
                                    featureRange, used e.g. for features which involve sequence positions close in the folded, three-dimensional
                                    state of a protein, but non-continuous along the sequence.</xs:documentation>
                            </xs:annotation>
                        </xs:element>
                    </xs:sequence>
                </xs:complexType>
            </xs:element>
            <xs:element name="featureRole" type="mif:cvType" minOccurs="0" maxOccurs="1">
                <xs:annotation>
                    <xs:documentation>The role of the feature in the context of this interaction. It usually describes the impact of
                        the interaction on the feature. (Ex: resulting-ptm, ...) or the impact of the feature on the interaction.
                        (Ex: prerequisite-ptm,...).</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="parameterList" type="mif:parameterList" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>List of experimental parameters attached to this feature. For instance,
                        the changes in the kd of the interaction will be added at the feature level with the description of the mutation</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="attributeList" type="mif:attributeList" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>Semi-structured additional description of the data contained in the entry.</xs:documentation>
                </xs:annotation>
            </xs:element>
        </xs:sequence>
        <xs:attribute name="id" type="xs:int" use="required"/>
    </xs:complexType>
    <xs:complexType name="interval">
        <xs:annotation>
            <xs:documentation>A interval on a sequence.</xs:documentation>
        </xs:annotation>
        <xs:attribute name="begin" type="xs:long" use="required"/>
        <xs:attribute name="end" type="xs:long" use="required"/>
    </xs:complexType>
    <xs:complexType name="baseLocation">
        <xs:annotation>
            <xs:documentation>A location on a sequence. Both begin and end can be a defined position, a fuzzy position, or undetermined.</xs:documentation>
        </xs:annotation>
        <xs:sequence>
            <xs:sequence>
                <xs:element name="startStatus" type="mif:cvType">
                    <xs:annotation>
                        <xs:documentation>Attribute of the start positions, e.g. "certain" or "n-terminal"</xs:documentation>
                    </xs:annotation>
                </xs:element>
                <xs:choice minOccurs="0">
                    <xs:element name="begin" type="mif:position">
                        <xs:annotation>
                            <xs:documentation>The integer position gives the begin position of the feature. The first base or amino acid is position 1.
                                In combination with the numeric value, the attribute 'status' allows to express fuzzy positions, e.g. 'less than 4'.
                                Negative positions can be used to describe promoter regions when the interactor is a gene but should not be allowed for
                                proteins</xs:documentation>
                        </xs:annotation>
                    </xs:element>
                    <xs:element name="beginInterval" type="mif:interval">
                        <xs:annotation>
                            <xs:documentation>The begin position may be varying or unclear, but localisable to a certain range. Usually written as e.g.
                                3..5.
                                Negative positions can be used to describe promoter regions when the interactor is a gene but should not be allowed for
                                proteins</xs:documentation>
                        </xs:annotation>
                    </xs:element>
                </xs:choice>
            </xs:sequence>
            <xs:sequence>
                <xs:element name="endStatus" type="mif:cvType">
                    <xs:annotation>
                        <xs:documentation>Attribute of the end positions, e.g. "certain" or "c-terminal"</xs:documentation>
                    </xs:annotation>
                </xs:element>
                <xs:choice minOccurs="0">
                    <xs:element name="end" type="mif:position">
                        <xs:annotation>
                            <xs:documentation>The integer position gives the end position of the feature. The first base or amino acid is position 1.
                                In combination with the numeric value, the attribute 'status' allows to express fuzzy positions, e.g. 'more than 400'.
                                Negative positions can be used to describe promoter regions when the interactor is a gene but should not be allowed for
                                proteins</xs:documentation>
                        </xs:annotation>
                    </xs:element>
                    <xs:element name="endInterval" type="mif:interval">
                        <xs:annotation>
                            <xs:documentation>The end position may be varying or unclear, but localisable to a certain range. Usually written as e.g.
                                3..5.
                                Negative positions can be used to describe promoter regions when the interactor is a gene but should not be allowed for
                                proteins</xs:documentation>
                        </xs:annotation>
                    </xs:element>
                </xs:choice>
            </xs:sequence>
            <xs:element name="isLink" type="xs:boolean" default="false" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>True if the described feature is a linking feature connecting two amino acids rather than extending along the
                        sequence. 'begin' references the first amino acid, 'end' the second. Standard example is a disulfide bridge. Does not
                        reference another feature, therefore is only suitable for linking features on the same amino acid chain. </xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="resultingSequence" type="mif:resultingSequenceType" minOccurs="0" maxOccurs="1">
                <xs:annotation>
                    <xs:documentation>The resultingSequence gives some information about the sequence changes.</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="participantRef" type="xs:int" minOccurs="0" maxOccurs="1">
                <xs:annotation>
                    <xs:documentation>References a participant described in the entry. The participantRef is aimed at describing complex binding sites
                        such as composite binding sites where the participant is an interaction and the binding site ranges has to specify which
                        participant in the subunit it refers to.</xs:documentation>
                </xs:annotation>
            </xs:element>
        </xs:sequence>
    </xs:complexType>
    <xs:complexType name="resultingSequenceType">
        <xs:annotation>
            <xs:documentation>Description of the mutated or transformed interactor sequence portion</xs:documentation>
        </xs:annotation>
        <xs:choice minOccurs="1" maxOccurs="1">
            <xs:sequence>
                <xs:sequence>
                    <xs:element name="originalSequence" minOccurs="1" maxOccurs="1">
                        <xs:annotation>
                            <xs:documentation>The original sequence portion.</xs:documentation>
                        </xs:annotation>
                    </xs:element>
                    <xs:element name="newSequence" minOccurs="1" maxOccurs="1">
                        <xs:annotation>
                            <xs:documentation>The mutated or transformed sequence portion.</xs:documentation>
                        </xs:annotation>
                    </xs:element>
                    <xs:element name="xref" type="mif:xref" minOccurs="0">
                        <xs:annotation>
                            <xs:documentation>External cross reference to a genetic variation database such as dbSNP.</xs:documentation>
                        </xs:annotation>
                    </xs:element>
                </xs:sequence>
            </xs:sequence>
            <xs:sequence>
                <xs:element name="xref" type="mif:xref" minOccurs="1" maxOccurs="1">
                    <xs:annotation>
                        <xs:documentation>External cross reference to a genetic variation database such as dbSNP.</xs:documentation>
                    </xs:annotation>
                </xs:element>
            </xs:sequence>
        </xs:choice>
    </xs:complexType>
    <xs:complexType name="position">
        <xs:attribute name="position" type="xs:long" use="required"/>
    </xs:complexType>
    <!--Top level types-->
    <xs:complexType name="availability">
        <xs:annotation>
            <xs:documentation>A text describing the availability of data, e.g. a copyright statement.</xs:documentation>
        </xs:annotation>
        <xs:simpleContent>
            <xs:extension base="xs:string">
                <xs:attribute name="id" type="xs:int" use="required"/>
            </xs:extension>
        </xs:simpleContent>
    </xs:complexType>

    <xs:complexType name="hostOrganismList">
        <xs:annotation>
            <xs:documentation>The host organism(s) in which the experiment has been performed.</xs:documentation>
        </xs:annotation>
        <xs:sequence>
            <xs:element name="hostOrganism" type="mif:hostOrganism" maxOccurs="unbounded"/>
        </xs:sequence>
    </xs:complexType>

    <xs:complexType name="hostOrganism">
        <xs:complexContent>
            <xs:extension base="mif:bioSource">
                <xs:sequence minOccurs="0">
                    <xs:element name="experimentRefList" type="mif:experimentRefList" minOccurs="0"/>
                </xs:sequence>
            </xs:extension>
        </xs:complexContent>
    </xs:complexType>

    <xs:complexType name="experimentDescription">
        <xs:annotation>
            <xs:documentation>Describes one set of experimental parameters.</xs:documentation>
        </xs:annotation>
        <xs:sequence>
            <xs:element name="names" type="mif:names" minOccurs="0"/>
            <xs:element name="bibref" type="mif:bibref">
                <xs:annotation>
                    <xs:documentation>Publication describing the experiment.</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="xref" type="mif:xref" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>Refers to external database description of the experiment.</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="hostOrganismList" type="mif:hostOrganismList" minOccurs="0"/>
            <xs:element name="interactionDetectionMethod" type="mif:cvType">
                <xs:annotation>
                    <xs:documentation>Experimental method to determine the interaction. This element is controlled by the PSI-MI controlled vocabulary
                        "interaction detection method", root term id MI:0001.</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="participantIdentificationMethod" type="mif:cvType" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>Experimental method to determine the interactors involved in the interaction. This element is controlled by the
                        PSI-MI controlled vocabulary "participant identification method", root term id MI:0002.</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="featureDetectionMethod" type="mif:cvType" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>Experimental method to determine the features of interactors. If this element is filled it is assumed to apply to
                        all features described in the experiment. But can be overridden by the featureDetectionMethod given in the individual feature.
                        This element is controlled by the PSI-MI controlled vocabulary "feature detection method", root term id MI:0003.</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="confidenceList" type="mif:confidenceList" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>Confidence in this experiment.  Usually a statistical measure.</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="variableParameterList" type="mif:variableParameterList" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>A list of variable parameters used in this experiment - eg - variable concentration of a specific drug.</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="attributeList" type="mif:attributeList" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>Semi-structured additional description of the experiment.</xs:documentation>
                </xs:annotation>
            </xs:element>
        </xs:sequence>
        <xs:attribute name="id" type="xs:int" use="required">
            <xs:annotation>
                <xs:documentation>All major objects have a numerical id which must be unique to that object within an entry. The object may be repeated,
                    though, e.g. in the denormalised representation.</xs:documentation>
            </xs:annotation>
        </xs:attribute>
    </xs:complexType>
    <xs:complexType name="variableParameterList">
        <xs:annotation>
            <xs:documentation>A list of variable parameters used in this experiment - eg - variable concentration of a specific drug.</xs:documentation>
        </xs:annotation>
        <xs:sequence>
            <xs:element name="variableParameter" type="mif:variableParameter" maxOccurs="unbounded"/>
        </xs:sequence>
    </xs:complexType>
    <xs:complexType name="variableParameter">
        <xs:annotation>
            <xs:documentation>Describes one variable parameter and its values in this experiment  - eg - variable concentration of a specific drug.</xs:documentation>
        </xs:annotation>
        <xs:sequence>
            <xs:element name="description" type="xs:string">
                <xs:annotation>
                    <xs:documentation>Free description of the variable parameter (such as cell cycle, PMA treatment, ...).</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="unit" type="mif:openCvType" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>Unit of the variable parameter values.</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="variableValueList" type="mif:variableValueList">
                <xs:annotation>
                    <xs:documentation>List of the different values for this specific variableParameter in this experiment.</xs:documentation>
                </xs:annotation>
            </xs:element>
        </xs:sequence>
    </xs:complexType>
    <xs:complexType name="variableValueList">
        <xs:annotation>
            <xs:documentation>List of the different values for a specific variableParameter in a specific experiment.</xs:documentation>
        </xs:annotation>
        <xs:sequence>
            <xs:element name="variableValue" type="mif:variableValue" maxOccurs="unbounded"/>
        </xs:sequence>
    </xs:complexType>
    <xs:complexType name="variableValue">
        <xs:annotation>
            <xs:documentation>A value for a specific variableParameter in a specific experiment - eg - the concentration of a specific drug.</xs:documentation>
        </xs:annotation>
        <xs:sequence>
            <xs:element name="value" type="xs:string">
                <xs:annotation>
                    <xs:documentation>Free description of the variable value. It can be numerical value or qualitative value depending on the
                        variableParameter.</xs:documentation>
                </xs:annotation>
            </xs:element>
        </xs:sequence>
        <xs:attribute name="id" type="xs:int" use="required">
            <xs:annotation>
                <xs:documentation>Unique numerical identifier for this variableValue so an interaction can refer to it later. The id has to be unique
                    within a same entry.</xs:documentation>
            </xs:annotation>
        </xs:attribute>
        <xs:attribute name="order" type="xs:int" use="optional">
            <xs:annotation>
                <xs:documentation>Optional numerical order attribute to give an explicit order for a variableValue in the variableValueList.</xs:documentation>
            </xs:annotation>
        </xs:attribute>
    </xs:complexType>
    <xs:complexType name="experimentalVariableValueList">
        <xs:annotation>
            <xs:documentation>A list of experimental parameter/condition values for which the interaction occurs.</xs:documentation>
        </xs:annotation>
        <xs:sequence>
            <xs:element name="experimentalVariableValues" minOccurs="1" maxOccurs="unbounded" type="mif:experimentalVariableValues">
                <xs:annotation>
                    <xs:documentation>A set of experimental parameter/conditions values applied together and for which this interaction occurs.</xs:documentation>
                </xs:annotation>
            </xs:element>
        </xs:sequence>
    </xs:complexType>
    <xs:complexType name="experimentalVariableValues">
        <xs:annotation>
            <xs:documentation>A set of experimental parameter/conditions values applied together and for which this interaction occurs.</xs:documentation>
        </xs:annotation>
        <xs:sequence>
            <xs:element name="variableValueRef" minOccurs="1" maxOccurs="unbounded" type="xs:int">
                <xs:annotation>
                    <xs:documentation>The reference to the id of the variableValue described in the
                        variableParameterList/variableParameter/variableParameterValueList
                        of the experiment.</xs:documentation>
                </xs:annotation>
            </xs:element>
        </xs:sequence>
    </xs:complexType>

    <xs:complexType name="interaction">
        <xs:annotation>
            <xs:documentation>A molecular interaction described with some experimental context.</xs:documentation>
        </xs:annotation>
        <xs:sequence>
            <xs:element name="names" type="mif:names" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>Name(s) of the interaction.</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="xref" type="mif:xref" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>Interaction database ID</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:choice minOccurs="0">
                <xs:annotation>
                    <xs:documentation>Either refer to an already defined availability statement in this entry or insert description.</xs:documentation>
                </xs:annotation>
                <xs:element name="availabilityRef" type="xs:int">
                    <xs:annotation>
                        <xs:documentation>References an availability statement already present in this entry.</xs:documentation>
                    </xs:annotation>
                </xs:element>
                <xs:element name="availability" type="mif:availability">
                    <xs:annotation>
                        <xs:documentation>Describes the availability of the interaction data. If no availability is given, the data is assumed to be
                            freely available.</xs:documentation>
                    </xs:annotation>
                </xs:element>
            </xs:choice>
            <xs:element name="experimentList" type="mif:experimentList"/>
            <xs:element name="participantList" type="mif:participantList"/>
            <xs:element name="inferredInteractionList" type="mif:inferredInteractionList" minOccurs="0"/>
            <xs:element name="interactionType" type="mif:cvType" minOccurs="0" maxOccurs="unbounded">
                <xs:annotation>
                    <xs:documentation>External controlled vocabulary characterising the interaction type, for example "physical interaction".</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="modelled" type="xs:boolean" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>If true, this element describes an interaction in a species of interest, e.g. human, but has actually been
                        investigated in another organism, e.g. mouse. The transfer will usually be based on a homology statement made by the data
                        producer. If this optional element is missing, it is assumed to be set to false.</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="intraMolecular" type="xs:boolean" default="false" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>If true, this interaction is an intramolecular interaction, e.g. an autophosphorylation. If missing, this element
                        is assumed to be false.</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="negative" type="xs:boolean" default="false" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>If true, this interaction has been shown NOT to occur under the described experimental conditions. Default false.
                        If this optional element is missing, it is assumed to be set to false.</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="confidenceList" type="mif:confidenceList" minOccurs="0"/>
            <xs:element name="parameterList" type="mif:parameterList" minOccurs="0"/>
            <xs:element name="experimentalVariableValueList" type="mif:experimentalVariableValueList" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>A list of variable/dynamic parameters used in this experiment to investigate dynamic interactions.</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="causalRelationshipList" type="mif:causalRelationshipList" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>A list of causal relationships involving participants in this interaction</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="attributeList" type="mif:attributeList" minOccurs="0"/>
        </xs:sequence>
        <xs:attribute name="imexId" type="xs:string" use="optional"/>
        <xs:attribute name="id" type="xs:int" use="required">
            <xs:annotation>
                <xs:documentation>All major objects have a numerical id which is unique to that object within a PSI MI file. The object may be repeated,
                    though, e.g. in the denormalised representation.</xs:documentation>
            </xs:annotation>
        </xs:attribute>
    </xs:complexType>

    <xs:complexType name="abstractInteraction">
        <xs:annotation>
            <xs:documentation>An 'abstract' molecular interaction - e.g - stable complexes, allosteric interaction, ....
                These interactions are abstracted from their experimental context and represent biological entities.</xs:documentation>
        </xs:annotation>
        <xs:sequence>
            <xs:element name="names" type="mif:names" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>Name(s) of the interaction.</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="xref" type="mif:xref" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>Interaction database ID, interaction evidence references</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="participantList" type="mif:abstractParticipantList"/>
            <xs:element name="bindingFeatureList" type="mif:bindingFeatureList" minOccurs="0"/>
            <xs:element name="interactionType" type="mif:cvType" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>External controlled vocabulary characterising the interaction type,
                        for example "physical interaction".</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="intraMolecular" type="xs:boolean" default="false" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>If true, this interaction is an intramolecular interaction, e.g. an autophosphorylation. If missing, this element
                        is assumed to be false.</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="confidenceList" type="mif:abstractConfidenceList" minOccurs="0"/>
            <xs:element name="parameterList" type="mif:abstractParameterList" minOccurs="0"/>
            <xs:element name="organism" type="mif:bioSource" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>The organism where this complex/abstract interaction naturally occurs.</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="interactorType" type="mif:cvType" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>The interactor type for this complex when it is used as a participant of another interaction.</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="evidenceType" type="mif:cvType" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>External controlled vocabulary characterising the evidence type (usually from the Evidence Ontology),
                        for example "physical interaction evidence, inferred from literature".</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="cooperativeEffectList" type="mif:cooperativeEffectList" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>A list of cooperative effects this interaction has on subsequent interactions, either through an allosteric or
                        pre-assembly effect.</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="causalRelationshipList" type="mif:causalRelationshipList" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>A list of causal relationships involving participants in this interaction</xs:documentation>
                </xs:annotation>
            </xs:element>

            <xs:element name="attributeList" type="mif:attributeList" minOccurs="0"/>
        </xs:sequence>
        <xs:attribute name="id" type="xs:int" use="required">
            <xs:annotation>
                <xs:documentation>All major objects have a numerical id which is unique to that object within a PSI MI file. The object may be repeated,
                    though, e.g. in the denormalised representation.</xs:documentation>
            </xs:annotation>
        </xs:attribute>
    </xs:complexType>

    <xs:complexType name="causalRelationshipList">
        <xs:annotation>
            <xs:documentation>A list of causal relationships involving participants in a specific interaction.</xs:documentation>
        </xs:annotation>
        <xs:sequence>
            <xs:element name="causalRelationship" type="mif:causalRelationship" minOccurs="1" maxOccurs="unbounded">
                <xs:annotation>
                    <xs:documentation>The causal relationship between a participant source and a participant target.</xs:documentation>
                </xs:annotation>
            </xs:element>
        </xs:sequence>
    </xs:complexType>

    <xs:complexType name="causalRelationship">
        <xs:annotation>
            <xs:documentation>The causal relationship between a participant source and a participant target.</xs:documentation>
        </xs:annotation>
        <xs:sequence>
            <xs:element name="sourceParticipantRef" type="xs:int" minOccurs="1" maxOccurs="1">
                <xs:annotation>
                    <xs:documentation>Refers to the participant that is the source of the causality statement.</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="causalityStatement" type="mif:openCvType" minOccurs="1" maxOccurs="1">
                <xs:annotation>
                    <xs:documentation>The causality statement. Allows to reference an external controlled vocabulary, or to directly include a value if no suitable external definition
                        is available.</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="targetParticipantRef" type="xs:int" minOccurs="1" maxOccurs="1">
                <xs:annotation>
                    <xs:documentation>Refers to the participant that is the target of the causality statement.</xs:documentation>
                </xs:annotation>
            </xs:element>
        </xs:sequence>
    </xs:complexType>

    <xs:complexType name="cooperativeEffectList">
        <xs:annotation>
            <xs:documentation>A list of cooperative effects this interaction has on subsequent interactions, either through an allosteric or pre-assembly effect.</xs:documentation>
        </xs:annotation>
        <xs:sequence>
            <xs:choice minOccurs="1" maxOccurs="unbounded">
                <xs:annotation>
                    <xs:documentation>The cooperative mechanism can be either allostery or pre-assembly.</xs:documentation>
                </xs:annotation>
                <xs:element name="allostery" type="mif:allostery">
                    <xs:annotation>
                        <xs:documentation>In case the cooperative mechanism is allostery.</xs:documentation>
                    </xs:annotation>
                </xs:element>
                <xs:element name="preassembly" type="mif:cooperativeEffectType">
                    <xs:annotation>
                        <xs:documentation>In case the cooperative mechanism is pre-assembly.</xs:documentation>
                    </xs:annotation>
                </xs:element>
            </xs:choice>
        </xs:sequence>
    </xs:complexType>
    <xs:complexType name="allostery">
        <xs:annotation>
            <xs:documentation>In case the cooperative mechanism is allostery.</xs:documentation>
        </xs:annotation>
        <xs:complexContent>
            <xs:extension base="mif:cooperativeEffectType">
                <xs:sequence>
                    <xs:element name="allostericMoleculeRef" type="xs:int" minOccurs="1" maxOccurs="1">
                        <xs:annotation>
                            <xs:documentation>Refers to the participant that is allosterically regulated.</xs:documentation>
                        </xs:annotation>
                    </xs:element>
                    <xs:choice minOccurs="1">
                        <xs:element name="allostericEffectorRef" type="xs:int" minOccurs="1" maxOccurs="1">
                            <xs:annotation>
                                <xs:documentation>Refers to the participant that elicits an allosteric response in an allosteric molecule upon
                                    binding to that molecule.</xs:documentation>
                            </xs:annotation>
                        </xs:element>
                        <xs:element name="allostericModificationRef" type="xs:int" minOccurs="1" maxOccurs="1">
                            <xs:annotation>
                                <xs:documentation>Refers to the modification (feature) that elicits an allosteric response in an allosteric molecule.</xs:documentation>
                            </xs:annotation>
                        </xs:element>
                    </xs:choice>
                    <xs:element name="allostericMechanism" type="mif:cvType" minOccurs="0" maxOccurs="1">
                        <xs:annotation>
                            <xs:documentation>Indicates the type of changes that occur in an allosteric molecule upon allosteric modification or
                                binding of an allosteric effector and result in an allosteric response. This element is controlled by the PSI-MI
                                controlled vocabulary "allosteric mechanism", root term id MI:1164.</xs:documentation>
                        </xs:annotation>
                    </xs:element>
                    <xs:element name="allosteryType" type="mif:cvType" minOccurs="0" maxOccurs="1">
                        <xs:annotation>
                            <xs:documentation>Indicates the chemical relationship between the ligands whose binding is allosterically coupled.
                                This element is controlled by the PSI-MI controlled vocabulary "allostery type", root term id MI:1167.</xs:documentation>
                        </xs:annotation>
                    </xs:element>
                </xs:sequence>
            </xs:extension>
        </xs:complexContent>
    </xs:complexType>
    <xs:complexType name="cooperativeEffectType">
        <xs:annotation>
            <xs:documentation>A cooperative effect an interaction has on a subsequent interaction.</xs:documentation>
        </xs:annotation>
        <xs:sequence>
            <xs:element name="cooperativityEvidenceList">
                <xs:annotation>
                    <xs:documentation>List of experimental methods and publications from which this cooperative effect has been inferred.</xs:documentation>
                </xs:annotation>
                <xs:complexType>
                    <xs:sequence>
                        <xs:element name="cooperativityEvidenceDescription" type="mif:evidenceType" minOccurs="1" maxOccurs="unbounded">
                        </xs:element>
                    </xs:sequence>
                </xs:complexType>
            </xs:element>
            <xs:element name="affectedInteractionList">
                <xs:annotation>
                    <xs:documentation>List of model interactions affected by this model interaction.</xs:documentation>
                </xs:annotation>
                <xs:complexType>
                    <xs:sequence>
                        <xs:element name="affectedInteractionRef" type="xs:int" minOccurs="1" maxOccurs="unbounded">
                            <xs:annotation>
                                <xs:documentation>Refers to the model interaction that is affected by the current model interaction.</xs:documentation>
                            </xs:annotation>
                        </xs:element>
                    </xs:sequence>
                </xs:complexType>
            </xs:element>
            <xs:element name="cooperativeEffectOutcome" type="mif:cvType" minOccurs="1" maxOccurs="1">
                <xs:annotation>
                    <xs:documentation>Indicates whether the cooperative effect is positive (either induced or enhanced) or negative
                        (either inhibited or abrogated). This element is controlled by the PSI-MI controlled vocabulary "cooperative effect outcome"
                        root term, id MI:1153.</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="cooperativeEffectResponse" type="mif:cvType" minOccurs="0" maxOccurs="1">
                <xs:annotation>
                    <xs:documentation>Indicates how the cooperative mechanism affects another interaction. This element is controlled by the PSI-MI
                        controlled vocabulary "cooperative effect response" root term, id MI:.</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="attributeList" type="mif:attributeList" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>Semi-structured additional description of the data contained in the cooperative effect.</xs:documentation>
                </xs:annotation>
            </xs:element>
        </xs:sequence>
    </xs:complexType>
    <xs:complexType name="evidenceType">
        <xs:annotation>
            <xs:documentation>List of experimental methods and corresponding publication from which this cooperative effect has been inferred.</xs:documentation>
        </xs:annotation>
        <xs:sequence>
            <xs:element name="bibref" type="mif:bibref" minOccurs="1" maxOccurs="1">
                <xs:annotation>
                    <xs:documentation>Publication describing the experiments from which this cooperative effect has been inferred.</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="evidenceMethodList" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>Experimental methods from which this cooperative effect has been inferred.</xs:documentation>
                </xs:annotation>
                <xs:complexType>
                    <xs:sequence>
                        <xs:element name="evidenceMethod" type="mif:cvType" minOccurs="1" maxOccurs="unbounded"/>
                    </xs:sequence>
                </xs:complexType>
            </xs:element>
        </xs:sequence>
    </xs:complexType>

    <xs:complexType name="abstractParticipantList">
        <xs:annotation>
            <xs:documentation>A list of molecules participating in an abstract interaction. A complex has one
                (homo-dimers), two (binary), or more (complexes) participants. As the interaction is abstracted from the experimental context, the
                participants are also abstracted from any experimental context.
            </xs:documentation>
        </xs:annotation>
        <xs:sequence>
            <xs:element name="participant" type="mif:abstractParticipant" maxOccurs="unbounded"/>
        </xs:sequence>
    </xs:complexType>
    <xs:complexType name="abstractParticipant">
        <xs:annotation>
            <xs:documentation>A molecule participating in an interaction (complex, allsoteric interaction, ...).
                This participant is abstracted from its experimental context.</xs:documentation>
        </xs:annotation>
        <xs:sequence>
            <xs:element name="names" type="mif:names" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>Names for the participant</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="xref" type="mif:xref" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>Contains the xref(s) for the participant.</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:choice>
                <xs:annotation>
                    <xs:documentation>Description of the Interactor. Refers to an already defined interactor in this entry, fully describes an
                        interactor, references another interaction defined in this entry, to allow the hierarchical building up of complexes from
                        subunits, or describe a molecule set (several molecules can interact but it cannot be determined which one interacts).. </xs:documentation>
                </xs:annotation>
                <xs:element name="interactorRef" type="xs:int">
                    <xs:annotation>
                        <xs:documentation>References an interactor described in the interactorList of the entry</xs:documentation>
                    </xs:annotation>
                </xs:element>
                <xs:element name="interactor" type="mif:interactor">
                    <xs:annotation>
                        <xs:documentation>Fully describes an interactor</xs:documentation>
                    </xs:annotation>
                </xs:element>
                <xs:element name="interactionRef" type="xs:int">
                    <xs:annotation>
                        <xs:documentation>References an abstract interaction described in this entry. Used for the hierarchical buildup of complexes.</xs:documentation>
                    </xs:annotation>
                </xs:element>
                <xs:element name="interactorCandidateList" type="mif:abstractInteractorCandidateList">
                    <xs:annotation>
                        <xs:documentation>A molecule set (several molecules can interact but it cannot be determined which one interacts)</xs:documentation>
                    </xs:annotation>
                </xs:element>
            </xs:choice>
            <xs:element name="biologicalRole" type="mif:cvType" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>The role of the participant in the interaction. This describes the biological role, e.g. enzyme or enzyme target.
                        The experimental role of the participant, e.g. 'bait', is shown in experimentalForm. This element is controlled by the PSI-MI
                        controlled vocabulary "biologicalRole", root term id MI:0500.</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="featureList" type="mif:abstractFeatureList" minOccurs="0"/>
            <xs:choice minOccurs="0">
                <xs:annotation>
                    <xs:documentation>Description of the participant stoichiometry. Can be a single stoichiometry or a stoichiometry range.</xs:documentation>
                </xs:annotation>
                <xs:element name="stoichiometry" type="mif:stoichiometryType">
                    <xs:annotation>
                        <xs:documentation>The stoichiometry of the participant.</xs:documentation>
                    </xs:annotation>
                </xs:element>
                <xs:element name="stoichiometryRange" type="mif:stoichiometryRangeType">
                    <xs:annotation>
                        <xs:documentation>The stoichiometry range of the participant.</xs:documentation>
                    </xs:annotation>
                </xs:element>
            </xs:choice>
            <xs:element name="attributeList" type="mif:attributeList" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>Semi-structured additional description of the data contained in the entry.</xs:documentation>
                </xs:annotation>
            </xs:element>
        </xs:sequence>
        <xs:attribute name="id" type="xs:int" use="required"/>
    </xs:complexType>

    <xs:complexType name="participantCandidateParent">
        <xs:annotation>
            <xs:documentation>A molecule which is part of a molecule set (MI:1304) participating in an interaction.
                This molecule does not interacts with the other participant candidates. A molecule set is a group of molecules
                linked by a high degree of similarity of sequence and/or function and not easily separated by
                participant identification methods. It means that we cannot determine for sure which molecules of the molecule set is the participant
                of this interaction.
            </xs:documentation>
        </xs:annotation>
        <xs:sequence>
            <xs:choice>
                <xs:annotation>
                    <xs:documentation>Description of the Interactor. Refers to an already defined interactor in this entry or fully describes an
                        interactor. </xs:documentation>
                </xs:annotation>
                <xs:element name="interactorRef" type="xs:int">
                    <xs:annotation>
                        <xs:documentation>References an interactor described in the interactorList of the entry</xs:documentation>
                    </xs:annotation>
                </xs:element>
                <xs:element name="interactor" type="mif:interactor">
                    <xs:annotation>
                        <xs:documentation>Fully describes an interactor</xs:documentation>
                    </xs:annotation>
                </xs:element>
            </xs:choice>
        </xs:sequence>
        <xs:attribute name="id" type="xs:int" use="required"/>
    </xs:complexType>

    <xs:complexType name="abstractParticipantCandidate">
        <xs:complexContent>
            <xs:extension base="mif:participantCandidateParent">
                <xs:sequence>
                    <xs:element name="featureList" type="mif:abstractFeatureList" minOccurs="0"/>
                </xs:sequence>
            </xs:extension>
        </xs:complexContent>
    </xs:complexType>

    <xs:complexType name="participantCandidate">
        <xs:complexContent>
            <xs:extension base="mif:participantCandidateParent">
                <xs:sequence>
                    <xs:element name="featureList" type="mif:featureList" minOccurs="0"/>
                </xs:sequence>
            </xs:extension>
        </xs:complexContent>
    </xs:complexType>

    <xs:complexType name="participantList">
        <xs:annotation>
            <xs:documentation>A list of molecules participating in this interaction. An interaction has one
                (intramolecular), two (binary), or more (n-ary, complexes) participants.
            </xs:documentation>
        </xs:annotation>
        <xs:sequence>
            <xs:element name="participant" type="mif:participant" maxOccurs="unbounded"/>
        </xs:sequence>
    </xs:complexType>

    <xs:complexType name="bindingFeatureList">
        <xs:annotation>
            <xs:documentation>Show the topology of interactions within a complex.
            </xs:documentation>
        </xs:annotation>
        <xs:sequence>
            <xs:element name="bindingFeatures" type="mif:bindingFeatures" maxOccurs="unbounded"/>
        </xs:sequence>
    </xs:complexType>

    <xs:complexType name="bindingFeatures">
        <xs:annotation>
            <xs:documentation>List all the features reported in the complex that are linked to each other.
            </xs:documentation>
        </xs:annotation>
        <xs:sequence>
            <xs:element name="participantFeatureRef" type="xs:int" minOccurs="2" maxOccurs="unbounded"/>
        </xs:sequence>
    </xs:complexType>

    <xs:complexType name="inferredInteractionList">
        <xs:annotation>
            <xs:documentation>Describes inferred interactions, usually combining data from more than one experiment.
                Examples: 1: Show the topology of binary interactions within a complex. 2: Interaction inferred from
                multiple experiments which on their own would not support the interaction. Example: A-B in experiment 1,
                B-C- in experiment 2, A-C is the inferred interaction.
            </xs:documentation>
        </xs:annotation>
        <xs:sequence>
            <xs:element name="inferredInteraction" type="mif:inferredInteraction" maxOccurs="unbounded"/>
        </xs:sequence>
    </xs:complexType>

    <xs:complexType name="inferredInteraction">
        <xs:sequence>
            <xs:element name="participant" type="mif:inferredInteractionParticipant" minOccurs="2" maxOccurs="unbounded"/>
            <xs:element name="experimentRefList" type="mif:experimentRefList" minOccurs="0"/>
        </xs:sequence>
    </xs:complexType>

    <xs:complexType name="inferredInteractionParticipant">
        <xs:annotation>
            <xs:documentation>Participant of the inferred interaction.</xs:documentation>
        </xs:annotation>
        <xs:choice>
            <xs:element name="participantRef" type="xs:int"/>
            <xs:element name="participantFeatureRef" type="xs:int"/>
        </xs:choice>
    </xs:complexType>

    <!--interactors and participants-->
    <xs:complexType name="interactor">
        <xs:annotation>
            <xs:documentation>Describes a molecular interactor.</xs:documentation>
        </xs:annotation>
        <xs:sequence>
            <xs:element name="names" type="mif:names">
                <xs:annotation>
                    <xs:documentation>Name(s).  The short label is typically a short name that could appear as a label on a diagram.</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="xref" type="mif:xref" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>An interactor should have an xref whenever possible. If the interactor is not available in external databases,
                        it must be characterised within this object e.g. by its sequence.</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="interactorType" type="mif:cvType">
                <xs:annotation>
                    <xs:documentation>The molecule type of the participant, e.g. protein. This element is controlled by the PSI-MI controlled vocabulary
                        "interactor", root term id MI:0313.</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="organism" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>The normal source organism of the interactor.</xs:documentation>
                </xs:annotation>
                <xs:complexType>
                    <xs:complexContent>
                        <xs:extension base="mif:bioSource"/>
                    </xs:complexContent>
                </xs:complexType>
            </xs:element>
            <xs:element name="sequence" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>Sequence in uppercase</xs:documentation>
                    <xs:documentation>Usage:</xs:documentation>
                </xs:annotation>
                <xs:simpleType>
                    <xs:restriction base="xs:string">
                        <xs:minLength value="1"/>
                    </xs:restriction>
                </xs:simpleType>
            </xs:element>
            <xs:element name="attributeList" type="mif:attributeList" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>Allows semi-structured additional annotation of the interactor.</xs:documentation>
                </xs:annotation>
            </xs:element>
        </xs:sequence>
        <xs:attribute name="id" type="xs:int" use="required">
            <xs:annotation>
                <xs:documentation>All major objects have a numerical id which is unique to that object within a PSI MI file. The object may be repeated,
                    though, e.g. in the denormalised representation.</xs:documentation>
            </xs:annotation>
        </xs:attribute>
    </xs:complexType>
    <xs:complexType name="participant">
        <xs:annotation>
            <xs:documentation>A molecule participating in an interaction.</xs:documentation>
        </xs:annotation>
        <xs:sequence>
            <xs:element name="names" type="mif:names" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>This contains the name(s) for the participant given by the authors of a publication.</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="xref" type="mif:xref" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>Contains the xref(s) for the participant given by the authors of a publication.</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:choice>
                <xs:annotation>
                    <xs:documentation>Description of the Interactor. Refers to an already defined interactor in this entry, fully describes
                        an interactor, references another interaction defined in this entry, to allow the hierarchical building up of complexes
                        from subunits, or describe a molecule set (several molecules can interact but it cannot be determined which one interacts). </xs:documentation>
                </xs:annotation>
                <xs:element name="interactorRef" type="xs:int">
                    <xs:annotation>
                        <xs:documentation>References an interactor described in the interactorList of the entry</xs:documentation>
                    </xs:annotation>
                </xs:element>
                <xs:element name="interactor" type="mif:interactor">
                    <xs:annotation>
                        <xs:documentation>Fully describes an interactor</xs:documentation>
                    </xs:annotation>
                </xs:element>
                <xs:element name="interactionRef" type="xs:int">
                    <xs:annotation>
                        <xs:documentation>References an interaction described in this entry. Used for the hierarchical buildup of complexes.</xs:documentation>
                    </xs:annotation>
                </xs:element>
                <xs:element name="interactorCandidateList" type="mif:interactorCandidateList">
                    <xs:annotation>
                        <xs:documentation>A molecule set (several molecules can interact but it cannot be determined which one interacts)</xs:documentation>
                    </xs:annotation>
                </xs:element>
            </xs:choice>
            <xs:element name="participantIdentificationMethodList" type="mif:participantIdentificationMethodList" minOccurs="0"/>
            <xs:element name="biologicalRole" type="mif:cvType" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>The role of the participant in the interaction. This describes the biological role, e.g. enzyme or enzyme target.
                        The experimental role of the participant, e.g. 'bait', is shown in experimentalForm. This element is controlled by the PSI-MI
                        controlled vocabulary "biologicalRole", root term id MI:0500.</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="experimentalRoleList" type="mif:experimentalRoleList" minOccurs="0"/>
            <xs:element name="experimentalPreparationList" type="mif:experimentalPreparationList" minOccurs="0"/>
            <xs:element name="experimentalInteractorList" type="mif:experimentalInteractorList" minOccurs="0"/>
            <xs:element name="featureList" type="mif:featureList" minOccurs="0"/>
            <xs:element name="hostOrganismList" type="mif:hostOrganismList" minOccurs="0"/>
            <xs:element name="confidenceList" type="mif:confidenceList" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>Confidence in participant detection.</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="parameterList" type="mif:parameterList" minOccurs="0"/>
            <xs:choice minOccurs="0">
                <xs:annotation>
                    <xs:documentation>Description of the participant stoichiometry. Can be a single stoichiometry or a stoichiometry range.</xs:documentation>
                </xs:annotation>
                <xs:element name="stoichiometry" type="mif:stoichiometryType">
                    <xs:annotation>
                        <xs:documentation>The stoichiometry of the participant.</xs:documentation>
                    </xs:annotation>
                </xs:element>
                <xs:element name="stoichiometryRange" type="mif:stoichiometryRangeType">
                    <xs:annotation>
                        <xs:documentation>The stoichiometry range of the participant.</xs:documentation>
                    </xs:annotation>
                </xs:element>
            </xs:choice>
            <xs:element name="attributeList" type="mif:attributeList" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>Semi-structured additional description of the data contained in the entry.</xs:documentation>
                </xs:annotation>
            </xs:element>
        </xs:sequence>
        <xs:attribute name="id" type="xs:int" use="required"/>
    </xs:complexType>

    <xs:complexType name="stoichiometryType">
        <xs:annotation>
            <xs:documentation>The mean value for the participant stoichiometry.
            </xs:documentation>
        </xs:annotation>
        <xs:attribute name="value" type="xs:int" use="required">
            <xs:annotation>
                <xs:documentation>The participant stoichiometry value</xs:documentation>
            </xs:annotation>
        </xs:attribute>
    </xs:complexType>

    <xs:complexType name="stoichiometryRangeType">
        <xs:annotation>
            <xs:documentation>The stoichiometry range of a participant.
            </xs:documentation>
        </xs:annotation>
        <xs:attribute name="minValue" type="xs:int" use="required">
            <xs:annotation>
                <xs:documentation>The minimum stoichiometry value</xs:documentation>
            </xs:annotation>
        </xs:attribute>
        <xs:attribute name="maxValue" type="xs:int" use="required">
            <xs:annotation>
                <xs:documentation>The maximum stoichiometry value</xs:documentation>
            </xs:annotation>
        </xs:attribute>
    </xs:complexType>

    <xs:complexType name="participantIdentificationMethodList">
        <xs:annotation>
            <xs:documentation>The method(s) by which this participant has been determined. If this element is present,
                its value supersedes experimentDescription/ participantIdentificationMethod.
            </xs:documentation>
        </xs:annotation>
        <xs:sequence>
            <xs:element name="participantIdentificationMethod" type="mif:participantIdentificationMethod" maxOccurs="unbounded"/>
        </xs:sequence>
    </xs:complexType>

    <xs:complexType name="participantIdentificationMethod">
        <xs:annotation>
            <xs:documentation>Experimental method to determine the interactors involved in the interaction. This
                element is controlled by the PSI-MI controlled vocabulary "participant identification method",
                root term id MI:0002.
            </xs:documentation>
        </xs:annotation>
        <xs:complexContent>
            <xs:extension base="mif:cvType">
                <xs:sequence minOccurs="0">
                    <xs:element name="experimentRefList" type="mif:experimentRefList" minOccurs="0">
                        <xs:annotation>
                            <xs:documentation>If no experimentRef is given, it is assumed this refers to all
                                experiments linked to the interaction.
                            </xs:documentation>
                        </xs:annotation>
                    </xs:element>
                </xs:sequence>
            </xs:extension>
        </xs:complexContent>
    </xs:complexType>

    <xs:complexType name="experimentalRoleList">
        <xs:annotation>
            <xs:documentation>The role(s) of the participant in the interaction, e.g. bait.</xs:documentation>
        </xs:annotation>
        <xs:sequence>
            <xs:element name="experimentalRole" type="mif:experimentalRole" maxOccurs="unbounded"/>
        </xs:sequence>
    </xs:complexType>

    <xs:complexType name="interactorCandidateList">
        <xs:annotation>
            <xs:documentation>The list of interactor candidates.</xs:documentation>
        </xs:annotation>
        <xs:sequence>
            <xs:element name="moleculeSetType" type="mif:cvType" minOccurs="1">
                <xs:annotation>
                    <xs:documentation>The type of molecule set, e.g. candidate set, defined set, ...
                        This element is controlled by the PSI-MI controlled vocabulary
                        "interactor", root term id MI:1304.</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="interactorCandidate" type="mif:participantCandidate" maxOccurs="unbounded" minOccurs="1"/>
        </xs:sequence>
    </xs:complexType>

    <xs:complexType name="abstractInteractorCandidateList">
        <xs:annotation>
            <xs:documentation>The list of interactor candidates.</xs:documentation>
        </xs:annotation>
        <xs:sequence>
            <xs:element name="moleculeSetType" type="mif:cvType" minOccurs="1">
                <xs:annotation>
                    <xs:documentation>The type of molecule set, e.g. candidate set, defined set, ...
                        This element is controlled by the PSI-MI controlled vocabulary
                        "interactor", root term id MI:1304.</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="interactorCandidate" type="mif:abstractParticipantCandidate" maxOccurs="unbounded" minOccurs="1"/>
        </xs:sequence>
    </xs:complexType>

    <xs:complexType name="experimentalRole">
        <xs:annotation>
            <xs:documentation>This element is controlled by the PSI-MI controlled vocabulary "experimentalRole",
                root term id MI:0495.
            </xs:documentation>
        </xs:annotation>
        <xs:complexContent>
            <xs:extension base="mif:cvType">
                <xs:sequence minOccurs="0">
                    <xs:element name="experimentRefList" type="mif:experimentRefList" minOccurs="0">
                        <xs:annotation>
                            <xs:documentation>If no experimentRef is given, it is assumed this refers to all
                                experiments linked to the interaction.
                            </xs:documentation>
                        </xs:annotation>
                    </xs:element>
                </xs:sequence>
            </xs:extension>
        </xs:complexContent>
    </xs:complexType>

    <xs:complexType name="experimentalPreparationList">
        <xs:annotation>
            <xs:documentation>Terms describing the experimental sample preparation.</xs:documentation>
        </xs:annotation>
        <xs:sequence>
            <xs:element name="experimentalPreparation" type="mif:experimentalPreparation" maxOccurs="unbounded"/>
        </xs:sequence>
    </xs:complexType>

    <xs:complexType name="experimentalPreparation">
        <xs:annotation>
            <xs:documentation>This element is controlled by the PSI-MI controlled vocabulary
                "experimentalPreparation", root term id MI:0346.
            </xs:documentation>
        </xs:annotation>
        <xs:complexContent>
            <xs:extension base="mif:cvType">
                <xs:sequence minOccurs="0">
                    <xs:element name="experimentRefList" type="mif:experimentRefList" minOccurs="0">
                        <xs:annotation>
                            <xs:documentation>If no experimentRef is given, it is assumed this refers to all
                                experiments linked to the interaction.
                            </xs:documentation>
                        </xs:annotation>
                    </xs:element>
                </xs:sequence>
            </xs:extension>
        </xs:complexContent>
    </xs:complexType>

    <xs:complexType name="experimentalInteractorList">
        <xs:annotation>
            <xs:documentation>Describes molecules which have been used in specific experiments if these molecules are
                different from the one listed as interactors. Example: The author of a paper makes a statement about
                human proteins, but has really worked with mouse proteins. In this case the human protein would be the
                main interactor, while the experimentalForm would be the mouse protein listed in this element.
                Optionally this can refer to the experiment(s) in which this form has been used.
            </xs:documentation>
        </xs:annotation>
        <xs:sequence>
            <xs:element name="experimentalInteractor" type="mif:experimentalInteractor" maxOccurs="unbounded"/>
        </xs:sequence>
    </xs:complexType>

    <xs:complexType name="experimentalInteractor">
        <xs:sequence>
            <xs:choice>
                <xs:annotation>
                    <xs:documentation>Either refer to an already defined protein interactor in this entry or insert
                        description.
                    </xs:documentation>
                </xs:annotation>
                <xs:element name="interactorRef" type="xs:int">
                    <xs:annotation>
                        <xs:documentation>References an interactor described in the interactorList of the entry
                        </xs:documentation>
                    </xs:annotation>
                </xs:element>
                <xs:element name="interactor" type="mif:interactor">
                    <xs:annotation>
                        <xs:documentation>Fully describes an interactor</xs:documentation>
                    </xs:annotation>
                </xs:element>
            </xs:choice>
            <xs:element name="experimentRefList" type="mif:experimentRefList" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>If no experimentRef is given, it is assumed this refers to all experiments linked
                        to the interaction.
                    </xs:documentation>
                </xs:annotation>
            </xs:element>
        </xs:sequence>
    </xs:complexType>

    <xs:complexType name="abstractFeatureList">
        <xs:annotation>
            <xs:documentation>Sequence features relevant for the abstract interaction. These features are abstracted from any experimental context
                and are usually binding sites, variants, etc..
            </xs:documentation>
        </xs:annotation>
        <xs:sequence>
            <xs:element name="feature" type="mif:abstractFeature" maxOccurs="unbounded"/>
        </xs:sequence>
    </xs:complexType>
    <xs:complexType name="abstractFeature">
        <xs:annotation>
            <xs:documentation>A biological feature, e.g. domain, on a sequence.</xs:documentation>
        </xs:annotation>
        <xs:sequence>
            <xs:element name="names" type="mif:names" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>Names for the feature, e.g. SH3 domain.</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="xref" type="mif:xref" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>Reference to an external feature description, for example InterPro entry.</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="featureType" type="mif:cvType" maxOccurs="1" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>Description and classification of the feature. This element is controlled by the PSI-MI controlled vocabulary
                        "feature",
                        root term id MI:0116.</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="featureRangeList">
                <xs:complexType>
                    <xs:sequence>
                        <xs:element name="featureRange" type="mif:baseLocation" maxOccurs="unbounded">
                            <xs:annotation>
                                <xs:documentation>Location of the feature on the sequence of the interactor. One feature may have more than one
                                    featureRange, used e.g. for features which involve sequence positions close in the folded, three-dimensional
                                    state of a protein, but non-continuous along the sequence.</xs:documentation>
                            </xs:annotation>
                        </xs:element>
                    </xs:sequence>
                </xs:complexType>
            </xs:element>
            <xs:element name="featureRole" type="mif:cvType" minOccurs="0" maxOccurs="1">
                <xs:annotation>
                    <xs:documentation>The role of the feature in the context of this interaction. It usually describes the impact of
                        the interaction on the feature. (Ex: resulting-ptm, ...) or the impact of the feature on the interaction.
                        (Ex: prerequisite-ptm,...).</xs:documentation>
                </xs:annotation>
            </xs:element>
            <xs:element name="attributeList" type="mif:attributeList" minOccurs="0">
                <xs:annotation>
                    <xs:documentation>Semi-structured additional description of the data contained in the entry.</xs:documentation>
                </xs:annotation>
            </xs:element>
        </xs:sequence>
        <xs:attribute name="id" type="xs:int" use="required"/>
    </xs:complexType>

    <xs:complexType name="featureList">
        <xs:annotation>
            <xs:documentation>Sequence features relevant for the interaction, for example binding domains, and
                experimental modifications, e.g. protein tags.
            </xs:documentation>
        </xs:annotation>
        <xs:sequence>
            <xs:element name="feature" type="mif:feature" maxOccurs="unbounded"/>
        </xs:sequence>
    </xs:complexType>

    <xs:complexType name="abstractParameterList">
        <xs:annotation>
            <xs:documentation>Lists parameters which are relevant for the complex/abstract interaction, e.g. kinetics.
            These parameters can refer to their original publication.</xs:documentation>
        </xs:annotation>
        <xs:sequence>
            <xs:element name="parameter" type="mif:abstractParameter" maxOccurs="unbounded"/>
        </xs:sequence>
    </xs:complexType>

    <xs:complexType name="abstractParameter">
        <xs:complexContent>
            <xs:extension base="mif:parameterBase">
                <xs:sequence>
                    <xs:element name="bibref" type="mif:bibref" minOccurs="0">
                        <xs:annotation>
                            <xs:documentation>Reference to the publication (or publications) where this parameter has been shown.
                            </xs:documentation>
                        </xs:annotation>
                    </xs:element>
                </xs:sequence>
                <xs:attribute name="uncertainty" type="xs:decimal" use="optional"/>
            </xs:extension>
        </xs:complexContent>
    </xs:complexType>

    <xs:complexType name="parameterList">
        <xs:annotation>
            <xs:documentation>Lists parameters which are relevant for the Interaction, e.g. kinetics.</xs:documentation>
        </xs:annotation>
        <xs:sequence>
            <xs:element name="parameter" type="mif:parameter" maxOccurs="unbounded"/>
        </xs:sequence>
    </xs:complexType>

    <xs:complexType name="parameter">
        <xs:complexContent>
            <xs:extension base="mif:parameterBase">
                <xs:sequence>
                    <xs:element name="experimentRef" type="xs:int" minOccurs="0" maxOccurs="1">
                        <xs:annotation>
                            <xs:documentation>Reference to the experiment in which this parameter has been
                                determined. If not given, it is assumed that this is valid for all
                                experiments attached to the interaction.
                            </xs:documentation>
                        </xs:annotation>
                    </xs:element>
                </xs:sequence>
                <xs:attribute name="uncertainty" type="xs:decimal" use="optional"/>
            </xs:extension>
        </xs:complexContent>
    </xs:complexType>
</xs:schema>