diff --git a/Library/Homebrew/extend/ENV/super.rb b/Library/Homebrew/extend/ENV/super.rb
index bacc76e7ea68a..3ac9ffeded65b 100644
--- a/Library/Homebrew/extend/ENV/super.rb
+++ b/Library/Homebrew/extend/ENV/super.rb
@@ -74,7 +74,6 @@ def setup_build_environment(formula: nil, cc: nil, build_bottle: false, bottle_a
     self["CMAKE_INCLUDE_PATH"] = determine_cmake_include_path
     self["CMAKE_LIBRARY_PATH"] = determine_cmake_library_path
     self["ACLOCAL_PATH"] = determine_aclocal_path
-    self["M4"] = DevelopmentTools.locate("m4") if deps.any? { |d| d.name == "autoconf" }
     self["HOMEBREW_ISYSTEM_PATHS"] = determine_isystem_paths
     self["HOMEBREW_INCLUDE_PATHS"] = determine_include_paths
     self["HOMEBREW_LIBRARY_PATHS"] = determine_library_paths