diff --git a/.flake8 b/.flake8
index 68a21b79ec4a..37b70721bd4f 100644
--- a/.flake8
+++ b/.flake8
@@ -55,7 +55,6 @@ exclude =
     benchmarks/*.py,
     build,
     dpnp/_version.py,
-    dpnp/to_numba/*.py,
     conda.recipe,
     dpnp/tests/*.py,
     tests_external/*.py,
diff --git a/CHANGELOG.md b/CHANGELOG.md
index 3714735c9ba0..d4c45aa8d280 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -30,6 +30,7 @@ Also, that release drops support for Python 3.9, making Python 3.10 the minimum
 ### Removed
 
 * Dropped support for Python 3.9 [#2626](https://github.com/IntelPython/dpnp/pull/2626)
+* Removed the obsolete interface from DPNP to Numba JIT [#2647](https://github.com/IntelPython/dpnp/pull/2647)
 
 ### Fixed
 
diff --git a/dpnp/to_numba/__init__.py b/dpnp/to_numba/__init__.py
deleted file mode 100644
index 4d744953eb5b..000000000000
--- a/dpnp/to_numba/__init__.py
+++ /dev/null
@@ -1,30 +0,0 @@
-# -*- coding: utf-8 -*-
-# *****************************************************************************
-# Copyright (c) 2016, Intel Corporation
-# All rights reserved.
-#
-# Redistribution and use in source and binary forms, with or without
-# modification, are permitted provided that the following conditions are met:
-# - Redistributions of source code must retain the above copyright notice,
-#   this list of conditions and the following disclaimer.
-# - Redistributions in binary form must reproduce the above copyright notice,
-#   this list of conditions and the following disclaimer in the documentation
-#   and/or other materials provided with the distribution.
-# - Neither the name of the copyright holder nor the names of its contributors
-#   may be used to endorse or promote products derived from this software
-#   without specific prior written permission.
-#
-# THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS"
-# AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE
-# IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE
-# ARE DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT HOLDER OR CONTRIBUTORS BE
-# LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR
-# CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF
-# SUBSTITUTE GOODS OR SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS
-# INTERRUPTION) HOWEVER CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN
-# CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE)
-# ARISING IN ANY WAY OUT OF THE USE OF THIS SOFTWARE, EVEN IF ADVISED OF
-# THE POSSIBILITY OF SUCH DAMAGE.
-# *****************************************************************************
-
-from dpnp.to_numba.dpnp_iface_to_numba import *
diff --git a/dpnp/to_numba/dpnp_iface_to_numba.py b/dpnp/to_numba/dpnp_iface_to_numba.py
deleted file mode 100644
index 6e69c83363fd..000000000000
--- a/dpnp/to_numba/dpnp_iface_to_numba.py
+++ /dev/null
@@ -1,75 +0,0 @@
-# -*- coding: utf-8 -*-
-# *****************************************************************************
-# Copyright (c) 2016, Intel Corporation
-# All rights reserved.
-#
-# Redistribution and use in source and binary forms, with or without
-# modification, are permitted provided that the following conditions are met:
-# - Redistributions of source code must retain the above copyright notice,
-#   this list of conditions and the following disclaimer.
-# - Redistributions in binary form must reproduce the above copyright notice,
-#   this list of conditions and the following disclaimer in the documentation
-#   and/or other materials provided with the distribution.
-# - Neither the name of the copyright holder nor the names of its contributors
-#   may be used to endorse or promote products derived from this software
-#   without specific prior written permission.
-#
-# THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS"
-# AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE
-# IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE
-# ARE DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT HOLDER OR CONTRIBUTORS BE
-# LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR
-# CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF
-# SUBSTITUTE GOODS OR SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS
-# INTERRUPTION) HOWEVER CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN
-# CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE)
-# ARISING IN ANY WAY OUT OF THE USE OF THIS SOFTWARE, EVEN IF ADVISED OF
-# THE POSSIBILITY OF SUCH DAMAGE.
-# *****************************************************************************
-
-"""
-Interface between DPNP Algo (Cython) layer and Numba.
-
-Notes
------
-This module represents DPNP Algo interface to Numba JIT
-
-The code idea gathered from numba-scipy and needs to be synchronized with
-https://github.com/numba/numba-scipy/blob/master/numba_scipy/special/
-"""
-
-import ctypes
-
-import numba
-from numba.extending import get_cython_function_address as nba_addr
-
-name_to_numba_signatures = {
-    "cos": [
-        (numba.types.float64),
-    ]
-}
-
-name_and_types_to_pointer = {
-    ("cos", numba.types.float64): ctypes.CFUNCTYPE(
-        ctypes.c_double, ctypes.c_double
-    )(nba_addr("dpnp.dpnp_algo", "dpnp_cos"))
-}
-
-
-def choose_kernel(name, all_signatures):
-    def choice_function(*args):
-        for signature in all_signatures:
-            if args == signature:
-                f = name_and_types_to_pointer[(name, *signature)]
-                return lambda *args: f(*args)
-
-    return choice_function
-
-
-def add_overloads():
-    for name, all_signatures in name_to_numba_signatures.items():
-        sc_function = getattr(sc, name)
-        print(f"sc_function={sc_function}")
-        numba.extending.overload(sc_function)(
-            choose_kernel(name, all_signatures)
-        )