diff --git a/base/tuple.jl b/base/tuple.jl
index 59fe2c1e531e1..ae5de41586848 100644
--- a/base/tuple.jl
+++ b/base/tuple.jl
@@ -607,7 +607,6 @@ any(x::Tuple{Bool, Bool, Bool}) = x[1]|x[2]|x[3]
 
 # a version of `in` esp. for NamedTuple, to make it pure, and not compiled for each tuple length
 function sym_in(x::Symbol, @nospecialize itr::Tuple{Vararg{Symbol}})
-    @noinline
     @_total_meta
     for y in itr
         y === x && return true
diff --git a/test/tuple.jl b/test/tuple.jl
index 8ff311928b6b8..b806667fd9d0a 100644
--- a/test/tuple.jl
+++ b/test/tuple.jl
@@ -763,6 +763,12 @@ g42457(a, b) = Base.isequal(a, b) ? 1 : 2.0
 # issue #46049: setindex(::Tuple) regression
 @inferred Base.setindex((1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16), 42, 1)
 
+# issue #50562
+f50562(r) = in(:i_backward, r[])
+r50562 = Ref((:b_back, :foofakgka, :i_backw))
+f50562(r50562)
+@test @allocated(f50562(r50562)) == 0
+
 # issue #47326
 function fun1_47326(args...)
     head..., tail = args