Updates and improvements to the IMEter software
The IMEter is a tool that can help predict the effects of Intron-Mediated Enhancement (IME) on gene expression. After training from suitable input data, the IMEter can be used to score any desired intron sequence (with highers scores indicating a higher potential for enhancement).
Two papers have been published that describe the first two versions of the IMEter:
- IMEter v1.0: Rose, A, Elfersi, T, Parra G, Korf I. Promoter-Proximal Introns in Arabidopsis thaliana are enriched in dispersed signals that elevate gene expression. Plant Cell 2008, 20:543-551
- IMEter v2.0: Parra, G., Bradnam, K., Rose, A. and Korf, I. Comparative and functional analysis of intron-mediated enhancement signals reveals conserved features among plants. Nucleic Acids Research, 2011.
This GitHub repository will track development on the latest — as yet unpublished — version of the IMEter (v2.1) as well as the intitial work on the next generation of the software (IMEter v2.2). Please see the following two READMEs for more details: