diff --git a/samples/sampleset_domain_example.py b/samples/sampleset_domain_example.py
new file mode 100644
index 0000000..7f251f6
--- /dev/null
+++ b/samples/sampleset_domain_example.py
@@ -0,0 +1,91 @@
+from __future__ import unicode_literals
+
+from labkey.utils import create_server_context
+from labkey import domain
+
+labkey_server = 'localhost:8080'
+project_name = 'MySamples'  # Project folder name
+context_path = 'labkey'
+server_context = create_server_context(labkey_server, project_name, context_path, use_ssl=False)
+
+###################
+# Create a SampleSet domain
+###################
+sampleset_domain_definition = {
+    'kind': 'SampleSet', 
+    'domainDesign': {
+        'name': 'BloodSamples',
+        'description': 'Human blood samples.',
+        'fields': [{
+          'name': "Name", 
+          'rangeURI': "string"
+        },{
+          'name': "volume_mL", 
+          'rangeURI': "int"
+        },{
+          'name': "Project",
+          'rangeURI': "string"
+        },{
+          'name': "DrawDate",
+          'rangeURI': "dateTime"
+        },{
+          'name': "ReceivedDate",
+          'rangeURI': "dateTime"
+        },{
+          'name': "ReceivedFrom",
+          'rangeURI': "string"
+        },{
+          'name': "ReceivingOperator",
+          'rangeURI': "string"
+        },{
+          'name': "TubeColor",
+          'rangeURI': "string"
+        },{
+          'name': "TubeType",
+          'rangeURI': "string"
+        },{
+          'name': "ProblemWithTube",
+          'rangeURI': "boolean"
+        },{
+          'name': "Comments",
+          'rangeURI': "string"
+        }]
+    }
+}
+
+# domain.create returns the full Domain definition
+created_sampleset_domain = domain.create(server_context, sampleset_domain_definition)
+
+###################
+# Get a domain
+###################
+sampleset_domain = domain.get(server_context, 'samples', 'BloodSamples')
+
+# examine different fields from the domain
+print(sampleset_domain.name)
+print(sampleset_domain.fields[0].name)
+
+###################
+# Save a domain
+###################
+sampleset_domain.add_field({
+    'name': 'canTransfuse',
+    'rangeURI': 'boolean'
+})
+
+# Use infer fields to define additional fields
+fields_file = open('data/infer.tsv', 'rb')
+inferred_fields = domain.infer_fields(server_context, fields_file)
+
+for field in inferred_fields:
+    sampleset_domain.add_field(field)
+
+domain.save(server_context, 'samples', 'BloodSamples', sampleset_domain)
+
+###################
+# Drop a domain
+###################
+
+drop_response = domain.drop(server_context, 'samples', 'BloodSamples')
+if 'success' in drop_response:
+    print('The SampleSet domain was deleted.')