diff --git a/internal/src/org/labkey/api/exp/property/AbstractDomainKind.java b/internal/src/org/labkey/api/exp/property/AbstractDomainKind.java
index 8c07baf0df9..02659446c3f 100644
--- a/internal/src/org/labkey/api/exp/property/AbstractDomainKind.java
+++ b/internal/src/org/labkey/api/exp/property/AbstractDomainKind.java
@@ -185,7 +185,7 @@ public boolean hasNullValues(Domain domain, DomainProperty prop)
         }
     }
 
-    private boolean getTotalAndNonBlankSql(Domain domain, DomainProperty prop, SQLFragment allRowsSQL, SQLFragment nonBlankRowsSQL)
+    protected boolean getTotalAndNonBlankSql(Domain domain, DomainProperty prop, SQLFragment allRowsSQL, SQLFragment nonBlankRowsSQL)
     {
         if (getStorageSchemaName() == null)
         {
diff --git a/internal/src/org/labkey/experiment/api/SampleTypeDomainKind.java b/internal/src/org/labkey/experiment/api/SampleTypeDomainKind.java
index 83a75fc7e37..f60facb5387 100644
--- a/internal/src/org/labkey/experiment/api/SampleTypeDomainKind.java
+++ b/internal/src/org/labkey/experiment/api/SampleTypeDomainKind.java
@@ -32,6 +32,7 @@
 import org.labkey.api.data.PropertyStorageSpec;
 import org.labkey.api.data.RuntimeSQLException;
 import org.labkey.api.data.SQLFragment;
+import org.labkey.api.data.SqlSelector;
 import org.labkey.api.data.TableInfo;
 import org.labkey.api.data.UpdateableTableInfo;
 import org.labkey.api.exp.ExperimentException;
@@ -44,6 +45,7 @@
 import org.labkey.api.exp.api.SampleTypeService;
 import org.labkey.api.exp.property.AbstractDomainKind;
 import org.labkey.api.exp.property.Domain;
+import org.labkey.api.exp.property.DomainProperty;
 import org.labkey.api.exp.query.ExpSampleTypeTable;
 import org.labkey.api.exp.query.SamplesSchema;
 import org.labkey.api.gwt.client.DefaultValueType;
@@ -517,4 +519,28 @@ public SampleTypeDomainKindProperties getDomainKindProperties(GWTDomain domain,
         ExpSampleType sampleType = domain != null ? SampleTypeService.get().getSampleType(domain.getDomainURI()) : null;
         return new SampleTypeDomainKindProperties(sampleType);
     }
+
+    @Override
+    public boolean hasNullValues(Domain domain, DomainProperty prop)
+    {
+        SQLFragment allRowsSQL = new SQLFragment();
+        SQLFragment nonBlankRowsSQL = new SQLFragment();
+
+        if (getTotalAndNonBlankSql(domain, prop, allRowsSQL, nonBlankRowsSQL))
+        {
+            // Issue 43754: Don't include aliquot rows in the null value check (see ExpMaterialTableImpl.createColumn for IsAliquot)
+            String table = domain.getStorageTableName();
+            SQLFragment nonAliquotRowsSQL = new SQLFragment("SELECT * FROM exp.material WHERE LSID IN (")
+                    .append("SELECT LSID FROM " + getStorageSchemaName() + "." + table)
+                    .append(") AND RootMaterialLSID IS NULL");
+
+            long totalRows = new SqlSelector(ExperimentService.get().getSchema(), nonAliquotRowsSQL).getRowCount();
+            long nonBlankRows = new SqlSelector(ExperimentService.get().getSchema(), nonBlankRowsSQL).getRowCount();
+            return totalRows != nonBlankRows;
+        }
+        else
+        {
+            return false;
+        }
+    }
 }