A popup with the close button makes the map ignore the second click.

[kvpster]

http://leafletjs.com/examples/quick-start-example.html

1. Press on the map - a popup appears.
2. Close the popup with the close button.
3. Press again on the map - nothing is happening.
4. Press second time - the popup appears.

[mourner]

Confirmed, will check this out — thanks.