diff --git a/asyncpg/connection.py b/asyncpg/connection.py
index e21c12c4..23141f4d 100644
--- a/asyncpg/connection.py
+++ b/asyncpg/connection.py
@@ -291,12 +291,20 @@ async def _get_statement(self, query, timeout, *, named: bool=False,
             types, intro_stmt = await self.__execute(
                 self._intro_query, (list(ready),), 0, timeout)
             self._protocol.get_settings().register_data_types(types)
-            if not intro_stmt.name and not statement.name:
-                # The introspection query has used an anonymous statement,
-                # which has blown away the anonymous statement we've prepared
-                # for the query, so we need to re-prepare it.
-                statement = await self._protocol.prepare(
-                    stmt_name, query, timeout)
+            # The introspection query has used an anonymous statement,
+            # which has blown away the anonymous statement we've prepared
+            # for the query, so we need to re-prepare it.
+            need_reprepare = not intro_stmt.name and not statement.name
+        else:
+            need_reprepare = False
+
+        # Now that types have been resolved, populate the codec pipeline
+        # for the statement.
+        statement._init_codecs()
+
+        if need_reprepare:
+            await self._protocol.prepare(
+                stmt_name, query, timeout, state=statement)
 
         if use_cache:
             self._stmt_cache.put(query, statement)
diff --git a/asyncpg/protocol/prepared_stmt.pxd b/asyncpg/protocol/prepared_stmt.pxd
index 8dab35b1..9749113c 100644
--- a/asyncpg/protocol/prepared_stmt.pxd
+++ b/asyncpg/protocol/prepared_stmt.pxd
@@ -30,6 +30,7 @@ cdef class PreparedStatementState:
         tuple        rows_codecs
 
     cdef _encode_bind_msg(self, args)
+    cpdef _init_codecs(self)
     cdef _ensure_rows_decoder(self)
     cdef _ensure_args_encoder(self)
     cdef _set_row_desc(self, object desc)
diff --git a/asyncpg/protocol/prepared_stmt.pyx b/asyncpg/protocol/prepared_stmt.pyx
index 3edb56f0..e69369d3 100644
--- a/asyncpg/protocol/prepared_stmt.pyx
+++ b/asyncpg/protocol/prepared_stmt.pyx
@@ -82,6 +82,10 @@ cdef class PreparedStatementState:
         else:
             return True
 
+    cpdef _init_codecs(self):
+        self._ensure_args_encoder()
+        self._ensure_rows_decoder()
+
     def attach(self):
         self.refs += 1
 
@@ -101,9 +105,6 @@ cdef class PreparedStatementState:
             raise exceptions.InterfaceError(
                 'the number of query arguments cannot exceed 32767')
 
-        self._ensure_args_encoder()
-        self._ensure_rows_decoder()
-
         writer = WriteBuffer.new()
 
         num_args_passed = len(args)
diff --git a/asyncpg/protocol/protocol.pyx b/asyncpg/protocol/protocol.pyx
index 09fc8c11..983c0ea1 100644
--- a/asyncpg/protocol/protocol.pyx
+++ b/asyncpg/protocol/protocol.pyx
@@ -146,7 +146,8 @@ cdef class BaseProtocol(CoreProtocol):
             self.is_reading = False
             self.transport.pause_reading()
 
-    async def prepare(self, stmt_name, query, timeout):
+    async def prepare(self, stmt_name, query, timeout,
+                      PreparedStatementState state=None):
         if self.cancel_waiter is not None:
             await self.cancel_waiter
         if self.cancel_sent_waiter is not None:
@@ -160,7 +161,9 @@ cdef class BaseProtocol(CoreProtocol):
         try:
             self._prepare(stmt_name, query)  # network op
             self.last_query = query
-            self.statement = PreparedStatementState(stmt_name, query, self)
+            if state is None:
+                state = PreparedStatementState(stmt_name, query, self)
+            self.statement = state
         except Exception as ex:
             waiter.set_exception(ex)
             self._coreproto_error()
diff --git a/tests/test_introspection.py b/tests/test_introspection.py
index d46095f8..fcf5885d 100644
--- a/tests/test_introspection.py
+++ b/tests/test_introspection.py
@@ -5,6 +5,8 @@
 # the Apache 2.0 License: http://www.apache.org/licenses/LICENSE-2.0
 
 
+import json
+
 from asyncpg import _testbase as tb
 from asyncpg import connection as apg_con
 
@@ -98,3 +100,28 @@ async def test_introspection_no_stmt_cache_03(self):
             "SELECT $1::int[], '{foo}'".format(foo='a' * 10000), [1, 2])
 
         self.assertEqual(apg_con._uid, old_uid + 1)
+
+    async def test_introspection_sticks_for_ps(self):
+        # Test that the introspected codec pipeline for a prepared
+        # statement is not affected by a subsequent codec cache bust.
+
+        ps = await self.con._prepare('SELECT $1::json[]', use_cache=True)
+
+        try:
+            # Setting a custom codec blows the codec cache for derived types.
+            await self.con.set_type_codec(
+                'json', encoder=lambda v: v, decoder=json.loads,
+                schema='pg_catalog', format='text'
+            )
+
+            # The originally prepared statement should still be OK and
+            # use the previously selected codec.
+            self.assertEqual(await ps.fetchval(['{"foo": 1}']), ['{"foo": 1}'])
+
+            # The new query uses the custom codec.
+            v = await self.con.fetchval('SELECT $1::json[]', ['{"foo": 1}'])
+            self.assertEqual(v, [{'foo': 1}])
+
+        finally:
+            await self.con.reset_type_codec(
+                'json', schema='pg_catalog')