diff --git a/lib/extensions/ar_adapter/ar_pglogical/pglogical_raw.rb b/lib/extensions/ar_adapter/ar_pglogical/pglogical_raw.rb
index ed0c7c16185..49a29c4e98b 100644
--- a/lib/extensions/ar_adapter/ar_pglogical/pglogical_raw.rb
+++ b/lib/extensions/ar_adapter/ar_pglogical/pglogical_raw.rb
@@ -302,6 +302,18 @@ def tables_in_replication_set(set_name)
     SQL
   end
 
+  def with_replication_set_lock(set_name)
+    connection.transaction(:requires_new => true) do
+      typed_exec(<<-SQL, set_name)
+        SELECT *
+        FROM pglogical.replication_set
+        WHERE set_name = $1
+        FOR UPDATE
+      SQL
+      yield
+    end
+  end
+
   private
 
   def typed_exec(sql, *params)
diff --git a/lib/miq_pglogical.rb b/lib/miq_pglogical.rb
index 97f635b4287..c2638313dc3 100644
--- a/lib/miq_pglogical.rb
+++ b/lib/miq_pglogical.rb
@@ -80,19 +80,17 @@ def create_replication_set
 
   # Aligns the contents of the 'miq' replication set with the currently configured vmdb excludes
   def refresh_excludes
-    # remove newly excluded tables from replication set
-    newly_excluded_tables.each do |table|
-      _log.info("Removing #{table} from #{REPLICATION_SET_NAME} replication set")
-      pglogical.replication_set_remove_table(REPLICATION_SET_NAME, table)
-    end
+    pglogical.with_replication_set_lock(REPLICATION_SET_NAME) do
+      # remove newly excluded tables from replication set
+      newly_excluded_tables.each do |table|
+        _log.info("Removing #{table} from #{REPLICATION_SET_NAME} replication set")
+        pglogical.replication_set_remove_table(REPLICATION_SET_NAME, table)
+      end
 
-    # add tables to the set which are no longer excluded (or new)
-    newly_included_tables.each do |table|
-      _log.info("Adding #{table} to #{REPLICATION_SET_NAME} replication set")
-      begin
+      # add tables to the set which are no longer excluded (or new)
+      newly_included_tables.each do |table|
+        _log.info("Adding #{table} to #{REPLICATION_SET_NAME} replication set")
         pglogical.replication_set_add_table(REPLICATION_SET_NAME, table, true)
-      rescue PG::UniqueViolation => e
-        _log.warn("Caught unique constraint error while adding #{table} to the replication set: #{e.message}")
       end
     end
   end
diff --git a/spec/replication/util/ar_pglogical_spec.rb b/spec/replication/util/ar_pglogical_spec.rb
index b35cfa42a56..4f227fb7510 100644
--- a/spec/replication/util/ar_pglogical_spec.rb
+++ b/spec/replication/util/ar_pglogical_spec.rb
@@ -226,6 +226,22 @@
             expect(connection.pglogical.tables_in_replication_set(set_name)).to eq(["test"])
           end
         end
+
+        describe "#with_replication_set_lock" do
+          it "takes a lock on the replication set table" do
+            connection.pglogical.with_replication_set_lock(set_name) do
+              result = connection.exec_query(<<-SQL)
+                SELECT 1
+                FROM pg_locks JOIN pg_class
+                  ON pg_locks.relation = pg_class.oid
+                WHERE
+                  pg_class.relname = 'replication_set' AND
+                  pg_locks.mode = 'RowShareLock'
+              SQL
+              expect(result.count).to eq(1)
+            end
+          end
+        end
       end
     end
   end
diff --git a/spec/replication/util/miq_pglogical_spec.rb b/spec/replication/util/miq_pglogical_spec.rb
index 4a94bc1d127..df4e9bea36c 100644
--- a/spec/replication/util/miq_pglogical_spec.rb
+++ b/spec/replication/util/miq_pglogical_spec.rb
@@ -100,11 +100,6 @@
         subject.refresh_excludes
         expect(subject.included_tables).to include(table)
       end
-
-      it "continues if we attempt to add a table twice" do
-        expect(subject).to receive(:newly_included_tables).and_return([subject.included_tables.first])
-        expect { subject.refresh_excludes }.not_to raise_error
-      end
     end
   end