[FILEINFO] file = 'theophylline_data.txt' delimiter = tab header = {ID, AMT, AMT_KG, TIME, CONC, WEIGHT, SEX} [CONTENT] ID = {use=identifier} AMT = {use=amount} TIME = {use=time} CONC = {use=observation, name=CONC, type=continuous} WEIGHT = {use=covariate, type=continuous} [INDIVIDUAL] input = {Cl_pop, omega_Cl, V_pop, omega_V, ka_pop, omega_ka} DEFINITION: Cl = {distribution=logNormal, typical=Cl_pop, sd=omega_Cl} V = {distribution=logNormal, typical=V_pop, sd=omega_V} ka = {distribution=logNormal, typical=ka_pop, sd=omega_ka} [LONGITUDINAL] input = {b} file = 'theophylline_mlxt.txt' DEFINITION: CONC = {distribution=normal, prediction=Cc, errorModel=proportional(b)} data = CONC model = CONC Cl_pop = {value=1, method=MLE} V_pop = {value=20, method=MLE} b = {value=0.3, method=MLE} ka_pop = {value=1, method=MLE} omega_Cl = {value=1, method=MLE} omega_V = {value=1, method=MLE} omega_ka = {value=1, method=MLE} [TASKS] populationParameters() individualParameters(method = {conditionalMean, conditionalMode }) fim(run = false,method = StochasticApproximation) logLikelihood(run = false,method = ImportanceSampling) plotResult(method = {outputplot, indfits, obspred, parameterdistribution, covariatemodeldiagnosis, randomeffects, covariancemodeldiagnosis, residualsscatter, residualsdistribution, saemresults }) [SETTINGS] GLOBAL: exportpath = 'theophylline_project2019' [COMMENTS] ; Including a comment prevents monolix2simulx() from working (mlxR 4.0.0)