diff --git a/components/select/select.component.ts b/components/select/select.component.ts
index 0e04ff49933..cfbece51342 100644
--- a/components/select/select.component.ts
+++ b/components/select/select.component.ts
@@ -115,6 +115,7 @@ export type NzSelectSizeType = 'large' | 'default' | 'small';
       [cdkConnectedOverlayTransformOriginOn]="'.ant-select-dropdown'"
       [cdkConnectedOverlayPanelClass]="nzDropdownClassName!"
       [cdkConnectedOverlayOpen]="nzOpen"
+      (overlayKeydown)="onOverlayKeyDown($event)"
       (overlayOutsideClick)="onClickOutside($event)"
       (detach)="setOpenState(false)"
       (positionChange)="onPositionChange($event)"
@@ -368,6 +369,12 @@ export class NzSelectComponent implements ControlValueAccessor, OnInit, AfterVie
     this.clearInput();
   }
 
+  onOverlayKeyDown(e: KeyboardEvent): void {
+    if (e.keyCode === ESCAPE) {
+      this.setOpenState(false);
+    }
+  }
+
   onKeyDown(e: KeyboardEvent): void {
     if (this.nzDisabled) {
       return;
@@ -411,7 +418,9 @@ export class NzSelectComponent implements ControlValueAccessor, OnInit, AfterVie
         this.setOpenState(false);
         break;
       case ESCAPE:
-        this.setOpenState(false);
+        /**
+         * Skip the ESCAPE processing, it will be handled in {@link onOverlayKeyDown}.
+         */
         break;
       default:
         if (!this.nzOpen) {
diff --git a/components/select/select.spec.ts b/components/select/select.spec.ts
index 1912567de1c..27d5bd18699 100644
--- a/components/select/select.spec.ts
+++ b/components/select/select.spec.ts
@@ -1,6 +1,7 @@
-import { BACKSPACE, DOWN_ARROW, ENTER, SPACE, TAB, UP_ARROW } from '@angular/cdk/keycodes';
+import { BACKSPACE, DOWN_ARROW, ENTER, ESCAPE, SPACE, TAB, UP_ARROW } from '@angular/cdk/keycodes';
+import { OverlayContainer } from '@angular/cdk/overlay';
 import { Component, TemplateRef, ViewChild } from '@angular/core';
-import { ComponentFixture, fakeAsync, flush } from '@angular/core/testing';
+import { ComponentFixture, fakeAsync, flush, inject } from '@angular/core/testing';
 import { FormsModule } from '@angular/forms';
 import { By } from '@angular/platform-browser';
 import {
@@ -22,12 +23,19 @@ describe('select', () => {
     let component: TestSelectTemplateDefaultComponent;
     let fixture: ComponentFixture<TestSelectTemplateDefaultComponent>;
     let selectElement!: HTMLElement;
+    let overlayContainerElement: HTMLElement;
+
     beforeEach(() => {
       testBed = createComponentBed(TestSelectTemplateDefaultComponent, { imports: [NzSelectModule, NzIconTestModule, FormsModule] });
       component = testBed.component;
       fixture = testBed.fixture;
       selectElement = testBed.debugElement.query(By.directive(NzSelectComponent)).nativeElement;
     });
+
+    beforeEach(inject([OverlayContainer], (oc: OverlayContainer) => {
+      overlayContainerElement = oc.getContainerElement();
+    }));
+
     it('should classname correct', () => {
       expect(selectElement.classList).toContain('ant-select');
       expect(selectElement.classList).toContain('ant-select-single');
@@ -255,6 +263,22 @@ describe('select', () => {
       expect(selectElement.classList).toContain('ant-select-disabled');
       expect(selectElement.querySelector('input')!.getAttribute('disabled')).toBe('');
     }));
+
+    it('should close dropdown when ESC keydown', fakeAsync(() => {
+      component.nzOpen = true;
+      fixture.detectChanges();
+      flush();
+      fixture.detectChanges();
+
+      dispatchKeyboardEvent(overlayContainerElement, 'keydown', ESCAPE, overlayContainerElement);
+
+      fixture.detectChanges();
+      flush();
+      fixture.detectChanges();
+
+      expect(component.nzOpen).toBe(false);
+    }));
+
     it('should keydown up arrow and down arrow', fakeAsync(() => {
       const flushChanges = () => {
         fixture.detectChanges();