diff --git a/CHANGELOG.md b/CHANGELOG.md
index 24e904ba..bf47702e 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -3,6 +3,7 @@
 ## [Unreleased]
 
 ### Added
+* Make project setup guidelines optional [553](https://github.com/NLeSC/python-template/pull/553)
 * Make contributing guidelines optional [#465]()
 * Make developer documentation optional [#467](https://github.com/NLeSC/python-template/pull/541)
 * Make Code of Conduct optional [#464](https://github.com/NLeSC/python-template/pull/530)
diff --git a/copier/questions/features.yml b/copier/questions/features.yml
index c5c6e185..f193e72d 100644
--- a/copier/questions/features.yml
+++ b/copier/questions/features.yml
@@ -60,3 +60,8 @@ AddDevDoc:
   type: bool
   default: "{{ template_profile != 'minimum' }}"
   help: Add developer documentation?
+AddProjectSetup:
+  when: "{{ template_profile == 'ask' }}"
+  type: bool
+  default: "{{ template_profile != 'minimum' }}"
+  help: Add a document to describe project setup?
diff --git a/template/README.md.jinja b/template/README.md.jinja
index 8523375a..d165c82c 100644
--- a/template/README.md.jinja
+++ b/template/README.md.jinja
@@ -30,11 +30,13 @@
 | Link checker              | [![link-check]({{repository_url}}/actions/workflows/link-check.yml/badge.svg)]({{repository_url}}/actions/workflows/link-check.yml) |
 {%- endif -%}
 
+{% if AddProjectSetup -%}
 ## How to use {{ package_name }}
 
 {{ package_short_description|replace('\"', '\\\"') }}
 
 The project setup is documented in [project_setup.md](project_setup.md). Feel free to remove this document (and/or the link to this document) if you don't need it.
+{%- endif %}
 
 ## Installation
 
diff --git a/template/project_setup.md.jinja b/template/{% if AddProjectSetup %}project_setup.md{% endif %}.jinja
similarity index 100%
rename from template/project_setup.md.jinja
rename to template/{% if AddProjectSetup %}project_setup.md{% endif %}.jinja