diff --git a/pkgs/development/python-modules/graph-tool/2.x.x.nix b/pkgs/development/python-modules/graph-tool/2.x.x.nix
index 4f39d1097b1c2c..f28e902ca0f14e 100644
--- a/pkgs/development/python-modules/graph-tool/2.x.x.nix
+++ b/pkgs/development/python-modules/graph-tool/2.x.x.nix
@@ -12,6 +12,7 @@ stdenv.mkDerivation rec {
     license     = licenses.gpl3;
     platforms   = platforms.all;
     maintainer  = [ stdenv.lib.maintainers.joelmo ];
+    broken = true;
   };
 
   src = fetchurl {
diff --git a/pkgs/development/python-modules/libagent/default.nix b/pkgs/development/python-modules/libagent/default.nix
index 5318142fe706fa..e26a0ed6e44cd8 100644
--- a/pkgs/development/python-modules/libagent/default.nix
+++ b/pkgs/development/python-modules/libagent/default.nix
@@ -22,5 +22,6 @@ buildPythonPackage rec {
     homepage = https://github.com/romanz/trezor-agent;
     license = licenses.gpl3;
     maintainers = with maintainers; [ np ];
+    broken = true;
   };
 }
diff --git a/pkgs/development/python-modules/ltc_scrypt/default.nix b/pkgs/development/python-modules/ltc_scrypt/default.nix
index 273571c66e1f3e..779db17c5c12ee 100644
--- a/pkgs/development/python-modules/ltc_scrypt/default.nix
+++ b/pkgs/development/python-modules/ltc_scrypt/default.nix
@@ -1,6 +1,7 @@
 { stdenv
 , buildPythonPackage
 , fetchPypi
+, isPy3k
 }:
 
 buildPythonPackage rec {
@@ -13,6 +14,8 @@ buildPythonPackage rec {
     sha256 = "1h90hh3iw4i7zs7jgskdjlk8gi97b3v2zqsxdfwdvhrrnhpvv856";
   };
 
+  disabled = isPy3k;
+
   meta = with stdenv.lib; {
     description = "Bindings for scrypt proof of work used by Litecoin";
     homepage = https://pypi.python.org/pypi/ltc_scrypt;
diff --git a/pkgs/development/python-modules/marionette-harness/default.nix b/pkgs/development/python-modules/marionette-harness/default.nix
index fbdd13a7f385fb..d491b6c0153d59 100644
--- a/pkgs/development/python-modules/marionette-harness/default.nix
+++ b/pkgs/development/python-modules/marionette-harness/default.nix
@@ -31,5 +31,6 @@ buildPythonPackage rec {
     homepage = https://developer.mozilla.org/en-US/docs/Mozilla/QA/Marionette;
     license = lib.licenses.mpl20;
     maintainers = with lib.maintainers; [ raskin ];
+    broken = true;
   };
 }
diff --git a/pkgs/development/python-modules/xarray/default.nix b/pkgs/development/python-modules/xarray/default.nix
index 7b9712dfd02396..f63eaf0bfb737f 100644
--- a/pkgs/development/python-modules/xarray/default.nix
+++ b/pkgs/development/python-modules/xarray/default.nix
@@ -29,5 +29,6 @@ buildPythonPackage rec {
     homepage = https://github.com/pydata/xarray;
     license = lib.licenses.asl20;
     maintainers = with lib.maintainers; [ fridh ];
+    broken = true;
   };
 }
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 4b3ffcdf7e596a..058c9e4740b6c6 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -1824,6 +1824,8 @@ in {
       sha256 = "496265f4b7d33483ec153b9e1b8333fe959b115f7e781510089c8313b7d86560";
     };
 
+    disabled = isPy3k;
+
     meta = {
       description = "Tap into The Echo Nest's Musical Brain for the best music search, information, recommendations and remix tools on the web";
       homepage = https://github.com/echonest/pyechonest;
@@ -3310,6 +3312,8 @@ in {
       bandit oslosphinx coverage testtools testscenarios testrepository mock
 
     ];
+
+    meta.broken = true;
   };
 
   barbicanclient = buildPythonPackage rec {
@@ -3389,6 +3393,7 @@ in {
       description = "Client library and command line tool for the OpenStack Nova API";
       license = stdenv.lib.licenses.asl20;
       platforms = stdenv.lib.platforms.linux;
+      broken = true;
     };
   };
 
@@ -3403,6 +3408,8 @@ in {
 
     buildInputs = with self; [ pytest ];
 
+    disabled = isPy3k;
+
     meta = with stdenv.lib; {
       description = "Tablib: format-agnostic tabular dataset library";
       homepage = "http://python-tablib.org";
@@ -5428,6 +5435,7 @@ in {
     propagatedBuildInputs = with self; [ python_fedora pyopenssl ];
     postInstall = "mv $out/bin/fedpkg $out/bin/fedora-cert-fedpkg";
     doCheck = false;
+    disabled = isPy3k;
   };
 
   fedpkg = buildPythonPackage (rec {
@@ -6274,6 +6282,8 @@ in {
     buildInputs = with self; [ pytest ];
     propagatedBuildInputs = with self; [ six clint pyyaml docopt requests jsonpatch args ];
 
+    disabled = isPy3k;
+
     meta = with stdenv.lib; {
       description = "A python wrapper for the various Internet Archive APIs";
       homepage = "https://github.com/jjjake/internetarchive";
@@ -6443,6 +6453,7 @@ in {
 
     buildInputs = [ pkgs.bluez pkgs.openobex ];
 
+    disabled = isPy3k;
 
     meta = {
       homepage = http://lightblue.sourceforge.net;
@@ -6769,7 +6780,9 @@ in {
       url = git://github.com/etsy/logster;
       rev = "7475c53822";
       sha256 = "0565wxxiwksnly8rakb2r77k7lwzniq16kv861qd2ns9hgsjgy31";
-    };
+     };
+
+     disabled = isPy3k;
   };
 
   logfury = callPackage ../development/python-modules/logfury { };
@@ -7725,6 +7738,8 @@ in {
 
     buildInputs = with self; [ zope_interface zope_location zope_schema ];
 
+    disabled = isPy3k;
+
     meta = {
       maintainers = with maintainers; [ domenkozar ];
     };
@@ -10210,6 +10225,8 @@ in {
     };
 
     propagatedBuildInputs = with self; [ requests ];
+
+    disabled = isPy3k;
   };
 
   hypothesis = callPackage ../development/python-modules/hypothesis.nix { };
@@ -11283,6 +11300,7 @@ in {
     meta = {
       homepage = http://locust.io/;
       description = "A load testing tool";
+      broken = true;
     };
   };
 
@@ -13083,6 +13101,8 @@ in {
 
     propagatedBuildInputs = with self; [ nose ];
 
+    disabled = isPy3k;
+
     meta = {
       description = "Simple nose plugin that enables developers to run subset of collected tests to spare some waiting time for better things";
     };
@@ -14092,6 +14112,8 @@ in {
     patchPhase = ''
       sed -i 's@python@${python.interpreter}@' .testr.conf
     '';
+
+    meta.broken = true;
   };
 
   cinderclient = buildPythonPackage rec {
@@ -14211,6 +14233,7 @@ in {
     buildInputs = with self; [
       tempest-lib testresources mock oslotest
     ];
+    meta.broken = true;
   };
 
   oslo-rootwrap = buildPythonPackage rec {
@@ -14457,6 +14480,8 @@ in {
       sed -i '/doc8/d' test-requirements.txt
       ${python.interpreter} setup.py test
     '';
+
+    meta.broken = true;
   };
 
   glance_store = buildPythonPackage rec {
@@ -14608,6 +14633,8 @@ in {
       # https://github.com/openstack/networking-hyperv/commit/56d66fc012846620a60cb8f18df5a1c889fe0e26
       sed -i 's/from oslo import i18n/import oslo_i18n as i18n/' hyperv/common/i18n.py
     '';
+
+    broken = true;
   };
 
   kazoo = buildPythonPackage rec {
@@ -15370,6 +15397,8 @@ in {
 
     propagatedBuildInputs = with self; [ httplib2 ];
 
+    disabled = isPy3k;
+
     meta = {
       homepage = https://developer.paypal.com/;
       description = "Python APIs to create, process and manage payment";
@@ -16104,7 +16133,7 @@ in {
 
 
   pyalgotrade = buildPythonPackage {
-    name = "pyalogotrade-0.16";
+    name = "pyalgotrade-0.16";
 
     src = pkgs.fetchurl {
       url = "mirror://pypi/P/PyAlgoTrade/PyAlgoTrade-0.16.tar.gz";
@@ -16113,6 +16142,8 @@ in {
 
     propagatedBuildInputs = with self; [ numpy scipy pytz ];
 
+    disable = isPy3k;
+
     meta = {
       description = "Python Algorithmic Trading";
       homepage = http://gbeced.github.io/pyalgotrade/;
@@ -16435,6 +16466,7 @@ in {
     meta = {
       description = "Interface for working with block devices";
       license = licenses.gpl2Plus;
+      broken = isPy3k;
     };
   };
 
@@ -16497,6 +16529,7 @@ in {
       license = licenses.bsd2;
       platforms = platforms.all;
       homepage = "http://jparyani.github.io/pycapnp/index.html";
+      broken = true;
     };
   };
 
@@ -19495,6 +19528,8 @@ in {
       sha256 = "1b59vyy12g6rix9l2fxx0hjiq33shkb79v57gwffs57vh74wc53v";
     };
 
+    disabled = isPy3k;
+
     meta = {
       description = "A Python object API for managing the Linux LIO kernel target";
       homepage = "https://github.com/agrover/rtslib-fb";
@@ -21809,6 +21844,8 @@ in {
       sha256 = "64a6c3f1a60a9d8bf18f96a5403f3735b334040345ac3646064931c209720972";
     };
 
+    disabled = isPy3k;
+
     meta = {
       description = "Python implementation of the v3 API for TheMovieDB.org, allowing access to movie and cast information";
       homepage = http://pypi.python.org/pypi/tmdb3;
@@ -22506,6 +22543,8 @@ in {
       sha256 = "aa6aef08995e14c20cc670d933bfa6e70d736d0b555af309b2e989e2faa9ee53";
     };
 
+    disabled = isPy3k;
+
     meta = {
       description = "Python wrapper for Xvfb, Xephyr and Xvnc";
       homepage = "https://github.com/ponty/pyvirtualdisplay";
@@ -23514,6 +23553,8 @@ EOF
 
     buildInputs = with self; [ mock nose ];
 
+    disabled = isPy3k;
+
     meta = {
       description = "Python API for the browse feature of Spotify";
       homepage = https://github.com/trygveaa/python-tunigo;
@@ -24513,6 +24554,8 @@ EOF
     };
 
     propagatedBuildInputs = with self; [requests websocket_client python_magic ];
+
+    meta.broken = true;
   };
 
   power = buildPythonPackage rec {
@@ -24828,6 +24871,8 @@ EOF
     };
 
     propagatedBuildInputs = with self; [ pynacl six ];
+
+    disabled = isPy3k;
   };
 
   pynacl = buildPythonPackage rec {
@@ -26858,6 +26903,8 @@ EOF
     };
     propagatedBuildInputs = with self; [ requests ];
 
+    disabled = isPy3k;
+
     meta = {
       description = "A Python client for the Packet API.";
       homepage    = "https://github.com/packethost/packet-python";
@@ -26962,6 +27009,8 @@ EOF
       rev = "479211f6c5a7d034fd77762dfed381c3315cd773";
       sha256 = "1ad0mkixc0s86djwsvhp1qlvcfs25086nh0qw7bys49gz8shczzi";
     };
+
+    disabled = isPy3k;
   };
 
   wptserve = callPackage ../development/python-modules/wptserve { };