diff --git a/pkgs/development/libraries/audio/rtaudio/default.nix b/pkgs/development/libraries/audio/rtaudio/default.nix
index 820ea1e49b9ef8..03048abcc3212f 100644
--- a/pkgs/development/libraries/audio/rtaudio/default.nix
+++ b/pkgs/development/libraries/audio/rtaudio/default.nix
@@ -1,4 +1,19 @@
-{ lib, stdenv, fetchFromGitHub, autoconf, automake, libtool, libjack2,  alsaLib, pulseaudio, rtmidi }:
+{ stdenv
+, lib
+, config
+, fetchFromGitHub
+, fetchpatch
+, cmake
+, pkg-config
+, alsaSupport ? stdenv.hostPlatform.isLinux
+, alsaLib
+, pulseaudioSupport ? config.pulseaudio or stdenv.hostPlatform.isLinux
+, libpulseaudio
+, jackSupport ? true
+, jack
+, coreaudioSupport ? stdenv.hostPlatform.isDarwin
+, CoreAudio
+}:
 
 stdenv.mkDerivation rec {
   version = "5.1.0";
@@ -11,22 +26,40 @@ stdenv.mkDerivation rec {
     sha256 = "1pglnjz907ajlhnlnig3p0sx7hdkpggr8ss7b3wzf1lykzgv9l52";
   };
 
-  patches = [ ./rtaudio-pkgconfig.patch ];
+  patches = [
+    # Fixes missing headers & install location
+    # Drop with version > 5.1.0
+    (fetchpatch {
+      name = "RtAudio-Adjust-CMake-public-header-installs-to-match-autotools.patch";
+      url = "https://github.com/thestk/rtaudio/commit/4273cf7572b8f51b5996cf6b42e3699cc6b165da.patch";
+      sha256 = "1p0idll0xsfk3jwjg83jkxkaf20gk0wqa7l982ni389rn6i4n26p";
+    })
+  ];
 
-  enableParallelBuilding = true;
+  postPatch = ''
+    substituteInPlace rtaudio.pc.in \
+      --replace 'Requires:' 'Requires.private:'
+  '';
 
-  buildInputs = [ autoconf automake libtool libjack2 alsaLib pulseaudio rtmidi ];
+  nativeBuildInputs = [ cmake pkg-config ];
 
-  preConfigure = ''
-    ./autogen.sh --no-configure
-    ./configure
-  '';
+  buildInputs = lib.optional alsaSupport alsaLib
+    ++ lib.optional pulseaudioSupport libpulseaudio
+    ++ lib.optional jackSupport jack
+    ++ lib.optional coreaudioSupport CoreAudio;
+
+  cmakeFlags = [
+    "-DRTAUDIO_API_ALSA=${if alsaSupport then "ON" else "OFF"}"
+    "-DRTAUDIO_API_PULSE=${if pulseaudioSupport then "ON" else "OFF"}"
+    "-DRTAUDIO_API_JACK=${if jackSupport then "ON" else "OFF"}"
+    "-DRTAUDIO_API_CORE=${if coreaudioSupport then "ON" else "OFF"}"
+  ];
 
   meta = with lib; {
     description = "A set of C++ classes that provide a cross platform API for realtime audio input/output";
-    homepage =  "http://www.music.mcgill.ca/~gary/rtaudio/";
+    homepage = "https://www.music.mcgill.ca/~gary/rtaudio/";
     license = licenses.mit;
-    maintainers = [ maintainers.magnetophon ];
+    maintainers = with maintainers; [ magnetophon ];
     platforms = platforms.unix;
   };
 }
diff --git a/pkgs/development/libraries/audio/rtaudio/rtaudio-pkgconfig.patch b/pkgs/development/libraries/audio/rtaudio/rtaudio-pkgconfig.patch
deleted file mode 100644
index 8536332d46d796..00000000000000
--- a/pkgs/development/libraries/audio/rtaudio/rtaudio-pkgconfig.patch
+++ /dev/null
@@ -1,5 +0,0 @@
---- a/rtaudio.pc.in
-+++ b/rtaudio.pc.in
-@@ -9 +9 @@ Version: @PACKAGE_VERSION@
--Requires: @req@ 
-+Requires.private: @req@ 
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index 2fbf8a484d69c7..d9d6901950ea4c 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -7277,7 +7277,10 @@ in
 
   rocket = libsForQt5.callPackage ../tools/graphics/rocket { };
 
-  rtaudio = callPackage ../development/libraries/audio/rtaudio { };
+  rtaudio = callPackage ../development/libraries/audio/rtaudio {
+    jack = libjack2;
+    inherit (darwin.apple_sdk.frameworks) CoreAudio;
+  };
 
   rtmidi = callPackage ../development/libraries/audio/rtmidi {
     jack = libjack2;