diff --git a/pkgs/development/python-modules/opcodes/default.nix b/pkgs/development/python-modules/opcodes/default.nix
deleted file mode 100644
index 7b82bed8298bfaf..000000000000000
--- a/pkgs/development/python-modules/opcodes/default.nix
+++ /dev/null
@@ -1,32 +0,0 @@
-{
-  buildPythonPackage,
-  fetchFromGitHub,
-  lib,
-  # nativeCheckInputs
-  nose,
-}:
-buildPythonPackage {
-  strictDeps = true;
-  pname = "Opcodes";
-  version = "0.3.14";
-  format = "setuptools";
-  src = fetchFromGitHub {
-    owner = "Maratyszcza";
-    repo = "Opcodes";
-    rev = "b740e24c551a640e8ba4038101027aeffa0e6ee9";
-    hash = "sha256-vufeYnw9DOzCYu4tkbtkFvFZMQLhN1aOiZ2dr/6ECgU=";
-  };
-  doCheck = true;
-  nativeCheckInputs = [nose];
-  preCheck = ''
-    nosetests
-  '';
-  pythonImportsCheck = ["opcodes"];
-  meta = with lib; {
-    description = "Database of CPU Opcodes";
-    homepage = "https://github.com/Maratyszcza/Opcodes";
-    license = licenses.bsd2;
-    maintainers = with maintainers; [connorbaker];
-    platforms = platforms.all;
-  };
-}
diff --git a/pkgs/development/python-modules/peachpy/default.nix b/pkgs/development/python-modules/peachpy/default.nix
deleted file mode 100644
index 22c8468ad694d53..000000000000000
--- a/pkgs/development/python-modules/peachpy/default.nix
+++ /dev/null
@@ -1,51 +0,0 @@
-{
-  buildPythonPackage,
-  fetchFromGitHub,
-  lib,
-  # nativeBuildInputs
-  opcodes,
-  # propagatedBuildInputs
-  six,
-  # nativeCheckInputs
-  pytestCheckHook,
-}:
-buildPythonPackage {
-  strictDeps = true;
-  pname = "PeachPy";
-  version = "0.2.0";
-  format = "setuptools";
-  src = fetchFromGitHub {
-    owner = "Maratyszcza";
-    repo = "PeachPy";
-    rev = "349e8f836142b2ed0efeb6bb99b1b715d87202e9";
-    hash = "sha256-cX3+zigSTEnWEtuwspy7pQ3yKc8eeqD5uodJXOGb9po=";
-  };
-  nativeBuildInputs = [opcodes];
-  propagatedBuildInputs = [six];
-  doCheck = true;
-  nativeCheckInputs = [pytestCheckHook];
-  # TODO(@connorbaker):
-  #   - Do the ARM tests work on ARM?
-  #   - Do the x86 tests work on ARM?
-  disabledTests = [
-    "TestARM"
-  ];
-  pythonImportsCheck = [
-    "peachpy.arm"
-    "peachpy.c"
-    "peachpy.common"
-    "peachpy.formats.elf"
-    "peachpy.formats.macho"
-    "peachpy.formats.mscoff"
-    "peachpy.formats"
-    "peachpy.x86_64"
-    "peachpy"
-  ];
-  meta = with lib; {
-    description = "Portable Efficient Assembly Codegen in Higher-level Python";
-    homepage = "https://github.com/Maratyszcza/PeachPy";
-    license = licenses.bsd2;
-    maintainers = with maintainers; [connorbaker];
-    platforms = platforms.all;
-  };
-}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 472cd8bb0e35a41..6df7c8b16581b7d 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -7056,8 +7056,6 @@ self: super: with self; {
 
   oocsi = callPackage ../development/python-modules/oocsi { };
 
-  opcodes = callPackage ../development/python-modules/opcodes { };
-
   opcua-widgets = callPackage ../development/python-modules/opcua-widgets { };
 
   open-garage = callPackage ../development/python-modules/open-garage { };
@@ -7466,8 +7464,6 @@ self: super: with self; {
 
   peaqevcore = callPackage ../development/python-modules/peaqevcore { };
 
-  peachpy = callPackage ../development/python-modules/peachpy { };
-
   pegen = callPackage ../development/python-modules/pegen { };
 
   pebble = callPackage ../development/python-modules/pebble { };