diff --git a/pkgs/applications/virtualization/virtualbox/default.nix b/pkgs/applications/virtualization/virtualbox/default.nix
index ef834897022d4e..64275448651cd1 100644
--- a/pkgs/applications/virtualization/virtualbox/default.nix
+++ b/pkgs/applications/virtualization/virtualbox/default.nix
@@ -81,7 +81,7 @@ in stdenv.mkDerivation {
   '';
 
   patches = optional enableHardening ./hardened.patch
-    ++ [ ./libressl.patch ./qtx11extras.patch ];
+    ++ [ ./qtx11extras.patch ];
 
   postPatch = ''
     sed -i -e 's|/sbin/ifconfig|${nettools}/bin/ifconfig|' \
diff --git a/pkgs/applications/virtualization/virtualbox/libressl.patch b/pkgs/applications/virtualization/virtualbox/libressl.patch
deleted file mode 100644
index db9b7e7a59d95c..00000000000000
--- a/pkgs/applications/virtualization/virtualbox/libressl.patch
+++ /dev/null
@@ -1,47 +0,0 @@
-diff --git a/src/VBox/Runtime/common/crypto/digest-builtin.cpp b/src/VBox/Runtime/common/crypto/digest-builtin.cpp
-index 66b4304..1aaceff 100644
---- a/src/VBox/Runtime/common/crypto/digest-builtin.cpp
-+++ b/src/VBox/Runtime/common/crypto/digest-builtin.cpp
-@@ -561,7 +561,7 @@ static PCRTCRDIGESTDESC const g_apDigestOps[] =
-  * OpenSSL EVP.
-  */
- 
--# if OPENSSL_VERSION_NUMBER >= 0x10100000
-+# if OPENSSL_VERSION_NUMBER >= 0x10100000 && !defined(LIBRESSL_VERSION_NUMBER)
- /** @impl_interface_method{RTCRDIGESTDESC::pfnNew} */
- static DECLCALLBACK(void*) rtCrDigestOsslEvp_New(void)
- {
-@@ -597,7 +597,7 @@ static DECLCALLBACK(int) rtCrDigestOsslEvp_Init(void *pvState, void *pvOpaque, b
-     if (fReInit)
-     {
-         pEvpType = EVP_MD_CTX_md(pThis);
--# if OPENSSL_VERSION_NUMBER >= 0x10100000
-+# if OPENSSL_VERSION_NUMBER >= 0x10100000 && !defined(LIBRESSL_VERSION_NUMBER)
-         EVP_MD_CTX_reset(pThis);
- # else
-         EVP_MD_CTX_cleanup(pThis);
-@@ -616,7 +616,7 @@ static DECLCALLBACK(int) rtCrDigestOsslEvp_Init(void *pvState, void *pvOpaque, b
- static DECLCALLBACK(void) rtCrDigestOsslEvp_Delete(void *pvState)
- {
-     EVP_MD_CTX *pThis = (EVP_MD_CTX *)pvState;
--# if OPENSSL_VERSION_NUMBER >= 0x10100000
-+# if OPENSSL_VERSION_NUMBER >= 0x10100000 && !defined(LIBRESSL_VERSION_NUMBER)
-     EVP_MD_CTX_reset(pThis);
- # else
-     EVP_MD_CTX_cleanup(pThis);
-@@ -661,13 +661,13 @@ static RTCRDIGESTDESC const g_rtCrDigestOpenSslDesc =
-     NULL,
-     RTDIGESTTYPE_UNKNOWN,
-     EVP_MAX_MD_SIZE,
--# if OPENSSL_VERSION_NUMBER >= 0x10100000
-+# if OPENSSL_VERSION_NUMBER >= 0x10100000 && !defined(LIBRESSL_VERSION_NUMBER)
-     0,
- # else
-     sizeof(EVP_MD_CTX),
- # endif
-     0,
--# if OPENSSL_VERSION_NUMBER >= 0x10100000
-+# if OPENSSL_VERSION_NUMBER >= 0x10100000 && !defined(LIBRESSL_VERSION_NUMBER)
-     rtCrDigestOsslEvp_New,
-     rtCrDigestOsslEvp_Free,
- # else
diff --git a/pkgs/applications/virtualization/virtualbox/upstream-info.json b/pkgs/applications/virtualization/virtualbox/upstream-info.json
index 3a386004a3fd0b..d861a7e79324fc 100644
--- a/pkgs/applications/virtualization/virtualbox/upstream-info.json
+++ b/pkgs/applications/virtualization/virtualbox/upstream-info.json
@@ -1,8 +1,8 @@
 {
   "__NOTE": "Generated using update.py from the same directory.",
-  "extpack": "607ac3636bd49a738d5c48159b39261369b5487f71fb10afa2ecf869627a12de",
-  "extpackRev": "110634",
-  "guest": "cbcf9b9b1000e09911b3d20e1efe529aef8a945cf130f6abffc14a39522cc1ed",
-  "main": "2e0112b0d85841587b8f212e6ba8f6c35b31e1cce6b6999497dc917cd37e6911",
-  "version": "5.1.6"
+  "extpack": "d28bcd01c14eb07eedd2b964d1abe4876f0a7e0e89530e7ba285a5d6267bf322",
+  "extpackRev": "111374",
+  "guest": "347fd39df6ddee8079ad41fbc038e2fb64952a40255d75292e8e49a0a0cbf657",
+  "main": "e447031de468aee746529b2cf60768922f9beff22a13c54284aa430f5e925933",
+  "version": "5.1.8"
 }