diff --git a/pkgs/applications/backup/deja-dup/default.nix b/pkgs/applications/backup/deja-dup/default.nix
index d283dc7107d746..5d1d75e31ebcf8 100644
--- a/pkgs/applications/backup/deja-dup/default.nix
+++ b/pkgs/applications/backup/deja-dup/default.nix
@@ -3,44 +3,32 @@
 , substituteAll
 , meson
 , ninja
-, pkgconfig
+, pkg-config
 , vala
 , gettext
-, gnome3
-, libnotify
 , itstool
 , glib
 , gtk3
-, libxml2
-, gnome-online-accounts
 , coreutils
 , libsoup
 , libsecret
-, pcre
-, libxkbcommon
+, libhandy
 , wrapGAppsHook
-, libpthreadstubs
-, libXdmcp
-, epoxy
-, at-spi2-core
-, dbus
 , libgpgerror
 , json-glib
-, appstream-glib
-, desktop-file-utils
 , duplicity
 }:
 
 stdenv.mkDerivation rec {
   pname = "deja-dup";
-  version = "40.6";
+  version = "42.4";
 
   src = fetchFromGitLab {
     domain = "gitlab.gnome.org";
     owner = "World";
     repo = pname;
     rev = version;
-    sha256 = "1d4g34g660wv42a4k2511bxrh90z0vdl3v7ahg0m45phijg9n2n1";
+    sha256 = "c4E6mHYVb8TWVTVlmHidcLa9ebHJ27iStsNNLJhY8vY=";
   };
 
   patches = [
@@ -48,54 +36,31 @@ stdenv.mkDerivation rec {
       src = ./fix-paths.patch;
       inherit coreutils;
     })
-
-    # Hardcode GSettings path for Nautilus extension to avoid crashes from missing schemas
-    ./hardcode-gsettings.patch
   ];
 
-  postPatch = ''
-    # substitute variable from hardcode-gsettings.patch
-    substituteInPlace deja-dup/nautilus/NautilusExtension.c --subst-var-by DEJA_DUP_GSETTINGS_PATH "${glib.makeSchemaPath (placeholder "out") "${pname}-${version}"}"
-  '';
-
   nativeBuildInputs = [
     meson
     ninja
-    pkgconfig
+    pkg-config
     vala
     gettext
     itstool
-    appstream-glib
-    desktop-file-utils
-    libxml2
     wrapGAppsHook
   ];
 
   buildInputs = [
-    libnotify
     libsoup
     glib
     gtk3
     libsecret
-    pcre
-    libxkbcommon
-    libpthreadstubs
-    libXdmcp
-    epoxy
-    gnome3.nautilus
-    at-spi2-core
-    dbus
-    gnome-online-accounts # GOA not used any more, only for transferring legacy keys
+    libhandy
     libgpgerror
     json-glib
   ];
 
-  # TODO: hard code the path
-  # https://gitlab.gnome.org/World/deja-dup/merge_requests/32
-  propagatedUserEnvPkgs = [ duplicity ];
-
-  # install nautilus plug-in to correct path
-  PKG_CONFIG_LIBNAUTILUS_EXTENSION_EXTENSIONDIR = "${placeholder "out"}/lib/nautilus/extensions-3.0";
+  mesonFlags = [
+    "-Dduplicity_command=${duplicity}/bin/duplicity"
+  ];
 
   meta = with stdenv.lib; {
     description = "A simple backup tool";
diff --git a/pkgs/applications/backup/deja-dup/hardcode-gsettings.patch b/pkgs/applications/backup/deja-dup/hardcode-gsettings.patch
deleted file mode 100644
index f74dbf73543e19..00000000000000
--- a/pkgs/applications/backup/deja-dup/hardcode-gsettings.patch
+++ /dev/null
@@ -1,16 +0,0 @@
---- a/deja-dup/nautilus/NautilusExtension.c
-+++ b/deja-dup/nautilus/NautilusExtension.c
-@@ -313,7 +313,12 @@
-   bindtextdomain(GETTEXT_PACKAGE, LOCALE_DIR);
-   bind_textdomain_codeset(GETTEXT_PACKAGE, "UTF-8");
- 
--  settings = g_settings_new(APPLICATION_ID);
-+  g_autoptr (GSettingsSchemaSource) schema_source = g_settings_schema_source_new_from_directory ("@DEJA_DUP_GSETTINGS_PATH@",
-+    g_settings_schema_source_get_default (), TRUE, NULL);
-+
-+  g_autoptr (GSettingsSchema) schema = g_settings_schema_source_lookup (schema_source, APPLICATION_ID, FALSE);
-+
-+  settings = g_settings_new_full (schema, NULL, NULL);
-   g_signal_connect(settings, "changed::include-list",
-                    update_include_excludes, NULL);
-   g_signal_connect(settings, "changed::exclude-list",