diff --git a/pkgs/applications/editors/emacs/generic.nix b/pkgs/applications/editors/emacs/generic.nix
index 6726790d50fe83..13062ae926139f 100644
--- a/pkgs/applications/editors/emacs/generic.nix
+++ b/pkgs/applications/editors/emacs/generic.nix
@@ -94,8 +94,8 @@ let emacs = stdenv.mkDerivation (lib.optionalAttrs nativeComp {
         ]));
     in ''
       substituteInPlace lisp/emacs-lisp/comp.el --replace \
-        "(defcustom comp-native-driver-options nil" \
-        "(defcustom comp-native-driver-options '(${backendPath})"
+        "(defcustom native-comp-driver-options nil" \
+        "(defcustom native-comp-driver-options '(${backendPath})"
     ''))
     ""
   ];
@@ -175,7 +175,7 @@ let emacs = stdenv.mkDerivation (lib.optionalAttrs nativeComp {
           (comp-trampoline-compile (intern (pop argv))))"
     mkdir -p $out/share/emacs/native-lisp
     $out/bin/emacs --batch \
-      --eval "(add-to-list 'comp-eln-load-path \"$out/share/emacs/native-lisp\")" \
+      --eval "(add-to-list 'native-comp-eln-load-path \"$out/share/emacs/native-lisp\")" \
       -f batch-native-compile $out/share/emacs/site-lisp/site-start.el
   '';
 
diff --git a/pkgs/applications/editors/emacs/site-start.el b/pkgs/applications/editors/emacs/site-start.el
index 01a6422d731fab..3f9ec25d99f0fa 100644
--- a/pkgs/applications/editors/emacs/site-start.el
+++ b/pkgs/applications/editors/emacs/site-start.el
@@ -47,11 +47,11 @@ least specific (the system profile)"
 ;;; Set up native-comp load path.
 (when (featurep 'comp)
   ;; Append native-comp subdirectories from `NIX_PROFILES'.
-  (setq comp-eln-load-path
+  (setq native-comp-eln-load-path
         (append (mapcar (lambda (profile-dir)
                           (concat profile-dir "/share/emacs/native-lisp/"))
                         (nix--profile-paths))
-                comp-eln-load-path)))
+                native-comp-eln-load-path)))
 
 ;;; Make `woman' find the man pages
 (defvar woman-manpath)
diff --git a/pkgs/build-support/emacs/wrapper.nix b/pkgs/build-support/emacs/wrapper.nix
index fcbf5bcabe6d06..571d0eb687ce57 100644
--- a/pkgs/build-support/emacs/wrapper.nix
+++ b/pkgs/build-support/emacs/wrapper.nix
@@ -159,7 +159,7 @@ runCommand
         (add-to-list 'load-path "$out/share/emacs/site-lisp")
         (add-to-list 'exec-path "$out/bin")
         ${optionalString nativeComp ''
-          (add-to-list 'comp-eln-load-path "$out/share/emacs/native-lisp/")
+          (add-to-list 'native-comp-eln-load-path "$out/share/emacs/native-lisp/")
         ''}
         EOF
         # Link subdirs.el from the emacs distribution
@@ -170,7 +170,7 @@ runCommand
 
         ${optionalString nativeComp ''
           $emacs/bin/emacs --batch \
-            --eval "(add-to-list 'comp-eln-load-path \"$out/share/emacs/native-lisp/\")" \
+            --eval "(add-to-list 'native-comp-eln-load-path \"$out/share/emacs/native-lisp/\")" \
             -f batch-native-compile "$siteStart" "$subdirs"
         ''}
       '';