diff --git a/pkgs/development/interpreters/python/hooks/default.nix b/pkgs/development/interpreters/python/hooks/default.nix
index 001e477b9185b2..d75895b819fd7d 100644
--- a/pkgs/development/interpreters/python/hooks/default.nix
+++ b/pkgs/development/interpreters/python/hooks/default.nix
@@ -71,6 +71,15 @@ in {
       };
     } ./pip-install-hook.sh) {};
 
+  pypaBuildHook = callPackage ({ makePythonHook, build, wheel }:
+    makePythonHook {
+      name = "pypa-build-hook.sh";
+      propagatedBuildInputs = [ build wheel ];
+      substitutions = {
+        inherit pythonInterpreter;
+      };
+    } ./pypa-build-hook.sh) {};
+
   pytestCheckHook = callPackage ({ makePythonHook, pytest }:
     makePythonHook {
       name = "pytest-check-hook";
diff --git a/pkgs/development/interpreters/python/hooks/pypa-build-hook.sh b/pkgs/development/interpreters/python/hooks/pypa-build-hook.sh
new file mode 100644
index 00000000000000..add5866ca37485
--- /dev/null
+++ b/pkgs/development/interpreters/python/hooks/pypa-build-hook.sh
@@ -0,0 +1,19 @@
+# Setup hook to use for pypa/build projects
+echo "Sourcing pypa-build-hook"
+
+pypaBuildPhase() {
+    echo "Executing pypaBuildPhase"
+    runHook preBuild
+
+    echo "Creating a wheel..."
+    @pythonInterpreter@ -m build --no-isolation --outdir dist/ $pypaBuildFlags
+    echo "Finished creating a wheel..."
+
+    runHook postBuild
+    echo "Finished executing pypaBuildPhase"
+}
+
+if [ -z "${dontUsePypaBuild-}" ] && [ -z "${buildPhase-}" ]; then
+    echo "Using pypaBuildPhase"
+    buildPhase=pypaBuildPhase
+fi
diff --git a/pkgs/development/interpreters/python/mk-python-derivation.nix b/pkgs/development/interpreters/python/mk-python-derivation.nix
index 17b5667e8ee9c8..c601729a823796 100644
--- a/pkgs/development/interpreters/python/mk-python-derivation.nix
+++ b/pkgs/development/interpreters/python/mk-python-derivation.nix
@@ -14,6 +14,7 @@
 , flitBuildHook
 , pipBuildHook
 , pipInstallHook
+, pypaBuildHook
 , pythonCatchConflictsHook
 , pythonImportsCheckHook
 , pythonNamespacesHook
diff --git a/pkgs/development/python-modules/scipy/default.nix b/pkgs/development/python-modules/scipy/default.nix
index 1090e724a7fd3f..4df6816428681c 100644
--- a/pkgs/development/python-modules/scipy/default.nix
+++ b/pkgs/development/python-modules/scipy/default.nix
@@ -1,9 +1,12 @@
 { lib
 , stdenv
 , fetchPypi
+, pypaBuildHook
 , python
 , pythonOlder
 , buildPythonPackage
+, blas
+, lapack
 , cython
 , gfortran
 , meson-python
@@ -19,6 +22,8 @@
 , libxcrypt
 }:
 
+assert blas.provider == numpy.blas;
+
 buildPythonPackage rec {
   pname = "scipy";
   version = "1.10.1";
@@ -36,10 +41,33 @@ buildPythonPackage rec {
     ./disable-datasets-tests.patch
   ];
 
-  nativeBuildInputs = [ cython gfortran meson-python pythran pkg-config wheel ];
+  # The pybind11 issue seems to have already been address by 2.10.3
+  # https://github.com/pybind/pybind11/issues/4420
+  #
+  # We should update pythran
+  #
+  # Numpy is pinned at patch versions, probably as a way to choose from a set
+  # of wheels published in pypi?
+  postPatch = ''
+    substituteInPlace pyproject.toml \
+      --replace "pybind11==2.10.1" "pybind11>=2.10.3" \
+      --replace '"pythran>=0.12.0,<0.13.0",' "" \
+      --replace "numpy==" "numpy>="
+  '';
+
+  nativeBuildInputs = [
+    pypaBuildHook
+    cython
+    gfortran
+    meson-python
+    pythran
+    pkg-config
+    wheel
+  ];
 
   buildInputs = [
-    numpy.blas
+    blas
+    lapack
     pybind11
     pooch
   ] ++ lib.optionals (pythonOlder "3.9") [
@@ -67,6 +95,15 @@ buildPythonPackage rec {
   #
   hardeningDisable = lib.optionals (stdenv.isAarch64 && stdenv.isDarwin) [ "stackprotector" ];
 
+  dontUsePipBuild = true;
+  pypaBuildFlags = [
+    # Skip sdist
+    "--wheel"
+
+    "-Csetup-args=-Dblas=cblas"
+    "-Csetup-args=-Dlapack=lapacke"
+  ];
+
   checkPhase = ''
     runHook preCheck
     pushd "$out"
@@ -82,8 +119,6 @@ buildPythonPackage rec {
     blas = numpy.blas;
   };
 
-  setupPyBuildFlags = [ "--fcompiler='gnu95'" ];
-
   SCIPY_USE_G77_ABI_WRAPPER = 1;
 
   meta = with lib; {