An ontology of histopathological morphologies
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HPATH: Histopathology Ontology

An ontology of histopathological morphologies used by pathologists to classify/categorise animal lesions observed histologically during regulatory toxicology studies. The ontology was developed using real data from over 6000 regulatory toxicology studies donated by 13 companies spanning nine species.

The original structure of the histopathology ontology was designed ab initio when the INHAND manuscripts were not available. However, the ontology has been repetitively reviewed and updated to align with the subsequently published INHAND manuscripts. During this process cross references to INHAND lesion identifiers were added to the ontology. Note: some parts of ontology are pending a review as the corresponding INHAND manuscripts have not yet been published.

Key Features

  • Created, reviewed and curated by pathologists from multiple organisations.
  • Aligned and cross referenced to INHAND terms.


Histopathology Ontology is delivered in OBO format


Histopathology Ontology was initially developed in frame of the eTOX consortium. It has received support from the Innovative Medicines Initiative Joint Undertaking under grant agreement n°115002, resources of which are composed of financial contribution from the European Union's Seventh Framework Programme (FP7/2007-2013) and EFPIA companies' in kind contribution. We would like to formally acknowledge the contribution to the eTOX project of all scientists and other staff involved.



Copyright 2017 Novartis Institutes for Biomedical Research

Licensed under the Apache License, Version 2.0 (the "License"); you may not use this file except in compliance with the License. You may obtain a copy of the License at

Unless required by applicable law or agreed to in writing, software distributed under the License is distributed on an "AS IS" BASIS, WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. See the License for the specific language governing permissions and limitations under the License.