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OHPI: Ontology of Host-Pathogen Interactions
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README.md

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OHPI: Ontology of Host-Pathogen Interactions

OHPI is a community-driven ontology of host-pathogen interactions (OHPI) and represents the virulence factors (VFs) and how the mutants of VFs in the Victors database become less virulence inside a host organism or host cells. It is developed to represent manually curated HPI knowledge available in the PHIDIAS resource .

Example: The OHPI object property ‘gene mutant attenuated in host cell’ represents a relation between a gene and a host cell where the microbial mutant lacking the gene is attenuated in the host cell compared to the wild type microbe. Such an object property can be used to represent a virulence factor and its interaction in a host cell, e.g., an oxidative stress response gene ahpC of M. tuberculosis strain H37Rv and mouse macrophage cell line J774 cell line where the ahpC mutant of strain Mycobactrium tuberculosis H37Rv is attenuated in J774 cells.

Relevant links

Reference

Sayers S, Li L, Ong E, Deng S, Fu G, Lin Y, Yang B, Zhang S, Fa Z, Zhao B, Xiang Z, Li Y, Zhao Z, Olszewski MA, Chen L, He Y. Victors: a web-based knowledge base of virulence factors in human and animal pathogens. Nucleic Acid Research. 2019 Jan 8;47(D1):D693-D700. doi: 10.1093/nar/gky999. PMID: 30365026. PMCID: PMC6324020.

More detail about OHPI can be found in the supplemental data from the paper: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324020/bin/gky999_supplemental_files.pdf

More information can be found at http://obofoundry.org/ontology/ohpi

Download

Stable release versions

The latest version of the ontology can always be found at:

http://purl.obolibrary.org/obo/ohpi.owl

(note this will not show up until the request has been approved by obofoundry.org)

Editors' version

Editors of this ontology should use the edit version, src/ontology/ohpi-edit.owl

Contact

Please use this GitHub repository's Issue tracker to request new terms/classes or report errors or specific concerns related to the ontology.

Acknowledgements

This ontology repository was created using the ontology starter kit

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