Unicorn: Enhancing Single-Cell Hi-C Data with Blind Super-Resolution for 3D Genome Structure Reconstruction
Unicorn integrates two powerful subsystems: ScUnicorn for super-resolution enhancement of single-cell Hi-C (scHi-C) data and 3DUnicorn for 3D genome structure reconstruction. This system enables high-resolution chromatin modeling and structural inference from sparse and noisy Hi-C data.
This work will be presented at the ISMB/ECCB 2025 conference (July 20-24, 2025) in an oral talk in Liverpool, UK.
OluwadareLab, University of Colorado, Colorado Springs
Please see the wiki for an extensive documentation.
Mohan Kumar B Chandrashekar, Rohit Menon, Samuel Olowofila, Oluwatosin Oluwadare, Unicorn: enhancing single-cell Hi-C data with blind super-resolution for 3D genome structure reconstruction, Bioinformatics, Volume 41, Issue Supplement_1, July 2025, Pages i475–i483, https://doi.org/10.1093/bioinformatics/btaf177
- M. B. Chandrashekar
- R. Menon
- S. Olowofila
- O. Oluwadare
This project is licensed under the MIT License. See the LICENSE file for details.