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README.md

README.md

ACoP 10 mAb PBPK/PD Workshop

PK-Sim® & MoBi® (OSP Suite) workshop on PBPK/PD of ADCs for Tumor Treatment

esqLABS is running a one-day hands-on PK-Sim® & MoBi® workshop on PBPK/PD (PB-QSP) of antibody-drug conjugates (ADCs) for the treatment of tumor growth on Saturday 19th of October at the Rosen Shingle Creek Hotel in Orlando, FL, US as a satellite meeting to ACoP 10 2019. The workshop covers concepts and application of combining PK-Sim, MoBi and R to build your very own digital platforms for the prediction of clinical trial outcomes by leveraging physiological and mechanistic knowledge to translate early in-vitro and preclinical outcomes to the clinic. During hands-on exercises you will learn how to:

  • Build a antibody/protein PBPK model in PK-Sim and compare to observed data
  • Extend the physiology of your PBPK model in MoBi
  • Integrate mechanism-based pharmacodynamics in MoBi
  • Conduct parameter identifications in PK-Sim and MoBi
  • Simulate and analyze your PBPK-QSP model in R

This workshop will be held by consultants & scientists from esqlabs GmbH with extensive experience in the use of PK-Sim® & MoBi® in all application areas.

While the workshop does not require any prior experience with PK-Sim® & MoBi®, many topics will be of interest even for advanced users.

REGISTRATION

To register for the workshop, please do so via your Registration for ACoP 10 on www.go-acop.org.

The workshop is currently restricted to 40 participants.

Registration includes coffee- and lunch breaks.

AGENDA

As a use-case for above learnings, we will develop a PB-QSP model for naked antibody pre-treatment (nAb) for antibody-drug conjugates (ADC) treatment of tumor growth, in detail:

Time (Saturday October 19) Topic
9:00 Welcome and getting everyone started
9:15 Lecture: Introduction to PK-Sim® & MoBi®
9:30 Hands-On: Building an ADC PBPK model
10:00 Coffee Break
10:15 Hands-On: Introduction to mechanistic modeling with MoBi: Target-Mediated Drug Disposition
11:15 Hands-On: Tumor growth modeling
12:00 Lunch Break
13:00 Lecture: Parameter Identification using PK-Sim® and Mobi®
13:30 Hands-On: Parameter Identification
14:00 Coffee Break
14:15 Hands-On: nAb / ADC tumor treatment (PD-Effect)
15:45 Hands-On / Demo: Running simulations with the OSP Suite R-Toolbox in R
16:30 Wrap-up and Q & A
17:00 END

PREPARATION

BRING YOUR OWN LAPTOPS! We will be doing hands-on work!

  • To download the software (WINDOWS ONLY!), please click here
  • Download & install the R distribution (Ver 3.5+; 64 Bit) from here
  • Download & install FREE RStudio Desktop (a GUI for R with additional functionalities for e.g. debugging and code visualization) from here
  • For starters, please check out the tutorial site (videos & hands-on) here

NOTES

  • Please add this site to your watchlist (very top of page) to be informed of any changes.

Visit our News & Events Section for info on additional workshops in the future and news on our future developments in physiologically-based quantitative-systems-pharmacology.



Best Regards,

Stephan Schaller
(Managing Director, esqLABS GmbH)

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