Discussions · Open-Systems-Pharmacology/Forum · GitHub

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Announcement Published: Predictive Performance of Physiology-Based Pharmacokinetic Dose Estimates for Pediatric Trials

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Announcement Published: A generic framework for the physiologically-based pharmacokinetic platform qualification of PK-Sim and its application to predicting cytochrome P450 3A4-mediated drug-drug interactions

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Community guidelines

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Dosage and metabolism

desaimrunal asked Oct 26, 2021 in Questions & Problems · Unanswered

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ibalshammari asked Oct 22, 2021 in Questions & Problems · Answered

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Weight-based dosing with a different body size metric (lean body weight, FFM, BSA, etc)

jgg1822 asked Oct 26, 2021 in Questions & Problems · Unanswered

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Meaning of plasma protein scaling factor in the context of macromolecules

RobinM92 asked Oct 4, 2021 in Questions & Problems · Unanswered

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Variability (confidence interval) in optimized parameter value

hsiebinga asked Apr 23, 2021 in Questions & Problems · Answered

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The problem that the half-life does not decrease uniformly only by adjusting Vmax

gapa84 asked Oct 19, 2021 in Questions & Problems · Unanswered

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Rosuvastatin PBPK model

NinaHanke started Oct 20, 2021 in Announcement

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Unable to load itraconazole model v 1.3. using the beta version

AyaSaleh90 asked Oct 20, 2021 in Questions & Problems · Answered

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Intercompartment Concentrations

pburkat asked Oct 20, 2021 in Questions & Problems · Unanswered

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How can we see the time course of CYP3A?

Carrie-nothing asked Oct 18, 2021 in Questions & Problems · Answered

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Tissue Compartment

pburkat asked Oct 16, 2021 in Questions & Problems · Unanswered

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Creating individuals with genetic variation

harrythmia asked Oct 13, 2021 in Questions & Problems · Answered

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Question about the calculations of the fraction X, Y, Z for predicting the tissue plasma partition coefficient by Rodgers & Rowland method

jessechao830330 asked Oct 13, 2021 in Questions & Problems · Answered

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Question about the definitions of several parameters (K_water_cell, K_water_int, K_rbc, K_int_pls, permeability and SA_pls_int)

jessechao830330 asked Nov 25, 2020 in Questions & Problems · Answered

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Assessing physiological factors.

ranamjz asked Sep 23, 2021 in Questions & Problems · Unanswered

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Extrapolation of Papp to specific intestinal permeability - how to activate the customized calibration method in PK-Sim?

irina-antonescu asked Jan 14, 2021 in Questions & Problems · Answered

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concentration-dependent effect model

MaLuisaEti asked Oct 1, 2021 in Models · Unanswered

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Adjusting solubility for morning vs evening doses over course of multiple dose regimen

choitingy asked Oct 4, 2021 in Questions & Problems · Unanswered

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Opening JSON files with Version 9.1 Update 1

choitingy asked Oct 7, 2021 in Questions & Problems · Answered

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accessing a process rate parameter

wilbertdew asked Oct 7, 2021 in Questions & Problems · Answered

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How can I find the course to learn about the PK-sim software

Zhaowenyu-gaga asked Nov 2, 2020 in Questions & Problems · Answered

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Intraperitoneal administration (IP)

iwaine asked Sep 27, 2021 in Questions & Problems · Unanswered

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Scaling Hepatocyte Clearance (Under-prediction & Offset Method)

paconius asked Sep 26, 2021 in Questions & Problems · Unanswered

#️⃣

gfghy asked Sep 20, 2021 in How-Tos · Answered

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Question to OSP Suite V10

MSmodeler asked Sep 23, 2021 in Questions & Problems · Answered