Open-Systems-Pharmacology / Forum Public

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Announcement Published: Predictive Performance of Physiology-Based Pharmacokinetic Dose Estimates for Pediatric Trials

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Announcement Published: A generic framework for the physiologically-based pharmacokinetic platform qualification of PK-Sim and its application to predicting cytochrome P450 3A4-mediated drug-drug interactions

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Announcement Beta-Release of PK-Sim 10 and MoBi 10

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Community guidelines

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gfghy asked Sep 20, 2021 in How-Tos · Unanswered

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R ospsuite.reportingengine Qualification Framework

kcollins010 asked Sep 14, 2021 in Questions & Problems · Answered

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Can't select formulation

harrythmia asked Sep 14, 2021 in Questions & Problems · Unanswered

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Absorption Incomplete

harrythmia asked Sep 8, 2021 in Questions & Problems · Answered

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Population simulation for an unknown population.

ranamjz asked Sep 12, 2021 in Questions & Problems · Unanswered

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rClr package cannot be loaded in R4.1.0

yangpluszhu asked Sep 3, 2021 in Questions & Problems · Unanswered

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Beta-Release of PK-Sim 10 and MoBi 10

Yuri05 started Aug 2, 2021 in Announcement

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Expresssion level of metabolizing enzymes in normal vs obese patients

Sanjana2697 asked Aug 4, 2021 in Questions & Problems · Unanswered

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about expanding spatial structure

Achineseman asked Aug 30, 2021 in Questions & Problems · Answered

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pburkat asked Aug 27, 2021 in Questions & Problems · Unanswered

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How to set up for subcutaneous administrations?

Achineseman asked Aug 22, 2021 in Questions & Problems · Answered

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PKSIM Beginner, How to add first order Absorption Rate Constant?

jasonargeseanu asked Aug 20, 2021 in Questions & Problems · Unanswered

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Equation missing in documentation

prvmalik asked Aug 18, 2021 in Questions & Problems · Unanswered

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Upload of Physiology parameter for a Cat and Cattle model

KirstenBoerngen asked Aug 18, 2021 in Models · Unanswered

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Converting permeability and ER in presence/absence of BCRP inhibitor into Enzyme Parameters

cbdoc asked Aug 13, 2021 in Questions & Problems · Unanswered

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Partition coefficient (water/container) cannot be found

tztz117 asked Jul 15, 2021 in Questions & Problems · Unanswered

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MoBi- Adding compartment to the model and connecting it to the molecule

Sanjana2697 asked Jul 12, 2021 in Questions & Problems · Unanswered

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How to Apply GFR Formula?

Wenjing1018 asked Nov 24, 2020 in Questions & Problems · Answered

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I am a novice,I try to repeat the model in a document, which is made with PKSIM, but there are some parameters I can't find, and some units I can't convert. What should I do? help me.

Achineseman asked Jul 30, 2021 in Questions & Problems · Answered

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What are your approaches for modeling oral absorption with late Tmax?

prvmalik asked Jul 24, 2021 in Questions & Problems · Unanswered

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How to convert this units?

Achineseman asked Jul 28, 2021 in Questions & Problems · Unanswered

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Fitting ontogeny including variability using PK-Sim Ontogeny Database approach

choitingy asked Jul 29, 2020 in Questions & Problems · Unanswered

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Exchanging observed data files between projects

wilbertdew asked Jul 15, 2021 in Questions & Problems · Answered

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why the uncompetitve inhibiton seem to be wrong, when i change the Ki of uncompetitive inhibition, there is no change of AUC of viticim?

dongji1982 asked Jul 1, 2021 in Questions & Problems · Unanswered

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ELF concentrations of large molecules using MoBi?

RobinM92 asked Jul 1, 2021 in Questions & Problems · Unanswered