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Unable to capture high Cmax after IV bolus dose, all the parameters used were similar between simcyp and PK SIM, but couldnt capture high Cmax in PK SIM?
#250 opened Nov 13, 2018 by REVATHICHAPA
How do I incorporate dissolution data of fasting and fed state in PK SIM model?
#249 opened Nov 13, 2018 by REVATHICHAPA
BCRP expression in red blood cells?
#248 opened Nov 13, 2018 by JGWojtyniak
Enterohepatic recycling of parent drug- conjugated metabolite
#247 opened Nov 13, 2018 by mmalsmadi
Open Systems Pharmacology Suite Documentation is now live!! announcement enhancement
#246 opened Nov 12, 2018 by msevestre
1
hand-on drug drug interaction issue
#244 opened Oct 30, 2018 by wuxuemei300
6
Published: A Quantitative Systems Pharmacology Kidney Model of Diabetes Associated Renal Hyperfiltration and the Effects of SGLT Inhibitors announcement osp-model
#243 opened Oct 26, 2018 by PavelBal
Buccal administration question
#240 opened Oct 19, 2018 by nmens
9
expression for enzyme/transporter protein maturation in absence of ontogeny
#237 opened Oct 17, 2018 by samitganguly
Transporter Reference Concentration fmol/ug protein to umol/L: Scaling factor?
#235 opened Oct 12, 2018 by krinaj
3
Scaling partition coefficients in Population simulation answer question
#234 opened Oct 8, 2018 by karthikl6
5
Synthesis of endogenous protein in arterial/vernous compartment?? answer question
#231 opened Oct 2, 2018 by DanielMoj
8
Protein binding displacement help wanted question
#230 opened Oct 2, 2018 by Mutaz94
Metabolite concentration time data help wanted question
#229 opened Sep 29, 2018 by samitganguly
2
transporter kinetic parameters help wanted question
#227 opened Sep 19, 2018 by aargikar
1
Community OSP (Database) extensions community-feedback
#224 opened Sep 13, 2018 by StephanSchaller
3
Are there parameters for Latin American populations? help wanted question
#223 opened Sep 12, 2018 by Vanderson88
1
Advice on Fitting My Rifampin Model Better? help wanted
#222 opened Sep 10, 2018 by yishuanwu
2
How to deal with CYP Expression in GIT - Non-mucosal tissue?
#221 opened Sep 3, 2018 by tobiasK2001
Question on modelling a control release formulation in PKsim
#219 opened Aug 24, 2018 by amitvtaneja
1
Dissolution Profiles question
#218 opened Aug 21, 2018 by AlejandraSchiavo
expression of CYP2D6 question
#217 opened Aug 16, 2018 by aargikar
1
Help with continuous infusion dose on OSP/PK-Sim answer question
#215 opened Aug 16, 2018 by samitganguly
14
Error message: Error solving ODE at time t=x: Either convergence test failures occurred too many times during one internal time step, or with |h| = hmin (CV_CONV_FAILURE) answer help wanted question
#210 opened Aug 13, 2018 by NinaHanke
3
Published: PBPK models for CYP3A4 and P‐gp DDI prediction: a modeling network of rifampicin, itraconazole, clarithromycin, midazolam, alfentanil and digoxin. announcement
#209 opened Aug 10, 2018 by NinaHanke
ProTip! What’s not been updated in a month: updated:<2018-10-15.