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Enterohepatic recirculation #122

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aargikar opened this Issue Jan 10, 2018 · 4 comments

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aargikar commented Jan 10, 2018

Hi,
I was wondering enterohepatic recirculation could be added in PK-Sim. I have already added Bile clearance but it doesn't seem to cause the recirculation as it happens in vivo. Hence, AUC is severely underpredicted. Please let me know if this could be achieved. Thank you.

@msevestre msevestre added the question label Jan 10, 2018

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msevestre Jan 10, 2018

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Hi @aargikar
Yes this is available in PK-Sim. Please refer to manual, Chapter 18. PK-Sim® - Events for a detailed explanation on how to proceed.

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msevestre commented Jan 10, 2018

Hi @aargikar
Yes this is available in PK-Sim. Please refer to manual, Chapter 18. PK-Sim® - Events for a detailed explanation on how to proceed.

Hope that helps

@msevestre msevestre added the answer label Jan 10, 2018

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aargikar Jan 11, 2018

Hi @msevestre,
I added the event + gall bladder emptying as Yes. I also manipulated the gall bladder ejection fraction and EHC continuous fraction. But none of these parameters improved the simulation. Is there a PK-Sim example file which I could work with /view? Please let me know. Thank you.

aargikar commented Jan 11, 2018

Hi @msevestre,
I added the event + gall bladder emptying as Yes. I also manipulated the gall bladder ejection fraction and EHC continuous fraction. But none of these parameters improved the simulation. Is there a PK-Sim example file which I could work with /view? Please let me know. Thank you.

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msevestre Jan 18, 2018

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@aargikar I would suggest to follow the common best practices for PBPK model development. EHC might not be the problem there

Check the following link. The article describes a step by step approach to building PBPK models with e.g. PK-Sim.

Hope that helps

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msevestre commented Jan 18, 2018

@aargikar I would suggest to follow the common best practices for PBPK model development. EHC might not be the problem there

Check the following link. The article describes a step by step approach to building PBPK models with e.g. PK-Sim.

Hope that helps

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aargikar Jan 25, 2018

Thank you.

aargikar commented Jan 25, 2018

Thank you.

@msevestre msevestre closed this Feb 15, 2018

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